Relevant bibliographies by topics / 6-OHDA animal model

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Academic literature on the topic '6-OHDA animal model'

Author: Grafiati
Published: 5 September 2021
Last updated: 29 July 2025

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Journal articles on the topic "6-OHDA animal model"

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Barata-Antunes, Sandra, Fábio G. Teixeira, Bárbara Mendes-Pinheiro, et al. "Impact of Aging on the 6-OHDA-Induced Rat Model of Parkinson’s Disease." International Journal of Molecular Sciences 21, no. 10 (2020): 3459. http://dx.doi.org/10.3390/ijms21103459.

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Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. The neurodegeneration leading to incapacitating motor abnormalities mainly occurs in the nigrostriatal pathway due to the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Several animal models have been developed not only to better understand the mechanisms underlying neurodegeneration but also to test the potential of emerging disease-modifying therapies. However, despite aging being the main risk factor for developing idiopathic PD, most of the studies do not use aged animals.
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Kosksi, Tahsine, Arem Selmi, Sahar Mani, et al. "Antinociceptive effect of melatonin in the animal model of Parkinson’s Disease." Melatonin Research 4, no. 3 (2021): 440–52. http://dx.doi.org/10.32794/mr112500104.

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Several animal experimental and clinical studies have shown the effectiveness of melatonin in the treatment of some symptoms of Parkinson's disease (PD). However, the antinociceptive effect of melatonin against pain associated to PD has not been fully investigated. Thus, the present study investigated the possible antiallodynic and antinociceptive effects of acute and chronic melatonin treatments in Parkinsonian model of rats. This model was created by unilateral injection of 6-hydroxydopamine (6-OHDA) into the left medial forebrain bundle (MFB). The electronic von Frey test was used t
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Morris, Jill K., Gregory L. Bomhoff, John A. Stanford, and Paige C. Geiger. "Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 299, no. 4 (2010): R1082—R1090. http://dx.doi.org/10.1152/ajpregu.00449.2010.

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Despite numerous clinical studies supporting a link between type 2 diabetes (T2D) and Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to address the relationship between insulin resistance and nigrostriatal dopamine (DA) in a preclinical animal model. High-fat feeding in rodents is an established model of insulin resistance, characterized by increased adiposity, systemic oxidative stress, and hyperglycemia. We subjected rats to a normal chow or high-fat diet for 5 wk before infusing 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Our goal
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Song, Dan, Kangli Ma, Alexei Verkhratsky, and Liang Peng. "l-Dopa and Fluoxetine Upregulate Astroglial 5-HT2B Receptors and Ameliorate Depression in Parkinson’s Disease Mice." Neuroglia 1, no. 1 (2018): 48–62. http://dx.doi.org/10.3390/neuroglia1010006.

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Here, we report the association between depressive behavior (anhedonia) and astroglial expression of 5-hydroxytryptamine receptor 2B (5-HT2B) in an animal model of Parkinson’s disease, induced by bilateral injection of 6-hydroxydopamine (6-OHDA) into the striatum. Expression of the 5-HT2B receptor at the mRNA and protein level was decreased in the brain tissue of 6-OHDA-treated animals with anhedonia. Expression of the 5-HT2B receptor was corrected by four weeks treatment with either l-3,4-dihydroxyphenylalanine (l-dopa) or fluoxetine. Simultaneously, treatment with l-dopa abolished 6-OHDA eff
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Austin, Publishing Group. "The Neuroprotective Effect of Clove Essential Oil Against 6-Ohda-Induced Cell Death in Sh-Sy5y and A Rat Model of Parkinson's Disease." Austin Alzheimer's and Parkinson's Disease 6, no. 2 (2023): 1039. https://doi.org/10.26420/austinalzheimersjparkinsonsdis.2023.1039.

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Abstract Parkinson’s Disease (PD) is the second most prevalent neurological disorder. Natural therapies are becoming more popular for preventing disease onset. Clove Essential Oil (CEO), a potent antioxidant derived from Syzygium aromaticum buds, was tested in vitro (SH-SY5Y) and in vivo (PD rat model) for its ability to protect against 6-OHDA-induced cell death. Twenty-four hours of SH-SY5Y cells’ exposure to 6-OHDA (100μM) drastically decreased cell viability. At doses lesser than 20μg/ml, CEO and its main component Eugenol (EG) had no cytotoxic effect on SH-SY5Y. CEO and E
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Kim, Bohye, Poornima D. E. Weerasinghe-Mudiyanselage, Mary Jasmin Ang, et al. "Changes in the Neuronal Architecture of the Hippocampus in a 6-Hydroxydopamine-Lesioned Rat Model of Parkinson Disease." International Neurourology Journal 26, Suppl 2 (2022): S94–105. http://dx.doi.org/10.5213/inj.2244252.126.

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Purpose: Parkinson disease (PD) is a progressive neurodegenerative disorder in which dopaminergic (DAergic) systems are destroyed (particularly in the nigrostriatal system), causing both motor and nonmotor symptoms. Hippocampal neuroplasticity is altered in PD animal models, resulting in nonmotor dysfunctions. However, little is known about the precise mechanism underlying the hippocampal dysfunctions in PD.Methods: Striatal 6-hydroxydopamine (6-OHDA) infusions were performed unilaterally in adult Sprague Dawley rats. Both motor and nonmotor symptoms alongside the expression of tyrosine hydrox
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Dantas, Camila G., Ailma O. da Paixão, Tássia L. G. M. Nunes, et al. "Africanized Bee Venom (Apis mellifera Linnaeus): Neuroprotective Effects in a Parkinson’s Disease Mouse Model Induced by 6-hydroxydopamine." Toxics 10, no. 10 (2022): 583. http://dx.doi.org/10.3390/toxics10100583.

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This study evaluated the neuroprotective effects of the Africanized bee venom (BV) and its mechanisms of action after 6-hydroxydopamine-(6-OHDA)-induced lesion in a mice model. Prior to BV treatment, mice received intrastriatal microinjections of 6-OHDA (no induced dopaminergic neuronal death) or ascorbate saline (as a control). BV was administered subcutaneously at different dosages (0.01, 0.05 or 0.1 mg·Kg−1) once every two days over a period of 3 weeks. The open field test was carried out, together with the immunohistochemical and histopathological analysis. The chemical composition of BV w
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Ariza, D., L. Sisdeli, C. C. Crestani, R. Fazan, and M. C. Martins-Pinge. "Dysautonomias in Parkinson's disease: cardiovascular changes and autonomic modulation in conscious rats after infusion of bilateral 6-OHDA in substantia nigra." American Journal of Physiology-Heart and Circulatory Physiology 308, no. 3 (2015): H250—H257. http://dx.doi.org/10.1152/ajpheart.00406.2014.

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It is important to elucidate the mechanism of dysautonomias in patients with Parkinson's disease; therefore, this study aimed to investigate the cardiovascular and autonomic changes that occur in an animal model of Parkinsonism. Adult male Wistar rats were anesthetized before bilateral microinfusions of 6-hydroxydopamine (6-OHDA) into the substantia nigra. The sham group underwent the same surgical procedure but received vehicle. After 7 days, the mean arterial pressure (MAP) and heart rate (HR) were measured, and various drugs were injected into conscious rats through cannulas previously impl
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Xie, Caroline, and Asheeta A. Prasad. "Probiotics Treatment Improves Hippocampal Dependent Cognition in a Rodent Model of Parkinson’s Disease." Microorganisms 8, no. 11 (2020): 1661. http://dx.doi.org/10.3390/microorganisms8111661.

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Parkinson’s disease (PD) is a neurological disorder with motor dysfunction and a number of psychiatric symptoms. Symptoms such as anxiety and cognitive deficits emerge prior to motor symptoms and persist over time. There are limited treatments targeting PD psychiatric symptoms. Emerging studies reveal that the gut microbe is altered in PD patients. Here we assessed the effect of a probiotic treatment in a rat model of PD. We used the neurotoxin (6-hydroxydopamine, 6-OHDA) in a preclinical PD model to examine the impact of a probiotic treatment (Lacticaseibacillus rhamnosus HA-114) on anxiety a
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Masini, Débora, Carina Plewnia, Maëlle Bertho, Nicolas Scalbert, Vittorio Caggiano, and Gilberto Fisone. "A Guide to the Generation of a 6-Hydroxydopamine Mouse Model of Parkinson’s Disease for the Study of Non-Motor Symptoms." Biomedicines 9, no. 6 (2021): 598. http://dx.doi.org/10.3390/biomedicines9060598.

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In Parkinson’s disease (PD), a large number of symptoms affecting the peripheral and central nervous system precede, develop in parallel to, the cardinal motor symptoms of the disease. The study of these conditions, which are often refractory to and may even be exacerbated by standard dopamine replacement therapies, relies on the availability of appropriate animal models. Previous work in rodents showed that injection of the neurotoxin 6-hydroxydopamine (6-OHDA) in discrete brain regions reproduces several non-motor comorbidities commonly associated with PD, including cognitive deficits, depre
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Dissertations / Theses on the topic "6-OHDA animal model"

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Carvalho, Kárin Santana de. "Alterações na glia observadas em regiões encefálicas envolvidas no controle respiratório em um modelo animal da doença de Parkinson." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-15022018-171401/.

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A doença de Parkinson (DP) apresenta declínio da capacidade respiratória. Estudo utilizando um modelo de DP induzido pela injeção de 6-hidroxidopamina (6-OHDA) no estriado mostrou redução no número de neurônios envolvidos no controle da respiração. O objetivo desse estudo foi avaliar alterações gliais no núcleo retrotrapezóide (RTN), núcleo do trato solitário, complexo pré-Bötzinger e grupamento respiratório ventrolateral rostral (rVRG) utilizando o mesmo modelo experimental. Em ratos Wistar que receberam a injeção de 6-OHDA bilateralmente no estriado observou-se redução na imunorreatividade p
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Gradowski, Raisa Wendhausen. "Efeito tipo-antidepressivo da curcumina no modelo animal da 6-OHDA de Doença de Parkinson." reponame:Repositório Institucional da UFPR, 2013. http://hdl.handle.net/1884/32035.

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Resumo: Um dos sintomas não motores mais comuns na Doença de Parkinson (DP) é a depressão, que afeta aproximadamente 35% dos pacientes e pode levar a uma redução significativa da qualidade de vida dos mesmos. A curcumina, o principal composto ativo da Curcuma longa (tumeric), vem apresentando diversas propriedades farmacológicas como atividade anti-inflamatória, inibidora da monoaminooxidase (MAO) e efeitos neuroprotetores. Este composto já tem sido extensivamente estudado em vários modelos de depressão e, mais recentemente, em modelos de DP. Mas nada é sabido sobre seus efeitos na depressão a
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Telkes, Ilknur. "Phase Validation Of Neurotoxic Animal Models Of Parkinson." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614866/index.pdf.

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Parkinson&rsquo<br>s disease (PD) is characterized by the progressive loss of dopaminergic nigral neurons and striatal dopamine resulting in serious motor deficits but also some non-motor anomalies. Animal models of human neurodegenerative diseases are essential for better understanding their pathogenesis and developing efficient therapeutic tools. There are many different PD models, however, none of them is fully reproducing all the symptoms of the disease. In addition, different investigators use different behavioral measures which makes even more difficult to compare and evaluate the result
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Stenslik, Mallory J. "The Intranasal Delivery of DNSP-11 and its Effects in Animal Models of Parkinson's Disease." UKnowledge, 2015. https://uknowledge.uky.edu/neurobio_etds/14.

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A major challenge in developing disease altering therapeutics for the treatment of Parkinson’s disease (PD) has been the delivery of compounds across the blood-brain barrier (BBB) to the central nervous system (CNS). While direct surgical infusion has been utilized to deliver compounds to the brain that don’t cross the BBB, issues of poor biodistribution in the CNS due in part to properties of the molecules being delivered and/or infusion device protocols have limited the widespread success of this invasive approach. To avoid the issues of surgically delivering compounds to the CNS, numerous s
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Batassini, Cristiane. "Avaliação do potencial terapêutico da guanosina em um modelo animal da doença de Parkinson induzido por 6-OHDA." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2010. http://hdl.handle.net/10183/24166.

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A Doença de Parkinson (DP) é uma doença multifatorial. Seu tratamento é apenas sintomático, o que salienta a importância do estudo de novas terapias. Há evidências de que a excitotoxicidade atribuída ao aumento da atividade glutamatérgica nos núcleos da base seja uma das causas da DP. A guanosina extracelular tem efeitos sobre parâmetros glutamatérgicos e é neuroprotetora: quando administrada oralmente, ela protege ratos contra convulsões induzidas por ácido quinolínico, bem como protege fatias de hipocampo submetidas à combinação de hipóxia e hipoglicemia. O objetivo deste trabalho foi invest
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Vecchia, Débora Dalla. "Efeito da cetamina em sintomas motores e não motores da doença de Parkinson no modelo animal de 6-OHDA." reponame:Repositório Institucional da UFPR, 2017. http://hdl.handle.net/1884/47972.

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Orientador : Prof. Dr. Roberto Andreatini<br>Coorientador : Prof. Dr. Edmar Miyoshi<br>Tese (doutorado) - Universidade Federal do Paraná, Setor de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia. Defesa: Curitiba, 24/02/2017<br>Inclui referências : f. 71-85<br>Resumo: A Doença de Parkinson (DP) se caracteriza pela perda progressiva de neurônios dopaminérgicos da substância negra pars compacta (SNpc), levando a redução de dopamina em toda a via nigroestriatal. Esse é o principal mecanismo fisiopatológico envolvido com o desenvolvimento dos sintomas motores da doença. Entre esses
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Victoria, Sosti María. "Caracterización molecular y determinación del perfil cognitivo de modelos de parkinsonismo en rata inducidos por 6-OHDA." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/129402.

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El presente trabajo expone la caracterización molecular y el perfil cognitivo de modelos de parkinsonismo en rata con degeneración dopaminérgica nigroestriatal mediante la inyección estereotáxica de 6-hidroxidopamina (6-OHDA) en el haz prosencefálico medial (i.e MFB). Para ello se utilizaron dos modelos : (i ) lesión dopaminérgica unilateral y (ii) modelo de lesión dopaminérgica bilateral asimétrica. En el modelo de lesión unilateral se observa una mayor pérdida de inmunorreactividad frente a la tirosina hidroxilasa en la sustancia nigra pars compacta (SNpc) respecto al área tegmental v
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Silvestrin, Roberta Bristot. "O Teste de motricidade sobre grade como ferramenta de triagem no modelo de parkinsonismo induzido por 6-hidroxidopamina em ratos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2008. http://hdl.handle.net/10183/15007.

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A infusão de 6-hidroxidopamina (6-OHDA) na via nigroestriatal em ratos é um modelo da Doença de Parkinson (DP). O Teste de Motricidade sobre Grade (TMG ou, em inglês, footfault test) é um teste comportamental utilizado para avaliar a função motora em ratos. Observamos que animais lesionados unilateralmente com 6-OHDA mostram atividade rotacional ipsilateral induzida pelo contexto quando colocados no aparato do TMG por 3 minutos e isso pode ser utilizado como índice para detectar animais lesionados. Nossos resultados mostraram que o TMG tem sensibilidade e especificidade de 100% para lesões mai
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Dutra, Márcio Ferreira. "Efeitos do exercício físico sobre a expressão da proteína glial fibrilar ácida (GFAP) e comportamento motor de ratos submetidos ao modelo de doença de Parkinson induzida por 6-OHDA." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2009. http://hdl.handle.net/10183/17417.

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The aim of this study was to investigate whether exercise could improve motor behavioral deficits and alter expression of glial fibrillary acidic protein (GFAP) in dorsal striatum in a 6-hydroxydopamine (6-OHDA) rat model of Parkinson’s disease (PD). To this end, animals were randomly divided into 4 groups: sham sedentary (SS, n = 7); sham trained (ST, n=8); lesioned sedentary (LS, n=8) and lesioned trained (LT, n = 8). Rats were unilaterally lesioned with 6-OHDA (10 μg/3 μg) injected into the left medial forebrain bundle and sham groups were only injected with vehicle solution. The treadmill
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Silva, Sofia Cristóvão Alves Fernandes da. "Comprehensive characterization of the brain proteome of a 6-OHDA animal model: new insights into Parkinson's disease." Master's thesis, 2019. http://hdl.handle.net/10316/88141.

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Dissertação de Mestrado Integrado em Engenharia Biomédica apresentada à Faculdade de Ciências e Tecnologia<br>Parkinson's disease (PD) is a common neurodegenerative disorder associated with motor and cognitive impairments. It is characterized by dopaminergic neurodegeneration in the nigrostriatal budle, which has repercussions to other brain regions producing the motor (parkinsonism) and non-motor symptomatology characteristic of PD. Research efforts have been directed toward understanding the etiology and pathogenesis of PD in the hope of developing a more effective therapy that will slow or
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Book chapters on the topic "6-OHDA animal model"

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Rosa Avila-Costa, Maria, José Luis Ordoñez-Librado, Ana Luisa Gutierréz-Valdez, et al. "Behavioral and Cytological Differences between Two Parkinson’s Disease Experimental Models." In Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.108268.

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The knowledge about the biochemical and behavioral changes in humans with PD has allowed proposing animal models for its study; however, the results obtained so far have been heterogeneous. Recently, we established a novel PD model in rodents by manganese chloride (MnCl2) and manganese acetate (Mn (OAc)3) mixture inhalation. After inhaling, the rodents presented bilateral loss of SNc dopaminergic neurons. Later, we conclude that the alterations are of dopamine origin since L-DOPA reverted the alterations. After six months, SNc significantly reduced the number of cells, and striatal dopamine co
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Takakura, Ana C., Thiago S. Moreira, and Barbara Falquetto. "6-Hydroxydopamine (6-OHDA) rodent model of Parkinson’s disease: Investigating neural control of cardiorespiratory function." In Handbook of Animal Models in Neurological Disorders. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-89833-1.00046-x.

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