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Journal articles on the topic '65.012.34 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Rogers, Jonathan, Camarie Welgemoed, and Dorothy Gujral. "Does body mass index or subcutaneous adipose tissue thickness affect interfraction prostate motion in patients receiving radical prostate radiotherapy?" Journal of Radiotherapy in Practice 15, no. 4 (2016): 334–40. http://dx.doi.org/10.1017/s1460396916000364.

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AbstractAimIt is unclear whether body mass index (BMI) is a useful measurement for examining prostate motion. Patient’s subcutaneous adipose tissue thickness (SAT) and weight has been shown to correlate with prostate shifts in the left/right direction. We sought to analyse the relationship between BMI and interfraction prostate movement in order to determine planning target volume (PTV) margins based on patient BMI.Materials and methodsIn all, 38 prostate cancer patients with three implanted gold fiducial markers in their prostate were recruited. Height, mass and SAT were measured, and the ext

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Kantarjian, Hagop M., Alfonso Quintas-Cardama, Susan O’Brien, et al. "Importance of Early Intervention with Dasatinib at Cytogenetic Rather Than Hematologic Resistance to Imatinib." Blood 110, no. 11 (2007): 1036. http://dx.doi.org/10.1182/blood.v110.11.1036.1036.

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Abstract Recent data for patients with chronic-phase (CP) CML indicate that development of resistance or intolerance to imatinib and treatment intervention following progression to advanced-phase disease are both associated with poor clinical outcome (with 3-year survival rates of 72% for chronic-phase disease, 30% for accelerated-phase CML, and 7% for blast-phase CML) (Kantarjian et al. Cancer2007;109:1556–60). Results also demonstrate that intervention with a second-generation tyrosine kinase inhibitor is more effective for individuals with chronic-phase CML than for those with advanced-phas

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Sonneveld, Pieter, Ingo G. H. Schmidt-Wolf, Bronno van der Holt, et al. "Bortezomib Induction and Maintenance Treatment in Patients With Newly Diagnosed Multiple Myeloma: Results of the Randomized Phase III HOVON-65/ GMMG-HD4 Trial." Journal of Clinical Oncology 30, no. 24 (2012): 2946–55. http://dx.doi.org/10.1200/jco.2011.39.6820.

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Purpose We investigated whether bortezomib during induction and maintenance improves survival in newly diagnosed multiple myeloma (MM). Patients and Methods In all, 827 eligible patients with newly diagnosed symptomatic MM were randomly assigned to receive induction therapy with vincristine, doxorubicin, and dexamethasone (VAD) or bortezomib, doxorubicin, and dexamethasone (PAD) followed by high-dose melphalan and autologous stem-cell transplantation. Maintenance consisted of thalidomide 50 mg (VAD) once per day or bortezomib 1.3 mg/m2 (PAD) once every 2 weeks for 2 years. The primary analysis

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Дидоренко, Светлана, Эльмира Кисетова, Ринат Касенов, Жасулан Байжанов, Рыстай Кушанова та Исламбек Сагит. "ПРОДУКТИВНОСТЬ И КАЧЕСТВО СОРТОВ СОИ СОЗДАННЫХ НА РАЗНЫХ ЭТАПАХ СЕЛЕКЦИОННЫХ РАБОТ В КАЗАХСКОМ НАУЧНО – ИССЛЕДОВАТЕЛЬСКОМ ИНСТИТУТЕ ЗЕМЛЕДЕЛИЯ И РАСТЕНИЕВОДСТВА". Izdenister natigeler, № 2-1 (special) (29 червня 2024): 85–98. http://dx.doi.org/10.37884/2-1-2024/542.

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В 2021 году площадь посевов сои в Республике Казахстан составила 113,3 тыс. га, а в 2022 году - 128,0 тыс. га с валовым сбором зерна - 250,4 тыс. тонн. В последние годы в посевах сои в стране доля отечественных сортов составляла от 55 до 65 %. Лидером по величине посевных площадей сои является Алматинская область, где сосредоточено 83,6 % посевов (94,7 тысяч гектар); далее следует Костанайская – 7,7 % (8,8 тыс. га); Восточно-Казахстанская – 5 % (5,6 тыс. га); Северо-Казахстанская – 2,8 % (3,2 тыс. га); Туркестанская – 0,1 % (0,2-0,3 тыс. га); и другие области. За годы селекционной работы в Каз

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Collette, Christopher, Amani M. Norling, Randall A. Walden, et al. "30 Hippocampal Internal Architecture Subfield Volumes Associated with Systematic Inflammatory Biomarkers in Multiple Sclerosis." Journal of the International Neuropsychological Society 29, s1 (2023): 546–47. http://dx.doi.org/10.1017/s1355617723007014.

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Objective:Multiple Sclerosis (MS) affects up to 500,000 adults in the United States, with cognitive impairment present in 45%-65% of people. Studies showed hippocampal atrophy in MS, but the underlying mechanisms remain unknown. Inflammation has been proposed to play a significant role, and associations between systemic inflammatory biomarkers and hippocampal atrophy have been shown in other neurological conditions. However, research exploring serum biomarker and volumetric associations in MS are lacking. Given that conventional imaging methods lack resolution for hippocampal internal architec

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ศรีโกไสย, สุนทรี, อุไรวรรณ วงศ์โปธิ, ณัฏฐ์พิมล วงศ์เมือง та อนงค์พร ต๊ะคำ. "การพัฒนาระบบบริการสุขภาพจิตผู้ปกครองของเด็กและวัยรุ่นที่มีปัญหาสุขภาพจิตและพัฒนาการ". Journal of Thailand Nursing and Midwifery Council 38, № 02 (2023): 88–104. http://dx.doi.org/10.60099/jtnmc.v38i02.261791.

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บทนำ ที่ผ่านมายังไม่มีระบบที่ชัดเจนในการบริการสุขภาพจิตผู้ปกครอง และการคัดกรองยังไม่ครอบคลุม มีข้อจำกัดในการเข้าถึงบริการของผู้ปกครองที่มีปัญหาสุขภาพจิต รวมทั้งความเชื่อมโยงระหว่างหน่วยบริการ วัตถุประสงค์การวิจัย เพื่อพัฒนาระบบบริการสุขภาพจิตผู้ปกครองของเด็กและวัยรุ่นที่มีปัญหาสุขภาพจิต และพัฒนาการ ทดสอบประสิทธิภาพและประสิทธิผลของโปรแกรมการบำบัดสังคมจิตใจแบบสั้นแนวซาเทียร์โมเดล การออกแบบวิจัย การวิจัยและพัฒนา วิธีดำเนินการวิจัย การวิจัยแบ่งเป็น 5 ระยะ ทำการศึกษาระหว่าง มกราคม 2563 - ธันวาคม 2565 ระยะที่ 1 วิเคราะห์ ความต้องการความจำเป็น ระยะที่ 2 ออกแบบระบบบริการสุขภาพจิตผู้ปกครอง ระยะที่ 3 สร

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Nurse, Daniel P., Wei Wei, Amanda Burns, et al. "Assessment of Secondary Malignancies after Allogeneic Hematopoietic Cell Transplant When Comparing Treatment with and without Post-Transplant Cyclophosphamide." Blood 144, Supplement 1 (2024): 7383. https://doi.org/10.1182/blood-2024-202626.

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Introduction Secondary malignancies (SM) may occur as a late toxicity after allogeneic hematopoietic cell transplant (alloHCT) and result in significant morbidity and mortality. It is currently unknown what effect the use of post-transplant cyclophosphamide (PTCy) may have on the development of SM. The primary objective of this study was to compare the incidence of SM after alloHCT between patients treated with and without PTCy. Methods We conducted a single-center retrospective cohort study of 1,124 patients who underwent alloHCT from 2011 to 2021. Time to the development of SM (ttSM) was cal

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Ortiz, Johana, John Van Camp, Sylviana Wijaya, Silvana Donoso, and Lieven Huybregts. "Determinants of child malnutrition in rural and urban Ecuadorian highlands." Public Health Nutrition 17, no. 9 (2013): 2122–30. http://dx.doi.org/10.1017/s1368980013002528.

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AbstractObjectiveTo identify and compare the sociodemographic determinants of stunting, wasting and overweight among infants of urban and rural areas in the Ecuadorian highlands.DesignCross-sectional study.SettingNabon (rural) and Cuenca (urban) cantons, Azuay Province, Ecuador.SubjectsA total of 703 children aged 0–24 months and their caregivers (227 rural and 476 urban) recruited during the period from June to September 2008.ResultsStunting prevalence was significantly higher in the rural area (37·4 %v. 17·7 %;P< 0·001) while wasting (7·1 %) and overweight (17·1 %) prevalence were more si

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Palumbo, Antonio, Meletios A. Dimopoulos, Katja Weisel, et al. "Outcomes for Older Patients in Stratus (MM-010), a Single-Arm, and Phase 3b Study of Pomalidomide + Low-Dose Dexamethasone in Refractory or Relapsed and Refractory Multiple Myeloma." Blood 124, no. 21 (2014): 4770. http://dx.doi.org/10.1182/blood.v124.21.4770.4770.

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Abstract Background: Survival of patients (pts) with multiple myeloma (MM) decreases with increased age (Pulte, Oncologist, 2011). In addition, MM pts with advanced disease who have exhausted treatment (Tx) with novel agents have a poor prognosis (Kumar, Leukemia, 2012). Pomalidomide (POM) is a new oral agent with antimyeloma, stromal cell inhibitory, and immune modulatory effects (Quach, Leukemia, 2010; Mark, Leuk Res, 2014). In the pivotal MM-003 trial, POM in combination with low-dose dexamethasone (LoDEX) demonstrated significant progression-free survival (PFS) and overall survival (OS) be

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Kunte, Siddharth Jayant, Lisa Rybicki, Auro Viswabandya, et al. "Haploidentical Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide in Patients with Myelofibrosis: A Multi-Institutional Experience." Blood 136, Supplement 1 (2020): 33–34. http://dx.doi.org/10.1182/blood-2020-136622.

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Background: Primary and secondary [post-essential thrombocythemia (ET) or polycythemia vera (PV)] Myelofibrosis (MF) are clonal hematopoietic neoplasms marked by constitutive JAK-STAT activation, bone marrow fibrosis, cytopenias, and constitutional symptom burden. Allogeneic hematopoietic cell transplantation (HCT) is the only curative option in this disease. Median overall survival (OS) after JAK inhibitor (JAKi) discontinuation is poor, ranging from 6-24 months (Harrision et al. Ann Hematol. 2020). Haploidentical (Haplo)-HCT with post-transplant cyclophosphamide (PTCy) has improved donor ava

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Mandel, Philipp, Benedikt Hoeh, Carolin Siech, et al. "Lutetium-177 PSMA radioligand therapy in taxan-naive first- and second-line metastatic castration resistant prostate cancer after first-line ARPI therapy." Journal of Clinical Oncology 43, no. 5_suppl (2025): 79. https://doi.org/10.1200/jco.2025.43.5_suppl.79.

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79 Background: Lutetium-177 Prostate-specific membrane antigen (Lu-PSMA) radioligand therapy is EMA-approved for metastatic castration resistant prostate cancer (mCRPC) after androgen receptor pathway inhibition (ARPI) and taxane-based chemotherapy. However, its effect in taxane-naïve patients is under current investigation. Methods: We relied on the FRAMCAP database to elaborate Lu-PSMA therapy outcomes of progression-free (PFS) and overall (OS) in taxane-naïve mCRPC patients after previous ARPI treatment. Comparison was made against current standard of care with ARPI or docetaxel. Results: O

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Phillips, Gregory S., Jennifer Wu, Matthew D. Hellmann, et al. "Treatment Outcomes of Immune-Related Cutaneous Adverse Events." Journal of Clinical Oncology 37, no. 30 (2019): 2746–58. http://dx.doi.org/10.1200/jco.18.02141.

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PURPOSE The aim of the current study was to report the efficacy of topical and systemic treatments for immune-related cutaneous adverse events (ircAEs) attributed to checkpoint inhibitors in an uncontrolled cohort of patients referred to oncodermatology clinics. METHODS A retrospective analysis of patients with ircAEs evaluated by dermatologists from January 1, 2014, to December 31, 2017, at three tertiary care hospitals and cancer centers were identified through electronic medical records. Clinicopathologic characteristics, dermatologic therapy outcome, and laboratory data were analyzed. RESU

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Liao, Wei, Matthew Paul Smeltzer, Jordan Goss, et al. "Lung cancer diagnosis rates (LCDR) in lung cancer screening (LCS) and incidental pulmonary nodule (IPN) cohorts in the Mississippi Delta." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8002. https://doi.org/10.1200/jco.2025.43.16_suppl.8002.

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8002 Background: The LCDR in the CT screened cohort in the National Lung Screening Trial (NLST) was 1.1% over a median of 6.5 years follow up. We evaluated the LCDR in a regional US community. Methods: Prospective cohort study of patients in LCS and IPN programs in 22 facilities across a 125 county service area population. We compared LCDR over 3 years in LCS stratified by Lung-RADS (L-R) score (1 to 4X), IPN by nodule size (≤6, >6-15, >15-20, >20-30 mm) on initial CT scans. Comparisons used Chi-square tests, Wilcoxon tests, and Cox regression models with Hazard Ratios (HR) for lung c

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Boyer, Patricia M., Gabriela E. Compagnucci, María I. Olivera, et al. "Bone status in an animal model of chronic sub-optimal nutrition: a morphometric, densitometric and mechanical study." British Journal of Nutrition 93, no. 5 (2005): 663–69. http://dx.doi.org/10.1079/bjn20041331.

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In children, inappropriate eating habits can induce a disease known as nutritional dwarfing (ND). Due to the link between nutritional condition and bone growth, the effects induced by a 20 % reduction of food intake on bone competence were assessed in an animal model of ND. Bone status during catch-up growth was also analysed. Male Wistar rats were divided into control (C) and ND groups. C rats were fed ad libitum. ND received 80 % of the diet consumed by C for 4 weeks (T4); thereafter, they were fed ad libitum for 8 weeks. Results, expressed as mean (sem) for ND v. C, were as follows. At T4,

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Lewis, O'Dene, Julius Ngwa, Richard F. Gillum, et al. "Incidence, Risk Factors and Outcomes of New Onset Supraventricular Arrhythmias in African American Patients with Severe Sepsis." Ethnicity & Disease 26, no. 2 (2016): 205. http://dx.doi.org/10.18865/ed.26.2.205.

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<p><strong>Purpose</strong>: New onset supraventricular arrhythmias (SVA) are commonly reported in mixed intensive care settings. We sought to determine the incidence, risk factors and outcomes of new onset SVA in African American (AA) patients with severe sepsis admitted to medical intensive care unit (MICU).</p><p><strong>Methods:</strong> Patients admitted to MICU between January 2012 through December 2012 were studied. Patients with a previous history of arrhythmia or with new onset of ventricular arrhythmia were excluded. Data on risk factors, cri

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Chian, Deping, François Marillier, Jeremy Hall, and Garry Quinlan. "An improved velocity model for the crust and upper mantle along the central mobile belt of the Newfoundland Appalachian orogen and its offshore extension." Canadian Journal of Earth Sciences 35, no. 11 (1998): 1238–51. http://dx.doi.org/10.1139/e98-042.

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New modelling of wide-angle reflection-refraction data of the Canadian Lithoprobe East profile 91-1 along the central mobile belt of the Newfoundland Appalachian orogen reveals new features of the upper mantle, and establishes links in the crust and upper mantle between existing land and marine wide-angle data sets by combining onshore-offshore recordings. The revised model provides detailed velocity structure in the 30-34 km thick crust and the top 30 km of upper mantle. The lower crust is characterized by a velocity of 6.6-6.8 km/s onshore, increasing by 0.2 km/s to the northeast offshore be

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Sayegh, Nicolas, Yeonjung Jo, Zeynep Irem Ozay, et al. "Evaluation of time to metastasis (TTM) from prostatectomy and survival in patients (pts) with metachronous metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen deprivation therapy (ADT) intensification: A real-world study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 100. https://doi.org/10.1200/jco.2025.43.5_suppl.100.

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100 Background: Metachronous mHSPC is associated with improved outcomes compared to synchronous (de novo) mHSPC. However, there are limited data on the effect of TTM after radical prostatectomy in patients with metachronous mHSPC treated with systemic therapies. Our objective was to explore the association of TTM after prostatectomy with survival outcomes in a real-world population. Methods: In this IRB-approved retrospective study, eligibility criteria were: pts with metachronous mHSPC who underwent radical prostatectomy and were treated with ADT plus androgen receptor pathway inhibitor (ARPI

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Patnaik, Mrinal M., Emnet A. Wassie, Eric Padron, et al. "Chronic Myelomonocytic Leukemia in Young Patients: Molecular and Cytogenetic Predictors of Survival and Treatment Outcome." Blood 124, no. 21 (2014): 4633. http://dx.doi.org/10.1182/blood.v124.21.4633.4633.

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Abstract Background: Most patients with chronic myelomonocytic leukemia (CMML) are elderly and age >65 years is an adverse prognostic factor (JCO 2013;31:2428). Our objective in the current study was to examine risk factors for survival and treatment outcome in younger patients (age ≤65 years), with emphasis on molecular and cytogenetic markers. Methods: DNA analysis for SRSF2, SF3B1, U2AF1, ASXL1 and SETBP1 mutations was carried out on specimens obtained at time of diagnosis. We used both conventional and revised (see accompanying ASH 2014 abstract) cytogenetic risk models to query their a

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Yang, Luxi, Le Shu, Junyi Jiang, et al. "Long-term effect of dietary fibre intake on glycosylated haemoglobin A1c level and glycaemic control status among Chinese patients with type 2 diabetes mellitus." Public Health Nutrition 17, no. 8 (2013): 1858–64. http://dx.doi.org/10.1017/s1368980013002000.

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AbstractObjectiveDietary fibre has been linked to lower levels of glycosylated haemoglobin A1c (HbA1c) among diabetes patients. The present study aimed to evaluate the long-term effect of dietary fibre on HbA1c levels among Chinese patients with type 2 diabetes mellitus.DesignTwo cross-sectional surveys were conducted in 2006 and 2011, with the second one being a repeat survey on a sub-sample from the initial one. In both surveys, an in-person interview was conducted to collect information on demographic characteristics and lifestyles following a similar protocol. Dietary intake was assessed w

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Tozatto-Maio, Karina, Viktoria Weihermann, Carolina Wermelinger Erthal, et al. "Dengue Fever Outbreak in Brazil: Outcomes of 34 Adults with Underlying Hematological Diseases." Blood 144, Supplement 1 (2024): 5350. https://doi.org/10.1182/blood-2024-210303.

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Introduction: Brazil is currently facing a dengue fever (DF) epidemic, with the highest number of cases and deaths ever reported in the city of São Paulo. Although DF is an increasing public health issue worldwide, there are few reports of clinical and laboratorial characteristics of this disease in patients with hematological diseases. Objective: to report the characteristics and outcomes of DF in 34 adult patients followed at a Hematology Day Hospital facility in Brazil. Methods: Retrospective, observational study conducted at the Instituto Central do Hospital das Clínicas, Faculdade de Medi

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Sorokin, M., N. Lutova, and V. Wied. "Phenomenology of psychiatric stigma: A factor of patients’ motivation to treatment." European Psychiatry 64, S1 (2021): S502. http://dx.doi.org/10.1192/j.eurpsy.2021.1344.

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IntroductionPsychiatric patients often are self-stigmatized and hardly involve in the treatment.ObjectivesAssociations of self-stigmatizing beliefs in psychiatric inpatients and their treatment motivation.Methods63 inpatients; ICD-10: F2–65%, F3–13%, F4+F6–14%, F06–8%; mean age 34±13, illness duration 12±11 years. Treatment Motivation Assessment Questionnaire (TMAQ), Internalized Stigma of Mental Illness scale (ISMI); K-mean cluster analysis; dispersion analyses; p≤0.05.Results18 patients of cluster 1 (C1) demonstrated explicit self-stigmatization. In comparison with 25 subjects from cluster 3

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O’Brien, Susan, Gary Schiller, Robert Kenneth Stuart, Diana Hudak, and Francis Giles. "Survival after Complete Response to Treatment with Laromustine (CLORETAZINE®) in Elderly Patients with De Novo Poor Risk Acute Myelogenous Leukemia (AML)." Blood 112, no. 11 (2008): 940. http://dx.doi.org/10.1182/blood.v112.11.940.940.

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Abstract Background: Treatment options for patients with AML are limited. Poor outcomes are associated with increasing age, decreasing performance status, unfavorable cytogenetics, and the presence of comorbid conditions. Elderly patients ³ 65 years with AML have a short survival (median 2.4 months) (Lang 2005), and for older patients who receive treatment, 1-year survival is 5–25% (Menzin 2002, Kantarjian 2006, Burnett 2007). CR/CRp is a desired outcome from induction treatment and a requisite for meaningful survival. Laromustine (Cloretazine) is a novel sulfonylhydrazine alkylating agent whi

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Regan, Samuel, Michael Dykstra, Huiying Yin, et al. "Contemporary post-prostatectomy radiation therapy for prostate cancer within a statewide quality consortium." Journal of Clinical Oncology 43, no. 5_suppl (2025): 369. https://doi.org/10.1200/jco.2025.43.5_suppl.369.

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369 Background: The 2024 AUA Salvage Therapy for Prostate Cancer Guideline provides guidance at the time of suspected recurrence after radical prostatectomy (RP). Recommendations include early initiation of post-operative radiation therapy (RT), and the addition of androgen deprivation therapy (ADT) for those with high-risk features. Given that an increasing number of men receive RP for high-risk disease, we characterized RT in a prospective cohort from the Michigan Radiation Oncology Quality Consortium (MROQC) and the Michigan Urological Surgery Improvement Collaborative (MUSIC). Methods: Pat

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Carey, Patricia, Animesh D. Pardanani, Patrick Starlinger, Ayalew Tefferi, and Naseema Gangat. "Outcome of Splenectomy in JAK2 Inhibitor Treated Patients with Myelofibrosis: A Mayo Clinic Experience in 34 Consecutive Cases." Blood 144, Supplement 1 (2024): 6662. https://doi.org/10.1182/blood-2024-199246.

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Background: Treatment of symptomatic splenomegaly in myelofibrosis (MF) was revolutionized by JAK2 inhibitors (JAKi), with ruxolitinib inducing a &gt;35% spleen volume reduction in 42% of patients at 24 weeks (N Engl J Med 2012;366). However, the benefit is often transient with a median duration of spleen response of three years (N Engl J Med. 2011;365). Treatment modalities for the management of MF-associated splenomegaly resistant to JAKi treatment includes surgical resection and involved-field radiotherapy. In the current study, we describe our experience with the former. Methods: Study

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Katayama, M., and R. M. Roberts. "105 THE Oct4/Cdx2 EXPRESSION AND CELL FATE OF INDIVIDUAL TWO-CELL BLASTOMERES IN TWO MOUSE STRAINS." Reproduction, Fertility and Development 20, no. 1 (2008): 133. http://dx.doi.org/10.1071/rdv20n1ab105.

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Fertile adults and occasionally twins have been derived from murine blastomeres at the 2-cell stage, indicating that such blastomeres may be equivalently totipotent, but there are conflicting reports that individual blastomeres from 2-cell stage murine conceptuses make different contributions to the embryonic and abembryonic regions of the blastocyst, implying that they differ in developmental potential. Here, we have re-examined this subject using 2 mouse strains, CF1 and NIH Swiss (SW), and 2 experimental approaches, random blastomere destruction at the 2-cell stage by repeated insertion of

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Sorror, Mohamed L., Barry Storer, Brenda M. Sandmaier, et al. "Allogeneic Hematopoietic Cell Transplantation (HCT) after Nonmyeloablative Conditioning for Patients (pts) Aged ≥60 Years." Blood 112, no. 11 (2008): 2162. http://dx.doi.org/10.1182/blood.v112.11.2162.2162.

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Abstract Median ages of pts with most hematological malignancies are beyond 60 years. The advent of nonmyeloablative conditioning regimens has extended the use of allogeneic HCT to these older pts. Here, we retrospectively investigated outcomes among 280 pts aged ≥60 years, given HCT between 1998 and 2006. Results were broken down in 3 age groups 60–64 (n=166), 65–69 (n=90), and ≥70 (n=24) years old, respectively. Pts aged ≥70 years had less preceding chemotherapy, less often failed autologous HCT, more often had related grafts, and had higher comorbidity scores compared to pts in the other tw

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Baz, Rachid, Thomas G. Martin, Melissa Alsina, et al. "Pomalidomide, Cyclophosphamide, and Dexamethasone Is Superior to Pomalidomide and Dexamethasone in Relapsed and Refractory Myeloma: Results of a Multicenter Randomized Phase II Study." Blood 124, no. 21 (2014): 303. http://dx.doi.org/10.1182/blood.v124.21.303.303.

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Abstract Background: Pomalidomide-dexamethasone results in an overall response rate of 33% and median PFS of 4.2 months in patients with prior lenalidomide and bortezomib (Richardson et al. Blood 2014). In this randomized phase II trial, we compared pomalidomide-dexamethasone (arm B) versus the addition of oral weekly cyclophosphamide to pomalidomide-dexamethasone (arm C) in patients with lenalidomide-refractory multiple myeloma (MM). We have previously reported that the recommended phase II dose of cyclophosphamide with standard-dose pomalidomide + dexamethasone was 400 mg PO D1, 8, 15. Patie

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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. III 2/4-Nitrophenoxides of Univalent Heavy Metals." Australian Journal of Chemistry 51, no. 8 (1998): 735. http://dx.doi.org/10.1071/c97100.

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Room-temperature single-crystal X-ray studies are recorded for 2- and 4-nitrophenoxide salts of silver(I) and thallium(I), M(2-np) and Tl(4-np) (anhydrous), and Ag(4-np).H2O. Ag(2-np) is monoclinic, P21/c, a 9·012(4), b 5·743(5), c 12·594(5) Å, β 104·34(4)°, Z = 4; conventional R on |F| was 0·042 for No 1378 independent ‘observed’ (I > 3σ(I)) reflections. Tl(2-np) is monoclinic, C2/c, a 27·250(3), b 3·712(1), c 15·147(3) Å, β 114·41(1)°, Z = 8, R 0·025 for No 1346. Ag(4-np).H2O is monoclinic, P21/a, a 5·613(6), b 13·191(7), c 9·844(5) Å, β 92·50(6)°, Z = 4, R 0 ·033 for No 622. Tl(4-np) is

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Begna, Kebede H., Naseema Gangat, Mithun V. Shah, et al. "Anthracycline Choices for Induction Chemotherapy Among 797 Consecutive Adult Patients with Acute Myeloid Leukemia: Daunorubicin-60 Vs Idarubicin-12 Vs Daunorubicin-90." Blood 138, Supplement 1 (2021): 1267. http://dx.doi.org/10.1182/blood-2021-147485.

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Abstract Objective : We describe the Mayo Clinic experience in 797 newly-diagnosed patients with acute myeloid leukemia (AML) serially treated with 7+3 induction chemotherapy that included 3 days of daunorubicin at a daily dose of 60 mg/m2 (dauno-60; n=239) or 90 mg/m2 (dauno-90; n=52), or idarubicin 12 mg/m2 (IDA-12; n=506). Our objective was to compare overall (OS) and relapse-free (RFS) survival outcome. Methods : Newly-diagnosed AML patients seen at our institution and received intensive induction chemotherapy were identified from the Mayo Clinic AML database. Treatment period spanned from

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James, David V. B., Linda J. Reynolds, and Sara Maldonado-Martin. "Influence of the Duration of a Treadmill Walking Bout on Heart Rate Variability at Rest in Physically Active Women." Journal of Physical Activity and Health 7, no. 1 (2010): 95–101. http://dx.doi.org/10.1123/jpah.7.1.95.

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Background:Heart rate variability (HRV) has been promoted as a noninvasive method of evaluating autonomic influence on cardiac rhythm. Although female subjects predominate in the walking studies, no study to date has examined the influence of the duration of a moderate intensity walking physical activity bout on HRV in this population.Methods:Twelve healthy physically active middle-aged women undertook 2 conditions; 20min (W20) and 60min (W60) bouts of walking on a treadmill. Resting HRV measures were obtained before (−1 h), and 1 h and 24 h after the walking bouts.Results:Mean NN interval (ie

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Al-Batran, Salah-Eddin, Joerg Thomas Hartmann, Stephan Probst, et al. "Phase III Trial in Metastatic Gastroesophageal Adenocarcinoma with Fluorouracil, Leucovorin Plus Either Oxaliplatin or Cisplatin: A Study of the Arbeitsgemeinschaft Internistische Onkologie." Journal of Clinical Oncology 26, no. 9 (2008): 1435–42. http://dx.doi.org/10.1200/jco.2007.13.9378.

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Purpose This study was designed to compare fluorouracil, leucovorin, and oxaliplatin with fluorouracil, leucovorin, and cisplatin in patients with advanced gastric cancer. Patients and Methods Patients with previously untreated advanced adenocarcinoma of the stomach or esophagogastric junction were randomly assigned to receive either fluorouracil 2,600 mg/m2 via 24-hour infusion, leucovorin 200 mg/m2, and oxaliplatin 85 mg/m2 (FLO) every 2 weeks or fluorouracil 2,000 mg/m2 via 24-hour infusion, leucovorin 200 mg/m2 weekly, and cisplatin 50 mg/m2 every 2 weeks (FLP). The primary end point was p

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Pekov, Igor V., Natalia V. Zubkova, Atali A. Agakhanov, et al. "New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. VIII. Arsenowagnerite, Mg2(AsO4)F." Mineralogical Magazine 82, no. 4 (2018): 877–88. http://dx.doi.org/10.1180/minmag.2017.081.067.

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ABSTRACTA new mineral arsenowagnerite, Mg2(AsO4)F, the arsenate analogue of wagnerite, was found in sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated closely with johillerite, tilasite, anhydrite, hematite, fluorophlogopite, cassiterite, calciojohillerite, aphthitalite and fluoborite. Arsenowagnerite occurs as equant to tabular crystals up to 1 mm across combined in interrupted crusts up to 0.1 cm × 1.5 cm × 3 cm. The mineral is transparent, light yellow,

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Xiang, L., A. Low, Y. Y. Leung, et al. "POS1413 INTERVAL BETWEEN SYMPTOM ONSET AND DIAGNOSIS AMONG PATIENTS WITH AUTOIMMUNE RHEUMATIC DISEASES IN A MULTI-ETHNIC ASIAN POPULATION." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 990.1–990. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1713.

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Background:The interval between symptom onset and diagnosis can often be longer than is ideal in autoimmune rheumatic diseases (ARDs).Objectives:We aimed to characterise this interval among patients newly diagnosed with ARDs in a multi-ethnic Asian population and to identify factors associated with a longer interval.Methods:We used Scott’s model of pathways to treatment to characterise the interval between symptom onset and diagnosis into 4 intervals: #1 between symptom onset and first seeking medical attention, #2 between first medical attention and rheumatology referral, #3 between rheumatol

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Hollmig, K. A., J. M. Stover, M. C. Fox, et al. "Collection of Peripheral Blood Stem Cells in 668 Patients with Multiple Myeloma Treated on Total Therapy II (UARK 98-026)." Blood 104, no. 11 (2004): 5236. http://dx.doi.org/10.1182/blood.v104.11.5236.5236.

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Abstract Total Therapy II (TT2), consisting of intensive induction with non-cross resistant VAD, DCEP, CAD (with collection of PBSC) and DCEP.; followed by tandem autotransplants in support of melphalan 200mg/m2; followed by consolidation chemotherapy every 3 months x4 ; followed by interferon maintenance, has complete accrual of 668 patients with upfront randomization to +/− Thalidomide. Collection goal was 20 million CD34+ cells/kg with CAD. This number allows for tandem transplants with support of >5 x 106 CD34 cells/kg, additional cells were stored in case of engraftment problems, addit

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McMahon, Colin J., Karim Ayoubi, Rania Mehanna, et al. "Outcome of congenital tracheal stenosis in children over two decades in a national cardiothoracic surgical unit." Cardiology in the Young 30, no. 1 (2019): 34–38. http://dx.doi.org/10.1017/s1047951119002725.

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AbstractObjective:To assess the outcomes of congenital tracheal stenosis among children.Materials and methods:A retrospective review of all children who underwent surgical repair of congenital tracheal stenosis reviewing charts, operative notes, echocardiograms, CT and MRI data from January 2002 to February 2019.Results:Twenty-six children underwent surgical treatment for tracheal stenosis. The median age was 3 months (range 0.3–35 months) and the median weight was 4.7 kg (range 2.5–13 kg) at the time of surgical intervention. Stridor was the most common presenting symptom in 17 patients (65%

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Robles, Margot, Loic Ysebaert, Stephane Vigouroux, et al. "Improved Outcome After Allogeneic Stem-Cell Transplantation (SCT) As Compared to Non-Allogeneic SCT Therapies in Patients with High-Risk Peripheral T-Cell Lymphomas in First Response." Blood 120, no. 21 (2012): 3111. http://dx.doi.org/10.1182/blood.v120.21.3111.3111.

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Abstract Abstract 3111 Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of rare malignancies usually occurring in middle-aged to elderly patients (pts), with an advanced disease and unfavorable international prognostic index (IPI) scores. Excluding ALK-positive anaplastic large cell lymphomas (ALCL) and indolent mycosis fungoides, they are often characterized by a poor prognosis. There is no consensus about optimal therapy and the role of allogeneic stem-cell transplantation (allo-SCT) as first line therapy remains to be investigated. In an effort to explore this therapeutic option

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Radin, M., I. Cecchi, S. G. Foddai, et al. "FRI0589 CLINICAL ACCURACY OF ANTI-PHOSPHATIDYLSERINE/PROTHROMBIN AND ANTI-BETA2GLYCOPROTEIN I DOMAIN I FOR PREDICTING CLINICAL MANIFESTATIONS OF ANTIPHOSPHOLIPID SYNDROME." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 899.1–900. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2330.

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Background:Antiphospholipid antibody (aPL) specificities are increasing, however the best accuracy for predicting the clinical manifestations of the diseases is still under debate.Objectives:To evaluate the clinical accuracy of aPL specificities both individually and/or in combination, to identify a panel of tests that may provide the best accuracy for predicting clinical manifestations of antiphospholipid syndrome (APS).Methods:We chart-reviewed patients that presented at San Giovanni Bosco Hospital in the last 5 years who tested persistently positive for at least one aPL[1]. Inclusion criter

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Hafeez, Muhammad Usman, Farhat Fatima, Syeda Tehmina Bukhari, et al. "A Synergistic Imperative: An Integrated Policy and Education Framework for Navigating the Climate Nexus." Inverge Journal of Social Sciences 4, no. 2 (2025): 118–24. https://doi.org/10.63544/ijss.v4i2.135.

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Climate change acts as a systemic multiplier of threats, exacerbating interconnected global crises that jeopardize food security, biodiversity, and environmental health. These challenges are compounded by socioeconomic inequalities and governance gaps, with vulnerable populations disproportionately bearing the consequences of rising temperatures, extreme weather events, and ecosystem degradation. While climate policy and environmental education have been extensively researched as separate disciplines, the critical intersection where these two fields must converge to function synergistically, b

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Desmedt, Christine, Signe Borgquist, Laura Garcia-Estevez, et al. "Impact of body mass index (BMI) on efficacy and safety of abemaciclib in breast cancer patients (pts) treated in the monarchE trial." Journal of Clinical Oncology 43, no. 16_suppl (2025): 520. https://doi.org/10.1200/jco.2025.43.16_suppl.520.

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520 Background: Two years (yrs) of adjuvant abemaciclib + endocrine therapy (ET) resulted in sustained improvement in invasive disease-free survival (IDFS HR=0.68, 5 yrs rates: 84% abemaciclib + ET vs 76% ET, 8% absolute benefit) in pts with hormone receptor positive, human epidermal growth factor receptor 2 negative, node-positive, high-risk early breast cancer (EBC). Obesity is an established factor influencing the biology and prognosis of breast cancer; however, the specific impact on treatment (tx) outcomes remains uncertain. Here we report efficacy and safety by BMI in monarchE. Methods:

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Otto, Rafael, Paulo Cesar Ocheuze Trivelin, Henrique Coutinho Junqueira Franco, Carlos Eduardo Faroni, and André Cesar Vitti. "Root system distribution of sugar cane as related to nitrogen fertilization, evaluated by two methods: monolith and probes." Revista Brasileira de Ciência do Solo 33, no. 3 (2009): 601–11. http://dx.doi.org/10.1590/s0100-06832009000300013.

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Few studies on sugar cane have evaluated the root system of the crop, in spite of its importance. This is mainly due to the difficulty of evaluation and high variability of results. The objective of this study was to develop an evaluation method of the cane root system by means of probes so as to evaluate the mass, distribution and metabolically active roots related to N fertilization at planting. For this purpose, an experiment was conducted in an Arenic Kandiustults with medium texture in Jaboticabal/SP, in a randomized block design with four replications and four treatments: control (withou

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Miyashita, Masashi, and Kumpei Tokuyama. "Moderate exercise reduces serum triacylglycerol concentrations but does not affect pre-heparin lipoprotein lipase concentrations after a moderate-fat meal in young men." British Journal of Nutrition 99, no. 5 (2008): 1076–82. http://dx.doi.org/10.1017/s0007114507853438.

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Aerobic exercise has been shown to lower postprandial TAG concentrations after a meal(s) of high-fat content. This study examined the effects of moderate-intensity cycling on postprandial TAG concentrations and pre-heparin lipoprotein lipase concentrations after subjects consumed a meal of moderate-fat content (45 % of total energy). Twelve male subjects, aged 24 (sem 1) years, completed two 2 d trials (exercise and control) at least 1 week apart in a randomised, repeated measures design. On day 1, subjects either cycled for 30 min at 65 % of maximum heart rate in the afternoon or rested (no e

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Wenzel, Mike, Florestan Koll, Benedikt Hoeh, et al. "Real-world comparison of cabazitaxel vs. 177-lutetium-PSMA radioligand therapy in metastatic castration resistant prostate cancer." Journal of Clinical Oncology 43, no. 5_suppl (2025): 70. https://doi.org/10.1200/jco.2025.43.5_suppl.70.

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70 Background: 177-Lutetium Prostate-specific membrane antigen (Lu-PSMA) therapy is under current scientific investigation and aims to become an established part in treatment of metastatic castration resistant prostate cancer (mCRPC). However, real-world evidence in treatment comparison is scant. Methods: We relied on the FRAMCAP database and compared cabazitaxel vs. Lu-PSMA therapy in mCRPC patients regarding progression-free (PFS) and overall (OS). Sensitivity analyses addressed 2 nd to 4 th line mCRPC patients to approximate current Phase-III patient selection criteria. Results: Of 373 mCRP

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Quintas-Cardama, Alfonso, Hagop Kantarjian, Guillermo Garcia-Manero, et al. "Early Clearance of Peripheral Blood Blasts but Not White Blood Cells Is a Powerful Prognostic marker for complete Response and Overall Survival in Patients with Acute Myeloid Leukemia (AML) receiving Induction Chemotherapy." Blood 118, no. 21 (2011): 1553. http://dx.doi.org/10.1182/blood.v118.21.1553.1553.

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Abstract Abstract 1553 Background: Most pts with AML will achieve complete remission (CR) following therapy with cytarabine and an anthracycline. Early clearance of blasts in peripheral blood (PB) has been shown to be an important prognostic factor in acute lymphoblastic leukemia. We explored the dynamics of PB blasts in pts with AML undergoing induction chemotherapy with AI (ara-C 1.5g/m2x3d and idarubicin 12mg/m2x3d) at our institution and their impact in long-term outcomes. Patients & Methods: We reviewed the dynamics of PB blasts (i.e. PB blasts=0%) or WBC (i.e. WBC≤0.1×109/dL) clearan

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Sawalha, Yazeed, Shayna R. Sarosiek, Rina Li Welkie, et al. "Outcomes of Patients with Relapsed/Refractory Lymphoplasmacytic Lymphoma Treated with Venetoclax: A Multicenter Retrospective Analysis." Blood 142, Supplement 1 (2023): 3045. http://dx.doi.org/10.1182/blood-2023-187237.

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Background: Data on the clinical activity of venetoclax (ven) in lymphoplasmacytic lymphoma (LPL) are primarily limited to a phase 2 trial of ven monotherapy for a 2-year duration in 32 patients (pts) with relapsed/refractory IgM LPL who received a median of 2 prior treatments (tx), including 16 pts with prior BTK inhibitors (BTKi) (Castillo et al, JCO 2021). Overall response rate (ORR) was 84% and median progression-free survival (PFS) was 30 months (mos). We report the clinical activity of ven and prognostic factors associated with outcomes in a larger cohort. Methods: We included pts with L

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Pieczka, A., R. J. Evans, E. S. Grew, L. A. Groat, ,. C. Ma, and G. R. Rossman. "The dumortierite supergroup. II. Three new minerals from the Szklary pegmatite, SW Poland: Nioboholtite, (Nb0.6□0.4)Al6BSi3O18, titanoholtite, (Ti0.75□0.25)Al6BSi3O18, and szklaryite, □Al6BAs3+3O15." Mineralogical Magazine 77, no. 6 (2013): 2841–56. http://dx.doi.org/10.1180/minmag.2013.077.6.10.

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AbstractThree new minerals in the dumortierite supergroup were discovered in the Szklary pegmatite, Lower Silesia, Poland. Nioboholtite, endmember (Nb0.6☐0.4)Al6B3Si3O18, and titanoholtite, endmember (Ti0.75☐0.25)Al6B3Si3O18, are new members of the holtite group, whereas szklaryite, endmember ☐Al6BAs3+3O15, is the first representative of a potential new group. Nioboholtite occurs mostly as overgrowths not exceeding 10 μm in thickness on cores of holtite. Titanoholtite forms patches up to 10 μm across in the holtite cores and streaks up to 5 μm wide along boundaries between holtite cores and th

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Chaparro, M., A. Garre, F. Mesonero, et al. "OP29 Tofacitinib in ulcerative colitis: Real-world evidence from Eneida Registry." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S026—S028. http://dx.doi.org/10.1093/ecco-jcc/jjz203.028.

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Abstract Background Our aim was to evaluate the effectiveness and safety of tofacitinib in ulcerative colitis (UC) in real life. Methods Patients from the prospectively maintained ENEIDA registry treated with tofacitinib due to active UC were included. Clinical activity and effectiveness were defined based on Partial Mayo Score (PMS). The short-term response was assessed at week 4, 8 and 16. The last-observation-carried-forward method was used in patients that stopped tofacitinib before the time-points for clinical assessment. Variables associated with short-term remission at week 8 were ident

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Komrokji, Rami S., Guillermo Garcia-Manero, Lionel Ades, et al. "An Open-Label, Phase 2, Dose-Finding Study of Sotatercept (ACE-011) in Patients with Low or Intermediate-1 (Int-1)-Risk Myelodysplastic Syndromes (MDS) or Non-Proliferative Chronic Myelomonocytic Leukemia (CMML) and Anemia Requiring Transfusion." Blood 124, no. 21 (2014): 3251. http://dx.doi.org/10.1182/blood.v124.21.3251.3251.

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Abstract Introduction: Anemia, a hallmark of MDS, is challenging to treat, particularly after failure of erythropoiesis-stimulating agents (ESAs). Sotatercept (ACE-011) is a novel and first-in-class activin type IIA receptor fusion protein that acts on late-stage erythropoiesis to increase mature erythrocyte release into the circulation (Carrancio et al. Br J Haematol 2014;165:870-82). Treatment with sotatercept stimulated erythropoiesis and significantly increased hemoglobin (Hb) levels in healthy volunteers (Sherman et al. J Clin Pharmacol 2013;53:1121-30), supporting its clinical developmen

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Wenzel, Mike, Florestan Koll, Benedikt Hoeh, et al. "Cancer-control outcomes of metastatic castration resistant prostate cancer patients with BRCA -gene or tumor suppressor mutations undergoing 177-lutetium PSMA radioligand therapy." Journal of Clinical Oncology 43, no. 5_suppl (2025): 71. https://doi.org/10.1200/jco.2025.43.5_suppl.71.

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71 Background: Several tumor gene mutations are known for metastatic castration-resistant prostate cancer (mCRPC) are known. The individual response to 177-Lutetium Prostate-specific membrane antigen (Lu-PSMA) therapy is under current investigation regarding the genomic profile of mCRPC patients. Methods: We relied on the FRAMCAP database and compared progression-free (PFS) and overall survival (OS) rates of mCRPC patients with Breast Cancer related antigen ( BRCA ) or tumor suppressor gene mutations ( TP53, PTEN, RB1 [TSG]). Especially, subgroup analyses were performed for Lu-PSMA-treated mCR

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Puche Larrubia, M. Á., M. L. Ladehesa Pineda, F. U. Pilar, A. Moltó, C. López-Medina, and E. Collantes-Estevez. "POS0946 DISTRIBUTION OF COMORBIDITIES IN SPONDYLOARTHRITIS WITH REGARD TO THE PHENOTYPE AND THE PRESENCE OF PSORIASIS: DATA FROM THE ASAS-COMOSPA STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 736.1–736. http://dx.doi.org/10.1136/annrheumdis-2021-eular.306.

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Background:Comorbidities have been reported to be more prevalent in patients with Spondyloarthritis (SpA) compared to the general population. Previous studies have suggested that patients with peripheral phenotypes exhibit a higher prevalence of traditional cardiovascular risk (CV) factors compared to those with a predominantly axial phenotype. However, the role of psoriasis in such differences has not been deeply studied.Objectives:To compare the prevalence of comorbidities (CV, malignancies and osteoporosis (vertebral or peripheral fracture, or low bone mineral density)) between patients wit

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Hui, Edwin P., Brigette B. Ma, Sing F. Leung, et al. "Randomized Phase II Trial of Concurrent Cisplatin-Radiotherapy With or Without Neoadjuvant Docetaxel and Cisplatin in Advanced Nasopharyngeal Carcinoma." Journal of Clinical Oncology 27, no. 2 (2009): 242–49. http://dx.doi.org/10.1200/jco.2008.18.1545.

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Purpose To compare the toxicities, tumor control, survival, and quality of life of nasopharyngeal cancer (NPC) patients treated with sequential neoadjuvant chemotherapy followed by concurrent cisplatin-radiotherapy (CRT) or CRT alone. Patients and Methods Previously untreated stage III to IVB NPC were randomly assigned to (1) neoadjuvant docetaxel 75 mg/m2 and cisplatin 75 mg/m2 every 3 weeks for two cycles, followed by cisplatin 40 mg/m2/wk concurrent with radiotherapy, or (2) CRT alone. Planned accrual was 30 patients per arm to detect 20% difference of toxicities based on 95% CIs. Results F

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