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Journal articles on the topic '658.8 : 339.166.5'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Dale, David C., Steven P. Treon, David F. McDermott, et al. "Oral Administration of Mavorixafor, a CXCR4 Antagonist, Increases Peripheral White Blood Cell Counts across Different Disease States." Blood 138, Supplement 1 (2021): 2186. http://dx.doi.org/10.1182/blood-2021-152990.

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Abstract Introduction: Peripheral leukocyte deficiency is a common feature of multiple diseases and may render affected individuals susceptible to infections, both common and opportunistic. The CXCR4 chemokine receptor regulates the trafficking of leukocytes among the bone marrow, blood, and lymphatic system (Al Ustwani O, et al. Br J Haematol. 2014;164:15-23). Mavorixafor is an orally available investigational, small-molecule, selective antagonist of the CXCR4 receptor with potential to restore physiological trafficking and maturation of white blood cells (WBCs). Mavorixafor was previously sh

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Žorža, Laura, Aija Dēliņa, Tūrs Selga, and Olga Muter. "Characterization of Biofilm Formation and Bacterial Resistance to Benzalkonium Chloride under Contrasting Cultivation Conditions." Fermentation 9, no. 8 (2023): 699. http://dx.doi.org/10.3390/fermentation9080699.

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Benzalkonium chloride (BAC) is one of the most commonly used quaternary ammonium compounds in the pharmaceutical, cosmetic, and food industries. The aim of our study was to compare the physiological responses of Escherichia coli MSCL 332, Pseudomonas putida MCCL 650, and Staphylococcus epidermidis MSCL 333 on 50 mg/L BAC in rich and poor medium (100% and 5% tryptone soya broth (TSB)) in the temperature range from 8 °C to 37 °C, under static and shaking conditions. A high-throughput, 96-well microplate method was used to compare a broad range of cultivation conditions. The effect of BAC on grow

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Kang, Elizabeth M., Ellen M. Areman, Virginia David-Ocampo, et al. "Mobilization, collection, and processing of peripheral blood stem cells in individuals with sickle cell trait." Blood 99, no. 3 (2002): 850–55. http://dx.doi.org/10.1182/blood.v99.3.850.

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Abstract Mobilized peripheral blood is increasingly used as the source of hematopoietic stem cells for allogeneic transplantation, currently the only curative approach for sickle cell anemia. However, the safety and feasibility of stem cell mobilization in individuals with sickle cell trait (SCT) has not been documented. This study is a prospective controlled trial to evaluate the safety and feasibility of peripheral blood stem cell (PBSC) mobilization in 8 SCT subjects and 8 control subjects matched for age and race. Mobilization with filgrastim 10 μg/kg subcutaneous daily for 5 days was foll

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Khadidja KERZABI-KANOUN, Nabila BELYAGOUBI-BENHAMMOU, Larbi BELYAGOUBI, et al. "Antioxidant Activity of Brown Seaweed (Padina pavonica (L.) Extracts From the Algerian Mediterranean Coast." Journal of Natural Product Research and Applications 1, no. 02 (2021): 54–62. http://dx.doi.org/10.46325/jnpra.v1i02.15.

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The crude methanolic extract, ethyl acetate and butanolic fractions, tannins, saponins and polysaccharides of the marine brown alga, Padina pavonica, growing on the Algerian Mediterranean Coast were measured for antioxidant activity, using total antioxidant capacity (TAC), reducing power and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assays. Total phenolic, flavonoid and proanthocyanidin contents were determined. The total phenolic, proanthocyanidin and flavonoid contents of methanolic extract were about of 2.007 ± 0.104 mg GAE/g DM, 4.611 ± 0.346 mg CE/g DM and 1.132 ± 0.091 mg C

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Lazo-Langner, Alejandro, Jeff Hawell, Michael J. Kovacs, et al. "A Systematic Review and Meta-Analysis of Proportions of Thrombosis and Bleeding in Patients Receiving Venous Thromboembolism (VTE) Prophylaxis After Orthopedic Surgery (OS). An Update." Blood 114, no. 22 (2009): 3125. http://dx.doi.org/10.1182/blood.v114.22.3125.3125.

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Abstract Abstract 3125 Poster Board III-62 VTE is the most frequent complication of OS and it can be prevented through anticoagulant prophylaxis. Numerous studies have evaluated different agents for this purpose and there are new agents currently under development or recently approved for this indication. We conducted a systematic review of randomized controlled trials (RCT) evaluating administration of anticoagulants for VTE prophylaxis in OS and performed a MA of proportions to estimate the overall incidence of major VTE (proximal VTE, pulmonary embolism (PE), or death from PE), total VTE (p

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Varghese, Abraham Mullasseril, Lauren Wright, Talha Munir, Russell Patmore, Catherine Parbutt, and Alexandra Smith. "Population-Based Registry Data over 15 Years Suggests Comparable Overall Survival for CLL Patients Treated with Chemoimmunotherapy and Targeted Therapies As First-Line Treatments." Blood 144, Supplement 1 (2024): 5122. https://doi.org/10.1182/blood-2024-201655.

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Phase 3 clinical trials have shown that targeted therapies (TT), significantly improve progression-free survival (PFS) compared to chemoimmunotherapy (CIT) for patients with chronic lymphocytic leukemia (CLL) with very few demonstrating a difference in overall survival (OS). TT are now the preferred first-line treatment for CLL patients across all age groups. Nevertheless, evidence demonstrating differences in OS in real-world settings remains scarce. This study aims to evaluate OS in patients who began treatment with either chemotherapy (CT) or CIT compared to those who received TT as their f

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Gomes, Tiago Halyson de Oliveira, Welleson Feitosa Gazel, Emanuela Ferreira Goulart, Jennifer Lee Gonçalves, Gabriel Vargas Maia Chaves, and Lígia Luana Freire da Silva. "ÓBITOS DEVIDOS À SEPSE ESTREPTOCÓCICA NO BRASIL: ANÁLISE DE 13 ANOS." Revista ft 29, no. 143 (2025): 45–46. https://doi.org/10.69849/revistaft/ch10202502210945.

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Introdução: A sepse é uma síndrome caracterizada por uma resposta inflamatória exacerbada a uma infecção, levando à disfunção orgânica e risco elevado de morte. Fatores de risco como o uso de cateteres, sonda uretral, imunossupressão, comorbidades, infecções pré-existentes, resistência antimicrobiana e estado nutricional comprometido são determinantes importantes para o desenvolvimento da doença. Objetivos: O objetivo do presente trabalho é realizar o levantamento epidemiológico acerca dos óbitos por casos de septicemia estreptocócica no Brasil, em um período de 13 anos. Bem como realizar o le

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Maseeh, Arun, Bhawana Awasthy, and Somrita Modak. "Anticancer–drug-induced interstitial lung disease (DIILD): With great power comes great responsibility." Journal of Clinical Oncology 41, no. 16_suppl (2023): e18699-e18699. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e18699.

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e18699 Background: DIILD accounts for 3-5% of all ILD cases, with Anticancer agents accounting for 23-51% of all cases, and Case-Fatality Rates of 51.3%. Guidelines for anticancer therapy-related DIILD are lacking. DIILD was not often identified as an adverse event until late in drug development or after launch. Methods: Publications till Feb 2023 were reviewed for incidence, time to onset, prevention and early identification of anticancer DIILD. Results: Highest reportedincidence of DIILD was associated with targeted therapies [mTOR Inhibitors (9.5- 58%), Anti-EGFR (0.9 - 5.9%), MEK inhibitor

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Gordon, Kenneth, Diamant Thaçi, Melinda Gooderham, et al. "Bimekizumab Safety and Tolerability in Moderate to Severe Plaque Psoriasis: Pooled Analysis from Up to 4 Years of Treatment in 5 Phase 3/3b Clinical Trials." SKIN The Journal of Cutaneous Medicine 8, no. 4 (2024): s404. http://dx.doi.org/10.25251/skin.8.supp.404.

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Introduction: Psoriasis is a chronic condition requiring long-term management; evaluating long-term safety of treatments is important. We report the first 4-year (yr) safety data for bimekizumab (BKZ) in patients with moderate to severe plaque psoriasis. Methods: Data were pooled from 5 trials: BE SURE/BE VIVID/BE READY, their open-label extension (OLE) BE BRIGHT (4‑yr data; cut-off 14Nov2022), and BE RADIANT (3‑yr data; cut‑off 6May2022).1-5 Patients received BKZ 320mg every 4 weeks (wks)(Q4W) or Q8W; all received Q8W from Wk64 (BE RADIANT)/OLE Wk48 (BE BRIGHT) or next scheduled visit. Treatm

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Prieto-Peña, D., F. Genre, S. Remuzgo Martinez, et al. "AB0146 BAFF, APRIL y BAFFR: DIFFERENTIAL BIOMARKERS BETWEEN IgA VASCULITIS AND IgA NEPHROPATHY?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1203–4. http://dx.doi.org/10.1136/annrheumdis-2022-eular.425.

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BackgroundIgA vasculitis (IgAV) and IgA nephropathy (IgAN) are inflammatory conditions [1, 2], that share pathogenic mechanisms [1], in which B-lymphocytes are described as key cells implicated in these processes. BAFF, APRIL and BAFF-R are cytokines implicated in the development of B-lymphocytes [3, 4] and in autoimmune processes [5, 6]. In this regard, an influence of BAFF, APRIL and BAFFR polymorphisms was observed on several immune-mediated conditions, being BAFF GCTGT>A a shared insertion-deletion variant for inflammatory conditions [7, 8].ObjectivesTo determine whether BAFF, APRIL and

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Penz, Daniela, Elisabeth Waldmann, Monika Hackl, et al. "Colorectal Cancer and Precursor Lesion Prevalence in Adults Younger Than 50 Years Without Symptoms." JAMA Network Open 6, no. 12 (2023): e2334757. http://dx.doi.org/10.1001/jamanetworkopen.2023.34757.

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ImportanceIncidence of colorectal cancer (CRC) is increasing among younger adults. However, data on precursor lesions in patients who are asymptomatic, especially those aged younger than 50 years, are lacking.ObjectiveTo analyze the prevalence and number needed to screen (NNS) for adenomas, advanced adenomas, and serrated lesions, as well as the incidence of CRC in patients older than age 20 years.Design, Setting, and ParticipantsThis cohort study was conducted among 296 170 patients who received a screening colonoscopy within a national screening colonoscopy registry from 2012 to 2018 in Aust

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Kupeli, Nuriye, Georgia Chatzitheodorou, and Bridget Candy. "55 The impact of emotional disclosure as a form of therapeutic intervention on health-related outcomes and on the well-being of people with advanced disease: a systematic review." BMJ Supportive & Palliative Care 7, no. 3 (2017): A368.1—A368. http://dx.doi.org/10.1136/bmjspcare-2017-001407.55.

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IntroductionTherapeutic emotional disclosure has been associated with positive psychological, physiological and behavioural changes.1In the form of expressive writing it commonly involves writing about a traumatic experience for 15 min over 3–5 consecutive days.2There is evidence that expressive writing in people with cancer may reduce pain and improve energy levels, sleep and psychological symptoms.3It has not been established in a review whether these interventions benefit people with advanced disease.AimsTo critique and pool the evidence from randomised controlled trials (RCTs) and other co

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Bonig, Halvard, Annette Wundes, Kai-Hsin Chang, Sylvia Lucas, and Thalia Papayannopoulou. "Hematopoietic Stem/Progenitor Cells (HSPC) Mobilization Parameters in Patients Chronically Treated with the CD49d Blocking Antibody Natalizumab." Blood 110, no. 11 (2007): 177. http://dx.doi.org/10.1182/blood.v110.11.177.177.

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Abstract Blockade of CD49d-mediated lymphocyte trafficking has been used therapeutically for certain autoimmune diseases. In addition to effects on mature lymphocytes, in mice and monkeys CD49d blockade also mobilizes immature hematopoietic cells from bone marrow (BM), capable of complete long-term engraftment despite a partial BM seeding defect. The aim of these studies was to ascertain effects on the biology of HSPC mobilization of single or chronic CD49d blockade in Multiple Sclerosis (MS) patients receiving disease-modifying treatment with the anti-functional anti-CD49d antibody, Natalizum

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Ahmed, Safia K., Odion Binitie, Mark D. Krailo, et al. "Evaluation of local control strategies on patterns of treatment failure in patients with localized ewing sarcoma treated on AEWS1031: A report from the children’s oncology group." Journal of Clinical Oncology 41, no. 16_suppl (2023): 11529. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.11529.

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11529 Background: To evaluate clinical characteristics and patterns of treatment failure in patients with localized Ewing sarcoma (ES) treated on AEWS1031 according to local control (LC) strategies, tumor size, and tumor site. Methods: AEWS1031 was a phase 3 randomized trial comparing two interval compressed chemotherapy regimens. Patients who completed LC on AEWS1031 were analyzed. LC was with surgery alone (S), definitive radiation therapy (RT), or surgery plus radiation (S+RT), and determined by the treating investigator. Local failure (LF) and distant failure (DF) were defined as recurrenc

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Ye, B. D., H. J. Kim, D. I. Park, et al. "P0474 Five-Year Clinical Outcomes and Disease Course of Newly-Diagnosed Moderate-to-Severe Ulcerative Colitis: A Prospective Nationwide Multicentre MOSAIK Cohort Study in Korea." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i1001—i1003. https://doi.org/10.1093/ecco-jcc/jjae190.0648.

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Abstract Background While the incidence of moderate-to-severe ulcerative colitis (UC) is rising in Asia, comprehensive data on its long-term disease course in Asian populations remain scarce. Methods The MOSAIK (MOderate-to-Severe ulcerAtive colItis in Korea) study is a prospective, multicentre, hospital-based, inception cohort that enrolled 353 patients newly diagnosed with moderate-to-severe UC between August 2014 and February 2017.1 Clinical outcomes and predictors of a disabling disease course were evaluated over 5 years of follow-up. Results Among 353 patients, the median age at UC diagno

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de Lima, Luiz Rodrigo Augustemak, Diego Augusto Santos Silva, Kelly Samara da Silva, Andreia Pelegrini, Isabela de Carlos Back, and Edio Luiz Petroski. "Aerobic Fitness and Moderate to Vigorous Physical Activity in Children and Adolescents Living with HIV." Pediatric Exercise Science 29, no. 3 (2017): 377–87. http://dx.doi.org/10.1123/pes.2017-0036.

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Purpose:To examine aerobic fitness, total moderate to vigorous physical activity (MVPA) and also patterns in terms of MVPA between children and adolescents with human immunodeficiency virus (HIV) and controls, and to determine whether differences, if any, are associated with HIV, sex and highly active antiretroviral therapy (HAART).Method:A cross-sectional analysis was carried out with 130 children and adolescents, aged between 8 and 15 years, divided into two groups (HIV group= 65 patients, control group= 65 healthy participants). Total MVPA was measured by accelerometers and 5 and 10-min bou

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Son, Young, Edward Wu, Shawon Akanda, Katelyn Klimowich, Thomas Mueller, and Gordon Andrew Brown. "Descriptive analysis of patients on active surveillance escalating to treatment for localized prostate cancer." Journal of Clinical Oncology 42, no. 16_suppl (2024): e17092-e17092. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e17092.

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e17092 Background: It is predicted that 1 in 8 men will be diagnosed with prostate cancer and 1 in 41 men will die of prostate cancer, making it the second leading cause of death in men. However, not all diagnosis of prostate cancer is clinically significant and active surveillance (AS) can be an option. Although AS is an option, an estimated 50% of patients will progress to treatment within 5-10 years. In this study, we aim to characterize those patients that required escalation to treatment from AS. Methods: A multicenter retrospective review was performed of patients that were had biopsy pr

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Micallef, Ivana, Stephen M. Ansell, Francis Buadi, et al. "A Risk Adapted Approach Utilizing Plerixafor in Autologous Peripheral Blood Stem Cell Mobilization." Blood 114, no. 22 (2009): 3211. http://dx.doi.org/10.1182/blood.v114.22.3211.3211.

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Abstract Abstract 3211 Poster Board III-148 Although autologous stem cell transplantation (ASCT) has become standard of care for many patients with hematologic malignancies, many patients fail to collect a minimum number of CD34 + stem cells to support high dose chemotherapy and ASCT. Recently, plerixafor, a CXCR4 antagonist, was FDA approved for use in combination with G-CSF for autologous peripheral blood stem cell mobilization in patients with NHL or Multiple Myeloma. In February 2009, we commenced a risk adapted approach to the utilization of plerixafor. The study was restricted to patient

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Barreira, S. C., A. R. Cruz-Machado, A. L. Fernandes, et al. "AB1145 PRESCRIPTION PATTERNS AND DISEASE ACTIVITY IN PORTUGUESE WOMEN OF CHILDBEARING AGE WITH RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND JUVENILE IDIOPATHIC ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1862.1–1863. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1976.

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Background:Disease activity (DA) at conception is one of the main predictors of pregnancy outcomes in women of childbearing age (WoCBA) with rheumatic diseases. Teratogenicity and unawareness about pregnancy compatibility of some disease-modifying anti-rheumatic drugs might limit the choice of treatment in WoCBA.Objectives:To assess differences in prescription patterns between WoCBA with rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS) and juvenile idiopathic arthritis (JIA) and comparator groups, namely postmenopausal women (PMW) and age-matched men. Evaluate

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Kotchetkov, Rouslan, Esther Masih-Khan, Chia-Min Chu, et al. "Secondary Myelodysplastic Syndrome/Acute Myeloblastic Leukemia During Lenalidomide-Based Regimens in Relapsed and/or Refractory Multiple Myeloma Patients: Single Center Experience." Blood 120, no. 21 (2012): 1867. http://dx.doi.org/10.1182/blood.v120.21.1867.1867.

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Abstract Abstract 1867 Secondary myelodysplastic syndrome and acute myelogenous leukemia (2° MDS/AML) are well-known complications that can occur after alkylating agent therapy for multiple myeloma (MM) or other cancers. However, until recently, the survival of MM pts was relatively short, a feature which may have contributed to a relatively low reported incidence of this complication in MM. The introduction of novel agents has improved survival rates of MM pts; lenalidomide (len) + dexamethasone–currently approved for MM after one prior therapy– is one of the main regimens that has contribute

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Andiru, G. A., C. C. Pasian, and J. M. Frantz. "Quantifying Water and Nutrient Losses with Hose Irrigation." Journal of Environmental Horticulture 33, no. 1 (2015): 29–32. http://dx.doi.org/10.24266/0738-2898-33.1.29.

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The amount of water, nitrogen (N), phosphorous (P), and iron (Fe) lost from potted impatiens (Impatiens wallerana Hook. f.) plants fertilized with either controlled-release fertilizer (CRF) of varying longevities or a water-soluble fertilizer (WSF), with irrigation provided with a hose in all treatments, was quantified. The plants were grown in a sphagnum peat-based soilless substrate containing either CRF [Osmocote Plus 16-9-12 (16-3.9-10-0.46 N:P:K:Fe), 5 to 6 month and or 8-to 9 month longevities] incorporated (6.8 kg·m−3 or 11.5 lb·yd−3) throughout the substrate and compared with plants fe

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Strati, Paolo, Kari Chaffee, Sara Achenbach, et al. "Disease Progression and Complications Are the Main Cause of Death in Patients with Chronic Lymphocytic Leukemia (CLL) Independent of Age and Comorbidities at Diagnosis." Blood 126, no. 23 (2015): 5265. http://dx.doi.org/10.1182/blood.v126.23.5265.5265.

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Abstract Introduction. CLL primarily affects elderly individuals who frequently have comorbid health conditions. It is typically assumed non-CLL-related etiologies will be the ultimate cause of death for most CLL patients, particularly those with comorbid conditions at diagnosis. Methods. Between 9/2002 and 11/2014, 1174 patients with newly diagnosed CLL were enrolled in a prospective cohort study evaluating the natural history of CLL. Comorbidities were prospectively recorded at the time of diagnosis. Comorbidities arising during the course of disease were not considered for this analysis. St

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Storandt, Michael H., Urshila Durani, Daniela Stan, et al. "Abstract 1012: Financial hardship in breast cancer survivors." Cancer Research 82, no. 12_Supplement (2022): 1012. http://dx.doi.org/10.1158/1538-7445.am2022-1012.

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Abstract Background: Medical financial hardship, encompassing material, behavioral, and psychologic domains, is becoming an increasingly common consequence of illness in cancer patients. Identifying at-risk patients is the first step to develop proactive approaches to mitigate this problem. To try and address this need, Mayo Clinic Breast Disease Registry (MCBDR) is prospectively collecting data about financial concerns in addition to the usual sociodemographic and clinical information. Methods: We used data from Mayo Clinic Breast Disease Registry, a prospective cohort of consenting patients

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Duran, Ignacio, Pablo Maroto, Cristina Suárez, et al. "Analysis of overall survival (OS) based on early tumor shrinkage in the phase III METEOR study of cabozantinib (cabo) versus everolimus (eve) in advanced renal cell carcinoma (RCC)." Journal of Clinical Oncology 37, no. 7_suppl (2019): 550. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.550.

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550 Background: In the phase 3 METEOR study (NCT01865747), cabo improved OS (median 21.4 vs 16.5 mo; HR, 0.66; 95% CI, 0.53–0.83), progression-free survival and objective response rate compared with eve in patients (pts) with previously treated advanced RCC (Choueiri 2016). Retrospective studies have shown that early tumour shrinkage (eTS), based on target lesion reduction from baseline to first post-baseline scan, has predictive value for targeted therapies in RCC (Grunwald 2015; Grunwald 2016); here we evaluate its impact on OS in METEOR. Methods: In total, 658 pts were randomized 1:1 to rec

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Sun, Fengwu, Eiichi Egami, Pablo G. Pérez-González, et al. "Extensive Lensing Survey of Optical and Near-infrared Dark Objects (El Sonido): HST H-faint Galaxies behind 101 Lensing Clusters." Astrophysical Journal 922, no. 2 (2021): 114. http://dx.doi.org/10.3847/1538-4357/ac2578.

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Abstract We present a Spitzer/IRAC survey of H-faint (H 160 ≳ 26.4, < 5σ) sources in 101 lensing cluster fields. Across a CANDELS/Wide-like survey area of ∼648 arcmin2 (effectively ∼221 arcmin2 in the source plane), we have securely discovered 53 sources in the IRAC Channel-2 band (CH2, 4.5 μm; median CH2 = 22.46 ± 0.11 AB mag) that lack robust HST/WFC3-IR F160W counterparts. The most remarkable source in our sample, namely ES-009 in the field of Abell 2813, is the brightest H-faint galaxy at 4.5 μm known so far (CH2 = 20.48 ± 0.03 AB mag). We show that the H-faint sources in our sample are

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Saleh, Ramadan, Essam Nada, Ahmed F. Hamed, and Wesam M. Hussien. "Epidemiologic Trends of Viral Skin Infections in Egypt: A Cross-Sectional Hospital-Based Study." Dermatology Research and Practice 2019 (March 27, 2019): 1–4. http://dx.doi.org/10.1155/2019/5469726.

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Viral skin infections (VSIs) were ranked among the top 50 prevalent diseases in 2010. The objective of this study was to determine the epidemiologic features of VSIs in patients attending a dermatology clinic in Egypt from June 2010 to May 2011. Patient’s residence, occupation, housing data, and family history of similar conditions were recorded. Categorical data were recorded as frequencies and percentages and were compared by Chi square test. P value < 0.05 was significant. Diagnosis of VSIs was made in 1000/20322 (4.9%) patients. Out of the 1000 patients with VSIs, 580 (58.0%) were resid

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Martin, Brian J., Martin J. MacInnis, Jenna B. Gillen, Lauren E. Skelly, and Martin J. Gibala. "Short-term green tea extract supplementation attenuates the postprandial blood glucose and insulin response following exercise in overweight men." Applied Physiology, Nutrition, and Metabolism 41, no. 10 (2016): 1057–63. http://dx.doi.org/10.1139/apnm-2016-0169.

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Green tea extract (GTE) ingestion improves glucose homeostasis in healthy and diabetic humans, but the interactive effect of GTE and exercise is unknown. The present study examined the effect of short-term GTE supplementation on the glycemic response to an oral glucose load at rest and following an acute bout of exercise, as well as substrate oxidation during exercise. Eleven sedentary, overweight men with fasting plasma glucose (FPG) ≥5.6 mmol·L−1 (age, 34 ± 13 years; body mass index = 32 ± 5 kg·m−2; FPG = 6.8 ± 1.0; mean ± SD) ingested GTE (3× per day, 1050 mg·day–1 total) or placebo (PLA) f

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Bichha, R. P., K. K. Jha, V. S. Salhotra, A. P. Weerakoon, K. B. Karki, and Navneet Bichha. "An Epidemiological Study to Find out Risk Factors of Multi Drugs Resistance Tuberculosis in Nepal." SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS 14, no. 2 (2018): 31–38. http://dx.doi.org/10.3126/saarctb.v14i2.19335.

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Introduction: Drug resistant tuberculosis is a threat to tuberculosis control worldwide. Previous anti- tuberculosis treatment is a widely reported risk factor for multi drug resistant tuberculosis (MDR-TB), whereas other risk factors are less well described. In Nepal National Tuberculosis Control Programme initiated DOTSPLUS Pilot project from September 2005 using standardized treatment regimen.Objective: To explore the risk factors for MDR-TB in Nepal.Methodology: Institution based matched case control study with a case: control ratio of 1:2 was carried out in three regions of Nepal. Fifty f

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Van der Heijde, D., X. Baraliakos, M. Dougados, et al. "OP0019 BIMEKIZUMAB IN PATIENTS WITH ACTIVE ANKYLOSING SPONDYLITIS: 24-WEEK EFFICACY & SAFETY FROM BE MOBILE 2, A PHASE 3, MULTICENTRE, RANDOMISED, PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 12–13. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2441.

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BackgroundBimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. In a phase 2b study, BKZ showed rapid and sustained efficacy and was well tolerated up to 156 weeks (wks) in patients (pts) with active ankylosing spondylitis (AS).1,2ObjectivesTo assess efficacy and safety of BKZ vs placebo (PBO) in pts with active AS up to Wk 24 in the ongoing pivotal phase 3 study, BE MOBILE 2.MethodsBE MOBILE 2 (NCT03928743) comprises a 16-wk double-blind, PBO-controlled period and 36-wk maintenance period. Pts were aged ≥18 yrs, met modified New York criteria

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Jain, Punit, Prashant Deshpande, Anu Korula, et al. "Adult Acute Lymphoblastic Leukemia: A Cost Effective Strategy and Limitations of Intensification of Therapy in India." Blood 126, no. 23 (2015): 3732. http://dx.doi.org/10.1182/blood.v126.23.3732.3732.

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Abstract Current treatment strategies in adult acute lymphoblastic leukemia (ALL) demonstrate a long term overall survival (OS) of 30 to 54%. Improvements in OS have been attributed to increased intensification (HD-MTX), novel intensive combination therapies such as HCVAD (Kantarjian et al. JCO: 2000) and allogeneic HSCT. There is paucity of real world data, especially from developing countries on impact of such therapeutic intensifications in context of challenges such as cost of therapy, multi-drug resistant bacterial infections and poor compliance. In this retrospective study, we present th

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Park, Il-Kyoo, Anjali Mishra, Jason C. Chandler, and Michael A. Caligiuri. "Effective Targeting of Acute Myeloid Leukemia (AML) Harboring the FLT3 ITD Mutation through the Axl/Gas6 Pathway." Blood 116, no. 21 (2010): 500. http://dx.doi.org/10.1182/blood.v116.21.500.500.

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Abstract Abstract 500 Approximately 30% of AML patients harbor activating mutant forms of Fms-like tyrosine kinase-3 (FLT3) such as internal tandem duplications (ITD). To date, targeting FLT3 ITD+ AML patients with FLT3 inhibitors has not improved outcomes, suggesting alternative strategies should be pursued. Axl is a type III receptor tyrosine kinase (RTK) which is, along with its ligand Gas6, over-expressed in AML leukemic blasts and correlated with a poor prognosis. In the present study, we asked if blocking the autocrine Axl/Gas6 pathway could impact aberrant proliferation and survival of

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Abramson, Jeremy S., Maria Lia Palomba, Leo I. Gordon, et al. "Five-Year Survival of Patients (pts) from Transcend NHL 001 (TRANSCEND) Supports Curative Potential of Lisocabtagene Maraleucel (liso-cel) in Relapsed or Refractory (R/R) Large B-Cell Lymphoma (LBCL)." Blood 144, Supplement 1 (2024): 3125. https://doi.org/10.1182/blood-2024-200204.

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Background: TRANSCEND (NCT02631044) demonstrated high ORR/CR rate with a manageable safety profile in R/R LBCL. At 2-y follow-up, liso-cel showed durable remissions (median duration of response [DOR], 23.1 mo) with no new safety signals (Abramson JS, et al. Blood 2024). In ZUMA-1, axicabtagene ciloleucel (axi-cel) showed a median OS of 25.8 mo with 5-y OS rate of 42.6% and 5-y disease-specific survival (DSS) rate of 51.0% (Neelapu SS, et al. Blood 2023). Here, we present 5-y survival results in the LBCL cohort of TRANSCEND, including data from the long-term follow-up (LTFU; NCT03435796) study.

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Torres, N. F., M. C. C. Bussiere, K. S. Nogueira, D. F. Dubeibe, and C. L. M. Souza. "283 ROLE OF iNOS/NO/cGMP PATHWAY ON IN VITRO MATURATION OF BOVINE COCs CO-CULTURED WITH HEMI-SECTIONS OF FOLLICULAR WALL." Reproduction, Fertility and Development 27, no. 1 (2015): 230. http://dx.doi.org/10.1071/rdv27n1ab283.

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Nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) works by stimulating the activity of the enzyme soluble guanylate cyclase (sGC) to synthesise cGMP, which has action in metabolism of PDE3A. Thus, NO controls the concentration of cAMP in the oocyte. The intraoocyte concentration of these cyclic nucleotides is directly linked to the control of maturation in rodents. The follicular wall hemi-sections (HS) in maturation medium partially inhibit nuclear maturation of oocytes in culture, which allows us to study the mechanism of meiosis resumption in bovines. The aim of this stu

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Wang, Xiaoli, Sonam Prakash, Min Lu, Yan Li, Attilio Orazi, and Ronald Hoffman. "Characterization of Splenic CD34+ Cells From Patients with Primary Myelofibrosis." Blood 118, no. 21 (2011): 2810. http://dx.doi.org/10.1182/blood.v118.21.2810.2810.

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Abstract Abstract 2810 Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by abnormal trafficking of hematopoietic stem cells (HSC) and hematopoietic progenitor cells (HPC), resulting in their constitutive mobilization and the establishment of extramedullary hematopoiesis. The mechanism by which HSC/HPC preferentially migrate, reside, proliferate and differentiate in the spleen remains poorly understood. We phenotypically and functionally characterized PMF splenic CD34+ cells (PMFSC) (n=8). Greater numbers of CD34+ (5.9±1.9%), CD34+CD38- (3.2±1.6%), CD34+CD90+ (2.0±1.5%

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Mastropolo, Rosemarie, Colin Cernik, Hajime Uno, et al. "Evolution in Documented Goals of Care at End of Life for Adolescents and Younger Adults With Cancer." JAMA Network Open 7, no. 12 (2024): e2450489. https://doi.org/10.1001/jamanetworkopen.2024.50489.

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ImportanceLittle is known about the nature of change in goals of care (GOC) over time among adolescents and younger adult (AYA) patients aged 12 to 39 years with cancer near the end of life. Understanding how GOC evolve may guide clinicians in supporting AYA patients in making end-of-life decisions.ObjectiveTo assess frequency, timing, and evolution of documented GOC among AYA patients with cancer in the last 90 days of life.Design, Setting, and ParticipantsThis cross-sectional study included a retrospective review of medical records from the Dana-Farber Cancer Institute, Kaiser Permanente Nor

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Antoni, Rona, Kelly L. Johnston, Adam L. Collins, and M. Denise Robertson. "Intermittentv. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants." British Journal of Nutrition 119, no. 5 (2018): 507–16. http://dx.doi.org/10.1017/s0007114517003890.

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AbstractThe intermittent energy restriction (IER) approach to weight loss involves short periods of substantial (>70 %) energy restriction (ER) interspersed with normal eating. Studies to date comparing IER to continuous energy restriction (CER) have predominantly measured fasting indices of cardiometabolic risk. This study aimed to compare the effects of IER and CER on postprandial glucose and lipid metabolism following matched weight loss. In all, twenty-seven (thirteen male) overweight/obese participants (46 (sem3) years, 30·1 (sem1·0) kg/m2) who were randomised to either an IER interven

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Kutluk, M. Tezer, and Akif Yesilipek. "Pediatric cancer registry Turkey: 2009-2016 (TPOG & TPHD)." Journal of Clinical Oncology 35, no. 15_suppl (2017): e22015-e22015. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e22015.

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e22015 Background: Each year 300.000 new cancer cases are expected in children & adolescents aged 0-19 years at global level. Although the long term survival rates have been improved to 85% in high income countries it is lower than this LMICs. Pediatric registries are essential for planning, evaluation, comparison for pediatric cancer care. This study focuses to pediatric cancer registry in Turkey. Methods: Turkish Pediatric Oncology Group and Turkish Pediatric Hematology Association established a WEB based cancer registry in Turkey in 2002. The registry information for 2002-2008 was prese

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Li, J., M. Li, D. Wu, J. Zhou, S. O. Leung, and F. Zhang. "OP0210 EFFICACY AND SAFETY OF SM03, A RECOMBINANT ANTI-HUMAN CD22 MONOCLONAL ANTIBODY IN CHINESE PATIENTS WITH RHEUMATOID ARTHRITIS: A PHASE II RANDOMIZED, DOUBLE-BLIND, MULTI-DOSE, PLACEBO-CONTROLLED STUDY." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 131.1–131. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1383.

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Background:Rheumatoid arthritis (RA) is a common chronic inflammatory rheumatic disease in China. SM03 is a novel chimeric monoclonal antibody (mAb) specific to the B cell restricted antigen CD22 developed for the treatment of rheumatoid arthritis (RA) and other B cell related immunological diseases.Objectives:We aim to evaluate the efficacy and safety of SM03 in patients with moderately-to-severely active RA in China.Methods:In this 24-week Phase II randomized, double-blind, multi-dose, placebo-controlled study, 156 patients were randomized with ratio of 1:1:1 to receive 3600mg cumulative dos

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Siraj, Abdul K., Rong Bu, Maha Al-Rasheed, et al. "Association between Drug-Metabolizing Enzymes Polymorphisms and Diffuse Large B-Cell Lymphoma Risk in the Middle Eastern Population." Blood 108, no. 11 (2006): 2043. http://dx.doi.org/10.1182/blood.v108.11.2043.2043.

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Abstract The last four decades have seen significant increase in the incidence of non-Hodgkin’s lymphoma (NHL) as a possible result of increasing environmental carcinogens exposure. Based on the increasing evidence for the association between carcinogens exposure related cancer risk and xenobiotic gene polymorphisms. We have undertaken a case control study on xenobiotic gene polymorphisms in Saudi individuals with a diagnosis of diffuse large B-cell lymphoma (DLBCL). Polymorphisms in five genes (CYP1A1, GSTT1, GSTP1, GSTM1 and NQO1) were characterized in 187 individuals with DLBCL and 513 norm

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Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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Cinakli, H., D. Solmaz, E. Durak Ediboglu, et al. "AB1169 THE PRESENCE OF PSORİASİS MIGHT INCREASES STRUCTURAL DAMAGE IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1815.2–1815. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6266.

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BackgroundPsoriasis is one of the most common extra-articular involvement in axial spondyloarthritis (axSpA) patients.ObjectivesTo examine the effect of the presence of psoriasis on the clinical and radiological features of patients with axSpA.MethodsIn this single-center study, 657 axSpA patients (mean age; 39.9±11.7, male gender n:411 [62,7%,]) were included in this analysis, according to the criteria of the Assessment of Spondyloarthritis International Society (ASAS). In addition to the initial demographic, clinical and radiological characteristics of the patients, radiological damage and p

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Cappellini, Maria Domenica, Elliott Vichinsky, Renzo Galanello, Antonio Piga, Paul Williamson, and John B. Porter. "Long-Term Treatment with Deferasirox (Exjade®, ICL670), a Once-Daily Oral Iron Chelator, Is Effective in Patients with Transfusion-Dependent Anemias." Blood 110, no. 11 (2007): 2777. http://dx.doi.org/10.1182/blood.v110.11.2777.2777.

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Abstract Background: The efficacy and safety of deferasirox was established during five 1-year core trials. As many patients will require lifelong chelation therapy, assessing long-term efficacy and safety is important. In the core trials, initial doses were assigned by baseline liver iron concentration (LIC). A clear dose response was observed: 5/10 mg/kg/d doses were generally insufficient to balance iron intake from ongoing transfusions, while 20 and 30 mg/kg/d maintained or reduced iron balance, respectively. This analysis evaluates serum ferritin (SF) levels and cumulative safety data dur

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Sadaf Rizwan, Aesha, Bushra Mehmood, and Shahzadi Hannan Arshad. "Compare the Outcomes of Subcutaneous Drains versus No Drains in Patients with Repeated Cesarean Section." Pakistan Journal of Medical and Health Sciences 15, no. 9 (2021): 2579–81. http://dx.doi.org/10.53350/pjmhs211592579.

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Objective: The aim of this study is to compare the outcomes of subcutaneous drains versus no drains in patients with repeated cesarean section. Study Design: Randomized control trial Place and Duration: Conducted at Gyne & Obs Department, Shahida Islam Teaching Hospital Lodhran, during from 8-01-2020 to 8-08-2020. Methods: Total 90 pregnant women with repeated cesarean section were presented in this study. Patients were aged between 22-50 years. Detailed demographics of enrolled cases including age, body mass index, gestational age and parity were recorded after taking informed written con

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De Hooge, M., A. Ishchenko, S. Steinfeld, et al. "OP0055 MINIMAL RADIOGRAPHIC DAMAGE OF SACROILIAC JOINTS DETECTED IN PSORIATIC ARTHRITIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 37.1–37. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2392.

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Background:Psoriatic arthritis (PsA) is an inflammatory joint disease that is traditionally included in the Spondyloarthritis (SpA) spectrum. Prevalence and impact of axial involvement in PsA remains understudied but increasingly affects treatment decisions.Objectives:The first step, in this multi-purpose radiographic study, is to report on baseline radiographic damage of the sacroiliac joints (SIJ) in PsA patients from a prospective multicentre cohort study in private and academic rheumatology practices.Methods:Data from the Belgian Epidemiological Psoriatic Arthritis Study (BEPAS), a prospec

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Hwang, Sang Mee, Sang-ho Lee, Seong_Ho Kang, et al. "Is Acute Erythroid Leukemia a Transitional Stage from MDS to AML?: A Study by Fluorescence in Situ Hybridization and Cytogenetics." Blood 112, no. 11 (2008): 4867. http://dx.doi.org/10.1182/blood.v112.11.4867.4867.

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Abstract Background: Chromosomal abnormalities of acute erythroid leukemia (AEL) are reported to be complex and nonspecific. We compared the cytogenetic abnormalities of AEL to other subtypes of acute myeloid leukemia (AML) by G- band karyotyping and fluorescence in situ hybridization (FISH) techinique using 18 probes. Methods: 384 patients diagnosed with AML between January 2000 and December 2007 were classified morphologically by French-American-British classification. G-band karyotyping and FISH for 4 recurrent chromosomal abnormalities in AML [AML/ETO rearrangement, PML/RARa rearrangement,

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Iqbal, S., D. Yang, S. Cole, et al. "Phase II study of capecitabine and gemcitabine in patients with metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15077-e15077. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15077.

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e15077 Background: Failing standard chemotherapy, many mCRC patients (pts) maintain an adequate performance status necessitating therapeutic options. Preclinical data in CRC cell lines shows that 5-FU and gemcitabine have synergistic cytotoxicity by stabilization of thymidylate synthase resulting in stronger inhibition of DNA synthesis. Methods: The primary objective was to assess time to progression (TTP) in mCRC pts who had progressed on irinotecan and oxaliplatin therapy. Secondary objectives included response rate (RR), overall survival (OS), toxicity and correlates to assess genes in the

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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Lanzillotta, M., E. Della Torre, C. Campochiaro, G. Mancuso, and L. Dagna. "SAT0528 CLINICAL PHENOTYPES OF IGG4-RELATED DISEASE REFLECT DIFFERENCES IN EPIDEMIOLOGICAL FEATURES, SEROLOGICAL FINDINGS, AND PROGNOSTIC OUTCOMES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1221.1–1222. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1438.

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Background:Four clinical phenotypes of IgG4-Related Disease (IgG4-RD) have been recently identified by Latent Class Analysis (LCA) - Pancreato/biliary (Group 1); Retroperitoneum/Aortitis (Group 2); Head-and-neck limited (Group 3); Mickulicz/Systemic (Group 4) - but the relevance of this classification for patient management remains unknown (1,2).Objectives:We aimed to assess whether clinical judgment can replicate LCA classification and to evaluate potential differences in epidemiological features, serological findings, and disease outcomes between disease phenotypes.Methods:The study included

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Pujala, Shivakrishna, та Mamidala Estari. "Molecular Docking Analysis of Flavonoid Compounds with C. igneus for the Identification of Potential Effective α-amylase Inhibitors". High Technology Letters 28, № 12 (2022): 768–78. https://doi.org/10.5281/zenodo.7471102.

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<strong>Abstract</strong> Introduction:Diabetes mellitus is a group of metabolic disease characterized by hyperglycemia resulting from fault in insulin secretion, insulin action or both. most effective treatment for type 2 diabetes is the control of postprandial hyperglycemia after a meal. stabilization of blood glucose is necessary for diabetic patients, because it prevents hyperglycemia and the complexity associated with diabetes. Objective: The objective of this study is to evaluate the in silico activities of Costus igneusflavonoids on α-amylase. Methods: Human Pancreatic Alpha-Amyla

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