Log in

Relevant bibliographies by topics / 6-substituted pteridine-2

Contents

Journal articles

Academic literature on the topic '6-substituted pteridine-2'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic '6-substituted pteridine-2.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "6-substituted pteridine-2"

1

Sokolova, K.V., V.V. Stavytskyi, S.I. Kovalenko, and O.A. Podpletnya. "Directed search for diuretics among 6-substituted pteridine-2,4,7(1H,3H,8H)-triones." Medicni perspektivi 27, no. 2 (2022): 4–15. https://doi.org/10.26641/2307-0404.2022.2.260051.

Full text

Abstract:

Directed search for biologically active compounds among heterocycles still remains a relevant area of medical chemistry. Among the significant number of heterocyclic compounds, pteridines deserve special attention. Among the above-mentioned ones the drugs with antitumor, antimicrobial, antiviral, diuretic and other types of biological action are known. Nevertheless, 6-substituted pteridine-2,4,7(1H,3H,8H)-triones, which are structurally similar to triamterene (6-phenylpteridine-2,4,7-triamine) – a diuretic with potassium-sparing action are interesting objects for search for diuretics. Al

APA, Harvard, Vancouver, ISO, and other styles

2

Reibnegger, Gilbert, Brian J. Denny, and Helmut Wachter. "Ab Initio Quantum Chemical Calculations on the Stability of Different Tautomers of 6- and 7-Phenacetyl Pterin." Pteridines 4, no. 1 (1993): 23–26. http://dx.doi.org/10.1515/pteridines.1993.4.1.23.

Full text

Abstract:

Summary In order to investigate the stabilities of different tautomeric forms of pteridine derivatives with a phenacetyl side chain in the 6- or 7-position, we have performed ab initio quantum chemical geometry optimizations of both the keto form and the vinylogous amide form of 6- and 7-phenacetyl pterin. The results are in accordance with experimental expectations: the keto form is slightly more stable for the 6-substituted derivative (1 .8 kcal per mol). while the vinylogous amide form is substantially more stable for the 7-substituted compound (8 .7 kcal per mol). The vinylogous amide form

APA, Harvard, Vancouver, ISO, and other styles

3

Suling, William J., Lainne E. Seitz, Vibha Pathak, et al. "Antimycobacterial Activities of 2,4-Diamino-5-Deazapteridine Derivatives and Effects on Mycobacterial Dihydrofolate Reductase." Antimicrobial Agents and Chemotherapy 44, no. 10 (2000): 2784–93. http://dx.doi.org/10.1128/aac.44.10.2784-2793.2000.

Full text

Abstract:

ABSTRACT Development of new antimycobacterial agents for Mycobacterium avium complex (MAC) infections is important particularly for persons coinfected with human immunodeficiency virus. The objectives of this study were to evaluate the in vitro activity of 2,4-diamino-5-methyl-5-deazapteridines (DMDPs) against MAC and to assess their activities against MAC dihydrofolate reductase recombinant enzyme (rDHFR). Seventy-seven DMDP derivatives were evaluated initially for in vitro activity against one to three strains of MAC (NJ168, NJ211, and/or NJ3404). MICs were determined with 10-fold dilutions

APA, Harvard, Vancouver, ISO, and other styles

4

Gonçalves, Raquel C. R., Filipe Teixeira, Pablo Peñalver, Susana P. G. Costa, Juan C. Morales, and M. Manuela M. Raposo. "Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computational and In Vitro Assessment." Molecules 29, no. 9 (2024): 2072. http://dx.doi.org/10.3390/molecules29092072.

Full text

Abstract:

Leishmaniasis and Human African trypanosomiasis pose significant public health threats in resource-limited regions, accentuated by the drawbacks of the current antiprotozoal treatments and the lack of approved vaccines. Considering the demand for novel therapeutic drugs, a series of BODIPY derivatives with several functionalizations at the meso, 2 and/or 6 positions of the core were synthesized and characterized. The in vitro activity against Trypanosoma brucei and Leishmania major parasites was carried out alongside a human healthy cell line (MRC-5) to establish selectivity indices (SIs). Not

APA, Harvard, Vancouver, ISO, and other styles

5

Nakanishi, A., M. Goto, S. Katoh, and T. Sueoka. "6-Acetonylisoxanthopterin: A Potent Inhibitor of Sepiapterin Reductase." Pteridines 3, no. 3 (1991): 165–66. http://dx.doi.org/10.1515/pteridines.1991.3.3.165.

Full text

Abstract:

The inhibitory effect of 6-/7-substituted (2'-oxo) pteridines and ichthyopterin was examined for sepiapterin reductase. 6-Acetonylisoxanthopterin and 6-acetonyl-2,4-diamino-7-hydroxypteridine showed pronounced competitive inhibitory effects to sepiapterin reductase and Ki values were 0.38 μM and 90 μM, respectively. Ichthyopterin and 6-acetonyl-7-hydroxylumazine showed weak noncompetitive inhibitory effects and Ki values were 2.4 mM and 1.1 mM, respectively. 7-Acetonylxanthopterin exhibited no inhibition to sepiapterin reductase.

APA, Harvard, Vancouver, ISO, and other styles

6

Fun, Hoong-Kun, Shyamaprosad Goswami, Annada C. Maity, Sibaprasad Maity, and Suchada Chantrapromma. "N-(7-Dimethoxymethyl-4-oxo-3,4-dihydropteridin-2-yl)-2,2-dimethylpropionamide monohydrate." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4249—o4250. http://dx.doi.org/10.1107/s1600536807047940.

Full text

Abstract:

In the title compound, C14H19N5O4·H2O, the 3,4-dihydropteridine ring system deviates sigificantly from planarity, the dihedral angle between the mean planes of the two rings being 3.93 (9)°. Intramolecular N—H...O hydrogen bonding generates an S(6) ring motif. The water molecule forms O—H...O and O—H...N intramolecular hydrogen bonds with the substituted pteridine molecule. In the crystal structure, the substituted pteridine molecules are linked by N—H...N hydrogen bonds into chains running along the c direction. These chains are further connected to the water molecules by N—H...O, O—H...O and

APA, Harvard, Vancouver, ISO, and other styles

7

Nielsen, P., and A. Bacher. "Biosynthesis of Riboflavin. A Simple Synthesis of the Substrate and Product of the Pyrimidine Deaminase and of Structural Analogs." Zeitschrift für Naturforschung B 43, no. 10 (1988): 1358–64. http://dx.doi.org/10.1515/znb-1988-1025.

Full text

Abstract:

2-Amino-5-nitro-6-ribitylamino-4(3H)-pyrimidinone (7) was phosphorylated with chlorophosphoric acid yielding an isomer mixture containing about 63% of the 5´-phosphate 7a together with other monophosphates and bisphosphates of 7. Preparative HPLC afforded pure 7a. Catalytic hydrogenation of 7a yields the labile substrate of pyrimidine deaminase, 2,5-diamino-6-ribityl-amino-4(3H)-pyrimidinone 5´-phosphate (2a). The product of the enzyme, 5-amino-6-ribityl-amino-2,4(1H,3H)-pyrimidinedione 5´-phosphate (4a), can be obtained from 5-nitro-6-ribityl-amino-2,4(1H,3H)-pyrimidinedione (8) by an analogo

APA, Harvard, Vancouver, ISO, and other styles

8

Rosowsky, Andre, Ronald A. Forsch, Sherry F. Queener, and Joseph R. Bertino. "Synthesis of 2,4-Diaminopteridines with Bulky Lipophilic Groups at the 6-Position as Inhibitors of Pneumocystis carinii, Toxoplasma gondii, and Mammalian Dihydrofolate Reductase." Pteridines 8, no. 3 (1997): 173–87. http://dx.doi.org/10.1515/pteridines.1997.8.3.173.

Full text

Abstract:

SummaryTen previously undescribed 2,4-diamino-6-(2-naphthylamino )methylpteridines with lipophilic chlorine or long-chain alkyl groups on the naphthyl moiety and either hydrogen or a methyl group on N 10 were synthesized from the appropriate 2-naphthylamine or N-methyl-2-naphthylamine by reaction with 2-amino-5-chloromethylpyrazine-3-carbonitrile and ring closure with guanidine . One analogue with a methyl group at the 7 -position was also prepared. The N 10 -unsubstituted analogues were consistently less active than the N1o-methyl analogues as inhibitors of Pneumocystis carin ii, Toxoplasma g

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!