Academic literature on the topic '621.65.03, 532.5'

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Journal articles on the topic "621.65.03, 532.5"

1

Ohtake, Shigeki, Shuichi Miyawaki, Hiroyuki Fujita, et al. "Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: the JALSG AML201 Study." Blood 117, no. 8 (2011): 2358–65. http://dx.doi.org/10.1182/blood-2010-03-273243.

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Abstract We conducted a multi-institutional randomized study to determine whether high-dose daunorubicin would be as effective as standard-dose idarubicin in remission-induction therapy for newly diagnosed adult patients younger than 65 years of age with acute myeloid leukemia. Of 1064 patients registered, 1057 were evaluable. They were randomly assigned to receive either daunorubicin (50 mg/m2 daily for 5 days) or idarubicin (12 mg/m2 daily for 3 days) in combination with 100 mg/m2 of cytarabine by continuous infusion daily for 7 days as induction therapy. Complete remission was achieved in 4
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2

Martiasari, Linda Dewi, and Achsania Hendratmi. "Menilai Halal Awareness dan Lifestyle Terhadap Keputusan Menginap di Hotel Syariah." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 4 (2022): 523–33. http://dx.doi.org/10.20473/vol9iss20224pp523-533.

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ABSTRAK Penelitian ini dikembangkan untuk menganalisa faktor yang mempengaruhi keputusan menginap seorang konsumen muslim terhadap Hotel Syariah. Pengambilan data dilakukan pada tahun 2021 dengan 200 responden dengan menggunakan metode purposive sampling. Dari hasil analisa regresi berganda halal awareness dan lifestyle seorang konsumen muslim berpengaruh signifikan dengan keputusan menginap di Hotel Syariah. Dengan demikian, penelitian ini mengungkapkan pentingnya para pelaku bisnis Hotel Syariah untuk menyusun strategi yang sesuai dengan halal awareness dan lifestyle pasar sasaran seorang ko
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3

Silver, Richard T., Moshe Talpaz, Charles L. Sawyers, et al. "Four Years of Follow-Up of 1027 Patients with Late Chronic Phase (L-CP), Accelerated Phase (AP), or Blast Crisis (BC) Chronic Myeloid Leukemia (CML) Treated with Imatinib in Three Large Phase II Trials." Blood 104, no. 11 (2004): 23. http://dx.doi.org/10.1182/blood.v104.11.23.23.

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Abstract Background This report updates the results of 3 large phase II studies of the orally available BCR-ABL tyrosine kinase inhibitor imatinib for patients (pts) in AP, BC and late chronic phase (L-CP) CML failing prior interferon therapy (Kantarjan et al, ASH 2003; Talpaz et al, ASH 2003). Methods Between August 1999 and June 2000, 1027 pts were enrolled in phase II trials for CML in L-CP (n=532), AP (n=235) or BC (n=260). Pts in L-CP were treated with 400 mg/day and pts in AP or BC with either 400 or 600 mg/day. Dose escalation up to 800 mg/d was allowed in the late-chronic phase study.
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McArthur, Heather, Hanna Tukachinsky, Alexa Schrock, et al. "Abstract PO2-16-03: ESR1 genomic alterations (GAs) and coexistent putative resistance alterations in comprehensive genomic profiling (CGP) of metastatic breast cancer (MBC)." Cancer Research 84, no. 9_Supplement (2024): PO2–16–03—PO2–16–03. http://dx.doi.org/10.1158/1538-7445.sabcs23-po2-16-03.

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Abstract Background: ESR1 mutations (ESR1mut) are an established biomarker of endocrine therapy (ET) resistance in patients (pts) with hormone receptor positive (HR+) MBC. Moreover, ESR1mut acquired in response to standard-of-care ET now confer access to novel ET recently approved by health authorities. However, the nuanced genomic landscape beyond the simple presence or absence of ESR1mut may be critically important. We report on detailed ESR1 GAs detected by tissue and liquid biopsies (TBx, LBx) and examine the prevalence of co-occurring GAs in other genes reported to confer intrinsic or acq
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Tefferi, Ayalew, Paola Guglielmelli, Christy Finke, et al. "Integration of Mutations and Karyotype Towards a Genetics-Based Prognostic Scoring System (GPSS) for Primary Myelofibrosis." Blood 124, no. 21 (2014): 406. http://dx.doi.org/10.1182/blood.v124.21.406.406.

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Abstract Background : Current prognostication in primary myelofibrosis (PMF) utilizes international prognostic scoring systems that rely on clinical parameters that are sensitive to day-to-day variations and subjective interpretation. Recent studies in PMF have disclosed important prognostic information attached to additional cytogenetic details (Blood. 2011;118:4595) and somatic mutations, including CALR and ASXL1 (NEJM. 2013;369:2379; Leukemia. 2013;27:1861). Methods : PMF diagnosis and definition of blast transformation (BT) were according to World Health Organization criteria (Blood. 2009;
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Abuhadra, Nour, Karam Al-Issa, Aaron T. Gerds, et al. "BCOR and BCORL1 mutations in Myelodysplastic Syndromes (MDS): Clonal Architecture and Impact on Outcomes." Blood 128, no. 22 (2016): 4293. http://dx.doi.org/10.1182/blood.v128.22.4293.4293.

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Abstract Background Several recurrent somatic mutations have been identified in MDS and these mutations play an important role in disease pathophysiology and outcome. BCOR and BCORL1 are located on chromosome X and interact with histone deacetylases and other cell functions. The BCOR gene is mutated (BCORMUT) in 4-6% of MDS patients (pts) and is associated with poor outcome. BCORL1 mutations (BCORL1MUT ) are present in <1% of MDS pts with an unknown impact on OS. We investigated the clonal architecture of BCOR and BCORL1 in MDS and the impact of these mutations on clinical outcome. Methods
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Amorim, Mariana Barbosa de, and Sylvia Regina Pedrosa Maestrelli. "O isolamento docente e seus condicionantes no início da docência em ciências (Teacher isolation and its conditioning factors in beginning of teaching in science)." Revista Eletrônica de Educação 14 (October 9, 2020): 4241121. http://dx.doi.org/10.14244/198271994241.

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e4241121This work focuses on the beginning of teaching in science and more specifically on the issue of teacher isolation, considered one of the main challenges faced during professional induction. From a brief theoretical debate on the theme, based on authors who discuss the issues of teacher training, professional culture and teacher's work, and approaching perspectives of beginning science teachers from Florianópolis (Brazil) on the subject through narrative-reflective interviews, it was intended to identify which are the main factors that condition the isolation of these individuals. The i
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Rodrigues, Leandra Aparecida Mendes dos Santos, Mayara Lustosa de Oliveira Barbosa, and Cristiane Maria Ribeiro. "Documentos oficiais e legislações educacionais no combate às desigualdades raciais: estudo com base na PNAD (Official documents and educational legislation in the fight against racial inequalities: study based on PNAD)." Revista Eletrônica de Educação 15 (February 23, 2021): e4360011. http://dx.doi.org/10.14244/198271994360.

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e4360011The objective of this research was to analyze how official documents and educational legislation present the subject of ethnic-racial diversity, and also reflect on their impact on reality through the National Household Sample Survey (PNAD) data. To this end, we conducted an analysis of legislation and official documents created for Brazilian education, from 1988 to 2018, based on the Bardin Content Analysis technique. Subsequently, this analysis was compared with the data available in the PNAD to verify the impact of publications regarding 1) average years of study by color/race in th
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9

Evangelin, G., Horne Bertrand, M. Muthupandi, and William S. John. "VENOMOUS SALIVA OF NON-HAEMATOPHAGOUS REDUVIID BUGS (HETEROPTERA: REDUVIIDAE): A REVIEW." Biolife 2, no. 2 (2022): 615–26. https://doi.org/10.5281/zenodo.7214084.

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<strong>ABSTRACT</strong> While reduviids are a modestly well characterized group of insects, especially the blood sucking triatominae due to the medical implications of the Chagas disease, which is mainly transmitted by the infected bugs whose excrement contains <em>Trypanosoma cruzi </em>that enters the body through bruises or cuts in the skin of humans, their non-haematophagus counterparts are a forgotten lot and have not been thoroughly investigated. The venom in the saliva of the non-haematophagus reduviids has come into the spotlight in the last couple of decades due to the voracious pre
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Krause, Amanda J., Madeline Greytak, Alexander M. Kaizer, et al. "Diagnostic Yield of Ambulatory Reflux Monitoring Systems for Evaluation of Chronic Laryngeal Symptoms." American Journal of Gastroenterology, October 13, 2023. http://dx.doi.org/10.14309/ajg.0000000000002557.

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Introduction Among patients with chronic laryngeal symptoms, ambulatory reflux monitoring off acid suppression is recommended to evaluate for laryngopharyngeal reflux (LPR). However, reflux monitoring systems are diverse in configuration and monitoring capabilities, which presents a challenge in creating a diagnostic reference standard in these patients. This study aimed to compare diagnostic yield and performance between reflux monitoring systems in patients with chronic laryngeal symptoms. Methods This multicenter, international study of adult patients referred for evaluation of LPR over a 5
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