Journal articles: '624.151 32'

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Kusumaningtyas, Rozhalia Uji, and Sri Suparti. "Stress and Anxiety Level of Nursing Students in Facing Practical Exam During Pandemic 19." Proceedings Series on Health & Medical Sciences 3 (December 28, 2022): 98–103. http://dx.doi.org/10.30595/pshms.v3i.627.

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Background: Persons enrolled in nursing school are prepared to advance into nursing in the future. Before engaging in nursing clinical practice in hospitals, nursing students are required to be able to advance their competence in the lab. Students studying nursing experience stress and anxiety due to the switch from online to offline lab learning. Objective: To determine and identify nursing students’ stress and anxiety levels in facing practical exams. Method: This study is cross-sectional quantitative descriptive research. A total of 190 nursing students from the second semester at Universitas Muhammadiyah Purwokerto participated in the study as the sample on April 20, 2022. The DASS-21 questionnaire for sub-stress and anxiety was modified for the research instrument. A univariate data analysis with frequency distribution was used as the data analysis. Results: The findings revealed that 115 (60.5%) nursing students reported normal stress, 32 (16.8%) mild stress, 23 (12.1%) moderate stress, 18 (9.5%) severe stress, and 2 (1.1%) very heavy stress. There were 32 (16.8%) students who moderate anxiety, 26 (13.7%) severe anxiety, and 28 (14.7%) very severe anxiety. Conclusion: Most nursing students preparing for practical exams experienced normal stress and moderate anxiety levels.

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Raičević, Jelena G., Ivan N. Pavlović, and Tamara A. Galonja-Coghill. "Canine intestinal parasites as a potential source of soil contamination in the public areas of Kruševac, Serbia." Journal of Infection in Developing Countries 15, no. 01 (January 31, 2021): 147–54. http://dx.doi.org/10.3855/jidc.12694.

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Introduction: Environmental contamination by infected canine faeces presents an indirect source of contamination in people. In this research the presence of parasitic elements in canine faeces found in the public areas of Kruševac was examined. Methodology: During May and October 2018, 282 samples were collected from different public areas (ten kindergartens, six public squares and four parks). The examination of faeces was performed by means of direct smear and flotation. For statistical testing of the difference between the frequencies of attributes χ2 test was applied. Results: Out of 282 samples, 221 (78.4%) were positive, of which 17/20 (85.0%) from kindergartens, 125/160 (78.1%) from parks and 79/102 (77.5%) from public squares. The presence of Ancylostomatidae spp. was discovered in 113 (40.1%) samples, Toxocara canis in 82 (29.1%), Dipylidium caninum in 76 (27.0%), Giardia intestinalis in 45 (16.0%), Taenia spp. in 44 (15.6%), Amoeba spp. in 32 (11.3%), Trichuris vulpis in 19 (6.7%), Toxascaris leonina in 18 (6.4%), Strongyloides stercoralis in 17 (6.0%), Isospora spp. in 7 (2.5%) and Cryptosporidium spp. in 3 (1.1%). In May there were 115/141 (81.6%) positive samples, whereas in October there were 106/141 (72.5%) positive ones. No positive sample with three or four parasites was found in October. Conclusions: This study shows that canine faeces from public areas in Kruševac can be the cause of a significant environmental contamination by eggs of canine intestinal parasites as well as of human infections.

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Voitl, Peter, Rosmarie Meyer, Astrid Woditschka, Christian Sebelefsky, Andreas Böck, and Verena Schneeberger. "Occurrence of patients compared in a pediatric practice and pediatric hospital outpatient clinic." Journal of Child Health Care 23, no. 4 (May 26, 2019): 512–21. http://dx.doi.org/10.1177/1367493519853431.

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The frequency of consultations and the waiting times in pediatric hospital outpatient clinics are steadily increasing. The aim of this study was to compare the occurrence of patients in a large pediatric group practice and a hospital-based general pediatric outpatient clinic. Primary parameters were the most common reasons for consultation, the waiting times and the reasons for selecting a certain institution. Most frequent diagnoses in the pediatric practice were upper respiratory tract infections (22.7% ( n = 141/621)), otitis media (5.2% ( n = 32/621)), and viral pharyngitis (3.9% ( n = 24/621)). Most common reasons for consultation in the hospital outpatient clinic were upper respiratory tract infections (18.4% ( n = 121/658)) and bacterial pharyngitis (17.9% ( n = 118/658)). In the pediatric practice, bacterial pharyngitis was only diagnosed in 3.1% ( n = 19/621) of the cases. Only slight differences exist between the two institutions regarding the observed entities, which mainly comprise mild to moderate acute illnesses. It can be concluded from this that the majority of patients might as well be treated in the nonhospital setting. Facilitating the communication and coordination between practices and hospitals might allow a better utilization of capacities. Thereby, waiting times, unnecessary reexaminations, and costs in the health-care system could be reduced.

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Yee, A., L. Siriwardhana, G. Nixon, L. Walter, F. Wong, and R. Horne. "P141 Periodic breathing in preterm infants before and after hospital discharge." SLEEP Advances 3, Supplement_1 (October 1, 2022): A75. http://dx.doi.org/10.1093/sleepadvances/zpac029.209.

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Abstract Introduction Preterm infants have immature respiratory control that can manifest as periodic breathing (PB). We aimed to investigate the relationship between time spent in PB before and after hospital discharge. Methods Preterm infants born between 28-32 weeks gestational age were studied during daytime sleep in the supine position for 2-4 hours at 32-36 weeks post menstrual age (PMA) (N=40), 36-40 weeks PMA (N=27), 3 months (N=20) and 6 months (N=26) corrected age (CA). The amount of PB was determined as percentage of total sleep time (TST) spent in PB (%TSTPB). Infants were grouped into below and above the median (8.5%TSTPB) at 32-36 weeks and compared to 36-40 weeks, 3 and 6 months with Mann-Whitney U tests. Results %TSTPB was not different between 32-36 weeks PMA (median 8.5%; IQR 1.5, 15.0) and at 36-40 weeks PMA (6.6% (0.9, 15.1), and then decreased at 3 (0.4%; 0.0, 2.0) and 6 months CA (0%; 0.0, 1.1). Infants who were above the median %TSTPB at 32-36 weeks PMA spent more time in PB at 36-40 weeks PMA [18.05% (7.7, 23.9) vs 2.1% (0.6, 6.4)] and 6 months CA [0.9% (0.0, 3.3) vs 0.0% (0.0, 0.0)]. Conclusions Percentage sleep time spent in PB did not decrease as preterm infants approached term CA, when they were ready to be discharged home. Preterm infants who had higher amounts of PB at 32-36 weeks PMA continued to have higher amounts of PB at term CA and their PB persisted up to 6 months CA.

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ΚΑΡΔΑΡΑΣ, Γεώργιος. "Βιβλιοκρισία: Neglected Barbarians, επιμ. εκδ. F. CURTA [Studies in the Early Middle Ages 32], Brepols Publishers n.v., Turnhout 2010. 629 σ., 24 έγχρωμες εικόνες, ISBN: 978-2-503-53125-0." BYZANTINA SYMMEIKTA 22 (April 26, 2013): 443. http://dx.doi.org/10.12681/byzsym.1114.

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Βιβλιοκρισία: Neglected Barbarians, επιμ. εκδ. F. Curta [Studies in the Early Middle Ages 32], Brepols Publishers n.v., Turnhout 2010. 629 σ., 24 έγχρωμε&sigmaf; εικόνε&sigmaf;, ISBN: 978-2-503-53125-0Negle

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Di Gioia, Giuseppe, Lorenzo Buzzelli, Viviana Maestrini, Antonio Nenna, Sara Monosilio, Maria Rosaria Squeo, Erika Lemme, and Antonio Pelliccia. "Lipid Profile in Olympic Athletes: Proposal for a “Lipid Athlete Score” as a Clinical Tool to Identify High-Risk Athletes." Journal of Clinical Medicine 12, no. 23 (November 30, 2023): 7449. http://dx.doi.org/10.3390/jcm12237449.

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Dyslipidemia is a major risk factor for atherosclerosis. Identification of dyslipidemia in athletes has raised interest in establishing preventive strategies and reducing cardiovascular (CV) events. Nowadays, targets or “scores” for athletes are undefined. The aim of our study was to create a “Lipid Athlete Score” based on lipid parameters and derive score indexes to identify high-risk athletes. We retrospectively enrolled 957 Olympic athletes practicing different sporting disciplines (power, skills, endurance, and mixed), analyzing their CV profiles and anthropometrics; 55.4% were male, the mean age was 27.1 ± 5 years, and the mean body mass index (BMI) was 23.1 ± 3.2 kg/m2. Three hundred and forty-three athletes (35.8%) were dyslipidemic (LDL ≥ 115 mg/dL or LDL/HDL ≥ 1.90). Multivariate analysis revealed the following: male p = 0.001, OR 1.88 [0.41–2.51], familiarity for dyslipidemia p = 0.001, OR 2.82 [1.72–4.59], BMI ≥ 30 kg/m2 p = 0.001, OR 2.53 [1.46–4.38], and fat mass p = 0.001, OR 2.29 [1.38–3.80] were significant. Endurance athletes presented the lowest CV risk. We proposed a lipid athlete score including major (LDL ≥ 115 mg/dL and LDL/HDL ≥ 1.90) and minor criteria (male, BMI > 30 kg/m2 or fat mass >22% for males and 32% for females, familiarity for dyslipidemia, and conventional CV risk factors). Twelve athletes (1.2%) were at high risk, 150 athletes (15.7%) at medium risk, 171 athletes (17.9%) at low risk, and 624 (65.2%) were at no risk. Dyslipidemia is very common in elite athletes. We have defined a specific lipid athlete score based on lipid parameters and derived score indexes for the stratification of risk. In accordance with this tool, a substantial proportion of athletes (16.9%) were at medium-to-high risk and need early preventive strategies to improve their lipid profiles and reduce the future development of atherosclerotic CV diseases.

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Dametto, Leonardo Luiz, Ezequiel Davi dos Santos, Luciana R. Santos, and Elci L. Dickel. "Bovine tuberculosis: diagnosis in dairy cattle through the association of analyzes." Pesquisa Veterinária Brasileira 40, no. 1 (January 2020): 12–16. http://dx.doi.org/10.1590/1678-5150-pvb-6294.

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ABSTRACT: Tuberculosis is a chronic anthropozoonosis of worldwide occurrence, caused by the bacterium Mycobacterium tuberculosis and its variants. In Brazil, the National Program for the Control and Eradication of Brucellosis and Tuberculosis in cattle, is responsible for diagnosing and the correctly allocate positive animals, but there is still a lack of definitive diagnosis of the disease. This study described the use of five diagnostic tools that can be used, preferably together, for the confirmation of suspected cases. These tools included the clinical examination comparative cervical tuberculin test, macroscopic findings during the slaughtering and histopathology of the damaged tissues followed by histochemistry. We evaluated a total of 211 dairy cattle, where 15.1% (32/211) had classic clinical signs of bovine tuberculosis, 74 (35%) showed reactivity in the comparative cervical tuberculin test. Of the total number of animals, 141 (66.8%) were referred for sanitary slaughter due to legal and control issues in the outbreaks of the disease. In the follow-up of slaughtering and inspection of viscera and carcasses, 74 (52.5%) had macroscopic lesions compatible with bovine tuberculosis, while 67 (47.5%) showed no visible changes. During the inspection, fragments of lymph nodes and liver and lung parenchyma were collected from five cattle with macroscopic lesions and five with no lesions. The histopathological analysis showed numerous areas of caseous necrosis with or without central calcification and granulomatous inflammatory infiltrate. In the special staining of Ziehl-Neelsen, numerous acid-fast bacilli were evidenced in all cases.

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Schultz, N. A., J. Werner, H. Willenbrock, A. Roslind, T. Horn, M. Wøjdemann, and J. S. Johansen. "MicroRNA expression profiles associated with pancreatic cancer." Journal of Clinical Oncology 29, no. 4_suppl (February 1, 2011): 153. http://dx.doi.org/10.1200/jco.2011.29.4_suppl.153.

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153 Background: The aim was: 1) to define the global microRNA (miRNA) expression pattern in pancreatic cancer (PC) and compare it with normal pancreas (NP) and chronic pancreatitis (CP); 2) to validate reported diagnostic miR profiles in PC; 3) to discover new diagnostic miRs in pancreas samples without micro-dissection of cancer cells. Methods: MiR expression patterns in FFPE tissue blocks from patients operated for pancreatic ductal adenocarcinoma (PDAC, n=170) and ampullary adenocarcinomas (A-AC, n=107) were determined using TaqMan Human miR microarrray (Applied Biosystem; 754 miRs were determined) and compared to profiles of CP (n=23) and NP (n=28). Raw Ct-values were normalized using quantile-normalisation. Results: 83miRs were differentially expressed in PDAC and NP (42 higher expression; 41 reduced expression in PDAC). 32 miRs were differentially expressed in PDAC and CP. The most differentially expressed miRs were miR-614, miR-492, miR-622, miR-135b* and miR-196. The miR signatures of PDAC and A-AC were highly correlated (0.99; only 5 miRs were significantly differentially expressed). An earlier reported diagnostic miR profile for PDAC was validated (mirR196b - miR217), and 3 other significant profiles were identified (Table). A more complex Lasso classifier using 19 miRs could separate PDAC from NP and CP (accuracy = 98%). Conclusions: We identified systematic differences in patterns of miR expressions between tumor tissue including both cancer cells and surrounding desmoplasia obtained from patients with PDAC and A-AC compared to tissue from patients with CP and NP. We validated the diagnostic miR expression profile (miR-196b, miR-217) described by Szafranska et al. (Clin Chem 2008;54:1716-24). Furthermore, we identified 5 miRs which were better to discriminate PDAC and A-AC from CP and NP. Prospective studies are needed to evaluate if this panel of miRs is useful for early diagnosis of patients with PDAC. [Table: see text] No significant financial relationships to disclose.

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Matveev, V. B., M. I. Volkova, N. L. Vashakmadze, and I. S. Stilidi. "Technique and short-term outcomes of surgical treatment in patients with renal cell carcinoma and tumor venous thrombosis: experience of the Urology Clinic, N.N. Blokhin National Medical Research Center of Oncology." Cancer Urology 17, no. 2 (July 25, 2021): 17–32. http://dx.doi.org/10.17650/1726-9776-2021-17-2-17-32.

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Objective: to describe the technique of nephrectomy and thrombectomy used in patients with renal cell carcinoma (RCC) and tumor venous thrombosis of various levels, and to identify risk factors of in-hospital death among operated patients.Materials and methods. This study included 768 patients with RCC and tumor venous thrombosis who have undergone surgical treatment. Median age was 58 years (range: 16-82 years); the male to female ratio was 2.3:1. The symptoms of venous tumor thrombosis were identified in 199 patients (25.9 %). In the majority of patients (n = 509; 66.3 %), the tumor thrombus originated from the right renal vein. The cranial border of the tumor thrombus was located in the perirenal inferior vena cava (IVC) in 219 patients (28.5 %), subhepatic IVC in 201 patients (26.2 %), intrahepatic IVC in 171 patients (22.3 %), and above the diaphragm in 177 patients (23.0 %). We used an individual approach to choose an optimal method of vascular control and to identify indications for circulatory support. Two-thirds of patients (n = 512; 66.7 %) underwent temporary block of the second renal vein; 268 patients (34.9 %) - temporary block of the hepatoduodenal ligament and right heart; 11 patients (3.2 %) were operated on with cardiopulmonary bypass.Results. The median surgery time was 190 ± 63.6 min; median blood loss was 3,000 ± 71.6 mL (≥50 % of circulating blood in 35.1 % of patients). Intraoperative complications were registered in 23 patients (3.0 %); eight patients (1.0 %) died during surgery with 4 of them died due to pulmonary embolism (0.5 %), 3 died due to hemorrhagic shock (0.4 %), and 1 died due to myocardial infarction (0.1 %). One hundred and ninety individuals (25.0 %) developed postoperative complications with Clavien-Dindo grade III-V complications observed in 115 cases (15.1 %). Forty-one patients (5.3 %) died in the early postoperative period. The causes of death included multiple organ dysfunction (n = 21; 2.8 %), pulmonary embolism (n = 7; 0.9 %), sepsis (n = 6; 0.8 %), stroke (n = 4; 0.5 %), myocardial infarction (n = 2; 0.2 %), and RCC progression (n = 1; 0.1 %). We have identified several independent risk factors for in-hospital mortality, including ascites (hazard ratio (HR) 8.3; 95 % confidence interval (CI) 3.2-21.4; p < 0.0001), preoperative pulmonary embolism (HR 3.5; 95 % CI 1.3-9.4; p = 0.013), supradiaphragmatic thrombi (HR 1.5; 95 % CI 1.1-2.0; p = 0.003). The in-hospital mortality rate was 3.5 % (20/575) among patients with no risk factors, 9.8 % (16/163) among those with 1 risk factor, 40.0 % (10/25) among those with 2 risk factors, and 60.0 % (3/5) among those with 3 risk factors (area under the curve (AUC) 0.705; p <0.0001 for all).Conclusion. The incidence of severe complications and postoperative mortality rate in RCC patients with tumor venous thrombosis who have undergone nephrectomy and thrombectomy were 15.1 and 6.4 %, respectively. Risk factors for perioperative mortality included ascites, preoperative pulmonary embolism, and supradiaphragmatic thrombosis.

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Fruth, Briant, Tom R. Fitch, Robert P. Shannon, Ryan Uitti, Elise Carey, Cory Ingram, Angelina D. Tan, et al. "A dynamic managed care platform for palliative care." Journal of Clinical Oncology 35, no. 31_suppl (November 1, 2017): 32. http://dx.doi.org/10.1200/jco.2017.35.31_suppl.32.

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32 Background: The link between patient concerns and clinical systems delivery is often suboptimal. We developed a case management system for palliative care which transforms the patient’s greatest concerns into actionable clinical pathways. Methods: The system collects patients’ single greatest and second greatest concern plus Quality of Life (QOL) data (pain, fatigue and overall QOL single-items scored 0-10 with 10 representing worst pain/fatigue, or best QOL) and produces a report to guide the physician and patient. The system presents ten “buttons” in a xylophone-like grid: Personal Relationships, Monitoring Health, Emotional Health, Money, Health Behaviors, Medication Troubles, Care Access, Work Worries, Physical Health and Care Planning. We performed a quality improvement study at Mayo Clinic sites. Results: 409 patients participated in at least one survey from 11/04/2015 to 9/22/2016 (620 total surveys). The most common Main Concern was Physical Health 265/620 (43%) followed by Monitoring Health (17%), Medication (8%), and Emotional Health, Money, and Health Behaviors (7% each), Personal Relationships (6%). Future Care Planning, Work, and Care Access/Coordination were rarely chosen ( < 5%). The most common Second greatest concern was Health Behaviors 73/409 (18%) followed by Physical Health (17%). 93/122 (67%) patients changed their greatest concern from baseline to subsequent visits. The mean QOL, fatigue and pain at baseline were 4.8, 6.0 and 4.8 respectively, indicating substantial clinically significant deficits. Post baseline mean scores improved by a maximum of 0.8, 1.1, and 0.9 points respectively, representing clinically meaningful effects. On average it took 8 minutes for patients to use the system. Conclusions: The system was quick and easy to utilize. The personal impact concerns (physical/emotional health, medications) were most often cited as the greatest concern, while care issues were de-emphasized by patients. Patients and physicians praised the system for making visits more efficient and raising issues that otherwise might not have been addressed. This system has the potential to improve patient well-being and clinical outcomes, as well as to reduce burden on clinicians and optimize case management activities.

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Rabia Asim, Humera Ismail, and Shehla Baqi. "Operation theatre time utilization during emergency surgeries at a government institute of trauma in Karachi, Pakistan." Journal of the Pakistan Medical Association 73, no. 05 (April 15, 2023): 1000–1006. http://dx.doi.org/10.47391/jpma.6776.

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Objective: To evaluate operation theatre time utilisation during emergency cases. Method: The prospective, observational study was conducted at the Shaheed Mohtarma Benazir Bhutto Institute of Trauma, Karachi, from January 17 to April 17, 2020, during which the three dedicated emergency operating rooms at the centre were monitored for time from transferring the patient to the operation theatre till the patient was is shifted out after surgery. Data was analysed using SPSS 24. Results: Of the total 1,287 surgeries performed, 625(48.56%) were included. Of them, 373(59.7%) patients were shifted to the operation theatre once it was ready, while 252(40.3%) were shifted in advance. There were 474(75.8%) male patients, and 151(24.1%) were females. The overall mean age was 32.7±17.4 years (range: 1 year to 47 years). Mean time of patient transfer to the operating room was 1:17±1:52 hours:minutes. Delay was recorded in 133(35. 6%) cases who were shifted from location when the operation theatre was available. It was caused in 64(17.15%) cases by surgical teams, another emergency surgery in the operating room 24(6.4%) and operating room cleaning 19(5%). The mean waiting time in the holding area was 1:25±1:21hours:minutes, and mean time from induction to surgical incision was 0:34±0:32 hours:minutes. Delays was caused by trainee surgeons in 79(12.64%) cases, and prolonged preoperative patient preparation in 99(15.84%). Mean turnover time was 0:48±0:42 hours:minutes. Delay was caused by post-operative unavailability of ambulance transportation 29(15%), and intensive care unit bed availability 14(7.2%). Conclusion: Time utilisation of emergency operation theatres can be maximised by improved overall coordination. Key Words: Government institute, Emergency, Operation theatre, Time sationutilisation.

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Teo, Carla Rosane Paz Arruda, Roberta Lamonatto Taglietti, Maria Assunta Busato, and Bibiane Signor. "Autopercepção e necessidades de saúde: recurso para enfrentar vulnerabilidades e reorganizar a atenção." Espaço para a Saúde - Revista de Saúde Pública do Paraná 17, no. 2 (December 29, 2016): 178. http://dx.doi.org/10.22421/1517-7130.2016v17n2p178.

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Objetivou-se analisar autopercepção e necessidades de saúde de um grupo populacional em um município de Santa Catarina. Foi realizado estudo descritivo-transversal, com 255 usuários de terminal rodoviário urbano. Utilizou-se questionário para coleta de dados demográficos, de autoavaliação de saúde, condição funcional, morbidade, necessidades de saúde. Dados quantitativos foram analisados por estatística descritiva e inferencial, com teste qui-quadrado de Pearson, a 5% de significância, no programa Statistical Package for Social Sciences. Dados qualitativos foram tratados por análise de conteúdo. A amostra foi composta predominantemente por mulheres (64,3%; 164), adultas (72,2%; 184), com ensino médio completo (39,2%; 100). A prevalência de autoavaliação de saúde negativa foi de 35,7% (91), maior entre idosos (54,2%; 32), portadores de morbidades (44,3%) e/ou de limitações funcionais (70,8%; 46). As necessidades de saúde foram relacionadas ao estilo de vida (62,4%; 151) e ao acesso a bens/serviços de saúde (26,4%; 64), estando associadas à autoavaliação de saúde. O perfil de idade e escolaridade observado explica a prevalência de autopercepção de saúde positiva e necessidades em dimensões biopsicossociais da vida. Sugere-se que os profissionais de saúde reflitam sobre percepções e necessidades de saúde dos usuários, como recurso para redução de vulnerabilidades e promoção da saúde.

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Malke, Horst. "R. WU (Editor). Recombinant DNA, Part F (Methods in Enzymology. Volume 155). XXIX + 628 S., 150 Abb., 32 Tab. San Diego — New York — Berkely — Boston — London — Sydney — Tokyo — Toronto 1987. Academic Press. $ 75.00. ISBN: 0–12–182056–4." Journal of Basic Microbiology 29, no. 6 (1989): 399. http://dx.doi.org/10.1002/jobm.3620290623.

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Friel, James K., Jamie C. Bessie, Suresh L. Belkhode, Colin Edgecombe, Merlee Steele‐Rodway, Geoff Downton, Poh Gin Kwa, and Khalid Aziz. "Thiamine, Riboflavin, Pyridoxine, and Vitamin C Status in Premature Infants Receiving Parenteral and Enteral Nutrition." Journal of Pediatric Gastroenterology and Nutrition 33, no. 1 (July 2001): 64–69. http://dx.doi.org/10.1002/j.1536-4801.2001.tb07403.x.

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ABSTRACTBackgroundThere is a paucity of data about water soluble vitamin status in low birthweight infants. Therefore, the authors' objective was to assess current feeding protocols.MethodsThe authors measured serum concentrations for riboflavin, pyridoxine, and vitamin C and functional assays for thiamine and riboflavin longitudinally in 16 premature infants (birthweight, 1,336 ± 351 g; gestational age, 30 ± 2.5 weeks) before receiving nutrition (time 1, 2 ± 1 days), during supplemental or parenteral nutrition (time 2, 16 ± 10 days) and while receiving full oral feedings (time 3, 32 ± 15 days). In plasma, vitamin C was measured colorimetrically, and riboflavin and pyridoxine were measured using high‐performance liquid chromatography. The erythrocyte transketolase test as a functional evaluation of thiamine and the erythrocyte glutathione reductase test for riboflavin were measured colorimetrically.ResultsAt time 1, nutrient intake of vitamins were negligible because infants were receiving intravenous glucose and electrolytes only. Intakes differed between time 2 and time 3 for thiamine (510 ± 280 and 254 ± 115 μg · kg −1 · d −1 , respectively), riboflavin (624 ± 305 and 371 ± 193 μg · kg −1 · d −1 , respectively), and pyridoxine (394 ± 243 and 173 ± 85 μg/100 kcal, respectively), but not for vitamin C (32 ± 17 and 28 ± 12 mg · kg −1 · d −1 , respectively). Blood levels at times 1, 2, and 3 were for thiamine (4.9 ± 2.7%, 3.3 ± 6.6%, and 4.1 ± 9% erythrocyte transketolase test, respectively), riboflavin (0.91 ± 0.31, 0.7 ± 0.3, 0.91 ± 0.18 erythrocyte glutathione reductase test, respectively), riboflavin (19.5 ± 17, 23.3 ± 8.6, 17.6 ± 10 ng/mL, respectively), pyridoxine (32 ± 25, 40 ± 16, 37 ± 26 ng/mL, respectively), and vitamin C (5.2 ± 3, 5 ± 2.2, 10 ± 5 μg/mL, respectively) and did not differ at those times.ConclusionsCurrent intakes of these vitamins, except for possibly vitamin C, during parenteral and enteral nutrition seem to result in adequate plasma concentrations and normal functional indices.

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Togni, Raquel, Cristina Laguna Benetti-Pinto, and Daniela Angerame Yela. "The role of diagnostic laparoscopy in gynecology." Sao Paulo Medical Journal 134, no. 1 (October 9, 2015): 70–73. http://dx.doi.org/10.1590/1516-3180.2014.00241501.

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ABSTRACT CONTEXT AND OBJECTIVES: Laparoscopy is a diagnostic method that is currently becoming consolidated for therapeutic use. It consists of endoscopically viewing the abdominal cavity. The aim here was to evaluate the indications for diagnostic videolaparoscopy and the intraoperative findings in an endoscopic gynecology clinic at a tertiary-level hospital over the last five years. DESIGN AND SETTING: Retrospective descriptive study on all diagnostic videolaparoscopy procedures of the last five years carried out in the endoscopic gynecology clinic of a tertiary-level hospital. METHODS: The medical records of 618 women who underwent diagnostic laparoscopy between 2008 and 2012 were analyzed. The clinical characteristics of these women, the indications for videolaparoscopy and the intraoperative findings were evaluated. RESULTS: The women's mean age was 32 ± 6.4 years. Most of the women had already undergone at least one previous operation (60%), which was most frequently a cesarean. The indications for performing videolaparoscopy were infertility in 57%, chronic pelvic pain in 27% and others (intrauterine device, adnexal tumor, ectopic pregnancy or pelvic inflammatory disease) in 16%. The main laparoscopic findings were tubal alterations in the group with infertility (59.78%) and peritoneal alterations in the group with chronic pelvic pain (43.54%). CONCLUSION: The main indications for videolaparoscopy in gynecology were infertility and chronic pelvic pain. However, in most procedures, no abnormalities justifying these complaints were found.

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BOWLES, BOBBY L., and ARTHUR J. MILLER. "Antibotulinal Properties of Selected Aromatic and Aliphatic Aldehydes." Journal of Food Protection 56, no. 9 (September 1, 1993): 788–94. http://dx.doi.org/10.4315/0362-028x-56.9.788.

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Aromatic and aliphatic aldehydes were tested for their effectiveness against Clostridium botulinum spores and cells. Six-tenths millimolar benzaldehyde, piperonal, phenylacetaldehyde, α-amylcinnamaldehyde, vanillin, or phenylglyoxal delayed germination in botulinal assay medium (BAM) broth after 6 h exposure at 32°C. Sporicidal activity was observed with 1.25 mM vanillin, 39 mM isobutyraldehyde, 156 mM pyruvaldehyde or valeraldehyde, 625 mM benzaldehyde, and 2,500 mM α-amylcinnamaldehyde. Twenty-five millimolars of cinnamaldehyde, phenylacetaldehyde, pyruvaldehyde, and vanillin were most active against vegetative cells at pH 7.0 in BAM broth, while 125 mM was required for benzaldehyde, acetaldehyde, piperonal, or phenylglyoxal. Three millimolars benzaldehyde, 5.0 mM phenylglyoxal, 150 mM cinnamaldehyde, 200 mM pyruvaldehyde and vanillin, and 300 mM piperonal inhibited 9 h dipicolinic acid release in BAM broth at 32°C. Spore resistance to a 20-min 80°C thermal treatment was reduced when challenged with prior exposure to 100 mM cinnamaldehyde, piperonal, pyruvaldehyde, vanillin, or phenylglyoxal. Inhibition by cinnamaldehyde, piperonal, and phenylglyoxal was retained in commercial canned chicken and in beef broths. Five millimolars of benzaldehyde, cinnamaldehyde, piperonal, pyruvaldehyde, or phenylglyoxal delayed neurotoxin production for 48 h at 32°C, while 25 mM was required for vanillin. These results indicate that certain aldehydes inhibit C. botulinum, and aromaticity improves efficacy.

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Nurliana, Nurliana, Idwan Sudirman, Mirnawati Sudarwanto, and Raden Roso Soejoedono. "Pengaruh Bakteriosin Produksi Bakteri Asam Laktat Isolat Indonesia terhadap Jumlah Bakteri dalam Susu Pasteurisasi." Jurnal Agripet 9, no. 1 (April 1, 2009): 50–56. http://dx.doi.org/10.17969/agripet.v9i1.622.

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The effect of bacteriocin produced by Indonesia Isolate of lactic acid bacteria toward total bacteria in pasteurized milkABSTRACT. The aim of this research was to study the ability of bacteriocin (amylocin) produced by Indonesian isolate of Lactic Acid Bacteria (LAB) (Lactobacillus amylovorus US 121) and its combination with nisin in pasteurized milk. The total bacteria was measured by plate count method. The antimicrobial activity of amylosin at 64 AU/ml had the same activity with nisin at 625 AU/ml and its combination between amylosin and nisin at 32 AU/ml and 312,5 AU/ml respectively against psychrotrophic, thermoduric bacteria and L. monocytogenes in pasteurized milk. However, combination of amylosin and nisin (32 AU/ml + 312,5 AU/ml) able to reduce S. aureus in pasteurized milk. Amylosin at 64 AU/ml kept the shelf life of pasteurized milk longer until 12 days at 10oC. The addition of amylosin (the precipitate resulted by ammonium sulfate precipitation at 70% w/v) changed the color of pasteurized milk be brownish white.

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Cho, Min-Sun, Hee Jung Choi, Hae Kyung Park, Sung Eun Cho, Woon Sup Han, and Woo Ick Yang. "Questionable Role of Human Herpesviruses in the Pathogenesis of Kikuchi Disease." Archives of Pathology & Laboratory Medicine 131, no. 4 (April 1, 2007): 604–9. http://dx.doi.org/10.5858/2007-131-604-qrohhi.

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Abstract Context.—Kikuchi disease is a self-limiting febrile lymphadenopathy characterized by a patchy area of apoptosis. Kikuchi disease is thought to be caused by a virus, but this has not been clearly demonstrated. Human herpesviruses 6 and 7 (HHV-6 and HHV-7) are lymphotropic viruses that can induce apoptosis in infected lymphocytes. Recently, HHV-8 was reported to be a possible etiologic agent of Kikuchi disease. Objective.—To investigate the incidence of HHV-6, HHV-7, and HHV-8 infection in patients with Kikuchi disease. Design.—Seventy archival tissue specimens (from 50 Kikuchi disease cases and 20 control cases) were tested for the presence of HHV-6 and HHV-7 using a nested polymerase chain reaction, and for the presence of HHV-8 using single-step polymerase chain reaction. Immunohistochemistry for HHV-8 expression was carried out in those cases in which HHV-8 was detected using polymerase chain reaction. Results.—Of the 50 cases with Kikuchi disease, 21 (42%) were HHV-6 positive and 32 (64%) were HHV-7 positive. Eight (40%) of the 20 control cases were HHV-6 positive and 9 (45%) were HHV-7 positive. Both HHV-6 and HHV-7 were detected in 15 (30%) of the cases with Kikuchi disease and in 3 (15%) of the control cases. Three (6%) of the 50 cases of Kikuchi disease were HHV-8 positive but revealed no positive cells on immunohistochemical analysis for HHV-8. Human herpesvirus 8 was not expressed in any of the control cases. Conclusions.—There was no association between the presence of HHV-6 or HHV-7 and Kikuchi disease. Because the HHV-8 genome but not protein was detected in a small proportion of the cases of Kikuchi disease, its potential causative role in this disease should be determined by further studies.

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Plua, William, Hazel Anderson Vásquez, and Karina Jarrim. "Impacto del bypass gástrico sobre el Índice masa corporal de adultos diabéticos en el primer año postquirúrgico." RECIAMUC 6, no. 3 (July 19, 2022): 612–24. http://dx.doi.org/10.26820/reciamuc/6.(3).julio.2022.612-624.

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La obesidad y la Diabetes Mellitus tipo 2 representan un problema de salud pública a nivel mundial. El bypass Gástrico con Y de Roux (BPGYR) se considera la técnica quirúrgica de referencia en el tratamiento a largo plazo de la obesidad severa. La presente investigación tuvo como objetivo determinar el impacto del BPGYR sobre el índice de masa corporal de adultos diabéticos en el primer año postquirúrgico. La muestra estuvo conformada por 32 obesos diabéticos tipo 2 (11 hombres y 21 mujeres con una edad promedio de 39±10 años). Se realizó evaluación antropométrica (Peso, talla, IMC, % perdido del exceso de IMC (%PPEIMC), % de peso excedido perdido (%PEP) Se aplicó t de Student y Chi cuadrado. Se encontró que los hombres presentaron un peso corporal de 133±28 kg, IMC=43,7±6,8 kg/m2, IMC deseable=27,4±2,96 kg/m2; mientras que en las mujeres, el peso promedio fue 101±16 kg, IMC =38±5 kg/m2 y un IMC deseable de 25±2,1 kg/m2. La pérdida de peso corporal al año fue de 31,1±10,2 kg con un % PEP de 44,9±12,5% y % PPEIMC 78,4±14,0% En cuanto al porcentaje de IMC corporal perdido al año de la cirugía el 75% logró una pérdida excelente (80% de las mujeres y 64% de los hombres), 9 % bueno Y 16% malo. Se concluye que el BPGYR es una estrategia quirúrgica útil en la pérdida de peso corporal de estos pacientes.

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Walbank, Michael B. "Notes on Attic Decrees." Annual of the British School at Athens 85 (November 1990): 435–47. http://dx.doi.org/10.1017/s0068245400015781.

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Several fragments of 4th-century BC Athenian decree-inscriptions are discussed. Joins are made betweenIGii2. 13a and 68 andHesperia, 40, no. 3;IGii2. 257 and 300; 242 and 373; 407 andSEG32. 94;IGii2. 309 and 552; 530 and 590. Attributed to the same stele, but not joining, areIGii2. 139 and 289; 277 and 428; 540a andSEG24. 117;IGii2. 540b andHesperia, 21, no. 17;IGii2. 286 and 625; 414a and 403; 398a (+ 438) and 612; 484 and 558; 489 and 532; 495 and 709; 405 andHesperia, 4, no. 32. Other decrees discussed, mainly in light of the work of A.S. Henry on the formulae of Athenian decrees, areIGii2. 44; 81; 121; 129; 147; 154; 155; 156; 285+ 414d; 321; 335; 364; 406; 416; 1001; andSEG21. 362 and 25. 85.

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Thakur, Preet, U. K. Chandel, and A. K. Kaundal. "Evaluation of Site of Perforation among Secondary Peritonitis Cases and its Association with Outcome in a Tertiary Care Hospital." International Academic Research Journal of Surgery 2, no. 04 (July 10, 2022): 10–13. http://dx.doi.org/10.47310/iarjs.2022.v02i04.003.

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Background: The present study was carried out to evaluate the Site of Perforation among Secondary Peritonitis cases and its association with outcome in a tertiary care Hospital. Material and Methods: This cross sectional study was conducted by Department of Surgery, IGMC, Shimla over a period of twelve months from January 2021 – December 2021 among patients with a diagnosis of secondary peritonitis after fulfilling the inclusion and exclusion criteria. Relevant information was collected and further analysed by using IBM SPSS Statistics. Results: A total of 250 individuals with a diagnosis of perforation peritonitis were assessed in the current study. Males made up 205 (82%) of the total while females made up 45 (18%). The patients' average age was 47.28 17.34 years, ranging from 18 to 87. In the study, 99 (39.6%) of the total patients were under the age of 40, while 151 (60.4%) were beyond the age of 40. Of the total, 32 (12.80%) passed away while 218 (87.20%) were discharged after receiving treatment. The Most common cause was Duodenal perforation among 91 patients (36.4%), Gastric perforation among 83 patients (33.2%), Ileal perforation among 32 patients (12.8%), Jejunal perforation among 16 patients (6.4%) and Other among 28 patients (11.2%). Among the patients who expired due to Secondary Peritonitis, maximum 12(37.5%) had Gastric Perforation followed by Duodenal Perforation in 9 (28.1%) patients. Conclusion: The study concluded that most of patients of secondary peritonitis had Duodenal perforation followed by Gastric perforation. The most common type of perforation among patients who died from secondary peritonitis was gastric followed by duodenal.

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Wang, Angela A., and Douglas T. Hutchinson. "Syndactyly release: a comparison of skin graft versus graftless techniques in the same patient." Journal of Hand Surgery (European Volume) 44, no. 8 (May 16, 2019): 845–49. http://dx.doi.org/10.1177/1753193419848989.

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Syndactyly release may be done by skin graft or graftless techniques. We prospectively examined bilateral syndactyly releases in the same patient at one operation. The grafted side was randomized and the contralateral side was done graftless. Fourteen patients had surgery at a mean age of 27 months (range 7–166). The mean follow-up was 52 months (range 6–111). The mean tourniquet time was 97 minutes (range 66–135) for graft and 84 minutes (55–120) for graftless. The mean finger abduction was 57° (32°–80°) for graft and 54° (38°–80°) for graftless. The mean web creep score was 1.2 (0–3) for graft and 2.1 (0–3) for graftless. The mean scar score was 1.9 (1–3) bilaterally. The mean parents’ visual analogue scale for graft cosmesis was 7.1 (5–9) and 6.2 (4.3–8) for graftless. The surgeon’s visual analogue scale for graft was 7.9 (6.4–9.5) and 6.2 (4–8.7) for graftless. The therapist’s visual analogue scale was 7.9 (6.5–10) and 6.4 (4.7–8) for graftless. Although there is a longer tourniquet time with grafting, there may be advantages in appearance and web creep. Level of evidence: II

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Анзоров, В. А., М. Х. Губжукаева, and И. М. Демелханова. "ВЛИЯНИЕ БЕРЕМЕННОСТИ НА КАРТИНУ КРОВИ ЖЕНЩИН." Известия Чеченского государственного университета, no. 4/32 (December 21, 2023): 34–39. http://dx.doi.org/10.36684/12-2023-32-4-34-39.

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В работе приведен гематологический состав крови женщин в процессе развития беременности. Оценка результатов исследований показывает, что в период вынашивания плода происходит значительное снижение уровня эритроцитов, гемоглобина, лейкоцитов и существенное увеличение количества лимфоцитов в крови женщин. Так, содержание эритроцитов в крови женщин во втором триместре беременности снизилось до 3,6 млн. в мкл, а исходная величина составила 4,3. Концентрация гемоглобина в середине беременности упала до 110 г/л, а у контрольных женщин составила 131. Уровень лейкоцитов во второй трети беременности вырос до 8,6 тыс. в мкл крови, в последней – до 9,9 тыс. в мкл, а у небеременных составил 6,9. Минимальное количество тромбоцитов – 234 тыс. в мкл содержалось в крови женщин к концу беременности, а максимальное – 251 – в первом триместре. Количество нейтрофилов в крови женщин в последнем триместре беременности выросло до 72,8%, а исходная величина составила 62,4. Разница между максимальным и минимальным содержанием в крови базофилов, эозинофилов и моноцитов между группами составила по 0,2%. Концентрация лимфоцитов во втором и третьем триместре снизилась до 20,1 и 18,6%, а у контрольных женщин составила 29,0.

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Khmelnychyi, L., A. Loboda, and D. Bardash. "Features of the conformation type of first-born cows of Ukrainian Black-and-White and Red-and-White Dairy breeds." Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva, no. 2(150) (December 17, 2019): 21–32. http://dx.doi.org/10.33245/2310-9289-2019-150-2-21-32.

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Research of first-born cows of Ukrainian Black-and-White and Red-and-White Dairy breeds by linear traits was carried out. Research was conducted at the enterprises of the "Ukrlendfarminh" company: PE "Burynske" of Pidlisnivskoho Branch of Sumy District and LLC "Mlynivsky Complex" of Romny Branch of Sumy Region. According to the 100-point linear classification system, an interbreed difference was determined with the best indicators of animals of Ukrainian Black-and-White Dairy breed. The average scores of both breeds for the group traits and final assessment ranged from "good with plus" (80–84 scores). According to the estimation of group traits of dairy type, the predominance of animals of Ukrainian Black-and-White Dairy breed over Red-and-White was 1.3 scores (P <0.001); according to assess the condition of limbs and hooves, the difference was in favor of cows of Ukrainian Red-and-White Dairy breed with a difference of 1.3 scores (P <0.001). The best developed udder was found in cows of Ukrainian Black-and-White Dairy breed, which outperformed the peers of Ukrainian Red-and-White one by 1.4 scores with high reliability (P <0.001). As a result, the final score was higher in cows of Ukrainian black-and-White Dairy breed (83.0 scores) with a slight but significant superiority of peers Ukrainian Red-and-White Dairy breed, which was 0.4 scores (P <0.01). The developmental level of 18 descriptive traits of cows showed their considerable variability both within breeds and within each breed. In general, the evaluated animals of Ukrainian Black-and-White Dairy breed are characterized by well-pronounced height (6.3 scores), body depth (7.2 scores), angularity (6.8 scores), slope (5.1 scores) and rear width (6,5 scores), front udder parts attachment (6.5 scores), central ligament (6.4 scores) and udder depth (6.6 scores). The first-born cows of Ukrainian Red-and-White Dairy breed have better developed chest in width (6.9 scores) and body depth (7.5 scores), stronger hooves (6.4 scores). The conformation of animals of Ukrainian Black-and-White Dairy breed had a good characteristic of descriptive traits that determined their milkiness and for Ukrainian Red-and-White Dairy breed – strength. Key words: Ukrainian Black-and-White Dairy breed, Ukrainian Red-and-White Dairy breed, linear assessment, conformation, type, milk productivity.

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Stewart, Emma, Andrew P. Prayle, Alison Tooke, Sara Pasalodos, Mohnish Suri, Andy Bush, and Jayesh M. Bhatt. "Growth and nutrition in children with ataxia telangiectasia." Archives of Disease in Childhood 101, no. 12 (August 29, 2016): 1137–41. http://dx.doi.org/10.1136/archdischild-2015-310373.

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BackgroundAtaxia telangiectasia (A-T) is a rare multisystem disease with high early mortality from lung disease and cancer. Nutritional failure adversely impacts outcomes in many respiratory diseases. Several factors influence nutrition in children with A-T. We hypothesised that children with A-T have progressive growth failure and that early gastrostomy tube feeding (percutaneous endoscopic gastrostomy, PEG) is a favourable management option with good nutritional outcomes.MethodsData were collected prospectively on weight, height and body mass index (BMI) at the national paediatric A-T clinic. Adequacy and safety of oral intake was assessed. Nutritional advice was given at each multidisciplinary review.Results101 children (51 girls) had 222 measurements (32 once, 32 twice, 24 thrice) between 2009 and 2016. Median (IQR) age was 9.3 (6.4 to 13.1) years. Mean (SD) weight, height and BMI Z-scores were respectively −1 (1.6), −1.2 (1.2) and −0.4 (1.4). 35/101 children had weight Z-scores below −2 on at least one occasion. Weight, height and BMI Z-scores declined over time. Decline was most obvious after 8 years of age. 14/101 (14%) children had a PEG, with longitudinal data available for 12. In a nested case control study, there was a trend for improvement in weight in those with a PEG (p=0.10).ConclusionsPatients with A-T decline in growth over time. There is an urgent need for new strategies, including an understanding of why growth falters. We suggest early proactive consideration of PEG from age 8 years onwards to prevent progressive growth failure.

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Rovo, Alicia, Thomas Daikeler, Joerg Halter, Dominik Heim, Jan Dirk Studt, Michael Medinger, Caroline Arber, et al. "Late Altered Organ Function in Long Term Survivors after Allogeneic HSCT: A Paired Comparison with Their Identical Sibling Donor." Blood 112, no. 11 (November 16, 2008): 4298. http://dx.doi.org/10.1182/blood.v112.11.4298.4298.

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Abstract Long term prognosis following allogeneic hematopoetic cell transplantation (HSCT) has greatly improved over the last decades. Therefore, interest of the general health status has become a major topic in the surveillance of long term survivors. To assess health status in very long term survivors (>10 years follow-up) we conducted a prospective, single center cross-sectional study, evaluating simultaneously 44 recipients and their respective sibling donors. A comprehensive clinical and biological examination was performed. We compared here in a paired analysis the results of routine clinical chemistry tests between recipients and their respective donor (table 1). At the time of this study, recipients and donors had a median age of 44.3 (24–63) and 43.4 (22–61) years respectively, and a median time of 17.5 (11–26) years since HSCT; 22/44 (50%) recipients had chronic graft-versus-host disease (cGVHD). Performance status demonstrated that 81/88 (92%) participants had a Karnofsky Score of 100%, reflecting the overall good clinical condition of both, recipients and donors (p>0.10). However, clinical chemistry tests of the recipients were systematically abnormal, with increased C-reactive protein (CRP), liver tests, lipids, von Willebrand factor antigen (vWF), creatinine, and decreased albumin, and glomerular filtration rate (GFR), compared with the donors (p<0.05; table 1). In the recipients, increased CRP, creatinine, vWF and decreased GFR were associated with chronic GvHD (p<0.05). For the other parameters no correlation with transplant related factors were found. Furthermore, we defined a scoring system to detect organ dysfunctions. All values out of range were allocated with one point. Included parameters were: high CRP, decreased GFR, low albumin, increased vWF, abnormal liver tests and dyslipidemia We compared recipients/donors with a score of ≥2 to those with a score below this value. An abnormal score was observed in 28/44 (64%), recipients, and in 7/44 (16%) donors (p<0.0001). More recipients with cGVHD had an abnormal score (13/22; 59%) compared to recipients without (5/22; 23%; p= 0.014). In conclusion, using a unique design comparing recipients with their respective donor, we demonstrate that an altered organ function may exist in clinically healthy very long term survivors. In part, this altered organ function is attributed to cGVHD reflected by an ongoing inflammatory process even in patients off immunosuppression. The clinical significance of the altered organ function not explained by cGVHD needs to be further investigated. Table 1: Clinical chemistry parameters: comparison between long-term survivors and their respective donor (with and without GvHD). Parameter Donors N 44 Recipients P-values donors versus recipients All N 44 with GVHD N 22 without GVHD N 22 All recipients with/without GVHD C-Reactive Protein (CRP) 1.0 (0.5–38.1) 3.7 (0.5–79.2) 4.5 (0.9–79.2) 1.2 (0.5–11.0) 0.034 0.001/0.125 Creatinine 66 (45–93) 79 (44–206) 88 (55–206) 77 (44–103) 0.0001 <0.0001/0.007 Glomerular Filtration Rate (GFR) 107 (72–144) 82 (30–141) 77 (30–124) 95 (66–141) <0.0001 <0.0001/0.034 Albumin 41 (29–46) 40 (31–45) 38 (31–43) 40 (32–45) 0.009 0.021/0.361 Bilirubine 9.5 (5–29) 8.0 (5–20) 8.0 (5–17) 7.0 (5–20) 0.020 0.213/0.053 ASAT 22 (16–64) 27.5 (15–65) 26 (20–65) 28 (15–44) 0.0004 0.002/0.013 ALAT 22 (10–101) 25.5 (12–72) 27 (12–70) 23 (12–72) 0.037 0.030/0.161 Gamma-GT 18 (9–140) 31 (10–319) 30 (11–319) 32 (10–91) 0.0003 0.002/0.005 Alkaline Phosphatase 56 (32–155) 69 (39–222) 70 (39–222) 68 (41–120) 0.003 0.016/0.034 Triglicerides 1.0 (0.45–3.9) 1.5 (0.53–8.9) 1.5 (0.53–8.9) 1.6 (0.69–3.7) 0.011 0.208/0.007 Cholesterol 4.7 (3.1–9.3) 5.1 (2.7–7.8) 5.0 (2.7–7.8) 5.3 (3.7–6.4) 0.118 0.407/0.058 HDL-cholesterol 1.6 (1.0–3.2) 1.5 (0.6–2.5) 1.5 (0.6–2.5) 1.5 (1.0–2.2) 0.037 0.213/0.124 Chol/HDL-chol. Ratio 2.9 (1.7–8.6) 3.2 (1.8–8.7) 3.1 (1.8–8.7) 3.4 (1.8–5.7) 0.022 0.094/0.047 LDL-cholesterol 2.4 (1.4–7.7) 2.8 (1.07–4.8) 2.7 (1.1–4.8) 2.9 (1.1–3.9) 0.126 0.284/0.145 Von Willebrand factor Antigen (vWF) 97.5 (55–188) 126 (51–296) 139 (51–296) 108 (51–235) 0.006 0.002/0.173

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Rayi, Appaji, Iyad Alnahhas, Rachel Smith, Pierre Giglio, and Vinay Puduvalli. "EPID-32. IS THERE ANY EVIDENCE OF REPORTING AND CITATION BIAS AMONG COMPLETED PHASE III INTERVENTIONAL BRAIN TUMOR TRIALS?" Neuro-Oncology 21, Supplement_6 (November 2019): vi81. http://dx.doi.org/10.1093/neuonc/noz175.332.

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Abstract OBJECTIVE Reporting and citation bias based on positive versus negative outcome among completed phase III interventional brain tumor trials (IBTTs) have not been previously reported. Thus, we aimed to assess the evidence. METHODS Clinicaltrials.gov was used to obtain all phase III IBTTs completed prior to December 31st 2016. Trials closed due to poor accrual or non-phase III were excluded. Data about the funding source, type of intervention, conducted at U.S or Non-U.S locations, patients enrolled, primary completion date, time to dissemination of results in months (either reported on clinicaltrials.gov or published in a journal), citations per year (from web of science) and outcome (positive or neutral/negative) were abstracted. Median time to dissemination was estimated using Kaplan-Meier estimates and a log rank test for statistical significance. The number of citations per year for positive and negative/neutral studies was compared using a t-test. RESULTS 65 studies were analyzed. The median time from primary completion to dissemination of results for trials with a positive outcome was 20 months (n = 20; 95% CI: 12–31) compared to 30 months for trials with a negative outcome (n=35; 95 % CI: 22 – 37) (p = 0.095). The average number of citations per year for trials with a positive outcome is 62.4 (n = 21; range 1.1 – 614.8) compared to 25.0 for trials with a negative outcome (n=35; range 0.14 - 158.8) (p = 0.213). There was no significant difference in time to dissemination based on the funding source, type of intervention or the location where the trial was conducted. CONCLUSION Positive phase III IBTTs results are disseminated earlier and are cited more frequently compared to negative trials. However, there is no statistically significant evidence of reporting or citation bias.

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Calegari, Maria Alessandra, Santa Monterisi, Alessandro Inno, Armando Orlandi, Michele Basso, Alessandra Cassano, Daniele Santini, et al. "A phase 2 study of temozolomide in patients affected by pretreated metastatic colorectal cancer with MGMT promoter methylation." Journal of Clinical Oncology 35, no. 4_suppl (February 1, 2017): 629. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.629.

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629 Background: Presently few options are available for pts with mCRC who failed standard treatments and prognosis remains grim. MGMT promoter methylation is a frequent and early event in CRC tumorigenesis. This epigenetic silencing is a predictor of response to the alkylating drug TMZ in glioblastoma. Preclinical evidences and a couple of clinical cases showed TMZ activity in pts affected by mCRC with MGMT silencing. We designed a study to evaluate the efficacy and safety of TMZ in pts with refractory mCRC harboring MGMT promoter methylation. While the trial was ongoing three analogous studies, reporting discordant results, were published. Methods: This was a 3-institutional, single arm, phase 2 trial, planned according to a 2-stage Simon’s optimal design. The primary endpoint was ORR. Secondary outcomes included DCR, OS, PFS and safety. A first cohort of 21 pts was accrued: if more than 1 response was observed a second cohort of 20 pts would be enrolled; if 4 or fewer responses were observed by the end of stage two, then no further investigation would be warranted. MGMT promoter methylation was assessed on archival tissue samples by MS-PCR. Patients affected by MGMT methylated mCRC, who failed 2 or more prior treatments, received TMZ, provided by TEVA Pharmaceutical Industries, at a dose of 150-200 mg/mq/day once a day on days 1-5 every 28 days. Results: From July 2012 to June 2016, 225 pts were screened and 80 showed MGMT promoter methylation, among those 42 met the inclusion and exclusion criteria and were enrolled. ORR was 10% with no CR and 4 (10%) PR. SD was achieved in 9 (22%) pts, accounting for a DCR of 32%. At a median FU of 9 months all pts experienced PD and 88% died. Median PFS and OS were 2.6 months (95% CI 2.1-3.2) and 7.1 months (95% CI 5.1-9.2) respectively. Overall, any-grades AEs were reported in 75.6% pts, most of them were G1-2 (84%). The most frequent AE were nausea (56%) and platelet count decreased (39%). 4 pts discontinued study treatment due to AE. No SAE neither toxic death was recorded. Conclusions: The study did not meet its primary endpoint, however an interesting DCR (32%) and 4 PR were achieved. The role of TMZ in mCRC treatment remains still controversial and might warrant further analysis. Clinical trial information: 2012-002766-13.

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Cue, R. I., D. Pietersma, D. Lefebvre, R. Lacroix, K. Wade, D. Pellerin, A.-M. de Passillé, and J. Rushen. "Growth modeling of dairy heifers in Québec based on random regression." Canadian Journal of Animal Science 92, no. 1 (March 1, 2012): 33–47. http://dx.doi.org/10.4141/cjas2011-083.

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Cue, R. I., Pietersma, D., Lefebvre, D., Lacroix, R., Wade, K., Pellerin, D., de Passillé, A-M. and Rushen, J. 2012. Growth modeling of dairy heifers in Québec based on random regression. Can. J. Anim. Sci. 92: 33–47. A total of 144 006 weight (calculated from tape girth measurements) and height data records from Québec dairy heifers were analyzed using random regression to estimate growth curve parameters of Ayrshires, Brown Swiss and Holstein animals to permit prediction of individual heifer growth from 0 to 32 mo. There were, on average, 5.15 records per heifer (minimum 3 records, maximum 25 records). The body weight data were analyzed using linear and quadratic fixed and random regressions, with a power-of-the-mean (POM) function to model the residual variance. The POM was 1.2 for Holstein and Ayrshire and slightly less than 1 for Brown Swiss. Estimated body weight at 24 mo was 507, 564, 624 kg, for Ayrshires, Brown Swiss and Holstein, respectively. The height data were analyzed with a Brody, monomolecular non-linear growth curve model. Mature height was estimated to be 148 cm in both Holstein and Ayrshires, and 150 cm in Brown Swiss. Random regression models were shown to be able to predict individual growth, and can be incorporated in decision-support tools to help producers reducing the average age at first calving.

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Benton, Melissa J., Jefferson M. Spicher, and Sherry McCormick. "Community-Based Survey Exploring Use of the Dietary Supplement Creatine by Adult Non-Athletes." Nutrients 13, no. 8 (July 24, 2021): 2529. http://dx.doi.org/10.3390/nu13082529.

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Creatine is classified as a “sports supplement”, but it also has health benefits. The purpose of this study was to assess use of creatine as a dietary supplement in adult non-athletes. Three hundred ninety-nine adults (19–89 years) completed an online survey. Among the respondents, 77% (n = 307) were regularly active, including participation in weightlifting (34%), running (34%), and cycling (21%). Twenty-eight percent (n = 111) reported use of creatine with an average dose of 6.4 ± 4.5 g. Daily creatine use was reported by 45%, and 38% reported using creatine 2–6 times weekly. Primary sources of information about creatine were trainers/coaches (29%), friends/family (32%), and internet (28%). Forty percent (n = 44) of creatine users were female. When compared by age, 46% of young, 32% of midlife, and 6% of old respondents reported creatine use with no differences in dose or frequency. Young and midlife respondents reported primarily trainers/coaches, friends/family, and internet as sources of information about creatine, but old respondents limited their sources to friends/family and fitness magazines. Although creatine is widely used by adult non-athletes who regularly exercise, dietitians and other healthcare providers are not the primary source of information. Fitness trainers can appropriately provide guidance and education regarding safe and effective use of creatine.

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Lubetsky, Aharon, Edit Dekel-Stern, Angela Chetrit, Flora Lubin, and Hillel Halkin. "Vitamin K Intake and Sensitivity to Warfarin in Patients Consuming Regular Diets." Thrombosis and Haemostasis 81, no. 03 (1999): 396–99. http://dx.doi.org/10.1055/s-0037-1614485.

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SummaryThe effect of dietary vitamin K intake on warfarin sensitivity is known only from case reports and few small clinical studies. We followed 50 patients commencing warfarin and consuming their regular diets (for 8 weeks) to study this relationship. A one-week recall dietary questionnaire was completed at weeks 2 and 8. Daily intake of nutrients and vitamin K was calculated from standard tables. Warfarin sensitivity index (WSI) was defined as final INR/final warfarin dose (mg/day/m2 of body surface area) (week 8). Vitamin K intake was 17-974 (median: 179) μg/day. Median WSI was 0.82 (0.31-4.47). A WSI value of 1.1 significantly separated excess (≥250 μg/day) from normal (<250 μg/day) vitamin K consumers (16/18 vs. 15/32, respectively, p <0.01). The former had lower day 5 INR (median: 1.9 vs. 3.0, p <0.001), needed more warfarin to achieve INR ≥2.0 (32.0 ± 9.2 mg vs. 25.4 ± 6.4 mg, p = 0.009) and required a higher maintenance steady state warfarin dose (5.7 ± 1.7 mg/day vs. 3.5 ± 1.0 mg/day, p <0.001).We conclude that in 32% (16/50) of anticoagulated patients under usual dietary conditions sensitivity to warfarin is decreased by vitamin K intake ≥250 μg/day.

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Machhua, S., R. Minz, S. K. Sharma, H. Singh, Y. Kumar, S. Anand, S. Handa, and S. Singh. "AB0013 HLA ASSOCIATION WITH SYSTEMIC SCLEROSIS (SSc) IN NORTH INDIAN POPULATION AND FAMILIAL INHERITANCE PATTERNS." Annals of the Rheumatic Diseases 79, Suppl 1 (June 2020): 1310.1–1310. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5338.

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Background:It is widely believed that SSc develops in an individual with a permissive genetic makeup.Genetic influences have long been suspected to impact SSc. In families with a history of SSc, the incidence of disease can range from 1.5 to 1.7% (1). There are several reports of familial occurrence and certain alleles of the HLA system have been associated with the disease (2).No Indian data pertaining to genetic basis of systemic sclerosis is present. Understanding the genetic basis of the disease will help us in defining the biomarkers of the disease in the population that can help in early diagnosis and prognosis.Objectives:To study HLA association with Systemic sclerosis (SSc) in North Indian Population and its genetic susceptibility to familial systemic sclerosis.Methods:A total of 150 SSc patients diagnosed by following ACR and EULAR criteria and 150 control subjects, were genotyped for HLA-A, B, DRB1, DQB1 loci by Luminex® 200 Instrument (USA). The association of alleles with disease susceptibility was tested by Chi-square test and Fisher’s exact test.HLA Typing for HLA class I (A, B, C) and II(DR,DQ,DP) for familial study of systemic sclerosis in 2 families was performed by Next Generation Sequencing(NGS) with illumina MiniSeq using MIA FORA NGS Kits from IMMUCOR. Antinuclear patterns (ANA) and specific antibodies were detected by indirect Immunofluorescence and Immunoblot (Euroline, Germany).Results:Strong disease associations were observed for haplotypes A*24(OR=1.7;< 0.02), A*32(OR=2.8;< 0.02), B*35(OR=1.7;< 0.03), DRB1*11(OR=2.1;< 0.007). The reduced frequencies of haplotypes A*68(P< 0.05), DRB1*10(P< 0.05), DRB1*12 (P<0.00) among patients suggested a protective association. There was no statistical association found with HLA DQB*1.Through NGS we observed that in the 1stfamily haplotypes HLA –A*11, 32, 24; B* 51, 55, 35; C*-14, 04; DRB1*15, 04; DQB1*05, 03; DPB1*04, 26 appears in affected family members with serological abnormalities.In the 2ndfamily both mother and daughter had same set of haplotypes except DQB1 with serological abnormalities. The haplotypes DPB1*04 was present in all the diseased individuals of both the families (Fig. 1 and table 1).Table 1.NGS HLA typing reportABCDRB1DQB1DPB1F111 2435 1504 0415 1505 0502 26F211 3251 5514 0415 0405 0304 04F311 2435 5504 0415 1505 0526 04F432 1151 1514 0415 0405 0302 04F524 3335 4404 0715 0705 0226 14F611 2435 5504 0415 1505 0504 26F711 2435 5504 0415 1505 0504 26F824 3251 3514 0404 1503 0526 04F911 3251 5514 0415 0405 0304 04F1011 3344 5207 1211 0702 0304 13F1111 3344 5207 1211 0703 0304 13Fig. 1Conclusion:The risk alleles A*24, 32; B*35; DRB1*11 were found to be associated with North Indian cohort of SSc, while the protecting alleles were A*68; DRB1*10, 12.These risk alleles were present in the SSc affected family members and the protective alleles were absent in the same. Surprisingly, even healthy members carried the same risk alleles but did not manifest the disease or have serological evidence of the same. We have not excluded occurrence of disease at a later age, as presently the healthy siblings are young. Thus our study indicates that though HLA association are found with SSc but many other factors like HLA (HLA *C, DPB1*) or non HLA genes as wells as epigenetic factors might also play a role in disease manifestation and severity.References:[1]Luo Y, Wang Y, Wang Q,et al. Systemic sclerosis: genetics and epigenetics. J Autoimmun.2013; 41:161–67.[2]de Juan MD1, Belzunegui J, Belmonte I, Barado J, Figueroa M, Cancio J, Vidal S, Cuadrado E. An immunogenetic study of familial scleroderma. Ann Rheum Dis. 1994 Sep; 53(9):614-7.Acknowledgments:The technical help of Mr.Manoj Kumar and Mr.Vinkesh are hereby gratefully acknowledged Indian Council of Medical Research(Funding of Fellowship)Disclosure of Interests:None declared

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Muchesa, P., O. Mwamba, T. G. Barnard, and C. Bartie. "Detection of Free-Living Amoebae Using Amoebal Enrichment in a Wastewater Treatment Plant of Gauteng Province, South Africa." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/575297.

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Free-living amoebae pose a potential health risk in water systems as they may be pathogenic and harbor potential pathogenic bacteria known as amoebae resistant bacteria. Free-living amoebae were observed in 150 (87.2%) of the environmental water samples. In particular,Acanthamoebasp. was identified in 22 (12.8%) using amoebal enrichment and confirmed by molecular analysis. FLA were isolated in all 8 stages of the wastewater treatment plant using the amoebal enrichment technique. A total of 16 (9.3%) samples were positive for FLA from influent, 20 (11.6%) from bioreactor feed, 16 (9.3%) from anaerobic zone, 16 (9.3%) from anoxic zone, 32 (18.6%) from aerators, 16 (9.3%) from bioreactor effluent, 11 (6.4%) from bioreactor final effluent, and 45 (26.2%) from maturation pond. This study provides baseline information on the occurrence of amoebae in wastewater treatment plant. This has health implications on receiving water bodies as some FLA are pathogenic and are also involved in the transmission and dissemination of pathogenic bacteria.

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Temniskova-Topalova, Dobrina, and Nadja Ognjanova-Rumenova. "Description, comparison and biostratigraphy of the nonmarine Neogene diatom floras from Southern Bulgaria." Geologica Balcanica 27, no. 1-2 (August 30, 1997): 57–81. http://dx.doi.org/10.52321/geolbalc.27.1-2.57.

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The diatom flora from Neogene lake basins in South Bulgaria is summarized and analysed. It consists of 627 species, varieties and forms, wich are distributed as follows: 459 species, 141 varieties and 27 forms (with uncleared nomenclature are 32 species). The species are referred to 51 genera, 23 families, 7 orders and 2 classes. During the Late Miocene - Early Pliocene in the South Bulgarian basins two types of diatom floras developed: I. "Aulacoseira species" type (The floras from Gotse Delchev, Elhovo and Palakariya Basins) and II. "Actinocyclus species" type (The floras from Sofia and Karlovo Basins). Specific type for the Southbulgarian palaeobasins is the "Actinocyclus species" type. The Actinocyclus species as a component of the Miocene floras, are very widespread (China, Far East, Siberia, Europe and North America), but development during the Late Miocene of various species Actinocyclus massively overlapped was observed only in South Bulgaria and to some extent in the Balkan Peninsula.

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M. Muad, Anuar, Siti Khadijah Mohd. Zaki, and Sarah Abbood Jasim. "Optimizing Hopfield Neural Network for Super-Resolution Mapping." Jurnal Kejuruteraan 32, no. 1 (February 28, 2020): 91–97. http://dx.doi.org/10.17576/jkukm-2020-32(1)-11.

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Remote sensing is a potential source of information of land covers on the surface of the Earth. Different types of remote sensing images offer different spatial resolution quality. High resolution images contain rich information, but they are expensive, while low resolution image are less detail but they are cheap. Super-resolution mapping (SRM) technique is used to enhance the spatial resolution of the low resolution image in order to produce land cover mapping with high accuracy. The mapping technique is crucial to differentiate land cover classes. Hopfield neural network (HNN) is a popular approach in SRM. Currently, numerical implementation of HNN uses ordinary differential equation (ODE) calculated with traditional Euler method. Although producing satisfactory accuracy, Euler method is considered slow especially when dealing with large data like remote sensing image. Therefore, in this paper several advanced numerical methods are applied to the formulation of the ODE in SRM in order to speed up the iterative procedure of SRM. These methods are an improved Euler, Runge-Kutta, and Adams-Moulton. Four classes of land covers such as vegetation, water bodies, roads, and buildings are used in this work. Results of traditional Euler produces mapping accuracy of 85.18% computed in 1000 iterations within 220-1020 seconds. Improved Euler method produces accuracy of 86.63% computed in a range of 60-620 iterations within 20-500 seconds. Runge-Kutta method produces accuracy of 86.63% computed in a range of 70-600 iterations within 20-400 seconds. Adams-Moulton method produces accuracy of 86.64% in a range of 40-320 iterations within 10-150 seconds.

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Ueno, H., T. Okusaka, J. Furuse, H. Ishii, N. Saijo, Y. Saito, J. Sawada, H. Sakamoto, T. Yoshida, and Y. Sato. "Use of a genome-wide association study to detect candidate polymorphisms associated with overall survival in stage IV pancreatic adenocarcinoma patients receiving gemcitabine monotherapy." Journal of Clinical Oncology 27, no. 15_suppl (May 20, 2009): 4611. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.4611.

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4611 Background: Individual variations in overall survival time (OS) or antitumor effects may be partly explained by host genetic factors, which have not yet been identified. We performed a genome-wide association study (GWAS) in Japanese patients with stage IV pancreatic adenocarcinoma receiving gemcitabine (Gem) monotherapy. Methods: Metastatic pancreatic ductal adenocarcinoma patients who had previously received neither radiation nor chemotherapy were eligible in this study. Gem was administered as a 30-min i.v. infusion at either 800 or 1000 mg/m2. The peripheral blood leukocyte DNA samples were genotyped at 110,000 SNPs using Illuimina's Human-1 Genotyping BeadChip. Statistical analyses were performed by the log-rank test and Cox proportional hazards model in consideration of linkage disequilibrium. Results: From Jul 2002 to Jul 2006, 67 patients (male/female: 44/23, PS 0/1/2: 31/32/4, 36–78 (median: 62) years of age were enrolled. The median survival time (MST) of these 67 patients was 5.8 months. In the GWAS, we detected 11 candidate SNPs which were associated with significantly shortened OS. Eventually, 6 SNPs were MAF>5% and remained statistically significant even after multiple comparison adjustment: rs1861674 in the LOH12CR1 gene (MST for CC [n=60] and CT [n=7] + TT [n=0] were 6.4 and 1.6 months, respectively; P=1.0×10-7, HR=8.25 (3.3–20.9)), rs10504551 in the TCEB1 (MST for CT [n=28] + CC [n=36] and TT [n=3] were 5.8 and 1.0 months. P=1.1×10-7, HR=14.9 (3.9–56.1)), rs1132750 (MST for AC [n=18] + AA [n=45] and CC [n=4] were 6.3 and 1.1 months. P=4.6×10-11, HR=23.5 (6.1–91.7)), rs2055943 in the GABRA4 (MST for AC [n=27] + CC [n=36] and AA [n=4] were 6.3 and 1.2 months. 1.3×10-11, HR=26.1 (6.4–107), rs2589506 in the MAPK10 (MST for AG [n=29] + GG [n=31] and AA [n=7] were 6.4 and 1.1 months. P=3.2×10-6, HR=5.9 (2.6–14.1)) and rs2586404 in the DNM3 (MST for CT [n=30] + CC [n=33] and TT [n=3] were 5.8 and 0.62 months. P=3.4×10-9, HR=18.6 (4.9–71.5)). Conclusions: GWAS is a powerful tool to search for new prognostic biomarkers for patients with stage IV pancreatic adenocarcinoma receiving Gem monotherapy and may reveal as yet unexplored molecular pathways which correlate with drug response. [Table: see text]

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Djamdjian, Laura, Thierry Naas, Didier Tandé, Gaelle Cuzon, Catherine Hanrotel-Saliou, and Patrice Nordmann. "CTX-M-93, a CTX-M Variant Lacking Penicillin Hydrolytic Activity." Antimicrobial Agents and Chemotherapy 55, no. 5 (February 22, 2011): 1861–66. http://dx.doi.org/10.1128/aac.01656-10.

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ABSTRACTExtended-spectrum β-lactamases (ESBLs) of the CTX-M type are increasingly being reported worldwide, with more than 90 known variants. ClinicalEscherichia coliisolate Bre-1 was isolated in 2009 and displayed an unusual ESBL phenotype, made of a synergy image between expanded cephalosporins and clavulanic acid discs and susceptibility to penicillins.E. coliBre-1 harbored a novel CTX-M-encoding gene, designatedblaCTX-M-93. CTX-M-93 differed from CTX-M-27 by only a single L169Q substitution. Compared to CTX-M-27, CTX-M-93 conferred higher MICs of ceftazidime forE. coli(MIC of 8 versus 1.5 μg/ml) and decreased MICs of other expanded-cephalosporins (MIC of cefotaxime of 1 versus 32 μg/ml) and penicillins (MIC of ticarcillin of 0.5 versus >256 μg/ml). A comparison of enzymatic properties revealed that the L169Q substitution led to a decreasedKmfor ceftazidime (25.5 versus 330 μM) but decreased hydrolytic activity against good substrates, such as cefotaxime (kcatof 0.6 versus 113 s−1), probably owing to the alteration of the omega loop positioning during the catalytic process. TheblaCTX-M-93gene was surrounded by the ISEcp1and IS903elements and inserted onto a 150-kb non-self-transferrable IncF-type plasmid.E. coliBre-1 belongs to phylogroup D and is of multilocus sequence type (MLST) 624, a sequence type found only in rare Spanish CTX-M-14-producingE. coliisolates. We have characterized a novel CTX-M variant, CTX-M-93, lacking significant penicillin hydrolysis but with increased ceftazidime hydrolysis.

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Evdokimova, E. M. "EBRD ACTIVITIES IN THE FIELD OF SUSTAINABLE ENERGY." MGIMO Review of International Relations, no. 5(32) (October 28, 2013): 131–38. http://dx.doi.org/10.24833/2071-8160-2013-5-32-131-138.

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The article focuses on one of the strategic European Bank for Reconstruction and Development (EBRD) sector priorities – sustainable energy. A vast amount of initiatives aiming at efficient energy use have been launched since the late XX century. Among others a pivotal role play the EBRD programmes comprising investments and technical assistance. Within over 20 years of activity the EBRD has gained great experience carrying out projects in the field of energy efficiency and therefore Sustainable Energy Initiative (SEI) was launched in 2006. Sub-sector breakdown include cleaner energy production, industrial energy efficiency, renewable energy, sustainable energy financing facilities for small and medium-scale projects implemented through local banks etc. SEI Phase 1 and 2 had been carried out by the end of 2011. In 2006-2012 the EBRD invested €11 billion in more than 620 projects. In 2012 Phase 3 was launched for the period 2012-2014, financing target – €4,5 to €6,5 billion. SEI accounts for 20-30% of the total EBRD financing volume. The greatest share as a core country of operations receives Russia: total SEI investments – €2,4 billion, number of projects – over 100, avoided greenhouse gases emissions – 18 million tonnes (CO2 equivalent per year), energy savings – 9 million tonnes of oil equivalent per year. Thus the EBRD encourages sustainable low-carbon economic development of the country. The EBRD will further extend sustainable energy activities, combining investments with technical assistance and policy dialogue.

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Corash, Laurence, Fabrice Cognasse, Jean-Claude Osselaer, Natalie Messe, Maryse Van Hooydonk, and Olivier Garraud. "Cytokines in Platelet Components Associated with Acute Transfusion Reactions: The Role of sCD40L." Blood 108, no. 11 (November 16, 2006): 952. http://dx.doi.org/10.1182/blood.v108.11.952.952.

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Abstract Background. Acute transfusion reactions (ATR) have been attributed to antibodies directed against HLA antigens in platelet components (PLT). Cytokines and chemokines, released from PLT during storage are postulated to mediate ATR, clinical refractoriness, and graft vs. host disease. Reduced plasma levels and leuko-depletion of PLT lower the frequency of some, but not all, ATR and allo-immunization. Among platelet factors, soluble CD40L (sCD40L) plays a key role in immunology. CD40/CD40L are strongly expressed by activated platelets and CD40L is cleaved to sCD40L. More than 95% of sCD40L in blood is derived from platelets. CD40 is a major regulator of cellular immune interactions and CD40L stimulates monocytes and T cells, suggesting a pleiotropic role for CD40L. Prior studies suggest sCD40L with other mediators are responsible for ATR, especially fever. Aims. As part of a safety study to monitor ATR for PLT prepared with pathogen inactivation, we identified transfusions associated with ATR. Implicated PLT were sampled to characterize cytokine/chemokine profiles in comparison to PLT not associated with ATR(control). Methods. PLT were collected by apheresis at the Mont Godinne Blood Transfusion Center (BTCMG) with process leuko-reduction, suspended in 35% donor plasma and 65% additive solution (Intersol, Baxter, France) and treated with 150uM amotosalen and 3 J/cm2 UVA for pathogen inactivation (INTERCEPT, Cerus, Concord, CA). Treated PLT were stored up to 7 days until issued for transfusion. Transfusion of PLT required completion of a case report form to monitor the response to transfusion. PLT implicated in ATR were sampled to determine cytokine profiles. Frozen samples (−20 °C) of PLT were sent to EFS Auvergne Loire to assay CD62p(ng/mL), PDGF-AB(ng/mL), IL8(pg/mL), and sCD40L(pg/mL) by specific enzyme linked immunosorbent assays in platelets (plt) and supernatant (s) fractions isolated from the implicated PLT. Cytokine levels in PLT without ATR (Control) were measured in 10 PLT after 5 and 7 days of storage (5d CTL; 7d CTL). Results. In the 18-months after adoption of INTERCEPT PLT compared to the 18-months prior, ATR decreased from 1.3% to 0.9% of transfusions (n = 7,580: Blood2005;106(11):29a). After initiation of the current study, 4 transfusions with ATR had samples available: one with 4-day old PLT (0451) and 3 with 7-day old PLT (0715, 0561, 0536). Supernatants of PLT implicated in ATR contained higher sCD40L levels compared to Control PLT (Table). Increased sCD40L levels in supernatants of PLT implicated in ATR correlated with decreased levels in plt lysates. Levels of IL8, CD62p and PDGFAB, were similar to Control values. Conclusions. In this pilot study, sCD40L was elevated in supernatants and decreased in the platelets of PLT associated with ATR. Other cytokines (CD62p, PDGF, and IL8) were not consistently altered in PLT implicated in ATR. Parameter 5d CTL ATR0451 7d CTL ATR0715 ATR0561 ATR0536 CD62p-S 115 104 119 105 95 92 CD62p-P 141 109 139 61 114 105 PDGF-S 15.8 26.8 17.5 N a 20.1 21.6 PDGF-P 24.9 31.3 23.2 N a 23.1 20.5 sCD40L-S 237 321 201 1024 626 337 sCD40L-P 474 32 314 0 0 44 IL8 -S 117 131 120 131 132 133 IL8-P 117 132 120 131 131 140

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Builes Barrera, Carlos Alfonso. "¿Es necesaria la medición de la T3 para el diagnóstico de hipotiroidismo primario?" Revista Colombiana de Endocrinología, Diabetes & Metabolismo 2, no. 3 (March 27, 2017): 22–24. http://dx.doi.org/10.53853/encr.2.3.91.

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El objetivo de este estudio es evaluar el papel de la T3 en la valoración o diagnóstico de pacientes con hipotiroidismo primario.Se evaluaron 206 registros de pacientes. El 31,6% fueron hombres y el 68,4% mujeres. La edad promedio fue de 46,2, para los hombres 47,8 ±16,6 (rango entre 16 y 87 años) y para las mujeres 45,5±17,5 (rango entre 17 y 83). El valor promedio de TSH fue 75,3± 89 mUI/L (rango entre 10,5 y 490).En los pacientes con TSH entre 10 y 19,9 mUI/L, los valores de T4 libre estuvieron por debajo del rango normal en 31,2%, con un promedio de 0,77±0,06 ng/dl y con un valor promedio de TSH de 17,36 mUI/L. En este grupo (n=48 pacientes), todas las mediciones de T3 (libre o total) estuvieron dentro del rango normal.Los valores bajos de T3 se encontraron en 78 de 206 pacientes (37,8%), cuyo valor promedio de TSH fue 136±115 en el grupo de T3 libre (46 de 124) y 124±123 mUI/L en el grupo de T3 total (32 de 82). En cinco pacientes (6,4%) se encontró T3 baja, con T4 libre dentro del rango normal de referencia, con un valor promedio de TSH de 28,1±11,9 mUI/L, promedio de T4 libre 1,07±0,02 ng/dl.Se confirma la falta de utilidad de medir la T3 en el diagnóstico del hipotiroidismo primario. Los valores bajos de T3 se encontraron en aquellos pacientes con hipotiroidismo primario avanzado (TSH promedio de 136 mUI/L)Abstract The objective of this study is to evaluate the role of T3 in the evaluation or diagnosis of patients with primary hypothyroidism. Two hundred and six patients with primary hypothyroidism were included in the study. 31.6% were male and 68.4% were female. The mean age was 46.2 years for men 47.8 ±16.6 (range 16-87 years) and for women 45.5±17.5 (range 17-83). The mean value of TSH was 75.3± 89 mUI/L (between 10.5 y 490). In the group of patients with TSH level between 10 and 10.9 mUI/L the T4 was low in 31.2%, with a median of 0.77±0.06 ng/ dl, and mean TSH value of 17.36 mUI/L. In that group (n: 48) the T3 measurements was normal in all patients. Low T3 was found in 78 of 206 patients (37.8%), with a mean of TSH of 136±115 in the free T3 group (46 of 124) and mean TSH: 124±123 mUI/L in the total T3 group (32 de 82). In 5 patients (6.4%) we found low T3 with normal free T4 with a mean TSH of 28.1±11.9 mUI/L, free T4 mean 1.07±0.02 ng/ dl. This study confirms the lack of utility of measurement of T3 for the diagnosis of primary hypothyroidism. Low T3 levels were found in cases of severe hypothyroidism ( mean TSH: 136 mUI/L).

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Masiak, A., M. Ziętkiewicz, A. Dębska-Ślizień, and Z. Zdrojewski. "POS0120 INCIDENCE OF MALIGNANCIES IN PATIENTS WITH GRANULOMATOSIS WITH POLYANGIITIS AND MICROSCOPIC POLYANGIITIS DIAGNOSED BETWEEN 1988 AND 2020." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 271. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3840.

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Background:Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a group of systemic necrotizing small vessel vasculitides. Microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) are two most common types of AAV affecting mainly middle-aged and elderly people. Previous data indicated an increased occurrence of cancer in AAV patients [1], which has been mainly attributed to exposure to cyclophosphamide [2].Objectives:The purpose of this paper was to analyze cancer incidence in unselected patients with GPA and MPA treated in one academic center since 1988 with follow-up until 2020.Methods:With case record review, the baseline characteristics, outcomes and malignancy development in a cohort of 251 patients were assessed. Patients were followed up from time of diagnosis to their death or most recent hospital or outpatient’s assessment.Results:Twenty-eight of 251 patients with AAV (65 % cANCA, 26% pANCA, 9.0 % ANCA-negative) developed a total of 32 malignancies during a mean follow-up of 8.6 years. Patients characteristic is presented in table 1. Mean time since AAV onset to cancer diagnosis was 5.86±6.78 years. Of these malignancies, 2 melanoma, 6 were non-melanoma skin cancers, 4 gastrointestinal tract cancer (2 colon, 1 stomach, 1 liver), 3 bladder cancer, 2 breast cancer, 2 uterine cancer, 1 ovarian cancer, 2 prostate cancer, 1 testis cancer, 2 lung cancer, 6 haematological malignancies (1 lymphoma, 1 chronic myeloid leukemia, 4 monoclonal gammopathy of unknown significance), additionally 1 benign salivary gland tumor was found. Four of the 16 patients with renal transplants developed a total of 6 malignancies. There were no differences in the incidence of cancer by gender, age, severity and activity of the disease, ANCA status, smoking status, number of relapses and treatment. There was no association between cancer and cumulative dose of cyclophosphamide.Conclusion:In the AAV group, 11% of patients developed different type of cancer. The most common was non-melanoma skin cancer. The risk of developing malignancy increased with follow-up time. We found no association of tumor development and cumulative cyclophosphamide dose.References:[1]Rahmattulla et al. Incidence of malignancies in patients with antineutrophil cytoplasmic antibody-associated vasculitis diagnosed between 1991 and 2013. Arthritis Rheum. 2015;67(12):3270–3278.[2]Faurschou M et al. Prolonged risk of specific malignancies following cyclophosphamide therapy among patients with granulomatosis with polyangiitis. Rheumatology (Oxford) 2015; 54:1345–1350.Table 1.Characteristics of the AAV patients included in the study.Total sample (n=251)No malignancy occurrence (n=223)Malignancy occurrence (n=28)P valueAge at diagnosis, mean ± SD years53.0±15.952.4±16.457.9±9.45NSFemale, n (%)115 (45.8%)106 (47.5 %)9 (32.1 %)NSMean observation time (years)5.72±5.175.35±4.938.61±6.170.002BVASv318.9±8.4918.9±8.4618.6±8.90NSDEI7.03±2.867.04±2.906.96±2.62NSOrgan involvement, n (%) Upper respiratory tract170 (67.7 %)151 (67.7 %)19 (67.9 %)NS Lungs163 (64.9 %)142 (63.7 %)21 (75.0 %)NS Kidney171 (68.1 %)151 (67.7 %)20 (71.4 %)NS Skin62 (24.7 %)54 (21.5 %)55 (24.7 %)49 (22.0 %)7 (25.0 %)NS Eyes11 (4.4 %)11 (4.9 %)5 (17.9 %)NS Heart30 (12.0 %)24 (10.8 %)0 (0.0 %)NS Gastrointestinal tract34 (13.5 %)32 (14.3 %)6 (21.4 %)NSFollow-up 0–5 years145 (57.8 %)136 (61.0 %)9 (32.1 %)0.004 > 5–10 years62 (24.7 %)52 (23.3 %)10 (35.7 %)NS > 10 years44 (17.5 %)35 (15.7 %)9 (32.1 %)0.031Deaths, n(%)56 (23.0 %)45 (20.8 %)11 (39.3 %)0.029Renal transplantation, n(%)16 (6.4 %)12 (5.4 %)4 (14.3 %)NSCumulative Cyclophosphamide dose (g)14.7±30.014.5±30.816.6±23.6NSDisclosure of Interests:None declared

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Asdaghi, Negar, Dileep R. Yavagal, Kefeng Wang, Nils Mueller-Kronast, Nirav Bhatt, Hannah E. Gardener, Carolina M. Gutierrez, et al. "Patterns and Outcomes of Endovascular Therapy in Mild Stroke." Stroke 50, no. 8 (August 2019): 2101–7. http://dx.doi.org/10.1161/strokeaha.118.023893.

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Background and Purpose— We aimed to evaluate the current practice patterns, safety and outcomes of patients who receive endovascular therapy (EVT) having mild neurological symptoms. Methods— From Jan 2010 to Jan 2018, 127,794 ischemic stroke patients were enrolled in the Florida-Puerto Rico Stroke Registry. Patients presenting within 24 hours of symptoms who received EVT were classified into mild (National Institutes of Health Stroke Scale [NIHSS] ≤5) or moderate/severe (NIHSS>5) categories. Differences in clinical characteristics and outcomes were evaluated using multivariable logistic regression. Results— Among 4110 EVT patients (median age, 73 [interquartile range=20] years; 50% women), 446 (11%) had NIHSS ≤5. Compared with NIHSS >5, those with NIHSS ≤5 arrived later to the hospital (median, 138 versus 101 minutes), were less likely to receive intravenous alteplase (30% versus 43%), had a longer door-to-puncture time (median, 167 versus 115 minutes) and more likely treated in South Florida (64% versus 53%). In multivariable analysis younger age, private insurance (versus Medicare), history of hypertension, prior independent ambulation and hospital size were independent characteristics associated with NIHSS ≤5. Among EVT patients with NIHSS ≤5, 76% were discharged home/rehabilitation and 64% were able to ambulate independently at discharge as compared with 53% and 32% of patients with NIHSS >5. Symptomatic intracerebral hemorrhage occurred in 4% of mild stroke EVT patients and 6.4% in those with NIHSS >5. Conclusions— Despite lack of evidence-based recommendations, 11% of patients receiving EVT in clinical practice have mild neurological presentations. Individual, hospital and geographic disparities are observed among endovascularly treated patients based on the severity of clinical symptoms. Our data suggest safety and overall favorable outcomes for EVT patients with mild stroke.

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Aledort, Louis, Diana Beardsley, Herbert Cooper, George Davignon, Bruce Ewenstein, Gerald Gilchrist, Joan Gill, et al. "Home Treatment of Mild to Moderate Bleeding Episodes Using Recombinant Factor VIIa (Novoseven) in Haemophiliacs with Inhibitors." Thrombosis and Haemostasis 80, no. 12 (1998): 912–18. http://dx.doi.org/10.1055/s-0037-1615388.

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SummaryObjective. To assess the safety and efficacy of a fixed dose of recombinant activated factor VII (rFVIIa; NovoSeven™) in the home setting for mild to moderately severe joint, muscle, and mucocutaneous bleeding episodes in patients with haemophilia A or B with inhibitors. Design. Multicentre, open-label, single arm, phase III study of one year duration. Methods. Patients or their caregivers administered up to three doses of rFVIIa (90 μg/kg i.v.) at 3 h intervals within 8 h of the onset of a mild to moderate bleeding episode. Once the subject considered that rFVIIa had been “effective” with regard to haemostasis (after 1-3 injections), one further (maintenance) dose of rFVIIa was administered. Results. Of 60 patients enrolled, 56 experienced at least one bleed, and 46 completed the one year study. 614 of 877 bleeds (70%) were evaluable according to protocol definitions. Haemostasis was rated as “effective” in 92% (566/614) of evaluable bleeds after a mean of 2.2 injections. For successfully treated episodes, the time from onset of bleeding until administration of the first injection was 1.1 ± 2.0 h (mean ± SD). Twenty-four hours after initial successful response, haemostasis was reported as having been maintained in 95% of cases. Efficacy was comparable for muscle, joint and target joint, and muco-cutaneous bleeding episodes. In an intent-to-treat analysis of all 877 bleeding events, efficacy outcomes were equivalent to the evaluable bleeds, with an effective response in 88% of treated episodes. Treatment-related adverse events occurred in 32 (3% of all) bleeding episodes and consisted of re-bleeds/new bleeds in more than 50% (18/32) of these events. A single episode of superficial thrombophlebitis was the only thrombotic complication encountered, and there were no patient withdrawals due to adverse events. Development of FVII(a) antibodies could not be detected, and hypersensitivity reactions to rFVIIa were not reported. Conclusion. rFVIIa is effective and well tolerated when used in the home setting to treat mild to moderate bleeding episodes in patients with haemophilia A or B with inhibitors.

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Conroy, D. A., A. Mooney, D. Pace, S. Balstad, K. Dubuc, A. Yang, A. Furgal, A. Sen, and J. Arnedt. "0513 Comparison of Patient Satisfaction and Therapeutic Alliance for Telemedicine vs. Face-to-Face Delivered Cognitive Behavioral Therapy for Insomnia." Sleep 43, Supplement_1 (April 2020): A196—A197. http://dx.doi.org/10.1093/sleep/zsaa056.510.

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Abstract Introduction CBT for insomnia (CBTI) is effective but a barrier to its widespread use is the lack of evidence-based delivery modalities other than face-to-face. The perception and acceptability of telemedicine for the delivery of CBTI is unknown. We conducted a randomized controlled non-inferiority trial comparing face-to-face (F2F) and telemedicine (via AASM SleepTM) delivery of CBTI. We compared measures of patient satisfaction with treatment and the perception of the therapist’s warmth and skills between F2F and SleepTM. Methods Adults with insomnia were recruited from insomnia clinics and the community and screened for sleep, medical, and mental health disorders. Eligible participants were randomized to receive CBTI either via AASM SleepTM or F2F in 6 weekly sessions of 45-60 minutes each. Participants completed the Client Satisfaction Questionnaire (CSQ-8) and The Therapy Evaluation Questionnaire (TEQ) after completing treatment. The CSQ-8 score ranges from 8-32 with high scores indicating greater satisfaction. We also analyzed the two items on the TEQ that assess participants’ perception of therapist’s warmth and skills. Item scores ranged from 1-7, with higher scores indicating greater warmth and skills. Results Sixty-five adults with chronic insomnia were recruited primarily from insomnia clinics. Sixty-two participants (41 women, mean age 48.9 ± 15.4 years) completed all 6 sessions of CBTI via F2F (n=32) or via AASM SleepTM (n=30). Independent samples t-tests revealed no significant differences between conditions on patient satisfaction (SleepTM, 28.5 +/-4.2 vs F2F 29.9 +/-2.4, t(-1.5), p=.14), therapist warmth (SleepTM, 6.0 ±1.1 vs F2F, 6.4±0.95, t(-1.4), p=.16), or therapist skills (Sleep TM 6.4 ±1.0 vs F2F, 6.7±0.59, t(-1.5), p=.15). Conclusion Our findings suggest no differences in patient satisfaction, perception of therapist’s warmth, or confidence in therapist’s skills between telemedicine (via the AASM SleepTM) and F2F delivery of CBTI. Telemedicine-delivered CBTI should be implemented more widely. Support Research supported by American Sleep Medicine Foundation Grant # 168-SR-17 (JT Arnedt)

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Borri, Francesco. "Florin Curta, ed., Neglected Barbarians. (Studies in the Early Middle Ages 32.) Turnhout: Brepols, 2010. Pp. xx, 629; 152 black-and-white and 35 color figures. €135. ISBN: 978-2-503-53125-0." Speculum 89, no. 2 (April 2014): 470–71. http://dx.doi.org/10.1017/s0038713414000098.

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Жерко, И. Ю., П. Д. Демешко, Л. В. Науменко, О. А. Гиземова, Е. П. Жиляева, and С. Л. Поляков. "Comparative Analysis of the Immediate Results of Choroidal Melanoma Treatment with Brachytherapy and Stereotactic Radiosurgery." Офтальмология. Восточная Европа, no. 3 (November 8, 2022): 343–52. http://dx.doi.org/10.34883/pi.2022.12.3.025.

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Цель. Оценить уровень локального контроля, частоту осложнений и количество энуклеаций после применения брахитерапии и стереотаксической радиохирургии для лечения первичной меланомы хориоидеи. Материалы и методы. Группа проспективного исследования состояла из пациентов, которым в период с 2019 по 2022 г. была выполнена СРХ (52 пациента). Ретроспективную группу составили 57 пациентов с сопоставимыми размерами опухоли, которым в период с 2017 по 2019 г. была выполнена брахитерапия. Конечными точками исследования были локальный контроль и регистрация осложнений. В обеих группах оценивались следующие постлучевые осложнения: оптикоретинопатия, отслойка сетчатки, гемофтальм, вторичная глаукома. Оценка безметастатической выживаемости проводилась путем построения кривых Каплана – Майера. Результаты. Медиана наблюдения в общей когорте составила 32 месяца. Годичная безрецидивная выживаемость в группе СРХ составила 100%, в группе БТ – 79,9±2,8% (р log-rank = 0,001). Годичная инцидентность оптикоретинопатии в группе СРХ составила 19,5±6,7%, в группе БТ – 15,8±4,8% (p log-rank = 0,29). Годичная инцидентность отслойки сетчатки составила 18,2±6,4% в группе СРХ, 3,5±1,0% в группе БТ (p log-rank = 0,017). Годичная инцидентность вторичной глаукомы в группе СРХ составила 13,0±5,5%, в группе БТ – 1,7±1,1% (p log-rank = 0,003). Уровень сохранения глазного яблока в течение года после лечения составил 89,2±5,1% и 86,3±2,1% после СРХ и БТ соответственно (p log-rank = 0,9). Для категории Т2 годичная беспрогрессивная выживаемость в группе СРХ составила 100,0%, в группе БТ – 98,5±0,8% (p log-rank = 0,159). Для категории Т3 годичная беспрогрессивная выживаемость в группе СРХ составила 100,0%, в группе БТ – 96,4±3,5% (p log-rank = 0,19). Заключение. Требуются дальнейшие исследования для определения группы пациентов, которым целесообразно выполнять СРХ в связи с большей, по сравнению с БТ, частотой осложнений. Purpose. To evaluate the level of local control, the rate of complications and the number of enucleations after the brachytherapy and stereotactic radiosurgery for the treatment of primary choroidal melanoma. Materials and methods. The prospective study group consisted of patients who underwent SRS between 2019 and 2022 (52 patients). The retrospective group consisted of 57 patients with comparable tumor sizes who underwent brachytherapy between 2017 and 2019. The endpoints of the study were local control and registration of complications. In both groups, the following post-radiation complications were assessed: optical retinopathy, retinal detachment, hemophthalmos, secondary glaucoma. Metastatic-free survival was assessed by constructing Kaplan-Meier curves. Results. The median follow-up in the total cohort was 32 months. One-year disease-free survival in the SRS group was 100%, in the BT group it was 79.9±2.8% (p log-rank = 0.001). The 1-year incidence of optical retinopathy in the SRS group was 19.5±6.7%, in the BT group it was 15.8±4.8% (p log-rank = 0.29). The 1-year incidence of retinal detachment was 18.2±6.4% in the SRS group, 3.5±1.0% in the BT group (p log-rank = 0.017). The 1-year incidence of secondary glaucoma in the SRS group was 13.0±5.5%, in the BT group it was 1.7±1.1% (p log-rank = 0.003). The level of preservation of the eyeball during the year after treatment was 89.2±5.1% and 86.3±2.1% after SRS and BT, respectively (p log-rank = 0.9). For category T2, one-year progression-free survival in the SRS group was 100.0%, in the BT group it was 98.5±0.8% (p log-rank = 0.159). For category T3, one-year progression-free survival in the SRS group was 100.0%, in the BT group it was 96.4±3.5% (p log-rank = 0.19). Conclusion. Further studies are required to determine the group of patients who should undergo SRS due to the higher complication rate compared to BT.

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Domínguez Ayala, Maite, Ángel Zorraquino González, Ana Isabel Gutiérrez Ferreras, Mónica Elías Aldama, Patricia Pérez de Villareal Amilburu, Lorena Hierro-Olabarria Salgado, Iker Bengoetxea Peña, and Begoña Roca Domínguez. "Técnica de Browse-Hurst modificada para reparación de eventración de la línea media. Seis años de experiencia en una Sección de Cirugía de la Pared Abdominal." REVISTA HISPANOAMERICANA DE HERNIA 6, no. 1 (January 31, 2018): 38. http://dx.doi.org/10.20960/rhh.65.

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Introducción y objetivos: La reparación de la eventración de línea media con prótesis puede realizarse a diferentes niveles de la pared abdominal. Proponemos describir y evaluar la eficacia del procedimiento de Browse-Hurst modificado (premuscular subaponeurótico) en pacientes con esta patología.Material y método: Estudio retrospectivo de los pacientes intervenidos con esta técnica entre enero de 2010 y diciembre de 2015. La variable principal a estudio fue recidiva de la eventración. Las variables secundarias fueron las siguientes: características los pacientes y de la eventración (tamaño del defecto, localización), días de drenaje y estancia hospitalaria, complicaciones y meses de seguimiento.Resultados: Fueron intervenidos 147 pacientes, con una media de edad de 66 años. Las características de los pacientes son: 32 diabéticos (21.8 %), 39 fumadores (26.5 %), 29 EPOC (19.7 %). El IMC medio fue de 30.6, y la localización del defecto, 67 supraumbilical (48 %), 19 infraumbilical (13.7 %), 32 periumbilical (23 %) y 21 suprainfraumbilical (15.1 %). El tamaño medio fue de 6.4 cm. Hubo una relación significativa entre el tamaño de defecto y la aparición de seroma. El tiempo medio de drenaje fue de 3.9 días, con una estancia hospitalaria media de 4.7 días. La complicación más frecuente fue seroma (11.2 %). La tasa de recidiva de la técnica fue de 4.9 %. El seguimiento en consultas fue de 10.4 meses.Conclusiones: La técnica B-H modificada es segura, eficaz y reproducible. La probabilidad de seroma clínico aumenta significativamente cuando aumenta el tamaño del defecto.

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Jehanzeb, Kanwal, Sajid Ali Shah, Saeed Zaman, Zia Ul Haq, Munir Akmal Lodhi, and Nadeem Ashraf. "A COMPARISON OF MORBIDITY AND MORTALITY AMONG EARLY, MODERATE AND EXTREME PREMATURE INFANTS REPORTING IN GILGIT." Pakistan Armed Forces Medical Journal 70, no. 2 (April 30, 2020): 503–07. http://dx.doi.org/10.51253/pafmj.v70i2.4219.

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Objective: To compare the morbidity and mortality among early, moderate and extreme premature infants reporting in Gilgit. Study Design: Comparative cross sectional study. Place and Duration of Study: Neonatal intensive care unit, Combined Military Hospital, Gilgit, from Jun 2017 to Jun 2018. Methodology: Patients who had completed antenatal visits in Gynae dept and delivered premature babies were recruited in this study. Premature babies from 34 to 37 weeks of gestation are termed as late preterm, 32 to <34 weeks as moderate preterm, with 28 to <32 weeks as very preterm and extreme premature if they are <28 weeks of gestation. The variables which were included in our study were antenatal checkups, period of gestation, weight of baby, period of hospital stay, mode of delivery of oxygen and outcome in terms of being discharged or expired. Results: Number of patients was 101 in this study. Males were 59 (58.4%) and females were 42 (41.6%). Mean weight of study population was 1.81 ± 1.67 kg. Oxygen was given via nasal prongs to 63 (62.4%) patients, via continuous positive airway pressure to 15 (14.9%) patients, via head box to 18 (17.8%) patients and via mechanical ventilation to 5 (5%) patients. 83 (82.2%) babies survived and discharged and 18 (17.8%) expired during hospital stay. Conclusion: Our study concluded that lesser the gestational age, greater is the morbidity and mortality of the preterm babies.

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Breder, V. V., M. Y. Pitkevich, V. Y. Kosirev, B. I. Dolgushin, E. R. Virshke, I. A. Dzhanyan, and K. K. Laktionov. "Predictive Factors for the Effectiveness of Repeated Lines of Transarterial Chemoembolization in the Treatment of Localized Hepatocellular Carcinoma." Journal of oncology: diagnostic radiology and radiotherapy 4, no. 1 (April 12, 2021): 42–52. http://dx.doi.org/10.37174/2587-7593-2021-4-1-42-52.

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Hepatocellular carcinoma (HCC) remains the fourth leading cause of cancer-related death in the world. The progression of HCC after previously effective TACE is quite often local. This article describes our experience with repeated TACE in patients with local progression of HCC. We analyzed 125 patients with HCC, for the period from 2009 to 2015. TACE was performed for intrahepatic manifestations of HCC. Progression of HCC after TACE-1 was observed in 88.8 % (n = 111) patients. Disease progression after TACE‑2 was registered in 40 (32 %) patients. TACE‑3 was performed in 8 (6.4 %) patients. The analysis showed that isolated local intrahepatic progression of HCC with the growth of intrahepatic tumor nodes previously subjected to TACE‑1 (without new foci) does not affect OS. The efficiency of re-embolization (TACE‑2) is somewhat lower than for TACE of the first stage. Independent factors of overall survival increase in patients receiving TACE: satisfactory objective status according to ECOG, efficacy of the first stage of TACE, late progression and objective effect after re-embolization.

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el-Yazigi, A., C. R. Martin, and E. B. Siqueira. "Concentrations of chromium, cesium, and tin in cerebrospinal fluid of patients with brain neoplasms, leukemia or other noncerebral malignancies, and neurological diseases." Clinical Chemistry 34, no. 6 (June 1, 1988): 1084–86. http://dx.doi.org/10.1093/clinchem/34.6.1084.

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Abstract We measured the concentrations of chromium, cesium, and tin in the cerebrospinal fluid (CSF) of 29 patients with brain tumors [21 benign (BBT) and eight malignant (MBT)], 28 leukemic patients, 14 patients with lymphoma or noncerebral solid tumors (NLCT), and 32 control patients (15 with neurological disorders and 17 with noneurological conditions) by use of flameless atomic absorption spectrophotometry. We detected chromium in 94% of the patients, tin in 79%, and cesium in 50%. The mean (and SEM) concentrations (micrograms/L) of these metals in the control group were 4.7 (1.1) for chromium, 3.8 (1.6) for cesium, and 6.4 (1) for tin. We observed significant differences (P less than 0.05) in the concentration of chromium in CSF between the MBT group and all other tumor groups; the ratios for the mean CSF concentration of chromium in patients with BBT, leukemia, or NLCT to that in patients with MBT were 2.6, 2.1, or 4.4, respectively. We saw no significant differences in the concentrations of cesium or tin among the various groups investigated.

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