Academic literature on the topic '581.350 9'

Chlorocobalt(III) complexes of the pendant-arm macrocycles 1,4,8,12-tetraazacyclopentadecane-10-carboxylate (2) and 1,5,9,13-tetraazabicyclo[11.2.2]heptadecane-7-carboxylate (4) have been prepared to complement the known complexes of 10-methyl-1,4,8,12-tetraazacyclopentadecan-10-amine (1) and 7-methyl-1,5,9,13-tetraazabicyclo[11.2.2]heptadecan-7-amine (3). The pairs (1),(3) and (2),(4) differ in replacement of pendant amine and methyl groups in the former pair by a pendant carboxylate group and hydrogen in the latter pair. The macromonocyclic ligands (1) and (2) form cis-chlorocobalt(III) complexes whereas the macrobicyclic ligands (3) and (4) (which contain an additional –CH2–CH2– ‘strap’ linking two amines) form trans-chlorocobalt(III) complexes, defined in terms of location of the pendant donor and the chloride donor. Chloride base hydrolysis kinetics varies with ligand {cis-[Co(1)Cl]2+, kOH 6700 dm3 mol-1 s-1 ; cis-[Co(2)Cl] +, kOH 1800 dm3 mol-1 s-1;trans-[Co(3)Cl]2+, kOH 3450 dm3 mol-1 s-1; trans-[Co(4)Cl]+, kOH 2250 dm3 mol-1 s-1 at 25°C}. Variations in rate constant are tied mainly to variations in activation enthalpy. Chloride hydrolyses occur with retention of configuration, but slow following isomerization can lead to products such as trans-[Co(2)(OH2)] (ClO4)2.2H2O, which crystallizes in the monoclinic space group P21/c, a 9·581(2), b 16·214(2), c 14·350(2) Å and β 94·66(1)°. The pendant carboxylate group and two adjacent secondary amines necessarily occupy an octahedral face, with the water molecule bound trans to the pendant carboxylate. The four Co–N distances range from 1·981(2) to 2·22(3) Å, and along with carboxylate Co–O (1·882(3) Å) and water Co-O (1·934(2) Å) distances are similar to usual distances in cobalt(III) complexes.

During the reporting year, 623 pregnant women and women in labor were admitted to the clinic; of these, 598 were resolved in the clinic, and 25 dropped out before giving birth; from May 1 to September 19, there was no delivery of women in labor. There were 138 primiparas (23.1%), voniparas 142 (23.7%), and many 318 (53.2%); primiparas over 30 years old met 20, including one 47 years old. There were 584 single genera and 14 twins. Urgent 506, premature 73, miscarriages 19. Presentation (except for 11 early miscarriages): headache 571 (95.0%), shoulder 3 (0.5%); of the head: occipital 558, parietal 2, ear 1, facial 5, not recognized (street delivery, etc.) 5. A narrow pelvis was observed in 54 cases (9%).

Abstract Abstract 581 Primary refractory or relapsed B-lineage acute lymphoblastic leukemia can be successfully treated by allogeneic stem cell transplantation (SCT). However, relapse remains still a major risk and will be significantly influenced by residual disease prior to or after SCT. In addition to standard chemotherapy, immunotherapeutic approaches are assumed to be able to reduce or clear persistent minimal disease. Here we investigated an Fc-optimized chimerized CD19 antibody on a compassionate use basis in pediatric patients at very high risk prior to and after allogeneic, HLA matched (n=2) or mismatched (n=9) first or subsequent SCT. Through its improved capability to recruit FcγRIIIA bearing effector cells, this mAb mediates enhanced ADCC by NK cells but no complement lysis. 11 patients with B-lineage ALL (CR2 with MRD>10−4, n=3; ≥CR3, n=4; active disease, n=4; 8/11 had previous SCTs) received a mean number of 10 (range 1–30) infusions with an anti-CD19 mAb (4G7SDIE) over 6 hours weekly or every second week posttransplant. In 7 patients, additional infusions were given prior to transplant. Dosages ranged from 5 to 50 mg/m2. The infusions were well tolerated without any severe side effects; only fever or headache was observed in a few patients (n=4). Minimal residual disease (MRD) or overt relapse (>50% blasts) was detectable in bone marrow aspirates prior to therapeutic mAb administration in 5/11 and 2/11 patients, respectively. Prophylactic CD19mAb infusions were given posttransplant without measurable MRD levels in 4/11 patients and in another 2 patients (who did not respond to pretransplant CD19mAb because of overt relapse but reached MRD negativity after SCT) due to an extremely high relapse risk. In 4 out of 5 patients with detectable MRD, leukemic load was reduced for at least 1 log or eradicated by the mAb. 2 out of those patients relapsed, 2 other patients are in molecular remission since 270 and 350 days. Both patients with overt relapse did not respond. 2/6 patients with prophylactic mAb infusions relapsed after 121 and 186 days, 4 other patients remain in molecular remission since 52–180 days. Taken together, a response could be documented in 4/7 patients; a total of 6/11 patients are in molecular remission (median follow up 157 days). Concomitant in vitro investigations showed that NK cells of the patients exerted insufficient lysis of primary B-lineage ALL blasts (mean specific lysis: 4,00%). However, lysis could be significantly increased by adding autologous patient serum taken after antibody treatment (mean specific lysis: 20,33 %, p = 0.0001, student's t-test) or by adding 1 μg/ml 4G7SDIE (mean specific lysis: 34.84 %, p < 0.0001). Activity of patient NK cells was similar to NK cells of healthy donors. ADCC relevant serum titers of biologically active CD19mAb were detectable up to 7 days after antibody infusion. In conclusion, promising antileukemic effects have been observed in vitro and in vivo in this pilot study and a further clinical trial has to address the question whether this approach will be able to reduce relapse rates. Disclosures: No relevant conflicts of interest to declare.

Abstract. The earthquake which struck the city of Lorca, Spain, on 11 May 2011 killed 9 people, injured over 300 and caused considerable damage, including one collapsed building. Streets near buildings were the main danger areas for people. This article proposes an dynamic ad hoc spatio-temporal method for studying individual evacuation after an earthquake. Its application to the Lorca case shows the spatial and temporal variability of individual exposure levels in the street during the hours following the shock. As yet little studied, human exposure deserves more attention, particularly in zones of moderate seismicity like the Euro-Mediterranean area. The results of this study could be helpful for enhancing the evacuation planning after an earthquake, stressing the specific dangers in the street.

Abstract. We use principal component regression and partial least squares regression to separately reconstruct a composite series of temperature variations in China, and associated uncertainties, at a decadal resolution over the past 2000 yr. The reconstruction is developed using proxy temperature data with relatively high confidence levels from five regions across China, and using a temperature series from observations by the Chinese Meteorological Administration, covering the period from 1871 to 2000. Relative to the 1851–1950 climatology, our two reconstructions show four warm intervals during AD 1–AD 200, AD 551–AD 760, AD 951–AD 1320, and after AD 1921, and four cold intervals during AD 201–AD 350, AD 441–AD 530, AD 781–AD 950, and AD 1321–AD 1920. The temperatures during AD 981–AD 1100 and AD 1201–AD 1270 are comparable to those of the Present Warm Period, but have an uncertainty of ±0.28 °C to ±0.42 °C at the 95% confidence interval. Temperature variations over China are typically in phase with those of the Northern Hemisphere (NH) after 1000, a period which covers the Medieval Climate Anomaly, the Little Ice Age, and the Present Warm Period. In contrast, a warm period in China during AD 541–AD 740 is not obviously seen in the NH.

Stuart Ball, The Conservative Party since 1945 (Manchester: Manchester University Press, 1998), 205 pp., £40.00, ISBN 0-7190-4012-4.John Charmley, A History of Conservative Politics, 1900–1996 (London: Macmillan, 1996), 283 pp., £16.99, ISBN 0-333-56293-3.Alan Clark, The Tories: Conservatives and the Nation State 1922–1997 (London: Weidenfeld & Nicolson, 1998), 493 pp., £20.00, ISBN 0-297-81849-X.N. J. Crowson, Facing Fascism: The Conservative Party and the European Dictators 1935–1940 (London: Routledge, 1997), 270 pp., £20.00, ISBN 0-415-15315-8.Brendan Evans and Andrew Taylor, From Salisbury to Major: Continuity and Change in Conservative Politics (Manchester: Manchester University Press, 1996), 288 pp., £14.99, ISBN 0-7190-4291-7.Steven Ludlam and Martin J. Smith, Contemporary British Conservatism (London: Macmillan, 1996), 322 pp., £14.99, ISBN 0-333-62949-3.Philip Norton (ed.), The Conservative Party (London: Prentice Hall, 1996), 264 pp., £15.95, ISBN 0-13-374653-4.John Ramsden, An Appetite for Power: A History of the Conservative Party since 1830 (London: HarperCollins, 1998), 562 pp., £24.99, ISBN 0-002-55686-3.John Ramsden, The Age of Churchill and Eden 1940–1957 (London: Longman, 1995), 350 pp., £57.50, ISBN 0-582-50463–5.John Ramsden, The Winds of Change: Macmillan to Heath 1957–1975 (London: Longman, 1996), 485 pp., £70.00, ISBN 0-582-27570-9.Anthony Seldon (ed.), How Tory Governments Fall (London: Fontana, 1996), 510 pp., £7.99, ISBN 0-00-686366-3.Anthony Seldon and Stuart Ball (eds.), Conservative Century: The Conservative Party since 1900 (Oxford: Oxford University Press, 1994), 842 pp., £20.00, ISBN 0-19-820238-5.Robert Self, The Austen Chamberlain Diary Letters: The Correspondence of Sir Austen Chamberlain with his sisters Hilda and Ida, 1916–1937 (Cambridge: Cambridge University Press for the Royal Historical Society, 1995), 548 pp., £40.00., ISBN 0-521-55157-9.

Dendrochronological studies are being carried out on two conifer species in the Stanley River area of western Tasmania. The chronology for Huon pine (Lagarostrobos franklinii), with living trees up to 1400 yr old, extends back to 571 bc. Living celery-top pine (Phyllocladus aspleniifolius) trees are up to 500 yr old. Apart from living or recently felled trees, sections have been taken from 350 subfossil logs preserved in floodplain sediments. They range in age from >38 ka to modern, with good coverage for the periods 9–3.5 ka and from 2.5 ka to the present. We report here on 14C measurements of decadal samples from three early Holocene logs, between 10 and 9 ka bp, providing short (ca. 300-yr) records of atmospheric 14C variations when plotted against ring numbers. The southern hemisphere data from Tasmania can be compared and wiggle-matched with published 14C calibration curves from German oak and pine. One set of measurements covers the period, ca. 9280–8990 cal bp, overlapping the link between the Hohenheim “Main 9” and middle Holocene master oak chronologies. The other sets of measurements from Tasmania coincide; they span the period, ca. 9840–9480 cal bp, overlapping the end of the German Preboreal pine and the beginning of the oak chronologies. Our measurements confirm that this part of the calibration curve is a gently sloping 14C-age plateau (ca. 8900–8700 bp, between 10,000 and 9500 cal bp), and suggest interhemispheric 14C differences close to zero.