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1

Klugmann, T., and B. Bokemeyer. "Langzeit-Verträglichkeit der 6-Thioguanin- Therapie bei CED-Patienten in der gastroenterologischen Fachpraxis." Verdauungskrankheiten 23, no. 07 (2005): 181–85. http://dx.doi.org/10.5414/vdp23181.

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2

Haas, R., A. Mundinger, T. Bohn, K. Schaz, and W. Hunstein. "Therapiemöglichkeiten beim Hypereosinophilie-Syndrom mit Endomyocarditis fibroplastica Löffler: Wirksamkeit von Cytarabin und 6-Thioguanin." DMW - Deutsche Medizinische Wochenschrift 110, no. 41 (2008): 1573–76. http://dx.doi.org/10.1055/s-2008-1069049.

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3

Abrahamsson, Jonas, Erik Forestier, Jesper Heldrup, et al. "Response-Guided Induction Therapy in Pediatric Acute Myeloid Leukemia With Excellent Remission Rate." Journal of Clinical Oncology 29, no. 3 (2011): 310–15. http://dx.doi.org/10.1200/jco.2010.30.6829.

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Purpose To evaluate the early treatment response in children with acute myeloid leukemia (AML) using a response-guided induction strategy that includes idarubicin in the first course. Patients and Methods All Nordic children with AML younger than 15 years (n = 151) were treated on the Nordic Society for Pediatric Hematology and Oncology (NOPHO) AML 2004 protocol. After the first course of idarubicin, cytarabine, etoposide, and 6-thioguanin, patients with good response were allowed hematologic recovery before the second course, whereas patients with a poor (≥ 15% blasts) or intermediate (5% to
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4

Herrlinger, Klaus R., Matthias Schwab, Klaus Fellermann, and Eduard F. Stange. "6-thioguanine-buried alive?" Gastroenterology 126, no. 3 (2004): 940–41. http://dx.doi.org/10.1053/j.gastro.2004.01.044.

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5

Feistner, Gottfried, and Carle M. Staub. "6-Thioguanine fromErwinia amylovora." Current Microbiology 13, no. 2 (1986): 95–101. http://dx.doi.org/10.1007/bf01568289.

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6

Josting, Andreas, Sabine Wiedenmann, Jeremy Franklin, et al. "Secondary Myeloid Leukemia and Myelodysplastic Syndromes in Patients Treated for Hodgkin’s Disease: A Report From the German Hodgkin’s Lymphoma Study Group." Journal of Clinical Oncology 21, no. 18 (2003): 3440–46. http://dx.doi.org/10.1200/jco.2003.07.160.

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Purpose: To assess the incidence and outcome of secondary acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) in patients with Hodgkin’s disease (HD). Patients and Methods: Between 1981 and 1998, the GHSG conducted three trial generations for early, intermediate, and advanced HD involving a total of 5,411 patients (called HD1 through HD9). Results: A total of 46 patients with secondary AML/MDS were identified. The median age at diagnosis of leukemia was 47 years (range, 22 to 79 years). Primary therapy was as follows: radiotherapy alone (n = 4); doxorubicin, bleomycin, vinblastine,
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7

Kraske, P. J., and Brajter-Toth. "Electrochemical oxidation of 6-thioguanine." Journal of Electroanalytical Chemistry and Interfacial Electrochemistry 207, no. 1-2 (1986): 101–16. http://dx.doi.org/10.1016/0022-0728(86)87065-6.

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8

Sherer, Daniel W., and Mark G. Lebwohl. "6-Thioguanine in the Treatment of Psoriasis: A Case Report and Literature Review." Journal of Cutaneous Medicine and Surgery 6, no. 6 (2002): 546–50. http://dx.doi.org/10.1177/120347540200600605.

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Background: 6-Thioguanine is a purine analog primarily indicated for acute myelogenous leukemia. Its use in psoriasis was first investigated in the 1950s and current interest in serious treatments for psoriasis, such as cyclosporine, has renewed interest in this medication. Newer therapies, such as PUVA and retinoids, have side effects as do some older treatments, such as methotrexate, which fell into favor at the same time 6-thioguanine was being investigated. Reexamining older treatments can open up new therapeutic options in difficult cases. Objective: The goal of this article is to provide
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9

Wensing, A., M. Gernold, S. Jock, et al. "6-THIOGUANINE BIOSYNTHESIS IN ERWINIA SPECIES." Acta Horticulturae, no. 1056 (October 2014): 165–67. http://dx.doi.org/10.17660/actahortic.2014.1056.25.

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10

Siouri, Faady M., Samuel Boldissar, Jacob A. Berenbeim, and Mattanjah S. de Vries. "Excited State Dynamics of 6-Thioguanine." Journal of Physical Chemistry A 121, no. 28 (2017): 5257–66. http://dx.doi.org/10.1021/acs.jpca.7b03036.

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11

Manikowski, Andrzej, and Jerzy Boryski. "Transglycosylation Reactions of 6-Thioguanine Acyclonucleosides." Nucleosides, Nucleotides and Nucleic Acids 19, no. 10-12 (2000): 1569–80. http://dx.doi.org/10.1080/15257770008045447.

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12

Zackheim, Herschel S., and Howard I. Maibach. "TREATMENT OF PSORIASIS WITH 6-THIOGUANINE." Australasian Journal of Dermatology 29, no. 3 (1988): 163–67. http://dx.doi.org/10.1111/j.1440-0960.1988.tb00391.x.

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13

Ono, Akira, Takahiro Atsugi, Misato Goto, et al. "Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione." RSC Advances 9, no. 40 (2019): 22859–62. http://dx.doi.org/10.1039/c9ra03515j.

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14

Kretz, K. A., J. R. Katze, and R. W. Trewyn. "Guanine analog-induced differentiation of human promyelocytic leukemia cells and changes in queuine modification of tRNA." Molecular and Cellular Biology 7, no. 10 (1987): 3613–19. http://dx.doi.org/10.1128/mcb.7.10.3613.

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Treatment of hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-deficient human promyelocytic leukemia (HL-60) cells with 6-thioguanine results in growth inhibition and cell differentiation. 6-Thioguanine is a substrate for the tRNA modification enzyme tRNA-guanine ribosyltransferase, which normally catalyzes the exchange of queuine for guanine in position 1 of the anticodon of tRNAs for asparagine, aspartic acid, histidine, and tyrosine. During the early stages of HGPRT-deficient HL-60 cell differentiation induced by 6-thioguanine, there was a transient decrease in the queuine content of
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15

Kretz, K. A., J. R. Katze, and R. W. Trewyn. "Guanine analog-induced differentiation of human promyelocytic leukemia cells and changes in queuine modification of tRNA." Molecular and Cellular Biology 7, no. 10 (1987): 3613–19. http://dx.doi.org/10.1128/mcb.7.10.3613-3619.1987.

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Treatment of hypoxanthine-guanine phosphoribosyltransferase (HGPRT)-deficient human promyelocytic leukemia (HL-60) cells with 6-thioguanine results in growth inhibition and cell differentiation. 6-Thioguanine is a substrate for the tRNA modification enzyme tRNA-guanine ribosyltransferase, which normally catalyzes the exchange of queuine for guanine in position 1 of the anticodon of tRNAs for asparagine, aspartic acid, histidine, and tyrosine. During the early stages of HGPRT-deficient HL-60 cell differentiation induced by 6-thioguanine, there was a transient decrease in the queuine content of
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16

Leszczynski, Jerzy. "Tautomers of 6-thioguanine: structures and properties." Journal of Physical Chemistry 97, no. 14 (1993): 3520–24. http://dx.doi.org/10.1021/j100116a014.

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17

LeLeiko, Neal S., Debra Lobato, Sarah Hagin, et al. "6-Thioguanine Levels in Pediatric IBD Patients." Inflammatory Bowel Diseases 19, no. 12 (2013): 2652–58. http://dx.doi.org/10.1097/01.mib.0000436960.00405.56.

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18

Larrey, D., E. Freneaux, A. Berson, et al. "Peliosis hepatis induced by 6-thioguanine administration." Gut 29, no. 9 (1988): 1265–69. http://dx.doi.org/10.1136/gut.29.9.1265.

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19

Singh, Kamalendra, R. A. Yadav, and J. S. Yadav. "Vibrational studies of biomolecules—III. 6-Thioguanine." Spectrochimica Acta Part A: Molecular Spectroscopy 47, no. 6 (1991): 819–20. http://dx.doi.org/10.1016/0584-8539(91)80154-b.

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20

Barek, Jiří, Antonín Berka, Ludmila Dempírová, and Jiří Zima. "Polarographic and voltammetric determination of 6-mercaptopurine and 6-thioguanine." Collection of Czechoslovak Chemical Communications 51, no. 11 (1986): 2466–72. http://dx.doi.org/10.1135/cccc19862466.

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Conditions were found for the determination of 6-mercaptopurine (I) and 6-thioguanine (II) by TAST polarography, differential pulse polarography and fast-scan differential pulse voltammetry at a hanging mercury drop electrode. The detection limits were 10-6, 8 . 10-8, and 6 . 10-8 mol l-1, respectively. A further lowering of the detection limit to 2 . 10-8 mol l-1 was attained by preliminary accumulation of the determined substances at the surface of a hanging mercury drop.
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21

Santhosh, C., and P. C. Mishra. "Electronic structures and spectra of 6-mercaptopurine and 6-thioguanine." Spectrochimica Acta Part A: Molecular Spectroscopy 49, no. 7 (1993): 985–93. http://dx.doi.org/10.1016/0584-8539(93)80217-x.

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22

Bronk, J. R., Norma Lister, and M. I. Shaw. "Transport and metabolism of 6-thioguanine and 6-mercaptopurine in mouse small intestine." Clinical Science 74, no. 6 (1988): 629–38. http://dx.doi.org/10.1042/cs0740629.

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1. The transport of 6-thioguanine and 6-mercaptopurine has been studied with isolated jejunal loops of mouse small intestine. H.p.l.c. was used to identify and quantify the thiopurines and their metabolites in the serosal secretions. 2. When the lumen of the intestinal loops contained either 6-thioguanine or 6-mercaptopurine at a concentration of 1 mmol/l, the concentration of unmetabolized drug in the serosal secretions reached a maximum of 0.13 ± 0.02 mmol/l (mean ± sem). 3. Analysis of the serosal secretions from the perfusions with either of the drugs revealed the appearance of an unknown
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23

Jharap, B., NKH de Boer, RM Vos, et al. "Biotransformation of 6-thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6-thioguanine." British Journal of Pharmacology 163, no. 4 (2011): 722–31. http://dx.doi.org/10.1111/j.1476-5381.2011.01265.x.

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24

Kröplin, T., and H. Iven. "Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S -methyltransferase." European Journal of Clinical Pharmacology 56, no. 4 (2000): 343–45. http://dx.doi.org/10.1007/s002280000137.

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25

Ren, Hong Jiang. "Theoretical Investigation on Tautomerization Mechanism of 6-Thioguanine." Advanced Materials Research 690-693 (May 2013): 1418–21. http://dx.doi.org/10.4028/www.scientific.net/amr.690-693.1418.

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The tautomerization reaction mechanisms between three stable 6-thioguanine tautomers were investigated theoretically using B3LYP/6-311+G(d,p) method. The results show that the pathway P(1) is to isomerize from TG(9,10,10,11) to TG(1,9,10,10) and the needed activation Gibbs free energy barrier is 112.7 kJ/mol with the rate constant of 1.12×10-7 s-1. Another two pathways P(2) and P(3) are to isomerize from TG(1,9,10,10) to TG(1,7,10,10) and the activation Gibbs free energy barriers of the rate-determining steps are 227.4 and 281.6 kJ/mol, respectively, with the related rate constants of 8.96×10-
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26

Kim, Jae Ho, Alan A. Alfieri, Sang Hie Kim, and Seung S. Hong. "Radiosensitization of two murine fibrosarcomas with 6-thioguanine." International Journal of Radiation Oncology*Biology*Physics 18, no. 3 (1990): 583–86. http://dx.doi.org/10.1016/0360-3016(90)90064-q.

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27

van den Brand, F. F., Y. S. de Boer, B. J. Verwer, et al. "Evaluation of 6-thioguanine therapy in autoimmune hepatitis." Journal of Hepatology 66, no. 1 (2017): S353—S354. http://dx.doi.org/10.1016/s0168-8278(17)31044-9.

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28

Manikowski, Andrzej, and Jerzy Boryski. "ChemInform Abstract: Transglycosylation Reactions of 6-Thioguanine Acyclonucleosides." ChemInform 33, no. 20 (2010): no. http://dx.doi.org/10.1002/chin.200220184.

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29

Tomsons, U. A., A. A. Avots, and I. A. Kolesnikova. "Optimization of the technology of 6-thioguanine production." Pharmaceutical Chemistry Journal 19, no. 2 (1985): 136–38. http://dx.doi.org/10.1007/bf00771781.

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30

Norman, Amos, J. Cameron Mitchell, and Keisuke S. Iwamoto. "A sensitive assay for 6-thioguanine-resistant lymphocytes." Mutation Research Letters 208, no. 1 (1988): 17–19. http://dx.doi.org/10.1016/0165-7992(88)90014-0.

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31

Lancaster, D. L., N. Patel, L. Lennard, and J. S. Lilleyman. "6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations." British Journal of Clinical Pharmacology 51, no. 6 (2001): 531–39. http://dx.doi.org/10.1046/j.0306-5251.2001.01391.x.

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32

Gilissen, L. P. L., L. J. J. Derijks, A. Driessen, et al. "Toxicity of 6-thioguanine: no hepatotoxicity in a series of IBD patients treated with long-term, low dose 6-thioguanine." Digestive and Liver Disease 39, no. 2 (2007): 156–59. http://dx.doi.org/10.1016/j.dld.2006.10.007.

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33

LaDuke, Kathleen E., Sarah Ehling, John M. Cullen, and Wolfgang Bäumer. "Effects of azathioprine, 6-mercaptopurine, and 6-thioguanine on canine primary hepatocytes." American Journal of Veterinary Research 76, no. 7 (2015): 649–55. http://dx.doi.org/10.2460/ajvr.76.7.649.

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34

Mitra, Raja, and Ashoka G. Samuelson. "Mitigating UVA light induced reactivity of 6-thioguanine through formation of a Ru(ii) half-sandwich complex." RSC Adv. 4, no. 46 (2014): 24304–6. http://dx.doi.org/10.1039/c4ra02960g.

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35

Zackheim, Herschel S., Richard G. Glogau, David A. Fisher, and Howard I. Maibach. "6-Thioguanine treatment of psoriasis: Experience in 81 patients." Journal of the American Academy of Dermatology 30, no. 3 (1994): 452–58. http://dx.doi.org/10.1016/s0190-9622(94)70055-9.

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36

Iven, H., S. Gutsche, and T. Wagner. "Uptake and metabolism of 6-thioguanine in human erythrocytes." Clinical Biochemistry 30, no. 3 (1997): 261. http://dx.doi.org/10.1016/s0009-9120(97)87708-9.

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37

Herrlinger, Klaus R., Wolfgang Kreisel, Peter Deibert, Matthias Schwab, Klaus Fellermann, and Eduard F. Stange. "6-Thioguanine maintains remission in chronic active Crohn's disease." Gastroenterology 124, no. 4 (2003): A519. http://dx.doi.org/10.1016/s0016-5085(03)82624-0.

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38

LESZCZYNSKI, J. "ChemInform Abstract: Tautomers of 6-Thioguanine: Structures and Properties." ChemInform 24, no. 30 (2010): no. http://dx.doi.org/10.1002/chin.199330045.

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39

Arias, Zoraida González, Jesús Luis Muñiz Álvarez, and Juan Miguel López Fonseca. "Surface Layers of 6-Thioguanine on the Mercury Electrode." Journal of Colloid and Interface Science 250, no. 2 (2002): 295–302. http://dx.doi.org/10.1006/jcis.2002.8339.

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40

Gunasekaran, S., S. Kumaresan, R. Arunbalaji, G. Anand, S. Seshadri, and S. Muthu. "Vibrational assignments and electronic structure calculations for 6-thioguanine." Journal of Raman Spectroscopy 40, no. 11 (2009): 1675–81. http://dx.doi.org/10.1002/jrs.2318.

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41

Rulyak, Stephen J., Michael D. Saunders, and Scott D. Lee. "Hepatotoxicity Associated With 6-Thioguanine Therapy for Crohn's Disease." Journal of Clinical Gastroenterology 36, no. 3 (2003): 234–37. http://dx.doi.org/10.1097/00004836-200303000-00010.

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42

Presta, M., M. Belleri, A. Vacca, and D. Ribatti. "Anti-angiogenic activity of the purine analog 6-thioguanine." Leukemia 16, no. 8 (2002): 1490–99. http://dx.doi.org/10.1038/sj.leu.2402646.

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43

Rappaport, Harry P. "The 6-thioguanine/5-methyl-2-pyrimidinone base pair." Nucleic Acids Research 16, no. 15 (1988): 7253–67. http://dx.doi.org/10.1093/nar/16.15.7253.

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44

Schouten, Teunis J., Ronney A. De Abreu, Egbert D. A. M. Schretlen, Marinella B. van Leeuwen, John M. van Baal, and Gérard A. M. de Vaan. "6-Thioguanine: High-dose 2-H infusions in goats." Journal of Cancer Research and Clinical Oncology 110, no. 2 (1985): 115–18. http://dx.doi.org/10.1007/bf00402722.

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45

Eriksson, L., H. Amnéus, and J. Grawé. "Flow sorting and cloning of 6-thioguanine-resistant cells." Mutation Research/Environmental Mutagenesis and Related Subjects 216, no. 1 (1989): 86–88. http://dx.doi.org/10.1016/0165-1161(89)90038-1.

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46

Contreras, J. Guillermo, and Joel B. Alderete. "AM1 studies on the prototropic tautomerism of 6-thioguanine." Journal of Molecular Structure: THEOCHEM 283 (July 1993): 283–87. http://dx.doi.org/10.1016/0166-1280(93)87139-5.

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47

Ahluwalia, Vinod Kumar, Jasjeet Kaur, Balbir Singh Ahuja, and Gurvinder Singh Sodhi. "Thermal studies on organomercury(II) complexes of 6-thioguanine." Thermochimica Acta 176 (March 1991): 321–25. http://dx.doi.org/10.1016/0040-6031(91)80287-s.

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48

Bayoumy, Ahmed B., Chris J. J. Mulder, Aathavan Loganayagam, et al. "Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine." Therapeutic Drug Monitoring 43, no. 5 (2021): 617–23. http://dx.doi.org/10.1097/ftd.0000000000000869.

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49

Volonté, C., A. Rukenstein, D. M. Loeb, and L. A. Greene. "Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase." Journal of Cell Biology 109, no. 5 (1989): 2395–403. http://dx.doi.org/10.1083/jcb.109.5.2395.

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Purine analogues were used in this study to dissect specific steps in the mechanism of action of nerve growth factor (NGF). Protein kinase N (PKN) is an NGF-activated serine protein kinase that is active in the presence of Mn++. The activity of PKN was inhibited in vitro by purine analogues, the most effective of which was 6-thioguanine (apparent Ki = 6 microM). Several different criteria indicated that 6-thioguanine is not a general inhibitor of protein kinases and that it is relatively specific for PKN. For instance, it did not affect protein kinases A or C and was without effect on the over
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50

Petit, Elise, Sophie Langouet, Hanane Akhdar, Christophe Nicolas-Nicolaz, André Guillouzo, and Fabrice Morel. "Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes." Toxicology in Vitro 22, no. 3 (2008): 632–42. http://dx.doi.org/10.1016/j.tiv.2007.12.004.

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