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1

Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. III 2/4-Nitrophenoxides of Univalent Heavy Metals." Australian Journal of Chemistry 51, no. 8 (1998): 735. http://dx.doi.org/10.1071/c97100.

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Room-temperature single-crystal X-ray studies are recorded for 2- and 4-nitrophenoxide salts of silver(I) and thallium(I), M(2-np) and Tl(4-np) (anhydrous), and Ag(4-np).H2O. Ag(2-np) is monoclinic, P21/c, a 9·012(4), b 5·743(5), c 12·594(5) Å, β 104·34(4)°, Z = 4; conventional R on |F| was 0·042 for No 1378 independent ‘observed’ (I > 3σ(I)) reflections. Tl(2-np) is monoclinic, C2/c, a 27·250(3), b 3·712(1), c 15·147(3) Å, β 114·41(1)°, Z = 8, R 0·025 for No 1346. Ag(4-np).H2O is monoclinic, P21/a, a 5·613(6), b 13·191(7), c 9·844(5) Å, β 92·50(6)°, Z = 4, R 0 ·033 for No 622. Tl(4-np) is
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Fabrikantov, O. L., I. V. Lev, and N. M. Agarkov. "Biomarkers of Allostatic Load in Patients with Diabetic Retinopathy." Ophthalmology in Russia 19, no. 3 (2022): 624–29. http://dx.doi.org/10.18008/1816-5095-2022-3-624-629.

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Diabetic retinopathy occupies a special place among the causes of the progression of decrease and loss of visual acuity, significantly impairing the quality of life and age-related viability, an integral indicator that is considered allostatic load. However, the allostatic load in patients suffering from diabetic retinopathy, as well as in other ophthalmological diseases, has not been practically studied and biomarkers characterizing the allostatic load of patients with diabetic retinopathy remain unknown.Purpose. To study of allostatic load in patients with diabetic retinopathy and the identi
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Ishimoto, Chikako, Tsukasa Sugiyama, Toshimi Matsumoto, Hirohide Uenishi, Yasuyuki Fukumoto, and Miyoko Waki. "Full-scale simultaneous partial nitrification, anammox, and denitrification process for treating swine wastewater." Water Science and Technology 81, no. 3 (2020): 456–65. http://dx.doi.org/10.2166/wst.2020.120.

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Abstract A full-scale swine-wastewater activated sludge treatment plant that contains naturally enriched anammox biofilms was investigated for 2 years. Red biofilm in this system included Planctomycetes at a maximum of 62.5% of the total bacteria diversity, including Candidatus Jettenia and Candidatus Brocadia. The plant was operated with an influent containing 1,104 ± 513 mg/L biochemical oxygen demand (BOD) and 629 ± 198 mg/L total nitrogen (TN) (BOD/N of 1.78 ± 0.58) at a volumetric BOD loading rate of 0.32 ± 0.12 kg/m3/d. Notwithstanding drastically varying influent concentrations, BOD rem
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Glicksman, Rachel, Di Maria Jiang, Philippe Bedard, et al. "Clinical outcomes of stage IIA/IIB seminoma treated with radiotherapy and chemotherapy: Should regional therapy be considered the preferred treatment approach?" Journal of Clinical Oncology 43, no. 5_suppl (2025): 629. https://doi.org/10.1200/jco.2025.43.5_suppl.629.

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629 Background: With the publication of the Surgery in Early Metastatic Seminoma Trial there has been increasing interest in the use of regional therapy as first line treatment (reserving systemic therapy for relapse) in patients with testicular seminoma with low volume with retroperitoneal lymphadenopathy. Herein, we sought to evaluate outcomes with both management approaches. Methods: A prospectively maintained single-institutional database was retrospectively queried for patients diagnosed between 1995-2016 with de novo clinical stage IIA/B (CSIIA/B) or who relapsed on surveillance (Rel-CSI
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Angeles-Han, S., A. Cassedy, T. Hennard, et al. "POS1303 METHOTREXATE RESPONSE IN PEDIATRIC NON-INFECTIOUS UVEITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 989–90. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1473.

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BackgroundChildren with chronic non-infectious uveitis (NIU) are at risk for sight-threatening complications. Methotrexate (MTX) is the preferred first-line systemic treatment. Initial therapeutic response takes 3-6 months to achieve NIU control, leading to prolonged glucocorticoid use. Moreover, at least 50-70% of children fail to fully respond and may accrue ocular damage while awaiting MTX response.ObjectivesTo identify features of children with NIU that are associated with MTX failure.MethodsWe included children who started MTX monotherapy for NIU. We collected demographics, NIU features (
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Levine, Alexander R., Steven M. Lemieux, Daniela D’Aquino, Analise Tenney, Margaret Pisani, and Syed Ali. "Risk Factors for Continuation of Atypical Antipsychotics at Hospital Discharge in Two Intensive Care Unit Cohorts." Clinical Medicine Insights: Psychiatry 10 (January 2019): 117955731986381. http://dx.doi.org/10.1177/1179557319863813.

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Introduction: Atypical antipsychotics are frequently initiated in the intensive care unit (ICU) to treat delirium. Many patients continue on these agents at hospital discharge despite a lack of data to support long-term use. Objectives: The primary aim of this study was to determine underlying risk factors for continuation of antipsychotics at hospital discharge in medical intensive care unit (MICU) and surgical intensive care unit (SICU) patients when evaluated as separate cohorts. Methods: A single-center, retrospective study in patients newly initiated on quetiapine, risperidone, or olanzap
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De Araújo Junior, Francisco Ocian, Leonardo Castelo Branco Carvalho, Flavio de Almeida Alves-Júnior, et al. "Avaliação da saúde nutricional dos pescadores artesanais de uma cidade do litoral amazônico." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 21, no. 8 (2023): 8606–29. http://dx.doi.org/10.55905/oelv21n8-043.

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O presente estudo tem como o objetivo avaliar o perfil epidemiológico da saúde nutricional dos pescadores artesanais da cidade paraense de São Caetano de Odivelas. A coleta de dados ocorreu, entre Agosto e Novembro de 2022, com pescadores artesanais cadastrados e efetivos junto a Colônia de Pescadores Z-4. Participaram do estudo 78 pescadores profissionais membros da colônia com idade entre 20 e 65 anos de ambos os gêneros. O instrumento de coleta foi via questionário socioeconômico e demográfico por meio de ficha de cadastro e acompanhamento nutricional do Sistema de Vigilância Alimentar e Nu
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Chen, Q. H., Y. C. Wang, and X. B. Zheng. "Genetic analysis and molecular mapping of the avirulence gene PRE1, a gene for host-species specificity in the blast fungus Magnaporthe grisea." Genome 49, no. 8 (2006): 873–81. http://dx.doi.org/10.1139/g06-043.

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We analyzed host-species specificity of Magnaporthe grisea on rice using 110 F1 progeny derived from a cross between the Oryza isolate CH87 (pathogenic to rice) and the Digitaria isolate 6023 (pathogenic to crabgrass). To elucidate the genetic mechanisms controlling species specificity in M. grisea, we performed a genetic analysis of species-specific avirulence on this rice population. Avirulent and virulent progeny segregated in a 1:1 ratio on the 2 rice cultivars 'Lijiangxintuanheigu' (LTH) and 'Shin2', suggesting that a single locus, designated PRE1, was involved in the specificity. In a co
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Nickel, J. Curtis, Joe Downey, Francois Bénard, et al. "The Canadian Benign Prostatic Hyperplasia Audit Study (CanBas)." Canadian Urological Association Journal 2, no. 4 (2013): 367. http://dx.doi.org/10.5489/cuaj.629.

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Objective: To determine the prevalence, diagnostic patterns and management of lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in Canadian urology outpatient practice.Methods: Representative urologists were randomly selected from lists provided by the Canadian and Quebec Urological Associations. Each patient identified with a BPH diagnosis during a typical 2-consecutive-week period during April, May or June 2007 was asked to complete a corresponding International Prostate Symptom Score (IPSS) questionnaire. Each day, the participant urologist completed an
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Sepulveda-Rincon, L. P., D. Dube, P. Adenot, et al. "78 NONINVASIVE CELL LINEAGE TRACING IN BOVINE EMBRYOS FROM 2-CELL STAGE UP TO BLASTOCYST STAGE." Reproduction, Fertility and Development 27, no. 1 (2015): 132. http://dx.doi.org/10.1071/rdv27n1ab78.

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The first lineage specification occurs during pre-implantation mammalian development. At the blastocyst stage, 2 cell lineages can be distinguished: the inner cell mass (ICM) and the trophectoderm (TE). The exact timing when embryo cells are skewed to these lineages is not clearly determined in mammalian species. In murine embryos, it has been suggested that the first cleavage plane might be related to the embryonic-abembryonic (Em-Ab) axis at blastocyst stage. Thus, the daughter cells of the 2-cell embryo might already be predisposed to a specific cell lineage further on development. The obje
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Law, Jeanna Wallenta, Zartash Gul, Anna Berry, et al. "Abstract 6259: Molecular biomarker testing and targeted therapy patterns in patients with acute myelogenous leukemia (AML): A real-world data analysis." Cancer Research 82, no. 12_Supplement (2022): 6259. http://dx.doi.org/10.1158/1538-7445.am2022-6259.

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Abstract Background and Objective: Molecular testing and targeted treatments for patients (pts) diagnosed with AML have evolved in recent years. Real-world testing patterns, including next-generation sequencing (NGS), and clinical management of pts with AML were analyzed in 2 large U.S. community health systems. Methods: Pts >18 years, diagnosed with AML from January 1, 2015 to December 31, 2020, were identified in a database containing clinical and genomic data from integrated community delivery networks. Study end was March 31, 2021, allowing for 3 months minimum follow up. Actionable
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Рохман, Б. Б., та С. Г. Кобзар. "КОНСТРУКТИВНІ ОСОБЛИВОСТІ ДОСЛІДНОЇ УСТАНОВКИ ТА ЧИСЛОВІ ДОСЛІДЖЕННЯ ПРОЦЕСУ ТЕРМОХІМІЧНОЇ ПЕРЕРОБКИ БІОМАСИ. ЧАСТИНА 2. АНАЛІЗ ПРОЦЕСУ ПІРОЛІЗУ В АПАРАТІ З ФІКСОВАНИМ ШАРОМ". Vidnovluvana energetika, № 3(78) (30 вересня 2024): 153–65. http://dx.doi.org/10.36296/1819-8058.2024.3(78).153-165.

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З використанням побудованої в першій частині роботи моделі піролізу біомаси проведено дослідження процесу термолізу Bagasse і Wood Birch. Розглядалися різні варіанти прогріву шару за рахунок: а) електронагріву зовнішньої та внутрішньої поверхонь піролізера; б) електронагріву зовнішньої поверхні та обігріву внутрішньої поверхні піролізера продуктами згоряння; в) електронагріву зовнішньої поверхні піролізера та комбінованого обігріву внутрішньої поверхні: у перші 20 с використовується електронагрів, далі − теплова енергія продуктів згоряння з температурою 1300 °С. Показано, що: а) для швидкого п
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Suji, Nur Izzati Ahmad, Aisyah Mardhiah Supian, Muhammad Yazid Jalaludin, et al. "EVALUATING OUTCOMES OF CHILDHOOD OBESITY MANAGEMENT: A 2-YEAR FOLLOW-UP STUDY." Journal of the ASEAN Federation of Endocrine Societies 40, S1 (2025): 142–43. https://doi.org/10.15605/jafes.040.s1.238.

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INTRODUCTIONChildhood obesity (CO) clinic has served as screening and intervention center. Weight management programs in children have not been fully established. This report is to understand the outcome after 2 years of follow-up in the same clinic. METHODOLOGYChildren who were newly referred to the clinic from 2020–2023 (4 years) were identified. Patient demographic and anthropometric (weight, height, BMI, blood pressure and waist circumference) data at point 0 (first visit) and point 1 (2 years from the first clinic visit) were collected. RESULTA total of 78 new patients were included. Majo
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Lee, Choong-kun, Dong Hyun Seo, Daniel Aaron Fox, et al. "Impact of HER2-positivity on prognosis and targeted therapeutic outcomes in advanced biliary tract cancer." Journal of Clinical Oncology 43, no. 4_suppl (2025): 629. https://doi.org/10.1200/jco.2025.43.4_suppl.629.

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629 Background: HER2 overexpression and amplification have been identified as a promising druggable target in biliary tract cancer (BTC). This study aims to characterize the clinical and molecular outcomes associated with HER2 positivity in BTC and evaluate the prognostic implications of HER2-targeted therapies. Methods: A retrospective study was conducted involving patients with advanced BTC diagnosed at Yonsei Cancer Center (YCC) and the University of Texas MD Anderson Cancer Center (MDACC) between 2009 and 2023. Patients were classified as HER2-positive either by immunohistochemistry (IHC 3
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Ivanoff, Sarah, Emilie Lemasle, Berengere Gruson, et al. "Azacitidine in Relapsed and Refractory AML: Efficacy for Patients Relapsing As MDS Post AML." Blood 120, no. 21 (2012): 4332. http://dx.doi.org/10.1182/blood.v120.21.4332.4332.

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Abstract Abstract 4332 Background: Azacitidine (Aza), inhibitor of DNA methyltransferases, plays an important role in epigenetic regulation of gene expression and tumorogenesis, and is active in myeloid neoplasia such as myelodysplasia (MDS) and de novo acute myeloid leukemia (AML). Efficacy of Aza for relapsed and refractory AML has not been so far reported. Methods: We report in 2 french centers (Amiens, Rouen) retrospective study, the results of Aza for relapsed or refractory patients. All patients received Aza (75 mg/m2 per day over 7 days for 4 weeks cycles), until progression, and at lea
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Leone, J. P., V. Guardiola, A. Venkatraman, et al. "Neoadjuvant platinum-based chemotherapy (CT) for triple-negative locally advanced breast cancer (LABC): Retrospective analysis of 125 patients." Journal of Clinical Oncology 27, no. 15_suppl (2009): 625. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.625.

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625 Background: Triple-negative breast cancer (TNBC), defined by lack of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, accounts for 15–20% of all breast cancers and is associated with poor prognosis. There is no consensus regarding optimal CT for treatment of such patients. Preclinical data suggests TNBC may be sensitive to platinums because of deficiencies in BRCA-associated DNA repair. The aim of this study was to evaluate pathologic complete response (pCR) and overall survival (OS) in patients with TNBC treated with neoadjuvant platinum-based CT. Me
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Devarajulu, Kavitha, and Prabu Velusamy. "A study of etiology, clinical profile and outcome in children aged 1-12 years presenting with fever of 1-3 weeks duration in a tertiary hospital." International Journal of Contemporary Pediatrics 6, no. 2 (2019): 569. http://dx.doi.org/10.18203/2349-3291.ijcp20190073.

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Background: The objective of the study was to find out the etiology, associated signs and symptoms of fever of 1-3 weeks in the age group of 1-12 years and their outcome following treatment in a tertiary care hospital.Methods: This was an observational prospective study conducted at Institute of child health and hospital for children, Egmore, Chennai during the period from January 2011 to October 2012. A total of 621 children aged 1-12 years with 1-3 weeks of fever were included in the study. Demographic, clinical and diagnostic data were collected and analyzed for each patient and outcome was
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Chablani, Priyanka, Theodore Karrison, and Walter Stadler. "629 Evaluation of provider preferences in first-line metastatic renal cell carcinoma: comparison between dual immunotherapy vs. immunotherapy/tyrosine kinase inhibitors." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A659. http://dx.doi.org/10.1136/jitc-2021-sitc2021.629.

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BackgroundDual immunotherapy (ipilimumab/nivolumab, IO/IO) and immunotherapy/tyrosine kinase inhibitor (IO/TKI) combinations (e.g. pembrolizumab/axitinib) are approved for first-line therapy of intermediate/poor risk metastatic renal cell carcinoma (RCC),1–4 but there is limited comparative data between these two options. We sought to understand how physicians decide between IO/IO vs. IO/TKI for this indication.MethodsWe sent a 10-question survey focused on a patient scenario of intermediate/poor risk metastatic RCC to 294 general and academic/disease-focused oncologists throughout the country
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Francissen, C. M. T. P., R. F. D. van la Parra, A. H. Mulder, A. M. Bosch, and W. K. de Roos. "Evaluation of the Benefit of Routine Intraoperative Frozen Section Analysis of Sentinel Lymph Nodes in Breast Cancer." ISRN Oncology 2013 (September 16, 2013): 1–5. http://dx.doi.org/10.1155/2013/843793.

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Aims. Intraoperative analysis of the sentinel lymph node (SLN) by frozen section (FS) allows for immediate axillary lymph node dissection (ALND) in case of metastatic disease in patients with breast cancer. The aim of this study is to evaluate the benefit of intraoperative FS, with regard to false negative rate (FNR) and influence on operation time. Materials and Methods. Intraoperative analysis of the SLN by FS was performed on 628 patients between January 2005 and October 2009. Patients were retrospectively studied. Results. FS accurately predicted axillary status in 525 patients (83.6%). Th
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Aydin, Serap, Nafiz Arica, Emrah Ergul, and Oğuz Tan. "Classification of Obsessive Compulsive Disorder by EEG Complexity and Hemispheric Dependency Measurements." International Journal of Neural Systems 25, no. 03 (2015): 1550010. http://dx.doi.org/10.1142/s0129065715500100.

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In the present study, both single channel electroencephalography (EEG) complexity and two channel interhemispheric dependency measurements have newly been examined for classification of patients with obsessive–compulsive disorder (OCD) and controls by using support vector machine classifiers. Three embedding entropy measurements (approximate entropy, sample entropy, permutation entropy (PermEn)) are used to estimate single channel EEG complexity for 19-channel eyes closed cortical measurements. Mean coherence and mutual information are examined to measure the level of interhemispheric dependen
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He, Xin, Kyriakie Sarafoglou, Patricia Y. Fechner, et al. "Changes in Adrenal and Gonadal Androgens After 14-Day Treatment With CRF1 Receptor Antagonist, Crinecerfont (NBI-74788), in Men With Classic 21-Hydroxylase Deficiency." Journal of the Endocrine Society 5, Supplement_1 (2021): A78. http://dx.doi.org/10.1210/jendso/bvab048.157.

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Abstract Background: Congenital adrenal hyperplasia due to classic 21-hydroxylase deficiency (21OHD) causes cortisol insufficiency and androgen excess. A phase 2 trial of crinecerfont, a CRF1 receptor antagonist, in 18 adults with 21OHD showed prominent decreases in ACTH, 17-hydroxyprogesterone, and androstenedione (A4), and in women, testosterone (T), after 14 days of treatment. In men with 21OHD, T derives from both adrenals and testes; in poor disease control, A4/T ratio is elevated due to disproportionately increased adrenal A4 production and decreased testicular T production. We sought to
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Vieira Bento Silva, A. D., M. H. Fernandes Lourenco, S. Ramiro, et al. "POS0678 PERFORMANCE OF CLINICAL, LABORATORY AND IMAGING FEATURES FOR THE DIAGNOSIS OF AXIAL SPONDYLOARTHRITIS - A SYSTEMATIC LITERATURE REVIEW AND META-ANALYSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 621.1–621. http://dx.doi.org/10.1136/annrheumdis-2023-eular.108.

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BackgroundThe Berlin algorithm for axial spondyloarthritis (axSpA) diagnosis was developed more than 15 years ago. New evidence suggests that the diagnostic performance of some SpA features might not be as good as initially thought.ObjectivesTo review the evidence on the performance of SpA features for axSpA diagnosis.MethodsSystematic literature review and meta-analysis of studies (2004-2021) reporting data on ≥1 SpA feature. The population was defined as adults (≥16 years) with a suspicion or definite clinical diagnosis of axSpA. The diagnostic performance of each SpA feature was tested agai
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Saffarzadeh, Mona, Chad E. Eckert, Deborah Nagle, et al. "Pelvic and Lower Gastrointestinal Tract Anatomical Characterization of the Average Male." Surgical Innovation 26, no. 2 (2018): 180–91. http://dx.doi.org/10.1177/1553350618812317.

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Objective. Colorectal surgeons report difficulty in positioning surgical devices in males, particularly those with a narrower pelvis. The objectives of this study were to (1) characterize the anatomy of the pelvis and surrounding soft tissue from magnetic resonance and computed tomography scans from 10 average males (175 cm, 78 kg) and (2) develop a model representing the mean configuration to assess variability. Methods. The anatomy was characterized from existing scans using segmentation and registration techniques. Size and shape variation in the pelvis and soft tissue morphology was charac
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Caruso, Paola, Maria Ida Maiorino, Miriam Longo, et al. "Liraglutide for Lower Limb Perfusion in People With Type 2 Diabetes and Peripheral Artery Disease." JAMA Network Open 7, no. 3 (2024): e241545. http://dx.doi.org/10.1001/jamanetworkopen.2024.1545.

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ImportancePeripheral artery disease (PAD) in diabetes may lead to diabetic foot ulcer and lower-extremities amputation. Glucagon-like peptide 1 receptor agonists have proven cardiovascular benefits in trials of people with type 2 diabetes at high cardiovascular risk.ObjectiveTo examine the effect of liraglutide on peripheral perfusion measured as peripheral transcutaneous oxygen pressure (TcPo2) in individuals with type 2 diabetes and PAD.Design, Setting, and ParticipantsThis open-label randomized clinical trial was conducted between February 1, 2021, and June 30, 2022, with a final follow-up
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Blomme, Guy, Petronille Dusingizimana, Jules Ntamwira, et al. "Comparing effectiveness, cost- and time-efficiency of control options for Xanthomonas wilt of banana under Rwandan agro-ecological conditions." European Journal of Plant Pathology 160, no. 2 (2021): 487–501. http://dx.doi.org/10.1007/s10658-021-02258-z.

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AbstractXanthomonas wilt of banana (XW) is a major disease affecting banana throughout East and Central Africa (ECA). Initial control was through complete diseased mat uprooting (CDMU), which had limited adoption due to high labour demands and cost. Further research demonstrated single diseased stem removal (SDSR) was an effective, less labour intensive and less costly alternative to CDMU. A comparative assessment of the two control practices was needed to foster uptake by policy makers, especially in countries like Rwanda where SDSR had not been tested or scaled up. To test SDSR in Rwanda, a
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Schäufele, Martina, Siegfried Weyerer, Ingrid Hendlmeier, and Leonore Köhler. "Alkoholbezogene Störungen bei Menschen in Einrichtungen der stationären Altenhilfe: eine bundesweite repräsentative Studie." SUCHT 55, no. 5 (2009): 292–302. http://dx.doi.org/10.1024/2009.05.04.

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Fragestellung: Ziel der Studie war es, erstmals in Deutschland auf der Grundlage einer bundesweiten repräsentativen Stichprobe die Prävalenz alkoholbezogener Störungen und damit assoziierte Charakteristika in der Bewohnerschaft von Altenpflegeheimen zu ermitteln. </p><p> Methodik: Ausgehend von einer für Deutschland repräsentativen Zufallsstichprobe von 609 vollstationären Pflegeeinrichtungen (Erhebung durch TNS Infratest Sozialforschung), wurde durch ein zweistufiges geschichtetes Zufallsverfahren eine Substichprobe (Stufe 1: N=185 Heime; Stufe 2: N=86 Heime) für die vorliegende U
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Zhao, Ke, Ren Lin, Zhiping Fan, et al. "Mesenchymal Stromal Cells Plus Anti-CD25 Antibody and Calcineurin Inhibitors for Steroid-Resistant Acute Graft-Versus-Host Disease: A Multicenter, Randomized, Phase 3 Trial." Blood 138, Supplement 1 (2021): 260. http://dx.doi.org/10.1182/blood-2021-146739.

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Abstract INTRODUCTION Steroid-resistant (SR) acute graft-versus-host disease (aGVHD) lacks standard second-line treatment. Mesenchymal stromal cells (MSCs) have potential efficacy in SR aGVHD. To assess efficacy and safety of MSCs combined with anti-CD25 antibody and calcineurin inhibitors as second-line therapy for SR aGVHD. METHORDS A randomized phase 3 trial involved 203 SR aGVHD patients at 10 centers in China (September 2014-March 2019). Final follow-up was on June 30, 2020. Participants were randomized in a 1:1 ratio to receive second-line therapy (anti-CD25 antibody combined with calcin
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Walz, Lars, Gian M. Salzmann, Thomas Fabbro, Stefan Eichhorn, and Andreas B. Imhoff. "The Anatomic Reconstruction of Acromioclavicular Joint Dislocations Using 2 TightRope Devices." American Journal of Sports Medicine 36, no. 12 (2008): 2398–406. http://dx.doi.org/10.1177/0363546508322524.

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Background For the reconstruction of acromioclavicular (AC) joint separation, several operative procedures have been described; however, the anatomic reconstruction of both coracoclavicular ligaments has rarely been reported. Purpose The aim of this biomechanical study is to describe a new procedure for anatomic reconstruction of the AC joint. Study Design Controlled laboratory study. Materials and Methods Forty fresh-frozen cadaveric shoulders were tested. Cyclic loading and a load-to-failure protocol was performed in vertical (native, n = 10; reconstructed, n = 10) and anterior directions (n
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Moriya, Toshiyuki, Tomohisa Hikota, Isao Yumoto, et al. "Calditerricola satsumensis gen. nov., sp. nov. and Calditerricola yamamurae sp. nov., extreme thermophiles isolated from a high-temperature compost." International Journal of Systematic and Evolutionary Microbiology 61, no. 3 (2011): 631–36. http://dx.doi.org/10.1099/ijs.0.018416-0.

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Two novel thermophilic micro-organisms, designated YMO81T and YMO722T, were isolated from a high-temperature compost (internal temperature >95 °C). The isolates were able to grow at 80 °C in a nutrient broth and in a synthetic medium. Cells were aerobic, Gram-negative rods (0.3×4.0 μm). Spore formation was not observed. Strain YMO81T grew at 83 °C and pH 6.9–8.9 and grew optimally at 78 °C and pH 7.5 with 2 % NaCl. For growth in a synthetic minimal medium at 70 °C, the vitamins biotin, folic acid and thiamine and the amino acids glutamine and methionine were essential for growth of both str
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Herbert, Annie, Gary A. Abel, Sam Winters, Sean McPhail, Lucy Elliss-Brookes, and Georgios Lyratzopoulos. "Cancer diagnoses after emergency GP referral or A&E attendance in England: determinants and time trends in Routes to Diagnosis data, 2006–2015." British Journal of General Practice 69, no. 687 (2019): e724-e730. http://dx.doi.org/10.3399/bjgp19x705473.

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BackgroundDiagnosis of cancer as an emergency is associated with poor outcomes but has a complex aetiology. Examining determinants and time trends in diagnostic routes can help to appreciate the critical role of general practice over time in diagnostic pathways for patients with cancer.AimTo examine sociodemographic, cancer site, and temporal associations with type of presentation among patients with cancer diagnosed as emergencies.Design and settingAnalysis of Routes to Diagnosis data, 2006–2015, for patients with cancer in England.MethodThe authors estimated adjusted proportions of emergency
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Harefa, Misael Oktavianda, and Soeb Aripin. "Penerapan Metode K-Means Dalam Pengelompokkan Buku Untuk Menentukan Minat Baca Pada Perpustakaan Daerah Kota Medan." Bulletin of Artificial Intelligence 3, no. 1 (2024): 26–34. http://dx.doi.org/10.62866/buai.v3i1.129.

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The library is a facility that functions as an information center, a source of various knowledge, research, recreation and cultural preservation. The Medan City Regional Library is a library organized by the regional government using general funds which aims to serve the public in obtaining comprehensive information without distinguishing gender, religion, race, age, occupation and position. In 2021 the Medan city regional library has 28 thousands of titles books in several categories. Of the many books contained in the library, a system must be needed where the system is useful for both the l
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32

El-Shamy, Hasan M. "Twins/Zwillinge: A Broader View. A Contribution to Stith Thompson’s Incomplete Motif System—A Case of the Continuation of Pseudoscientific Fallacies †." Humanities 10, no. 1 (2020): 8. http://dx.doi.org/10.3390/h10010008.

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Explaining the rationale and main objectives for his motif system; Stith Thompson declared that it emulates what “the scientists have done with the worldwide phenomena of biology” (Thompson 1955, I, p. 10). In this respect; the underlying principles for motif identification and indexing are comparable to those devised by anthropologists at Yale for “categorizing” culture materials into 78 macro-units and 629 subdivisions thereof used to establish “The Human Relations Area Files” (HRAF). By comparison, 23 divisions (chapters) make up the spectrum of sociocultural materials covered in Thompson’s
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Guida, José, Fernanda Surita, Mary Parpinelli, and Maria Costa. "Preterm Preeclampsia and Timing of Delivery: A Systematic Literature Review." Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics 39, no. 11 (2017): 622–31. http://dx.doi.org/10.1055/s-0037-1604103.

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Introduction Preeclampsia, a multifactorial disease with pathophysiology not yet fully understood, is a major cause of maternal and perinatal morbidity and mortality, especially when preterm. The diagnosis is performed when there is an association between arterial hypertension and proteinuria or evidence of severity. There are unanswered questions in the literature considering the timing of delivery once preterm preeclampsia has been diagnosed, given the risk of developing maternal complications versus the risk of adverse perinatal outcomes associated with prematurity. The objective of this sy
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Ferro, M. M., L. O. Tedeschi, and A. S. Atzori. "The comparison of the lactation and milk yield and composition of selected breeds of sheep and goats." Translational Animal Science 1, no. 4 (2017): 498–506. http://dx.doi.org/10.2527/tas2017.0056.

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Abstract The objective of this study was to characterize the milk yield (MY) and milk composition of relevant sheep and goat breeds raised around the world to be used with nutrition models for diet formulation and nutrient balancing. A 2-step approach was used. First, a database developed by the Food and Agriculture Organization was used to identify relevant breeds (i.e., frequently raised) by comparing the occurrence of transboundary breed names across countries. We selected transboundary breeds that occurred more than 3 times and other relevant breeds obtained from the specialized literature
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35

Burekovic, Azra, and Anida Divanovic. "Is It the COVID-19 and Untreated Panhypopituitarism a Deadly Combination: A Case Report?" Journal of the Endocrine Society 5, Supplement_1 (2021): A590. http://dx.doi.org/10.1210/jendso/bvab048.1203.

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Abstract Background: The possible long-term consequences of coronavirus disease (COVID-19) on the endocrine system are still not known. With the number of cases rising we have reported the first possible implications of COVID-19 on panhypopituitarism in Bosnia and Herzegovina. Clinical Case: A 59-year-old man was referred to the Endocrinology Counseling Center on 12/10/2020. For 15 years he did not take thyroid and adrenal replacement therapy. As a child, he was treated for short stature, as well as his two sisters. He had signs and symptoms of myxedema. He was urgently hospitalized to the Dep
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Dowling, Brittany, Derrick M. Knapik, Micheal J. Luera, Grant E. Garrigues, Gregory P. Nicholson, and Nikhil N. Verma. "Influence of Pelvic Rotation on Lower Extremity Kinematics, Elbow Varus Torque, and Ball Velocity in Professional Baseball Pitchers." Orthopaedic Journal of Sports Medicine 10, no. 11 (2022): 232596712211303. http://dx.doi.org/10.1177/23259671221130340.

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Background: Early pelvic rotation has been associated with decreased throwing arm kinetics in college baseball pitchers, though professional pitchers have yet to be examined. Purpose: To investigate the effect of pelvic rotation on trunk, pelvis and lower extremity kinematics, as well as throwing arm kinetics and pitch velocity in professional baseball pitchers. Study Design: Descriptive laboratory study. Methods: Data were analyzed for 157 professional baseball pitchers throwing fastballs using 3-dimensional motion capture (480 Hz). Pitchers were divided into an open pelvis (rotated toward ta
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Monahan, Rory C., Liesbeth JJ Beaart-van de Voorde, Jeroen Eikenboom, et al. "Fatigue in patients with systemic lupus erythematosus and neuropsychiatric symptoms is associated with anxiety and depression rather than inflammatory disease activity." Lupus 30, no. 7 (2021): 1124–32. http://dx.doi.org/10.1177/09612033211005014.

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Introduction We aimed to investigate risk factors for fatigue in patients with systemic lupus erythematosus (SLE) and neuropsychiatric symptoms in order to identify potential interventional strategies. Methods Patients visiting the neuropsychiatric SLE (NPSLE) clinic of the Leiden University Medical Center between 2007–2019 were included. In a multidisciplinary consensus meeting, SLE patients were classified as having neuropsychiatric symptoms of inflammatory origin (inflammatory phenotype) or other origin (non-inflammatory phenotype). Fatigue was assessed with the SF-36 vitality domain (VT) s
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Nakabayashi, M., O. Sartor, S. Jacobus, et al. "Response to docetaxel (D)/carboplatin (C)-based chemotherapy as first- and second-line therapy in patients with metastatic hormone-refractory prostate cancer (HRPC)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 5156. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.5156.

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5156 Background: Effective treatment options for HRPC patients are limited. We evaluated efficacy of D/C-based chemotherapy as first- and second-line chemotherapy. Methods: We retrospectively identified all patients with HRPC treated with D/C-based chemotherapy at DFCI. Regimens either included estramustine (EDC) or not (DC). Patients treated with EDC received D 20–70 mg/m2 q1–4 weeks, E 140mg TID and C AUC 4–6 q 3–4 weeks. Patients treated with DC received D 50–70 mg/m2 and C AUC 4–5 q 3–4 weeks. PSA declines and measurable response were assessed per PSA Working Group and RECIST criteria, res
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Schiller, Gary J., Daniel J. DeAngelo, Arnaud Pigneux, et al. "Phase II Study of VNP40101M (Cloretazine®) in Elderly Patients with De Novo Poor Risk Acute Myelogenous Leukemia (AML)." Blood 110, no. 11 (2007): 917. http://dx.doi.org/10.1182/blood.v110.11.917.917.

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Abstract VNP40101M (Cloretazine®) is a novel sulfonylhydrazine alkylating agent which preferentially targets the O6 position of guanine resulting in DNA cross-links. Data from a previously reported phase II multi-center single agent study (CLI-033) in patients ≥60 years old with newly diagnosed AML or high risk MDS showed an overall response rate of 31% after VNP40101M induction (Giles, 2007). Subgroup analysis showed significant activity in 54 elderly patients with de novo AML with 24 patients (45%) achieving a complete response (CR) or CRp (CI: 30.9;58.6). Subsequently a confirmatory phase I
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40

Kuznetsov, V. K., A. V. Panov, N. I. Sanzharova, et al. "The analysis of radioecological monitoring results in the vicinity of the Kursk Nuclear Power Plant." Radiatsionnaya Gygiena = Radiation Hygiene 13, no. 2 (2020): 19–30. http://dx.doi.org/10.21514/1998-426x-2020-13-2-19-30.

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The research presents the data of long-term observations of the impact of the Kursk Nuclear Power Plant operation on the radioecological situation in the region of its location. The dynamics of the content of natural and artificial radionuclides in the components of agricultural ecosystems was studied due to the data based on the information from the radioecological monitoring network developed in 2003. Samples of soils, agricultural products and animal feeds were taken at 11 control sites located on arable lands and grasslands in the vicinity of the Kursk Nuclear Power Plant, and, in settleme
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JE, Shitaye, I. Parmova, L. Matlova, et al. "Mycobacterial and Rhodococcus equiinfections in pigs in theCzechRepublicbetween the years 1996 and 2004: the causal factors and distribution of infections in the tissues." Veterinární Medicína 51, No. 11 (2012): 497–511. http://dx.doi.org/10.17221/5584-vetmed.

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Between 1996 and 2004, tissue samples from 3 630 slaughtered pigs were examined by gross examination, microscopy after the Ziehl-Neelsen (ZN) staining of homogenised tissues for the detection of acid-fast rods (AFR) and by culture for the presence of mycobacteria and Rhodococcus equi: 1 781 head lymph nodes (ln), 1 123 mesenteric ln, 54 pulmonary ln, 32 inguinal ln, 562 non-identified ln and 78 samples of tissues from parenchymatous organs (liver, spleen and kidneys). Tuberculous/tuberculoid lesions were not detected in 249 (6.9%) animals slaughtered due to
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42

Rivera Teran, V., D. Alpizar-Rodriguez, S. Sicsik, et al. "FRI0546 GENDER DIFFERENCES OF RHEUMATIC DISEASES IN MEXICAN POPULATION: DATA FROM THE MEXICAN BIOLOGICS REGISTRY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 874–75. http://dx.doi.org/10.1136/annrheumdis-2020-eular.6091.

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Background:Most autoimmune diseases are more prevalent in women. Symptom severity, disease progression, response to therapy and overall survival differ between males and females with rheumatic diseases.Objectives:To identify the characteristics of autoimmune diseases presentation and treatment between male and female population using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican ongoing cohort that collects the information of patients using biologic and biosimilar drugs since 2016. For this study we included all patients enrolled in the regis
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Pulia, Michael S., Meggie Griffin, Rebecca Schwei, et al. "Antibiotic Treatment in Patients Hospitalized for Nonsevere COVID-19." JAMA Network Open 8, no. 5 (2025): e2511499. https://doi.org/10.1001/jamanetworkopen.2025.11499.

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ImportancePatients hospitalized with nonsevere COVID-19 continue to receive community-acquired pneumonia (CAP) antibiotic treatment despite a low risk of bacterial coinfection. Unnecessary antibiotic prescribing contributes to global antibiotic resistance and also poses a threat to individual patients.ObjectiveTo examine the association of CAP antibiotic treatment started on admission with clinical outcomes among a large sample of patients hospitalized for nonsevere COVID-19 in hospitals across the US.Design, Setting, and ParticipantsThis retrospective cohort study used a target trial emulatio
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Ricciuto, A., H. McKay, J. deBruyn, et al. "P512 Early proactive therapeutic drug monitoring with ustekinumab therapy in paediatric Crohn's Disease." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i1012—i1013. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0642.

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Abstract Background In the treatment of paediatric Crohn’s disease (CD), the youngest (lightest) children have historically been underdosed by standard weight-based dosing. Paediatric data on optimal dosing and drug levels are sparse. We aimed to examine real-world post-induction pharmacokinetic and effectiveness in a prospective multicentre paediatric CD cohort. Methods Luminal CD patients 2-17 years old in the Canadian Children IBD Network were eligible if they received UST IV and had a serum UST level measured proactively at week (wk) 8. Wk8 and subsequent UST levels were compared between c
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Leitch, Heather A., Dominic H. C. Wong, Chantal S. Leger, et al. "Improved Leukemia-Free and Overall Survival in Patients with Myelodysplastic Syndrome Receiving Iron Chelation Therapy: A Subgroup Analysis." Blood 110, no. 11 (2007): 1469. http://dx.doi.org/10.1182/blood.v110.11.1469.1469.

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Abstract Myelodysplastic syndrome (MDS) is characterized by ineffective hematopoiesis and risk of progression to acute myeloid leukemia (AML). Many MDS patients (pts) require red blood cell (RBC) transfusions, risking iron overload (IOL)-related organ dysfunction. We previously showed in a multivariate analysis of 178 pts, improved survival in 18 pts with low and int-1 IPSS risk MDS and IOL receiving iron chelation therapy (ICT), and now examine the effect of ICT on AML-free survival (LFS). The effect of ICT on cytopenias and RBC transfusion requirements (TR); was also examined. To control for
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46

Farinha, Pedro, Christian Steidl, Lisa M. Rimsza, Kerry J. Savage, Joseph M. Connors, and Randy D. Gascoyne. "HLA-DR Protein Expression Correlates with Non-Neoplastic T-Cell Infiltration and Predicts Survival in Patients with Primary Mediastinal Large B Cell Lymphoma (PMBCL) Treated with CHOP Chemotherapy." Blood 114, no. 22 (2009): 133. http://dx.doi.org/10.1182/blood.v114.22.133.133.

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Abstract 133 Background: PMBCL represents a unique lymphoma type in the WHO classification and shares overlapping histological and gene expression features with both diffuse large B-cell (DLBCL) and classical Hodgkin lymphoma. Similar to DLBCL, PMBCL may show loss of expression of the major histocompatibility class II (MHC II) antigens, which correlates with inferior patient survival (Rimsza, Blood 2006). MHC II proteins are expressed on antigen-presenting cells and are important in eliciting immune responses. In DLBCL, decreased expression of HLA-DR is related to loss of immunosurveillence. O
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Mercado, Marta Ruiz, Estrella Carrillo Cruz, Fátima de la Cruz Vicente, et al. "The Role Of 18F-FDG PET/CT For Staging and Response Assessment To Chemotherapy In Marginal Zone Lymphoma." Blood 122, no. 21 (2013): 4328. http://dx.doi.org/10.1182/blood.v122.21.4328.4328.

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Abstract Introduction Marginal Zone Lymphoma (MZL) is an indolent lymphoma in which the use of PET/CT is poorly explored and also controversial due to the heterogeneous 18F- FDG avidity described in these types of lymphoma. Our aim in the present study is to evaluate the role of 18F-FDG-PET/ CT (PET/CT) in comparison to CT with intravenous contrast enhancement at initial staging and response assessment to chemotherapy in these patients. Methods and Materials A retrospective single-center study that included 34 patients, diagnosed of MZL between 1998 and 2012, with at least one PET/CT available
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Obeid, Sahar, Vanessa Azzi, and Souheil Hallit. "Validation and psychometric properties of the Arabic version of Hamilton Depression Rating Scale 7 items (HAMD-7) among non-clinical and clinical samples of Lebanese adults." PLOS ONE 18, no. 5 (2023): e0285665. http://dx.doi.org/10.1371/journal.pone.0285665.

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Background The Hamilton Depression Rating Scale (HDRS or HAMD) is widely used scale for depression assessment. A shortened version of the HDRS, composed of 7 items, was implemented. The latter is timesaving compared to the original version, while still providing similar precision. Our objective in this study was to assess the psychometric properties of the Arabic HAMD-7 scale among non-clinical and clinical samples of Lebanese adults. Methods In study 1, 443 Lebanese citizens enrolled in this cross-sectional study (June-September 2021). The total sample in study 1 was divided into two subsampl
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Begna, Kebede H., Naseema Gangat, Mithun V. Shah, et al. "Anthracycline Choices for Induction Chemotherapy Among 797 Consecutive Adult Patients with Acute Myeloid Leukemia: Daunorubicin-60 Vs Idarubicin-12 Vs Daunorubicin-90." Blood 138, Supplement 1 (2021): 1267. http://dx.doi.org/10.1182/blood-2021-147485.

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Abstract Objective : We describe the Mayo Clinic experience in 797 newly-diagnosed patients with acute myeloid leukemia (AML) serially treated with 7+3 induction chemotherapy that included 3 days of daunorubicin at a daily dose of 60 mg/m2 (dauno-60; n=239) or 90 mg/m2 (dauno-90; n=52), or idarubicin 12 mg/m2 (IDA-12; n=506). Our objective was to compare overall (OS) and relapse-free (RFS) survival outcome. Methods : Newly-diagnosed AML patients seen at our institution and received intensive induction chemotherapy were identified from the Mayo Clinic AML database. Treatment period spanned from
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Martín Moro, Fernando, Ana Jiménez Ubieto, Marina Gomez Llobell, et al. "A New Prognostic Index Including Baseline Clinico-Biological Variables Predicts Outcome in Plasmablastic Neoplasms." Blood 144, Supplement 1 (2024): 4478. https://doi.org/10.1182/blood-2024-212008.

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Background: Plasmablastic neoplasms are rare and aggressive tumors that exhibit biological complexity and poor prognosis despite intensive approaches. Our aims were to evaluate the prognostic impact of clinical and biological variables in a series of plasmablastic neoplasms and to design a prognostic score. Besides, we analyzed the first-line therapeutic approach. Methods: Multicentric retrospective study within the Spanish Lymphoma Group (GELTAMO) including de novo plasmablastic neoplasms. Clinical, biological and therapeutic variables were analyzed, highlighting the evaluation of 17 markers
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