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Journal articles on the topic '629.735.017 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Dunlop, Hayley, Evelyn Fitzpatrick, Kevin Kurti, et al. "Participation of Patients From Racial and Ethnic Minority Groups in Phase 1 Early Cancer Drug Development Trials in the US, 2000-2018." JAMA Network Open 5, no. 11 (2022): e2239884. http://dx.doi.org/10.1001/jamanetworkopen.2022.39884.

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ImportanceDespite federal initiatives encouraging the enrollment of individuals from racial and ethnic minority groups in US clinical trials, no studies to date have specifically examined demographic disparities among participants in phase 1 drug development trials for patients with metastatic cancer.ObjectiveTo assess trends in the enrollment of patients from racial and ethnic minority groups in US phase 1 therapeutic drug trials for metastatic cancer from 2000 to 2018.Design, Setting, and ParticipantsIn this cross-sectional study, ClinicalTrials.gov was queried in July 2021 to identify compl

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Moore, Beverley A., Kathryn M. Albers, Brian M. Davis, Jennifer R. Grandis, Sandra Tögel, and Anthony J. Bauer. "Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age." American Journal of Physiology-Gastrointestinal and Liver Physiology 292, no. 6 (2007): G1650—G1659. http://dx.doi.org/10.1152/ajpgi.00570.2006.

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Susceptibility to postoperative ileus following abdominal surgery increases with advancing age. The mechanisms underlying this phenomenon are unknown. This study compares functional and molecular endpoints between young-adult (2 mo old), middle-aged (15 mo old), and elderly mice (26–30 mo old) to identify potential mechanisms. Susceptibility to ileus was assessed by measuring gastrointestinal transit (geometric center) 24 h after anesthesia, laparotomy, and light manipulation (LM) of the small bowel. Proinflammatory (IL-6, COX-2, inducible nitric oxide synthase) and anti-inflammatory (IL-10, h

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Krzywicka, Katarzyna, Anita van de Munckhof, Mayte Sánchez van Kammen, et al. "Age-Stratified Risk of Cerebral Venous Sinus Thrombosis After SARS-CoV-2 Vaccination." Neurology 98, no. 7 (2021): e759-e768. http://dx.doi.org/10.1212/wnl.0000000000013148.

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Background and ObjectivesCerebral venous sinus thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) vaccination. Estimated background rate of CVST with thrombocytopenia is 0.1 per million per month. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination.MethodsWe estimated the absolute risk of CVST with and without thrombocytopenia within 28 days of a first dose of 4 SARS-CoV-2 vaccinations using data from the Europea

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Bruni, C., M. Occhipinti, G. Camiciottoli, et al. "OP0181 FUNCTIONAL CUT-OFFS TO DISTINGUISH PULMONARY VASCULAR AND PARENCHYMAL INVOLVEMENT IN SYSTEMIC SCLEROSIS (SSC): A QUANTITATIVE ANALYSIS OF IMAGING FEATURES AT CHEST COMPUTED TOMOGRAPHY (CT)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 112.1–113. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2188.

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Background:Interstitial lung disease (ILD) and pulmonary arterial hypertension represent the most frequent causes of morbidity and mortality in SSc, with chest CT representing the gold standard in ILD assessment, while FVC and DLco allow functional assessment.Objectives:As qualitative analysis of given chest CT scans is hampered by low reproducibility, we aimed to perform a quantitative analysis (QA) of CT scans able to investigate the parenchymal and vascular features in SSc-ILD and thus testing the relationship with clinical-functional data.Methods:We prospectively enrolled 80 patients who u

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Kim, Choo-Won, Alla Godelman, Vineet R. Jain, Avraham Merav, and Linda B. Haramati. "Postlobectomy Chest Radiographic Changes: A Quantitative Analysis." Canadian Association of Radiologists Journal 62, no. 4 (2011): 280–87. http://dx.doi.org/10.1016/j.carj.2010.12.005.

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Purpose To provide a quantative analysis of postlobectomy chest radiographic changes and to evaluate whether the scarring from prior sternotomy affects the size of the hemithorax and the duration of air leak in patients with subsequent lobectomy. Methods In this retrospective case-controlled series, 10 consecutive patients who had a lobectomy after a prior sternotomy and 30 controls, 3 for each case, matched for lobectomy site were identified. Pre- and postoperative chest radiographs were quantitatively analysed for diaphragmic elevation, size of each hemithorax, mediastinal shift, and the pre

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Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis

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Pérez-Stable, Eliseo J., Asmi Panigrahi, Saida I. Coreas, et al. "Diabetes and Hypertension Risk Across Acculturation and Education Levels in Hispanic/Latino Adults." JAMA Health Forum 6, no. 3 (2025): e250273. https://doi.org/10.1001/jamahealthforum.2025.0273.

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ImportanceAcculturation among Hispanic/Latino populations, defined as adaptation to US lifestyle and culture, is often assumed to lead to adverse health outcomes that will reduce the immigrant health advantage.ObjectiveTo evaluate the risks for incident diabetes and hypertension by levels of acculturation and educational attainment.Design, Setting, and ParticipantsThis study used data from the Hispanic Community Health Study/Study of Latinos, a population-based cohort study of men and women aged 18 to 74 years who identified as Central American, Cuban, Dominican, Mexican, Puerto Rican, or Sout

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Qin, Shukui, Zhiguo Hou, Chi Ma, Fangzhou Xia, Ni Guan, and Yuting Chen. "Comprehensive analysis on reactive cutaneous capillary endothelial proliferation following camrelizumab-based therapy in patients with solid tumors: A large-scale pooled analysis of nine phase 2 or phase 3 registration trials." Journal of Clinical Oncology 43, no. 16_suppl (2025): 11037. https://doi.org/10.1200/jco.2025.43.16_suppl.11037.

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11037 Background: Previous studies demonstrated the positive association between cutaneous immune-related adverse events and long-term survival in advanced cancer patients treated with immunotherapy. As a unique adverse event related to camrelizumab, the association of reactive cutaneous capillary endothelial proliferation (RCCEP) with patient prognosis may also exist. Here we comprehensively analyzed the characteristics of RCCEP and this association. Methods: This was a pooled analysis based on individual patient-level data derived from seven phase 3 and two phase 2 registration trials for ne

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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.

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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term antico

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Bizino, Maurice B., Ingrid M. Jazet, Paul de Heer, et al. "Placebo-controlled randomised trial with liraglutide on magnetic resonance endpoints in individuals with type 2 diabetes: a pre-specified secondary study on ectopic fat accumulation." Diabetologia 63, no. 1 (2019): 65–74. http://dx.doi.org/10.1007/s00125-019-05021-6.

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Abstract Aims/hypothesis The aim of this work was to assess the effect of liraglutide on ectopic fat accumulation in individuals with type 2 diabetes mellitus. Methods This study is a pre-specified subanalysis of the MAGNetic resonance Assessment of VICTOza efficacy in the Regression of cardiovascular dysfunction In type 2 diAbetes mellitus (MAGNA VICTORIA) study, with primary endpoints being the effects of liraglutide on left ventricular diastolic and systolic function. The MAGNA VICTORIA study was a single-centre, parallel-group trial in 50 individuals with type 2 diabetes mellitus (BMI >

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Chahoud, Jad, Hagop M. Kantarjian, Farhad Ravandi, et al. "The Impact of 20q Deletion on Clinical Presentation, Treatment Response and Survival in Patients with Acute Myeloid Leukemia (AML): The University of Texas MD Anderson Cancer Center Experience." Blood 126, no. 23 (2015): 1369. http://dx.doi.org/10.1182/blood.v126.23.1369.1369.

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Abstract Background: Karyotype classification is one of the strongest independent prognostic indicators in AML. The majority of recurring chromosomal aberrations are associated with an individual prognosis, other less frequent like the Del (20q), have been minimally evaluated and classified as intermediate risk in AML. Multiple studies established isolated 20q deletion as a good prognostic marker in MDS, with lower AML transformation rates and longer median overall survival (OS) in comparison with complex 20q deletion. Objective: The aim of this study is to determine the frequency and the impa

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Castrejon, I., J. Molina Collada, C. Perez-Garcia, et al. "POS1439 CANCER IN PATIENTS WITH RHEUMATIC DISEASES EXPOSED TO DIFFERENT BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN REAL-WORLD CLINICAL PRACTICE: DATA FROM A MULTICENTER REGISTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3834.

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BackgroundExtensive evidence has confirmed no increased risk of cancer associated to either conventional synthetic DMARDs or anti-TNF in patients with rheumatic diseases. The risk of cancer in biologic (bDMARDs) different to anti-TNF and targeted synthetic (tsDMARDs) is considerably less investigated. As new therapies are emerging, more data in real-world registries are needed to confirm safety in other treatment groups.ObjectivesTo compare the risk of cancer of tsDMARDs and other bDMARDs versus anti-TNF in patients with rheumatic diseases.MethodsData of patients enrolled in BIOBADASER 3.0 up

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Zhang, X., H. Huang, D. Gao, Y. Fan, and Z. Zhang. "OP0283 MYCOPHENOLATE MOFETIL VS CYCLOPHOSPHAMIDE FOR TREATMENT OF LUPUS NEPHRITIS: A SINGLE-CENTER COHORT REAL-WORLD ANALYSIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 188.1–188. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2222.

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BackgroundMycophenolate mofetil (MMF) or low-dose intravenous cyclophosphamide (CYC) are recommended as initial (induction) treatment in many recommendations for the management of lupus nephritis (LN), and randomized controlled trials have shown their similar efficacy. However, there is little to no real-world data.ObjectivesWe conducted the real-world analysis to compare the efficacy and safety of MMF and CYC for the induction treatment of LN.MethodsOur patients came from PKUFH SLE cohort, a single-center longitudinal observational cohort set up in 2007, and only patients received initial rem

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Stölzel, Friedrich, Walter E. Aulitzky, Heinrich Bodenstein, et al. "Risk Stratification Using a New Prognostic Model for Patients with Secondary Acute Myeloid Leukemia - Results of the DSIL-AML96 Trial." Blood 114, no. 22 (2009): 2652. http://dx.doi.org/10.1182/blood.v114.22.2652.2652.

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Abstract Abstract 2652 Poster Board II-628 Background: Secondary acute myeloid leukemia (sAML) following a myelodysplastic syndrome (mdsAML) or deriving as therapy-related AML (tAML) is regarded as an entity with a poor prognosis and patients are normally treated as high risk AML. However due to progress in elucidating the impact of molecular and cytogenetic markers and therefore combining biological and clinical data for prognosis and treatment outcome the aim of this analysis was to provide a prognostic scoring system for this entity by including clinical and laboratory data from patients be

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Квітіньйо Макарена Мартінез, Соріано Федеріко Ґонзало, Яйченко Вірджинія, Стіб Бренда, and Барейро Хуан Пабло. "Predictors of Picture Naming and Picture Categorization in Spanish." East European Journal of Psycholinguistics 6, no. 1 (2019): 6–18. http://dx.doi.org/10.29038/eejpl.2019.6.1.cui.

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The aim of this paper was to identify which psycholinguistic variables are better predictors of performance for healthy participants in a picture naming task and in a picture categorization task. A correlation analysis and a Path analysis were carried out. The correlation analysis showed that naming accuracy and naming latency are significant and positively correlated with lexical frequency and conceptual familiarity variables, whereas they are negatively correlated with H index. Reaction times in the categorization task were negatively correlated with lexical frequency and conceptual familiar

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Regierer, A., A. Weiß, M. Bohl-Buehler, et al. "OP0225 DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 135.2–136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2130.

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Background:Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting the musculoskeletal system as well as skin and nails. The prevalence of depression in psoriasis and PsA is high and ranges from 7-40% [1]. Persistent depressive mood may influence disease activity outcome in PsA, especially patient-reported outcomes.Objectives:To assess the correlation of depressive symptoms with PsA-specific outcome parameters.Methods:RABBIT-SpA is a prospective longitudinal cohort study including PsA patients enrolled at start of a new conventional treatment or b/tsDMARD treatment. In regularly

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Gamis, Alan S., Todd A. Alonzo, Robert B. Gerbing, et al. "Remission Rates In Childhood Acute Myeloid Leukemia (AML) Utilizing a Dose-Intensive Induction Regimen with or without Gemtuzumab Ozogamicin (GO): Initial Results From the Children's Oncology Group Phase III Trial, AAML0531." Blood 116, no. 21 (2010): 182. http://dx.doi.org/10.1182/blood.v116.21.182.182.

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Abstract Abstract 182 Acute Myeloid Leukemia - Therapy, excluding Transplantation: Pediatric and Adult AML Therapy Therapy for childhood AML has evolved in North America over the past decade by pursuing a dose-intensive rather than an intensive-timing strategy. COG AAML0531 was a recently completed Phase III trial that was based upon the MRC AML 12 dose-intensive regimen which reported a complete remission (CR) rate of 93% in their ADE arm with 3% induction (Ind) deaths (Gibson, Blood 100:35a, 2002). While survival outcomes remain “blinded” as the last patients (pts) complete therapy, remissio

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Fitria Budi Utami. "The Implementation of Eating Healthy Program in Early Childhood." JPUD - Jurnal Pendidikan Usia Dini 14, no. 1 (2020): 125–40. http://dx.doi.org/10.21009/141.09.

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   Eating habits develop during the first years of a child's life, children learn what, when, and how much to eat through direct experience with food and by observing the eating habits of others. The aim of this study is to get a clear picture of the Eating program Healthy, starting from the planning, implementation, supervision, and evaluation as a case study of nutrition education; to get information about the advantages, disadvantages and effects of implementing a healthy eating program for children. This research was conducted through a case study with qualitative data an

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Herishanu, Yair, Shai Levi, Neta Goldschmidt, et al. "Efficacy of Front-Line Ibrutinib Versus Fludarabine, Cyclophosphamide and Rituximab (FCR) in Patients with CLL. a Multicenter "Real-World" Study." Blood 138, Supplement 1 (2021): 2641. http://dx.doi.org/10.1182/blood-2021-146848.

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Abstract Introduction: In previously untreated patients with chronic lymphocytic leukemia (CLL), treatment with ibrutinib plus rituximab improved progression-free survival (PFS) and overall survival (OS) compared to the standard fludarabine, cyclophosphamide and rituximab (FCR) chemoimmunotherapeutic regimen, based on the results of the phase III ECOG-E1912 trial. The improvement in PFS with ibrutinib plus rituximab was observed in patients with unmutated immunoglobulin heavy chain variable region gene (IGHV) but not in those with an IGHV mutated profile. However, the efficacy of ibrutinib com

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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Patel, Kamlesh, Nidhi Barot, Ketan Patel, Ambuj Kumar, and Atul Patel. "P437 Diagnostic utility of serum beta D glucan test to prescribe antifungal treatment and its effect on patient's outcome: a study from a tertiary care center in Western India." Medical Mycology 60, Supplement_1 (2022). http://dx.doi.org/10.1093/mmy/myac072.p437.

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Abstract Poster session 3, September 23, 2022, 12:30 PM - 1:30 PM Serum Beta D glucan has 75%-80% sensitivity and 80% specificity to make a diagnosis of invasive candidiasis. Objectives This study was designed to understand real-world diagnostic utility of S. Beta D Glucan (BDG) on antifungal prescription patterns associated patient outcomes. Methods Study design: Retrospective cohort study Study Population: All consecutive patients who underwent BDG (fungitell assay) testing with conclusive (positive or negative) results in the intensive care unit (ICU) setting between January 1, 2021 to Dece

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Sethi, Nitin, Amitabh Dutta, Goverdhan D. Puri, et al. "Evaluation of Quality of Recovery With Quality of Recovery-15 Score After Closed-Loop Anesthesia Delivery System-Guided Propofol Versus Desflurane General Anesthesia in Patients Undergoing Transabdominal Robotic Surgery: A Randomized Controlled Study." Anesthesia & Analgesia, February 26, 2024. http://dx.doi.org/10.1213/ane.0000000000006849.

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BACKGROUND: Robotic technique of surgery allows surgeons to perform complex procedures in difficult-to-access areas of the abdominal/pelvic cavity (eg, radical prostatectomy and radical hysterectomy) with improved access and precision approach. At the same time, automated techniques efficiently deliver propofol total intravenous anesthesia (TIVA) with lower anesthetic consumption. As both above are likely to bring benefit to the patients, it is imperative to explore their effect on postanesthesia recovery. Quality of Recovery-15 (QoR-15) is a comprehensive patient-reported measure of the quali

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Lorenzo, Elizabeth, and Rebecca E. E. Lee. "Abstract 12347: Investigating Correlates of Hypertension Among Primarily Hispanic Women." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.12347.

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Introduction: Under-recognized risk factors (social, economic, cultural, psychological) may contribute to the development of HTN among Hispanic women that warrant investigation. The purpose of this study was to explore the unique contribution of education, food insecurity, household size, Hispanic ethnicity, marital status, neighborhood crime, BMI, waist circumference (WC), and subjective physical activity on HTN, SBP, and DBP on a sample of primarily Hispanic women. Methods: Female guardians ( N = 227, 69.6% Hispanic, 32.7±8.3 years) of preschoolers completed sociodemographic and health histo

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De Rosa, Luigi, Theodore D. Drivas, and Marco Inversi. "On the Support of Anomalous Dissipation Measures." Journal of Mathematical Fluid Mechanics 26, no. 4 (2024). http://dx.doi.org/10.1007/s00021-024-00894-z.

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AbstractBy means of a unifying measure-theoretic approach, we establish lower bounds on the Hausdorff dimension of the space-time set which can support anomalous dissipation for weak solutions of fluid equations, both in the presence or absence of a physical boundary. Boundary dissipation, which can occur at both the time and the spatial boundary, is analyzed by suitably modifying the Duchon & Robert interior distributional approach. One implication of our results is that any bounded Euler solution (compressible or incompressible) arising as a zero viscosity limit of Navier–Stokes solution

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MATSUHASHI, YUKI, TAKAHIRO ABE, TOMOYUKI FUJITA, SHINJI CHIKAZAWA, and YUKIHIRO FUJITA. "907-P: The Effect of Imeglimin on Glycemic Management in Japanese Patients with Type 2 Diabetes." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-907-p.

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Background: Imeglimin exerts hypoglycemic actions by stimulating insulin secretion in a glucose concentration-dependent manner and by improving insulin resistance. We evaluated the effects of imeglimin on glycemic management, insulin secretion, body weight(BW) and composition in Japanese patients with type 2 diabetes. Subjects and Methods: Patients with inadequate glycemic control(HbA1c &gt;7.0%), treated with diet/exercise or oral antidiabetic drugs(OADs) in our outpatient clinic, were eligible. Height, BW and composition were measured and body mass index(BMI) was calculated. Diabetic com

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Krzywicka, Katarzyna, Anita van de Munckhof, Mayte Sanchez van Kammen, et al. "Abstract 51: Age Stratified Risk Of Cerebral Venous Sinus Thrombosis After Sars-Cov-2 Vaccination." Stroke 53, Suppl_1 (2022). http://dx.doi.org/10.1161/str.53.suppl_1.51.

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Introduction: Cerebral Venous Sinus Thrombosis (CVST) as a part of the thrombosis and thrombocytopenia syndrome is a rare adverse drug reaction of SARS-CoV-2 vaccination. The estimated background rate of CVST in adults is around 1 case per million per month, and CVST with thrombocytopenia accounts for 8% of all CVST. We assessed the age-stratified risk of CVST with and without thrombocytopenia after SARS-CoV-2 vaccination. Methods: We estimated the absolute risk of any CVST, CVST with thrombocytopenia, and CVST without thrombocytopenia, within 28 days of first dose SARS-CoV-2 vaccination, usin

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Wu, Lu, Weidong Yu, Chen Cheng, et al. "Integrative indexes reveal the tolerance of winter wheat to different overwinter freezing injury." Frontiers in Plant Science 15 (October 17, 2024). http://dx.doi.org/10.3389/fpls.2024.1419381.

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Winter wheat (Triticum aestivum L.) is a crucial crop that guarantees food supply in the North China Plain (NCP). As the frequency of extreme cold events increases, it is necessary to explore the freezing resistance of different wheat varieties in order to clarify planting boundaries and help with risk assessment. In this study, 2-year controlled experiments were conducted to explore the effect of freezing temperatures (Tair) and freezing durations on three winterness types. A set of indexes were used to characterize the subfreezing stress on wheat tiller, leaf, and final yield. Logistical reg

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Hamaoka, T., H. Murai, H. Sugimoto, et al. "1417Effect of sodium glucose cotransporter 2 inhibitor on sympathetic nerve activity in type 2 diabetes mellitus patients." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz748.0064.

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Abstract Background Diabetes mellitus (DM) is a well-known risk factor for cardiovascular diseases. Augmented sympathetic nerve activity plays an important role in the progressive worsening disease severity. Most of anti-diabetic drugs were demonstrated to not only decrease blood glucose, but also increase sympathetic nerve activity. Recently, it has been reported that sodium glucose cotransporter 2 (SGLT2) inhibitor has beneficial effects on cardiovascular events in spite of the decrease in blood glucose in type 2 DM patients. The underlying mechanisms remain speculative; however, it is assum

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Galli, A., M. Lippolis, E. Barbolini, et al. "P951Autonomic nervous function and excitability of the accessory pathway in pediatric patients with Wolff-Parkinson-White ECG." EP Europace 22, Supplement_1 (2020). http://dx.doi.org/10.1093/europace/euaa162.277.

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Abstract Abrupt loss of preexcitation identifies low-risk Wolff-Parkinson-White (WPW). We hypothesize that the autonomous nervous system (ANS) modulates the conduction of the accessory pathway (AP). PURPOSE To compare heart rate variability (HRV) in children with (WPWi) and without (WPWp) intermittent preexcitation. METHODS The study conforms to the Declaration of Helsinki. 18 WPW children and controls performed ECG Holter for HRV analysis. Intermittent preexcitation was defined as abrupt loss of WPW pattern. Kolmogorov-Smirnov test confirmed normal distribution of data. T-test and Fisher"s ex

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Iglesias, Raúl, Luís Filipe Rangel, Fabio Fernández-Vázquez, Maria João Santos, and José M. García-Estévez. "Morphometric and molecular characterization of Kudoa encrasicoli n. sp. (Myxozoa: Myxosporea) from the European anchovy, Engraulis encrasicolus (L.) (Clupeiformes: Engraulidae)." Systematic Parasitology, July 1, 2022. http://dx.doi.org/10.1007/s11230-022-10051-7.

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AbstractThe European anchovy represents the main fisheries for countries in the Mediterranean and Black Sea basins. The skeletal muscle of 13 of 48 (27.1%) Engraulis encrasicolus (L.) specimens from North East Atlantic waters (FAO 27.8.c) was found infected with interfibrillar elongated plasmodia (130-980 µm in length) containing mature myxospores belonging to the genus Kudoa Meglitsch, 1947. No flesh softening was found associated with infection. Fresh myxospores were 10.8 ± 0.7 (9.1-12.3) µm in width 1, 11.3 ± 0.9 (9.5-13.4) µm in width 2, 6.7 ± 0.4 (5.8-7.4) µm in thickness, and 6.9 ± 0.5 (

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Huo, X. H., H. M. K. Krumholz, X. B. Bai, et al. "P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz747.0184.

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Abstract Background Mobile health interventions hold the prospect to support risk factor and lifestyle modification and are readily scalable in healthcare systems. Purpose We aim to assess whether text messaging program can improve glycemic control in high-risk patients with coronary heart disease (CHD) and diabetes mellitus (DM). Methods The study was a multi-centre randomised clinical trial conducted at 34 clinics in China. 502 individuals with both CHD and DM were recruited and randomly assigned to either the text messaging intervention (n=251) or control group (n=251). The control group re

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Lanteri-Minet, M., R. Fabre, C. Martin, et al. "One-year prospective real-world assessment of effectiveness and safety of erenumab in migraine prevention: results of the French FHU INOVPAIN registry study." Journal of Headache and Pain 24, no. 1 (2023). http://dx.doi.org/10.1186/s10194-023-01680-4.

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Abstract Background Randomized clinical trials have demonstrated efficacy and safety of erenumab. The aim of this study is to evaluate the effectiveness and safety of erenumab in a real-world setting in French patients with migraine associated with extreme unmet needs. Methods This is a one year-prospective real-word study with enrolment of all consecutive adult patients included in the FHU InovPain registry who participated in a compassionate erenumab use program. Results Of 144 patients included, 140 patients (82.1% female / mean age of 50.9 ± 11.4) received at least one dose of erenumab and

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Martin Garcia, A. C., K. Dimopoulos, M. Boutsikou, et al. "P3655Right ventricular volume off-loading following atrial septal defect closure or pulmonary valve replacement: impact on tricuspid regurgitation and mid-term remodeling." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz745.0512.

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Abstract Introduction Cardiac surgery or catheter intervention is nowadays commonly performed to abolish volume loading of the right ventricle (RV) in adults with congenital heart disease (ACHD). Purpose Little is known, however, of their impact on the preexisting tricuspid regurgitation (TR) following such procedures (atrial septal defect [ASD] closure and pulmonary valve replacement [PVR]), which was the aim of our study. Methods Demographics, clinical and echocardiographic characteristics were analyzed from 162 consecutive patients undergoing such interventions between July 2005 and Decembe

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Bove, Virginia, Eloísa Riva, Jule Vásquez, et al. "Epidemiology and Risk Factors for the Development of Infectious Complications in Newly Diagnosed Multiple Myeloma: A Multicenter Prospective Cohort Study in Latin America." JCO Global Oncology, no. 8 (July 2022). http://dx.doi.org/10.1200/go.22.00068.

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PURPOSE Infections are a significant cause of morbidity and mortality in patients with multiple myeloma (MM). In Latin America, data on infectious complications in this patient population are lacking. METHODS We conducted a prospective cohort study of patients with newly diagnosed MM (NDMM) in seven Latin American countries between June 2019 and May 2020. Patients with active disease, on active therapy, and with a follow-up of 6 months from the time of diagnosis were included. Our primary end point was the number of infectious events that required hospitalization for ≥ 24 hours. RESULTS Of 248

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Ma, Emily Z., Hannah R. Chang, Sarah Radtke, and Joy Wan. "Symptoms of Cognitive Impairment Among Children With Atopic Dermatitis." JAMA Dermatology, March 6, 2024. http://dx.doi.org/10.1001/jamadermatol.2024.0015.

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ImportancePrevious studies suggest that atopic dermatitis (AD) is associated with cognitive impairment in children, but these studies have relied primarily on neurodevelopmental diagnoses (rather than symptoms) as proxy measures of cognitive function. It remains unknown if certain subpopulations of children with AD are at greater risk of cognitive impairment.ObjectiveTo examine the association of AD with symptoms of cognitive impairment (difficulty in learning or memory) among US children and whether this association varies according to the presence or absence of neurodevelopmental comorbiditi

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Carboni, L., C. Tondo, A. Rossillo, et al. "Sedation protocols for atrial fibrillation ablation using pulsed-field ablation: patient and operator-reported outcomes from a large nationwide study." Europace 27, Supplement_1 (2025). https://doi.org/10.1093/europace/euaf085.383.

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Abstract Background General anesthesia (GA) or monitored anesthesia with deep sedation (DS) are the preferred sedation protocols used during thermal ablation of atrial fibrillation (AF). However, each approach may have advantages and disadvantages with variability in operator preferences and patient’s feedback. Purpose We aimed to evaluate the procedural workflow of AF ablation using the Farapulse PFA technology, as well as assess patient- and operator-reported outcomes (including primary operator, anesthesiologist, and nursing staff), in procedures performed under GA versus DS, within a large

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Peng, Ying, Huanlian Yang, Weifei Fan, et al. "Real-world effectiveness and safety of ondansetron oral soluble film for the prevention of chemotherapy-induced nausea and vomiting." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e24079.

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e24079 Background: Chemotherapy-induced nausea and vomiting (CINV) are significant adverse effects that compromise patient adherence and quality of life. Ondansetron oral soluble film is a rapidly absorbed formulation that may improve patient convenience and antiemetic adherence. This study aimed to evaluate the real-world effectiveness and safety of ondansetron oral soluble film for CINV prevention. Methods: This multi-center, real-world study included patients undergoing chemotherapy who received ondansetron oral soluble film for at least three days. Dosing was determined based on clinical p

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." May 26, 2021. https://doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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Lurz, J. A. R. "Quality of life and perception after pulmonary vein isolation and app-based mental training - Results from the randomized controlled MENTAL AF Trial." Europace 25, Supplement_1 (2023). http://dx.doi.org/10.1093/europace/euad122.669.

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Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): German Heart Foundation Introduction It was recently shown that app-based mental training (MT) reduces atrial fibrillation (AF) related symptoms as compared to usual care in patients undergoing catheter ablation for AF. We now report the effect of MT on quality of life (QoL) and AF burden. Methods MENTAL AF was a RCT with two parallel treatment groups enrolling patients undergoing catheter ablation for symptomatic AF during August 2019 and July 2021. Patients were randomized in a 1:1-ratio to app-bas

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Colaneri, M., G. Montrucchio, G. Scaglione, et al. "P01. The IMPACT-VAP study: incidence and mortality of ventilator-associated pneumonia in critically ill patients: results from the PROSAFE project." JAC-Antimicrobial Resistance 7, Supplement_2 (2025). https://doi.org/10.1093/jacamr/dlaf046.001.

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Abstract Background Despite preventive measures, ventilator-associated pneumonia (VAP) persists as the most frequent healthcare-associated infection in intensive care units (ICUs),1 with high incidence and mortality rates.2,3 Here, we wanted to study the incidence of VAP in 192 Italian ICUs in the last decade. Secondly, we wanted to describe the clinical and microbiological characteristics. Finally, we wanted to assess the variables associated with their intra-ICU mortality. Methods In this multicentric observational study, data from 192 Italian ICUs were retrieved from the PROSAFE project, a

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Qu, Qiang, Qixin Guo, Jinjing Shi, et al. "Trends in cardiovascular risk factor prevalence, treatment, and control among US adolescents aged 12 to 19 years, 2001 to March 2020." BMC Medicine 22, no. 1 (2024). http://dx.doi.org/10.1186/s12916-024-03453-5.

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Abstract Background Early-life cardiovascular risk factors (CVRFs) are known to be associated with target organ damage during adolescence and premature cardiovascular morbidity and mortality during adulthood. However, contemporary data describing whether the prevalence of CVRFs and treatment and control rates have changed are limited. This study aimed to examine the temporal trends in the prevalence, treatment, and control of CVRFs among US adolescents over the past 2 decades. Methods This is a serial cross-sectional study using data from nine National Health and Nutrition Examination Survey c

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Hong Son, Bui, Vu Van Nga, Le Thi Diem Hong, and Do Thi Quynh. "Potent Natural Inhibitors of Alpha-Glucosidase and the Application of Aspergillus spp. in Diabetes type 2 Drugs: a Review." VNU Journal of Science: Medical and Pharmaceutical Sciences 38, no. 1 (2022). http://dx.doi.org/10.25073/2588-1132/vnumps.4334.

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Diabetes Mellitus has been becoming a disease of the century, and disease incidence is still rising worldwide. It causes many serious complications, especially in the eye, heart, kidneys, brain, and vascular system, such as diabetic nephropathy, diabetic retinopathy, liver failure, etc. Moreover, the process of controlling this disease is complicated. Meanwhile, the antidiabetic drugs on the market are facing some problems with a wide range of adverse reactions. Therefore, finding new drugs to treat diabetes has always been a topic that many researchers are interested in, especially drugs der

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Wilcox, Mark, Dave Heaton, Aruni Mulgirigama, et al. "P18 Treatment patterns and extent of inappropriate antimicrobial treatment among female patients with uncomplicated urinary tract infection in England." JAC-Antimicrobial Resistance 5, Supplement_3 (2023). http://dx.doi.org/10.1093/jacamr/dlad077.022.

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Abstract Background and Objectives Inappropriate antimicrobial treatment of uncomplicated urinary tract infection (uUTI) has potential impacts on healthcare resource use and costs. We characterized treatment patterns for uUTI in England, including the extent of inappropriate treatment. Methods This retrospective cohort study utilized anonymized patient data from the Clinical Practice Research Datalink (CPRD) database from 1 January 2018 to 31 December 2019. Female patients ≥12 years with a diagnosis of community-acquired uUTI (index), who had received ≥1 oral antibiotic within ±5 days of index

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Yakovleva, Natalia M., Alisa M. Shul’ga, Kristina V. Stepanova та ін. "Микроконусные анодно-оксидные пленки на спеченных порошках ниобия". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 1 (2020). http://dx.doi.org/10.17308/kcmf.2020.22/2536.

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Информация об анодировании спеченных порошков (CП) ниобия ограничена изучением роста барьерных пленок. Формирование наноструктурированной анодной оксидной пленки (АОП) на поверхности частиц порошка должно привести к заметному увеличению удельной поверхности образца и росту химической активности материала. В соответствии с вышесказанным, исследование анодного наноструктурирования спеченных порошков ниобия является актуальной задачей, открывая перспективы создания новых функциональных наноматериалов. Цель статьи – изучение процесса анодирования спеченных порошков Nb во фторсодержащем водном элек

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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sprotocols. "A protocol for embryonic stem cell derivation by somatic cell nuclear transfer into human oocytes." December 31, 2014. https://doi.org/10.5281/zenodo.13657.

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Authors: Dieter Egli & Gloryn Chia ### Abstract Here we describe detailed methods that allowed us to derive embryonic stem cell lines by nuclear transfer of fibroblasts from a newborn and from a type 1 diabetic adult. The protocol is based on the insight that 1) agents for cell fusion can act as potent mediators of oocyte activation by compromising maintaining plasma membrane integrity; minimizing the concentration at which they are used, and at least transiently remove calcium from the medium can improve developmental potential. 2) and on the insight that an efficient stimulus for oocyte

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