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Journal articles on the topic '621.391 (0.43)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Dyball, S., M. Rodziewicz, A. V. Madenidou, et al. "OP0013 APPLYING STANDARD CLASSIFICATION CRITERIA EXCLUDES UP TO A HALF OF ALL PATIENTS FROM CONNECTIVE TISSUE DISEASES (CTD) CLINICAL TRIALS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 9. http://dx.doi.org/10.1136/annrheumdis-2023-eular.522.

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BackgroundClassification criteria aim to identify a homogenous population of patients with a high specificity for clinical research.ObjectivesTo determine how connective tissue disease (CTD) phase III trials utilise classification criteria within their inclusion and exclusion criteria. We then applied the most commonly used classification criteria to a large cohort of patients with an existing CTD diagnosis to explore which patients would be included and excluded from trials.MethodsA comprehensive review of all major published phase III trials in CTDs was performed using clinicaltrials.gov (No

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Chiara, S., S. Lastraioli, P. Marroni, et al. "Polymorphisms in UGT1A gene family and irinotecan toxicity in patients with advanced colorectal cancer." Journal of Clinical Oncology 24, no. 18_suppl (2006): 13049. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.13049.

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13049 Background: The irinotecan active metabolite, SN38, is inactivated through glucuronidation mainly by uridine diphosphate glucuronosyltransferase (UGT) 1A1. The (TA)7 allele of a polymorphism in UGT1A1 promoter has been associated with reduced SN38-glucuronidation rate and more severe toxicity. Since other UGT1A family isoforms, the extrahepatic UGT1A7 and the hepatic UGT1A9, are involved in SN38 glucuronidation, it has been suggested that also polymorphic variants of these genes may affect irinotecan toxicity. Methods: 84 patients with advanced colorectal cancer received an irinotecan-ba

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Romero, D., G. Romero, G. Veneranda, L. Filippi, D. Racca, and G. A. Bó. "18 PREGNANCY RATES IN LACTATING DAIRY COWS TREATED WITH GONADOTROPIN-RELEASING HORMONE-BASED SYNCHRONIZATION PROGRAMS AND INSEMINATED AT A FIXED TIME." Reproduction, Fertility and Development 25, no. 1 (2013): 156. http://dx.doi.org/10.1071/rdv25n1ab18.

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An experiment was designed to compare pregnancy rates in lactating dairy cows synchronized with a 7-day CIDR-Synch or a 5-day CIDR-Synch program and to determine if the addition of a second prostaglandin F2α (PGF) injection to the 7-day CIDR-Synch program would improve pregnancy rates following fixed-time AI (FTAI). The experiments were performed on 2 dairy farms in Argentina, with year-round calving and a mixed feeding system (35% grazing plus 65% corn silage and grain). Cows (n = 621) were 39.3 ± 6.5 days in milk (DIM, mean ± SD) when they were enrolled in the program, had 2.4 ± 1.5 lactatio

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Zahalka, Ali, George Haines III, Vitaly Margulis, and Ashutosh K. Tewari. "An open-label phase 1, window-of-opportunity study of ultrasound-guided long acting periprostatic neuraxial block with ethanol in patients with high-risk prostate cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 391. https://doi.org/10.1200/jco.2025.43.5_suppl.391.

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391 Background: Patients (pts) with high-risk prostate cancer (PCa) have an elevated risk of disease recurrence/progression after definitive therapy. These pts also exhibit increased levels of adrenergic nerve density on PCa histology. Pre-clinical evidence from murine models of PCa suggest that PCaNeurolysis of periprostatic adrenergic nerves inhibits cancer progression and metastasis by inhibiting angiogenesis, altering cancer metabolism, and inhibiting cell migration (PMC5783182). Pure Ethanol (>99%) injection for neurolysis is FDA-approved in chronic cancer pain and may have a survival

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Oto, Hanuš, Křížová Ludmila, Hajšlová Jana, et al. "Effect of increasing zearalenone levels on the coagulation properties of milk and the viability of yogurt bacteria." Czech Journal of Food Sciences 36, No. 4 (2018): 277–83. http://dx.doi.org/10.17221/391/2017-cjfs.

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The effect of increasing levels of zearalenone (ZEA) artificially supplemented to milk on the coagulation characteristics and the viability of Lactobacillus bulgaricus and Streptococcus thermophilus was examinated. Cow milk was inoculated with the yogurt culture YC-180 – YO-Flex and divided into 72, 25-ml flasks. Two samples were collected before fermentation (0 h) and remaining 70 flasks were divided into 7 groups – control (C), Z0 with 0.5 ml of ethanol and Z10, Z100, Z250, Z500, and Z1000 that were spiked with ZEA to reach the final ZEA concentrations of 10, 100, 250, 500, and 1000 µg/l, re

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Huang, Tao, Terri Beaty, Ji Li, Huijuan Liu, Wei Zhao, and Youfa Wang. "Association between dietary fat intake and insulin resistance in Chinese child twins." British Journal of Nutrition 117, no. 2 (2017): 230–36. http://dx.doi.org/10.1017/s0007114516004542.

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AbstractDietary fat intake is correlated with increased insulin resistance (IR). However, it is unknown whether gene–diet interaction modulates the association. This study estimated heritability of IR measures and the related genetic correlations with fat intake, and tested whether dietary fat intake modifies the genetic influence on type 2 diabetes (T2D)-related traits in Chinese child twins. We included 622 twins aged 7–15 years (n 311 pairs, 162 monozygotic (MZ), 149 dizygotic (DZ)) from south-eastern China. Dietary factors were measured using FFQ. Structural equation models were fit using

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Alluaibi, Abutalib B., Bahaa K. Hassan, Alaa H. Ali, and Ahmed A. Muhsen. "Determinants of conversion during laparoscopic cholecystectomy among a sample of Iraqi patients." International Surgery Journal 5, no. 7 (2018): 2455. http://dx.doi.org/10.18203/2349-2902.isj20182462.

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Background: Laparoscopic cholecystectomy has become a standard technique for gall bladder surgery of symptomatic cholelithiasis. However, conversion to open cholecystectomy is sometimes necessary. The aim of the present study was to assess the predictive factors that increase the possibility of conversion of laparoscopic cholecystectomy to open cholecystectomy.Methods: A total of 621 laparoscopic cholecystectomies were attempted at AL-Mawanee General Hospital and AL-Sader Teaching Hospital in Basrah, IRAQ from June 2012 till June 2016.Of these,43 had to be converted to open cholecystectomies.

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Perfil'ev, Nikolay, and Ol'ga V'yushina. "TILLAGE SYSTEMS INFLUENCE ON MOISTURE RESERVES, WATER CONSUMPTION AND BARLEY YIELDS." Bulletin of KSAU, no. 9 (October 29, 2024): 36–43. https://doi.org/10.36718/1819-4036-2024-9-36-43.

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The aim of research is to establish the influence of primary tillage systems of dark gray forest soil in the Northern Trans-Urals on moisture availability, water consumption of spring barley crops and its yield. The paper presents the results of long-term studies conducted in the northern forest-steppe of the Tyumen Region in a stationary experiment on average for the period of the 7th rotation of the grain-fallow crop rotation (2018–2022). All studied primary tillage systems during the sowing-emergence period had an equivalent effect on the reserves of productive moisture in the 0–30 and 0–10

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Johnson, Bruce E., Mark G. Kris, Lynne D. Berry, et al. "A multicenter effort to identify driver mutations and employ targeted therapy in patients with lung adenocarcinomas: The Lung Cancer Mutation Consortium (LCMC)." Journal of Clinical Oncology 31, no. 15_suppl (2013): 8019. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8019.

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8019 Background: The detection of driver mutations in the EGFR and ALK genes and targeted therapy has transformed treatment of lung cancer. The LCMC was established in 2009 to assay lung adenocarcinomas for driver genomic alterations in 10 genes and to study and treat patients by their molecular subtypes. Methods: The 14-member LCMC enrolled patients with metastatic adenocarcinoma of the lung and tested their tumors in CLIA laboratories for KRAS, EGFR, HER2, BRAF, PIK3CA, AKT1, MEK1, and NRAS mutations using multiplexed assays, and for ALK rearrangements and MET amplifications using fluorescen

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Foeldvari, I., J. Klotsche, O. Kasapcopur, et al. "POS0079 PATIENTS WITH JUVENILE SYSTEMIC SCLEROSIS HAVE A DISTINCT PATTERN OF ORGAN INVOLVEMENT.RESULTS FROM THE JUVENILE SYSTEMIC SCLEROSIS INCEPTION COHORT. WWW.JUVENILE-SCLERODERMA.COM." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 247.2–247. http://dx.doi.org/10.1136/annrheumdis-2021-eular.799.

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Background:Juvenile systemic sclerosis (jSSc) is a rare disease with a prevalence of around 3 in 1,000,000 children. To better capture the clinical manifestations of jSSc the juvenile systemic sclerosis inception cohort (jSScC) has been prospectively enrolling patients with predetermined clinical variables over the past 12 years. One of the goals is to study the demographic, clinical features, and physician and patient reported outcome differences between those with juvenile limited cutaneous (lc) compared to diffuse cutaneous (dc) disease subtypes, to determine if characteristics are similar

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Falconer, J., J. A. Owens, E. Allotta, and J. S. Robinson. "Effect of restriction of placental growth on the concentrations of insulin, glucose and placental lactogen in the plasma of sheep." Journal of Endocrinology 106, no. 1 (1985): 7–11. http://dx.doi.org/10.1677/joe.0.1060007.

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ABSTRACT The effect of restricting placental growth on maternal glucose, insulin and placental lactogen was investigated in 16 ewes carrying singleton lambs. Uterine caruncles were removed from seven ewes (caruncle ewes) before pregnancy, resulting in reduced placental size and retarded intra-uterine fetal growth. The concentration of insulin in maternal plasma was similar in both control and caruncle ewes. The concentration of glucose was significantly higher in the caruncle than in the control ewes (3·26 ± 0·15 (s.e.m.) mmol/l, number of observations (n) = 9, vs 2·75 ± 0·1, n = 9, P<0·02,

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Chen, Yu-ming, Birgit Teucher, Xin-yi Tang, et al. "Calcium absorption in postmenopausal Chinese women: a randomized crossover intervention study." British Journal of Nutrition 97, no. 1 (2007): 160–66. http://dx.doi.org/10.1017/s0007114507210141.

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The Ca intake and food sources of Chinese postmenopausal women are quite different from those of their Western counterparts. But, little information on Ca metabolism is available in Chinese populations. We determined true fractional calcium absorption (TFCA), true Ca absorption ( = TFCA × Ca intake,Va), urinary Ca excretion (Vu) and the difference betweenVaandVu(Va − u), in response to three dietary Ca intake levels. Twenty-one healthy postmenopausal Chinese women aged 49–64 years were recruited for this randomized crossover trial from a general community, Guangzhou, China. Subjects were rando

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Crabtree, Robert H. "Progress in Inorganic Chemistry. Volume 43 Edited by Kenneth D. Karlin (Johns Hopkins University). Wiley: New York. 1995. vi + 621 pp. $125.00. ISBN 0-471-12336-6." Journal of the American Chemical Society 118, no. 28 (1996): 6806. http://dx.doi.org/10.1021/ja955350d.

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Kumar, Shaji, Ian W. Flinn, Paul G. Richardson, et al. "Novel Three- and Four-Drug Combination Regimens of Bortezomib, Dexamethasone, Cyclophosphamide, and Lenalidomide, for Previously Untreated Multiple Myeloma: Results From the Multi-Center, Randomized, Phase 2 EVOLUTION Study." Blood 116, no. 21 (2010): 621. http://dx.doi.org/10.1182/blood.v116.21.621.621.

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Abstract Abstract 621 Background: Two- and three-drug regimens incorporating bortezomib (Velcade®, V), lenalidomide (Revlimid®, R), dexamethasone (D), or cyclophosphamide (C) have been shown to be effective and well tolerated in previously untreated multiple myeloma (MM). Combining all four drugs in a single regimen (VDCR) may further enhance efficacy. Published results from the phase 1 dose-escalation portion of the non-comparative, multi-center EVOLUTION study showed that the VDCR regimen was highly active and generally well tolerated (Kumar et al Leukemia 2010). Here we present updated resu

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Bedoya, S. A. O., M. V. Souza, L. G. Conceição, et al. "Quantificação do colágeno dérmico equino por duas técnicas morfométricas: contagem de pontos e segmentação de cor." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 71, no. 3 (2019): 761–69. http://dx.doi.org/10.1590/1678-4162-10487.

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RESUMO Os colágenos tipos I e III apresentam diferentes tonalidades de birrefringência em cortes histológicos corados com Picrosirius red e analisados em microscópio sob luz polarizada. Com base nessa propriedade, os colágenos podem ser quantificados por histomorfometria. Entretanto, são muitas as variáveis que podem afetar a distribuição das cores na imagem histológica, e a escolha adequada dos parâmetros de análise têm grande influência no resultado final. O objetivo deste trabalho foi comparar a quantificação histomorfométrica de colágeno em pele equina pela morfometria por contagem de pont

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TEDESCHI, L. O., A. CANNAS, S. G. SOLAIMAN, R. A. M. VIEIRA, and N. K. GURUNG. "Development and evaluation of empirical equations to predict ruminal fractional passage rate of forages in goats." Journal of Agricultural Science 150, no. 1 (2011): 95–107. http://dx.doi.org/10.1017/s0021859611000591.

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SUMMARYThe objectives of the present paper were to develop and evaluate empirical equations to predict fractional passage rate (kp) of forages commonly fed to goats using chemical composition of the diet and animal information. Two databases were created. The first (development database) was assembled from four studies that had individual information on animals, diets and faecal marker concentrations over time (up to 120 h post-feeding); it contained 54 data points obtained from Latin square designs. The second (evaluation database) was built using published information gathered from the liter

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Ruiz, Ortiz Martín, Cristina Ogayar, Elías Romo, et al. "Long-term survival in elderly patients with stable coronary disease." European Journal of Clinical Investigation 43, no. 8 (2013): 774–82. https://doi.org/10.1111/eci.12105.

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<strong>Background: </strong>This study aimed to assess long-term prognosis of stable coronary artery disease (sCAD) in patients aged ≥ 75 years and to identify clinical predictors of cardiovascular and overall mortality. <strong>Materials and methods: </strong>From February 2000 to January 2007, 391 outpatients aged ≥ 75 years (median 78 years, interquartile range [IQR] 76-81 years, 66% male) with sCAD were recruited in this prospective cohort study. Associations of baseline variables with long-term cardiovascular and all-cause death were investigated. <strong>Results: </

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MURAYAMA, NOBUKO, AYU MATSUNAGA, LADDA TANGBANLUEKAL, SUWALEE TANTAWIWAT, and RYUTARO OHTSUKA. "EFFECTS OF ORAL CONTRACEPTIVE USE ON BODY MASS INDEX AND BLOOD PRESSURE AMONG FEMALE VILLAGERS IN NORTH-EAST THAILAND." Journal of Biosocial Science 35, no. 2 (2003): 243–61. http://dx.doi.org/10.1017/s0021932003002438.

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The use of contraceptives has become prevalent among females in Thailand in the past 20 years, and oral contraceptive use has been suggested to trigger changes in fat intake, energy expenditure, fat metabolism and blood pressure. Based on field investigations of 391 married women aged 20 years or over in Yasothon Province, North-east Thailand, this study aims to elucidate the effects of oral contraceptive use on body mass index (BMI: kg/m2 ) and blood pressure, taking into account reproductive histories and socioeconomic conditions. The proportion of obese (BMI> 25) subjects was high in the

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Muniz, Thiago Pimentel, Victor Hugo Fonseca Jesus, Victor Aurelio Ramos Sousa, malu barbosa, and Vladmir Claudio Cordeiro De Lima. "A modified recursive partitioning analysis for predicting overall survival in patients with non-small cell lung cancer and central nervous system metastases." Journal of Clinical Oncology 37, no. 15_suppl (2019): e20604-e20604. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e20604.

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e20604 Background: Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers. Most patients with NSCLC have metastases at diagnosis and 30-50% of them will present brain lesions during follow-up. Nonetheless, patients with central nervous system (CNS) spread are poorly represented in clinical trials and the management of this clinical scenario is not standardized. Prognostic tolls are needed to help to guide the best approach for these patients. Methods: Descriptive, analytical, retrospective, single center study. Patients > 18 years of age diagnosed with NSCLC who developed CNS m

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Comer, M. B., D. L. Campbell, R. L. Rasmusson, et al. "Cloning and characterization of an Ito-like potassium channel from ferret ventricle." American Journal of Physiology-Heart and Circulatory Physiology 267, no. 4 (1994): H1383—H1395. http://dx.doi.org/10.1152/ajpheart.1994.267.4.h1383.

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FK1, a ferret ventricular full-length cDNA clone, encodes a 654-amino acid protein with 98% identity to human K+ transient outward current (Ito)-like HK1 (Tamkun et al. FASEB J.5: 331-337, 1991). FK1 is detectable in ferret brain, atrium, left and right ventricle, and kidney but not in skeletal muscle, endothelial cells, aorta, and liver. In Xenopus oocytes, FK1 cRNA gives rise to a rapidly activating and inactivating Ito-like current, which is highly K+ selective (Na(+)-to-K+ permeability ratio = 0.003). Activation occurs over an approximately 50-mV range (-40 to +10 mV) and displays a sigmoi

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Harrison, Melissa, Beverly Bell, Allen Chauvenet, Joanne Kurtzberg, Bruce Camitta, and Meenakshi Devidas. "Testicular Relapse in Lesser, Standard, and High Risk Patients Treated with Frontline Therapy for Childhood ALL. Pediatric Oncology Group Protocols 9201, 9405, 9605, and 9406." Blood 108, no. 11 (2006): 1863. http://dx.doi.org/10.1182/blood.v108.11.1863.1863.

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Abstract From 1984–94, testicular relapse (TR) was reported in 10–20% of boys with ALL. Addition of intermediate and higher dose methotrexate (MTX) in subsequent trials may have reduced this risk. Pediatric Oncology Group (POG) trials 9201, 9405, 9605, and 9406 for B-precursor ALL opened in 1994–6. Protocol 9201 enrolled 365 lesser risk, 9405: 158 standard risk, 9605: 601 standard risk, and 9406: 512 higher risk (total 1,636) boys with ALL. All studies used a common induction protocol of L-asparaginase, vincristine, and prednisone. Doxorubicin was added for higher risk (based on age, initial W

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Masarova, Lucia, Naval Daver, Naveen Pemmaraju, et al. "Do Patients with Post-Essential Thrombocythemia and Post-Polycythemia Vera Differ from Patients with Primary Myelofibrosis?" Blood 126, no. 23 (2015): 4069. http://dx.doi.org/10.1182/blood.v126.23.4069.4069.

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Abstract Introduction: Clinical characteristics of post-essential thrombocythemia/polycythemia vera myelofibrosis "post ET/PV-MF" are not well defined as for primary myelofibrosis "MF". Objective: We aimed to identify morphological, clinical and prognostic characteristics of patients with post ET/PV-MF seen at our center. Methods: Retrospective chart review of 1120 patients with MF - 766 primary MF, 354 post ET/PV-MF, who were referred to our institution between years 1984-2013 was performed; 92% presented after the year of 2000. Fisher's exact and Mann-Whitney test were used for categorical a

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Wasan, Harpreet, Richard A. Adams, Richard H. Wilson, et al. "Intermittent chemotherapy (CT) plus continuous or intermittent cetuximab (C) in the first-line treatment of advanced colorectal cancer (aCRC): Results of the two-arm phase II randomized MRC COIN-B trial." Journal of Clinical Oncology 30, no. 4_suppl (2012): 536. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.536.

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536^ Background: COIN-B is a trial of intermittent chemotherapy (ICT) plus intermittent cetuximab (C) vs ICT plus continuous C in the first-line treatment of aCRC. It complements the COIN trial by investigating how C might safely and effectively be added to an ICT strategy. Methods: Patients (pts) had measurable aCRC; no prior CT for metastases; WHO PS 0-2 and good organ function. Randomisation was: Arm D - continuous OxFU + weekly C for 12 wks then a planned break from all therapy; Arm E - OxFU + weekly C for 12 wks then weekly C. Upon RECIST progression on either arm, OxFU (or FU) plus C was

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Glassman, Danielle C., Avni Mukund Desai, Geoffrey Yuyat Ku, et al. "Nano-liposomal irinotecan and 5-FU/LV (N+F) for the treatment of advanced PDAC: Memorial Sloan Kettering (MSK) Single Cancer Center Evaluation." Journal of Clinical Oncology 36, no. 4_suppl (2018): 471. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.471.

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471 Background: Therapy options for advanced pancreatic adenocarcinoma (PDAC) are finite. NAPOLI-1, a phase III randomized trial, demonstrated the efficacy of N+F following progression on gemcitabine (G) based therapy (mPFS 3.1 mo, mOS 6.1 mo). There are limited additional data on the safety and efficacy of N+F following FDA approval in October 2015. We examined the post approval safety, tolerability and effectiveness of N+F in advanced PDAC patients at MSK. Methods: A retrospective chart review was conducted of all patients treated with N+F from Feb 2016 and ending in Aug 2017. Using the EMR

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Cáceres Manrique, Flor De María, and Myriam Ruiz-Rodríguez. "Prevalencia de inicio tardío de la atención prenatal. Asociación con el nivel socioeconómico de la gestante. Estudio de corte transversal. Bucaramanga, Colombia, 2014-2015." Revista Colombiana de Obstetricia y Ginecología 69, no. 1 (2018): 22. http://dx.doi.org/10.18597/rcog.3034.

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Objetivo: describir la prevalencia del inicio tardío de la atención prenatal y evaluar su asociación con el estrato socioeconómico donde habita la gestante.Materiales y métodos: estudio de corte transversal. Se incluyeron gestantes procedentes del área urbana de Bucaramanga, seleccionadas por muestreo por cuotas con afijación proporcional por estrato socioeconómico, según la clasificación socioeconómica del barrio donde habitan. Se consideró inicio tardío haber comenzado atención prenatal (APN) a las 12 semanas o más de gestación. Se evaluó asociación del inicio tardío con el estrato socioecon

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Nagra, D., K. Bechman, M. Russell, et al. "AB0442 RETROSPECTIVE ANALYSIS ON JAK INHIBITORS AT SINGLE CENTRE IN THE UK." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1409.2–1410. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2535.

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BackgroundThere are limited real world data on the use of JAK inhibitors (JAKi). In 2022, the EMA suggested that JAKi should only be used if alternative therapies are not available in patients over 65 years, smokers or in those with cardiovascular or cancer risk factors.ObjectivesWe conducted a retrospective study to describe the demographics, duration of therapy and adverse events profile of patients prescribed JAKi.MethodsBaseline data including age, gender, smoking status, ethnicity, co-morbidities, cardiovascular risk factors, rheumatic diagnosis, concomitant csDMARD use and prior biologic

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Shanafelt, Tait D., Betsy R. LaPlant, Timothy G. Call, et al. "Randomized Phase II Trial of Pentostatin, Cyclophosphamide, and Rituximab with or without Concurrent Avastin for Previously Untreated B-Chronic Lymphocytic Leukemia (CLL)." Blood 124, no. 21 (2014): 4673. http://dx.doi.org/10.1182/blood.v124.21.4673.4673.

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Abstract BACKGROUND: Although chemoimmunotherapy (CIT) has improved response rates, treatment free survival, and overall survival in patients with chronic lymphocytic leukemia (CLL), only 40-50% of patients achieve a complete remission and the majority have residual disease when evaluated using sensitive assays. Interactions with nurturing environments can enhance CLL B-cell resistance to apoptosis. These interactions include cytokine mediated prosurvival signals by angiogenic molecules, such as VEGF and bFGF that nurture CLL B-cells in an autocrine fashion and promote CLL cell survival partly

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Andreoli, L., M. C. Gerardi, F. Crisafulli, et al. "OP0125 THE MANAGEMENT OF PREGNANCY IN AUTOIMMUNE RHEUMATIC DISEASES: ANALYSIS OF 758 PREGNANCIES FROM THE PROSPECTIVE NATIONWIDE P-RHEUM.IT STUDY (THE ITALIAN REGISTRY OF PREGNANCY IN THE RHEUMATIC DISEASES)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 81.1–81. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1431.

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BackgroundPregnancy is a topic of fundamental importance for women living with autoimmune rheumatic diseases (ARD). Efforts at national and international levels have been put in the collection and harmonization of data in order to implement an evidence-based management of pregnant patients.ObjectivesThe P-RHEUM.it study was designed as a nationwide, web-based longitudinal observational cohort study to collect data about pregnancy in ARD in 26 centers in Italy. The study started in May 2018 and has been supported by the Italian Society for Rheumatology.MethodsPregnant patients with a definite r

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Vasu, Sumithira, Maria Berg, Andreas Lundqvist, et al. "A Highly Efficient Method to Expand CD3-CD56+ NK Cells from Cord Blood Segments." Blood 112, no. 11 (2008): 3902. http://dx.doi.org/10.1182/blood.v112.11.3902.3902.

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Abstract Background: The infusion of in-vitro expanded cord blood derived CD3−CD56+ NK cells could potentially be used to enhance graft-vs-tumor effects following cord blood transplantation. In order to infuse NK cells derived from the same cord unit used during allogeneic transplantation, we sought to develop a highly efficient culture method to expand large numbers of NK cells in vitro from < 1 ml of cord blood. Methods: Immunomagnetic beads were used to deplete CD3+ T-cells from thawed cord blood. CD3 depleted mononuclear cells (<0.1% CD56+) were co-cultured with either irradiated EBV

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Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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Choi, Yong Won, Mi Sun Ann, Hyun Woo Lee, Seok Yun Kang, and Jin-Hyuk Choi. "Is surgical resection beneficial in recurrent or metastatic gastric cancer?" Journal of Clinical Oncology 35, no. 15_suppl (2017): 4043. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.4043.

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4043 Background: Although chemotherapy is currently established as a standard treatment in recurrent or metastatic gastric cancer, the role of palliative surgical resection is still controversial. We investigated the survival benefit of surgical resection in patients (pts) with recurrent or metastatic gastric cancer who received systemic chemotherapy. Methods: A retrospective review was conducted on 698 pts who received palliative chemotherapy for recurrent (n = 307) or primary metastatic (n = 391) gastric cancer. Overall survival (OS) of pts who underwent surgical resection followed by chemot

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Kutluk, M. T., and M. A. Yeşilipek. "Pediatric Cancer Registry in Turkey (Turkish Pediatric Oncology Group & Turkish Pediatric Hematology Association)." Journal of Global Oncology 4, Supplement 2 (2018): 67s. http://dx.doi.org/10.1200/jgo.18.25100.

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Background: Each year more than 200,000 new cancer cases are expected in children & adolescents aged 0-14 years at global level. Although the long term survival rates have been improved to 85% in high income countries, it is still lower than this LMICs with a wide range around the world. Pediatric registries are critical for planning for pediatric cancer care. This study summarizes the update of pediatric cancer registry in Turkey. Aim: To analyze the pediatric cancer distribution through Turkish Pediatric Cancer Registry for the years of 2009-2017. Method: Turkish Pediatric Oncology Group

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Kádár, Imre. "Műtrágyázás hatása a telepített gyep termésére és N-felvételére 1." Gyepgazdálkodási Közlemények 2, no. 1-2 (2021): 36–45. http://dx.doi.org/10.55725/gygk/2004/2/1-2/10461.

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Egy műtrágyázási tartamkísérlet 28. évében, 2001-ben vizsgáltuk az eltérő N, P, K ellátottsági szintek és kombinációik hatását a réti csenkesz (Festuca pratensis) vezérnövényű, nyolckomponensű, pillangós nélküli gyepkeverék termésére, fejlődésére és N-felvételére. Termőhely talaja a szántott rétegben mintegy 3% humuszt, 3-5% CaCO3-ot és 20-22% agyagot tartalmazott, N és K elemekben közepesen, P és Zn elemekben gyengén ellátottnak minősült. A kísérlet 4N x 4P x 4K = 64 kezelést x 2 ismétlést = 128 parcellát foglalt magában. A talajvíz 13-15 m mélyen helyezkedik el, a terület aszályérzékeny. A v

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Komrokji, Rami S., Amy E. DeZern, Katrina Zell, et al. "Validation of International Working Group (IWG) Response Criteria in Higher-Risk Myelodysplastic Syndromes (MDS): A Report on Behalf of the MDS Clinical Research Consortium (MDS CRC)." Blood 126, no. 23 (2015): 909. http://dx.doi.org/10.1182/blood.v126.23.909.909.

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Introduction The primary goal for treatment of higher-risk MDS patients (pts) is to improve overall survival (OS) and delay acute myeloid leukemia (AML) evolution. The IWG 2006 response criteria are used in clinical trials and in clinical practice for assessing efficacy of MDS therapies. These criteria were originally proposed by an international group of experts based on available data and consensus. In an ad hoc landmark analysis of the AZA-001 study using the 2006 IWG criteria, pts who achieved hematological improvement (HI), complete response (CR), marrow CR (mCR), or partial response (PR)

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Metges, Jean-Philippe, Emon Elboudwarej, David Cunningham, et al. "Exploratory evaluation of baseline tumor biomarkers and their association with response and survival in patients with previously treated advanced gastric cancer treated with andecaliximab combined with nivolumab versus nivolumab." Journal of Clinical Oncology 37, no. 4_suppl (2019): 148. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.148.

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148 Background: Andecaliximab (ADX) is a monoclonal antibody that inhibits matrix metalloproteinase 9 (MMP9). Preclinical studies suggest that MMP9 inhibition relieves immune suppression and promotes T cell infiltration to potentiate checkpoint blockade. In the phase 2 study combining ADX with nivolumab (N) versus N monotherapy (NCT02864381), addition of ADX to N did not improve objective response rate, progression-free survival (PFS), or overall survival (OS). Methods: Archival tumor samples were collected from all patients (n = 141). CD8 and PD-L1 (28-8 DAKO) were assessed by immunohistochem

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Vose, Julie M., Ravi Pingali, Nina Wagner-Johnson, et al. "Lack Of Clinical Benefit For Routine Surveillance Imaging For Diffuse Large B-Cell Lymphoma In First Complete Remission." Blood 122, no. 21 (2013): 4303. http://dx.doi.org/10.1182/blood.v122.21.4303.4303.

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Abstract Background The use of routine surveillance imaging (RSI) for patients in first complete remission (CR1) following front-line rituximab (R) based anthracycline therapy remains controversial. We compared patients with diffuse large B-cell lymphoma (DLBCL) who received an R-CHOP or a similar regimen, obtained a CR and then were followed by either RSI or clinical surveillance (CS) in which scans were only performed for signs or symptoms. Methods Patients from three tertiary care center from 2001-2011, who achieved a CR1 with frontline R-CHOP or similar therapy for DLBCL, and had a minimum

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Haugeberg, G., A. Kavanaugh, and B. Michelsen. "AB0783 THE IMPACT OF SKIN ITCHING ON HEALTH RELATED QUALITY OF LIFE IN PSORIATIC ARTHRITIS OUTPATIENT CLINIC PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1689.1–1690. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1088.

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Background:In psoriatic arthritis (PsA) both skin and musculoskeletal involvement can contribute to reduce health related quality of life (HRQoL) (1). Although itch is considered an important symptom in psoriasis, less is known about its extent and potential impact on HRQoL in PsA.Objectives:The aim of the study was to assess the prevalence of itchy, sore, painful or stinging skin in PsA patients and also to explore the impact of these symptoms on overall HRQoL and skin related HRQoL.Methods:PsA patients were consecutively recruited from a rheumatology outpatient clinic. Data collection includ

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Almeida Moreno Santos, Rogerio, Gabriel Berlingieri Polho, Vinicius Cruz Parrela, et al. "Metastasis-directed treatment (MDT) for patients (pts) with non-clear cell renal cell carcinoma (nccRCC): Results from a matched 15-year retrospective cohort." Journal of Clinical Oncology 43, no. 5_suppl (2025): 497. https://doi.org/10.1200/jco.2025.43.5_suppl.497.

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497 Background: nccRCC represents a diverse group of diseases with variable clinicopathological features. We aimed to evaluate the impact of MDT on clinical outcomes of pts with nccRCC. Methods: We reviewed our institutional database (São Paulo State Cancer Institute, University of São Paulo) to identify pts with ICD-C64 (kidney cancer) with nccRCC. Electronic medical records were reviewed to register the clinical and pathological features. Histological subtypes were classified as per the 2022 World Health Organization classification. MDT was considered as any focal treatment (surgery or radia

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Ruiz, Maria Armila, David Shuey, Jin Han, et al. "Haptoglobin 1-1 Isoform Predicts Higher Serum Haptoglobin Concentration and Lower Multiorgan Failure Risk in Sickle Cell Disease." Blood 138, Supplement 1 (2021): 3095. http://dx.doi.org/10.1182/blood-2021-149697.

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Abstract Haptoglobin (HP) is the major scavenger of cell-free hemoglobin in circulation. When haptoglobin is depleted, cell-free hemoglobin can lead to organ damage through direct oxidative injury, upregulation of inflammatory pathways, and depletion of nitric oxide. A common polymorphism in HP gives rise to structurally and functionally distinct phenotypes: HP 1-1, HP 2-1, and HP 2-2. In people of African descent, the HP 1-1 and 2-1 phenotypes have been associated with higher serum HP concentrations compared to the HP 2-2 phenotype (PMID 10807979). In hemolytic diseases, such as sickle cell d

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Schulman, Sam, Henry Eriksson, Ajay Kakkar, et al. "Influence of Age and Renal Function on Efficacy and Safety of Dabigatran Versus Warfarin for the Treatment of Acute Venous Thromboembolism: A Pooled Analysis of RE-COVER™ and RE-COVER™ II." Blood 124, no. 21 (2014): 594. http://dx.doi.org/10.1182/blood.v124.21.594.594.

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Abstract Background: In the RE-COVER™ and RE-COVER™ II trials, dabigatran etexilate (DE) was as effective as warfarin (W) for prevention of recurrent venous thromboembolism (VTE) in patients with acute VTE, and was associated with a lower risk of bleeding. Objectives: Older patients and patients with renal impairment may be at greater risk of bleeding and/or VTE. In this post-hoc analysis of the pooled dataset from RE-COVER™ and RE-COVER™ II, we assessed rates of VTE recurrence and bleeding with DE and W in patients below and above 75 years according to renal function (normal, or mildly or mod

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Walsh, J. A., A. Ogdie, K. Michaud, et al. "AB0818 SKIN INVOLVEMENT IN PSORIATIC ARTHRITIS (PsA) - THE INCREMENTAL IMPACT OF PSORIASIS ON QUALITY OF LIFE, DISABILITY AND WORK PRODUCTIVITY: REAL-WORLD SURVEY IN US AND EUROPE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1711.2–1712. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5758.

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Background:PsA involves joint and skin symptom presentation that varies across patients. Differences in patients outcomes with joint only, and joint and skin involvement have not been extensively studied in a real-world setting.Objectives:To assess prevalence of joint only, and joint and skin disease in a real-world clinical setting, and to assess incremental impact of skin symptoms on quality of life (QoL), disability and work productivity.Methods:A cross-sectional survey in patients with PsA recruited by rheumatologists and dermatologists was conducted in France, Germany, Italy, Spain, UK an

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Duffy, Caitlyn, Elizabeth Dang, Zhou Yinmei, et al. "Safety and Feasibility of Blinatumomab As Frontline Therapy for Pediatric Patients with B-Acute Lymphoblastic Leukemia and Lymphoma: St. Jude Total Therapy Study XVII." Blood 144, Supplement 1 (2024): 4208. https://doi.org/10.1182/blood-2024-209284.

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Background Total Therapy Studies XV and XVI demonstrated that, for children with acute lymphoblastic leukemia (ALL), minimal residual disease (MRD) ≥ 0.01% at the end of induction (EOI) and/or high-risk (HR) genetic subtypes were associated with poorer outcomes. In Total Therapy Study XVII, children with ALL and lymphoblastic lymphoma (LLy) were treated with a precision medicine approach using flow cytometry-based MRD detection and next-generation sequencing-based genetic characterization. Blinatumomab, a bispecific T-cell engager, is indicated for treating B-ALL. This study evaluated the safe

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Douvali, Evdoxia, Menelaos Papoutselis, Emmanuil Spanoudakis, et al. "Safety and Efficacy of Azacitidine in Myelodysplastic Syndrome (MDS) Patients with Mild and Moderate Renal Impairment." Blood 120, no. 21 (2012): 1716. http://dx.doi.org/10.1182/blood.v120.21.1716.1716.

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Abstract Abstract 1716 Myelodysplastic syndrome patients with renal impairment (RI) were excluded for the approval trials of azacitidine, thus the optimal use of the latter in such patients is currently undefined. Only one single center, retrospective study addressed the efficacy and toxicity of azacytidine in patients with RI (Batty GN et al), but no comparative analysis between patients with or without RI has been performed yet. We retrospectively analyzed 42 MDS patients treated with azacitidine in a non-trial clinical setting. Patients were classified according to WHO as RAEB-II (n=18), AM

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Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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Kubesch, A., L. Grimm, K. Stratmann, et al. "P548 Drug Survival in Patients with Inflammatory Bowel disease: An observational study." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S517. http://dx.doi.org/10.1093/ecco-jcc/jjab076.669.

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Abstract Background Although the therapeutic array has significantly widened, over the past decades predicting treatment persistence in IBD patients is still a challenge. In this study we collected longitudinal data to determine drug survival on the medications currently available for IBD. Methods Patients treated in the IBD outpatient clinic of the Goethe University Hospital were retrospectively analyzed. Laboratory parameters and data on treatment adherence were collected via the electronic patient file. We investigated how many patients continued on the respective substances after the induc

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Economopoulou, Panagiota, Nikolaos Spiridon Spathas, George Papaxoinis, et al. "Clinical implications of hyperprogression with immune checkpoint inhibitors in patients with head and neck squamous cell carcinoma (HNSCC)." Journal of Clinical Oncology 37, no. 15_suppl (2019): 6034. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.6034.

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6034 Background: Hyperprogressive disease (HPD) refers to paradoxical acceleration of tumor growth kinetics (TGK) after initiation of treatment with anti- PD-1/PD- L1 agents and has been reported across tumor types in 4-29% of patients using different definitions. Preliminary data suggest that HPD might affect response to subsequent therapies. Methods: We compared TGK prior and TGK upon immunotherapy (IO) in 62 patients (pts) with recurrent/metastatic (R/M) HNSCC treated with PD-1/PD-L1 inhibitors. The TGK ratio (TGKR, ratio of tumor growth velocity before and upon treatment) was calculated. T

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Divya, Teja D., and Vardhani Viveka. "Influence of Gene Vac B vaccine on the abdominal muscle MDA in the immunostimulated male swiss albino mice." Biolife 4, no. 1 (2022): 68–73. https://doi.org/10.5281/zenodo.7309976.

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<strong>ABSTRACT</strong> Malondialdehyde (MDA) is a naturally occurring product of lipid peroxidation, initiated by free radicals (causing oxidative stress by reactive oxygen species - ROS). MDA is highly mutagenic and carcinogenic and plays a significant role in disease pathogenesis by disturbing the immune response and forms immune complexes that may be deposited in various tissues. This study is centralized on the immunostimulatory effect of Immunex DS (IDS) on the MDA level in abdominal muscle tissue of mice against Gene Vac B vaccine. Eight groups of male swiss albino mice (10 in each) w

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Horwitz, Steven M., James M. Foran, Michael Maris, et al. "Updates from Ongoing, First-in-Human Phase 1 Dose Escalation and Expansion Study of TTI-621, a Novel Biologic Targeting CD47, in Patients with Relapsed or Refractory Hematologic Malignancies." Blood 136, Supplement 1 (2020): 41–43. http://dx.doi.org/10.1182/blood-2020-136198.

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Background CD47 is an innate immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "do not eat" signal to suppress macrophage phagocytosis. Overexpression of CD47 can allow tumor cells to escape immune surveillance. TTI-621 (SIRPαFc) is a fusion protein consisting of the CD47 binding domain of human SIRPα linked to the Fc region of human IgG1, designed to enhance phagocytosis and antitumor activity by blocking the CD47-SIRPα interaction between malignant cells and macrophages, and engaging Fcγ receptors. Here we report updates from the first-in-human study of TTI-

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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