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Journal articles on the topic '’622”712” (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. III 2/4-Nitrophenoxides of Univalent Heavy Metals." Australian Journal of Chemistry 51, no. 8 (1998): 735. http://dx.doi.org/10.1071/c97100.

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Room-temperature single-crystal X-ray studies are recorded for 2- and 4-nitrophenoxide salts of silver(I) and thallium(I), M(2-np) and Tl(4-np) (anhydrous), and Ag(4-np).H2O. Ag(2-np) is monoclinic, P21/c, a 9·012(4), b 5·743(5), c 12·594(5) Å, β 104·34(4)°, Z = 4; conventional R on |F| was 0·042 for No 1378 independent ‘observed’ (I > 3σ(I)) reflections. Tl(2-np) is monoclinic, C2/c, a 27·250(3), b 3·712(1), c 15·147(3) Å, β 114·41(1)°, Z = 8, R 0·025 for No 1346. Ag(4-np).H2O is monoclinic, P21/a, a 5·613(6), b 13·191(7), c 9·844(5) Å, β 92·50(6)°, Z = 4, R 0 ·033 for No 622. Tl(4-np) is

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Rajadurai, Pathmanathan, Tatiana Semiglazova, Alinta Hegmane, et al. "Abstract P5-13-25: PIK3CA registry: A noninterventional, descriptive, retrospective cohort study of PIK3CA mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)." Cancer Research 82, no. 4_Supplement (2022): P5–13–25—P5–13–25. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-13-25.

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Abstract Introduction: PIK3CA mutations (mut) occur in ~40% of patients (pts) with HR+, HER2- ABC, and lead to phosphatidylinositol 3-kinase (PI3K) pathway hyperactivation, endocrine resistance, and poor survival in advanced disease. Alpelisib, an α-selective PI3K inhibitor and degrader, demonstrated efficacy in combination with fulvestrant in the Phase III SOLAR-1 trial in pts with PIK3CA-mut HR+, HER2- ABC. Notably, treatment benefit was not seen in pts without PIK3CA-mut tumors. Expert guidelines now recommend testing for PIK3CA mut at advanced diagnosis; however, data on PIK3CA mut prevale

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Bowmaker, Graham A., Effendy, Eban N. de Silva та Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXII Synthesis, Spectroscopy and Structural Systematics of Some 1 : 2 Binuclear Complexes of Silver(I) Halides with Triphenylstibine, [(Ph3Sb)2Ag(μ-X)2Ag(SbPh3)2], X = Cl, Br, I". Australian Journal of Chemistry 50, № 6 (1997): 641. http://dx.doi.org/10.1071/c96038.

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Syntheses and room-temperature single-crystal X-ray structural characterization of binuclear 1 : 2 adducts formed between silver(I) halides, AgX (X = Cl, Br, I), and triphenylstibine, SbPh3, are described. The three complexes are isomorphous, being triclinic, P-1, a ≈ 18·5, b ≈ 14·6, c ≈ 14·5 Å, α ≈ 62·5, β ≈ 74, γ ≈ 77°, Z = 2 centrosymmetric dimers. Conventional R on F were 0·043, 0·038 and 0·046 for 4984, 8479 and 4166 independent, ‘observed’ (I > 3σ(I)) reflections respectively. In [(Ph3b)2Ag(µ-X)2Ag(SbPh3)2], Ag–Sb range between 2·702(1) and 2·744(2) Å, lengthening slightly from chlori

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Blas, Andrea L., Qingyi Yu, Cuixia Chen, et al. "Enrichment of a papaya high-density genetic map with AFLP markers." Genome 52, no. 8 (2009): 716–25. http://dx.doi.org/10.1139/g09-043.

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A high-density genetic linkage map of papaya, previously developed using an F2 mapping population derived from the intraspecific cross AU9 × SunUp, was enriched with AFLP markers. The comprehensive genetic map presented here spans 945.2 cM and covers 9 major and 5 minor linkage groups containing 712 SSR, 277 AFLP, and 1 morphological markers. The average marker density for the 9 major linkage groups is 0.9 cM between adjacent markers, and the total number of gaps >5 cM was reduced from 48 to 27 in the current map. AFLPs generated by EcoRI/MseI primer combinations were distributed throughout

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Syahrul, Muhammad Nur, Fajriani, Takril, and Reski Fitriah. "Analisis Kesesuaian Kualitas Air Sungai Dalam Mendukung Kegiatan Budidaya Perikanan di Desa Batetangnga, Kecamatan Binuang, Provinsi Sulawesi Barat." SIGANUS: Journal of Fisheries and Marine Science 3, no. 1 (2021): 171–81. http://dx.doi.org/10.31605/siganus.v3i1.1210.

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Penelitian ini bertujuan untuk menganalisis kualitas air Sungai Batetangnga sebagai dasar kelayakan budidaya untuk usaha budidaya perikanan. Penelitian ini dilaksanakan pada bulan Juni hingga Agustus 2021, di Sungai Batetangnga, Polewali Mandar, Sulawesi Barat. Lokasi pengambilan sampel dilakukan di Muara sungai, Rawa Bangun, Salu pajaan dan Limbong Lopi. Pengukuran parameter fisik kimiawi meliputi suhu, pH, oksigen terlarut, arus, kecerahan, amoniak dan fosfat. Metode pengukuran berdasarkan American Public Health Association (APHA). Data diolah dan dianalisa secara deskriptif. Hasil penelitia

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Dunlop, Hayley, Evelyn Fitzpatrick, Kevin Kurti, et al. "Participation of Patients From Racial and Ethnic Minority Groups in Phase 1 Early Cancer Drug Development Trials in the US, 2000-2018." JAMA Network Open 5, no. 11 (2022): e2239884. http://dx.doi.org/10.1001/jamanetworkopen.2022.39884.

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ImportanceDespite federal initiatives encouraging the enrollment of individuals from racial and ethnic minority groups in US clinical trials, no studies to date have specifically examined demographic disparities among participants in phase 1 drug development trials for patients with metastatic cancer.ObjectiveTo assess trends in the enrollment of patients from racial and ethnic minority groups in US phase 1 therapeutic drug trials for metastatic cancer from 2000 to 2018.Design, Setting, and ParticipantsIn this cross-sectional study, ClinicalTrials.gov was queried in July 2021 to identify compl

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Pencic-Popovic, Biljana, Vera Celic, Zoran Cosic, et al. "Heart rate variability and increased risk for developing type 2 diabetes mellitus." Vojnosanitetski pregled 71, no. 12 (2014): 1109–15. http://dx.doi.org/10.2298/vsp1412109p.

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Background/Aim. To our knowledge there are no data about the relationship between elevated risk for developing type 2 diabetes mellitus (DM2) and altered cardiac autonomic function. The aim of this study was to evaluate the association between heart rate variability (HRV) and slightly increased risk for DM2. Methods. We evaluated 69 subjects (50.0 ? 14.4 years; 30 male) without DM2, coronary artery disease and arrhythmias. The subjects were divided into two groups according to the Finnish Diabetes Risk Score (FINDRISC): group I (n = 39) included subjects with 12 > FINDRISC ? 7; group II (n

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Effendy, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXVIII Synthesis and Structural Systematics of Some 1 : 3 Adducts of Silver(I) Compounds with Triphenylstibine, [(Ph3Sb)3AgX], X = Cl, I, SCN, NCS, CN, ONO2." Australian Journal of Chemistry 50, no. 6 (1997): 587. http://dx.doi.org/10.1071/c96035.

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The syntheses and room-temperature single-crystal X-ray structural characterization of 1 : 3 adducts formed between silver(I) (pseudo-) halides, AgX, and triphenylstibine, SbPh3, are described for X = Cl, I, SCN, NCS, CN, NO3 (1)-(6). The chloride, as its methanol solvate (1a), is isomorphous with the arsine analogue: triclinic, P-1, a 13·373(4), b 14·48(6), c 14·702(3) Å, α 83·49(3), β 87·76(2), γ 76·45(3)°; Z = 2, conventional R on F being 0·046 for No 5514 independent ‘observed’ reflections (I > 3σ(I )). A new form (1b) of the chloride has also been authenticated: monoclinic, P 21/c, a 1

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Oh, Joo Han, Joo Hyun Park, Hyeon Jang Jeong, and Sung-Min Rhee. "Comparing Clinical Outcomes After Subacromial Spacer Insertion Versus Other Reconstruction Methods in the Treatment of Irreparable Massive Rotator Cuff Tears." Orthopaedic Journal of Sports Medicine 7, no. 9 (2019): 232596711986960. http://dx.doi.org/10.1177/2325967119869600.

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Background: Previous studies on subacromial spacer (SAS) insertion have been limited to case series that did not compare the effectiveness of this technique with other techniques. Hypothesis: Outcomes after SAS insertion for the treatment of irreparable massive rotator cuff tears (IMRCTs) will be similar to those of other techniques. Study Design: Cohort study; Level of evidence, 3. Methods: This retrospective study was based on data collected from patients who underwent correction of IMRCTs between January 2010 and October 2017. Group 1 patients (n = 17) received SAS insertion with or without

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Harrowfield, Jack M., Raj Pal Sharma, Todd M. Shand, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. I 2-Nitrophenoxides of Group 1." Australian Journal of Chemistry 51, no. 8 (1998): 707. http://dx.doi.org/10.1071/c97098.

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Room-temperature, single-crystal X-ray studies are recorded for the variously hydrated Group 1 metal derivatives of 2-nitrophenol (2-npH = C6H5NO3). A provisional determination is reported for Li(2-np).½H2O, set as monoclinic, P21/c, a 3·535(3), b 15·06(1), c 24·42(2) Å, β 91·7(1)°, Z = 8, conventional R on F currently 0·18 for No 875 ‘observed’ (I > 3σ(I)) reflections. Na(2-np).H2O is monoclinic, C2/c, a 34 ·23(2), b 3·624(4), c 35·48(2) Å, β 91·24(4)°, Z = 24, R 0·060 for No 1371. Rb(2-np).½ H2O is monoclinic, C2/c (isomorphous with the previously determined potassium analogue), a 25·269(

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Lima-Silva, Adriano Eduardo, Rômulo Bertuzzi, Elen Dalquano, et al. "Influence of high- and low-carbohydrate diet following glycogen-depleting exercise on heart rate variability and plasma catecholamines." Applied Physiology, Nutrition, and Metabolism 35, no. 4 (2010): 541–47. http://dx.doi.org/10.1139/h10-043.

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The purpose of this study was to investigate the effects of a short-term low- or high-carbohydrate (CHO) diet consumed after exercise on sympathetic nervous system activity. Twelve healthy males underwent a progressive incremental test; a control measurement of plasma catecholamines and heart rate variability (HRV); an exercise protocol to reduce endogenous CHO stores; a low- or high-CHO diet (counterbalanced order) consumed for 2 days, beginning immediately after the exercise protocol; and a second resting plasma catecholamine and HRV measurement. The exercise and diet protocols and the secon

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Tsur, Avishai M., Inbal Akavian, Estela Derazne, et al. "Adolescent Blood Pressure and the Risk for Early Kidney Damage in Young Adulthood." Hypertension 79, no. 5 (2022): 974–83. http://dx.doi.org/10.1161/hypertensionaha.121.18748.

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Background: Recent guidelines classified blood pressure above 130/80 mm Hg as hypertension. However, outcome data were lacking. Objective: To determine the association between blood pressure in adolescence and the risk for early kidney damage in young adulthood. Methods: In this nationwide cohort study, we included 629 168 adolescents aged 16 to 20 who underwent medical examinations before mandatory military service in Israel. We excluded 30 466 adolescents with kidney pathology, hypertension, or missing blood pressure or anthropometric data at study entry. Blood pressure measurements at study

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13

Jayaprakash, Priyamvada, Meghan Rice, Krithikaa Rajkumar Bhanu, et al. "622 Disrupted oxygen supply and tumor hyper- oxygen consumption contribute independently to prostate cancer immune privilege." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A652. http://dx.doi.org/10.1136/jitc-2021-sitc2021.622.

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BackgroundDespite the success of immunotherapy in immune-infiltrated ”hot” tumors like melanoma, ”cold” tumors like prostate cancer remain unresponsive [1,2,3]. We find that these tumors harbor regions of hypoxia that act as islands of immune privilege that exclude T cells, while retaining immunosuppressive myeloid cells. Targeting hypoxia using the hypoxia-activated prodrug, TH-302 (Evofosfamide) reduced hypoxic regions and co-operated with immune checkpoint blockade (anti-CTLA-4+anti PD-1) to drive tumor regression in transplantable and spontaneous murine prostate tumors [4]. In a Phase I cl

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Li, Weiming, Yingxue Li, Zhiyong Zhang, et al. "Predictive Nomogram of RAGE Genetic Polymorphisms and Metabolic Risk Factors for Myocardial Infarction Risk in a Han Chinese Population." Angiology 68, no. 10 (2017): 877–83. http://dx.doi.org/10.1177/0003319717696622.

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We investigated the association of 4 well-characterized polymorphisms in receptor for the advanced glycation end-product ( RAGE) gene with myocardial infarction (MI) risk and the changes in metabolic risk factors among 717/612 patients/controls, with the aim of constructing a predictive nomogram. The genotype/allele distributions differed significantly between the 2 groups for T-429C ( Pgenotype/allele = .004/.001) and G1704T ( P < .001/.001). T-429C was significantly associated with MI risk, especially under a recessive model (adjusted odds ratio: 2.24, 95% confidence interval: 1.33-3.79,

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Rose, Braden D., Vida Bitarafan, Peyman Rezaie, Penelope C. E. Fitzgerald, Michael Horowitz, and Christine Feinle-Bisset. "Comparative Effects of Intragastric and Intraduodenal Administration of Quinine on the Plasma Glucose Response to a Mixed-Nutrient Drink in Healthy Men: Relations with Glucoregulatory Hormones and Gastric Emptying." Journal of Nutrition 151, no. 6 (2021): 1453–61. http://dx.doi.org/10.1093/jn/nxab020.

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ABSTRACT Background In preclinical studies, bitter compounds, including quinine, stimulate secretion of glucoregulatory hormones [e.g., glucagon-like peptide-1 (GLP-1)] and slow gastric emptying, both key determinants of postprandial glycemia. A greater density of bitter-taste receptors has been reported in the duodenum than the stomach. Thus, intraduodenal (ID) delivery may be more effective in stimulating GI functions to lower postprandial glucose. Objective We compared effects of intragastric (IG) and ID quinine [as quinine hydrochloride (QHCl)] administration on the plasma glucose response

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Costa, Ricardo J. S., Atlanta Miall, Anthony Khoo, et al. "Gut-training: the impact of two weeks repetitive gut-challenge during exercise on gastrointestinal status, glucose availability, fuel kinetics, and running performance." Applied Physiology, Nutrition, and Metabolism 42, no. 5 (2017): 547–57. http://dx.doi.org/10.1139/apnm-2016-0453.

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Due to gastrointestinal tract adaptability, the study aimed to determine the impact of gut-training protocol over 2 weeks on gastrointestinal status, blood glucose availability, fuel kinetics, and running performance. Endurance runners (n = 25) performed a gut-challenge trial (GC1), consisting of 2 h running exercise at 60% V̇O2maxwhilst consuming gel-discs containing 30 g carbohydrates (2:1 glucose/fructose, 10% w/v) every 20 min and a 1 h distance test. Participants were then randomly assigned to a carbohydrate gel-disc (CHO-S), carbohydrate food (CHO-F), or placebo (PLA) gut-training group

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Gogate, Anagha, Amanda Crosbie, Trong Kim Le, Ying Zhang, Rolee Das, and Catherine Davis. "Abstract P3-12-15: Clinical characteristics, treatment patterns, and survival outcomes in women with early triple-negative (TN) or hormone receptor-positive/human epidermal growth factor receptor-2 negative (HR+/HER2−) breast cancer (BC) in the real-world (RW) setting." Cancer Research 82, no. 4_Supplement (2022): P3–12–15—P3–12–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-12-15.

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Abstract Background: BC remains the most commonly diagnosed cancer for women. TNBC is an aggressive form with a poorer prognosis compared with other subtypes. Neoadjuvant therapy (NAT) is the standard-of-care approach to shrink tumors in the breast and axilla and to improve patient outcomes. Few RW studies exist of US patients with early BC (eBC); this study aimed to describe clinical parameters by receipt of systemic therapy and to assess overall survival (OS) and progression-free survival (PFS) after NAT and adjuvant therapy (AT) in women with early HR+/HER2− or TNBC using RW evidence in the

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Pannala, Sravan, Everardo Olide, Rafid Mollah, et al. "An Experimental Correlation of Degradation with Cell Reversible and Irreversible Expansion Measurement in Pouch Cells." ECS Meeting Abstracts MA2023-01, no. 2 (2023): 554. http://dx.doi.org/10.1149/ma2023-012554mtgabs.

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Lithium-ion batteries are used widely in portable devices and play an increasingly significant role in transportation and grid storage. These batteries degrade when they undergo charging and discharging and also when they are stored (calendar aging). The rate of this degradation depends on how the batteries are used and under what conditions. As the battery is cycled, its internal impedance and individual electrode capacities change, causing a change in its electrical performance. In addition, changes in the reversible and irreversible expansion of the cell are also observed. Of particular con

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Dias, L. P., P. M. S. Rosa, A. J. R. Camargo, R. V. Serapião, L. S. A. Camargo, and C. S. Oliveira. "134 FOLLICULAR DYNAMICS OF Gyr AND HOLSTEIN OOCYTE DONORS KEPT UNDER TROPICAL CONDITIONS." Reproduction, Fertility and Development 28, no. 2 (2016): 197. http://dx.doi.org/10.1071/rdv28n2ab134.

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Bovine in vitro production is highly relevant for dairy systems in Brazil, and the main breeds used as oocyte donors are Gyr (G) and Holstein (H). This study aimed to evaluate the ovarian follicular dynamics of G and H oocyte donors kept under tropical conditions to detect differences that could guide improvement of follicular wave synchronization protocols for ovum pickup. Fourteen cyclic cows (6 H and 8 G), assessed twice each (after a 14-day interval), had their oestrus cycle synchronized by the use of 1.0 g of progesterone via intravaginal device (Ourofino, Brazil) and administration of 2

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Hoe, Francis M., Jeanne A. Darbinian, Louise C. Greenspan, and Joan C. Lo. "Hemoglobin A_1c and Type 2 Diabetes Incidence Among Adolescents With Overweight and Obesity." JAMA Network Open 7, no. 1 (2024): e2351322. http://dx.doi.org/10.1001/jamanetworkopen.2023.51322.

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ImportanceWith the increase in prediabetes among adolescents with overweight and obesity, identifying those at highest risk for type 2 diabetes (T2D) can support prevention strategies.ObjectiveTo assess T2D risk by hemoglobin A1c (HbA1c) levels among adolescents with overweight and obesity.Design, Setting, and ParticipantsThis retrospective cohort study was conducted using data for January 1, 2010, to December 31, 2019, from a large California health care system. The study population comprised adolescents aged 10 to 17 years who had a body mass index (BMI; calculated as weight in kilograms div

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Erdes, Sh F., D. G. Rumyantseva, E. M. Agafonova, M. M. Urumova, A. S. Starkova, and S. O. Krasnenko. "A case of effective use of interleukin 6 inhibitors in patients with ankylosing spondylitis with secondary amyloidosis." Modern Rheumatology Journal 15, no. 4 (2021): 38–42. http://dx.doi.org/10.14412/1996-7012-2021-4-38-42.

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Ineffectiveness of interleukin 6 inhibitors (iIL6), tocilizumab (TCZ) and sarilimumab in ankylosing spondylitis (AS) was shown in randomized clinical trials. However, there is ample evidence that IL6 is actively involved in the pathogenesis of this disease. In addition, the efficacy of iIL6 in patients with secondary AA-amyloidosis was established.Objective: to analyze the results of TCZ administration in AS, complicated by secondary AA-amyloidosis.Patients and methods. The analysis included 6 patients with AS with secondary AA-amyloidosis. All patients were HLA-B27 positive male. The average

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Gomes, Marília B., Milena O. Portavales, André M. Faria, Karla R. Guerra, Edna F. da Cunha, and Eliete Leão da S. Clemente. "Variabilidade intra-individual do controle glicêmico em pacientes com diabetes tipo 1." Arquivos Brasileiros de Endocrinologia & Metabologia 47, no. 5 (2003): 578–83. http://dx.doi.org/10.1590/s0004-27302003000500012.

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OBJETIVO: Avaliar a variabilidade do controle glicêmico em pacientes com diabetes tipo1 (DM1) em acompanhamento ambulatorial. PACIENTES E MÉTODOS: Foram estudados 100 pacientes com DM1 (55 do sexo feminino), com idade de 18,6±9 anos, idade de diagnóstico de 12 anos (1-35) e duração do diabetes de 5 anos (0,09-40), com tempo de seguimento de 4,3 anos (2-8,5). A HbA1c foi determinada por cromatografia de troca iônica (valor de referência: 2,4-6,2%). RESULTADOS: Foram analisados os dados de 94 pacientes. A HbA1c inicial e final foi de 7,6±1,8% e 8,7±2,1, com aumento absoluto de 1,1% (-7; 7,2) e a

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Liu, Jennifer Z., Catherine R. Counts, Christopher J. Drucker, et al. "Acute SARS-CoV-2 Infection and Incidence and Outcomes of Out-of-Hospital Cardiac Arrest." JAMA Network Open 6, no. 10 (2023): e2336992. http://dx.doi.org/10.1001/jamanetworkopen.2023.36992.

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ImportanceLittle is known about how COVID-19 affects the incidence or outcomes of out-of-hospital cardiac arrest (OHCA), and it is possible that more generalized factors beyond SARS-CoV-2 infection are primarily responsible for changes in OHCA incidence and outcome.ObjectiveTo assess whether COVID-19 is associated with OHCA incidence and outcomes.Design, Setting, and ParticipantsThis retrospective cohort study was conducted in Seattle and King County, Washington. Participants included persons aged 18 years or older with nontraumatic OHCA attended by emergency medical services (EMS) between Jan

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Агарков, Н. М., Н. В. Попова, Е. Н. Коровин та М. Л. Курзин. "СВЯЗЬ ЭКССУДАТИВНОЙ ФОРМЫ ВОЗРАСТНОЙ МАКУЛЯРНОЙ ДЕГЕНЕРАЦИИ С ХЕМОКИНАМИ СЛЁЗНОЙ ЖИДКОСТИ У ПОЖИЛЫХ ПАЦИЕНТОВ". Успехи геронтологии 37, № 4 (2024): 430–35. http://dx.doi.org/10.34922/ae.2024.37.4.014.

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Возрастная макулярная дегенерация (ВМД), наряду с другими возраст-ассоциированными офтальмонозологическими формами, выступает существенной причиной утраты зрительных функций у пожилых людей, но связь экссудативной формы ВМД с хемокинами слёзной жидкости недостаточна изучена. Цель работы — изучение связи экссудативной формы ВМД с хемокинами слёзной жидкости у пожилых пациентов. Было изучено содержание хемокинов в слёзной жидкости у 92 пациентов 60–74 лет (184 глаза) с экссудативной формой ВМД и у 84 пациентов 60–74 лет (168 глаз) без офтальмопатологии на сертифицированном приборе «MAGRIX» (США)

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Burress, Lainy A., and John M. Clements. "Racial and Ethnic Disparities in Type 2 Diabetes Complications and In-Hospital Mortality in the United States: A Retrospective Cohort Study." Diabetology 6, no. 3 (2025): 15. https://doi.org/10.3390/diabetology6030015.

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Objectives: To describe the association of race with type 2 diabetes complications and determine if differences in rates of complications exist between racial/ethnic groups of adult type 2 diabetes patients in the United States. Additionally, we model the odds of in-hospital patient mortality across racial/ethnic groups. Methods: A retrospective cohort study was conducted using data from the 2018 National Inpatient Sample of Healthcare Cost and Utilization Project, including 97,314 unweighted and 486,500 weighted adults with type 2 diabetes. Chi-square analysis was used to determine the associ

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Kuznetsova, K. V., G. R. Bikbaeva, E. M. Sukhinina, et al. "Computed tomography angiography or invasive coronary angiography in patients with lowto intermediate risk acute coronary syndrome — a single-center study." Russian Journal of Cardiology 29, no. 1S (2024): 5702. http://dx.doi.org/10.15829/1560-4071-2024-5702.

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Aim. To evaluate the strategy of using coronary computed tomography angiography (CCTA) in patients with low-to-intermediate risk of non-ST segment elevation acute coronary syndrome (NSTE-ACS) in relation to early (in-hospital) and long-term prognosis in comparison with standard management tactics.Material and methods. The study included 259 patients (men (M), 47,9%, mean age, 62,2±9,4 years). Patients in group 1 (n=148 people, M 46,6%, mean age 61,99±9,92 years) underwent CCTA to assess coronary involvement, and patients in group 2 (n=111 people, M 49,5%, mean age 62,4±8,6 years) — invasive co

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Zilberberg, Marya D., Andrew F. Shorr, Scott T. Micek, et al. "Epidemiology and Outcomes of Hospitalizations with Complicated Skin and Skin-Structure Infections: Implications of Healthcare-Associated Infection Risk Factors." Infection Control & Hospital Epidemiology 30, no. 12 (2009): 1203–10. http://dx.doi.org/10.1086/648083.

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Objective.Healthcare-associated infections are likely to be caused by drug-resistant and possibly mixed organisms and to be treated with inappropriate antibiotics. Because prompt appropriate treatment is associated with better outcomes, we studied the epidemiology of healthcare-associated complicated skin and skin-structure infections (cSSSIs).Patients.Persons hospitalized with cSSSI and a positive culture result.Methods.We conducted a single-center retrospective cohort study from April 2006 through December 2007. We differentiated healthcare-associated from community-acquired cSSSIs by at lea

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Gabriels, L., P. Cosyns, and B. Nuttin. "Differential Impact of Deep Brain Stimulation or Anterior Capsulotomy on General Functioning, Personality Features and Quality of Life in OCD." European Psychiatry 26, S2 (2011): 1140. http://dx.doi.org/10.1016/s0924-9338(11)72845-0.

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IntroductionResearch on deep brain stimulation (DBS) for treatment refractory obsessive-compulsive disorder (OCD) shows promising effects on symptoms severity.ObjectivesTo compare outcomes between DBS and bilateral capsulotomy on general functioning, personality traits and quality of life.MethodsConsecutive patients with severe and treatment refractory OCD underwent DBS in the anterior limb of the internal capsule (DBS; n = 14) or anterior capsulotomy (CAPS; n = 14). They were tested before surgery (baseline-BL) and after a mean follow-up time (FU) of 19 months (range 14-31 months). Changes in

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Dreo, B., B. Prietl, S. Kofler, et al. "AB0019 RITUXIMAB TREATMENT DOES NOT ALTER EXPRESSION OF CO-STIMULATION MARKER CD19 ON B CELLS IN SYSTEMIC SCLEROSIS PATIENTS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1144.2–1145. http://dx.doi.org/10.1136/annrheumdis-2022-eular.768.

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BackgroundCD19 is a membrane glycoprotein interacting with different surface molecules like the B cell receptor (BCR) and is crucial for antigen-independent development as well as immunoglobulin-induced activation of B cells.[1] Alterations in this signalling pathway can incline autoantibody production and systemic autoimmunity in humans. Rituximab (RTX), a CD20 antagonist appears to be an effective candidate in the treatment of different autoimmune diseases that are partly driven by autoreactive B cells, such as systemic sclerosis (SSc).[2] It has been speculated that RTX might work not only

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Powell, Danielle, Wuyang Zhang, and Nicholas Reed. "EFFECT OF AWARENESS OF HEARING LOSS AMONG CARE RECIPIENTS ON ATTRIBUTES OF CARE PROVIDED: A NATIONAL STUDY." Innovation in Aging 8, Supplement_1 (2024): 778. https://doi.org/10.1093/geroni/igae098.2529.

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Abstract Hearing loss (HL) is prevalent among older adults and may result in caregiving challenges due to communication barriers. This study aims to investigate whether care recipients’ awareness of HL is associated with attributes of care. Using data from Round 12 (2022) of the linked National Health and Aging Trends Study (NHATS) and National Study on Caregiving (NSOC), a sample of 1,133 (Mean age: 62±15 years; Female: 68%) caregivers assisting 713 older adults (Mean age: 83±8 years; Female: 63%; White: 63%) with audiometric HL was derived. From care recipients’ self-reported hearing difficu

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Witzig, Thomas E., Julie M. Vose, Pier Luigi Zinzani, et al. "Durable Responses After Lenalidomide Oral Monotherapy in Patients with Relapsed or Refractory (R/R) Aggressive Non-Hodgkin's Lymphoma (a-NHL): Results From An International Phase 2 Study (CC-5013-NHL-003)." Blood 114, no. 22 (2009): 1676. http://dx.doi.org/10.1182/blood.v114.22.1676.1676.

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Abstract Abstract 1676 Poster Board I-702 Introduction Aggressive NHL (a-NHL) comprises a heterogeneous group of B-cell malignancies, each characterized by a unique histology and molecular markers. The most common types are diffuse large B-cell lymphoma (DLBCL), transformed lymphoma (TL), follicular grade III (FL-III), and mantle cell lymphoma (MCL). Although initial therapy can be effective, up to 40% of patients with DLBCL either fail to respond or relapse after initial therapy (Habermann TM et al JCO 2006), and relapses are likely among patients with MCL. For such patients survival outcomes

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Noronha, Jarin, Shalaka Joshi, Rohini Hawaldar, et al. "Sterilization Rate of the Axilla After Neoadjuvant Chemotherapy: The Scope for Conservative Surgery." JCO Global Oncology, no. 6 (September 2020): 1184–91. http://dx.doi.org/10.1200/go.20.00195.

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PURPOSE The role of axillary conservation after neoadjuvant chemotherapy (NACT) is debatable. We routinely carry out complete axillary lymph node dissection (ALND). This study was conducted to understand the pathologic axillary complete response (pAxCR) after NACT. MATERIALS AND METHODS We evaluated a prospective database of patients with breast cancer who underwent surgery after NACT in the year 2017 at our institution. NACT was administered to downstage locally advanced breast cancer or facilitate breast-conservation surgery. RESULTS Of 793 patients who underwent surgery after NACT, 97(12.2%

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Fuchylo, Yaroslav, та Yaroslav Kirilko. "Продуктивність енергетичних плантацій тополі на малогумусних чорноземах Правобережного Лісостепу України". Наукові праці Лісівничої академії наук України, № 25 (23 листопада 2023): 122–27. http://dx.doi.org/10.15421/412309.

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Наведено результати чотирирічних досліджень росту тополі сорту 'Robusta' в енергетичних плантаціях на малогумусних чорноземах Правобережного Лісостепу України, створених однорічними здерев’янілими живцями завдовжки 25 см і діаметром 0,8-1,0 см. Схеми садіння – 2,0 × 0,8 м та 2,0 × 0,9 м. Після першого року дерева на обох ділянках мали середню висоту 1,6 м. Впродовж другого року їхній приріст за висотою становив у рідшого варіанту 2,0±0,05 м, у густішого – 2,1±0,05 м. Впродовж третього вегетаційного періоду приріст за висотою становив відповідно 3,1 та 3,0 м, а середня висота рослин склала 6,8

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von Wyl, Viktor, Marc Höglinger, Chloé Sieber, et al. "Drivers of Acceptance of COVID-19 Proximity Tracing Apps in Switzerland: Panel Survey Analysis." JMIR Public Health and Surveillance 7, no. 1 (2021): e25701. http://dx.doi.org/10.2196/25701.

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Background Digital proximity tracing apps have been released to mitigate the transmission of SARS-CoV-2, the virus known to cause COVID-19. However, it remains unclear how the acceptance and uptake of these apps can be improved. Objective This study aimed to investigate the coverage of the SwissCovid app and the reasons for its nonuse in Switzerland during a period of increasing incidence of COVID-19 cases. Methods We collected data between September 28 and October 8, 2020, via a nationwide online panel survey (COVID-19 Social Monitor, N=1511). We examined sociodemographic and behavioral facto

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Torres Júnior, J. R. S., M. F. A. Pires, W. F. Sá, et al. "318 EFFECT OF MATERNAL HEAT STRESS ON OOCYTE QUALITY AND IN VITRO COMPETENCE IN BOS INDICUS CATTLE." Reproduction, Fertility and Development 19, no. 1 (2007): 274. http://dx.doi.org/10.1071/rdv19n1ab318.

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High temperatures can be harmful to the competence of cumulus–oocyte complexes and to embryo development (Al-Katanani et al. 2002 J. Dairy Sci. 85, 390–396). The aim of this study was to evaluate the effect of maternal heat stress on in vitro embryo yield. Ten multiparous nonlactating Gir (Bos indicus) cows were kept in tie stalls for an adaptive period of 28 days [pre-heat-stress period (PRE-HS)/Days -28 to -1]. Cows were subjected to 2 OPU (ovum pickup) sessions (Days -14 and -7). In the heat-stress period (HS; Days 0 to 28), cows were divided into control (C: n = 5) and heat-stressed (HS: n

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Popov, V. V., O. O. Bolshak, V. J. Boukarim, R. M. Vitovskiy, and Y. V. Bakhovska. "Anterior Mitral Leaflet Translocation during Correction of Combined Mitral-Aortic Valve Disease." Ukrainian journal of cardiovascular surgery, no. 4 (41) (December 16, 2020): 40–44. http://dx.doi.org/10.30702/ujcvs/20.4112/054040-044/08097.

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The aim. To study the possibilities of techniques for preserving left ventricular (LV) contractility during mitral valve replacement (MVR) and correction of combined mitral-aortic valve disease (CMAVD). The analyzed group included 257 patients with CMAVD who were undergoing surgical treatment at the Institute. In 97 patients, MVR was performed with translocation of the chordae of the anterior leaflet muscles in combination with complete preservation of the posterior leaflet. Of the 97 operated patients, 2 (2.1%) died at the hospital stage (within 30 days after the operation). Inotropic support

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Greenberg, P., G. Dine, A. Ganser, et al. "Deferasirox (Exjade®, ICL670) Demonstrates Dose-Related Effects on Body Iron Levels Related to Transfusional Iron Intake in Transfusion-Dependent Anemia." Blood 106, no. 11 (2005): 2694. http://dx.doi.org/10.1182/blood.v106.11.2694.2694.

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Abstract Iron overload, a potentially serious consequence of multiple blood transfusions, can be effectively managed with chelation therapy. Deferasirox, an investigational once-daily oral chelator, has been evaluated in a 1 year study of iron-overloaded adult and pediatric patients (n=184) with transfusion-dependent anemia including β-thalassemia, myelodysplastic syndromes (MDS) and Diamond-Blackfan anemia (DBA). Patients were stratified into four daily dose groups (5, 10, 20 and 30 mg/kg) according to baseline liver iron concentration (LIC; 2–3, &gt;3–7, &gt;7–14 and &gt;14 mg Fe

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Meißner, Y., N. Costedoat-Chalumeau, F. Förger, et al. "FRI0558 PREGNANCY OUTCOMES IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS – A FIRST JOINT ANALYSIS OF A EUROPEAN COLLABORATION OF PREGNANCY REGISTERS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 881–82. http://dx.doi.org/10.1136/annrheumdis-2020-eular.579.

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Background:Axial spondyloarthritis (axSpA) can affect women in their childbearing age. But data on pregnancy in axSpA patients are mainly retrospective and highly heterogeneous [1].Objectives:The aim of this analysis was to investigate pregnancy outcomes and health of live born children in women with axSpA in four prospective cohort studies.Methods:Data of European pregnancy registries that collaborate in the European Network of Pregnancy Registries in Rheumatology (EuNeP) were analysed: EGR2 (France), RePreg (Switzerland), RevNatus (Norway) and Rhekiss (Germany). Eligible women had a diagnosi

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Kádár, Imre, and Zoltán Győri. "Műtrágyázás hatása a telepített gyep aminosav tartalmára és hozamára 5." Gyepgazdálkodási Közlemények 3, no. 1-2 (2021): 11–20. http://dx.doi.org/10.55725/gygk/2005/3/1-2/10434.

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Egy műtrágyázási kísérlet 28. évében, 2001-ben vizsgáltuk az eltérő N, P és K ellátottsági szintek és kombinációik hatását a réti csenkesz vezérnövényű nyolckomponensű pillangós nélküli gyepkeverék aminosav tartalmára és hozamára. A termőhely talaja a szántott rétegben mintegy 3% humuszt, 3-5% CaCO3-ot és 20-22% agyagot tartalmazott, N és K elemekben közepesen, P és Zn elemekben gyengén ellátottnak minősült. A kísérlet 4N x 4P x 4K = 64 kezelést x 2 ismétlést = 128 parcellát foglalt magában. A talajvíz 13-15 m mélyen helyezkedik el, a terület aszályérzékeny. A vizsgált 2001. évben kielégítő, 6

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Martynova, A., T. Popkova, A. Aleksankin, and E. Gerasimova. "AB0068 B- AND T- LYMPHOCYTE SUBSETS IN PATIENTS WITH EARLY AND PROGRESSED RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1064.2–1065. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3816.

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Background:Role of B- and T- lymphocytes is well established in pathogenesis of rheumatoid arthritis (RA). Self-containing activation of B-cells in ectopic germinative centers is followed by auto-activation of T-lymphocytes while T-cells themselves are antigen-presenting cells for B-lymphocytes [1-2]. As these processes continue with the duration of RA, different subsets of B- and T-cell might be prevalent at different stages of RA.Objectives:Evaluate differences in dynamics of B- and T- cell subsets in early and progressed RA.Methods:53 patients with diagnosed RA(ACR/EULAR 2010 criteria) were

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Palomares-Pérez, Martín, Manuel Bravo-Nuñez, and Hugo C. Arredondo-Bernal. "LIBERACIÓN DE Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) Y MANEJO PARA EL CONTROL DE Melanaphis sacchari (Zehntner) (Hemiptera: Aphididae) EN CULTIVO DE SORGO." Agrociencia 54, no. 3 (2020): 435–44. http://dx.doi.org/10.47163/agrociencia.v54i3.1917.

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Melanaphis sacchari es una plaga de reciente introducción en México y puede causar hasta 100% de pérdidas al cultivo de sorgo (Sorghum vulgare). La estrategia del manejo integrado de este pulgón incluye el uso de enemigos naturales, por tal motivo, para colaborar en la problemática ocasionada por este insecto, se planteó el objetivo de evaluar el efecto de la liberación de Chrysoperla externa sobre la población de M. sacchari en el cultivo de sorgo en ambiente natural de cultivo e invernadero. La hipótesis es que la densidad poblacional de M. sacchari y el número de plantas de sorgo infestadas

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Joh, Jae Won, Angel Callejas, Wendy Wong, Harvey Joel Cohen, Kari Nadeau, and Michael Jeng. "Role of Fas/FasL Pathway in Pediatric Idiopathic Neutropenia." Blood 110, no. 11 (2007): 3291. http://dx.doi.org/10.1182/blood.v110.11.3291.3291.

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Abstract Idiopathic neutropenia in children is marked by low neutrophil counts (<1500/ul) circulating in the peripheral blood in patients whose disease spontaneously develops unrelated to drugs, cancers, specific antibodies, or known genetic deficiencies. Neutrophils, PBMCs and plasma were purified/obtained from 24 subjects (n=17 acute and n=7 chronic) with idiopathic neutropenia, aged 3 months to 11 yrs. After screening a number of cytokines (IL-2, IL-4 IL-6, IL-8, IL-10, IFN-γ, TNF-α), growth factors (GCSF), cell death factors (Fas, FasL, Granzymes/Perforin), and chemokines (CCL5, XCL1, X

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Zhao, Jingxuan, Ilana Graetz, David H. Howard, et al. "Associations of Medicaid expansion with stage at diagnosis, timely initiation and receipt of guideline-concordant treatment, and survival among individuals newly diagnosed with non-small cell lung cancer." JCO Oncology Practice 20, no. 10_suppl (2024): 47. http://dx.doi.org/10.1200/op.2024.20.10_suppl.47.

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47 Background: Medicaid expansion under the Patient Protection and Affordable Care Act improved health insurance coverage among patients with cancer. Individuals with non-small cell lung cancer (NSCLC) may benefit from Medicaid expansion throughout the cancer control continuum. This study examined the associations of Medicaid expansion with stage at disease diagnosis, timely initiation and receipt of guideline-concordant treatment, and five-year overall survival among individuals with NSCLC. Methods: We identified individuals newly diagnosed at age 18-64 with stages I-IV first primary NSCLC be

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Chi, Yihebali, Yongqian Shu, Yi Ba, et al. "The efficacy and safety of anlotinib in refractory colorectal cancer: A double-blinded, placebo controlled, randomized phase III ALTER0703 trial." Journal of Clinical Oncology 39, no. 3_suppl (2021): 65. http://dx.doi.org/10.1200/jco.2021.39.3_suppl.65.

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65 Background: The efficacy of late line treatments for metastatic colorectal cancer (mCRC) is still limited. Antiangiogenic therapy is one of standard treatments in mCRC. Anlotinib is a multitarget tyrosine kinase inhibitor, mainly targets VEGFR1-3. This phase III trial was conducted to evaluate anti-tumor efficacy and safety of anlotinib monotherapy in refractory mCRC. Methods: Aged 18 years or older mCRC patients were enrolled in 33 Chinese hospitals. They had received at least 2 lines of chemotherapy based treatments; had ECOG PS 0-1and adequate bone marrow, liver and renal function. Enrol

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Abu-Khalaf, Maysa, Fnu Nikita, Ayako Shimada, et al. "Abstract P4-11-32: Change in body mass index in breast cancer survivors." Cancer Research 82, no. 4_Supplement (2022): P4–11–32—P4–11–32. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-11-32.

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Abstract Background: Obesity is associated with an increased risk of breast cancer recurrence and poor survival. Obesity rate in adults in the city of Philadelphia is high, with non-Hispanic blacks and Hispanics having the highest rates. We sought to evaluate changes in body mass index (BMI) in breast cancer survivors within the first 2 years from initial encounter for a breast cancer (BC) diagnosis (dx), and investigate factors that may correlate with a change in BMI. Methods: We identified 5,423 BC patients (pts) in our electronic medical record, (1/2015-present), using ICD-10 code C50.X. We

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Desai, Nihar, Tommy Alfaro-Moya, Eshrak Al-Shaibani, et al. "Long-term outcomes of patients surviving beyond 2 years post–allogeneic stem cell transplantation." Journal of Clinical Oncology 43, no. 16_suppl (2025): 6508. https://doi.org/10.1200/jco.2025.43.16_suppl.6508.

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6508 Background: Advances in hematopoietic stem cell transplantation (HSCT) have been driven by progress in supportive care, conditioning regimens, and graft-versus-host disease (GvHD) prophylaxis. Post-transplant morbidity and mortality are most pronounced in the first two years after HCT. Long-term outcomes have been previously described in a CIBMTR study, which reported a 10-year survival of 85% for those who survived the first two years. Post-transplant cyclophosphamide (PTCy) has revolutionized transplant outcomes. However, its impact on long-term survival remains unclear. Methods: We inc

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Engler, N., H. M. Schmid, S. P. Quanz, H. Avenhaus, and A. Bazzon. "Detection of scattered light from the hot dust in HD 172555." Astronomy & Astrophysics 618 (October 2018): A151. http://dx.doi.org/10.1051/0004-6361/201832674.

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Context. Debris disks or belts are important signposts for the presence of colliding planetesimals and, therefore, for ongoing planet formation and evolution processes in young planetary systems. Imaging of debris material at small separations from the star is very challenging but provides valuable insights into the spatial distribution of the so-called hot dust produced by solid bodies located in or near the habitable zone. We report the first detection of scattered light from the hot dust around the nearby (d = 28.33 pc) A star HD 172555. Aims. We want to constrain the geometric structure of

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Willer, Robert J., Patrick W. Brady, Amy N. Tyler, Jennifer D. Treasure, and Eric R. Coon. "Transition to Weight-Based High-Flow Nasal Cannula Use Outside of the ICU for Bronchiolitis." JAMA Network Open 7, no. 3 (2024): e242722. http://dx.doi.org/10.1001/jamanetworkopen.2024.2722.

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ImportanceMost children’s hospitals have adopted weight-based high-flow nasal cannula (HFNC) bronchiolitis protocols for use outside of the intensive care unit (ICU) setting. Whether these protocols are achieving their goal of reducing bronchiolitis-related ICU admissions remains unknown.ObjectiveTo measure the association between hospital transition to weight-based non-ICU HFNC use and subsequent ICU admission.Design, Setting, and ParticipantsThis multicenter retrospective cohort study was conducted with a controlled interrupted time series approach and involved 18 children’s hospitals that c

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