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1

Wang, Jiasheng, Yongxian Hu, Yanlei Zhang, et al. "Quantification of Non-Hodgkin Lymphoma Disease Burden Using FDG PET-CT Helps Predict the Severity of Cytokine Release Syndrome." Blood 132, Supplement 1 (2018): 2997. http://dx.doi.org/10.1182/blood-2018-99-117983.

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Abstract Background: CD19-targeting chimeric antigen receptor (CAR) T-cell therapy has shown great efficacy in patients with refractory/relapsed non-Hodgkin lymphoma (NHL), but was associated with serious adverse effects such as cytokine release syndrome (CRS). It has been speculated that NHL baseline disease burden might affect clinical outcome and CRS, but such assumption has not been explored in detail in previous studies. Metabolic tumor volume (MTV) and total lesion glycolysis (TLG), calculated using FDG PET-CT, are quantitative indicators of baseline tumor burden. Methods: Utilizing FDG
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Adeniji, Folashayo. "Burden of out-of-pocket payments among patients with cardiovascular disease in public and private hospitals in Ibadan, South West, Nigeria: a cross-sectional study." BMJ Open 11, no. 6 (2021): e044044. http://dx.doi.org/10.1136/bmjopen-2020-044044.

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ObjectiveGiven that the mechanism for financial protection is underdeveloped in Nigeria, out-of-pocket (OOP) payment for treating cardiovascular disease could impose substantial financial burden on individuals and their families. This study estimated the burden of OOP expenditures incurred by a cohort of patients with cardiovascular disease (CVD) in Ibadan, Nigeria.Design and settingsThis study used a descriptive cross-sectional study design. A standardised survey questionnaire originally developed by Initiative for Cardiovascular Health Research in Developing Countries was used to electronica
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Wang, Heng Long, Chin Wei Tu, Wei Zhi Wu, et al. "Isolation a Homogalacturonan from the Outer Seed Coat of Shaddock (Citrus grandis Osbeck)." Natural Product Communications 13, no. 6 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300625.

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An acidic mucilage was isolated from the outer-layer seed coat of shaddock (Citrus grandis Osbeck) by water extraction at room temperature, and purified by DE-52 anion-exchange chromatography using 0.26 – 0.37 M NaCl. This purified mucilage was almost entirely composed of galacturonic acid residues. Glycosyl-linkage analysis showed that the backbone was 1→4 linked. Fourier Transform Infrared Spectroscopic analysis and determination of the degree of methylation further revealed that the mucilage was a low-degree (11.94%) esterified homogalacturonan. Size exclusion chromatography showed that the
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Ter-Minassian, Monica, Brinda Somasundaram, and Kala Visvanathan. "Abstract P2-11-12: Benign breast disease and breast malignancy." Cancer Research 82, no. 4_Supplement (2022): P2–11–12—P2–11–12. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-11-12.

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Abstract Introduction: Women with specific types of benign breast disease (BBD) are at higher than average risk for breast cancer. Non-proliferative BBD are at lower risk (1.3-2, compared to women without BBD), proliferative without atypia (1.8), and atypical proliferative such as atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS) are at highest risk (2.5-4). We sought to categorize BBD subtypes for inclusion in a study to evaluate follow up screening and preventative care provided in a real world setting, by leveraging electronic health record and claims databases with refined dia
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Song, Xiaoyue, Qing Qin, Shufu Chang, et al. "Clinical Outcomes of Self-Made Polyurethane-Covered Stent Implantation for the Treatment of Coronary Artery Perforations." Journal of Interventional Cardiology 2021 (May 17, 2021): 1–9. http://dx.doi.org/10.1155/2021/6661763.

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Objectives. The present study aimed to investigate the short- and long-term clinical outcomes of self-made polyurethane-covered stents (PU-CS) in patients for the management of coronary artery perforation (CAP) during percutaneous coronary intervention (PCI). Background. Coronary artery perforation is reckoned as a serious complication in PCI and associated with considerable morbidity and mortality. Covered stents have been used for treating the life-threatening CAP during PCI. But in some catheterization laboratories, no commercial CS is immediately available when there is an urgent need for
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Nur Rosyid, Fahrun, Edi Dharmana, Ari Suwondo, K. Heri Nugroho HS та Sugiarto Sugiarto. "The Effect of Bitter Melon (Momordica charantia L.) Leaves Extract on TNF-α Serum Levels and Diabetic Foot Ulcers Improvement : Randomized Controlled Trial". Biomedical and Pharmacology Journal 11, № 3 (2018): 1413–21. http://dx.doi.org/10.13005/bpj/1505.

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Diabetic foot ulcer (DFU) is among the many complications of diabetes and it takes a very long period of time to heal. It can lead to the amputation of the lower limb, thereby resulting to death or in most cases, a bad quality of life. The aim and objective of this study is to assess the effect of bitter melon leaves extracts on serum TNF-α levels and improvement of diabetic foot ulcers. The study technique used here is the randomized, double-blinded, placebo-controlled trial. Thirty patients suffering from DFU participated in the trial and according to PEDIS scores were divided into two group
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Cullen, Michael J., Jessica Hane, You Zhou, et al. "Perceptions of Justice in Clinical Learning Environments: Development and Validation of an Organizational Justice Measure for Medical Trainees." Academic Medicine 99, no. 12 (2024): 1374–84. https://doi.org/10.1097/acm.0000000000005669.

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Abstract Purpose This study aimed to develop an instrument to measure medical trainees’ perceptions of justice in clinical learning environments. Method Between 2019 and 2023, the authors conducted a multiyear, multi-institutional, multiphase study to develop a 16-item justice measure with 4 dimensions: interpersonal, informational, procedural, and distributive. The authors gathered validity evidence based on test content, internal structure, and relationships with other variables across 3 phases. Phase 1 involved drafting items and gathering evidence that items measured intended dimensions. P
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Gómez-Gallego, Carlos, Himanshu Kumar, Izaskun García-Mantrana, et al. "Breast Milk Polyamines and Microbiota Interactions: Impact of Mode of Delivery and Geographical Location." Annals of Nutrition and Metabolism 70, no. 3 (2017): 184–90. http://dx.doi.org/10.1159/000457134.

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Background/Aims: The aim of the present study was to identify and quantify the polyamine levels in human milk obtained from different countries and through different modes of delivery, and to investigate their association with breast milk microbes. Methods: Mature breast milk samples were obtained from 78 healthy mothers after 1 month of lactation from 4 different geographical locations: Finland, Spain (Europe); South Africa (Africa); and China (Asia). Polyamines were determined using HPLC after dansyl derivatization and milk microbiota was obtained by 16S rRNA gene sequencing. Results: The me
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Bhattarai, Amit Sharma, Gentle Sunder Shrestha, Megha Koirala, Pramesh Sunder Shrestha, and Moda Nath Marhatta. "Evaluation of the Effects of Ultra-Low Dose Naloxone on Brachial Plexus Block with Bupivacaine." Birat Journal of Health Sciences 6, no. 1 (2021): 1373–76. http://dx.doi.org/10.3126/bjhs.v6i1.37640.

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Introduction: Adjuvants are used in conjunction with local anaesthetics for brachial plexus block to quicken onset, prolong duration and augment the quality of anaesthesia.
 Objectives: The study aims to evaluate the effect of adding ultra-low dose naloxone to bupivacaine on the duration of postoperative analgesia.
 Methodology: A prospective, randomized, double-blind study was conducted including forty American Society of Anesthesiologists Physical Status (ASA PS) I and II patients of either sex between 15 and 65 years of age scheduled for upper limb surgery. They were randomized in
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Cherevko, Oleksander, Valeriy Mikhaylov, Andrii Zahorulko, Aleksey Zagorulko, and Irina Gordienko. "Development of a thermal-radiation single-drum roll dryer for concentrated food stuff." Eastern-European Journal of Enterprise Technologies 1, no. 11 (109) (2021): 25–32. http://dx.doi.org/10.15587/1729-4061.2021.224990.

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The design of a thermal-radiation single-drum roll dryer with a combined method of heat supply, application and cutting of the dried layer of raw materials was developed. The dryer allows obtaining a powder fraction of a semi-finished product with a solids content of 3...5 %. Such a design solution will make it possible to obtain a high-quality semi-finished product due to low-temperature drying.
 The effective viscosity of the studied pastes produced by blending apple, sea buckthorn, black chokeberry, beet and pumpkin purees was determined. Adding different percentages of raw materials t
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Khairi, Hilmy, Muhammad Burhannudinnur, and Firman Herdiansyah. "Carbonate Reservoir Characterization Based on Rock Type Analysis in Minahaki Formation and Tomori Formation, "HK" Field, Banggai Basin." IOP Conference Series: Earth and Environmental Science 1104, no. 1 (2022): 012037. http://dx.doi.org/10.1088/1755-1315/1104/1/012037.

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Abstract The research area is located in the Banggai Basin, Central Sulawesi, which part of the Eastern Arm of Sulawesi Island that originated from the collision between Banggai - Sula Microcontinent and West Arm Volcanic Arc from Sulawesi Island. This research has reservoir target in Minahaki Formation and Tomori Formation those are carbonate rocks. The problem limitation of this research is to characterize carbonate reservoir based on the distribution of rock types. The intention of this research is to analyze carbonate reservoirs with petrophysical properties and analyze reservoir character
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12

Cheng, Xin, Gan Zhao, Aihua Dong, et al. "A First-in-Human Trial to Evaluate the Safety and Immunogenicity of a G Protein-Based Recombinant Respiratory Syncytial Virus Vaccine in Healthy Adults 18–45 Years of Age." Vaccines 11, no. 5 (2023): 999. http://dx.doi.org/10.3390/vaccines11050999.

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Background: With the enormous morbidity and mortality caused by respiratory syncytial virus (RSV) infections among infants and the elderly, vaccines against RSV infections are in large market demand. Methods: We conducted a first-in-human (FIH), randomized, double-blind, placebo-controlled dose escalation study to evaluate the safety and immunogenicity response of the rRSV vaccine (BARS13) in healthy adults aged 18–45. A total of 60 eligible participants were randomly assigned to receive one of four dose levels or vaccination regimens of BARS13 or placebo at a 4:1 ratio. Results: The mean age
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Lenhard, R. J., J. C. Parker, and S. Mishra. "Closure to “ On the Correspondence between Brooks‐Corey and van Genuchten Models ” by R. J. Lenhard, J. C. Parker, and S. Mishra (August, 1989, Vol. 115, No. 4)." Journal of Irrigation and Drainage Engineering 117, no. 4 (1991): 610–11. http://dx.doi.org/10.1061/(asce)0733-9437(1991)117:4(610.2).

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Ananda, Ricki, and Muhammad Amin. "ANALISIS PENGARUH PEMASANGAN SEPULUH KAPASITOR KERAMIK 6.8 NF/ 100V TERHADAP PENGIRIMAN DAYA TANPA KABEL DENGAN RANGKAIAN ROYER." JURTEKSI (Jurnal Teknologi dan Sistem Informasi) 5, no. 1 (2019): 71–80. http://dx.doi.org/10.33330/jurteksi.v5i1.301.

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Abstrack: Wireless usage is no longer only able to send data or files, power delivery or power transfer can be applied using wireless networking technology system or also called wireless energy transfer. Research purposes, to make prototype power wireless transfer by using royer oscilator circuit, and turning the load to the maximum with the minimum possible input. Using the 9.8 V input from Trafo 5A and changing the capacitor value of 6.8nf / 100v x10 C on the transmitter (coil transmitter bigger than coil receiver). Installation of each capacitor with a distance of 7 cm, give effect to maxim
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Piltz, John W., Kristy L. Bailes, Suzanne P. Boschma, and Leslie A. Weston. "The Impact of Ensiling at Different Moisture Contents on Germinability and Viability of Selected Weed Species’ Seeds." Agronomy 11, no. 8 (2021): 1639. http://dx.doi.org/10.3390/agronomy11081639.

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Weeds are an increasingly significant issue inhibiting agricultural production worldwide. Forage conservation could form part of an integrated weed management program if ensiling killed weed seeds. In Experiment 1, seeds of five grass (Hordeum spp., Bromus diandrus, Bromus hordeaceum, Lolium rigidum and Vulpia spp.) and two broad-leaved temperate weed species (Echium spp. and Raphanus raphanistrum), that were either untreated, ensiled in pasture (Trifolium subterranean/Lolium rigidum mixture) forage for a minimum of three months, underwent 48 h in sacco digestion in steers or ensiled prior to
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Fernández-Asián, Martínez-González, Torres-Lagares, Serrera-Figallo, and Gutiérrez-Pérez. "External Connection versus Internal Connection in Dental Implantology. A Mechanical in vitro Study." Metals 9, no. 10 (2019): 1106. http://dx.doi.org/10.3390/met9101106.

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(1) Background: In today's dentistry, implantology has become a therapeutic resource of choice in certain clinical situations. The design of implants has evolved in several aspects since their inception. Dental implants were initially designed with an external hex connection, although due to force transmission and security in the adjustment of the prosthesis, later implants featured an internal hex connection. This study aims to analyse the mechanical properties of two types of implants (an internal connection and an external connection) from the same manufacturer and their different prostheti
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Arias-Díaz, Alejandro, Hugo Murcia, Felipe Vallejo-Hincapié, and Károly Németh. "Understanding Geodiversity for Sustainable Development in the Chinchiná River Basin, Caldas, Colombia." Land 12, no. 11 (2023): 2053. http://dx.doi.org/10.3390/land12112053.

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Geodiversity, comprising both endogenous and exogenous geological processes, plays a crucial role in shaping the structure and functionality of natural systems, alongside its substantial impact on human well-being. However, the often-overlooked interconnection between geodiversity components limits our comprehension of geosystems. In the Chinchiná River Basin (CRB) in Colombia, located in the northern Andes in South America, we established criteria to differentiate geodiversity classes, calculated indices to understand the distribution of geological elements, and discussed systemic relationshi
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Usifo, Abel Giwa, and Adewole John Adeola. "Delineation of Groundwater at Iseyin, South Western Nigeria." Current Journal of Applied Science and Technology 43, no. 6 (2024): 78–90. http://dx.doi.org/10.9734/cjast/2024/v43i64388.

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Aims: This research was carried out to determine: the variation in resistivity of the different soil profiles in the area, the depth and thickness of the weathered basement, the depth and thickness of the aquifer, the depth to basement, and to establish areas suitable for borehole development. Materials and Methods: Vertical Electrical Sounding (VES) was carried out using Schlumberger electrode array. A pair of potential and current electrodes was arranged in such a way that the potential electrodes were positioned in between the current electrodes and the positioning of the electrodes was set
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Oleksander, Cherevko, Mikhaylov Valeriy, Zahorulko Andrii, Zagorulko Aleksey, and Gordienko Irina. "Development of a thermal-radiation single-drum roll dryer for concentrated food stuff." Eastern-European Journal of Enterprise Technologies 1, no. 11(109) (2021): 25–32. https://doi.org/10.15587/1729-4061.2021.224990.

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The design of a thermal-radiation single-drum roll dryer with a combined method of heat supply, application and cutting of the dried layer of raw materials was developed. The dryer allows obtaining a powder fraction of a semi-finished product with a solids content of 3...5 %. Such a design solution will make it possible to obtain a high-quality semi-finished product due to low-temperature drying. The effective viscosity of the studied pastes produced by blending apple, sea buckthorn, black chokeberry, beet and pumpkin purees was determined. Adding different percentages of raw materials to
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20

Glazkova, O. L., N. M. Podzolkova, S. V. Shmeleva, and N. V. Baymeeva. "Oxidative stress parameters and pro-inflammatory status of patients with menstrual disorders against obesity treatment." Voprosy ginekologii, akušerstva i perinatologii 20, no. 4 (2021): 149–54. http://dx.doi.org/10.20953/1726-1678-2021-4-149-154.

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Objective. To study the effect of cyclical vitamin therapy on the parameters of oxidative stress and pro-inflammatory status of patients with menstrual disorders against the background of obesity treatment. Patients and methods. The study included 49 women aged 20 to 35 years (29.4 (26.5; 33.2) years) with obesity and various menstrual disorders. Twenty-six (53.06%) patients had polycystic ovary syndrome (PCOS). To treat obesity, 26 patients followed a diet and received Orlistat 120 mg three times a day. Twenty-three women received similar treatment and additionally took micronutrient suppleme
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Aktayeva, Saniya, and Bekbolat Khassenov. "High keratinase and other types of hydrolase activity of the new strain of Bacillus paralicheniformis." PLOS ONE 19, no. 10 (2024): e0312679. http://dx.doi.org/10.1371/journal.pone.0312679.

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Keratinases, a subclass of proteases, are used to degrade keratin thereby forming peptones and free amino acids. Bacillus paralicheniformis strain T7 was isolated from soil and exhibited high keratinase, protease, collagenase, amylase, xylanase, lipase, and phosphatase activities. Keratinases of the strain showed maximum activity at 70°C and pH 9.0 as well as high thermal stability. A mass-spectrometric analysis identified seven peptidases with molecular masses of 26.8–154.8 kDa in the secretory proteome. These peptidases are members of S8 and S41 serine peptidase families and of M14, M42, and
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Syed, Moniruzzaman, Teresa Jackson, Carlissa Farmer, Madihazaman Syeda, and Farhan Azim. "Sol-Gel Derived CdO:Al Thin Films on Various Substrates: A Comprehensive Study on Structural, Morphological, Optical, and Electrical Properties." Journal of Materials Science Research 14, no. 1 (2025): 22. https://doi.org/10.5539/jmsr.v14n1p22.

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Aluminum-doped cadmium oxide (CdO:Al) thin films were deposited onto glass and silicon substrates using the sol–gel spin-coating method, with deposition time varied as a key parameter. Cadmium acetate dihydrate served as the precursor material, while aluminum nitrate was used as the aluminum dopant source. The structural, optical, and electrical properties of the CdO:Al films were characterized using X-ray diffraction (XRD), Raman spectroscopy, Ellipsometry, Surface roughness analysis, Fourier-transform infrared spectroscopy (FTIR), Electrical resistivity, and UV-Vis spectroscopy. XR
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Harms, Wiebke, Viktoria Mihajlov, Marco Wendorff, and Caroline Röhr. "CaAgxZn1– x: Zwischen CrB- und FeB-Strukturtyp – Eine Studie zu elektronischen Einflüssen auf die Stapelung von Zick-Zack-Ketten in polaren Erdalkalimetall-Monometalliden / CaAgxZn1−x: Between CrB and FeB Structure Type – A Study on Electronic Factors Influencing the Stacking of Zig-zag Chains in Polar Alkaline Earth Monometallides." Zeitschrift für Naturforschung B 64, no. 10 (2009): 1127–42. http://dx.doi.org/10.1515/znb-2009-1005.

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Depending on both electronic (valence electron numbers) and geometric (atom size ratios) characteristics of the contributing elements, the 1 : 1 compounds AIIM of the heavier alkaline earth elements A and electron-rich transition metals M form the well known CrB or FeB structure types. Both structure types exhibit M zig-zag chains, which are stacked in different orientations. In systematic studies of the pseudo-binary section CaAgxZn1−x four new ternary phases with different stacking variants between the CrB (cubic stacking, c) and the FeB (hexagonal stacking, h2) structure type have been prep
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24

Soler, Fernando, Laura Galvez, Sarah Rubio, Izadora B. Batista Kuneff, Pete Wilcock, and Eric van Heugten. "PSIII-13 Evaluation of reduced dietary crude protein and amino acid concentrations in diets for nursery pigs." Journal of Animal Science 103, Supplement_1 (2025): 299–300. https://doi.org/10.1093/jas/skaf102.333.

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Abstract Reducing crude protein (CP) in diets for nursery pigs exposed to enteric challenges has been suggested to decrease pathogenic bacterial proliferation, diarrhea, morbidity, and mortality. This study evaluated the effects of feeding reduced CP by lowering amino acid (AA) concentrations in the post-weaning diet on growth performance, feed efficiency, and diarrhea incidence in nursery pigs and further evaluated whether increasing amino acid concentrations in the subsequent diet could recover potential lost performance through compensatory growth. Weaned pigs (n=180; 21-day old; BW=6.63±1.
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Losano, J., J. Padín, I. Méndez-López, et al. "143 Stimulated glycolysis is able to maintain ATP levels and motility of bull spermatozoa submitted to mitochondrial depolarisation." Reproduction, Fertility and Development 32, no. 2 (2020): 198. http://dx.doi.org/10.1071/rdv32n2ab143.

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Studies have reported the importance of mitochondria in sperm metabolism. However, for some species, glycolysis appears to be as essential as oxidative phosphorylation in sperm physiology. On the other hand, these mechanisms have not been fully elucidated for bovine spermatozoa. Therefore, the aim of this study was to evaluate the role of mitochondria and glycolysis in ATP synthesis and sperm kinetics of bovine spermatozoa. For this purpose, sperm from seven bovine epididymides (n=7) was collected and diluted to a concentration of 100×106 spermatozoamL−1 in Tyrode's albumin lactate pyruvate me
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Senapedis, William, Ryan George, Dilara McCauley, et al. "Novel Selective Orally Bioavailable Small Molecule PAK4 Allosteric Modulators (PAMs) Display Anti-Tumor Activity in Vitro and in Vivo in Hematological Malignancies." Blood 124, no. 21 (2014): 2208. http://dx.doi.org/10.1182/blood.v124.21.2208.2208.

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Abstract Introduction: Many hematological cancers have been successfully treated through identification of specialized targets in each specific tumor subtype (e.g. BTK inhibition in NHL or proteasome inhibition in multiple myeloma). The p21-Activated Kinase 4 (PAK4) is critical to cellular signaling and may represent a new target for therapy in many hematologic malignancies. PAK4 is a member of the PAK family of proteins that regulate cell survival, cell division and apoptosis. The six members of the PAK family are divided into two groups; Group I (PAK1, 2, 3) and Group II (PAK4, 5, 6), based
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Benini, Anna, Rossella Gottardo, Cristiano Chiamulera, Anna Bertoldi, Lorenzo Zamboni, and Fabio Lugoboni. "Continuous Infusion of Flumazenil in the Management of Benzodiazepines Detoxification." Frontiers in Psychiatry 12 (March 18, 2021). http://dx.doi.org/10.3389/fpsyt.2021.646038.

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An effective approach in the treatment of benzodiazepine (BZD) overdosing and detoxification is flumazenil (FLU). Studies in chronic users who discontinued BZD in a clinical setting suggested that multiple slow bolus infusions of FLU reduce BZD withdrawal symptoms. The aim of this study was to confirm FLU efficacy for reducing BZD withdrawal syndrome by means of continuous elastomeric infusion, correlated to drugs plasma level and patients' compliance.Methods: Seven-day FLU 1 mg/day subcutaneously injected through an elastomeric pump and BZDs lormetazepam, clonazepam, and lorazepam were assess
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Fels‐Palesandro, Hannah, Sophie Heuer, Berin Boztepe, et al. "Assessment of Tumor Cell Invasion and Radiotherapy Response in Experimental Glioma by Magnetic Resonance Elastography." Journal of Magnetic Resonance Imaging, August 23, 2024. http://dx.doi.org/10.1002/jmri.29567.

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BackgroundGliomas are highly invasive brain neoplasms. MRI is the most important tool to diagnose and monitor glioma but has shortcomings. In particular, the assessment of tumor cell invasion is insufficient. This is a clinical dilemma, as recurrence can arise from MRI‐occult glioma cell invasion.HypothesisTumor cell invasion, tumor growth and radiotherapy alter the brain parenchymal microstructure and thus are assessable by diffusion tensor imaging (DTI) and MR elastography (MRE).Study TypeExperimental, animal model.Animal ModelTwenty‐three male NMRI nude mice orthotopically implanted with S2
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Abdelhady, Salem, Hossam Shokri, Mai Fathy, and mona Mokhtar wahid el din. "Evaluation of the direct costs of epilepsy in a sample of Egyptian patients following up in Ain Shams University Hospital." Egyptian Journal of Neurology, Psychiatry and Neurosurgery 56, no. 1 (2020). http://dx.doi.org/10.1186/s41983-020-00247-3.

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Abstract Background Epilepsy is a chronic disorder of the brain, and it is considered as the 4th common neurological disorder. Epilepsy is associated with an economic burden by imposing a significant burden on both the individuals who have the condition and on those around them, as well as for the society. Objective Our objective is to study and evaluate the direct costs associated with the medical management of epilepsy, one of the most common neurological conditions. Methods Observational, cross-sectional 4-month study started in December 2018 till April 2019 in patients between 2 and 60 yea
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