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1

McKee, B. T. A., A. T. Stewart, and J. Vesel. "Detection efficiency of thick microchannel plates to 511 keV gamma rays." Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 234, no. 1 (1985): 191–97. http://dx.doi.org/10.1016/0168-9002(85)90828-9.

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2

Simonova, G. I., S. V. Mustafina, Yu P. Nikitin, and L. V. Shcherbakova. "WAIST CIRCUMFERENCE AS INDICATOR COMPONENTS OF METABOLIC SYNDROME IN THE SIBERIAN POPULATION." Bulletin of Siberian Medicine 13, no. 2 (2014): 88–94. http://dx.doi.org/10.20538/1682-0363-2014-2-88-94.

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Object of research: to determine the cut-off point of waist circumference (WC) identify the components of metabolic syndrome (MS) in a large industrial center of Western Siberia.In the period from 2003 to 2005 in the screening population surveyed 9362 people, including 4268 men (45.6%) and 5094 women (54.4%).The response rate was 61%. The study protocol included a sociodemographic data, measurement of blood pressure (BP), anthropometry (height, weight, WC), the definition of biochemical parameters. Statistical analysis was performed using the package SPSS. To determine the cut-off points of th
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3

Watanabe, Ko, Takuto Hikichi, Jun Nakamura, et al. "Endoscopic submucosal dissection for early gastric cancer in very elderly patients age 85 or older." Endoscopy International Open 05, no. 01 (2017): E17—E24. http://dx.doi.org/10.1055/s-0042-122960.

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Abstract Background and study aims The safety and efficacy of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) in very elderly patients remains unclear. The aim of this study was to evaluate the safety and efficacy of ESD for EGC in patients age 85 years and older. Patients and methods Patients who underwent ESD for EGC between September 2003 and April 2015 were divided into 3 groups: the very elderly (≥ 85 years; 43 patients), the elderly (65 – 84 years; 511 patients), and the non-elderly ( ≤ 64 years; 161 patients). Adverse events (AEs) were used as the primary endpoint
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4

Pinato, David James, Ahmed Omar Kaseb, Yinghong Wang, et al. "Impact of baseline and concomitant corticosteroid therapy on the outcomes of hepatocellular carcinoma treated with immune checkpoint inhibitor therapy." Journal of Clinical Oncology 38, no. 4_suppl (2020): 531. http://dx.doi.org/10.1200/jco.2020.38.4_suppl.531.

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531 Background: The impact of corticosteroid treatment (CT) on the efficacy of immune checkpoint inhibitors (ICI) in hepatocellular carcinoma (HCC) is undefined. We evaluated whether CT administered at baseline (bCT) or concurrently to ICI (cCT) influences clinical outcomes of HCC patients treated with ICI. Methods: This retrospective, multi-center observational study was conducted across 9 tertiary academic referral centers collected 341 HCC patients who received ICI across 3 continents between January 1, 2016 and April 1, 2019. Outcome measures included overall (OS) and progression-free surv
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5

Mansell, A. L., R. R. Moalli, C. L. Calista, and A. C. Pipkin. "Elastic moduli of lungs during postnatal development in the piglet." Journal of Applied Physiology 67, no. 4 (1989): 1422–27. http://dx.doi.org/10.1152/jappl.1989.67.4.1422.

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Several manifestations of lung disease during infancy suggest that mechanical interdependence can be relatively high in newborn lungs. To test this possibility, we measured elastic moduli and pleural membrane tension in lungs excised from piglets ranging in age from less than 12 h to 85 days. Near maximum inflation, newborn lungs (less than 12 h, n = 6) had no detectable pleural membrane tension, although 3- to 5-day-old lungs (n = 6) had tension greater than 5,000 dyn/cm. In contrast, parenchymal recoil was greater in the newborn lungs [19.3 +/- 3.0 (SD) vs. 14.3 +/- 2.4 cmH2O at 90% of maxim
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Morales-Múnera, Olga Lucía, Carolina Andrea Rosero-Ascuntar, Martha Cuellar-Santaella Cuellar-Santaella, Edison Alberto Aristizábal-Serna, and Aracelly Villegas-Castaño. "Utilidad de los criterios de Murray para el procesamiento de esputo en pacientes con fibrosis quística. Laboratorio de Infectados de la Universidad de Antioquia (Medellín/Colombia)." Infectio 24, no. 4 (2020): 229. http://dx.doi.org/10.22354/in.v24i4.881.

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Introducción: la fibrosis quística (FQ) es una enfermedad autosómica recesiva que aumenta la viscosidad de las secreciones, en especial las del árbol respiratorio; genera inflamación crónica y colonización/infección por microorganismos, conduciendo a deterioro de la función pulmonar y muerte. Nuestro estudio evaluó la calidad del esputo de pacientes con FQ que ingresaron al Laboratorio de Infectados de la UdeA con base a los criterios de Murray. Metodología: estudio descriptivo con información retrospectiva, incluyendo todos los esputos de pacientes con FQ, recolectados entre enero de 2015 a d
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7

Kutluk, M. Tezer, and Akif Yesilipek. "Pediatric cancer registry Turkey: 2009-2016 (TPOG & TPHD)." Journal of Clinical Oncology 35, no. 15_suppl (2017): e22015-e22015. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e22015.

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e22015 Background: Each year 300.000 new cancer cases are expected in children & adolescents aged 0-19 years at global level. Although the long term survival rates have been improved to 85% in high income countries it is lower than this LMICs. Pediatric registries are essential for planning, evaluation, comparison for pediatric cancer care. This study focuses to pediatric cancer registry in Turkey. Methods: Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Association established a WEB based cancer registry in Turkey in 2002. The registry information for 2002-2008 was prese
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8

Ahluwalia, Manmeet, Stephanie Pugh, Benjamin Ellingson, et al. "RBTT-11. NRG ONCOLOGY NRG-BN006: A PHASE II/III RANDOMIZED, OPEN-LABEL STUDY OF TOCA 511 AND TOCA FC WITH STANDARD OF CARE COMPARED TO STANDARD OF CARE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi220—vi221. http://dx.doi.org/10.1093/neuonc/noz175.922.

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Abstract The standard of care (SOC) in newly diagnosed glioblastoma (nGBM) includes resection and chemoradiotherapy. With a median overall survival (OS) of only 16–18 months for well-selected patients in clinical trials, better therapeutic options are needed. Toca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding a codon optimized, heat stabilized cytosine deaminase that converts Toca FC (extended-release 5- fluorocytosine,5-FC) into 5-fluorouracil. Preclinical evidence demonstrates that Toca 511 & 5-FC kill cancer cells and immunosuppressive myeloid cells in the
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9

Yeager, AM, C. Shinn, and DM Pardoll. "Lymphoid reconstitution after transplantation of congenic hematopoietic cells in busulfan-treated mice." Blood 78, no. 12 (1991): 3312–16. http://dx.doi.org/10.1182/blood.v78.12.3312.3312.

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Abstract The effects of pretransplant conditioning with high-dose busulfan, a myeloablative but nonimmunosuppressive alkylating agent, on reconstitution of lymphoid tissues by donor cells after bone marrow transplantation (BMT) has not been extensively examined. We used flow cytometric analyses to study the kinetics and extent of lymphocyte repopulation in C57BL/6 mice (immunophenotype Ly-5.2) given graded doses of busulfan (10 to 100 mg/kg) or total body irradiation (TBI; 900 rad) and hematopoietic cell transplantation (HCT; transplantation of bone marrow and spleen cells) from congenic Ly-5.
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10

Yeager, AM, C. Shinn, and DM Pardoll. "Lymphoid reconstitution after transplantation of congenic hematopoietic cells in busulfan-treated mice." Blood 78, no. 12 (1991): 3312–16. http://dx.doi.org/10.1182/blood.v78.12.3312.bloodjournal78123312.

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The effects of pretransplant conditioning with high-dose busulfan, a myeloablative but nonimmunosuppressive alkylating agent, on reconstitution of lymphoid tissues by donor cells after bone marrow transplantation (BMT) has not been extensively examined. We used flow cytometric analyses to study the kinetics and extent of lymphocyte repopulation in C57BL/6 mice (immunophenotype Ly-5.2) given graded doses of busulfan (10 to 100 mg/kg) or total body irradiation (TBI; 900 rad) and hematopoietic cell transplantation (HCT; transplantation of bone marrow and spleen cells) from congenic Ly-5.1 donors.
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11

Dubenko, Anastasiia V., Mykola V. Nikolenko, Andrii Kostyniuk, and Blaž Likozar. "Sulfuric Acid Leaching of Altered Ilmenite Using Thermal, Mechanical and Chemical Activation." Minerals 10, no. 6 (2020): 538. http://dx.doi.org/10.3390/min10060538.

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The kinetics of the sulfuric acid leaching of altered ilmenite, mechanisms, and process intensification methods were studied. The effect of changing the chemical composition during grinding was determined. The content of ilmenite and pseudorutile decreased from 5.3% to 3.1% and from 90.2% to 63.1%, respectively. Rutile increased from 4.5% to 28.7%, while a pseudobrookite new phase appeared in the amount of 5.1% after 2 h of grinding. It was found that the modification of raw material by sulfuric acid led to the increase of the decomposition rate, and at the same time, decreased when the ore wa
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12

Wakeman, Lisa, Roger Munro, Chris Russell, Ann Benton, Sally Hartnell, and Saad Al-Ismail. "New Reference Ranges in Haematology for Healthy Adults Using the Modern Sysmex XE-2100 Automated Analyser." Blood 106, no. 11 (2005): 3740. http://dx.doi.org/10.1182/blood.v106.11.3740.3740.

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Abstract Establishing clearly defined, accurate reference ranges facilitates good interpretation and effective discrimination between health and disease. These can be used to obviate the need for unnecessary follow-up medical examinations thereby reducing costs. Our data represent findings from one of the most comprehensive studies ever undertaken with the XE-2100 to establish reference ranges (RRs) in healthy adults. Early morning venous samples were collected into Greiner EDTA Vacuettes (Ref: 454286) from 221 healthy laboratory personnel (F= 159;M = 62) aged 20–63 yrs for both gender. Age gr
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13

LIMA, MIRTES F., ISABEL C. BEZERRA, SIMONE G. RIBEIRO, and ANTÔNIO C. DE ÁVILA. "Distribuição de geminivírus nas culturas do tomate e pimentão em doze municípios do Submédio do Vale São Francisco." Fitopatologia Brasileira 26, no. 1 (2001): 81–85. http://dx.doi.org/10.1590/s0100-41582001000100014.

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Em 1996 e 1997, observaram-se sintomas de viroses causadas por geminivírus transmitidos por mosca branca em plantas de tomateiro (Lycopersicon esculentum) e pimentão (Capsicum annuum) no Submédio do Vale São Francisco, situado nos Estados de Pernambuco e Bahia. De outubro de 1996 a dezembro de 1998, foram coletadas 1.368 amostras foliares de tomateiro e 194 de pimentão, exibindo sintomas similares àqueles causados por geminivírus, em 104 e 16 plantios, respectivamente, de 12 municípios dessa região e em dois municípios vizinhos. A incidência de geminiviroses nas áreas amostradas foi estimada e
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14

Ramires, Roseane Del'Arco, and Roberto Alves de Oliveira. "COD, TSS, nutrients and coliforms removals in UASB reactors in two stages treating swine wastewater." Engenharia Agrícola 34, no. 6 (2014): 1256–69. http://dx.doi.org/10.1590/s0100-69162014000600020.

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The performance of two upflow anaerobic sludge blanket (UASB) reactors was evaluated in pilot scale (908 and 188 L), installed in series (R1 and R2), fed with swine wastewater with TSS around 5 and 13 g L-1. The UASB reactors were submitted to HDT of 36 and 18 h with VOL of 5.5 to 34.4 g COD (L d)-1 in the R1 and HDT of 7.5 e 3.7 h with VOL from 5.1 to 45.2 g COD (L d)-1 in the R2. The average removal efficiencies of COD ranged from 55 to 85% in the R1 and from 43 to 57% in the R2, resulting in values from 82 to 93% in the UASB reactors in two stage. Methane concentrations in the biogas were 6
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15

Valent, Francesca, and Annarita Tullio. "Glycaemic control, antidiabetic medications and influenza vaccination coverage among patients with diabetes in Udine, Italy." Family Medicine and Community Health 7, no. 3 (2019): e000198. http://dx.doi.org/10.1136/fmch-2019-000198.

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ObjectiveThe objectives of this study were to estimate influenza vaccination coverage among patients with diabetes mellitus in an Italian 250 000-inhabitant area in the 2017–2018 season and to assess whether glycaemic control and pharmacological treatment were associated with the likelihood of being vaccinated.DesignIn this cross-sectional study, we analysed anonymous health administrative databases, linked with each other at the individual patient level through a stochastic key: diabetes mellitus registry, vaccinations, drug prescriptions and laboratory database.SettingThe study was conducted
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16

Reuland, Colleen P., Jon Collins, Lydia Chiang, et al. "Oregon’s approach to leveraging system-level data to guide a social determinants of health-informed approach to children’s healthcare." BMJ Innovations 7, no. 1 (2020): 18–25. http://dx.doi.org/10.1136/bmjinnov-2020-000452.

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BackgroundChildren’s health and healthcare use are impacted by both medical conditions and social factors, such as their home and community environment. As healthcare systems manage a pediatric population, information about these factors is crucial to providing quality care coordination.MethodsThe authors developed a novel methodology combining medical complexity (using the Pediatric Medical Complexity Algorithm) and social complexity (using available family social factors known to impact a child’s health and healthcare use) to create a new health complexity model at both the population-level
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17

Auge, Josep M., Cristina Rodriguez, Oihana Espanyol, et al. "An evaluation of the SENTiFIT 270 analyser for quantitation of faecal haemoglobin in the investigation of patients with suspected colorectal cancer." Clinical Chemistry and Laboratory Medicine (CCLM) 56, no. 4 (2018): 625–33. http://dx.doi.org/10.1515/cclm-2017-0605.

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Abstract Background: An evaluation of SENTiFIT® 270 (Sentinel Diagnostics, Italy; Sysmex, Spain) analyser for the quantitation of faecal haemoglobin (f-Hb) was performed. Methods: The analytical imprecision, linearity, carry over and f-Hb stability were determined. Evaluation of the diagnostic accuracy was performed on 487 patients. Results: Within-run and between-run imprecision ranged 1.7%–5.1% and 3.8%–6.2%, respectively. Linearity studies revealed a mean recovery of 101.1% (standard deviation, 6.7%) for all dilutions. No carry over was detected below 7650 μg Hb/g faeces. Decay of f-Hb in r
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18

Slagman, Anna, Linton Harriss, Sandra Campbell, Reinhold Muller, and Robyn McDermott. "Folic acid deficiency declined substantially after introduction of the mandatory fortification programme in Queensland, Australia: a secondary health data analysis." Public Health Nutrition 22, no. 18 (2019): 3426–34. http://dx.doi.org/10.1017/s1368980019002258.

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AbstractObjective:To investigate the prevalence of folic acid deficiency in Queensland-wide data of routine laboratory measurements, especially in high-risk sub-populations.Design:Secondary health data analysis.Setting:Analysis of routine folic acid tests conducted by Pathology Queensland (AUSLAB).Participants:Female and male persons aged 0–117 years with routine folic acid testing between 1 January 2004 and 31 December 2015. If repeat tests on the same person were conducted, only the initial test was analysed (n 291 908).Results:Overall the prevalence of folic acid deficiency declined from 7·
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19

Shinmura, Tetsuya, Kazunori Adachi, Yoshiharu Yamaguchi, et al. "Vonoprazan-Based Triple-Therapy Could Improve Efficacy of the Tailored Therapy of Helicobacter pylori Infection." Journal of Gastrointestinal and Liver Diseases 28, no. 4 (2019): 389–95. http://dx.doi.org/10.15403/jgld-222.

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Background and Aims: The prevalence of clarithromycin resistant bacteria is increasing, and the effectiveness of Helicobacter pylori (H. pylori) triple therapy is gradually decreasing in Japan. Vonoprazan, a potassiumcompetitive acid blocker, has been reported for its effectiveness in eradicating H. pylori. We aimed to evaluate the efficacy of tailored vonoprazan-based triple therapy in patients with H. pylori. This study is the first to compare the efficacy of vonoprazan-based tailored triple therapy to that of vonoprazan-based conventional therapy.
 Method: This retrospective cohort stu
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Ahmed, Ashraf H., Richard D. Gordon, Gregory Ward, et al. "Effect of Combined Hormonal Replacement Therapy on the Aldosterone/Renin Ratio in Postmenopausal Women." Journal of Clinical Endocrinology & Metabolism 102, no. 7 (2017): 2329–34. http://dx.doi.org/10.1210/jc.2016-3851.

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Abstract Background: Plasma aldosterone/renin ratio (ARR) is the most popular screening test for primary aldosteronism (PA). Because both estrogen and progesterone (including in oral contraceptive agents) affect aldosterone and renin levels, we studied the effects of combined hormonal replacement therapy (HRT) on ARR; renin was measured as both direct renin concentration (DRC) and plasma renin activity (PRA). Methods: Fifteen normotensive, healthy postmenopausal women underwent measurement (seated, midmorning) of plasma aldosterone, DRC, PRA, electrolytes, and creatinine and urinary aldosteron
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Paik, Paul K., Remi Veillon, Enriqueta Felip, et al. "METex14 ctDNA dynamics & resistance mechanisms detected in liquid biopsy (LBx) from patients (pts) with METex14 skipping NSCLC treated with tepotinib." Journal of Clinical Oncology 39, no. 15_suppl (2021): 9012. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.9012.

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9012 Background: In the VISION study, tepotinib in METex14 skipping NSCLC pts (Cohort A) had robust and durable clinical activity. Serial LBx samples were collected for biomarker analyses, presented herein. Methods: LBx samples taken at baseline (BL), Week 6, 12, & end of treatment (EOT) were analyzed using Guardant360® CDx (73 genes). Investigator (INV)-assessed clinical outcome was evaluated per BL biomarker profiles and by molecular response (MR; defined as > 75% depletion from BL in METex14 variant allele frequency [VAF] ctDNA confirmed in 2 consecutive samples) or molecular progres
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Tsushima, Takahiro, Keita Mori, Kentaro Yamazaki, et al. "Analysis of totally implantable venous access port systems (TIVAPS) related adverse events (AEs) in metastatic colorectal cancer (mCRC) patients treated with and without bevacizumab." Journal of Clinical Oncology 31, no. 15_suppl (2013): e14623-e14623. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e14623.

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e14623 Background: TIVAPS are widely used for cancer chemotherapy. Bevacizumab, a key drug for mCRC, associates with AEs such as thromboembolism, bleeding, and impaired wound healing. Bevacizumab may complicit in increasing incidence of TIVAPS related AEs. To assess the incidence of TIVAPS related AEs in mCRC patients who received chemotherapy with and without bevacizumab. Methods: We retrospectively reviewed the medical records of consecutive patients whose TIVAPS were placed at our institution between Apr. 2004 and Apr. 2009. Major selection criteria were histologically proven colorectal ade
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Valeri, Federica, Alessandra Borchiellini, Piercarla Schinco, and Mario Boccadoro. "Paroxysmal Nocturnal Hemoglobinuria With Budd-Chiari Syndrome Treated With Complement Inhibitor Eculizumab; A Case Report." Blood 122, no. 21 (2013): 4800. http://dx.doi.org/10.1182/blood.v122.21.4800.4800.

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Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired haemolytic anaemia caused by somatic mutation in the phosphatidylinositol glycan-complementation class A gene, resulting in absence of a key complement regulatory protein, CD59. Thrombosis occurs in up to 40% of PNH patients; it usually involves abdominal and cerebral veins and it is the leading cause of death disease related. Methods We describe the response to Eculizumab (Soliris, Alexion) in 28 years old male with PNH diagnosed as a consequence of Budd Chiari Syndrome, acute liver dysfunction, mild haemolytic anaemia
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Pierone, Gerald, Kathy Schulman, Jennifer S. Fusco, et al. "2483. Characteristics and Outcomes Over First 12 Months of a Two-Drug Regimen (Dolutegravir/Rilpivirine) for Treatment of HIV-1 in the United States." Open Forum Infectious Diseases 6, Supplement_2 (2019): S860—S861. http://dx.doi.org/10.1093/ofid/ofz360.2161.

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Abstract Background In 2017, the first complete antiretroviral regimen (ART) containing only two drugs, dolutegravir/rilpivirine (DTG/RPV), was approved for treatment of HIV-1 in virologically suppressed (<50 copies/mL) patients on a stable ART regimen for ≥6 months with no history of treatment failure/resistance to DTG or RPV. Our objective was to characterize early utilization/outcomes of DTG/RPV in a real-world population. Methods HIV-1+ individuals initiating DTG/RPV from January 1, 2018 to December 31, 2018 were identified in the OPERA Database. Outcomes were evaluated among the virolo
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Nachtkamp, Kathrin, Andrea Kuendgen, Barbara Hildebrandt, Norbert Gattermann, Rainer Haas, and Ulrich Germing. "Hematological Characteristics of Patients with Myelodysplastic Syndromes in the Light of WHO 2008 Proposals." Blood 112, no. 11 (2008): 1658. http://dx.doi.org/10.1182/blood.v112.11.1658.1658.

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Abstract Myelodysplastic syndromes have been reclassified by new WHO proposals published in 2008. So far, there are no data on haematological features of the newly composed subtypes. We analyzed 2063 patients with MDS diagnosed according to the WHO 2008 classification. Patients were characterized by their initial haematological features. We especially payed attention towards isolated cytopeniae with regard to the new classification of MDS subcategories. Analyses were performed by the use of the MDS registry Duesseldorf and included hemoglobin level, platelets, leukocytes and karyotype (availab
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Sneed, Penny K., Joe Mendez, Johanna G. M. Vemer-van den Hoek, et al. "Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors." Journal of Neurosurgery 123, no. 2 (2015): 373–86. http://dx.doi.org/10.3171/2014.10.jns141610.

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OBJECT The authors sought to determine the incidence, time course, and risk factors for overall adverse radiation effect (ARE) and symptomatic ARE after stereotactic radiosurgery (SRS) for brain metastases. METHODS All cases of brain metastases treated from 1998 through 2009 with Gamma Knife SRS at UCSF were considered. Cases with less than 3 months of follow-up imaging, a gap of more than 8 months in imaging during the 1st year, or inadequate imaging availability were excluded. Brain scans and pathology reports were reviewed to ensure consistent scoring of dates of ARE, treatment failure, or
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Abouyahya, Imane, Canan Alhan, Theresia M. Westers, Jan Koedam, Gert Ossenkoppele, and Arjan A. Van de Loosdrecht. "Treatment with Lenalidomide in Myelodysplastic Syndromes with 5q Deletion; Results From the Patient Named Program (PNP) in the Netherlands." Blood 118, no. 21 (2011): 5032. http://dx.doi.org/10.1182/blood.v118.21.5032.5032.

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Abstract Abstract 5032 Myelodysplastic syndromes (MDS) are a heterogeneous group of hematopoietic stem cell disorders characterized by dysplasia and cytopenia in one or more cell lineages. The WHO2001 classification recognizes MDS associated with del (5q) as a distinct entity. Previous data have shown that Lenalidomide can reduce transfusion requirements and reverse cytological and cytogenetic abnormalities in patients with MDS and del (5q). In this study we aimed to evaluate the efficacy of Lenalidomide in MDS patients with a del (5q) cytogenetic abnormality. Patients were eligible for inclus
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Ceraulo, Antony, Aminetou Mint-Mohamed, Delphine Maucort-Boulch, et al. "A Transcriptional- and Posttranscriptional-Based Prognostic Model in Pediatric Acute Myeloid Leukemia." Blood 128, no. 22 (2016): 2870. http://dx.doi.org/10.1182/blood.v128.22.2870.2870.

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Abstract Background. We have recently investigated transcriptional and posttranscriptional changes in AML cells (Oncotarget, 2016, 7, 2889-909) and identified ABCA3 expression, TET2 expression and TET2 exon 2 skipping (TET2E2S) as prognostic factors in pediatric AML (See companion abstracts from Ceraulo et al.). The present study was conducted in order to test whether the combination of these prognostic factors might help stratifying patients according to their relapse risk. Methods. Samples derived from 120 patients with available high-quality RNA and enrolled in the French ELAM2 protocol. Pa
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Liu, Jing, Yaming Wang, Xiaoyan Li, et al. "Immunohistochemical Profile and Prognostic Significance in Chinese Primary Central Nervous System Lymphoma: Analysis of 132 Cases." Blood 126, no. 23 (2015): 5026. http://dx.doi.org/10.1182/blood.v126.23.5026.5026.

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Abstract Primary central nervous system lymphoma (PCNSL) is aggressive and confined to the central nervous system, including the brain parenchyma, leptomeninges, spinal cord, eyes or cranial nervous. Morphologically, approximately 95% of these tumors are DLBCL according to the new World Health Organization (WHO) classification. However, PCNSL has treatment outcome distinct from those of systemic DLBCL, as well as dismal prognosis than systemic DLBCL. Our goal was to determine the immunohistochemical profile and prognostic significance for 132 Chinese PCNSL cases. The expression of CD20, CD10,
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Shah, Binay K., Krishna B. Ghimire, and Dinesh Pendharkar. "Survival Trends Among Very Elderly Patients with Advanced Diffuse Large B-Cell Lymphoma - a Population Based Study." Blood 124, no. 21 (2014): 2640. http://dx.doi.org/10.1182/blood.v124.21.2640.2640.

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Abstract Background Rituximab became commercially available in Novermber 1997. It was FDA approved in February 2006 for the first line treatment of patients with advanced diffuse large B cell lymphoma (DLBCL). The incidence of diffuse large B cell lymphoma increases with age, with >100 cases per 100000 persons aged >80 years. There is a limited data on survival very elderly patients with DLBCL. This study was conducted to evaluate survival trends of very elderly (≥80 years) patients with advanced DLBCL in the United States. Methods We selected very elderly patients (age ≥80 years) diagno
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Campbell, Andrew D., Raffaella Colombatti, Biree Andemariam, et al. "An Analysis of Racial and Ethnic Backgrounds within the Casire International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research." Blood 134, Supplement_1 (2019): 2305. http://dx.doi.org/10.1182/blood-2019-127613.

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Introduction: Millions are affected by Sickle Cell Disease (SCD) worldwide with the greatest burden in sub-saharan Africa. Its origin thought to lie within the malaria belt of the world, SCD continues to affect thousands of lives worldwide partly due to the migration patterns of the human race to different continents. We created the Consortium for the Advancement of Sickle Cell Research (CASiRe) to better understand the different phenotypes of SCD and compare the clinical profiles of patients living in different environments through a validated questionnaire and medical chart review, standardi
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Walker, Irwin, Aicha N. Traore, Alfonso Iorio, et al. "Ten-Year Canadian National Prospective Data On Utilization of Anti-Hemophilic Concentrates: Indications and Trends." Blood 120, no. 21 (2012): 1186. http://dx.doi.org/10.1182/blood.v120.21.1186.1186.

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Abstract Abstract 1186 Background: In response to the transfusion-transmitted AIDS epidemic the Commission of Inquiry on the Blood System in Canada recommended the development of a monitoring and tracking system of product usage. The Association of Hemophilia Clinic Directors of Canada (AHCDC) implemented the Canadian Hemophilia Assessment and Resource Management System (CHARMS) to track factor concentrates (FC) from the sole suppliers, Canadian Blood Services (CBS) and Hema-Quebec (HQ), to hospitals and to patients' homes. Objective: To identify the indications and locations for infusions of
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33

Schneider, Friederike, Annika Dufour, Tobias Benthaus, et al. "A New Molecular and Clinical Prognostic Score for Risk Stratification in CN-AML." Blood 114, no. 22 (2009): 2635. http://dx.doi.org/10.1182/blood.v114.22.2635.2635.

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Abstract Abstract 2635 Poster Board II-611 Background: Cytogenetically normal acute myeloid leukemia (CN-AML) is associated with an intermediate outcome. A number of clinical and molecular risk factors have been characterized pointing to the heterogeneity of this group. The purpose of the study was to define a prognostic model based on pre-treatment patient characteristics to facilitate choice of therapy by definition of patient groups with different prognoses. Patients and methods: We evaluated four molecular markers (mutations of NPM1, CEBPA, MLL-PTD; FLT3-ITD mutant level; interaction term
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Latagliata, Roberto, Dario Ferrero, Francesco Cavazzini, et al. "Imatinib In Very Elderly CML Patients: What Can We Achieve?." Blood 116, no. 21 (2010): 1229. http://dx.doi.org/10.1182/blood.v116.21.1229.1229.

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Abstract Abstract 1229 In the “real world” of clinical practice, many very elderly CML patients have been treated with imatinib (IM), but there are few data on the results and the best initial dosage in such patients. To highlight peculiar aspects of toxicity and efficacy of IM in this subset which accounts for at least 10–15% of all CML cases, we retrospectively revised 156 CML patients in chronic phase treated with IM when aged > 75 years from 23 haematological Institutions in Italy; there were 85 males and 71 females, median age at IM start was 78.4 years (IR 76.1 – 81.4), Sokal Risk at
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35

Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 850.1–850. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven
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36

Yurttas, B., B. C. Poyraz, N. Süt, et al. "POS1187 WILLINGNESS TO GET THE COVID-19 VACCINE AMONG PATIENTS WITH RHEUMATIC DISEASES, HEALTH WORKERS AND GENERAL POPULATION." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 875.1–875. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1435.

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Background:As of January 2021 the COVID-19 pandemic has been responsible for more than 2.2 million deaths worldwide (1). Potential vaccines against COVID-19 have been developed swiftly and vaccination programs were started in many countries. Turkey agreed to use inactivated vaccine candidate, ‘CoronaVac’ produced by Chinese biopharmaceutical company (3). Many of our patients having a rheumatic diseases (RD) call us for permission to get vaccination, while some express their concerns about the efficacy and safety issues.Objectives:We therefore assessed the willingness to get vaccination among p
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37

Tefferi, Ayalew, Terra L. Lasho, Christy Finke, et al. "Targeted Next-Generation Sequencing in Polycythemia Vera and Essential Thrombocythemia." Blood 126, no. 23 (2015): 354. http://dx.doi.org/10.1182/blood.v126.23.354.354.

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Abstract Background : Polycythemia Vera (PV) is associated with JAK2 mutations. In essential thrombocythemia (ET), ̴ 85% of patients harbor one of 3 "driver" mutations, with frequencies of ̴ 58%, 23% and 4%, for JAK2, CALR and MPL, respectively; ̴ 15% are wild type for all three mutations and are referred to as "triple negative". We applied next-generation sequencing (NGS) with a 27-gene panel of myeloid malignancy-relevant genes, in order to describe the prevalence of "non-driver" mutations and their prognostic relevance in PV and ET. Methods: Targeted capture assays were carried out on bone
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38

Yoon, Jae-Ho, Hee-Je Kim, Byung Sik Cho, et al. "High Post-Remission WT1 Expression Is a Predictive Marker for Subsequent Molecular Relapse and Poor Survival Outcome in Adult Patients with Acute Promyelocytic Leukemia (APL)." Blood 126, no. 23 (2015): 3842. http://dx.doi.org/10.1182/blood.v126.23.3842.3842.

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Abstract Background: Acute promyelocytic leukemia (APL) is classified into favorable-risk group and long-term overall survival (OS) is estimated at around 80%. Relapse rate of APL is relatively lower than another acute myeloid leukemia (AML) subtypes, but we still confront relapse in 10-20% and some relapsed cases are hardly cured even after hematopoietic cell transplantation (HCT). Therefore, it is important to find out patients with high-risk of relapse and early intervention should be considered. In APL, PML-RARa RQ PCR is used as a marker for residual disease, but the marker is not useful
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Schlenk, Richard F., Peter Frech, Sabine Kayser, et al. "Impact Of The Pretreatment Characteristics As Well As Cyto- and Molecular-Genetic Profile On Outcome After Relapse In Acute Myeloid Leukemia." Blood 122, no. 21 (2013): 830. http://dx.doi.org/10.1182/blood.v122.21.830.830.

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Abstract Background Cyto- and molecular-genetic abnormalities evaluated at initial diagnosis are the most powerful prognostic and in part also predictive markers in acute myeloid leukemia (AML) with regard to achievement of complete remission (CR) and survival. Nonetheless, after relapse the prognostic impact of clinical characteristics and genetic abnormalities assessed at initial diagnosis with respect to achievement of subsequent CR and survival are less clear. Aims To evaluate the probability of CR achievement and survival in relapsed AML patients in correlation to clinical characteristics
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40

Bartlett, S. J., C. Bingham, O. Schieir, et al. "POS1459-HPR IDENTIFYING MEANINGFUL CHANGE IN THE RA FLARE QUESTIONNAIRE SCORES IN RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1014–15. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1663.

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Background:The RA-FQ is a patient-reported measure of current disease activity in RA that can be used to identify disease flares. The RA-FQ queries pain, physical function, fatigue, stiffness, and participation and yields a score from 0-50. We previously reported on reliability, validity, and responsiveness.Objectives:To identify changes in RA-FQ that represent minimal and meaningful improvement or worsening from the perspective of people with RA, treating rheumatologists, and in relation to disease activity indices. We hypothesized thatMethods:Data were from adults with early RA (sx <1 yea
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41

Машкина, Екатерина Сергеевна. "Спектральный анализ тепловых флуктуаций в переходных областях предплавления KI". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 2 (2020): 238–44. http://dx.doi.org/10.17308/kcmf.2020.22/2837.

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В различных системах вблизи точек фазовых переходов наблюдаются неравновесные флуктуации по типу нелинейного броуновскго шума. Такие неравновесные процессы, как правило, являются предвестниками разрушения и деградации материалов. Наблюдение вблизи точки плавления Tm переходных явлений предплавления, аномальное поведение с температурой некоторых физических параметров, указывают на то, что по мере приближения к точке плавления структура и свойства твердого тела претерпевают изменения, как правило, нелинейно зависящие от скорости нагревания. Для характеристики состояния сложных динамических систе
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42

Burkhart, Scott O., Christine Ellis, and Troy M. Smurawa. "ACUTE PERFORMANCE ON A VESTIBULAR AND OCULAR MOTOR SCREENER AND RECOVERY FOLLOWING CONCUSSION." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0013. http://dx.doi.org/10.1177/2325967119s00136.

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Background: Concussion injuries are synonymous with vestibular impairments and symptoms include dizziness, impaired balance, and problems with gaze stability (Covassin et al., 2014). Common ocular motor impairments after a concussion include convergence/accommodative insufficiencies and saccadic dysfunction (Mucha et al., 2014). Vestibular and ocular motor impairments have been linked to worse outcomes following concussion (Pearce et al., 2015), including prolonged recovery (Corwin et al., 2015). The purpose of the current study was to determine which VOMS impairments were linked with longer r
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43

Thompson, Alexis A., Janet L. Kwiatkowski, John B. Porter та ін. "Favorable Outcomes in Pediatric Patients in the Phase 3 Hgb-207 (Northstar-2) and Hgb-212 (Northstar-3) Studies of Betibeglogene Autotemcel Gene Therapy for the Treatment of Transfusion-Dependent β-Thalassemia". Blood 136, Supplement 1 (2020): 52–54. http://dx.doi.org/10.1182/blood-2020-135857.

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Introduction Betibeglogene autotemcel (beti-cel; LentiGlobin for β-thalassemia) gene therapy is being evaluated for the treatment of transfusion-dependent β-thalassemia (TDT). Initial positive results of beti-cel in the phase 3 studies, HGB-207 (NCT02906202; non-β0/β0 genotypes) and HGB-212 (NCT03207009; β0/β0, β0/β+ IVS-I-110 and β+ IVS-I-110/β+ IVS-I-110 genotypes), showed 10/12 adult patients achieved transfusion independence. The studies expanded enrollment to include adolescents and children. We present interim results from pediatric patients <18 yrs who received beti-cel in HGB-20
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44

Cavo, Michele, Hartmut Goldschmidt, Laura Rosinol, et al. "Double Vs Single Autologous Stem Cell Transplantation for Newly Diagnosed Multiple Myeloma: Long-Term Follow-up (10-Years) Analysis of Randomized Phase 3 Studies." Blood 132, Supplement 1 (2018): 124. http://dx.doi.org/10.1182/blood-2018-99-112899.

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Abstract Introduction: Conflicting results from two recently reported randomized studies comparing double vs single autotransplantation (ASCT) for newly diagnosed multiple myeloma (MM) patients (pts) [(Cavo M et al, Blood 2017;130(1); Stadtmauer EA et al, Blood 2016;128(22)] are likely to reflect differences in the design of the trials. To address this controversial issue, we performed a long-term follow-up analysis of pt-level data from three phase 3 trials of bortezomib-thalidomide-dexamethasone (VTD) (Cavo M et al, Lancet 376; 2075-85, 2010; Rosinol L et al, Blood 120; 1589-96, 2012) or bor
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45

Hamidi, Hamidi, A. Wahab Jufri, and Wayan Karta. "PENGARUH KUALITAS KEHIDUPAN KERJA DAN KINERJA GURU TERHADAP KEPUASAN KERJA GURU SMA NEGERI DI KOTA MATARAM." Jurnal Ilmiah Profesi pendidikan 1, no. 1 (2016). http://dx.doi.org/10.29303/jipp.v1i2.14.

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Abstrak : Tujuan penelitian ini adalah untuk mengetahui pengaruh kualitas kehidupan kerja dan kinerja guru terhadap kepuasan kerja guru SMA Negeri di Kota Mataram. Penelitian ini merupakan penelitian kuantitatif dengan metode ex-post facto. Populasi penelitian ini adalah seluruh guru SMA Negeri di Kota Mataram yang berjumlah 580. Sampel penelitian berjumlah 85 guru yang diambil dengan teknik proportionate random sampling. Hasil penelitian adalah: 1) terdapat pengaruh kualitas kehidupan kerja sebesar 9,2% terhadap terhadap kepuasan kerja guru SMA Negeri di Kota Mataram, 2) terdapat pengaruh kin
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46

Pérez-Castilla, Alejandro, Amador García-Ramos, Luis Miguel Gijón-Nieto, Aitor Marcos-Blanco, and Felipe García-Pinillos. "Reliability and concurrent validity of the PUSH Band™ 2.0 to measure barbell velocity during the free-weight and Smith machine squat exercises." Proceedings of the Institution of Mechanical Engineers, Part P: Journal of Sports Engineering and Technology, July 5, 2021, 175433712110240. http://dx.doi.org/10.1177/17543371211024018.

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The aim of this study was to examine the test-retest reliability and concurrent validity of the PUSH Band™ 2.0 to measure barbell’s velocity during unconstrained (free-weights) and constrained (Smith machine) squat exercises. After an initial assessment of the Smith machine squat one-repetition maximum (1RM), 24 resistance-trained males completed one or two testing sessions separated by 7 days. In one session, the squat was performed with free-weights ( n = 22), while in another session, the Smith machine was used ( n = 16). Both testing sessions consisted of two blocks of eight repetitions (t
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47

Younis, Muhammad Umar, Syed Faraz-ul Hassan Shah, Aliya Muzafar, et al. "Needle stick injury reporting among surgeons in tertiary hospitals of Lahore." Professional Medical Journal 26, no. 06 (2019). http://dx.doi.org/10.29309/tpmj/2019.26.06.3593.

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Background: Needle stick injuries have a fairly common incidence in surgical practice exposing surgeons to an array of transmissible diseases. The aim of the study was to assess the prevalence of needle stick injury, and their reporting among surgeons in tertiary hospital setting. Study Design: Cross-sectional study. Setting: Various tertiary care hospital of Lahore. Period: January 2016 through April, 2016. Methods: Our sample size was 935 Surgeons. We determined the prevalence of needle stick injuries, reporting of NSI, the reasons for not reporting and the reasons for acquired injuries. Res
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48

Lahoz, R., A. Fagan, M. McSharry, C. Proudfoot, S. Corda, and R. Studer. "3267Impact of recurrent heart failure hospitalizations on cardiovascular mortality in subpopulations with atrial fibrillation and Type 2 diabetes mellitus in a UK database." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz745.0052.

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Abstract Background Previous studies have suggested that recurrent heart failure hospitalizations (HFh) are a predictor of cardiovascular (CV) and all-cause mortality. Patients with atrial fibrillation (AF) or type 2 diabetes mellitus (T2DM) may be at increased risk. Purpose This real-world study examined the impact of recurrent HFh on CV mortality in subgroups of patients with (i) AF or (ii) T2DM in the UK. Methods Adult HF patients identified in the CPRD database with a first (index) hospitalization due to HF recorded in the HES dataset from 01/01/2010 to 31/12/2014 and with a claim for AF o
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49

Gulliford, Martin C., A. Toby Prevost, Judith Charlton, et al. "Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial." BMJ, February 12, 2019, l236. http://dx.doi.org/10.1136/bmj.l236.

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Abstract Objectives To evaluate the effectiveness and safety at population scale of electronically delivered prescribing feedback and decision support interventions at reducing antibiotic prescribing for self limiting respiratory tract infections. Design Open label, two arm, cluster randomised controlled trial. Setting UK general practices in the Clinical Practice Research Datalink, randomised between 11 November 2015 and 9 August 2016, with final follow-up on 9 August 2017. Participants 79 general practices (582 675 patient years) randomised (1:1) to antimicrobial stewardship (AMS) interventi
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50

Salvador-Montanes, O., J. Fitzgerald, N. Jackson, et al. "Atrial fibrillation substrate mapping with decrement evoked potential mapping." EP Europace 23, Supplement_3 (2021). http://dx.doi.org/10.1093/europace/euab116.138.

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Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): Sociedad Española de Cardiologia. OnBehalf DEFINE-AF Background Identifying and targeting atrial substrate zones that are vulnerable to unidirectional block and slow conduction may be critical to improve the outcomes of atrial fibrillation (AF) ablation. Functional mapping of the atrial substrate with Decrement Evoked Potential (DeEP) and a single extrastimulus in this population could potentially lead to novel therapeutic strategies. Aim 1) To systematically analyze whether the DEEP are present in t
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