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Journal articles on the topic "669.208 3"
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Ling, K. S., H. Lin, M. L. Lewis Ivey, W. Zhang, and S. A. Miller. "First Report of ‘Candidatus Liberibacter solanacearum’ Naturally Infecting Tomatoes in the State of Mexico, Mexico." Plant Disease 95, no. 8 (2011): 1026. http://dx.doi.org/10.1094/pdis-05-11-0365.
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In January 2011, tomato (Solanum lycopersicum) plants exhibiting stunting, yellow mosaic, short, chlorotic leaves, aborted flowers, and reduced-size fruits, symptoms similar to those exhibited by plants infected by ‘Candidatus Liberibacter solanacearum’ (2), were observed in approximately 5% of tomato plants in greenhouses in Jocotitlan in the State of Mexico, Mexico. Occasional plant recovery was also observed. Tomato plants in this facility were previously shown to be infected by Mexican papita viroid (MPVd), Pepino mosaic virus (PepMV), and aster yellows phytoplasma. Eight symptomatic leaf samples (designated MX11-01 to MX11-08) were collected and screened against selected tomato viruses and pospiviroids by reverse transcription (RT)-PCR using purified plant RNA or for ‘Ca. L. solanacearum’ by PCR using purified plant DNA. As expected, both PepMV and MPVd were detected in these samples. However, two ‘Ca. L. solanacearum’-specific PCR products (1,168 and 669 bp) were also amplified in two samples (MX11-02 and MX11-05) using primers OA2 (2) and OI2c (1) or CL514F/CL514R (3), respectively. Each ‘Ca. L. solanacearum’-specific PCR product was gel purified with Geneclean (Q-Biogene, Carlsbad, CA) and cloned into pCR2.1 using TOPO TA cloning kit (Invitrogen, Carlsbad, CA) and sequenced (Functional Biosciences, Madison, WI). Sequences of 16S rRNA (1,168 bp) in both isolates (GenBank Accession Nos. JF811596 and JF811597) were identical. However, the 669-bp 50S rRNA sequences in these two isolates (GenBank Accession Nos. JF811598 and JF811599) contained two single nucleotide polymorphism (SNP) mutations. BLASTn searches showed that both 16S rRNA and 50S gene sequences in MX11-05 were identical to the ‘Ca. L. solanacearum’ previously identified on potato in Chihuahua (GenBank Accession Nos. FJ829811 and FJ829812) and Saltillo (GenBank Accession Nos. FJ498806 or FJ498807) in eastern Mexico. These ‘Ca. L. solanacearum’ isolates were recently classified as the “b” haplotype (4). Alignment analysis of the ‘Ca. L. solanacearum' 16S rRNA sequences also revealed the conserved SNP mutations (g.212T > G and g.581T > C) in MX11-02 and MX11-05 as previously identified for other “b” haplotype isolates (4). ‘Ca. L. solanacearum’ was first identified in greenhouse tomatoes in 2008 in New Zealand (2). It has also been identified in greenhouse and field tomatoes in the United States. ‘Ca. L. solanacearum’ was previously reported to infect field tomatoes in Sinaloa, Mexico (3), which was recently considered as the “a” haplotype (4). To our knowledge, this is the first report of ‘Ca. L. solanacearum’ naturally infecting tomatoes in Jocotitlan in the State of Mexico, Mexico. The greenhouse tomato ‘Ca. L. solanacearum’ may be transmitted from infected solanaceous plants by potato psyllids (Bactericera cockerelli), which were observed in this facility. References: (1) S. Jagoueix et al. Int. J. Syst. Bacteriol. 44:379, 1994. (2) L. W. Liefting et al. Plant Dis. 93:208, 2009. (3) J. E. Munyaneza et al. Plant Dis. 93:1076, 2009 (4) W. R. Nelson et al. Eur. J. Plant Pathol. 130:5, 2011.
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French-Monar, R. D., A. F. Patton, J. M. Douglas, et al. "First Report of “Candidatus Liberibacter solanacearum” on Field Tomatoes in the United States." Plant Disease 94, no. 4 (2010): 481. http://dx.doi.org/10.1094/pdis-94-4-0481a.
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In August 2008, 30% of tomato (Solanum lycopersicum) plants in plots in Lubbock County, Texas showed yellowing, lateral stem dieback, upward leaf curling, enlargement of stems, adventitious roots, and swollen nodes. Yellowing in leaves was similar to that seen with zebra chip disease (ZC) of potato that was confirmed in a potato field 112 km away in July 2008 and was associated with a ‘Candidatus Liberibacter’ species (1), similar to findings earlier in 2008 in New Zealand and California (2,3). Tissue from four symptomatic plants of cv. Spitfire and two of cv. Celebrity were collected and DNA was extracted from midribs and petioles with a FastDNA Spin Kit (Qbiogene, Inc., Carlsbad, CA,). PCR amplification was done with 16S rRNA gene primers OA2 and OI2c, which are specific for “Ca. Liberibacter solanacearum” from potato and tomato and amplify a 1.1-kb fragment of the 16S rRNA gene of this new species (1,3). Amplicons of 1.1 kb were obtained from all samples and these were sequenced in both orientations (McLab, San Francisco, CA). Sequences of the 16S rRNA gene were identical for both Spitfire and Celebrity and were submitted to the NCBI as GenBank Accession Nos. FJ939136 and FJ939137, respectively. On the basis of a BLAST search, sequence alignments revealed 99.9% identity with a new species of ‘Ca. Liberibacter’ from potato (EU884128 and EU884129) in Texas (1); 99.7% identity with the new species “Ca. Liberibacter solanacearum” described from potato and tomato (3) in New Zealand (EU849020 and EU834130, respectively) and from the potato psyllid Bactericera cockerelli in California (2) (EU812559, EU812556); 97% identity with ‘Ca L. asiaticus’ from citrus in Malaysia (EU224393) and 94% identity with both ‘Ca. L. africanus’ and ‘Ca. L. americanus’ from citrus (EU921620 and AY742824, respectively). A neighbor-joining cladogram constructed using the 16S rRNA gene fragments delineated four clusters corresponding to each species, and these sequences clustered with “Ca. L. solanacearum”. A second PCR analysis was conducted with the CL514F/CL514R primer pair, which amplifies a sequence from the rplJ and rplL ribosomal protein genes of “Ca. L. solanacearum”. The resulting 669-bp products were 100% identical to a sequence reported from tomato in Mexico (FJ498807). This sequence was submitted to NCBI (GU169328). ZC, a disease causing losses to the potato industry, is associated with a ‘Candidatus Liberibacter’ species (1–3) and was reported in Central America and Mexico in the 1990s, in Texas in 2000, and more recently in other states in the United States (4). In 2008, a “Ca. Liberibacter solanacearum” was detected on Capsicum annuum, S. betaceum, and Physalis peruviana in New Zealand (3). Several studies have shown that the potato psyllid, B. cockerelli, is a potential vector for this pathogen (2,4). To our knowledge, this is the first report of “Ca. Liberibacter solanacearum” in field tomatoes showing ZC-like foliar disease symptoms in the United States. References: (1). J. A. Abad et al. Plant Dis. 93:108, 2009 (2) A. K. Hansen et al. Appl. Environ. Microbiol. 74:5862, 2008. (3) L. W. Liefting et al. Plant Dis. 93:208, 2009. (4) G. A. Secor et al. Plant Dis. 93:574, 2009.
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Munyaneza, J. E., V. G. Sengoda, J. M. Crosslin, J. A. Garzón-Tiznado, and O. G. Cardenas-Valenzuela. "First Report of “Candidatus Liberibacter solanacearum” in Pepper Plants in México." Plant Disease 93, no. 10 (2009): 1076. http://dx.doi.org/10.1094/pdis-93-10-1076b.
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Bell pepper (Capsicum annuum) plants exhibiting symptoms that resembled those of potato psyllid (Bactericera cockerelli Sulc) damage and “Candidatus Liberibacter solanacearum” infection (2) were observed in a pepper field in La Cruz de Elota, Sinaloa, México in March 2009, with an infection rate of 1.5%. Plants exhibited chlorotic or pale green apical growth and leaf cupping, sharp tapering of the leaf apex, shortened internodes, and an overall stunting (2). Total DNA was extracted from the top whole leaf tissue of nine symptomatic and five asymptomatic pepper plants with cetyltrimethylammoniumbromide (CTAB) buffer (3,4). Seven and eight of the nine selected symptomatic pepper plants yielded the expected 1,168-bp 16S rDNA and the expected 669-bp rplJ/rplL ribosomal protein gene amplicons with the “Ca. L. solanacearum” specific OA2/OI2c and CL514F/CL514R primer pairs, respectively, indicating the presence of liberibacter (2,4). Nucleic acid from asymptomatic pepper plants yielded no products with these primers. Three amplicons generated from symptomatic pepper plants with each primer pair were cloned into pCRII-TOPO plasmid vectors (Invitrogen, Carlsbad, CA) and three clones of each amplicon were sequenced in both directions (ACGT, Inc., Wheeling, IL). BLAST analysis of the 16S rDNA consensus sequence (GenBank Accession No. FJ957896) showed 100% identity to 16S rDNA sequences of “Ca. L. solanacearum” amplified from Solanum betaceum (EU935004) and S. lycopersicum (EU834130) from New Zealand (2), and “Ca. L. psyllaurous” from potato psyllids (EU812559) (1). The ribosomal protein gene consensus sequence (GenBank Accession No. FJ957894) was 100% identical to the analogous rplJ and rplL “Ca. L. solanacearum” ribosomal protein gene sequence amplified from S. lycopersicum (EU834131) from New Zealand (2) and to ‘Ca. Liberibacter’ sp. sequence amplified from zebra chip-infected potato tubers from Lancaster, CA (FJ498803). To our knowledge, this is the first report of “Ca. L. solanacearum” associated with bell pepper in México. “Ca. L. solanacearum” was first reported in tomato and pepper plants in 2008 in New Zealand, where it has resulted in plant decline and significant yield loss, resulting in millions of dollars in losses to the commercial glasshouse tomato and pepper industry (2). Zebra chip, a new and emerging potato disease associated with ‘Ca. Liberibacter’ sp., was first identified in México in 1994, where it has caused significant economic damage, often leading to abandonment of entire potato fields (3,4). References: (1) A. K. Hansen et al. Appl. Environ. Microbiol. 74:5862, 2008. (2) L. W. Liefting et al. Plant Dis. 93:208, 2009. (3) J. E. Munyaneza et al. J. Econ. Entomol. 100:656, 2007. (4) J. E. Munyaneza et al. Plant Dis. 93:552, 2009.
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Yoon, S., C. Yoo, I. Park, et al. "Prognostic significance of preoperative serum tumor markers in the patients with curatively resected advanced gastric cancers." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15515-e15515. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15515.
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e15515 Background: We evaluated the prognostic significance of preoperative tumor markers, carcinoembryonic antigen (CEA), carbohydrate antigen 19–9 (CA19–9), and carbohydrate antigen 72–4 (CA72–4), in the patients with curatively resected advanced gastric cancers (AGC). Methods: Preoperative serum tumor markers were available for 667 patients who had been enrolled in a phase III trial of adjuvant chemotherapy (AMC0201). We compared the relapse free survival (RFS) and overall survival (OS) according to patient's pre-treatment clinical characteristics and serum tumor markers by using log rank test and Cox proportional hazard model. Results: Of total 667 patients, 3 year RFS rate and OS rate were 67.4% and 75.0%, respectively. Postoperative pathologic stage was II in 353 (52.9%), IIIA in 202 (30.3%), IIIB in 61 (9.1%), and IV (M0) in 51 (7.6%). CEA, CA19–9, CA72–4 were elevated pre-operatively in 64 of 665 patients (9.6%), 75 of 664 patients (11.3%), and 121 of 639 patients (18.9%), respectively. After the median follow-up of 38.4 months, 209 patients (31.3%) had recurrence, and 164 patients (24.6%) died. In the univariate analysis, location of tumor, type of surgery, Borrmann type, TNM stage, the elevation of CEA and CA72–4 level were significant prognostic factors for RFS and OS. In the multivariate analysis, serum CA72–4 was independent significant prognostic factor for RFS and OS as well as tumor location, Borrmann type, and stage Conclusions: Pre-operative serum CEA and CA72–4 levels were independent prognostic factors as well as clinical characteristics of pathologic stage, tumor location and Borrmann type in patients with curatively resected AGC. No significant financial relationships to disclose.
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Munyaneza, J. E., V. G. Sengoda, J. M. Crosslin, J. A. Garzón-Tiznado, and O. G. Cardenas-Valenzuela. "First Report of “Candidatus Liberibacter solanacearum” in Tomato Plants in México." Plant Disease 93, no. 10 (2009): 1076. http://dx.doi.org/10.1094/pdis-93-10-1076a.
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Tomato (Solanum lycopersicum) plants exhibiting symptoms resembling those of permanent yellowing disease (known in Mexico as “permanente del tomate”) that is commonly associated with phytoplasmas (1) were observed in tomato fields in Sinaloa, México in March 2009. Plant symptoms also resembled those caused by “Candidatus Liberibacter solanacearum” infection (2). Affected plants showed an overall chlorosis, severe stunting, leaf cupping, purple discoloration of veins, excessive branching of axillary shoots, and leaf scorching (1,2). Symptom incidence ranged from 18 to 40%. To investigate whether liberibacter is associated with permanent yellowing disease of tomato in México, eight symptomatic and five asymptomatic tomato plants were collected from two fields in La Cruz de Elota and Culiacán, Sinaloa. Total DNA was extracted from the top whole leaf tissue of symptomatic and asymptomatic plants with cetyltrimethylammoniumbromide (CTAB) buffer (3,4). DNA samples were tested by PCR using primer pairs OA2/OI2c and CL514F/CL514R, which amplify a sequence from the 16S rDNA and rplJ and rplL ribosomal protein genes, respectively, of “Ca. L. solanacearum” (2,4). The DNA samples were also tested for phytoplasmas with nested PCR using universal primer pairs P1/P7 and fU5/rU3 (3). DNA from five and four symptomatic plants yielded the expected 1,168-bp 16S rDNA and 669-bp rplJ/rplL amplicons, respectively, indicating the presence of liberibacter. Extracts from asymptomatic plants yielded no products with these primers. Amplicons generated from three symptomatic plants with each primer pair were cloned into pCRII-TOPO plasmid vectors (Invitrogen, Carlsbad, CA) and three clones of each of these amplicons were subsequently sequenced in both directions (ACGT, Inc., Wheeling, IL). BLAST analysis of the 16S rDNA consensus sequence (GenBank Accession No. FJ957897) showed 100% identity to 16S rDNA sequences of “Ca. L. solanacearum” amplified from S. betaceum (EU935004) and S. lycopersicum (EU834130) from New Zealand (2), and “Ca. L. psyllaurous” from potato psyllids (EU812559). The rplJ/rplL consensus sequence (GenBank Accession No. FJ957895) was 100% identical to the analogous rplJ and rplL “Ca. L. solanacearum” ribosomal protein gene sequence amplified from S. lycopersicum (EU834131) from New Zealand (2) and ‘Ca. Liberibacter’ sp. sequence amplified from zebra chip-infected potatoes from Lancaster, CA (FJ498803). No phytoplasmas were detected in the symptomatic tomato plants. To our knowledge, this is the first report of “Ca. L. solanacearum” associated with tomatoes in México. In 2008, this bacterium was detected in glasshouse tomatoes in New Zealand and caused millions of dollars in losses to the commercial glasshouse tomato industry (2). References: (1) R. L. Holguín-Peña et al. Plant Dis. 91:328, 2007. (2) L. W. Liefting et al. Plant Dis. 93:208, 2009. (3) J. E. Munyaneza et al. J. Econ. Entomol. 100:656, 2007. (4) J. E. Munyaneza et al. Plant Dis. 93:552, 2009.
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Begna, Kebede H., Amro Abdelatif, Susan M. Schwager, Curtis A. Hanson, Animesh Pardanani, and Ayalew Tefferi. "Busulfan for the Treatment of Myeloproliferative Neoplasms: The Mayo Clinic Experience." Blood 126, no. 23 (2015): 4078. http://dx.doi.org/10.1182/blood.v126.23.4078.4078.
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Abstract Background: The cytoreductive treatment options for myeloproliferative neoplasms, in those who have indications, may be limited to hydroxyurea and interferon. Busulfan has been reported to have some activity, but used less frequently in the management of BCR/ABL negative MPNs (Haanen CM et al Br J Cancer 1981; Brodsky American J of clinical oncology 1998). One study has shown significant JAK2V617F allele burden reduction with busulfan (Kuriakose ET et al; Haematologica 2013). Ruxolitinib was approved by the FDA for intermediate and high risk myelofibrosis; and as second line therapy for polycythemia vera in those who are intolerant or develop side effect to hydroxyurea. Objective: To assess the utility of busulfan, an old drug, in patients with myeloproliferative neoplasms who are intolerant to other forms of therapy. Methods: The mayo clinic data base from 1970 to 2014 was interrogated using the terms myeloproliferative disorder, polycythemia vera (PV), essential thrombocythemia (ET), myelofibrosis (MF) and busulfan. Patients' follow up information was collected till July 2015. Results : Seventy five patients with full demographic, diagnostic and therapeutic information were identified, and those included 37 patients with ET, 22 with PV, 12 with MF, and 4 with myeloproliferative neoplasms unclassifiable. The median age was 64 (range 31-91) years. After a median follow up of 17 years, 40 patients (53 %) died, and leukemic transformation was documented in 4 (5%). The median time for leukemic transformation was 86 months (12-229). 1. Essential Thrombocytopenia (n=37): Twenty nine (79%) were females, and the median (range) age was 67 (33-90) years. At diagnosis the median (range) hemoglobin (Hgb) (gm/dL), white blood cell count (WBC) (X109/L), and platelet count (X109/L) were 13.6 (9.8-16.9), 10.2 (5-231), 1113 (593-2062) respectively. After a median follow up time of 230 months, 15 patients (41%) died, and leukemic transformation was documented in 1 patient who was also treated with radioactive phosphorous (P32). Leukemic transformation was documented 230 months from date of diagnosis. Follow up complete blood count was available in 20 patients and the median (range) Hgb, WBC and platelet count was 12 (9.9-16), 7.4 (3.1-25), and 267 (126-573) respectively. 2. Polycythemia Vera (n=22): Fourteen (61%) were females, and the median (range) age was 64 (46-91) years. At diagnosis the median (range) Hgb, WBC, and platelet count were 17.5 (15.1-20.8), 11.5 (1.2-26.6), and 669 (185-2370) respectively. After a median follow up time of 188 months 13 (57%) patients died, and leukemic transformation was documented in 2 patients and one of them was given P32. Follow up complete blood count was available in 21 patients and their median (range) Hgb, WBC and platelet count was 12.9 (10-15.2), 7.2 (2.8-20), and 303 (124-833) respectively. 3. Myelofibrosis (Primary and Post-PV and Post-ET myelofibrosis) (n=12) : The median age was 52 (31-75) and 5 were females. The median Hgb, WBC, and platelet count were 13.6, 14.5, and 472. Six (50 %) patients did have splenomegaly (and 5 of them have splenic size reduction after busulfan), 3 underwent splenectomy, and 3 have no palpable spleen. At a median follow up of 208 months, and 39 months (range 78-401) from the start of busulfan, 10 (84%) patients died and no leukemic transformation was documented. Conclusion: Busulfan should be considered as alternative therapy in myeloproliferative neoplasms especially in ET and PV that are intolerant to other forms of cytoreductive therapy. Busulfan may be given as pulse therapy in controlling cell counts. Disclosures Off Label Use: Busulfan as alternative therapy in myeloproliferative neoplasms.
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Munyaneza, J. E., T. W. Fisher, V. G. Sengoda, S. F. Garczynski, A. Nissinen, and A. Lemmetty. "First Report of “Candidatus Liberibacter solanacearum” Associated with Psyllid-Affected Carrots in Europe." Plant Disease 94, no. 5 (2010): 639. http://dx.doi.org/10.1094/pdis-94-5-0639a.
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Carrot (Daucus carota) plants with symptoms resembling those of carrot psyllid (Trioza apicalis) damage (3,4) were observed in 14 commercial fields in southern Finland in August 2008; all cultivars grown were affected at approximately 5 to 35% symptomatic plants per field. T. apicalis, a pest of carrots in northern and central Europe, can cause up to 100% crop loss (3,4). Symptoms on affected plants included leaf curling, yellow and purple discoloration of leaves, stunted growth of shoots and roots, and proliferation of secondary roots (3,4). Given recent association of liberibacter with several annual crops affected by psyllids (1,2), an investigation on whether this bacterium is associated with symptoms of psyllid damage on carrots was conducted. Total DNA was extracted from petiole tissue of 20 symptomatic and 18 asymptomatic plants (cv. Maestro, Nanda, Nipomo, Nerac, and Fontana) sampled from 10 psyllid-infested fields in southern Finland, as well as 15 plants (cv. Primecut, Cheyenne, and Triple Play) grown from seed in an insect-free greenhouse, with the cetyltrimethylammoniumbromide (CTAB) method (2). DNA was also extracted from 10 carrot roots (cv. Nantura) of plants continuously exposed to field-collected carrot psyllid colonies in the laboratory. DNA samples were tested by PCR using primer pairs OA2/OI2c and CL514F/R to amplify a portion of 16S rDNA and rplJ/rplL ribosomal protein genes, respectively, of “Candidatus Liberibacter solanacearum” (1,2). A 1,168 bp 16S rDNA fragment was detected in DNA from 1 asymptomatic and 16 symptomatic plants and a 669 bp rplJ/rplL fragment was amplified from DNA from 19 symptomatic and 6 asymptomatic plants, indicating presence of liberibacter. DNA from all 10 root samples yielded similar amplicons with both primer pairs. DNA from all the greenhouse carrot plants yielded no amplicon. Amplicons from DNA from three petioles and three roots with each primer pair were cloned (pCR2.1-TOPO; Invitrogen, Carlsbad, CA) and three clones of each of the 12 amplicons were sequenced (MCLAB, San Francisco, CA). BLAST analysis of the 16S rDNA consensus sequences from petiole and root tissues (GenBank Accession Nos. GU373049 and GU373048, respectively) showed 99.9% identity to those of “Ca. L. solanacearum” amplified from Capsicum annuum (FJ957896) and Solanum lycopersicum (FJ957897) from Mexico, and “Ca. L. psyllaurous” from potato psyllids (EU812559). The rplJ/rplL consensus sequences from petioles and roots (GenBank Accession Nos. GU373051 and GU373050, respectively) were 97.9% identical to the analogous rplJ/rplL “Ca. L. solanacearum” ribosomal protein gene sequence from solanaceous crops in New Zealand (EU834131) and to “Ca. Liberibacter” sp. sequence from zebra chip-affected potatoes in California (FJ498803). To our knowledge, this is the first report of “Ca. L. solanacearum” associated with a nonsolanaceous species and the first report of this pathogen outside of North and Central America and New Zealand (1,2). References: (1) L. W. Liefting et al. Plant Dis. 93:208, 2009. (2) J. E. Munyaneza et al. Plant Dis. 93:552, 2009. (3) G. Nehlin et al. J. Chem. Ecol. 20:771, 1994. (4) A. Nissinen et al. Entomol. Exp. Appl. 125:277, 2007.
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Tahzima, R., M. Maes, E. H. Achbani, K. D. Swisher, J. E. Munyaneza, and K. De Jonghe. "First Report of ‘Candidatus Liberibacter solanacearum’ on Carrot in Africa." Plant Disease 98, no. 10 (2014): 1426. http://dx.doi.org/10.1094/pdis-05-14-0509-pdn.
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In March of 2014, carrot plants (Daucus carota L. var. Mascot) exhibiting symptoms of yellowing, purpling, and curling of leaves, proliferation of shoots, formation of hairy secondary roots, general stunting, and plant decline were observed in commercial fields in the Gharb region of Morocco. The symptoms resembled those caused by phytoplasmas, Spiroplasma citri, or ‘Candidatus Liberibacter solanacearum’ infection (1,2,3). About 30% of the plants in each field were symptomatic and plants were infested with unidentified psyllid nymphs; some psyllids are known vectors of ‘Ca. L. solanacearum.’ A total of 10 symptomatic and 2 asymptomatic plants were collected from three fields. Total DNA was extracted from petiole and root tissues of each of the carrots, using the CTAB buffer extraction method (3). The DNA samples were tested for phytoplasmas and spiroplasmas by PCR (3) but neither pathogen was detected in the samples. The DNA extracts were tested for ‘Ca. L. solanacearum’ by PCR using specific primer pairs OA2/OI2c, Lso adkF/R, and CL514F/R, to amplify a partial fragment of the 16S rDNA, the adenylate kinase gene, and rpIJ/rpIL50S rDNA ribosomal protein genes, respectively (1,2,5). DNA samples from all 10 symptomatic carrots yielded specific bands; 1,168 bp for the 16S rDNA fragment, 770 bp for the adk fragment, and 669 bp for rpIJ/rpIL, indicating the presence of ‘Ca. L. solanacearum.’ No ‘Ca. L. solanacearum’ was detected in asymptomatic plants. DNA amplicons of three plant samples (one plant/field) for each primer pair were directly sequenced (Macrogen Inc., Amsterdam). Sequencing results identified two distinct products for the OA2/OI2c primer pair (GenBank Accession Nos. KJ740159 and KJ740160), and BLAST analysis of the 16S rDNA amplicons showed 99 and 100% identity to ‘Ca. L. solanacearum’ (KF737346 and HQ454302, respectively). Two different sequences of the adk amplicon were obtained (KJ740162 and KJ740163), both of which were 98% identical to ‘Ca. L. solanacearum’ (CP002371). Sequencing results also identified two distinct products for the CL514F/R primer pair (KJ754506 and KJ754507), and BLAST analysis of the 50S rDNA ribosomal protein showed 99 and 100% identity to ‘Ca. L. solanacearum’ (KF357912 and HQ454321, respectively). The differences in our 16S and 50S rDNA sequences identified the presence of both ‘Ca. L. solanacearum’ haplotypes D and E (4). To our knowledge, this is the first report of the occurrence of ‘Ca. L. solanacearum’ in Morocco and Africa, suggesting a wider distribution of the bacterium in carrot crops in the Mediterranean region, including North Africa. ‘Ca. L. solanacearum’ has caused economic damages to carrot and celery crops in the Canary Islands and mainland Spain, France, Sweden, Norway, and Finland (3). This bacterium has also caused millions of dollars in losses to potato and several other solanaceous crops in the United States, Mexico, Central America, and New Zealand (1,2,5). Given the economic impact of ‘Ca. L. solanacearum’ on numerous important crops worldwide, it is imperative that preventive measures be taken to limit its spread. References: (1) L. W. Liefting et al. Plant Dis. 93:208, 2009. (2) J. E. Munyaneza et al. Plant Dis. 93:552, 2009. (3) J. E. Munyaneza et al. J. Plant Pathol. 93:697, 2011. (4) W. R. Nelson et al. Eur. J. Plant Pathol. 135:633, 2013. (5) A. Ravindran et al. Plant Dis. 95:1542, 2011.
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Golub, Olga, Galina Chekryga, and Oleg Motovilov. "Effect of Pollen Grains on the color of Honey from Melilotus officinalis (L.) Pall." Food Processing: Techniques and Technology 50, no. 4 (2020): 660–69. http://dx.doi.org/10.21603/2074-9414-2020-4-660-669.
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Introduction. According to the Federal State Statistics Service, the Siberian Federal district produced 8,464.06 tons of natural polyand monofloral honey in 2019. The share of the Altai region was 45.37%, Krasnoyarsk region – 7.8%, regions, Omsk – 7.0%, and Novosibirsk – 6.3%. The color of honey is one of the main identifying characteristics of products. It largely depends on the chemical composition of pollen grains of honey plants. Therefore, it is relevant to study the color of honey from the nectar of Melilotus officinalis (L.) Pall.
 Study objects and methods. The research featured honey samples produced from the nectar of Melilotus officinalis (L.) flowers. The honey was centrifuged and pumped in 2018 on the territory of the Altai region. The research involved standard methods, as well as an authentic method for determining the dominant pollen grains. The method was based on preserving the morphological features of pollen grains and did not change their spatial location, thus making it possible to determine their real content in honey.
 Results and discussion. The honey color was affected by pollen grains of honey-bearing plants: 1) Melilotus officinalis (L.) Pall. (84.89%) > Fagopyrum tataricum (L.) Gaertn. (1.0%) > Convolvulus arvensis L. (0.97%) > Origanum vulgare (L.) (0.97%) > Brassicaceae Burnett, nom. cons. (11.20%); 2) Melilotus officinalis (L.) Pall. (49.24%) > Dracocephalum nutans L. (7.58%) > Trifolium pratense L. (9.09%) > Brassicaceae Burnett, nom. cons. (18.18%) > Sonchus arvensis L. (2.07%); 3) Melilotus officinalis (L.) Pall. (54.05%) > Helianthus annuus L. (14.87%) > Linaria vulgaris Mill. (2.70%) > Arctium tomentosum Mill. (4.05%) > Trifolium repens L. (8.47%) > Brassicaceae Burnett, nom. cons. (10.81%). Color and nutritional value depended mostly on two factors. The first factor was represented by flavonoid compounds (leucoanthocyanins, catechins, flavonols, etc.) of pollen grains of Melilotus officinalis (L.) Pall., Brassicaceae Burnett, nom. cons., and Helianthus annuus L. Their contents were 5.2, 3.1, and 2.8%, respectively. The other factor involved carotenoids – Trifolium pratense L., Trifolium repens L. and Origanum vulgare (L.). Their contents were 50.0, 37.3, and 28.7 mg/kg, respectively.
 Conclusion. The research featured honey from the flowers of Melilotus officinalis (L.) Pall. obtained from the South of the Siberian Federal District. Its color proved to be one of the main sensory properties necessary for establishing the botanical profile of the plants. The color depended on the secondary pollen grains of honey plants, containing flavonoid compounds and carotenoids.
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Matsuoka, K., T. Fujii, R. Okamoto, et al. "P172 Clinical characteristics of newly diagnosed adult patients with Crohn’s disease in Japan: Interim analysis of Inception cohort registry study of patients with Crohn’s disease (iCREST-CD)." Journal of Crohn's and Colitis 15, Supplement_1 (2021): S246—S247. http://dx.doi.org/10.1093/ecco-jcc/jjab076.299.
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Abstract Background Information on patient demographics and disease characteristics at the time of Crohn’s disease (CD) diagnosis is considered to be an important aspect in the treatment and management of CD. However, reports on phenotypes, disease course, and treatment impact in newly diagnosed CD patients are limited. An interim analysis of a large registry study was conducted to analyze the clinical characteristics of CD patients at the time of diagnosis. Methods This prospective, non-interventional, observational registry study was conducted at 19 tertiary centers for CD treatment in Japan. Patients newly diagnosed with CD after Jun 2016 based on diagnostic criteria of the Ministry of Health, Labour & Welfare of Japan (age ≥16 years (yrs) at the time of informed consent with no prior exposure to biologics) were enrolled. Patient demographics, diagnostic procedures and categories, disease location and behavior of the lesions (based on Montreal classification) at time of CD diagnosis, were recorded. Results Patients were enrolled between Dec 17, 2018 and Jun 30, 2020, and a total of 672 eligible patients were analyzed; 93.3% (n=627) had definitive diagnosis and 68.2% were men. At the time of diagnosis, median age was 25 (range 13–86) yrs, and peak disease onset was 20–24 yrs. Diagnostic imaging examinations included conventional ileocolonoscopy (542/665, 81.5%), esophagogastroduodenoscopy (413/665, 62.1%), small bowel capsule endoscopy (74/665, 11.1%), balloon-assisted enteroscopy (149/665, 22.4%), CT enterography (74/665, 11.1%), and MR enterography (45/665, 6.8%). Most common disease location was L3 (ileocolonic), followed by, L1 (ileal) and L2 (colonic), 60.1%, 22.7%, and 16.3% of 664, respectively. Nonstricturing/nonpenetrating disease (B1) was most common behavior, followed by stricturing (B2) and penetrating disease (B3), 62.8%, 25.8% and 10.7% of 662, respectively; perianal disease was seen in 48.9% of 662. Interestingly, disease phenotype was different between the different age-at-onset groups (A1 [≤16 yrs], A2 [17–39 yrs], A3 [40–64 yrs], and elderly defined by age of onset ≥65 yrs; Figure 1–3). The male-to-female ratios were also different between these groups (A1: 1.7, A2: 2.6, A3: 1.3 and elderly: 1.3). Conclusion The study provides novel prospective insight on the clinical characteristics of newly diagnosed CD patients. Disease phenotype varied between patients <40 yrs and those ≥40 yrs of age in terms of male-to-female ratios, disease location/disease behavior/presence or absence of perianal lesion at the time of diagnosis. The ongoing prospective follow-up will provide additional insight.
Books on the topic "669.208 3"
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Jacobs, Klaus, Adelheid Kuhlmey, Stefan Greß, Jürgen Klauber, and Antje Schwinger, eds. Pflege-Report 2018. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-56822-4.
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Schwabe, Ulrich, Dieter Paffrath, Wolf-Dieter Ludwig, and Jürgen Klauber, eds. Arzneiverordnungs-Report 2018. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57386-0.
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Badura, Bernhard, Antje Ducki, Helmut Schröder, Joachim Klose, and Markus Meyer, eds. Fehlzeiten-Report 2018. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57388-4.
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Foret, Annie, Greg Kobele, and Sylvain Pogodalla, eds. Formal Grammar 2018. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-57784-4.
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Hermanns, Peter M., ed. EBM 2018 Kommentar. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-56488-2.
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Hermanns, Peter M., Godehard Diep, and Wolfgang Mattig, eds. GOÄ 2018 Kommentar, IGeL-Abrechnung. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-56494-3.
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Hermanns, Peter M., Enrico Schwartz, Thomas Tiling, Alexander Eisenkolb, and Karl-Heinz Hoffmann, eds. UV-GOÄ 2018 Kommentar. Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-662-56483-7.
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Hinsch, Martin. Guideline for EN 9100:2018. Springer Berlin Heidelberg, 2020. http://dx.doi.org/10.1007/978-3-662-61367-2.
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Pehlken, Alexandra, Matthias Kalverkamp, and Rikka Wittstock, eds. Cascade Use in Technologies 2018. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-57886-5.
Full textBook chapters on the topic "669.208 3"
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Reinhold, Siegfried, Franz Scheuring, and Bernd Zürn. "Marketing — Vertriebswege (Infoband S. 203–204)." In Lösungsheft Grundbildung für Kaufleute. Gabler Verlag, 1992. http://dx.doi.org/10.1007/978-3-663-07816-6_31.
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Prestel, Christiane. "Das ehemalige Palais Boisserée Hauptstraße 209 und das Haus Hauptstraße 207." In Die Gebäude der Universität Heidelberg. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-662-36931-9_21.
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Smid, Stefan, and Susanne Riedemann. "Kapitel 8: Nach § 208 Abs. 3 InsO zulässige prozessuale Instrumente der Masseverwertung." In Insolvenzverfahren bei Massearmut und Masseunzulänglichkeit. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-58974-8_8.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Excited Nuclear States for At-208 (Astatine)." In Supplement to I/25 A-G. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48747-1_633.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Neutron Resonance Parameters for Pb-208 (Lead)." In Supplement to Volume I/24. Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45603-3_324.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Excited Nuclear States for Rn-208 (Radon)." In Supplement to I/25 A-G. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48747-1_645.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Excited Nuclear States for Fr-208 (Francium)." In Supplement to I/25 A-G. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48747-1_659.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Excited Nuclear States for Tl-208 (Thallium)." In Supplement to I/25 A-G. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48747-1_556.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Excited Nuclear States for Pb-208 (Lead)." In Supplement to I/25 A-G. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48747-1_582.
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Sukhoruchkin, S. I., and Z. N. Soroko. "Excited Nuclear States for Bi-208 (Bismuth)." In Supplement to I/25 A-G. Springer Berlin Heidelberg, 2016. http://dx.doi.org/10.1007/978-3-662-48747-1_599.
Full textConference papers on the topic "669.208 3"
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Mosier, Bruce P., Robert W. Crocker, Judith L. Rognlien, and Kamlesh D. Patel. "High-Pressure Microhydraulic Actuator." In ASME 2003 International Mechanical Engineering Congress and Exposition. ASMEDC, 2003. http://dx.doi.org/10.1115/imece2003-55401.
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Actuation forces of 2.1 and 5.3 pounds (9.3 and 24 N) at velocities of 1 and 0.5 mm/s have been demonstrated with compact electrokinetic pumps producing 200 μL/min at 400 psi (2.8 MPa) and 100 μL/min at 1000 psi (6.9 MPa). This output compares favorably with electromechanical actuators (solenoid, piezoelectric, stepper motor) of similar size and is achieved silently and with no moving parts. Electrokinetic pump monoliths based on phase-separated porous methacrylate polymer monoliths and slurry-packed, sintered silica monoliths have been developed that can generate electrokinetic pressures of 3 psi/V (21 kPa/V) and 8 psi/V (6.9 kPa/V), respectively. Corresponding maximum power conversion efficiencies of 1% and 3% have been demonstrated in 10 mM TRIS-HCI at pH 8.5. Gas-bubble-free electrodes have been demonstrated to deliver 2 mA and seal to 1200 psi (8.3 MPa) for microhydraulic actuation.
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Hiroyama, Ryoji, Daijiro Inoue, Shingo Kameyama, et al. "High-power 200-mW 660-nm AlGaInP laser diodes with a low operating current." In 2003 International Conference on Solid State Devices and Materials. The Japan Society of Applied Physics, 2003. http://dx.doi.org/10.7567/ssdm.2003.a-4-3.
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Hsu, Keng-Fu, Yu-Ling Liang, Chin-Han Wu, and Neng-Yao Shih. "Abstract 639: Salt-inducible kinase 3 expression identifies long-term survivors of serous ovarian cancer." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-639.
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Yan, Yan, Dong Jixian, Tang Wei, and Feng Shiyuf. "Study on Heat Transfer Performance Affected by Structural Parameters of Multi-Channel Cylinder Dryer." In ASME 2016 5th International Conference on Micro/Nanoscale Heat and Mass Transfer. American Society of Mechanical Engineers, 2016. http://dx.doi.org/10.1115/mnhmt2016-6693.
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An approach to design multi-channel cylinder dryer was proposed. The heat transfer performance and flow characteristic under various structural parameters were analyzed. First, an experiment was designed and set up to measure the condensing heat transfer coefficient and the pressure drop in order to verify the applicability of the Cavallini’s correlation. Then, the relationship among the count of channels, aspect ratio, spacing ratio, width, height and hydraulic diameter of a channel was given. Finally, the correlation of condensing heat transfer and the homogeneous model were introduced in order to observe the heat transfer performance and flow characteristic of the multi-channel cylinder dryer affected by different structures. The study reveals that the structural parameters including count of channels, aspect ratio, spacing ratio of a channel dramatically influence the condensation heat transfer coefficient and frictional resistance of the steam. Based on the selected paper machine, it is suggested that the overall performance of the multi-channel cylinder dryer is best if the count of channels is 150–200, the aspect ratio is 1:3 and the spacing ratio is 1:1–1:3.
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Deligkas, Argyrios, Erez Karpas, Ron Lavi, and Rann Smorodinsky. "Traffic Light Scheduling, Value of Time, and Incentives." In Twenty-Seventh International Joint Conference on Artificial Intelligence {IJCAI-18}. International Joint Conferences on Artificial Intelligence Organization, 2018. http://dx.doi.org/10.24963/ijcai.2018/659.
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We study the intersection signalling control problem for cars with heterogeneous valuations of time (VoT). We are interested in a control algorithm that has some desirable properties: (1) it induces cars to report their VoT truthfully, (2) it minimizes the value of time lost for cars waiting at the intersection, and (3) it is computationally efficient. We obtain three main results: (1) We describe a computationally efficient heuristic forward search approach to solve the static problem. Simulation results show that this method is significantly faster than the dynamic-programming approach to solve the static problem (which is by itself polynomial time). We therefore believe that our algorithm can be commercially implemented. (2) We extend the solution of the static problem to the dynamic case. We couple our algorithm with a carefully designed payment scheme which yields an incentive compatible mechanism. In other words, it is the best interest of each car to truthfully report its VoT. (3) We describe simulation results that compare the social welfare obtained by our scheduling algorithm, as measured by the total value of waiting time, to the social welfare obtained by other intersection signalling control methods.
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Horák, Karel, Branislav Bošanský, and Krishnendu Chatterjee. "Goal-HSVI: Heuristic Search Value Iteration for Goal POMDPs." In Twenty-Seventh International Joint Conference on Artificial Intelligence {IJCAI-18}. International Joint Conferences on Artificial Intelligence Organization, 2018. http://dx.doi.org/10.24963/ijcai.2018/662.
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Partially observable Markov decision processes (POMDPs) are the standard models for planning under uncertainty with both finite and infinite horizon. Besides the well-known discounted-sum objective, indefinite-horizon objective (aka Goal-POMDPs) is another classical objective for POMDPs. In this case, given a set of target states and a positive cost for each transition, the optimization objective is to minimize the expected total cost until a target state is reached. In the literature, RTDP-Bel or heuristic search value iteration (HSVI) have been used for solving Goal-POMDPs. Neither of these algorithms has theoretical convergence guarantees, and HSVI may even fail to terminate its trials. We give the following contributions: (1) We discuss the challenges introduced in Goal-POMDPs and illustrate how they prevent the original HSVI from converging. (2) We present a novel algorithm inspired by HSVI, termed Goal-HSVI, and show that our algorithm has convergence guarantees. (3) We show that Goal-HSVI outperforms RTDP-Bel on a set of well-known examples.
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Sarker, Sunandita, Yiannis S. Chatzizisis, Srivatsan Kidambi, and Benjamin S. Terry. "Design and Development of a Novel Drug Delivery Catheter for Atherosclerosis." In 2018 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/dmd2018-6869.
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Atherosclerosis is a chronic progressive cardiovascular disease that results from plaque formation in the arteries. It is one of the leading causes of death and loss of healthy life in modern world. Atherosclerosis lesions consist of sub-endothelial accumulations of cholesterol and inflammatory cells [1]. However, not all lesions progress to the final stage to cause catastrophic ischemic cardiovascular events [2]. Early identification and treatment of high-risk plaques before they rupture, and precipitate adverse events constitutes a major challenge in cardiology today. Numerous investigations have confirmed that atherosclerosis is an inflammatory disease [3] [4] [5]. This confirmation has opened the treatment of this disease to many novel anti-inflammatory therapeutics. The use of nanoparticle-nanomedicines has gained popularity over recent years. Initially approved as anticancer treatment therapeutics [6], nanomedicine also holds promise for anti-inflammatory treatment, personalized medicine, target-specific treatment, and imaging of atherosclerotic disease [7]. The primary aim of this collaborative work is to develop and validate a novel strategy for catheter-directed local treatment of high-risk plaque using anti-inflammatory nanoparticles. Preselected drugs with the highest anti-inflammatory efficacy will be incorporated into a novel liposome nanocarrier, and delivered in-vivo through a specially designed catheter to high-risk atherosclerotic plaques. The catheter has specially designed perfusion pores that inject drug into the blood stream in such a controlled manner that the streamlines carry the nanoparticles to the stenotic arterial wall. Once the particles make it to the arterial wall, they can be absorbed into the inflamed tissue. In this paper, we discuss the design and development of an atraumatic drug delivery catheter for the administration of lipid nanoparticles.
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Saeidpourazar, Reza, and Nader Jalili. "Forced-Controlled Nanomanipulation Utilizing Nano-Robotic Manipulator and Nanomechanical Cantilever." In ASME 2008 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. ASMEDC, 2008. http://dx.doi.org/10.1115/smasis2008-629.
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This paper presents forced-controlled nanomanipulation utilizing nano-robotic manipulator and nanomechanical cantilever. A three degree of freedom (3 DOF) nanomanipulator with revolute revolute prismatic (RRP) actuator structure, named here MM3A®, can be utilized for a variety of nanomanipulation tasks. Previous publications of the authors present the mathematical modeling and robust control of manipulator’s tip using fused visual servoing and force sensor feedbacks. Due to lack of position and velocity feedbacks in MM3A® nanomanipulator, a fused vision/force feedback robust controller has been recently designed by the authors. Previous publications of the authors present the optimal utilization of the visual servoing and force sensor feedbacks for use in the nanomanipulation tasks. More specifically, the visual servoing and force feedback structures are investigated through extensive simulations in order to reveal issues in practical implementation. In modeling the force sensing module of the designed fused feedback controller, previous publications of the authors present a closed-form distributed-parameters based modeling framework for piezoresistive Nanomechanical Cantilever (NMC)-based force sensors used in a variety of cantilever-based nanomanipulation actions. Current modeling practices call for a simple lumped-parameters framework rather than modeling the piezoresistive NMC itself. Due to the widespread applications of such NMCs in nanoscale force sensing or non-contact atomic force microscopy with nano-Newton to pico-Newton force measurement requirements, precise modeling of the piezoresistive microcantilevers is essential. Instead of the previously used lumped-parameters modeling, a distributed-parameters modeling framework is proposed and developed in previous publications of the authors to arrive at the most complete model of the piezoresistive NMC including tip-mass, tip-force and base movement considerations. Here, experimental results are presented to demonstrate the accuracy of the proposed distributed-parameters model when compared with the previously reported lumped-parameters modeling approach. It is shown that by utilizing the distributed-parameters model rather than lumped-parameters approach and by predicting the exact motion of each point on the NMC, the precision of the piezoresistive NMC’s model is significantly enhanced. Such novel modeling framework could pave the pathway towards nanomechanical cantilever-based manipulation and positioning as detailed in the second part.
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Woods, A. I., and M. A. Lazzari. "ASPIRIN FAILURE TO INHIBIT THE RELEASE OF PLASMINOGEN ACTIVATORS-INHIBITORS BY HUMAN PLATELETS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643126.
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Platelet-PA-Inhibitors can be released by thrombin, Col laaen( Col) and others.If they are physiologically important,inhibition of their release might facilitate thrombolysis.Intrinsic PA were tested in euclobulins (eug)of PPP and PPP+Washed platelets(WP) ,with and without aspirinf ASA) .treated with UK,SK and Col(20 atfd l2uo/ml) Results(mm2)were:euaPPP:232+78;+3×106WP/ul:217+71;+10%7ul:188+/5 +2×106MP/ul: 157+69:With UK:eugPPP:283+76;+3×l0517P/ul :234+69;+106 WP/ul :172+55;+2×l(PWP/ul :154+48; With SK:euoPPP:303+99;+3×l05WP/ul 252+65;+1067P/ul:203+68;+2×106UP/ul: 174+85;Wi th Col (20ug/ml) :eur PPP:234+97;+3×105WP/ul:160+63;+106WP/ul:141+73;+2×l06WP/ul:129+81; +2×106WP/ul+ASA: 105+31;Wi th Col uc/ml) :euaPPP:230+56;+3×l05NP/ul: 160+52;+106WP/ul:139+44;+2×106wp/ul:126+21;+2×106WP/ul+ASA:118+28. EugPPP+l/P showed lower lysis area.Col induced more decrease of lysis area in euc with WP.ASA did not modify this effect.UK and SK produced higher lysis area only in euoPPP.No difference was observed between high and low doses of Col-effect upon WP.Combined treatment of eucPPP+WP+Col, with UK and SK showed:(mm2):UK-treated eugPPP+2×106WP/ul+Col(29ug/ml):134+25;+ASA and Col(20ug/ml):115+65;+Col(2uc/ml):157+50;+ASA and Col(2uo/ml):133+49; SK-treated eupPPP+2×106WP/ul:+Col(20uo/ml):144+49;+ASA and Col(20ug/ml):128+ 60;+Co1(2ug/ml):173+66;+ASA and Col(2ug/ml):142+36.Col (20ug/ml) produced slight lower lysis area of UK and SK-treated eugPPP+WP. (p:ns). ASA did not modify this effect.Col (2uc/ml) did not produce changes in lysis area of UK and SK-treated eupPPP +WP. ASA produced slight lower lysis area(p:ns).Conclusion: high dosis of Col could release anti UK,anti SK and intrinsic PA-inhibitors from platelets;low dosis of Col could only release fntrinsic PA-inhibi tors. It suggests that anti UK and anti SK release might be triggered by stronger stimuli than intrinsic PA inhibitors.ASA could not inhibit any inhibitors release.We must consider that PA-inhibi tors could be released by different metabolic pathways other than cyclooxygenase pathway.
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Бородихин, А. Ю., та А. А. Юдин. "Из истории формирования библиотеки В. Н. Перетца и В. П. Адриановой-Перетц". У Одиннадцатые Макушинские чтения. ГПНТБ СО РАН, 2018. http://dx.doi.org/10.20913/2618-6691-2018-3-25-33.
Full textReports on the topic "669.208 3"
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Olsen, Laurie, Kathryn Lindholm-Leary, Magaly Lavadenz, Elvira Armas, and Franca Dell'Olio. Pursuing Regional Opportunities for Mentoring, Innovation, and Success for English Learners (PROMISE) Initiative: A Three-Year Pilot Study Research Monograph. PROMISE INITIATIVE, 2010. http://dx.doi.org/10.15365/ceel.seal2010.
Full textAbstract:
The Pursuing Regional Opportunities for Mentoring, Innovation, and Success for English Learners (PROMISE) Initiative Research Monograph is comprised of four sub-studies that took place between 2006 and 2009 to examine the effectiveness of the PROMISE Initiative across six implementing counties. Beginning in 2002, the superintendents of the six Southern California County Offices of Education collaborated to examine the pattern of the alarmingly low academic performance of English learners (EL) across Los Angeles, Orange, San Bernardino, San Diego, Riverside, and Ventura. Together, these six counties serve over one million EL students, more than 66% of the total EL population in the state of California, and close to 20% of the EL population in the nation. Data were compiled for the six counties, research on effective programs for ELs was shared, and a common vision for the success of ELs began to emerge. Out of this effort, the PROMISE Initiative was created to uphold a critical vision that ensured that ELs achieved and sustained high levels of proficiency, high levels of academic achievement, sociocultural and multicultural competency, preparation for successful transition to higher education, successful preparation as a 21st century global citizen, and high levels of motivation, confidence, and self-assurance. This report is organized into six chapters: an introductory chapter, four chapters of related studies, and a summary chapter. The four studies were framed around four areas of inquiry: 1) What is the PROMISE model? 2) What does classroom implementation of the PROMISE model look like? 3) What leadership skills do principals at PROMISE schools need to lead transformative education for ELs? 4) What impact did PROMISE have on student learning and participation? Key findings indicate that the PROMISE Initiative: • resulted in positive change for ELs at all levels including achievement gains and narrowing of the gap between ELs and non-ELs • increased use of research-based classroom practices • refined and strengthened plans for ELs at the district-level, and • demonstrated potential to enable infrastructure, partnerships, and communities of practice within and across the six school districts involved. The final chapter of the report provides implications for school reform for improving EL outcomes including bolstering EL expertise in school reform efforts, implementing sustained and in-depth professional development, monitoring and supporting long-term reform efforts, and establishing partnerships and networks to develop, research and disseminate efforts.
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Olsen, Laurie, Kathryn Lindholm-Leary, Magaly Lavadenz, Elvira Armas, and Franca Dell'Olio. Pursuing Regional Opportunities for Mentoring, Innovation, and Success for English Learners (PROMISE) Initiative: A Three-Year Pilot Study Research Monograph. PROMISE INITIATIVE, 2010. http://dx.doi.org/10.15365/ceel.promise2010.
Full textAbstract:
The Pursuing Regional Opportunities for Mentoring, Innovation, and Success for English Learners (PROMISE) Initiative Research Monograph is comprised of four sub-studies that took place between 2006 and 2009 to examine the effectiveness of the PROMISE Initiative across six implementing counties. Beginning in 2002, the superintendents of the six Southern California County Offices of Education collaborated to examine the pattern of the alarmingly low academic performance of English learners (EL) across Los Angeles, Orange, San Bernardino, San Diego, Riverside, and Ventura. Together, these six counties serve over one million EL students, more than 66% of the total EL population in the state of California, and close to 20% of the EL population in the nation. Data were compiled for the six counties, research on effective programs for ELs was shared, and a common vision for the success of ELs began to emerge. Out of this effort, the PROMISE Initiative was created to uphold a critical vision that ensured that ELs achieved and sustained high levels of proficiency, high levels of academic achievement, sociocultural and multicultural competency, preparation for successful transition to higher education, successful preparation as a 21st century global citizen, and high levels of motivation, confidence, and self-assurance. This report is organized into six chapters: an introductory chapter, four chapters of related studies, and a summary chapter. The four studies were framed around four areas of inquiry: 1) What is the PROMISE model? 2) What does classroom implementation of the PROMISE model look like? 3) What leadership skills do principals at PROMISE schools need to lead transformative education for ELs? 4) What impact did PROMISE have on student learning and participation? Key findings indicate that the PROMISE Initiative: • resulted in positive change for ELs at all levels including achievement gains and narrowing of the gap between ELs and non-ELs • increased use of research-based classroom practices • refined and strengthened plans for ELs at the district-level, and • demonstrated potential to enable infrastructure, partnerships, and communities of practice within and across the six school districts involved. The final chapter of the report provides implications for school reform for improving EL outcomes including bolstering EL expertise in school reform efforts, implementing sustained and in-depth professional development, monitoring and supporting long-term reform efforts, and establishing partnerships and networks to develop, research and disseminate efforts.
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African Open Science Platform Part 1: Landscape Study. Academy of Science of South Africa (ASSAf), 2019. http://dx.doi.org/10.17159/assaf.2019/0047.
Full textAbstract:
This report maps the African landscape of Open Science – with a focus on Open Data as a sub-set of Open Science. Data to inform the landscape study were collected through a variety of methods, including surveys, desk research, engagement with a community of practice, networking with stakeholders, participation in conferences, case study presentations, and workshops hosted. Although the majority of African countries (35 of 54) demonstrates commitment to science through its investment in research and development (R&D), academies of science, ministries of science and technology, policies, recognition of research, and participation in the Science Granting Councils Initiative (SGCI), the following countries demonstrate the highest commitment and political willingness to invest in science: Botswana, Ethiopia, Kenya, Senegal, South Africa, Tanzania, and Uganda. In addition to existing policies in Science, Technology and Innovation (STI), the following countries have made progress towards Open Data policies: Botswana, Kenya, Madagascar, Mauritius, South Africa and Uganda. Only two African countries (Kenya and South Africa) at this stage contribute 0.8% of its GDP (Gross Domestic Product) to R&D (Research and Development), which is the closest to the AU’s (African Union’s) suggested 1%. Countries such as Lesotho and Madagascar ranked as 0%, while the R&D expenditure for 24 African countries is unknown. In addition to this, science globally has become fully dependent on stable ICT (Information and Communication Technologies) infrastructure, which includes connectivity/bandwidth, high performance computing facilities and data services. This is especially applicable since countries globally are finding themselves in the midst of the 4th Industrial Revolution (4IR), which is not only “about” data, but which “is” data. According to an article1 by Alan Marcus (2015) (Senior Director, Head of Information Technology and Telecommunications Industries, World Economic Forum), “At its core, data represents a post-industrial opportunity. Its uses have unprecedented complexity, velocity and global reach. As digital communications become ubiquitous, data will rule in a world where nearly everyone and everything is connected in real time. That will require a highly reliable, secure and available infrastructure at its core, and innovation at the edge.” Every industry is affected as part of this revolution – also science. An important component of the digital transformation is “trust” – people must be able to trust that governments and all other industries (including the science sector), adequately handle and protect their data. This requires accountability on a global level, and digital industries must embrace the change and go for a higher standard of protection. “This will reassure consumers and citizens, benefitting the whole digital economy”, says Marcus. A stable and secure information and communication technologies (ICT) infrastructure – currently provided by the National Research and Education Networks (NRENs) – is key to advance collaboration in science. The AfricaConnect2 project (AfricaConnect (2012–2014) and AfricaConnect2 (2016–2018)) through establishing connectivity between National Research and Education Networks (NRENs), is planning to roll out AfricaConnect3 by the end of 2019. The concern however is that selected African governments (with the exception of a few countries such as South Africa, Mozambique, Ethiopia and others) have low awareness of the impact the Internet has today on all societal levels, how much ICT (and the 4th Industrial Revolution) have affected research, and the added value an NREN can bring to higher education and research in addressing the respective needs, which is far more complex than simply providing connectivity. Apart from more commitment and investment in R&D, African governments – to become and remain part of the 4th Industrial Revolution – have no option other than to acknowledge and commit to the role NRENs play in advancing science towards addressing the SDG (Sustainable Development Goals). For successful collaboration and direction, it is fundamental that policies within one country are aligned with one another. Alignment on continental level is crucial for the future Pan-African African Open Science Platform to be successful. Both the HIPSSA ((Harmonization of ICT Policies in Sub-Saharan Africa)3 project and WATRA (the West Africa Telecommunications Regulators Assembly)4, have made progress towards the regulation of the telecom sector, and in particular of bottlenecks which curb the development of competition among ISPs. A study under HIPSSA identified potential bottlenecks in access at an affordable price to the international capacity of submarine cables and suggested means and tools used by regulators to remedy them. Work on the recommended measures and making them operational continues in collaboration with WATRA. In addition to sufficient bandwidth and connectivity, high-performance computing facilities and services in support of data sharing are also required. The South African National Integrated Cyberinfrastructure System5 (NICIS) has made great progress in planning and setting up a cyberinfrastructure ecosystem in support of collaborative science and data sharing. The regional Southern African Development Community6 (SADC) Cyber-infrastructure Framework provides a valuable roadmap towards high-speed Internet, developing human capacity and skills in ICT technologies, high- performance computing and more. The following countries have been identified as having high-performance computing facilities, some as a result of the Square Kilometre Array7 (SKA) partnership: Botswana, Ghana, Kenya, Madagascar, Mozambique, Mauritius, Namibia, South Africa, Tunisia, and Zambia. More and more NRENs – especially the Level 6 NRENs 8 (Algeria, Egypt, Kenya, South Africa, and recently Zambia) – are exploring offering additional services; also in support of data sharing and transfer. The following NRENs already allow for running data-intensive applications and sharing of high-end computing assets, bio-modelling and computation on high-performance/ supercomputers: KENET (Kenya), TENET (South Africa), RENU (Uganda), ZAMREN (Zambia), EUN (Egypt) and ARN (Algeria). Fifteen higher education training institutions from eight African countries (Botswana, Benin, Kenya, Nigeria, Rwanda, South Africa, Sudan, and Tanzania) have been identified as offering formal courses on data science. In addition to formal degrees, a number of international short courses have been developed and free international online courses are also available as an option to build capacity and integrate as part of curricula. The small number of higher education or research intensive institutions offering data science is however insufficient, and there is a desperate need for more training in data science. The CODATA-RDA Schools of Research Data Science aim at addressing the continental need for foundational data skills across all disciplines, along with training conducted by The Carpentries 9 programme (specifically Data Carpentry 10 ). Thus far, CODATA-RDA schools in collaboration with AOSP, integrating content from Data Carpentry, were presented in Rwanda (in 2018), and during17-29 June 2019, in Ethiopia. Awareness regarding Open Science (including Open Data) is evident through the 12 Open Science-related Open Access/Open Data/Open Science declarations and agreements endorsed or signed by African governments; 200 Open Access journals from Africa registered on the Directory of Open Access Journals (DOAJ); 174 Open Access institutional research repositories registered on openDOAR (Directory of Open Access Repositories); 33 Open Access/Open Science policies registered on ROARMAP (Registry of Open Access Repository Mandates and Policies); 24 data repositories registered with the Registry of Data Repositories (re3data.org) (although the pilot project identified 66 research data repositories); and one data repository assigned the CoreTrustSeal. Although this is a start, far more needs to be done to align African data curation and research practices with global standards. Funding to conduct research remains a challenge. African researchers mostly fund their own research, and there are little incentives for them to make their research and accompanying data sets openly accessible. Funding and peer recognition, along with an enabling research environment conducive for research, are regarded as major incentives. The landscape report concludes with a number of concerns towards sharing research data openly, as well as challenges in terms of Open Data policy, ICT infrastructure supportive of data sharing, capacity building, lack of skills, and the need for incentives. Although great progress has been made in terms of Open Science and Open Data practices, more awareness needs to be created and further advocacy efforts are required for buy-in from African governments. A federated African Open Science Platform (AOSP) will not only encourage more collaboration among researchers in addressing the SDGs, but it will also benefit the many stakeholders identified as part of the pilot phase. The time is now, for governments in Africa, to acknowledge the important role of science in general, but specifically Open Science and Open Data, through developing and aligning the relevant policies, investing in an ICT infrastructure conducive for data sharing through committing funding to making NRENs financially sustainable, incentivising open research practices by scientists, and creating opportunities for more scientists and stakeholders across all disciplines to be trained in data management.