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Journal articles on the topic '629.802 89'

Author: Grafiati

Published: 29 March 2025

Last updated: 31 July 2025

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1

Beringer, Richard E. "Media Review." Teaching History: A Journal of Methods 13, no. 2 (1988): 76–79. http://dx.doi.org/10.33043/th.13.2.76-79.

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Leaders of the 20th Century. 26 videocassettes, each 24 minutes. Film study guides for each film and a companion volume. Available in 1/2" VHS, 1/2" Beta I or II, and 3/4" U-Matic. Order from Learning Corporation of America, 108 Wilmot Road, Deerfield, IL 60015. 1-800-621-2121. $89 per unit ($79 per unit if order ten or more). Review by Richard E. Beringer of the University of North Dakota.

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Ozturk, Fahrettin, Serkan Toros, Suleyman Kilic, and Ilyas Kacar. "Evaluation of Anisotropy by Two Different Tests for TRIP800 Steel." Key Engineering Materials 622-623 (September 2014): 1139–44. http://dx.doi.org/10.4028/www.scientific.net/kem.622-623.1139.

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For the process modeling, material properties such as anisotropy values at different orientation are very important. The most commonly used method for the determining of the anisotropy values is the tensile test that is performed for samples are prepared at different orientation. Besides the tensile test, the anisotropy parameters of TRIP 800 steel are measured with the hole-expansion test. The effects of the test methods on the yield surfaces are determined for using two different anisotropic yield criteria are Hill-48 and Barlat-89. Results illustrated that a significant difference is observ

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Rueang-amnat, Nawinda, Kulnipa Kittisakmontri, Varangthip Khuwuthyakorn, Shanika Kosarat, Satit Manopunya, and Mallika Pomrop. "Improving Vitamin D Status in Preterm Newborns: A Randomized Trial of 800 vs. 400 IU/Day." Nutrients 17, no. 11 (2025): 1888. https://doi.org/10.3390/nu17111888.

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Background and Aims: Preterm newborns are particularly susceptible to hypovitaminosis D, potentially impairing bone mineralization. In Thailand, data on its prevalence and standardized supplementation protocols remain limited. This study aimed to compare the efficacy of two vitamin D3 dosages (400 IU/day vs. 800 IU/day) in improving serum vitamin D concentrations and metabolic bone parameters in preterm newborns. Methods: A randomized controlled trial was conducted in preterm newborns born at ≤32 weeks’ gestation or with birth weight ≤1500 g. Preterm newborns were randomized to receive either

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Jontof-Hutter, Daniel, Paul A. Dalba, and John H. Livingston. "TESS Observations of Kepler Systems with Transit Timing Variations." Astronomical Journal 164, no. 2 (2022): 42. http://dx.doi.org/10.3847/1538-3881/ac7396.

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Abstract We identify targets in the Kepler field that may be characterized by transit timing variations and are detectable by the Transiting Exoplanet Survey Satellite (TESS). Despite the reduced signal-to-noise ratio of TESS transits compared to Kepler, we recover 48 transits from 13 systems in Sectors 14, 15, 26, 40 and 41. We find strong evidence of a nontransiting perturber orbiting Kepler-396 (KOI-2672) and explore two possible cases of a third planet in that system that could explain the measured transit times. We update the ephemerides and mass constraints where possible at KOI-70 (Kepl

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Qin, Lu, Dongqi Wang, Zhe Zhang, et al. "Impact of Dissolved Oxygen on the Performance and Microbial Dynamics in Side-Stream Activated Sludge Hydrolysis Process." Water 15, no. 11 (2023): 1977. http://dx.doi.org/10.3390/w15111977.

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Dissolved oxygen (DO) plays an important role in the performance of biological wastewater treatment systems. This study investigated the effect of the DO concentration on nutrient removal performance and microbial community structure in side-stream activated sludge hydrolysis (SSH) and conventional anaerobic/anoxic/aerobic (A2O) processes. The results showed that the change in DO had little effect on the removal performance of chemical oxygen demand (COD), and the removal efficiencies were about 90% for both reactors. Compared with the high DO level (4.1–6.9 mg/L), the A2O and SSH reactors had

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Yu, Helena Alexandra, Camelia S. Sima, Ronglai Shen, et al. "Comparison of the characteristics and clinical course of 677 patients with metastatic lung cancers with mutations in KRAS codons 12 and 13." Journal of Clinical Oncology 31, no. 15_suppl (2013): 8025. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8025.

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8025 Background: Patients (pts) with KRAS mutant lung cancers have a shorter survival compared to pts with KRAS/EGFR wild type tumors (Johnson et al, Cancer 2012). Whether outcomes for patients with KRAS mutant metastatic lung cancers differ by smoking status or specific amino acid substitution is unknown. In order to understand the impact of KRAS mutation subtype in the metastatic setting, we analyzed a large cohort of patients with KRAS mutant metastatic lung cancer. Methods: We identified all pts with KRAS mutant metastatic or recurrent lung cancers from Feb 2005 to Aug 2011. KRAS mutation

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Arciero, P. J., A. W. Gardner, J. Calles-Escandon, N. L. Benowitz, and E. T. Poehlman. "Effects of caffeine ingestion on NE kinetics, fat oxidation, and energy expenditure in younger and older men." American Journal of Physiology-Endocrinology and Metabolism 268, no. 6 (1995): E1192—E1198. http://dx.doi.org/10.1152/ajpendo.1995.268.6.e1192.

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Age-related differences in energy expenditure, fat oxidation, and norepinephrine (NE) kinetics after caffeine ingestion were examined using a placebo-controlled double-blind study in 10 older (O, 65-80 yr) and 10 younger (Y, 19-26 yr) men who were moderate consumers of caffeine. Caffeine ingestion resulted in similar increases in Y and O men for plasma caffeine levels (Y = 89 +/- 100 to 6,340 +/- 1,938 ng/ml, P < 0.05; O = 124 +/- 38 to 7,066 +/- 2,366 ng/ml, P < 0.05) and energy expenditure (Y = 11%, 1.38 +/- 0.15 to 1.52 +/- 0.22 kcal/min, P < 0.05; O = 9.5%, 1.15 +/- 0.13 to 1.26 +

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Quoix, E. A., J. Oster, V. Westeel, et al. "Weekly paclitaxel combined with monthly carboplatin versus single-agent therapy in patients age 70 to 89: IFCT-0501 randomized phase III study in advanced non-small cell lung cancer (NSCLC)." Journal of Clinical Oncology 28, no. 18_suppl (2010): 2. http://dx.doi.org/10.1200/jco.2010.28.18_suppl.2.

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2 Background: Incidence of advanced NSCLC in the elderly is increasing. Specific trials for elderly are seldom and those patients are not optimally treated. Current recommendations are monotherapies with gemcitabine or vinorelbine. Methods: French multicentric randomized phase III study in pts aged 70 to 89, PS 0-2 with advanced NSCLC not irradiable, comparing a 3-weekly single agent therapy (gemcitabine 1,150 mg/m2 or vinorelbine 30 mg/m2, d1, d8: arm A) with carboplatin AUC 6 every 4 weeks + paclitaxel 90 mg/m2 (d1,8,15) doublet (arm B). Five cycles of single agent and 4 cycles of the double

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Rady, Mostafa M., Mohamed M. M. Salama, Sebnem Kuşvuran, et al. "Exploring the Role of Novel Biostimulators in Suppressing Oxidative Stress and Reinforcing the Antioxidant Defense Systems in Cucurbita pepo Plants Exposed to Cadmium and Lead Toxicity." Agronomy 13, no. 7 (2023): 1916. http://dx.doi.org/10.3390/agronomy13071916.

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The use of bio-stimulants (BSs) has become an important policy in managing many stressed crop plants through the regulation of the balance of phytohormones, osmo-protectors (OPs), antioxidant systems, and gene expression, all of which reflect plant growth and productivity. Garlic + onion extract (GOE) at a concentration of 2.0–3.0% and diluted bee honey solution (BHs) at a concentration of 1.0–1.5% were applied exogenously to squash (Cucurbita pepo) plants subjected to cadmium (Cd) + lead (Pb) stress (0.3 mM CdCl2 + 0.3 mM PbCl2). The objective was to determine the effects of these treatments

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Jones, Robert J., Syed A. Hussain, Andrew S. Protheroe, et al. "Randomized Phase II Study Investigating Pazopanib Versus Weekly Paclitaxel in Relapsed or Progressive Urothelial Cancer." Journal of Clinical Oncology 35, no. 16 (2017): 1770–77. http://dx.doi.org/10.1200/jco.2016.70.7828.

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Purpose Two previous single-arm trials have drawn conflicting conclusions regarding the activity of pazopanib in urothelial cancers after failure of platinum-based chemotherapy. Patients and Methods This randomized (1:1) open-label phase II trial compared the efficacy of pazopanib 800 mg orally with paclitaxel (80 mg/m2 days 1, 8, and 15 every 28 days) in the second-line setting. The primary end point was overall survival (OS). Results Between August 2012 and October 2014, 131 patients, out of 140 planned, were randomly assigned. The study was terminated early on the recommendation of the inde

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Pabst, Gabriel, Katharina Prochazka, Gudrun Pregartner, et al. "Impact of TP53 Mutated Subclones in Acute Myeloid Leukemia." Blood 132, Supplement 1 (2018): 1483. http://dx.doi.org/10.1182/blood-2018-99-110667.

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Abstract Introduction Acute myeloid leukemia (AML) with "TP53 mutation, chromosomal aneuploidy or both" has recently been described as a distinct AML subgroup exhibiting an exceedingly adverse prognosis. Therefore, testing for TP53 mutations has become an essential part of the European LeukemiaNet 2017 recommendations for risk classification. However, the incidence and pathogenic role of subclonal TP53 mutations defined by a variant allele frequency (VAF) <20% has not been addressed in this disorder yet. Methods We evaluated the prognostic value of TP53 VAFs in a cohort of 1537 patients wit

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Johnson, Sarah May, Jhia Jiat Teh, Thomas Joshua Pasvol, et al. "Hospitalisation rates for youth living with perinatally acquired HIV in England." PLOS ONE 19, no. 3 (2024): e0295639. http://dx.doi.org/10.1371/journal.pone.0295639.

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Introduction Complex challenges amongst ageing cohorts of adolescents and adults living with perinatally acquired HIV (PaHIV) may impact on hospitalisation. We report hospitalisation rates and explored predictive factors for hospitalisation in adolescents and adults (10–35 years) living with PaHIV in England. Method Retrospective observational cohort study over a three-year period 2016–2019. Data collected included cause and duration of hospitalisation, HIV viral load and CD4 lymphocyte count. The primary outcome was overnight hospitalisation. Patients exited at study end/ transfer of care (TO

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Lee, So-Ryoung, Chan Soon Park, Eue-Keun Choi, et al. "Hypertension Burden and the Risk of New-Onset Atrial Fibrillation." Hypertension 77, no. 3 (2021): 919–28. http://dx.doi.org/10.1161/hypertensionaha.120.16659.

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The association between the cumulative hypertension burden and the development of atrial fibrillation (AF) is unclear. We aimed to investigate the relationship between hypertension burden and the development of incident AF. Using the Korean National Health Insurance Service database, we identified 3 726 172 subjects who underwent 4 consecutive annual health checkups between 2009 and 2013, with no history of AF. During the median follow-up of 5.2 years, AF was newly diagnosed in 22 012 patients (0.59% of the total study population; 1.168 per 1000 person-years). Using the blood pressure (BP) val

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Djordjevic, Zorana, Slobodan Jankovic, Olgica Gajovic, Nela Djonovic, Nevena Folic, and Zoran Bukumiric. "Hospital infections in a neurological intensive care unit: incidence, causative agents and risk factors." Journal of Infection in Developing Countries 6, no. 11 (2012): 798–805. http://dx.doi.org/10.3855/jidc.2659.

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Introduction: Hospital infections (HIs), which are frequently associated with hospital treatment, increase morbidity, mortality and treatment costs. The aim of this study was to establish the incidence of HIs in a neurological intensive care unit (nICU), and to determine the most prevalent causative agents and risk factors for HIs. Methodology: A cross-sectional study with nested case-control design was conducted between 1 July 2009 and 30 June 2010 at an 18-bed neurological intensive care unit at the Clinical Center Kragujevac, Serbia. Results: In total, 537 patients were enrolled in the stud

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Abdollahpour, Soha, Azam Rahbar, Reza Mohammadhassan, Yasamin Talebi, and Yegane Bahrami Hesari. "An in silico Drug Repurposing Study to Inhibit the Spike Protein of SARS-CoV2." Momona Ethiopian Journal of Science 16, no. 2 (2024): 347–69. http://dx.doi.org/10.4314/mejs.v16i2.11.

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SARS-CoV2 has caused the recent mortal pandemic known as COVID-19. The drug repurposing approach can be employed to find the potential drugs capable of binding SARS-CoV2 structural and nonstructural proteins. The present study aimed to repurpose some common FAD-approved antiviral and non-antiviral drugs computationally for SARS-CoV2 treatment. In the in silico study, 89 FDA-approved drugs and Remdesivir, as the control, were analyzed by molecular docking to inhibit the SARS-CoV2 spike (S) protein as the key player in virus-cell binding. First, the Uniport website was used to find receptor and

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Hrbáček, Filip, Daniel Nývlt, Kamil Láska, et al. "Permafrost and active layer research on James Ross Island: An overview." Czech Polar Reports 9, no. 1 (2019): 20–36. http://dx.doi.org/10.5817/cpr2019-1-3.

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This study summarizes the current state of the active layer and permafrost research on James Ross Island. The analysis of climate parameters covers the reference period 2011–2017. The mean annual air temperature at the AWS-JGM site was -6.9°C (ranged from -3.9°C to -8.2°C). The mean annual ground temperature at the depth of 5 cm was -5.5°C (ranged from -3.3°C to -6.7°C) and it also reached -5.6°C (ranged from -4.0 to -6.8°C) at the depth of 50 cm. The mean daily ground temperature at the depth of 5 cm correlated moderately up to strongly with the air temperature depending on the season of the

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Sarawagi, Rashmi, Daya Nand Sharma, Rakesh Kumar, et al. "Positron emission tomography versus computed tomography -guided intracavitary brachytherapy for locally advanced cervical cancer: A prospective randomized study." Journal of Cancer Research and Therapeutics 21, no. 1 (2025): 151–55. https://doi.org/10.4103/jcrt.jcrt_1582_24.

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ABSTRACT Purpose: To compare early clinical outcomes in patients with locally advanced cervical cancer (LACC) treated with positron emission tomography–computed tomography (PET-CT) versus CT-guided intracavitary brachytherapy (ICBT) after external beam radiation therapy (EBRT). Materials and Methods: Patients with carcinoma cervix, stage IIB to IIIB, receiving EBRT with concurrent weekly cisplatin were randomized into two arms: PET-CT versus CT-guided ICBT arms. High-risk clinical target volume (HRCTV), rectum, bladder, and sigmoid colon were contoured. Planning, local control (LC), overall su

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Bhardwaj, S. C., M. Prashar, S. Kumar, S. K. Jain, and D. Datta. "Lr19 Resistance in Wheat Becomes Susceptible to Puccinia triticina in India." Plant Disease 89, no. 12 (2005): 1360. http://dx.doi.org/10.1094/pd-89-1360a.

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Lr19, a resistance gene originally transferred from Agropyron elongatum to wheat (Triticum aestivum L.), has remained effective worldwide against leaf rust (Puccinia triticina Eriks.) except in Mexico (1). This report records a new pathotype of P. triticina virulent on Lr19 from India. From 2003 to 2004, 622 wheat leaf rust samples from 14 states were subjected to pathotype analysis. Samples were established on susceptible wheat cv. Agra Local, and pathotypes were identified on three sets of differentials following binomial nomenclature (3). Virulence on Lr19 (Agatha T4 line) was observed in a

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Strangfeld, A., B. Manger, M. Worsch, T. Schmeiser, A. Zink, and M. Schaefer. "OP0116 ELDERLY PATIENTS ARE NOT AT INCREASED RISK OF SERIOUS INFECTIONS WHEN RECEIVING BDMARDS OR JAK INHIBITORS COMPARED TO CSDMARD TREATMENT." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 64.2–65. http://dx.doi.org/10.1136/annrheumdis-2021-eular.763.

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Background:Elderly rheumatoid arthritis (RA) patients are generally at increased risk of serious infections (SI). At the same time, treatment with bDMARDs has been associated with a higher SI risk than treatment with csDMARDs (1). However, long-term use of bDMARDs did not increase the risk of SI in a small group of elderly patients over 65 (2). The extent to which elderly patients are exposed to a higher SI risk when treated with JAK inhibitors (JAKi) is an open question.Objectives:To assess the effects of bDMARDs and specifically JAKi on the risk of SI in elderly patients with RA.Methods:The

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Descourt, Renaud, Laurent Greillier, Maurice Perol, et al. "First-line pembrolizumab monotherapy for PD-L1-positive (TPS ≥ 50%) advanced non-small cell lung cancer (aNSCLC) in the real world: A national French bispective multicentric cohort—ESCKEYP trial (GFPC 05-2018)." Journal of Clinical Oncology 39, no. 15_suppl (2021): 9091. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.9091.

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9091 Background: To determine real-world outcomes with first line pembrolizumab monotherapy, for aNSCLC with PD-L1 TPS ≥50%. Methods: Bispective, national and multicentric study including consecutively aNSCLC patients who initiated first-line pembrolizumab monotherapy from May 5, 2017 (marketing authorization of pembrolizumab monotherapy in France) to Nov 22, 2019 (marketing authorization of pembrolizumab-chemotherapy for non-squamous aNSCLC). Data were collected on medical charts. Responses were locally assessed according to RECIST v1.1; overall survival (OS) and real-world progression-free s

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Miller, James, Ryan Avery, Natalie Urie, Matthew Branan, and Joan M. Burke. "211 United States Department of Agriculture National Animal Health Monitoring System Goat 2019 study: Regional prevalence of gastrointestinal nematodes and lungworms in the United States." Journal of Animal Science 102, Supplement_3 (2024): 403–4. http://dx.doi.org/10.1093/jas/skae234.459.

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Abstract One objective of the United States Department of Agriculture National Animal Health Monitoring System Goat 2019 study (September 2019-April 2020) was to determine the prevalence of gastrointestinal nematode (GIN) and lungworm infection in goats across the US. Feces were collected from 5,176 animals on 318 operations in 24 states and results were consolidated into 4 regions: Northwest (3 states, 34 operations), Northeast (9 states, 89 operations), Southeast (9 states, 132 operations) and Southwest (3 states, 63 operations). Feces from each operation were mixed and cultured to allow egg

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Hlubocky, Fay J., David Cella, Tamara Sher, and Christopher K. Daugherty. "Impact of death anxiety (DA) on the psychological well-being and survival of patients with advanced cancer (ACP) in phase I trials and their spousal caregivers (SC)." Journal of Clinical Oncology 41, no. 16_suppl (2023): e24213-e24213. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e24213.

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e24213 Background: ACP and their SC experience psychological distress living with future uncertainty regarding their cancer. Yet, little is known how existential DA adversely impacts the psychological well-being and overall survival of ACP participating in Phase I trials and their SC. Methods: A prospective study of ACP enrolling in phase I trials and their SC were assessed at baseline (T1) and one month (T2) using quantitative symptom measures including: depression (CES-D), state anxiety (STAI-S), quality of life/qol (FACIT-Pal), and global health (SF-36). Semi-structured interviews evaluated

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Erina, A. M., O. P. Rotar, V. N. Solntsev, et al. "Epidemiology of Arterial Hypertension in Russian Federation – Importance of Choice of Criteria of Diagnosis." Kardiologiia 59, no. 6 (2019): 5–11. http://dx.doi.org/10.18087/cardio.2019.6.2595.

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Purpose. Assessment of prevalence of arterial hypertension (AH), need for prescription of antihypertensive therapy (AHT), and efficacy of AHT in Russian population in accordance with novel guideline of the American College of Cardiology/American Heart Association (“American recommendations”) on diagnosis and treatment of AH (2017).Materials and methods. Epidemiological study ESSE-RF (ЭССЕ-РФ) was carried out in 12 regions of Russian Federation (RF) with different climatic-geographic characteristics. Number of examined residents of RF aged 25–65 years was 20 652. The sample was stratified by ge

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Oliver, William M., Samuel G. Molyneux, Timothy O. White, Nick D. Clement, and Andrew D. Duckworth. "Return to work and sport after a humeral shaft fracture." Bone & Joint Open 3, no. 3 (2022): 236–44. http://dx.doi.org/10.1302/2633-1462.33.bjo-2021-0198.r1.

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Aims The primary aim of this study was to determine the rates of return to work (RTW) and sport (RTS) following a humeral shaft fracture. The secondary aim was to identify factors independently associated with failure to RTW or RTS. Methods From 2008 to 2017, all patients with a humeral diaphyseal fracture were retrospectively identified. Patient demographics and injury characteristics were recorded. Details of pre-injury employment, sporting participation, and levels of return post-injury were obtained via postal questionnaire. The University of California, Los Angeles (UCLA) Activity Scale w

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Jhaveri, K. L., G. Ulaner, M. Fazio, et al. "Standardized uptake value (SUV) by positron emission tomography/computed tomography (PET/CT) as a prognostic variable in metastatic breast cancer (MBC)." Journal of Clinical Oncology 29, no. 27_suppl (2011): 3. http://dx.doi.org/10.1200/jco.2011.29.27_suppl.3.

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3 Background: The accurate prediction of outcome from MBC could be useful if it could guide more effective therapies. Because PET/CT combines anatomical with functional imaging it could enable greater individualization of treatment. However, there is substantial SUV variation by anatomic site. In this retrospective, single-institution study, we examine baseline SUV on PET/CT as a predictor of outcome from MBC. Methods: Patients (Pts) with ≥1 metastatic lesion on PET/CT performed ≤60 days of diagnosis of MBC from 01/01/2001-12/31/2008 were identified through institutional databases. Pts who rcv

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Müller, Martin C., Benjamin Hanfstein, Michael Lauseker, et al. "Time-Related Interpretation of Molecular Response Levels According to Long Term Overall and Progression-Free Survival of CML Patients on First-Line Imatinib Treatment." Blood 118, no. 21 (2011): 1681. http://dx.doi.org/10.1182/blood.v118.21.1681.1681.

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Abstract Abstract 1681 Introduction: The prognostic impact of different levels of molecular remission (BCR-ABL transcript expression according to International Scale, IS) at various time points on survival under imatinib treatment is still unclear. Whereas recently published data from the IRIS trial described relevant milestones at 6, 12, and 18 months for event-free and progression-free survival (PFS; Hughes et al., Blood 2010), little is known about an association of molecular response with overall survival (OS). The aim of this evaluation of the German CML Study IV was to elucidate the risk

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MCCRAW, R. "Baby basics Color, sound, 120 minutes. Produced and directed by Adrienne Miesmer. Written and co-produced by Lisa McElaney, 1987. Available in -inch VHS videocassette format from Vida Health Communications, 22 Riverview Drive, Wayne, NJ 07470. (201) 628-9111 or (800) 524-1013. Purchase price $39.95 plus $3.50 shipping and handling. Massachusetts residents add $2.00 sales tax. 24-page index and companion booklet included. The video plus accompanying materials are available in English and Spanish." Journal of Nurse-Midwifery 34, no. 4 (1989): 225–26. http://dx.doi.org/10.1016/0091-2182(89)90101-8.

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Galsky, Matt D., Dean F. Bajorin, J. Alfred Witjes, et al. "Analysis of disease-free survival in CheckMate 274 by PD-L1 combined positive score and tumor proportion score." Journal of Clinical Oncology 40, no. 6_suppl (2022): 491. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.491.

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491 Background: CheckMate 274 demonstrated a significant improvement in disease-free survival (DFS) with nivolumab (NIVO) versus placebo (PBO) both in the intent-to-treat population (hazard ratio [HR], 0.70; 98.22% confidence interval [CI], 0.55–0.90; P < 0.001) and in patients (pts) with tumor programmed death ligand 1 (PD-L1) expression ≥ 1% assessed by the tumor proportion score (TPS) (HR, 0.55; 98.72% CI, 0.35–0.85; P < 0.001). An exploratory subgroup analysis showed a trend toward a DFS benefit with NIVO in pts with TPS < 1% (0.82; 95% CI, 0.63–1.06). To further characterize the

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Tu, Tsung-Hsi, Chao-Hung Kuo, Wen-Cheng Huang, Li-Yu Fay, Henrich Cheng, and Jau-Ching Wu. "Effects of smoking on cervical disc arthroplasty." Journal of Neurosurgery: Spine 30, no. 2 (2019): 168–74. http://dx.doi.org/10.3171/2018.7.spine18634.

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OBJECTIVECigarette smoking can adversely affect bone fusion in patients who undergo anterior cervical discectomy and fusion. However, there is a paucity of data on smoking among patients who have undergone cervical disc arthroplasty (CDA). The present study aimed to compare the clinical and radiological outcomes of smokers to those of nonsmokers following CDA.METHODSThe authors retrospectively reviewed the records of consecutive patients who had undergone 1- or 2-level CDA for cervical disc herniation or spondylosis and had a minimum 2-year follow-up. All patients were grouped into a smoking g

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Schultz, Nicolai Aagaard, Ib Jarle Christensen, Jens Werner, et al. "Pretreatment plasma concentrations of YKL-40 and IL-6 in patients with pancreatic cancer: Potential diagnostic and prognostic biomarkers." Journal of Clinical Oncology 31, no. 4_suppl (2013): 164. http://dx.doi.org/10.1200/jco.2013.31.4_suppl.164.

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164 Background: To test the hypothesis that high pretreatment plasma YKL-40 and IL-6 associate with pancreatic cancer (PC) and short overall survival (OS). Methods: 556 patients with PC from Denmark (N=445) and Germany (N=111) were included in the present prospective biomarker study. 152 (27%) patients were operated and treated postoperative with adjuvant gemcitabine. 404 (73%) had locally advanced or metastatic PC and received palliative chemotherapy (primarily gemcitabine). Pretreatment plasma YKL-40 and IL-6 were determined by ELISA with known reference intervals in healthy subjects. Result

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MCCRAW, R. "Your child has a fever Color, sound, 15 minutes. Written and produced by Richard Usatine and Martin Smietanka, 1985. Available from Churchill Films, 662 North Robertson Blvd., Los Angeles, CA 90069. (213) 657–5110. Purchase price: $235.00 plus $2.00 postage and handling for video formats; not available in 16-mm film. Available for rental from Audience Planners, Inc., 5107 Douglas Fir Road, Calabasas, CA 91302. (800) 624–8613. Rental price: $60.00 (3-day). Brief discussion guide included." Journal of Nurse-Midwifery 34, no. 1 (1989): 53–54. http://dx.doi.org/10.1016/0091-2182(89)90137-7.

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Waterhouse, David, Saurabh Ray, Keith A. Betts, et al. "Abstract 3819: Real-world long-term survival outcomes of first-line immunotherapy-based regimens in advanced non-small cell lung cancer." Cancer Research 84, no. 6_Supplement (2024): 3819. http://dx.doi.org/10.1158/1538-7445.am2024-3819.

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Abstract Background: The real-world survival outcomes of first-line (1L) immunotherapy (IO)-based regimens for the treatment of advanced non-small cell lung cancer (aNSCLC) were assessed utilizing the Flatiron Health database from January 2011 to June 2023. Methods: Adult patients (pts) with aNSCLC receiving 1L IO monotherapy or single-agent IO + chemotherapy on or after January 1, 2016, were identified. Pts were excluded if they had EGFR/ALK mutations or unknown histological type. Overall survival (OS) and real-world progression-free survival (rwPFS) of 1L IO monotherapy and IO + chemotherapy

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MCCRAW, R. "Infant care: The first weeks Color, sound, 22 minutes. Produced and directed by Linda Jassim, 1987. Available for purchase in 16-mm film and all video formats from Churchill Films, 662 North Robertson Blvd., Los Angeles, CA 90069. (213) 657–5110. Purchase price: $330.00 plus $2.00 postage and handling for video; $440.00 plus $4.00 postage and handling for 16-mm film. Available for rental from Audience Planners, Inc., 5107 Douglas Fir Road, Calabasas, CA 91302. (800) 624–8613. Rental price: $60.00 (3-day). Brief discussion guide included." Journal of Nurse-Midwifery 34, no. 1 (1989): 53. http://dx.doi.org/10.1016/0091-2182(89)90136-5.

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Smoljanić, Jovana, Nathan B. Morris, Sheila Dervis, and Ollie Jay. "Running economy, not aerobic fitness, independently alters thermoregulatory responses during treadmill running." Journal of Applied Physiology 117, no. 12 (2014): 1451–59. http://dx.doi.org/10.1152/japplphysiol.00665.2014.

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We sought to determine the independent influence of running economy (RE) and aerobic fitness [maximum oxygen consumption (V̇o2max)] on thermoregulatory responses during treadmill running by conducting two studies. In study 1, seven high (HI-FIT: 61 ± 5 ml O2·kg−1·min−1) and seven low (LO-FIT: 45 ± 4 ml O2·kg−1·min−1) V̇o2max males matched for physical characteristics and RE (HI-FIT: 200 ± 21; LO-FIT: 200 ± 18 ml O2·kg−1·km−1) ran for 60 min at 1) 60%V̇o2max and 2) a fixed metabolic heat production (Hprod) of 640 W. In study 2, seven high (HI-ECO: 189 ± 15.3 ml O2·kg−1·km−1) and seven low (LO-E

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Corash, Laurence, Fabrice Cognasse, Jean-Claude Osselaer, Natalie Messe, and Olivier Garraud. "Release of Immune Modulation Factors from Platelet Concentrates during Storage after Photochemical Pathogen Inactivation." Blood 108, no. 11 (2006): 941. http://dx.doi.org/10.1182/blood.v108.11.941.941.

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Abstract Background. Platelets (plt) prepared for transfusion contain multiple molecules that modulate immune function, mediate acute transfusion reactions, induce immune responses, and affect hemostasis. These cytokines/chemokines are secreted differentially from plt during storage (Transfusion2006;46:1184), and may be affected by processing, including pathogen inactivation. Aims. The INTERCEPT Blood System (IBS) for platelets utilizes amotosalen-HCl (S-59) with ultraviolet A (UVA) light to inactivate a broad spectrum of pathogens and leukocytes. This study was designed to evaluate the effect

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MCCRAW, R. "AIDS: Issues for healthcare workers Color, sound, 23 minutes. Produced and directed by Leslie Hill, 1988. Available for purchase in 16-mm and all video formats from Churchill Films, 662 North Robertson Boulevard, Los Angeles, CA 90069. (213) 657-5110. Purchase price: $295.00 plus $2.00 postage and handling for video formats; $395.00 plus $4.00 postage and handling for 16-mm film. Available for rental from Audience Planners, Inc., 5107 Douglas Fir Road, Calabasas, CA 91302. (800) 624-8613. Rental price: $60.00 for 3-day rental. Brief discussion guide included." Journal of Nurse-Midwifery 34, no. 3 (1989): 155. http://dx.doi.org/10.1016/0091-2182(89)90067-0.

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Bower, H., T. Frisell, D. DI Giuseppe, B. Delcoigne, and J. Askling. "OP0133 DO JAKIS WORK THE BEST AMONG THOSE RA PATIENTS WHERE THEIR SAFETY CONCERNS ARE THE HIGHEST?" Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 88.1–88. http://dx.doi.org/10.1136/annrheumdis-2023-eular.346.

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BackgroundSafety is a driving factor when selecting treatment, but the risks should be balanced against the treatment benefits, relative to alternative treatment options. In JAKis, recent evidence of increased safety risks in older patients with cardiovascular (CV) risk factors, have led to concerns. However, an increased risk among certain patients might still be offset by an increasing benefit in the same patient segment, and vice versa. A full understanding of the JAKi benefit-risk profile thus requires a better understanding of the relative (JAKi vs other treatments) benefits in those pati

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Marzo-Ortega, H., X. Juanola, T. Okano, et al. "POS0926 NORMALIZATION OF HIGH SENSITIVITY CRP VERSUS CLINICAL RESPONSE TO IXEKIZUMAB AT WEEK 16 IN PATIENTS WITH RADIOGRAPHIC & NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: RESULTS FROM THE COAST STUDIES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 725–26. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2079.

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Background:C-reactive protein (CRP), an objective marker of inflammation, can be used to monitor treatment response to biologics in patients with axial spondyloarthritis (axSpA) in addition to evaluating signs & symptoms. CRP is not elevated in all patients with active axSpA questioning its validity as a universal biomarker of response. Ixekizumab (IXE) demonstrated efficacy in axSpA treatment irrespective of baseline (BL) CRP levels. However, response to IXE categorized on CRP change from BL is unknown.Objectives:To evaluate response to IXE treatment from BL through week (wk) 16 in patien

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Flowers, Christopher R., Michael Lill, Luciano J. Costa, et al. "Efficacy Of a Pharmacokinetics-Directed IV Busulfan (Bu), Plus Cyclophosphamide (Cy) and Etoposide (E) Preparative Regimen With Autologous Hematopoietic Stem Cell Transplantation For Lymphoma: Final Report Of a Multi-Center Phase 2 Study In North America." Blood 122, no. 21 (2013): 768. http://dx.doi.org/10.1182/blood.v122.21.768.768.

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Abstract Background Bu-based conditioning regimens are commonly used prior to autologous hematopoietic stem cell transplantation (ASCT) for lymphoma, but clinical results of an intravenous (IV) Bu-based regimen have been limited to single center studies. This multi-center, single-arm, Phase 2 study prospectively evaluated the safety and efficacy of the IV BuCyE regimen in lymphoma patients undergoing ASCT. Methods The primary endpoint was progression-free survival (PFS). Secondary endpoints included overall survival (OS), transplant-related mortality (TRM) and overall response rate. TRM was de

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De Montalembert, Mariane, Frédéric Galacteros, Jean Antoine Ribeil, et al. "Implementation of a European Cohort to Follow Sickle Cell Children and Adults Treated with Hydroxycarbamide." Blood 124, no. 21 (2014): 564. http://dx.doi.org/10.1182/blood.v124.21.564.564.

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Abstract Hydroxycarbamide (HU) is a myelosuppressive drug marketed since 1968 for the treatment of hematological cancer, and authorized since 2007 in Europe as orphan medicinal product for the prevention of recurrent vaso-occlusive crises including acute chest syndrome in adults and children older than 2 years with sickle cell disease (SCD). ESCORT-HU (European Sickle Cell Disease Cohort – Hydroxyurea) is a multicenter prospective non interventional study implemented in Europe to collect more information about the safety profile of HU and morbi-mortality in SCD patients treated with HU. The st

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García-Gutiérrez, Valentín, Dragana Milojkovic, María Luisa Martín Mateos, et al. "Safety and Efficacy of Bosutinib in Fourth Line Therapy of Chronic Myeloid Leukemia Patients." Blood 126, no. 23 (2015): 2786. http://dx.doi.org/10.1182/blood.v126.23.2786.2786.

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Abstract BACKGROUND: Despite the excellent prognostic of chronic myeloid leukemia (CML) patients since the introduction of tyrosine kinase inhibitors (TKIs), approximately 50% of patients that are treated with TKIs will discontinue first line treatment due to lack of efficacy or intolerance. Once patients need a second line treatment, a considerable proportion of patients will need third or even fourth line therapy during further evolution. At this moment, there is a lack of data about real benefit of this group of patients. We have recently published our experience of 30 CML patients treated

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Nair, Chandran K., Lingaraj Nayak, Anu Korula, et al. "Impact of Consolidation Radiotherapy in Bulky Diffuse Large B Cell Lymphoma By PET Based Response Assessment." Blood 144, Supplement 1 (2024): 3078. https://doi.org/10.1182/blood-2024-203645.

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The prognostic significance of bulky disease at baseline and the role of routine consolidation radiotherapy (RT) in such cases of diffuse large B cell lymphoma(DLBCL) in Positron Emission Tomography ( PET) era is not very clear. In the landmark MabThera International Trial(MInT trial), RT was administered to all patients with initial bulky disease. The 3 year event free survival(EFS) and overall survival(OS) were inferior in the group with bulk compared to no bulk ( EFS 52 % versus 78 % , OS 81% versus 92%). However the response assessment in this study was not PET-based. A retrospective study

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Yoon, Shinkyo, Dok Hyun Yoon, Shin Kim, et al. "Proposal of New Prognostic Index for Patients with Diffuse Large B-Cell Lymphoma in the Rituximab Era." Blood 124, no. 21 (2014): 1668. http://dx.doi.org/10.1182/blood.v124.21.1668.1668.

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Abstract Background The International Prognostic Index (IPI) has been useful prognostic tool to predict prognosis of aggressive non-Hodgkin lymphoma in the last 20 years. Since the advent of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) chemotherapy for diffuse large B-cell lymphoma (DLBCL), its utility has been challenged and other prognostic index including revised IPI and National Comprehensive Cancer Network (NCCN)-IPI were proposed, which are not popularly used yet. We aimed to develop new prognostic model for DLBCL in rituximab era. Method Between March 2

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Sesin, C., G. Gallo, A. Gellett, et al. "POS1033 SAFETY OF IXEKIZUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS: AN INTEGRATED ANALYSIS OF 4 CLINICAL TRIALS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 789.1–789. http://dx.doi.org/10.1136/annrheumdis-2021-eular.567.

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Background:Patients with psoriatic arthritis (PsA) require long-term treatment, which may lead to adverse events (AEs). Ixekizumab, an interleukin-17A antagonist, is approved for the treatment of adults with active PsA.Objectives:We report a summary of safety outcomes for patients enrolled in 4 PsA studies with up to 3 years of exposure to ixekizumab.Methods:This integrated safety analysis included all patients with PsA who received at least 1 dose of ixekizumab (80 mg every 2 or 4 weeks) in 4 clinical trials (NCT01695239, NCT02349295, NCT02584855, NCT03151551). Safety outcomes included treatm

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Soleto, C. Y., B. Serrano Benavente, L. A. Torrens Cid, et al. "AB0357 USE OF TOFACITINIB AND REASONS FOR DISCONTINUATION IN CLINICAL PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1478.2–1479. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5789.

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Background:Tofacitinib is an oral JAK 1 and 3 inhibitor for the treatment of moderate to severe active rheumatoid arthritis (RA) or psoriatic arthritis (PsA) in adults with inadequate response or intolerant to one or more conventional disease-modifying antirheumatic drugs (cDMARDs). Since its approval by the European Medicines Agency (EMA), there is limited data about its use in daily practice in Europe.Objectives:To describe rates and reasons for discontinuation of Tofacitinib in patients with RA and other inflammatory conditionsMethods:We identified patients with a prescription for tofacitin

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Mukherjee, Sudipto, Chandana Reddy, Jay Ciezki, et al. "Radiation Treatment for Localized Prostate Cancer and the Risk of Developing Myelodysplastic Syndromes (MDS)." Blood 118, no. 21 (2011): 120. http://dx.doi.org/10.1182/blood.v118.21.120.120.

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Abstract Abstract 120 Background: Both environmental radiation exposure and use of therapeutic radiation (XRT) in primary solid tumor malignancies increase the risk of secondary MDS. No data exist on the risk of developing secondary MDS in prostate cancer patients (pts) being treated with radiotherapy. Establishing this risk has important clinical implications, as prostate cancer is the leading cancer in men and radiation therapy has increasingly become the preferred modality for treatment of localized prostate cancer. Methods: We performed a prospective case control study of 11,015 pts with l

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Chen, Xue, Lili Yuan, Xiaoli Ma, et al. "Extensive Fusion Gene Profiling in Acute Myeloid Leukemia Revealed By Whole Transcriptome Sequencing of 1614 Cases." Blood 144, Supplement 1 (2024): 4326. https://doi.org/10.1182/blood-2024-193221.

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Background Fusion genes (FGs) are critical molecular abnormalities in acute myeloid leukemia (AML), serving as vital markers for diagnosis, classification, risk stratification, and targeted therapy. In 2021, we published the FG map of acute leukemia revealed by whole transcriptome sequencing (WTS) of 1000 cases, including 539 AML patients (Blood Cancer Journal. PMID: 34135310). Building upon this initial study, we have now expanded our study to include 1614 AML cases, aiming to further elucidate the FG landscape and explore additional insights into the clinical implications of these genetic al

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Williams, Annalynn M., Andrea M. Baran, Philip J. Meacham, et al. "High Risk of Infections in Chronic Lymphocytic Leukemia Patients Treated with B-Cell Receptor Inhibitors." Blood 128, no. 22 (2016): 3203. http://dx.doi.org/10.1182/blood.v128.22.3203.3203.

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Abstract Introduction: Infection is a major source of morbidity and mortality in CLL. Improved treatment efficacy and decreased immune toxicity of treatment could have altered the spectrum and consequences of infections in patients with CLL. A better understanding of infections complicating the course of non-selected patients with CLL could be useful in improving medical management. Methods: Demographic and clinical information was retrospectively extracted from medical records for clinic visits between May 1st, 2000 and May 1st, 2016 for all patients enrolled in the Wilmot Cancer Institute (W

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Rivera, Daniel, Yesid Alvarado, Guillermo Garcia-Manero, Gautham Borthakur, Hagop Kantarjian, and Sergej Konoplev. "Clinical Characteristics and Outcomes of Patients Diagnosed with Acute Myeloid Leukemia with Expression of CD71." Blood 138, Supplement 1 (2021): 4449. http://dx.doi.org/10.1182/blood-2021-151023.

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Abstract Introduction Acute myeloid leukemia (AML) is a clonal hematologic malignancy characterized by the proliferation and accumulation of blasts in the bone marrow (BM) which results in hematopoietic failure. Transferrin receptor (CD71) plays an important role by up-taking iron into the cell, and its expression is regulated by cellular iron levels. Recently, CD71 has emerged as a sensitive and specific marker of cell proliferation in solid tumors. The clinical significance of CD71 expression in AML remains unclear. Current efforts are also exploring its potential as a therapeutic target in

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Olszewski, Adam J., and Jorge J. Castillo. "Prognosis of HIV-Associated Hodgkin Lymphoma in the Antiretroviral Therapy Era: Analysis of the National Cancer Data Base (NCDB)." Blood 126, no. 23 (2015): 3861. http://dx.doi.org/10.1182/blood.v126.23.3861.3861.

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Abstract Background: The incidence of Hodgkin lymphoma (HL) among HIV-positive (HIV+) patients remains high despite the use of antiretroviral therapy. HIV+HL is characterized by a higher prevalence of the mixed cellularity (MC) subtype and by expression of Epstein-Barr virus-encoded genes. Despite poor historical outcomes, recent studies show similar overall survival (OS) among HIV+ and HIV-negative HL patients who receive standard therapy. We examined the actual proportions of HIV+HL patients receiving chemotherapy in the United States (US), and their OS, using the NCDB-a clinical oncology da

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