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Journal articles on the topic '620.001 51'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Reynolds, A. M., and K. M. Mullins. "0407 Sleep, Stress, Cardiovascular, and Psychological Health in College Students." Sleep 43, Supplement_1 (2020): A156. http://dx.doi.org/10.1093/sleep/zsaa056.404.

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Abstract Introduction Epidemiological studies have long established that sleep factors, stress, and cardiovascular health are related. College students often struggle with the demands of college life, which leads to increased stress, symptoms of depression and anxiety, and poor sleep. The focus of the current study was to examine habitual sleep habits in college students, in association with psychological factors and physiological factors. Methods Participants included 51 undergraduate students (18 men, average age M=20.25 years, SD=1.78) who wore wrist actigraphs to measure their typical slee

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Micol, Jean-Baptiste, Nicolas Boissel, Aline Renneville, et al. "The Role of Cytogenetic Abnormalities in Acute Myeloid Leukemia with NPM1 mutations and No FLT3 Internal Tandem Duplication." Blood 114, no. 22 (2009): 1594. http://dx.doi.org/10.1182/blood.v114.22.1594.1594.

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Abstract Abstract 1594 Poster Board I-620 Background Nucleophosmin (NPM1) gene mutations are observed in almost one-third of adult acute myeloid leukemia (AML). If the favorable genotype defined by the presence of NPM1 mutations without fms-like tyrosine kinase 3 (FLT3) internal tandem duplication (ITD) is known to be associated with favorable outcome in patients with cytogenetically normal (CN) acute myeloid leukemia (AML), impact of these molecular abnormalities are still debated in those with cytogenetically abnormal (CA) AML. Patients and Methods We analyzed the role of these factors in ne

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Keating, Michael J., Susan O’Brien, Maher Albitar, Susan Lerner, William Wierda, and Hagop Kantarjian. "Extended Follow-Up of a Chemo-Immunotherapy Regimen FCR (Fludarabine, F; Cyclophosphamide, C; and Rituximab, R) as Initial Therapy for Chronic Lymphocytic Leukemia (CLL)." Blood 106, no. 11 (2005): 2118. http://dx.doi.org/10.1182/blood.v106.11.2118.2118.

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Abstract Combination regimens are increasingly being used in CLL. The addition of R to F±C has increased the complete response (CR) rate in previously untreated patients (pts) with CLL. FCR was given to 300 previously untreated pts with CLL; 70.3% male, 33% Rai stage III-IV, with median value and ranges for age − 57 years (17–86), hemoglobin − 12.5G% (6.1–18.7), white cell count − 76 x 103/μl (2.1–620), platelets − 154 x 103/μl (8–406). 51% had splenomegaly. All pts fulfilled the NCIWG indications for therapy. 72% achieved CR, 10% nodular partial remission (NPR), and 12% PR. The pretreatment c

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Coustan-Smith, Elaine, Jose Sancho, Frederick G. Behm, et al. "Prognostic importance of measuring early clearance of leukemic cells by flow cytometry in childhood acute lymphoblastic leukemia." Blood 100, no. 1 (2002): 52–58. http://dx.doi.org/10.1182/blood-2002-01-0006.

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Abstract Early clearance of leukemic cells is a favorable prognostic indicator in childhood acute lymphoblastic leukemia (ALL). However, identification of residual leukemic cells by their morphologic features is subjective and lacks sensitivity. To improve estimates of leukemia clearance, we applied flow cytometric techniques capable of detecting 1 leukemic cell in 10 000 or more normal cells and prospectively measured residual leukemia in bone marrow samples collected on day 19 of remission-induction chemotherapy from 248 children with newly diagnosed ALL. In 134 samples (54.0%), we identifie

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Fu, Guodong, Ronald S. Chazen, Christina MacMillan, and Ian J. Witterick. "Discriminating Interpatient Variabilities of RAS Gene Variants for Precision Detection of Thyroid Cancer." JAMA Network Open 7, no. 5 (2024): e2411919. http://dx.doi.org/10.1001/jamanetworkopen.2024.11919.

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ImportanceInterpatient variabilities in genomic variants may reflect differences in tumor statuses among individuals.ObjectivesTo delineate interpatient variabilities in RAS variants in thyroid tumors based on the fifth World Health Organization classification of thyroid neoplasms and assess their diagnostic significance in cancer detection among patients with thyroid nodules.Design, Setting, and ParticipantsThis prospective diagnostic study analyzed surgically resected thyroid tumors obtained from February 2016 to April 2022 and residual thyroid fine-needle aspiration (FNA) biopsies obtained

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Chow, Ryan Dz-Wei, Jessica B. Long, Sirad Hassan, et al. "Evolution of systemic therapy from 2015 to 2019 for older patients in the United States with metastatic renal cell carcinoma." Journal of Clinical Oncology 41, no. 6_suppl (2023): 610. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.610.

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610 Background: Immune checkpoint inhibitors (IOs) and oral anti-cancer agents (OAAs) have demonstrated survival improvements in randomized trials of patients with metastatic renal cell carcinoma (mRCC). IOs were approved as second-line mRCC therapy in 2015 (nivolumab), followed by first-line approval in 2018 (ipilimumab/nivolumab). Real-world changes in overall treatment rates and IO usage have not been examined in patients over 65, who are often underrepresented in trials. Disparities in mRCC outcomes have persisted in the era of these novel therapies, raising the question of whether receipt

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Fonseca, A. J. M., A. A. Dias-da-Silva, and A. L. G. Lourenço. "Effects of maize and citrus-pulp supplementation of urea-treated wheat straw on intake and productivity in female lambs." Animal Science 73, no. 1 (2001): 123–36. http://dx.doi.org/10.1017/s1357729800058124.

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AbstractTwo experiments with lambs given food indoors and individually penned were designed to study the effects of different levels of ground maize and citrus pulp as supplements of a diet based on urea-treated straw (5 kg urea per 100 kg straw) offered ad libitum over a period of 16 weeks (experiment 1) or 10 weeks (experiment 2). The voluntary intake, live-weight gain (LWG), organic matter digestibility (OMD), urinary allantoin-nitrogen (UAN) excretion and acetate clearance rate were measured. The lambs were blocked on weight and randomly assigned to the treatments described below. Ruminal

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Luna, Marcos. "Effect of reproductive indices and bovine somatotropin on milk yield in Holstein cows experiencing climatic sub-fertility." Mljekarstvo 73, no. 3 (2023): 155–63. http://dx.doi.org/10.15567/mljekarstvo.2023.0302.

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This study aimed at determining the association between reproductive indexes and the total milk yield in non-planed lactations ≥600 days in sub-fertile Holstein cows treated or not with recombinant bovine somatotropin (rbST) and experienced prolonged hyperthermia. A total of 1141 cows with a single lactation were enrolled in the study: 622 were not treated with rbST (control) and 519 were treated with rbST (500 mg every 14 days throughout lactation). Across parities, control cows with >480 days open, produced 5642 kg more milk (p<0.01) than cows with <380 days open. rbST-treated cows

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Soverini, Simona, Sabrina Colarossi, Alessandra Gnani, et al. "Frequency, Distribution and Prognostic Value of ABL Kinase Domain (KD) Mutations in Different Subsets of Philadelphia-Positive (Ph+) Patients (Pts) Resistant to Imatinib (IM) by the Gimema Working Party on CML." Blood 106, no. 11 (2005): 435. http://dx.doi.org/10.1182/blood.v106.11.435.435.

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Abstract Using denaturing-high performance liquid chromatography and sequencing, we screened for ABL KD mutations 319 IM-resistant Ph+ pts. Median time between diagnosis and IM start at 400–600 mg/d was 40 (0–160) months. Median duration of IM was 27 (9–62) months. Evaluable pts were 256/319 (80%). At the time of analysis, 178/256 (70%) pts were in chronic phase (CP)(36 previously untreated, 142 post-IFN failure), 16 (6%) pts were in accelerated phase (AP), 26 (10%) pts were in myeloid blast crisis (myBC), 36 (14%) were in lymphoid blast crisis (lyBC) or had Ph+ acute lymphoblastic leukemia (A

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Ginn, Brian K., Brian F. Cumming, and John P. Smol. "Assessing pH changes since pre-industrial times in 51 low-alkalinity lakes in Nova Scotia, Canada." Canadian Journal of Fisheries and Aquatic Sciences 64, no. 8 (2007): 1043–54. http://dx.doi.org/10.1139/f07-078.

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Diatom-based paleolimnological techniques were used to reconstruct lake acidification trends in 51 low-alkalinity Nova Scotia lakes that spanned gradients of dissolved organic carbon (DOC) concentrations and sulphate deposition. Pre-industrial, diatom-inferred pH values of these lakes were <6.8, with 31 lakes having pre-industrial pH < 6.0 and two lakes having pH < 5.5. Lakes in Kejimkujik National Park documented the greatest pH decline (–0.4 pH unit (±0.2)) since the 19th century, whereas those in northern parts of the province (e.g., Cape Breton Highlands National Park) experienced

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Abram, Simon G. F., Andrew Judge, David J. Beard, Hannah A. Wilson, and Andrew J. Price. "Temporal trends and regional variation in the rate of arthroscopic knee surgery in England: analysis of over 1.7 million procedures between 1997 and 2017. Has practice changed in response to new evidence?" British Journal of Sports Medicine 53, no. 24 (2018): 1533–38. http://dx.doi.org/10.1136/bjsports-2018-099414.

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ObjectivesWe investigated trends and regional variation in the rate of arthroscopic knee surgery performed in England from 1997–1998 to 2016–2017.DesignCross-sectional study of the national hospital episode statistics (HES) for England.MethodsAll hospital episodes for patients undergoing a knee arthroscopy between 1 April 1997 and 31 March 2017 were extracted from HES by procedure code. Age and sex-standardised rates of surgery were calculated using Office for National Statistic population data as the denominator. Trends in the rate of surgery were analysed by procedure both nationally and by

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Cheng, Phoebe Tsz Man, Diego Villa, Alina S. Gerrie, et al. "Outcome of elderly patients with classical Hodgkin lymphoma (HL) in British Columbia." Journal of Clinical Oncology 38, no. 15_suppl (2020): 8031. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.8031.

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8031 Background: Outcomes in elderly patients (pts) with Hodgkin lymphoma (HL) have traditionally been poor. We evaluated the survival of elderly pts (>60 years [y]) with classical HL in British Columbia (BC). Methods: All pts aged >60 y newly diagnosed with classical HL from 1961 to 2019 were identified in the BC Cancer Lymphoid Cancer Database. Limited stage was defined as non-bulky (<10 cm) stage 1A/IB or 2A (before 2000 1B = advanced stage), with the remainder considered advanced stage. Results: Following exclusions (HIV positive n=4, incomplete data n=21, prior or concurrent othe

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Spiegl, Ulrich J. A., Philipp Schenk, Klaus John Schnake, et al. "Treatment and Outcome of Osteoporotic Thoracolumbar Vertebral Body Fractures With Deformation of Both Endplates With or Without Posterior Wall Involvement (OF 4): Short-Term Results from the Prospective EOFTT Multicenter Study." Global Spine Journal 13, no. 1_suppl (2023): 36S—43S. http://dx.doi.org/10.1177/21925682221140831.

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Study Design Multicenter prospective cohort study Objective To analyse therapeutical strategies applied to osteoporotic thoracolumbar OF 4 injuries, to assess related complications and clinical outcome. Methods A multicenter prospective cohort study (EOFTT) including 518 consecutive patients who were treated for an Osteoporotic vertebral compression fracture (OVCF). For the present study, only patients with OF 4 fractures were analysed. Outcome parameters were complications, Visual Analogue Scale, Oswestry Disability Questionnaire, Timed Up & Go test, EQ-5D 5L, and Barthel Index after a mi

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Choi, Yoonseok, Hansol Kim, and Christiane Hoppmann. "AGE-RELATED DIFFERENCES IN EVERYDAY SOLITUDE SEEKING WHEN TIME WITH OTHERS FEELS LESS DESIRABLE." Innovation in Aging 8, Supplement_1 (2024): 1089. https://doi.org/10.1093/geroni/igae098.3498.

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Abstract People spend a significant amount of time by themselves. This project seeks to investigate one potential motive underlying solitude seeking in daily life, namely, to disengage from undesirable social interactions. Social relationships and interactions often involve obligations to others, particularly so in collectivistic cultures; meeting obligations can be taxing when social demands exceed one’s capacity. Seeking solitude may be a way to reduce obligation-related social strains. Additionally, there may be age-related differences in motive strength considering age-related differences

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Abu Zaid, Mohammad, Paul C. Dinh, Patrick O. Monahan, et al. "Adverse Health Outcomes in Relationship to Hypogonadism After Chemotherapy: A Multicenter Study of Testicular Cancer Survivors." Journal of the National Comprehensive Cancer Network 17, no. 5 (2019): 459–68. http://dx.doi.org/10.6004/jnccn.2018.7109.

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Background: This study examined the prevalence of hypogonadism, its clinical and genetic risk factors, and its relationship to adverse health outcomes (AHOs) in North American testicular cancer survivors (TCS) after modern platinum-based chemotherapy. Patients and Methods: Eligible TCS were <55 years of age at diagnosis and treated with first-line platinum-based chemotherapy. Participants underwent physical examinations and completed questionnaires regarding 15 AHOs and health behaviors. Hypogonadism was defined as serum testosterone levels ≤3.0 ng/mL or use of testosterone replacement ther

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Manian, Farrin A., and John J. Ponzillo. "Compliance With Routine Use of Gowns by Healthcare Workers (HCWs) and Non-HCW Visitors on Entry Into the Rooms of Patients Under Contact Precautions." Infection Control & Hospital Epidemiology 28, no. 3 (2007): 337–40. http://dx.doi.org/10.1086/510811.

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Background.Modified contact precautions (MCP), defined as routine donning of isolation gowns (along with routine gloving) on entry into the rooms of patients under contact precautions, regardless of the likelihood of direct exposure to the patient or their immediate environment, were instituted at our medical center to reduce nosocomial transmission of common hospital pathogens.Objectives.To study compliance with MCP policy regarding routine gowning in intensive care units (ICUs) and general wards and to determine the relationship between gown and glove use in the care of patients under MCP in

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Kuguyo, Oppah, Racheal S. Dube Mandishora, Nicholas Ekow Thomford, et al. "High-risk HPV genotypes in Zimbabwean women with cervical cancer: Comparative analyses between HIV-negative and HIV-positive women." PLOS ONE 16, no. 9 (2021): e0257324. http://dx.doi.org/10.1371/journal.pone.0257324.

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Background High-risk human papillomavirus HPV (HR-HPV) modifies cervical cancer risk in people living with HIV, yet African populations are under-represented. We aimed to compare the frequency, multiplicity and consanguinity of HR-HPVs in HIV-negative and HIV-positive Zimbabwean women. Methods This was a cross-sectional study consisting of women with histologically confirmed cervical cancer attending Parirenyatwa Group of Hospitals in Harare, Zimbabwe. Information on HIV status was also collected for comparative analysis. Genomic DNA was extracted from 258 formalin fixed paraffin embedded tumo

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Guglielmelli, Paola, Giada Rotunno, Annalisa Pacilli, et al. "Prognostic Impact of Bone Marrow Fibrosis in Primary Myelofibrosis: A Study of Agimm Group on 540 Patients." Blood 126, no. 23 (2015): 351. http://dx.doi.org/10.1182/blood.v126.23.351.351.

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Abstract Background. The prognostic significance of bone marrow (BM) fibrosis grade in pts with primary myelofibrosis (PMF) is debated. A fibrosis grade greater than 1 was associated with a 2-fold higher risk of death compared with pts with early/prefibrotic MF (grade 0) [Thiele J, Ann Hematol 2006]. Recent data suggest that more accurate prediction of survival is achieved when fibrosis grade is added to IPSS [Verner C, Blood 2008; Giannelli U, Mod Pathol 2012]. Aim. To analyze the prognostic impact of fibrosis in diagnostic BM samples of 540 WHO-2008 diagnosed PMF pts with extensive clinical

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Hosseinzadeh, Shayan, Ata M. Kiapour, Daniel A. Maranho, et al. "The metaphyseal fossa surrounding the epiphyseal tubercle is larger in hips with moderate and severe slipped capital femoral epiphysis than normal hips." Journal of Children's Orthopaedics 14, no. 3 (2020): 184–89. http://dx.doi.org/10.1302/1863-2548.14.200010.

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Purpose To compare the 3D morphology of the metaphyseal fossa among mild, moderate and severe stable slipped capital femoral epiphysis (SCFE) and normal hips. Methods We identified pelvic CT of 51 patients (55% male; mean 12.7 years (sd 1.9; 8-15)) with stable SCFE. In all, 16 of 51 hips (31%) had mild, 14 (27%) moderate and 21 (41%) severe SCFE. A total of 80 patients (50% male; mean age 11.5 years (sd 2.3; 8 to 15)) with normal hips who underwent pelvic CT due to abdominal pain made up the control cohort. CT scans were segmented, and the femur was reformatted using 3D software. We measured t

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Brodsky, Robert A., Neal S. Young, Elisabetta Antonioli, et al. "Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria." Blood 111, no. 4 (2008): 1840–47. http://dx.doi.org/10.1182/blood-2007-06-094136.

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The terminal complement inhibitor eculizumab was recently shown to be effective and well tolerated in patients with paroxysmal nocturnal hemoglobinuria (PNH). Here, we extended these observations with results from an open-label, non–placebo-controlled, 52-week, phase 3 clinical safety and efficacy study evaluating eculizumab in a broader PNH patient population. Eculizumab was administered by intravenous infusion at 600 mg every 7 ± 2 days for 4 weeks; 900 mg 7 ± 2 days later; followed by 900 mg every 14 ± 2 days for a total treatment period of 52 weeks. Ninety-seven patients at 33 internationa

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Schneider, François, Gérard Lefebvre, Michèle Ribolzi-Chery, Jean-Michel Bertin, and Robert Gay. "Purification et quelques propriétés de l'AMPc phosphodiestérase d'Arthrobacter crystallopoietes." Biochemistry and Cell Biology 66, no. 5 (1988): 454–59. http://dx.doi.org/10.1139/o88-055.

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cAMP phosphodiesterase was purified 8250-fold from extracts of Arthrobacter crystallopoietes, primarily by hydrophobic chromatography. The molecular weight of this enzyme was estimated as 51 000 by gel filtration and density-gradient centrifugation. The results suggest that the enzyme consists of two subunits with a molecular weight of 25 600. Properties of this enzyme are reported, including its negative cooperativity. This phosphodiesterase specifically catalyzes the hydrolysis of 3′,5′-cyclic nucleotides. Divalent ions either have no effect on activity or are weak inhibitors. Photooxidation

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Stem, Maxwell S., Danny A. Mammo, Yoshihiro Yonekawa, Bozho Todorich, Benjamin J. Thomas, and George A. Williams. "Centenarians With Age-Related Macular Degeneration." Journal of VitreoRetinal Diseases 1, no. 5 (2017): 310–13. http://dx.doi.org/10.1177/2474126417726858.

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Purpose: To report the clinical findings in patients ≥100 years old who have age-related macular degeneration (AMD). Methods: We identified patients ≥100 years old who had non-neovascular AMD, neovascular AMD or both. Results: Sixty-two patients were included. The mean (SD) age was 102 (1.4) years (range, 100-106 years). Most patients were white (n = 51, 82%), women (n = 51, 82%), and had at least 1 eye affected by neovascular AMD (n = 55, 89%). The mean Snellen visual acuity (VA) among eyes with neovascular AMD was worse than that for eyes with non-neovascular AMD (20/600 [range, 20/40-hand m

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Elliott, Cara G., Ally Murji, John Matelski, Adebanke Bianca Adekola, Jessica Chrzanowski, and Lindsay Shirreff. "Unexpected malignancy at the time of hysterectomy performed for a benign indication: A retrospective review." PLOS ONE 17, no. 4 (2022): e0266338. http://dx.doi.org/10.1371/journal.pone.0266338.

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Objective To determine the proportion of patients undergoing hysterectomy for a benign indication who have unexpected malignancy (UM) on postoperative pathology and characterize the nature of UMs. Methods This was a multi-center, retrospective study of patients undergoing hysterectomy for a benign indication from July 2016 to December 2019 at 7 Ontario, Canada hospitals (4 academic, 3 community). Hysterectomies for invasive placentation, malignant, and premalignant indications were excluded. Primary outcome was rate of unexpected malignancy as defined by the number of patients with malignancy

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Sullivan, Thomas P., John A. Krebs, and Paul K. Diggle. "Prediction of stand susceptibility to feeding damage by red squirrels in young lodgepole pine." Canadian Journal of Forest Research 24, no. 1 (1994): 14–20. http://dx.doi.org/10.1139/x94-003.

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This paper provides a forecast model to predict when and where significant feeding damage by red squirrels (Tamiasciurushudsonicus Erxleben) will occur in managed stands of lodgepole pine (Pinuscontorta Dougl. var. latifolia Engelm.). Information from 51 managed stands (average DBH > 6.0 cm) in the interior of British Columbia and from past squirrel population studies was used to formulate the model. Incidence of damage was significantly greater in stands originating from wildfire than from harvesting. Stands within the Montane Spruce biogeoclimatic zone had the highest levels of damage of

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Dolbachev, A. P., N. A. Belov, and T. K. Akopyan. "Experimental study of single tracks obtained from a mixture of Ti and Al powders with varying selective laser melting parameters." Izvestiya Vuzov. Tsvetnaya Metallurgiya (Universities' Proceedings Non-Ferrous Metallurgy), no. 4 (August 13, 2021): 51–58. http://dx.doi.org/10.17073/0021-3438-2021-4-51-58.

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The paper studies the effect of the laser scanning speed (vs) on the morphology of single tracks obtained from a mixture of Ti and Al powders in a stoichiometric ratio of 1 : 1 in longitudinal and cross sections. Droplets of splashed liquid were found on the outer surface of the track obtained at vs = 300 mm/s. Their appearance is resulted most likely from the release of gas bubbles formed due to the evaporation of aluminum having a lower melting point. A distortion of a single track along its length was observed with an increase in vs values up to 600 mm/s. It was found that tracks loose stab

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Wang, Eunice S., Pau Montesinos, Ghayas C. Issa, et al. "Ziftomenib in relapsed/refractory (R/R) NPM1 -mutant acute myeloid leukemia (AML): Phase 1b/2 clinical activity and safety results from the pivotal KOMET-001 study." Journal of Clinical Oncology 43, no. 16_suppl (2025): 6506. https://doi.org/10.1200/jco.2025.43.16_suppl.6506.

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6506 Background: NPM1 -m drives leukemogenesis in ~30% of AML. Despite current risk stratification, nearly half will have R/R disease within a year, after which outcomes are poor with <10% complete response following chemotherapy. Ziftomenib – a potent, highly selective, oral, investigational menin inhibitor – has shown clinical activity as monotherapy and in combination for adults with R/R NPM1 -m and KMT2A -r AML, with 600 mg once-daily (QD) as the recommended phase 2 monotherapy dose for NPM1 -m. Here we present the primary analysis for NPM1 -m patients (pts) treated with ziftomenib 600

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Nair, S., K. M. Tshabalala, and F. Abdullah. "Factors associated with advanced HIV in the Tshwane District drainage area: A protocol for a cross-sectional analytical study." Southern African Journal of Public Health 7, no. 3 (2024): e2564. https://doi.org/10.7196/shs.2024.v7.i3.2564.

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Background. HIV continues to be a global pandemic. Despite significant achievements in reaching the global 95-95-95 targets, advanced HIV disease (AHD) continues to contribute to substantial morbidity and mortality, with 600 000 deaths worldwide in 2022 including 51 000 in South Africa (SA). The patient demographic has shifted from antiretroviral therapy (ART)-naïve individuals to those facing treatment interruptions or non-adherence. Objective. To explore the factors associated with AHD in patients within the Tshwane District drainage area, SA, where high treatment coverage has not fully cur

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Kara, K. "Milk urea nitrogen and milk fatty acid compositions in dairy cows with subacute ruminal acidosis." Veterinární Medicína 65, No. 8 (2020): 336–45. http://dx.doi.org/10.17221/51/2020-vetmed.

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The present study was aimed at comparing the milk urea nitrogen (MUN) and milk fatty acid (MFA) compositions in Holstein cows with subacute ruminal acidosis (SARA) to those values of Holstein cows that did not have SARA. Also, the correlations among rumen pH value and the compositions of MUN and MFA in milk were determined. Dairy cows (n = 16) with subacute ruminal acidosis (SARA) (pH value 5.60 ± 0.02) and control dairy cows (n = 16) (control) (pH value 6.20 ± 0.04) were studied. The MUN concentrations (578 µg/l) of the dairy cows with SARA was lower than those (1 315 µg/l) of the control dai

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Markussen, Marianne S., Marit B. Veierød, Giske Ursin, and Lene F. Andersen. "The effect of under-reporting of energy intake on dietary patterns and on the associations between dietary patterns and self-reported chronic disease in women aged 50–69 years." British Journal of Nutrition 116, no. 3 (2016): 547–58. http://dx.doi.org/10.1017/s000711451600218x.

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AbstractThe aim of this cross-sectional study was to investigate whether under-reporting of energy intake affects derived dietary patterns and the association between dietary patterns and self-reported chronic disease. Diets of 6204 women aged 50–69 years participating in the Norwegian Breast Cancer Screening Program were assessed using a 253-item FFQ. We identified dietary patterns using principal component analysis. According to the revised Goldberg cut-off method, women with a ratio of reported energy intake:estimated BMR<1·10 were classified as low energy reporters (n 1133, 18 %). We ex

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Fungomeli, Maria, Anthony Githitho, Fabrizio Frascaroli, Saidi Chidzinga, Marcus Cianciaruso, and Alessandro Chiarucci. "A new Vegetation-Plot Database for the Coastal Forests of Kenya." Vegetation Classification and Survey 1 (June 16, 2020): 103–9. http://dx.doi.org/10.3897/vcs/2020/47180.

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Biodiversity data based on standardised sampling designs are key to ecosystem conservation. Data of this sort have been lacking for the Kenyan coastal forests despite being biodiversity hotspots. Here, we introduce the Kenyan Coastal Forests Vegetation-Plot Database (GIVD ID: AF-KE-001), consisting of data from 158 plots, subdivided into 3,160 subplots, across 25 forests. All plots include data on tree identity, diameter and height. Abundance of shrubs is presented for 316 subplots. We recorded 600 taxa belonging to 80 families, 549 of which identified to species and 51 to genus level. Species

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Fungomeli, Maria, Anthony Githitho, Fabrizio Frascaroli, Saidi Chidzinga, Marcus Cianciaruso, and Alessandro Chiarucci. "A new Vegetation-Plot Database for the Coastal Forests of Kenya." Vegetation Classification and Survey 1, no. () (2020): 103–9. https://doi.org/10.3897/VCS/2020/47180.

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Biodiversity data based on standardised sampling designs are key to ecosystem conservation. Data of this sort have been lacking for the Kenyan coastal forests despite being biodiversity hotspots. Here, we introduce the Kenyan Coastal Forests Vegetation-Plot Database (GIVD ID: AF-KE-001), consisting of data from 158 plots, subdivided into 3,160 subplots, across 25 forests. All plots include data on tree identity, diameter and height. Abundance of shrubs is presented for 316 subplots. We recorded 600 taxa belonging to 80 families, 549 of which identified to species and 51 to genus level. Species

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Portuguese, Andrew J., Aya Albittar, Emily C. Liang, et al. "Lisocabtagene Maraleucel Versus Axicabtagene Ciloleucel: Efficacy and Toxicity in a Real-World Setting." Blood 142, Supplement 1 (2023): 2131. http://dx.doi.org/10.1182/blood-2023-172978.

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CD19 CAR-T therapy has revolutionized the management of high-risk and relapsed/refractory (R/R) large B-cell lymphoma (LBCL) but remains limited by significant toxicities leading to morbidity/mortality and high resource utilization. Single-arm studies have suggested differences in efficacy and toxicity across FDA-approved CD19 CAR-T products. A matching-adjusted indirect treatment comparison showed comparable efficacy and more favorable safety with lisocabtagene maraleucel (liso-cel) compared to axicabtagene ciloleucel (axi-cel), but was limited to clinical trial patients (pts) and suffered fr

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De Simoni, Ottavia, Marco Scarpa, Caterina Soldà, et al. "Could Total Neoadjuvant Therapy Followed by Surgical Resection Be the New Standard of Care in Pancreatic Cancer? A Systematic Review and Meta-Analysis." Journal of Clinical Medicine 11, no. 3 (2022): 812. http://dx.doi.org/10.3390/jcm11030812.

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Background. Total neoadjuvant therapy (TNT), intended as induction chemotherapy (IC) followed by radio-chemotherapy (RCT), has been taking hold in the treatment of pancreatic ductal adenocarcinoma (PDAC). The aim of this review is to summarize the available evidence on the role of TNT followed by curative surgery. Methods. Eligible studies were those reporting on patients with PDAC undergoing curative surgery after TNT. The primary endpoint was overall survival (OS). Results. A total of 1080 patients with PDAC who had undergone TNT were analyzed. The most common IC regimen was Gemcitabine (N 6

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Gil, Torres Alexander, and Juana Ledia Triana. "Comparación del efecto mitogénico en Escherichia coli de la insulina modificada lispro y la hormona de secuencia regular humulin." SABER 32 (July 17, 2020): 158–67. https://doi.org/10.5281/zenodo.5255872.

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<strong>RESUMEN</strong> <em>Escherichia coli</em> responde a la acción de la insulina humana y es un sistema ideal para su estudio. Hasta los momentos, no hay reportes en bacterias sobre el efecto de las insulinas modificadas utilizadas en los tratamientos de la Diabetes Mellitus (DM). En este trabajo se analizó la capacidad mitogénica de la insulina modificada Lispro (Humalog) sobre la cepa ATCC 25922 de <em>E. coli</em> en forma comparativa con la insulina de secuencia regular (Humulin). Los cultivos se realizaron en medio Luria Bertani (LB) con diversas concentraciones

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Sampson, M., M. Ruddel, and R. J. Elin. "Effects of specimen turbidity and glycerol concentration on nine enzymatic methods for triglyceride determination." Clinical Chemistry 40, no. 2 (1994): 221–26. http://dx.doi.org/10.1093/clinchem/40.2.221.

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Abstract We compared the effects of specimen turbidity and glycerol concentration on nine enzymatic methods for triglyceride measurement. We assayed 51 specimens with triglyceride concentrations of 0.85-8.21 mmol/L (75-727 mg/dL) and turbidity at 420 nm equivalent to &gt; or = 0.1 mmol/L (8.8 mg/dL) triglyceride (measured as part of our comparison method). The data were analyzed by multiple regression, which gave coefficients for the effects of glycerol concentration and the change in turbidity during the reaction. The effects of specimen turbidity and glycerol concentration were method-de

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Chernova, L. N. "ESSENTIAL TRACE ELEMENTS: POSSIBLE ROLE IN THE ETIOPATHOGENESIS OF AUTISM SPECTRUM DISORDER AND SPEECH DEVELOPMENT DELAY IN CHILDREN OF DIFFERENT AGES." Trace Elements in Medicine (Moscow) 22, no. 1 (2021): 44–51. http://dx.doi.org/10.19112/2413-6174-2021-22-1-44-51.

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An imbalance of trace elements plays a significant role in the etiopathogenesis of Autism Spec-trum Disorder (ASD) and Speech Development Delay (SDD). The aim of the study was to analyze an essential trace elements content in the hair samples of children with ASD and SDD for better understanding age and gender related diversity. The study included 258 children with ASD and 239 children with SDD. Control group consisted of 620 healthy children of similar age. All children were divided into two age categories (1.5 to 3 years old and 4 to 13 years old). It was shown that girls with ASD had more d

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Todd, MB, JA Waldron, TA Jennings, et al. "Loss of myeloid differentiation antigens precedes blastic transformation in chronic myelogenous leukemia." Blood 70, no. 1 (1987): 122–31. http://dx.doi.org/10.1182/blood.v70.1.122.122.

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Abstract In order to determine whether antigenic patterns alter with disease progression and are thereby suggestive of impending blast crisis in chronic myelogenous leukemia, 50 bone marrow biopsy specimens from 32 patients were examined retrospectively using indirect immunoperoxidase labeling with three monoclonal antibodies that detect myeloid antigens. Monoclonal antibodies PMN13F6, PMN7C3, and PMN8C7 detect human neutrophil antigens that first appear at the myeloblast, promyelocyte, and metamyelocyte stages of differentiation, respectively, and persist throughout later differentiation. Per

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Todd, MB, JA Waldron, TA Jennings, et al. "Loss of myeloid differentiation antigens precedes blastic transformation in chronic myelogenous leukemia." Blood 70, no. 1 (1987): 122–31. http://dx.doi.org/10.1182/blood.v70.1.122.bloodjournal701122.

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In order to determine whether antigenic patterns alter with disease progression and are thereby suggestive of impending blast crisis in chronic myelogenous leukemia, 50 bone marrow biopsy specimens from 32 patients were examined retrospectively using indirect immunoperoxidase labeling with three monoclonal antibodies that detect myeloid antigens. Monoclonal antibodies PMN13F6, PMN7C3, and PMN8C7 detect human neutrophil antigens that first appear at the myeloblast, promyelocyte, and metamyelocyte stages of differentiation, respectively, and persist throughout later differentiation. Percentages

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Fryburg, D. A. "Insulin-like growth factor I exerts growth hormone- and insulin-like actions on human muscle protein metabolism." American Journal of Physiology-Endocrinology and Metabolism 267, no. 2 (1994): E331—E336. http://dx.doi.org/10.1152/ajpendo.1994.267.2.e331.

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The effect of a 6-h intra-arterial infusion of recombinant human (rh) insulin-like growth factor I (IGF-I) on forearm muscle metabolism was studied in 19 postabsorptive subjects. Forearm glucose, lactate, and phenylalanine (Phe) balances, as well as estimates of protein degradation (Phe Ra) and synthesis (Phe Rd) were measured before and at 3 and 6 h into an infusion of rhIGF-I at a dose of 1.8 (n = 6), 6.0 (n = 8), or 10.0 (n = 5) micrograms.kg-1.h-1. In response to intra-arterial IGF-I, deep venous IGF-I rose by 55, 141, and 315%, respectively (all P < 0.01), and forearm blood flow accele

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Plavec, Tanja, Žiga Žagar, and Martin Kessler. "Klinisch-pathologische Befunde, postoperative Überlebenszeiten und prognostische Faktoren bei Hunden mit primären Lungenkarzinomen." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 50, no. 05 (2022): 317–28. http://dx.doi.org/10.1055/a-1949-0125.

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Zusammenfassung Einleitung Primäre Karzinome der Lunge (PLK) beim Hund sind selten, ihre Behandlung erfolgt chirurgisch. Ziel dieser Studie war die Untersuchung klinisch-pathologischer Befunde, postoperativer medianer Überlebenszeiten (mÜZ) und prognostischer Faktoren. Material und Methoden Retrospektive Auswertung von 61 Hunden mit 62 PLK, die zwischen 2007 und 2017 chirurgisch behandelt wurden. Die statistische Auswertung erfolgte mittels Kaplan-Meier und Logrank Methoden. Ergebnisse Von 62 PLKs lagen 35 (56 %) peripher im Lungenlappen, 21 (34 %) hilusnah und 6 (10 %) betrafen den gesamten L

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Quintela-Fandino, Miguel, Ricardo Hitt, Pedro P. Medina, et al. "DNA-Repair Gene Polymorphisms Predict Favorable Clinical Outcome Among Patients With Advanced Squamous Cell Carcinoma of the Head and Neck Treated With Cisplatin-Based Induction Chemotherapy." Journal of Clinical Oncology 24, no. 26 (2006): 4333–39. http://dx.doi.org/10.1200/jco.2006.05.8768.

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Purpose Cisplatin kills tumor cells through DNA cross linking. Alterations in the function of DNA repair genes may affect DNA repair proficiency and influence cancer patients' response to cisplatin. We studied whether single nucleotide polymorphisms (SNPs) of DNA repair genes predict the response to cisplatin or prognosis in patients with squamous cell carcinoma of the head and neck (SCCHN). Methods A polymerase chain reaction–restriction fragment length polymorphism (RFLP) approach was used to determine the frequency of the SNPs: XPD-Asp312Asn, XPD-Lys751Gln, ERCC1-C8092A, and XRCC1-Arg399Gln

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Tiu, Ramon V., Lukasz P. Gondek, Christine L. O'Keefe, et al. "New Lesions Detected by Single Nucleotide Polymorphism Array–Based Chromosomal Analysis Have Important Clinical Impact in Acute Myeloid Leukemia." Journal of Clinical Oncology 27, no. 31 (2009): 5219–26. http://dx.doi.org/10.1200/jco.2009.21.9840.

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PurposeCytogenetics is the primary outcome predictor in acute myeloid leukemia (AML). Metaphase cytogenetics (MC) detects an abnormal karyotype in only half of patients with AML, however. Single nucleotide polymorphism arrays (SNP-A) can detect acquired somatic uniparental disomy (UPD) and other cryptic defects, even in samples deemed normal by MC. We hypothesized that SNP-A will improve detection of chromosomal defects in AML and that this would enhance the prognostic value of MC.Patients and MethodsWe performed 250K and 6.0 SNP-A analyses on 140 patients with primary (p) and secondary (s) AM

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Codl, Radim, Jaromír Ducháček, Mojmír Vacek, Jan Pytlík, Luděk Stádník, and Marek Vrhel. "Relationship between daily activities duration and oestrus in dairy cows over the year." Acta Veterinaria Brno 91, no. 1 (2022): 11–16. http://dx.doi.org/10.2754/avb202291010011.

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The aim of this study was to evaluate the amounts of time that selected crossbreeds of Holstein (H), Red-Holstein (R), and Czech Fleckvieh (C) cattle spent chewing, eating, being physically active using a Vitalimetr 5P neck responder during the period around oestrus in all seasons of the year. Oestrus and the days preceding it greatly affected the times of events of increased activity, eating, and rumination. Eating and chewing times were longest for H cows, at 51–74%, and shortest for C cows, at > 88%. The number of events of increased activity was highest (533.4 ± 8.94 events, P < 0.01

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Sonnenberg, H., U. Honrath, and D. R. Wilson. "Effects of increased perfusion pressure on medullary collecting duct function." Canadian Journal of Physiology and Pharmacology 68, no. 3 (1990): 402–7. http://dx.doi.org/10.1139/y90-056.

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The role of the medullary collecting duct in pressure natriuresis has not been established. In vivo microcatheterization was used to study the effect of an acute increase in blood pressure induced by bilateral carotid artery and vagal nerve ligation on medullary collecting duct function in anaesthetized rats. Increased fluid and electrolyte excretion during pressure natriuresis were accompanied by increased delivery of water, sodium, chloride, and potassium to the beginning of the medullary collecting duct, a change that was significantly greater than in a second series of time-control animals

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Corti, Chiara, Tianyu Li, Alyssa R. Martin, et al. "Abstract P5-10-17: Impact of Pathologic Response and Individual Prognosis After Neoadjuvant Treatment (NAT) in Patients (pts) with Early HER2+ and Triple-Negative Breast Cancer (TNBC)." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–10–17—P5–10–17. https://doi.org/10.1158/1557-3265.sabcs24-p5-10-17.

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Abstract Background: Pathologic complete response (pCR) is prognostic in pts with early breast cancer (eBC). This study aims to assess individual prognostic factors for recurrence-free survival (RFS) and overall survival (OS) in pts with pCR vs residual disease (RD). Methods: This retrospective study included pts diagnosed at our institution with TNBC or HER2+ eBC who underwent surgery post-NAT and had available data for pCR/RD, RFS, OS. Clinical tumor size (cT), nodal status (cN), and subtype were evaluated as prognostic factors using Cox models and Kaplan-Meier method, in all pts and in pts

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Breiter, Karel, Michaela Vaňková, Michaela Vašinová Galiová, Zuzana Korbelová, and Viktor Kanický. "Lithium and trace-element concentrations in trioctahedral micas from granites of different geochemical types measured via laser ablation ICP-MS." Mineralogical Magazine 81, no. 1 (2017): 15–33. http://dx.doi.org/10.1180/minmag.2016.080.137.

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AbstractThe compositions of trioctahedral micas from 51 samples of granitoids with different geochemical affiliations and grades of differentiation from the Bohemian Massif, Central Europe, were analysed using electron microprobe (major elements) and laser ablation inductively coupled plasma mass spectrometry (Li, Sc, Ga, Ge, Nb, In, Sn, Cs, Ta, W, Tl). The micas form a continuous evolutionary series from phlogopite to zinnwaldite. The phlogopites and biotites from the I-type rocks are characterized by 5.5–5.7 Si, 2.4–2.6 Al, <0.1 Li atoms per formula unit [apfu] and Mg/(Mg + Fe) = 0.4–0.8.

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KAIPOV, ARTUR E., ROIN K. GEORGIKIA, ILDAR V. ABDULYANOV, et al. "PULMONARY HYPERTENSION INFLUENCE ON OUTCOMES OF SECONDARY TRICUSPID INSUFFICIENCY CORRECTION IN PATIENTS FOR VALVULAR HEART DISEASE." Bulletin of Contemporary Clinical Medicine 15, no. 1 (2022): 43–51. http://dx.doi.org/10.20969/vskm.2022.15(1).43-51.

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Aim. The aim of the study is to compare the effect of pulmonary hypertension on the outcome of tricuspid valve plasty in the groups with moderate and significant pulmonary hypertension. Material and methods. The results of surgical treatment of 620 patients with cardiac valve diseases were analyzed. Pulmonary artery systolic pressure (PASP) measured by echocardiography. Two groups were distinguished: Group 1 – pulmonary artery systolic pressure ˂ 50 mmHg. – 250 patients, Group 2-systolic pulmonary artery pressure ≥50 mm Hg. – 370 patients. Depending on the method of tricuspid insufficiency cor

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Li, Xin, Noel A. Brownlee, Thomas A. Sporn, Annabelle Mahar, and Victor L. Roggli. "Malignant (Diffuse) Mesothelioma in Patients With Hematologic Malignancies: A Clinicopathologic Study of 45 Cases." Archives of Pathology & Laboratory Medicine 139, no. 9 (2015): 1129–36. http://dx.doi.org/10.5858/arpa.2014-0569-oa.

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Context Ionizing radiation has a role in the development of malignant mesothelioma, in several epidemiologic studies, including patients with hematologic malignancies. Objective To study the clinicopathologic characteristics of patients with malignant mesothelioma and hematologic malignancies with and without a history of radiotherapy. Design From a database of approximately 3600 patients with malignant mesothelioma, we identified 45 patients (1%) who also had hematologic malignancies. We examined clinicopathologic features and noted whether the patient had received radiotherapy for malignancy

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Struyf, E., W. Opdekamp, H. Backx, S. Jacobs, D. J. Conley, and P. Meire. "Vegetation and proximity to the river control amorphous silica storage in a riparian wetland (Biebrza National Park, Poland)." Biogeosciences 6, no. 4 (2009): 623–31. http://dx.doi.org/10.5194/bg-6-623-2009.

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Abstract. Wetlands can modify and control nutrient fluxes between terrestrial and aquatic ecosystems, yet little is known of their potential as biological buffers and sinks in the biogeochemical silica cycle. We investigated the storage of amorphous silica (ASi) in a central-European riparian wetland. The variation in storage of ASi in the soil of an undisturbed wetland was significantly controlled by two factors: dominance of sedges and grasses and distance to the river (combined (R2=78%). Highest ASi storage was found near the river and in sites with a dominance of grasses and sedges, plants

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Sekeres, Mikkael A., Jaroslaw P. Maciejewski, David W. Donley, et al. "A Study Comparing Dosing Regimens and Efficacy of Subcutaneous to Intravenous Azacitidine (AZA) for the Treatment of Myelodysplastic Syndromes (MDS)." Blood 114, no. 22 (2009): 3797. http://dx.doi.org/10.1182/blood.v114.22.3797.3797.

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Abstract Abstract 3797 Poster Board III-733 Background AZA, the most commonly used disease-modifying therapy for MDS in the US, demonstrates a survival advantage in higher-risk (International Prognostic Scoring System [IPSS] Int-2, High, or excess blasts) MDS subtypes. It was approved by the US FDA in 2004 as a 7-day per 28-day, subcutaneous (SC) regimen, based on response rates, with the 7-day intravenous (IV) route approved in 2007 based on efficacy data from the CALGB 8421 study and pharmacokinetic data. This registry allows for the evaluation of community based practices for dosing and eff

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