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Journal articles on the topic '668.402 86'

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Published: 8 June 2024
Last updated: 31 July 2025

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1

Rousselot, Philippe, Hyacinthe Johnson-Ansah, Françoise Huguet, et al. "Personalized Daily Doses of Imatinib By Therapeutic Drug Monitoring Increase the Rates of Molecular Responses in Patients with Chronic Myeloid Leukemia. Final Results of the Randomized OPTIM Imatinib Study." Blood 126, no. 23 (2015): 133. http://dx.doi.org/10.1182/blood.v126.23.133.133.

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Abstract Background Imatinib mesylate (IM) at 400 mg/d remains a standard for first line therapy in patients (pts) with newly diagnosed chronic phase CML (CP-CML). A sub analysis of the IRIS study (Larson et al. Blood, 2008) demonstrated that pts with high IM trough levels achieved higher rates of major molecular response (MMR). The level of 1000 ng/ml was established as the [C]min value threshold to predict molecular response (Picard et al. Blood, 2007). We conducted a randomized trial to evaluate the value of IM dose optimization based on the monitoring of [C]min levels in newly diagnosed CP
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2

Raghunandan, K., and Dasaratha V. Rama. "SOX Section 404 Material Weakness Disclosures and Audit Fees." AUDITING: A Journal of Practice & Theory 25, no. 1 (2006): 99–114. http://dx.doi.org/10.2308/aud.2006.25.1.99.

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Section 404 of the Sarbanes-Oxley Act and Auditing Standard No. 2 (PCAOB 2004) require management and the auditor to report on internal controls over financial reporting. Section 404 is arguably the most controversial element of SOX, and much of the debate around the costs of implementing section 404 has focused on auditors' fees (Ernst & Young 2005). In this paper, we examine the association between audit fees and internal control disclosures made pursuant to section 404. Our sample includes 660 manufacturing firms that have a December 31, 2004 fiscal year-end and filed the section 404 re
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Dosmagambetov, S. P., B. K. Dzhenalaev, A. B. Tusupkaliev, et al. "The current state of diagnostics and management of foreign bodies in the respiratory tract in children." Russian Journal of Pediatric Surgery 27, no. 2 (2023): 137–42. http://dx.doi.org/10.55308/1560-9510-2023-27-2-137-142.

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Introduction. Foreign body aspiration (FBA) into the respiratory tract is a severe, life-threatening condition in children which requires urgent medical and diagnostic measures. Purpose. To study outcomes after FBA diagnostics and treatment in children and to develop an algorithm for diagnosing foreign bodies in the respiratory tract in this group of patients. Material and methods. Outcomes in 86 children who were hospitalized with suspected foreign bodies in their respiratory tract to the Clinic of Pediatric Surgery in Marat Ospanov West Kazakhstan Medical University, Aktobe, Republic of Kaza
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Maradiaga-Rodriguez, Walter Danilo, Adão Wagner Pêgo Evangelista, José Alves-Júnior, and Rommel Bernardes-da Costa. "Effects of vinasse and lithothanmium application on the initial growth of sugar cane (Saccharum sp. cv. RB 86-7515) irrigated and not irrigated." Acta Agronómica 67, no. 2 (2018): 252–57. http://dx.doi.org/10.15446/acag.v67n2.66082.

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El objetivo de este estudio es evaluar el crecimiento inicial de la caña de azúcar variedad RB 86-7515, cultivada en sistema de producción orgánica y fertilizada con dosis de lithothanmium y vinaza, se desarrolló un experimento. La investigación se llevó a cabo en la Escuela de Agronomía de la Universidade Federal de Goiás, Brasil. El delineamiento estadístico fue en un diseño completamente aleatorio con tres repeticiones, en esquema factorial (5 x 5 x 2). Las plantas fueron cultivadas en contenedores de plástico de 200 litros. Los tratamientos correspondieron a cinco dosis de vinaza (0, 165,
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Maradiaga, Walter Danilo, Adão Wagner Pêgo Evangelista, José Alves Júnior, Wilson Mozena Leandro, Marcus Vinicius Honorato Domingos, and Derblai Casaroli. "LITHOTHAMNIUM E VINHAÇA NA PRODUÇÃO DE CANA-DE-AÇÚCAR ORGÂNICA IRRIGADA E DE SEQUEIRO." IRRIGA 23, no. 2 (2018): 390–401. http://dx.doi.org/10.15809/irriga.2018v23n2p390-401.

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LITHOTHAMNIUM E VINHAÇA NA PRODUÇÃO DE CANA-DE-AÇÚCAR ORGÂNICA IRRIGADA E DE SEQUEIRO
 
 
 WALTER DANILO MARADIAGA RODRIGUEZ1; ADÃO WAGNER PÊGO EVANGELISTA1; JOSÉ ALVES JÚNIOR1; WILSON MOZENA LEANDRO1; MARCUS VINICIUS HONORATO DOMINGOS1 E DERBLAI CASAROLI1
 
 ¹Núcleo de Pesquisa em Clima e Recursos Hídricos do Cerrado – Escola de Agronomia - Universidade Federal de Goiás, Rodovia Goiânia / Nova Veneza, Km 0, Goiânia, Goiás, CEP: 74690-900, E-mail: maradiagawd@gmail.com, awpego@bol.com.br, josealvesufg@yahoo.com.br, wilsonufg@gmail.com, derblaicasaroli@yahoo.com.br, mar
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Ghufron, Muhammad, Fitri Nur Indah Sari, Brahmanu Wisnu Saputro, and Jyh-Ming Ting. "Metal Doping in 2D Co3O4 for Enhanced ORR/OER Electrocatalytic Performance." ECS Meeting Abstracts MA2023-02, no. 4 (2023): 527. http://dx.doi.org/10.1149/ma2023-024527mtgabs.

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Spinel cobalt oxide or Co3O4, has been proven to be a promising material as bifunctional electrocatalyst for ORR/OER. In this study, we show further improvement of the electrocatalytic activity via metal doping. Metal-doped Co3O4 was synthesized using a simple hydrothermal method at 120° C for 24 h, followed by calcination at 400° C for 1 h. A surfactant was used to control the morphology of the sample such that either 1D or 2D structure was obtained. The 2D structure shows better electrical conductivity with Rct of 70 Ohm vs. 86 Ohm for the 1D structure. Electrochemical test show that the 2D
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Cho, Gye-Hong, Ye-Ji Kim, Koeun Jeon, Hye-Jun Joo, and Kyu-Suk Kang. "Accuracy Evaluation of Visible-Near Infrared Spectroscopy for Detecting Insect Damage in Acorns of Quercus acuta." Silvae Genetica 73, no. 1 (2024): 99–109. http://dx.doi.org/10.2478/sg-2024-0010.

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Abstract This study aimed to test near-infrared spectroscopy to assess insect damage to oak acorns collected from a seed orchard of Quercus acuta in Jeju Island, Korea. A total of 550 acorns were sorted into 362 sound and 178 unsound (insect-damaged) acorns, followed by near-infrared spectroscopy. To minimize spectral data errors, preprocessing techniques such as first derivative, multiplicative scatter correction, standard normal variate, and Savitzky-Golay filter were applied, along with multivariate analysis methods like partial least squares. Then the model performance, including accuracy
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8

Bendell, Johanna C., Bert H. O'Neil, Alexander Starodub, et al. "Cancer stemness inhibition and chemosensitization: Phase 1b/II study of cancer stemness inhibitor napabucasin (BBI-608) with FOLFIRI +/- bevacizumab (Bev) administered to colorectal cancer (CRC) patients (pts)." Journal of Clinical Oncology 35, no. 4_suppl (2017): 593. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.593.

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593 Background: Cancer stem cells or stemness-high cancer cells are considered to be fundamentally important for resistance to therapy, recurrence and metastasis. Napabucasin, a first-in-class cancer stemness inhibitor in clinical development, suppresses cancer stemness by targeting Stat3-driven gene transcription. Preclinical studies suggest that napabucasin sensitizes heterogeneous cancer cells to chemotherapeutics and targeted agents. Methods: This study was performed to assess signs of anti-tumor activity of napabucasin in combination with FOLFIRI +/- Bev in CRC pts. Napabucasin was admini
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Armstrong, I., G. Swant, and H. R. Timmermann. "Developing a woodland caribou habitat mosaic on the Ogoki-Nakina North Forests of northwestern Ontario." Rangifer 18, no. 5 (1998): 235. http://dx.doi.org/10.7557/2.18.5.1561.

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The Ogoki-North Nakina Forests consist of (10 638 km2) unroaded boreal forest approximately 400 km northeast of Thunder Bay, Ontario (lat 50°- 51°31'N, long 86°30'- 89°W). Woodland caribou (Rangifer tarandus caribou) inhabit discrete portions within these forests based on minimal current and past historical data. As part of the Forest Management Planning process, for the period 1997-2097, a woodland caribou habitat mosaic has been developed to coordinate present and future forest management activities with the retention and development of current and future wood
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Rose, Susannah, Heather McKee Hurwitz, Mary Beth Mercer, et al. "Patient Experience in Virtual Visits Hinges on Technology and the Patient-Clinician Relationship: A Large Survey Study With Open-ended Questions." Journal of Medical Internet Research 23, no. 6 (2021): e18488. http://dx.doi.org/10.2196/18488.

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Background Patient satisfaction with in-person medical visits includes patient-clinician engagement. However, communication, empathy, and other relationship-centered care measures in virtual visits have not been adequately investigated. Objective This study aims to comprehensively consider patient experience, including relationship-centered care measures, to assess patient satisfaction during virtual visits. Methods We conducted a large survey study with open-ended questions to comprehensively assess patients’ experiences with virtual visits in a diverse patient population. Adults with a virtu
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11

Kojima, Takashi, Kei Muro, Eric Francois, et al. "Pembrolizumab versus chemotherapy as second-line therapy for advanced esophageal cancer: Phase III KEYNOTE-181 study." Journal of Clinical Oncology 37, no. 4_suppl (2019): 2. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.2.

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2 Background: Patients with advanced esophageal cancer after first-line chemotherapy (chemo) have a poor prognosis and limited treatment options. We present results of the phase 3 KEYNOTE-181 study of pembrolizumab vs investigator’s choice chemo as second-line therapy for patients (pts) with advanced/metastatic squamous cell carcinoma (SCC) and adenocarcinoma of the esophagus or Siewert type I adenocarcinoma of the EGJ (NCT02564263). Methods: Eligible pts were randomized 1:1 to pembrolizumab 200 mg Q3W for up to 2 years or investigator’s choice chemo of paclitaxel, docetaxel, or irinotecan. Ra
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Budnikova, E. A., O. I. Kubar, O. V. Iozefovich, and S. M. Kharit. "The study of the formation processes and signs of the likelihood of vaccination in priority contingents in various epidemic diseases (sociological research)." Journal Infectology 15, no. 2 (2023): 123–31. http://dx.doi.org/10.22625/2072-6732-2023-15-2-123-131.

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The purpose of the study: to determine the development of vaccination against infections associated with contingents in an epidemic crisis.Materials and methods: the method of a sociological survey of future workers and those vaccinated in different epidemic status periods was used: 2019 – the pre-pandemic period and 2020 – the period of the COVID-19 pandemic. A sociological survey was conducted in 2019 among 212 medical workers (130 doctors and 82 nurses) and among 229 medical workers in 2020 (143 doctors and 86 nurses). Parents were also interviewed using a questionnaire. 100 and 50 responde
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Silvero, Melina, Francisco Crespo, Maria del Mar Serra Pesquer, et al. "PSIX-8 Supplementing a Natural Citrus Flavonoid Extract (Bioflavex) to Finishing Cattle." Journal of Animal Science 100, Supplement_3 (2022): 372–73. http://dx.doi.org/10.1093/jas/skac247.681.

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Abstract Finishing cattle are exposed to diets with high amounts of starch and consequently to hindgut acidosis. Usually, antibiotics like ionophores are used to control dysbiosis at gut level. However, natural options are being evaluated as healthy alternatives. Flavonoids are well known as antibacterial agent, being an interesting alternative to antibiotics. The aim of this experiment was to evaluate the performance of finishing steers supplemented with monensin compared with citrus flavonoid extract (Bioflavex). Steers (n = 48; 214.3 kg live weight; LW) were assigned to two treatments: Mone
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14

Silva, Jean Jerley N., Wander R. Pavanelli, José Clayston M. Pereira, João S. Silva, and Douglas W. Franco. "Experimental Chemotherapy against Trypanosoma cruzi Infection Using Ruthenium Nitric Oxide Donors." Antimicrobial Agents and Chemotherapy 53, no. 10 (2009): 4414–21. http://dx.doi.org/10.1128/aac.00104-09.

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ABSTRACT The ruthenium NO donors of the group trans-[Ru(NO)(NH3)4L] n+, where the ligand (L) is N-heterocyclic H2O, SO3 2−, or triethyl phosphite, are able to lyse Trypanosoma cruzi in vitro and in vivo. Using half-maximal (50%) inhibitory concentrations against bloodstream trypomastigotes (IC50 try) and cytotoxicity data on mammalian V-79 cells (IC50 V79), the in vitro therapeutic indices (TIs) (IC50 V79/IC50 try) for these compounds were calculated. Compounds that exhibited an in vitro TI of ≥10 and trypanocidal activity against both epimastigotes and trypomastigotes with an IC50 try/epi of
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Carreño, Heider, Elena E. Stashenko, and Patricia Escobar. "Essential Oils Distilled from Colombian Aromatic Plants and Their Constituents as Penetration Enhancers for Transdermal Drug Delivery." Molecules 28, no. 6 (2023): 2872. http://dx.doi.org/10.3390/molecules28062872.

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The study aimed to determine the enhanced effects of essential oils (EOs) and plant-derived molecules (PDMs) as penetration enhancers (PEs) for transdermal drug delivery (TDD) of caffeine. A 1% w/w solution of eight EOs and seven PDMs was included in the 1% caffeine carbopol hydrogel. Franz diffusion cell experiments were performed using mice with full-thickness skin. At various times over 24 h, 300 μL of the receptor were withdrawn and replaced with fresh medium. Caffeine was analyzed spectrophotometrically at 272 nm. The skin irritation effects of the hydrogels applied once a day for 21 days
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Gubina, A. A., E. V. Levin, M. M. Romanovich, et al. "Optimal Spectral Radiation Composition of a LED Phytolapm for Stimulating Carrot and Tomato Seed Development." Journal of the Russian Universities. Radioelectronics 25, no. 3 (2022): 62–72. http://dx.doi.org/10.32603/1993-8985-2022-25-3-62-72.

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Introduction. Light-emitting diode (LED) irradiation is widely used in various spheres of human activity, including agriculture. Due to the growing urban population and aggravating environmental situation, the problem of high-quality food provision is increasingly attracting research attention. In this context, it is important to develop energy-efficient optical systems for ensuring optimal irradiation conditions for accelerating the growth of various types of plants and improving the quality of products in autonomous agro-industrial complexes.Aim. Determination of an optimal spectral radiatio
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17

Shen, Lin, Ken Kato, Sung-Bae Kim, et al. "RATIONALE 302: Randomized, phase 3 study of tislelizumab versus chemotherapy as second-line treatment for advanced unresectable/metastatic esophageal squamous cell carcinoma." Journal of Clinical Oncology 39, no. 15_suppl (2021): 4012. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.4012.

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4012 Background: Tislelizumab (tisle) monotherapy or plus chemotherapy demonstrated antitumor activity in patients (pts) with solid tumors, including esophageal squamous cell carcinoma (ESCC) (NCT03469557 and CTR20160872). Methods: In this global phase 3 study (NCT03430843), adults with histologically confirmed advanced/unresectable or metastatic ESCC whose disease progressed following prior systemic therapy with ≥1 evaluable lesion per RECIST v1.1 and an Eastern Cooperative Oncology Group performance score (ECOG PS) of ≤1 were included. Pts were randomized (1:1) to receive tisle 200 mg intrav
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Barclay, Johanna L., Carolyn J. Petersons, Sahar Keshvari, et al. "Thrombospondin-1 is a glucocorticoid responsive protein in humans." European Journal of Endocrinology 174, no. 2 (2016): 193–201. http://dx.doi.org/10.1530/eje-15-0964.

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ObjectiveThrombospondin-1 (TSP1) is a matricellular protein whose gene expression has previously been shown to increase acutely after exposure to dexamethasone in vitro. The aim of this study was to determine if TSP1 is altered by acute and chronic states of glucocorticoid excess in human subjects.Design and methodsThree studies have been undertaken to assess the difference or change in TSP1 in response to altered glucocorticoid activity: i) an acute interventional study assessed the effects of a single 4 mg dose of dexamethasone in 20 healthy volunteers; ii) a cross-sectional study compared p
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Lykas, Christos, Constantinos Kittas, Nikolaos Katsoulas, and Maria Papafotiou. "Gardenia jasminoides Height Control Using a Photoselective Polyethylene Film." HortScience 43, no. 7 (2008): 2027–33. http://dx.doi.org/10.21273/hortsci.43.7.2027.

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The use of chemical growth retardants is a standard practice for compact gardenia plant production. The aim of this study was to investigate the possibility of using a photoselective polyethylene greenhouse covering film as an alternative to chemical treatment for production of compact potted gardenia (Gardenia jasminoides Ellis) plants. Two types of experiments were carried out: 1) on gardenia cuttings rooted in rooting benches; and 2) on young potted plants grown under low tunnels. In both experiments, two types of cover materials were used: 1) a photoselective polyethylene (P-PE), filtering
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Ding, Dale, Chun-Po Yen, Zhiyuan Xu, Robert M. Starke, and Jason P. Sheehan. "Radiosurgery for patients with unruptured intracranial arteriovenous malformations." Journal of Neurosurgery 118, no. 5 (2013): 958–66. http://dx.doi.org/10.3171/2013.2.jns121239.

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Object The appropriate management of unruptured intracranial arteriovenous malformations (AVMs) remains controversial. In the present study, the authors evaluate the radiographic and clinical outcomes of radiosurgery for a large cohort of patients with unruptured AVMs. Methods From a prospective database of 1204 cases of AVMs involving patients treated with radiosurgery at their institution, the authors identified 444 patients without evidence of rupture prior to radiosurgery. The patients' mean age was 36.9 years, and 50% were male. The mean AVM nidus volume was 4.2 cm3, 13.5% of the AVMs wer
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Lezhenina, S., N. Shuvalova, and E. Guryanova. "AB1569-PARE WHAT DO PATIENTS KNOW ABOUT RHEUMATOID ARTHRITIS?" Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1884.2–1884. http://dx.doi.org/10.1136/annrheumdis-2022-eular.628.

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BackgroundPatient awareness of rheumatoid arthritis (RA) contributes to more effective prevention of this disease. It is necessary to study the initial level of knowledge of patients about rheumatoid arthritis and analyze which sections of the educational program need to be studied carefully.ObjectivesTo analyze what patients know about rheumatoid arthritis, and do patients with this nosology want to be trained in various educational programs?MethodsA survey of 86 patients with RA of varying severity was conducted. The diagnosis of RA was established according to the (EULAR)/ACR criteria. Pati
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22

Koniukhovskaia, J., E. Pervichko, O. Stepanova, and E. Dorokhov. "Psychopathological symptoms among the russian population during the COVID-19 pandemic in the spring of 2020." European Psychiatry 64, S1 (2021): S305. http://dx.doi.org/10.1192/j.eurpsy.2021.821.

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IntroductionThe COVID-19 pandemic has affected the lifestyle and psychological well-being of millions of people.ObjectivesThe aim of the study was to assess the prevalence of psychopathological symptoms in the Russian population in the COVID- 19 pandemic context.MethodsWe used a socio-demographic questionnaire (20 questions) and a Short Scale for Psychopathological Symptom Checklist (SCL -32) (Derogatis 1977; Mitina, Gorbunova, 2011). 582 Russian residents (496 women and 86 men) aged 18-64 years participated in the online survey in May 2020.ResultsWomen were significantly more likely than men
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Lee, Yun Jeong, Seung Chan Lee, Seo Young Wy, et al. "Ocular Manifestations, Visual Field Pattern, and Visual Field Test Performance in Traumatic Brain Injury and Stroke." Journal of Ophthalmology 2022 (January 7, 2022): 1–6. http://dx.doi.org/10.1155/2022/1703806.

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Purpose. To analyze ocular manifestations, visual field (VF) pattern, and VF test performance in traumatic brain injury (TBI) and stroke patients. Methods. This retrospective, cross-sectional study included 118 patients (236 eyes) with TBI and stroke who had undergone VF testing by standard automated perimetry with the central 24-2 threshold test. Clinical features including best-corrected visual acuity (BCVA), intraocular pressure (IOP), ocular manifestations, and VF test results including VF defect pattern, reliability, and global indices were analyzed and compared between the TBI and stroke
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Chen, Ying, Yifan Chu, Wen Yao, Luyao Wang, Wanjiang Zeng, and Jing Yue. "Comparison of Cumulative Live Birth Rates between Flexible and Conventional Progestin-Primed Ovarian Stimulation Protocol in Poor Ovarian Response Patients According to POSEIDON Criteria: A Cohort Study." Journal of Clinical Medicine 12, no. 18 (2023): 5775. http://dx.doi.org/10.3390/jcm12185775.

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Research Question: To compare the cumulative live birth rate (CLBR) per oocyte retrieval cycle of a conventional progestin-primed ovarian stimulation (cPPOS) regimen with a flexible progestin-primed ovarian stimulation (fPPOS) regimen in poor ovarian response patients, according to POSEIDON criteria. Design: Poor ovarian response women, according to POSEIDON criteria, who underwent the first PPOS protocol for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) between January 2018 and December 2020 were included. The fPPOS group involved 113 participants, and the cPPOS group inc
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Kim, Dong-Wook, Camille Granvil, Eren Demirhan, et al. "Comparison of Steady-State Imatinib (IM) Trough Levels, Clinical Response, and Safety Between Caucasian and Asian Patients with Chronic Lyeloid Leukemia in Chronic Phase (CML-CP) Treated with 400mg and 800mg Daily Doses of IM in the Tyrosine Kinase Inhibitor Optimization and Selectivity (TOPS) Study." Blood 114, no. 22 (2009): 1127. http://dx.doi.org/10.1182/blood.v114.22.1127.1127.

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Abstract Abstract 1127 Poster Board I-149 Background In the TOPS study, IM trough levels (Cmin) were collected from different race groups, mainly Caucasian and Asian, but also Black and others. Inter-ethnic differences in the PK of a drug are known to be important factors accounting for inter-individual variation in drug responsiveness. This analysis reports the comparison between Caucasian and Asian CML patients (pts) treated at doses of 400 mg QD and 400 mg bid (800 mg daily) of IM Cmin on Day 29 of initial treatment, clinical response, safety and tolerability. Methods Steady state IM Cmin o
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Barbosa, Patricia R., Sally P. Stabler, Mario H. Hirata, et al. "Effects of Methionine Synthase (MS) A2756G and Methionine Synthase Reductase (MSR) A66G Polymorphisms on Methionine Metabolism in Brazilian Pregnant Women and Their Neonates." Blood 104, no. 11 (2004): 3686. http://dx.doi.org/10.1182/blood.v104.11.3686.3686.

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Abstract Methionine synthase (MS) is a cobalamin dependent enzyme that catalyses the remethylation of homocysteine to methionine. The methionine synthase reductase (MSR) maintains adequate levels of methylcob(III)alamin, the activated cofactor for MS. The aim of this study was to investigate the effect of MS A2756G and MSR A66G polymorphisms on total homocysteine (tHcy), S-adenosylmethionine (SAM), S-adenosylhomocysteine (SAH) levels in 390 pregnant women and their 292 newborns, from Sorocaba city, Brazil. Genotypes of two polymorphisms were determined by PCR-RFLP. Pregnant women with MS 2756A
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Walker, Irwin R., Donald M. Arnold, and Jim A. Julian. "Survival of HIV Infected Individuals with Hemophilia after 20 Years: From the Canadian Hemophilia Registry." Blood 104, no. 11 (2004): 3085. http://dx.doi.org/10.1182/blood.v104.11.3085.3085.

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Abstract Background : Patients with hemophilia A and B have been tracked by the Canadian Hemophilia Registry since 1980. The total number on the Registry is 3307 (A=2721, B=586) of which 662 were/are HIV-positive. New HIV and HCV infections ceased after 1985 and 1988 respectively with the introduction of safer blood products; HIV-infected individuals with hemophilia therefore resemble a cohort with HIV infection that was acquired in a relatively narrow time period about 20 years ago. Current status of HIV-positive patients is Active 250 (37.8%), Deceased 406 (61.3%), Lost to Follow Up 9 (0.9%)
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Shamanna, Paramesh, Mala Dharmalingam, Arun Vadavi, et al. "Response to Twin Enabled Precision Treatment for Reversing Diabetes: An Initial Analysis at 4 Weeks of the Ongoing Randomised Controlled Trial." Journal of the Endocrine Society 5, Supplement_1 (2021): A474—A475. http://dx.doi.org/10.1210/jendso/bvab048.970.

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Abstract Introduction: Technology enabled precision nutrition, a combination of macro, micro and biota nutrients, along with Continuous Glucose Monitoring (CGM) have been demonstrated to be a key for reversal of diabetes. Methods: We conducted an initial analysis (n=23) of the ongoing randomized controlled trial of Twin Precision Treatment (TPT): a novel whole-body digital twin enabled precision treatment for reversing diabetes. The clinical and the biochemical parameters were evaluated as the longitudinal follow up at the first follow up visit at 4 weeks. The target sample size is 300 with an
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D’Onofrio, Rosario, Anas Radi Alashram, Giuseppe Annino, et al. "Prevention of Secondary Injury after Anterior Cruciate Ligament Reconstruction: Relationship between Pelvic-Drop and Dynamic Knee Valgus." International Journal of Environmental Research and Public Health 20, no. 4 (2023): 3063. http://dx.doi.org/10.3390/ijerph20043063.

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(1) Background: Optimal neuromuscular, Lumbo-Pelvic-Hip Complex, and lower extremity control are associated with decreased risk factors for secondary anterior cruciate ligament (ACL) injury. This study aimed to analyze any asymmetries and malalignments in the Lumbo-Pelvic-Hip Complex and the lower limbs at 6 months after ACL reconstruction (ACLR). (2) Methods: We conducted an exploratory retrospective observational single-center study in patients during the outpatient postoperative rehabilitation program at ICOT (Latina, Italy). From January 2014 to June 2020, 181 patients were recruited, but
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Main, Stephanie, Rina Triasih, Jane Greig, et al. "The prevalence and risk factors for tuberculosis among healthcare workers in Yogyakarta, Indonesia." PLOS ONE 18, no. 5 (2023): e0279215. http://dx.doi.org/10.1371/journal.pone.0279215.

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Healthcare workers (HCWs) are at risk of contracting TB, particularly when in high tuberculosis (TB) burden settings. Routine surveillance data and evidence are limited on the burden of TB amongst HCWs in Indonesia. We aimed to measure the prevalence of TB infection (TBI) and disease among HCWs in four healthcare facilities in Yogyakarta province in Indonesia, and explore risk factors for TBI. A cross-sectional TB screening study targeted all HCWs from four pre-selected facilities (1 hospital, 3 primary care) in Yogyakarta, Indonesia. Voluntary screening included symptom assessment, Chest X-ra
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Kroviakov, S. O., and V. O. Kryzhanovskyi. "INFLUENCE OF FIBER REINFORCEMENT ON CONCRETE SHRINKAGE FOR RIGID ROAD AND AIRFIELD PAVEMENT REPAIR." Bulletin of Odessa State Academy of Civil Engineering and Architecture, no. 84 (September 30, 2021): 78–86. http://dx.doi.org/10.31650/2415-377x-2021-84-78-86.

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Abstract. The influence of fiber reinforcement with steel anchor fiber on the shrinkage of modified concrete for rigid airfield pavements repair has been determined. A 2-factor experiment was carried out, in which the following composition factors were varied: the amount of hardening accelerator Sika Rapid 3 from 0 to 2.4% of the cement content (0-9.6 kg/m3); the amount of steel anchor fiber with 1 mm diameter and 50 mm length, from 0 to 100 kg/m3. For the concrete batching were used: Portland cement CEM II / AS 42.5 in the amount of 400 kg/m3, granite crushed stone 5-20 mm, quartz sand, plast
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32

Arellano-Rodrigo, Eduardo, Alberto Alvarez-Larran, Francisco Cervantes, Juan-Carlos Reverter, Neus Villamor, and Emili Montserrat. "Increased Platelet Turnover and Platelet P-Selectin in Patients with Essential Thrombocythemia and Thrombosis." Blood 104, no. 11 (2004): 4744. http://dx.doi.org/10.1182/blood.v104.11.4744.4744.

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Abstract Essential thrombocythemia (ET) is a myeloproliferative disorder associated with an increased tendency to thrombosis, the pathogenesis of which is not well known. The aim of the present study was to analyze the relationship between platelet turnover and activation and a history of thrombosis in patients with ET. The expression of platelet P-selectin (measured both in unstimulated platelets and after agonist-stimulation with ADP, thrombin, arachidonic acid (AA), collagen or epinephrine) and the percentage of reticulated platelets (RP) were measured in 53 ET patients with (n=26) or witho
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33

Brenner, Andrew Jacob, Yael Cohen, James J. Vredenburgh, et al. "Phase I/II dose-escalation study of VB-111, an antiangiogenic gene therapy, in patients with recurrent glioblastoma multiforme." Journal of Clinical Oncology 31, no. 15_suppl (2013): TPS2102. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.tps2102.

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TPS2102 Background: VB-111 is an anti-angiogenic agent consisting of a non-replicating adenovirus vector (Ad-5) with a modified murine pre-proendothelin promoter leading to apoptosis of tumor vasculature by expressing a fas-chimera transgene in angiogenic endothelial cells. In a phase I/II dose-escalation study, safety and efficacy of VB-111 in patients with recurrent Glioblastoma Multiforme (GBM) were evaluated. Methods: VB-111 was administered as a single intravenous infusion at escalating doses from 1x1012 to 3x1012 viral particles (VPs), followed by repeat doses of 3x1012 or 1x1013every 2
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34

Teterycz, Pawel, Tatsiana Sryukina, Agnieszka Kluz, et al. "Identifying the high risk group in stage pT1bN0 cutaneous melanoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): 9583. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.9583.

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9583 Background: In recent years, there has been a substantial improvement in prognosis for patients diagnosed with stage II or III melanoma due to the advent of adjuvant and neoadjuvant therapy. At the same time, significant percentage of melanoma deaths are caused by prevalent cases of thin melanoma. In this work, we aimed to identify the stage pT1bN0 melanoma subgroup with the worst prognosis. Methods: All cases of stage pT1b melanoma (with negative sentinel node biopsy) treated between 1998 and 2022 in high-throughput reference center were analyzed. Patients were followed for ten years or
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35

Ghanem, Hady A., Dan Jones, Hagop M. Kantarjian, et al. "Effect of FMS-Like Tyrosine Kinase-3 Mutations on Prognosis in Acute Myeloid Leukemia: A Single Institution Experience between 2000 and 2007." Blood 110, no. 11 (2007): 3489. http://dx.doi.org/10.1182/blood.v110.11.3489.3489.

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Abstract Mutations of the FMS-like tyrosine kinase-3 gene (FLT3), including internal tandem duplication (ITD) of the juxtamembrane domain or activating point mutations of the second tyrosine kinase domain involving codon 835 or 836 are among the most common molecular abnormalities in acute myeloid leukemia (AML). A clear negative impact of FLT3 mutation on survival has been demonstrated in AML patients younger than 60 years; however, this negative effect on prognosis or survival has not been confirmed in older patients. We evaluated 661 patients with AML treated at MD Anderson Cancer center be
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Iurlo, Alessandra, Roberto Latagliata, Cristina Bucelli, et al. "Very Elderly Patients with Chronic Phase-Chronic Myeloid Leukemia on Imatinib: No Impact of Concomitant Drugs on Complete Cytogenetic Response." Blood 126, no. 23 (2015): 1582. http://dx.doi.org/10.1182/blood.v126.23.1582.1582.

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Abstract Tyrosine-kinase inhibitors (TKIs)have completely changed the expected survival of chronic myeloid leukemia (CML) patients which is now approaching that of the general population: a relevant proportion of CML patients are currently elderly or very elderly. Very elderly patients represent generally a small proportion in published experiences. Older CML patients imatinib treated, as it happens in the general population, receive other drug treatments for associated chronic illnesses. Our aim is to assess if and which classes of concomitant drugs have an impact on cytogenetic response in c
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37

Rugo, Hope S., Sara M. Tolaney, Nancy Chan, et al. "Elacestrant (Ela) combinations with ribociclib (Ribo) and everolimus (Eve) in patients (pts) with ER+/HER2- locally advanced or metastatic breast cancer (mBC): Update from ELEVATE, a phase (Ph) 1b/2, open-label, umbrella study." Journal of Clinical Oncology 43, no. 16_suppl (2025): 1070. https://doi.org/10.1200/jco.2025.43.16_suppl.1070.

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1070 Background: Progression of ER+/HER2- mBC on 1L endocrine therapy (ET) + CDK4/6i is associated with several mechanisms of resistance that impact efficacy and subsequent therapy. Treatment options include endocrine monotherapy, continuing ET+CDK4/6i, or PI3K/AKT/mTOR pathway–ET combination regimens. Acquired ESR1 mutations emerge in up to 50% of patients and continuing SOC ET is limited by resistance to ET due to these mutations. Several trials have shown improved mPFS with the addition of Eve: 3.6-6.8 mo (Cook 2021, Vasseur 2024) or switch in CDK4/6i: 5.3 mo (Kalinsky 2023). In the Ph 3 EM
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38

Varghese, Abraham Mullasseril, Lauren Wright, Talha Munir, Russell Patmore, Catherine Parbutt, and Alexandra Smith. "Population-Based Registry Data over 15 Years Suggests Comparable Overall Survival for CLL Patients Treated with Chemoimmunotherapy and Targeted Therapies As First-Line Treatments." Blood 144, Supplement 1 (2024): 5122. https://doi.org/10.1182/blood-2024-201655.

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Phase 3 clinical trials have shown that targeted therapies (TT), significantly improve progression-free survival (PFS) compared to chemoimmunotherapy (CIT) for patients with chronic lymphocytic leukemia (CLL) with very few demonstrating a difference in overall survival (OS). TT are now the preferred first-line treatment for CLL patients across all age groups. Nevertheless, evidence demonstrating differences in OS in real-world settings remains scarce. This study aims to evaluate OS in patients who began treatment with either chemotherapy (CT) or CIT compared to those who received TT as their f
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39

Gandhi, Shipra, Sachin Kumar Deshmukh, Sharon Wu, et al. "Chemokines as predictive biomarkers for immune checkpoint inhibitor (ICI) efficacy in triple negative breast cancer (TNBC)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 1106. https://doi.org/10.1200/jco.2025.43.16_suppl.1106.

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1106 Background: TNBC, although an aggressive breast cancer (BC) subtype, is highly immunogenic and the only BC subtype where the ICI pembrolizumab is approved. However, predictive biomarkers for pembrolizumab benefit are limited. The chemokines CXCL9 and CXCL10 attract CD8 + T cells into the tumor microenvironment (TME) and are associated with chemotherapy benefit, but little is known about their role in prediciting pembrolizumab benefit in TNBC. We investigated the association of CXCL9 , CXCL10 and their cognate receptor CXCR3 with TME and ICI efficacy. Methods: 3,038 TNBC samples were analy
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Neu, E., M. Michailov, U. Welscher, M. Schratz, and G. Weber. "On psychiatry and psychology." European Psychiatry 64, S1 (2021): S487. http://dx.doi.org/10.1192/j.eurpsy.2021.1302.

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IntroductionPsychiatry is fundamental interdisciplinary medical science with essential importance for enormous health-problems of humanity. Creation of integrative-psychiary in context of multidimensional&holistic medicine, founded by HIPPOCRATES-GALENUS-HUA T’UA-AVICENA-PARACELSUS is necessary to counteract disastrous human health-situation. Psychiatry needs new integrative therapy-models considering application of psychopharmacotherapy as well as practices of psycho-somatic (Th.v.UEXKÜLL) and somato-psychic theories (Y.IKEMI). Emperor AKIHITO during Opening-Ceremony of ICPM-2005-Kobe app
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41

Cheaib, Joseph G., Sunil H. Patel, Ridwan Alam, et al. "Racial differences in the natural history of small renal masses: A prospective registry study." Journal of Clinical Oncology 40, no. 6_suppl (2022): 295. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.295.

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295 Background: Patients with small renal masses (SRM) can be managed conservatively by active surveillance (AS) or active treatment. A subset of patients who elect for AS undergo delayed intervention, either due to progression or other factors. Using a large, prospective registry of patients with SRMs we characterize differences in SRM growth trajectories on AS and pathologic differences among resected SRMs between African Americans (AA) and Caucasians. Methods: We stratified patients enrolled in the prospective Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) registry by
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42

Mlinar, B., B. A. Biagi, and J. J. Enyeart. "Voltage-gated transient currents in bovine adrenal fasciculata cells. I. T-type Ca2+ current." Journal of General Physiology 102, no. 2 (1993): 217–37. http://dx.doi.org/10.1085/jgp.102.2.217.

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The whole cell version of the patch clamp technique was used to identify and characterize voltage-gated Ca2+ channels in enzymatically dissociated bovine adrenal zona fasciculata (AZF) cells. The great majority of cells (84 of 86) expressed only low voltage-activated, rapidly inactivating Ca2+ current with properties of T-type Ca2+ current described in other cells. Voltage-dependent activation of this current was fit by a Boltzmann function raised to an integer power of 4 with a midpoint at -17 mV. Independent estimates of the single channel gating charge obtained from the activation curve and
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43

Ohanian, Maro, Guillermo Garcia-Manero, Mark J. Levis, et al. "Sorafenib plus 5-azacytidine (AZA) in older untreated FLT3-ITD mutated AML." Journal of Clinical Oncology 35, no. 15_suppl (2017): 7029. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.7029.

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7029 Background: Sorafenib plus 5-azacytidine (AZA) is observed to be safe and effective in relapsed / refractory FLT3-ITD mutated acute myeloid leukemia (AML) patients (pts). Hypothesis: Combining sorafenib with AZA is safe and effective in older untreated FLT3-ITD mutated AML pts. Methods: Eligibility included: untreated FLT3-ITD mutated AML (≥10% mutation burden), age ≥60 yrs, adequate organ function, and ECOG performance status ≤ 2. The regimen was: AZA 75 mg/m2daily x 7 days and sorafenib 400 mg twice daily for 28 days. Results: 26 pts with untreated AML [median age 73 (61-86)] were enrol
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44

Tompkins, Alexandra G., Zane N. Gray, Rebekah E. Dadey, et al. "Radiomic analysis of patient and interorgan heterogeneity in response to immunotherapies and BRAF-targeted therapy in metastatic melanoma." Journal for ImmunoTherapy of Cancer 13, no. 2 (2025): e009568. https://doi.org/10.1136/jitc-2024-009568.

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Variability in treatment response may be attributable to organ-level heterogeneity in tumor lesions. Radiomic analysis of medical images can elucidate non-invasive biomarkers of clinical outcome. Organ-specific radiomic comparison across immunotherapies and targeted therapies has not been previously reported. We queried the UPMC Hillman Cancer Center registry for patients with metastatic melanoma (MEL) treated with immune checkpoint inhibitors (ICI) (anti-programmed cell death protein-1 (PD-1)/cytotoxic T-lymphocyte associated protein 4 (CTLA-4) (ipilimumab+nivolumab; I+N) or anti-PD-1 monothe
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45

Alam, Md Jahangir, Reaz Mobarak, Md Kamruzzaman, Abu Tayab, Probir Kumar Sarkar, and ABM Mahfuj Hassan Al Mamun. "Clinical Evaluation of Dengue Cases in Bangladesh Shishu Hospital & Institute." Dhaka Shishu (Children) Hospital Journal 39, no. 1 (2024): 9–17. https://doi.org/10.3329/dshj.v39i1.82435.

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Background: In Bangladesh, the re-emergence of dengue patients has created a huge burden on our children’s morbidity and mortality. A dengue outbreak erupted in Bangladesh in 2019, resulting in the highest number of deaths to date. Objective: To see the clinical and laboratory profile and hospital outcome of the children admitted in Bangladesh Shishu Hospital & Institute. Methods: A prospective observational study was conducted among the children having dengue infection at the inpatient department of Bangladesh Shishu Hospital & Institute from 1st August 2022 to 31st January 2023. A to
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46

Li, Zongru, Lu Yu, Li-Juan Hu, et al. "Sex Differences in Disease Characteristics and Outcome in Adults with Acute Myeloid Leukemia from China." Blood 144, Supplement 1 (2024): 6121. https://doi.org/10.1182/blood-2024-211874.

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Background There is a male predominance of acute myeloid leukemia (AML) incidence, but data on disease characteristics and survival by sex are conflicting, and most from western countries. Nowadays, there are limited data from Asian countries on sex disparities in disease characteristics and outcome in AML. Methods Data of consecutive newly-diagnosed elderly patients with AML at Peking University People's Hospital from January 2016 to June 2024 were reviewed. Clinical information, treatment regimens, cytogenetic and molecular data were obtained. Risk group classification was determined accordi
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47

Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud
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48

Rodríguez-Abreu, Delvys, Maximillian Hochmair, Byoung Chul Cho, et al. "Abstract CT253: Results from KEYNOTE-B99: Phase 2 study of first-line (1L) pembrolizumab (pembro) plus investigational agents and chemotherapy (chemo) for extensive-stage small-cell lung cancer (ES-SCLC)." Cancer Research 84, no. 7_Supplement (2024): CT253. http://dx.doi.org/10.1158/1538-7445.am2024-ct253.

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Abstract Background: ES-SCLC is an aggressive cancer with substantial mortality. Current 1L treatments include anti-PD-(L)1 + etoposide-platinum chemo (EP), but with minimal improvements in OS vs chemo. In the phase 3 KEYNOTE-604 study, pembro + EP significantly improved PFS (P = 0.0023) but not OS vs placebo + EP; ORR was also improved (71% vs 62%). We present data from the phase 2 KEYNOTE-B99 study (NCT04924101) of 1L pembro + investigational agents (MK-4830, anti-ILT4; boserolimab, anti-CD27; or lenvatinib), and EP for ES-SCLC. Methods: In this open-label platform study, patients (pts) were
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49

Božič, Luka. "Numbers, distribution and nest site characteristics of Jackdaw Corvus monedula in Slovenia and its conservation status." Acrocephalus 37, no. 170-171 (2016): 123–50. http://dx.doi.org/10.1515/acro-2016-0007.

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Abstract In 2008, a coordinated census of Jackdaw Corvus monedula was carried out to assess breeding population, distribution and nest site selection in Slovenia. Data collection continued for unsurveyed areas in the 2009-2011 period, including information on former colonies and threats. A total of 663-794 Jackdaw pairs were recorded at 86 sites, while total Slovene breeding population was estimated to be in the range of 700-900 pairs. Over one third of pairs were recorded in Central Slovenia, notably the largest city Ljubljana (20.8%), followed by almost a quarter in the Podravje region. Most
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50

Mollah, Mahabubur R., Dale J. Unwin, Glenn J. Fitzgerald, and Everard J. Edwards. "A CO2 Injection System Inside an Open-Top Chamber Enclosing Mature Field-Grown Grapevines: Design and Performance." Transactions of the ASABE 61, no. 4 (2018): 1231–39. http://dx.doi.org/10.13031/trans.12576.

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Abstract. Global mean temperature is likely to rise by more than 2°C by the end of the century and carbon dioxide concentration ([CO2]) is expected to increase from 408 µmol mol-1 in 2018 to 650 µmol mol-1 by 2060-2070. Previous studies and industry experience suggest that there has already been an effect of warmer temperatures on grapevine phenology; harvest dates have advanced and vintages have become shorter over the past 30 years in Australia. In addition, increasing [CO2] in the atmosphere will likely alter grapevine growth, development, and grape quality. Understanding the interactive ef
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