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Journal articles on the topic '7-bis(trifluoromethyl)pyrazolo[1'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Barlin, GB, and WL Tan. "Potential Antimalarials. V. 4-(7′-Trifluoromethylquinolin-4′-Ylamino)Phenols, 4-[2′,7′ and 2',8′-Bis(Trifluoromethyl)Quinolin-4′-Ylamino]Phenols and N4-Substituted 2,7-(and 2,8-)Bis(Trifluoromethyl)-Quinolin-4-Amines." Australian Journal of Chemistry 38, no. 12 (1985): 1827. http://dx.doi.org/10.1071/ch9851827.

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Mono- and di-Mannich bases of 4-(7′-trifluoromethylquinolin-4′- ylamino )phenol and its 2′,7′- and 2′,8′-bis( trifluoromethyl ) analogues, for example 2,6-bis(piperidin-1′-ylmethyl)-4-(7′-trifluoromethyl- quinolin-4′-ylamino)phenol, have been prepared. The Mannich bases from 4-(7′-trifluoromethyl-quinolin-4′-ylamino)phenol showed significant antimalarial activity when injected intraperitoneally in a single dose of 100 mg/kg to mice infected with Plasmodium vinckei vinckei ; those from its 2′,7′- and 2′,8′-bis( trifluoromethyl ) analogues did not show appreciable activity. Some N4-substituted 2

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2

Tarlton, Michael L., Steven P. Kelley, and Justin R. Walensky. "Crystal structures of metallocene complexes with uranium–germanium bonds." Acta Crystallographica Section E Crystallographic Communications 77, no. 12 (2021): 1258–62. http://dx.doi.org/10.1107/s2056989021011269.

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The first structural examples of complexes with uranium–germanium bonds are presented, namely, bis[3,5-bis(trifluoromethyl)phenyl-2κC 1](hydrido-2κH)(iodido-1κI)bis[1,1(η5)-pentamethylcyclopentadienyl]germaniumuranium(Ge—U), [GeU(C10H15)2(C8H3F6)2HI], and bis[3,5-bis(trifluoromethyl)phenyl-2κC 1](fluorido-1κI)(hydrido-2κH)bis[1,1(η5)-pentamethylcyclopentadienyl]germaniumuranium(Ge—U), [GeU(C10H15)2(C8H3F6)2FH]. The two complexes both have a long U—Ge bond [distances of 3.0428 (7) and 3.0524 (7) Å].

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3

Li, Ning, Xianyong Bai, Lianshuang Zhang, and Yun Hou. "Synthesis, crystal structures and anti-inflammatory activity of four 3,5-bis(arylidene)-N-benzenesulfonyl-4-piperidone derivatives." Acta Crystallographica Section C Structural Chemistry 74, no. 10 (2018): 1171–79. http://dx.doi.org/10.1107/s2053229618013232.

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3,5-Bis(arylidene)-4-piperidone (BAP) derivatives display good antitumour and anti-inflammatory activities because of their double α,β-unsaturated ketone structural characteristics. If N-benzenesulfonyl substituents are introduced into BAPs, the configuration of the BAPs would change significantly and their anti-inflammatory activities should improve. Four N-benzenesulfonyl BAPs, namely (3E,5E)-1-(4-methylbenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)benzylidene]piperidin-4-one dichloromethane monosolvate, C28H21F6NO3S·CH2Cl2, (4), (3E,5E)-1-(4-fluorobenzenesulfonyl)-3,5-bis[4-(trifluoromethyl)b

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4

Burger, Klaus, Norbert Sewald, Erasmus Huber, and Ralph Ottlinger. "Reaktionen 4,4-Bis(trifluormethyl)-substituierter Heterodiene mit Alkinen / Reactions of 4,4-Bis(trifluoromethyl) Substituted Heterodienes with Alkynes." Zeitschrift für Naturforschung B 44, no. 10 (1989): 1298–312. http://dx.doi.org/10.1515/znb-1989-1026.

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4,4-Bis(trifluoromethyl) substituted 1-oxa-3-azabuta-1,3-dienes (1) and alkynes react to give open-chain trifluoromethyl substituted N-propargylic amides (4), 4H-1,3-oxazines (5) and 2-oxazolines (6, 7), respectively. The selectivity of the reaction can be controlled effectively by the reaction conditions used.

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5

Zang, Kai-Kai, Xiao Xiao, Li-Qiang Chen, et al. "Distinct Function of Estrogen Receptors in the Rodent Anterior Cingulate Cortex in Pain-related Aversion." Anesthesiology 133, no. 1 (2020): 165–84. http://dx.doi.org/10.1097/aln.0000000000003324.

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Background Brain-derived estrogen is implicated in pain-related aversion; however, which estrogen receptors mediate this effect remains unclear. This study hypothesized that the different estrogen receptors in the rostral anterior cingulate cortex play distinct roles in pain-related aversion. Methods Formalin-induced conditioned place avoidance and place escape/avoidance paradigms were used to evaluate pain-related aversion in rodents. Immunohistochemistry and Western blotting were used to detect estrogen receptor expression. Patch-clamp recordings were used to examine N-methyl-d-aspartate–med

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6

Voeltera, Wolfgang, Mustafa M. El-Abadelahb, Salim S. Sabrib, and Monther A. Khanfar. "Synthesis and Properties of Biagra . A 5-(2,3-Dihydro-7-benzofuryl) Analog of Viagra®." Zeitschrift für Naturforschung B 54, no. 11 (1999): 1469–73. http://dx.doi.org/10.1515/znb-1999-1121.

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The synthesis and spectral properties (IR, MS, NMR) of a substituted 5-(2,3-dihydro-7- benzofuryl)pyrazolo[4,3-d]pyrimidin-7-one (2), an analog of Viagra® (1), are described. The generally applicable route involves interaction of 2,3-dihydro-7-benzofuranoyl chloride (3) with 4-amino-l-methyl-3-propyl-5-pyrazolecarboxamide (4), and the resulting bis-amide (5) is cyclized to the corresponding substituted pyrazolo[4,3-d]pyrimidin-7-one (6). Chlorosulfonylation of 6, followed by treatment with 1-methylpiperazine, furnished the title compound 2 (named Biagra). Preliminary experiments “associated wi

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7

Thokchom, Herojit S., Anita D. Nongmeikapam, and Warjeet S. Laitonjam. "Synthesis of fused pyrazolo-, isoxazolo-, pyrimido-, and pyridopyrimidines." Canadian Journal of Chemistry 83, no. 8 (2005): 1056–62. http://dx.doi.org/10.1139/v05-054.

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A systematic study of the synthesis of the 5,7-diaryl-4-oxo-pyrazolo[3,4-d]pyrimidin-6-thiones (3), 2-phenyl-5,7-bis(2′-methylphenyl)-4-oxo-pyrazolo[3,4-d]pyrimidin-6-thiones (4b), 2(3H)-3-phenyl-5,7-diaryl-4-oxo-pyrazolo[3,4-d]pyrimidin-6-thiones (5), 5,7-diaryl-4-oxo-isoxazolo[5,4-d]pyrimidin-6-thiones (7), 3,5,7-triaryl-2,3-dihydro-4-oxo-isoxazalo[5,4-d]pyrimidin-6-thiones (8), 2-amino-6,8-diaryl-5-oxo-pyrimido[4,5-d]pyrimidin-7-thiones (9), 3,4-dihydro-2-amino-4-phenyl-6,8-diaryl-5-oxo-pyrimido[4,5-d]pyrimidin-7-thiones (10), 3-cyano-6,8-diaryl-2,5-dioxo-pyrido[2,3-d]pyrimidin-7-thiones (1

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8

Blanch, Rodney J., and Curt Wentrup. "Trifluoromethylphenylcarbenes. Carbene-Carbene Interconversion on the Singlet Energy Surface and Rearrangement to Trifluorobenzocyclobutene, Trifluorostyrene, and Trifluoromethylfulvenallenes." Australian Journal of Chemistry 68, no. 1 (2015): 36. http://dx.doi.org/10.1071/ch14097.

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The four isomeric α-, ortho-, meta-, and para-trifluoromethylphenylcarbenes were generated by photolysis of the corresponding 3-phenyl-3-trifluoromethyldiazirene 1 or the four isomeric trifluoromethylphenyldiazomethanes 2 and 4–6. The four corresponding triplet trifluoromethylphenylcarbenes 3 and 7–9 were observed by electron spin resonance (ESR) spectroscopy in Ar matrices at 14 K. The α- and ortho-carbenes 3 and 7 and the ortho- and para-carbenes 7 and 9 interconvert partially when generated by short-wavelength photolysis (350 nm) before intersystem crossing to the triplet states. The triple

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9

Ibrahim, Yusria R. "Synthesis of imidazo- and pyrazolothiadiazoles from dithiobiureas and dimethyl ethynedicarboxylate." Journal of Chemical Research 2009, no. 10 (2009): 602–6. http://dx.doi.org/10.3184/030823409x12510192920270.

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Microwave irradiation of 1-substituted-2, 5-dithiobiureas and 1, 6-disubstituted-2, 5-dithiobiureas with dimethyl ethynedicarboxylate gave methyl 2-{6-oxo-2-(substituted amino)imidazo-[2, 1- b][1, 3, 5]thiadiazol-5(6 H)-ylidene} acetate and methyl 7-oxo-1, 3-bis(substituted imino)-3, 7-dihydro-1 H-pyrazolo[1, 2- c][1, 3, 4]thiadiazole-5-carboxylate. Rationales for these transformations are presented.

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10

Jin Liu, Jin Liu, Juan Zhao Juan Zhao, and Jiu fu Lu Jiu fu Lu. "Synthesis, Crystal Structure and Antitumor Activity of 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine." Journal of the chemical society of pakistan 42, no. 4 (2020): 591. http://dx.doi.org/10.52568/000663.

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The title compound, 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)- 7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidine (C26H16Cl2F3N3, Mr = 498.32) has been synthesized by condensation of 4,4,4-trifluoro-1-(p-tolyl)butane- 1,3-dione with 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine. The latter was prepared from 2,4-dichlorophenylaceton itrile and ethyl benzoate through Claisen condensation and then cyclization with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the title compound possesses marked inhibition against the proliferation of human lung aden

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11

Jin Liu, Jin Liu, Juan Zhao Juan Zhao, and Jiu fu Lu Jiu fu Lu. "Synthesis, Crystal Structure and Antitumor Activity of 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine." Journal of the chemical society of pakistan 42, no. 4 (2020): 591. http://dx.doi.org/10.52568/000663/jcsp/42.04.2020.

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The title compound, 3-(2,4-dichlorophenyl)-2-phenyl-5-(p-tolyl)- 7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidine (C26H16Cl2F3N3, Mr = 498.32) has been synthesized by condensation of 4,4,4-trifluoro-1-(p-tolyl)butane- 1,3-dione with 4-(2,4-dichlorophenyl)-3-phenyl-1H-pyrazol-5-amine. The latter was prepared from 2,4-dichlorophenylaceton itrile and ethyl benzoate through Claisen condensation and then cyclization with hydrazine hydrate. The crystal structure of the title compound was determined. In addition, the title compound possesses marked inhibition against the proliferation of human lung aden

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12

Farrán, M. Ángeles, M. Ángels Bonet, Rosa M. Claramunt, M. Carmen Torralba, Ibon Alkorta, and José Elguero. "The structures of 1,4-diaryl-5-trifluoromethyl-1H-1,2,3-triazoles related to J147, a drug for treating Alzheimer's disease." Acta Crystallographica Section C Structural Chemistry 74, no. 4 (2018): 513–22. http://dx.doi.org/10.1107/s2053229618004394.

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J147 [N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N′-(3-methoxybenzylidene)acetohydrazide] has recently been reported as a promising new drug for the treatment of Alzheimer's disease. The X-ray structures of seven new 1,4-diaryl-5-trifluoromethyl-1H-1,2,3-triazoles, namely 1-(3,4-dimethylphenyl)-4-phenyl-5-trifluoromethyl-1H-1,2,3-triazole (C17H14F3N3, 1), 1-(3,4-dimethylphenyl)-4-(3-methoxyphenyl)-5-trifluoromethyl-1H-1,2,3-triazole (C18H16F3N3O, 2), 1-(3,4-dimethylphenyl)-4-(4-methoxyphenyl)-5-trifluoromethyl-1H-1,2,3-triazole (C18H16F3N3O, 3), 1-(2,4-dimethylphenyl)-4-(4-methoxyphenyl)-5-trifluo

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13

Klein, Hans-Friedrich, Michael Helwig, Michael Karnop, et al. "Tris(trimethylphosphine)cobalt(0) Compounds Containing Azaolefinic Ligands — Syntheses and Structures of Benzo[c]cinnoline and Phenylisocyanate Complexes." Zeitschrift für Naturforschung B 48, no. 6 (1993): 785–93. http://dx.doi.org/10.1515/znb-1993-0613.

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Mononuclear cobalt(0) complexes Co(η2-azaolefin)(PMe3)3 (azaolefin = benzo[c]cinnoline (1), p-dimethylamino-phenyl(phenyl)diazene (2), 1/2 diazobenzene (3), bis(p-tolyl)diazene (4), bis(p-fluorphenyl)diazene (5), bis(p-trifluoromethyl-phenyl)diazene (6), phenylisocyanate (7)) are obtained from Co(cyclo-C5H8)(PMe3)3 by substitution of the olefin. X-ray crystal structure determinations of 1 and 7 show tetrahedral arrangements of ligands around the cobalt atom. By reaction with carbon monoxide carbonyl(phosphine)cobalt(0) complexes are formed. 7 catalyses the cyclotrimerization of phenylisocyanat

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14

Avasthi, Kamlakar, Lakshmi Shukla, Ruchir Kant, and Krishnan Ravikumar. "Folded conformations due to arene interactions in dissymmetric and symmetric butylidene-linker models based on pyrazolo[3,4-d]pyrimidine, purine and 7-deazapurine." Acta Crystallographica Section C Structural Chemistry 70, no. 6 (2014): 555–61. http://dx.doi.org/10.1107/s2053229614009449.

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The butylidene-linker models 1-[2-(2,6-dimethylsulfanyl-9H-purin-9-yl)-2-methylidenepropyl]-4,6-bis(methylsulfanyl)-1H-pyrazolo[3,4-d]pyrimidine, C18H20N8S4, (XI), 7,7′-(2-methylidenepropane-1,3-diyl)bis[3-methyl-2-methylsulfanyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one], C20H22N6O2S2, (XIV), and 7-[2-(4,6-dimethylsulfanyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-2-methylidenepropyl]-3-methyl-2-methylsulfanyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, C19H21N7OS3, (XV), show folded conformations in solution, as shown by1H NMR analysis. This folding carries over to the crystalline state. Intramolecular π–π int

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15

Horstmann, Jan, Stefanie Reger, Beate Neumann, Hans-Georg Stammler, and Norbert W. Mitzel. "One-pot desilylation-Sonogashira coupling." Zeitschrift für Naturforschung B 72, no. 7 (2017): 489–95. http://dx.doi.org/10.1515/znb-2017-0027.

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AbstractCoupling of diethynyldiphenylsilane (1) with aryl halides under Sonogashira conditions affords the symmetrical diarylacetylenes bis(2-methylpyridin-5-yl)acetylene (2), bis(4-fluorophenyl)acetylene (3) and bis(4-trifluoromethylphenyl)acetylene (4) in 60% to 82% yield. In the case of 2, the by-product bis(2-methylpyridin-5-yl)butadiyne (2a) was isolated in 12% yield. The occurring desilylation reaction was investigated by treating bis(phenylethynyl)diphenylsilane (5) under the same conditions. The formation of 1-fluoro-4-(phenylethynyl)benzene (6), 1-trifluoromethyl-4-(phenylethynyl)benz

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16

Bawrlin, GB, SJ Ireland, TMT Nguyen, B. Kotecka, and KH Rieckmann. "Potential Antimalarials. XX. Mannich Base Derivatives of 2-[7-Chloroquinolin-4-ylamino and 7-Bromo(and 7-trifluoromethyl)-1,5-naphthyridin-4-ylamino]-4-chloro(or 4- or 6-t-Butyl or 4- or 5-fluoro)phenols and 4(or 6)-t-Butyl-2-(7-trifluoromethylquinolin-4-ylamino)phenol." Australian Journal of Chemistry 47, no. 6 (1994): 1143. http://dx.doi.org/10.1071/ch9941143.

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Syntheses are reported for some mono- and di-Mannich base derivatives of 4-chloro-, 3- or 4-fluoro-, or 2- or 4-t-butyl-substituted 2-(7′-chloroquinolin-4′-ylamino)phenols and 2-[7′-bromo(and 7′-trifluoromethyl)-1′,5′-naphthyridin-4′-ylamino]phenols. In tests against the FC-27 isolate of Plasmodium falciparum, the most active compound was 2-(7′-chloroquinolin-4′-ylamino)-5-fluoro-4,6-bis(piperidin-1′-ylmethyl)phenol (16) with IC50 12.2 nM.

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17

Gupta, Ravindra Kumar, Ahamad Imran, and Aslam Khan. "Anionic Effect on Electrical Transport Properties of Solid Co2+/3+ Redox Mediators." Polymers 16, no. 10 (2024): 1436. http://dx.doi.org/10.3390/polym16101436.

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In a solid-state dye-sensitized solar cell, a fast-ion conducting (σ25°C > 10−4 S cm−1) solid redox mediator (SRM; electrolyte) helps in fast dye regeneration and back-electron transfer inhibition. In this work, we synthesized solid Co2+/3+ redox mediators using a [(1 − x)succinonitrile: x poly(ethylene oxide)] matrix, LiX, Co(tris-2,2′-bipyridine)3(bis(trifluoromethyl) sulfonylimide)2, and Co(tris-2,2′-bipyridine)3(bis(trifluoromethyl) sulfonylimide)3 via the solution-cast method, and the results were compared with those of their acetonitrile-based liquid counterparts. The notation x is a

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18

Barlin, GB, SJ Ireland, TMT Nguyen, B. Kotecka, and KH Rieckmann. "Potential Antimalarials. XXI. Mannich Base Derivatives of 4-[7-Chloro(and 7-trifluoromethyl)quinolin-4-ylamino]phenols." Australian Journal of Chemistry 47, no. 8 (1994): 1553. http://dx.doi.org/10.1071/ch9941553.

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Syntheses are reported for 4-(7-chloroquinolin-4-ylamino)-2,6-bis(piperidin-1-ylmethyl)phenol (2) and its 3-fluoro and 3-piperidinyl derivatives. Some mono-Mannich analogues with 2-fluoro, 2-t-butyl and 3-trifluoromethyl substituents have also been prepared. In tests for antimalarial activity against the FC-27 and K-1 isolates of Plasmodium falciparum in vitro, compound (2) proved to be the most active (IC50 6.3-12.5 nM).

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19

Break, Laila Mohammed, та Wafa Saad Al-harthi. "Synthesis New of Nucleoside of 1,3-bis-(2,3,5-tri-O-Benzoyl-β-D-Ribofuranosyl)-8-(Trifluoromethyl)-2-Methyl-4-Quinazolinone". Proceedings 9, № 1 (2018): 57. http://dx.doi.org/10.3390/ecsoc-22-05694.

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Fluorinated nucleosides are very important for increased biological and chemical stability of organ fluorine compounds. Synthesis of (1H)-8-trifluloromethyl-2-methyl-4-quinazolinone 3 from 2-amino-3-(trifluoromethyl) benzoic acid 1 was performed. Ribosylation of compound 4 with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-d-ribofuranose 5 using the silylation method created the benzoylated nucleoside derivative 6. Debenzoylation of the protected nucleoside 6 via reaction with sodium metal in dry methanol to create the corresponding free nucleoside 1,3-bis-(2,3,5-tri-O-benzoyl-β-d-ribofuranosyl)-8-(trifluo

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20

Roesky, Herbert W., Hartmut Hofmann, Mathias Noltemeyer, and George M. Sheldrick. "Synthese und Kristallstruktur von 1,1,1,3,3,3-Hexafluor-2-propylamino-1-thiooxamid / Synthesis and Crystal Structure of 1,1,1,3,3,3-Hexafluoro-2-propylamino-1-thiooxamide." Zeitschrift für Naturforschung B 40, no. 1 (1985): 124–26. http://dx.doi.org/10.1515/znb-1985-0124.

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Dithiooxamide 1 reacts with hexafluoroacetone 2 at room temperature to yield 1,1,1,3,3,3-hexafluoro-2-propylamino-1-thiooxamide 3 and sulfur. The modes of formation of the bis(trifluoromethyl)-methyl group from hexafluoroacetone, the migration of oxygen and the elimination of sulfur are not clear. Crystals of 3 are monoclinic, space group Cc, with a = 2865.3(13), b = 924.4(9), c = 702.9(6) pm, β = 93.3(7)°. The structure was refined to R = 0.067 from 614 reflections

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21

Gangadhar, S. Bhopalkar. "Synthesis and in-vitro Anticancer Activity of 3 -Cyano- 9, 12-Dimethyl -4, 14-Diimino- 2-Methylthio- Pyrimido[2,3-b] Pyrazolo[3,4-e] Pyrimido[2,3-b][1,3] Benzothiazole and its 2-Substituted Derivatives." Chemistry Research Journal 8, no. 4 (2023): 13–19. https://doi.org/10.5281/zenodo.11352251.

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<strong>Abstract </strong> A new heterocyclic compound 3 -Cyano- 9, 12-dimethyl -4, 14-diimino- 2-methylthio- pyrimido[2,3<em>-b</em>] pyrazolo[3,4<em>-e</em>] pyrimido[2,3<em>-b</em>][1,3] benzothiazole 3 has been synthesised by the reaction of 3-amino- 4-imino- 6, 9-dimethyl- pyrazolo-[3, 4<em>-e</em>] pyrimido [2, 3<em>-b</em>] [1, 3] benzothiazole 2  with bis - methylthio methylene malononitrile  in presence of anhydrous K<sub>2</sub>CO<sub>3</sub> in DMF. Compound 3 has thiomethyl functionality at 2- position which was substituted by using selected nucleophiles like substituted

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22

Barlin, GB, SJ Ireland, TMT Nguyen, B. Kotecka, and KH Rieckmann. "Potential Antimalarials. XVIII. Some Mono- and Di-Mannich Bases of 3-[7-Chloro(and trifluoromethyl)quinolin-4-ylamino]phenol." Australian Journal of Chemistry 46, no. 11 (1993): 1685. http://dx.doi.org/10.1071/ch9931685.

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Syntheses are reported for mono- and di-Mannich base derivatives of 3-[7-chloro(and trifluoro-methyl)quinolin-4-ylamino]phenols by Mannich reaction on 3-[7-chloro(and trifluoromethyl )-quinolin-4-ylamino]phenols or by condensation of Mannich base derivatives of 3-aminophenol, prepared from 3-nitrophenol, with the appropriate 4-chloroquinoline. The antimalarial activity of 3-(7′-chloroquinolin-4′-ylamino)-2,6-bis[ pyrrolidin-1″-ylmethyl -(or piperidin-1″-ylmethyl)]phenol against the FC-27 isolate of Plasmodium falciparum was comparable to that of chloroquine, and it was not significantly dimini

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23

Ghorab, Mostafa M., Mansour S. Al-Said, and Reem K. Arafa. "Design, Synthesis and Potential Anti-Proliferative Activity of Some Novel 4-Aminoquinoline Derivatives." Acta Pharmaceutica 64, no. 3 (2014): 285–97. http://dx.doi.org/10.2478/acph-2014-0030.

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Abstract Novel nineteen compounds based on a 4-aminoquinoline scaffold were designed and synthesized as potential antiproliferative agents. The new compounds were N-substituted at the 4-position by aryl or heteroaryl (1-9), quinolin- 3-yl (10), 2-methylquinolin-3-yl (11), thiazol-2-yl (12), and dapsone moieties (13, 14 and 18). Bis-compounds 15, 16 and 19 were also synthesized to assess their biological activity. All the newly synthesized comounds were tested for in vitro antiproliferative activity against the MCF-7 breast cancer cell line. Seventeen of the novel compounds showed higher activi

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Ben-Jonathan, Nira, Shenglin Chen, Joseph A. Dunckley, Christopher LaPensee та Sanjay Kansra. "Estrogen Receptor-α Mediates the Epidermal Growth Factor-Stimulated Prolactin Expression and Release in Lactotrophs". Endocrinology 150, № 2 (2009): 795–802. http://dx.doi.org/10.1210/en.2008-0756.

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Epidermal growth factor (EGF) is a potent regulator of cell function in many cell types. EGF-receptor (EGFR/ErbB1)-activated Erk1/2 has been reported to activate estrogen receptor (ER) in an estrogen (E2)-independent manner. In the pituitary lactotrophs, both EGF and E2 stimulate prolactin (PRL) release, but the nature of interactions between ErbB and ERα signaling is unknown. Our objectives were to 1) characterize EGF-induced PRL release, 2) determine whether this effect requires ERα, and 3) determine the molecular basis for cross talk between ErbB and ERα signaling pathways. Using GH3 cells,

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Chan, Karen Kar-Loen, Thomas Ho-Yin Leung, David Wai Chan та ін. "Targeting estrogen receptor subtypes (ERα and ERβ) with selective ER modulators in ovarian cancer". Journal of Endocrinology 221, № 2 (2014): 325–36. http://dx.doi.org/10.1530/joe-13-0500.

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Ovarian cancer cells express both estrogen receptor α (ERα) and ERβ, and hormonal therapy is an attractive treatment option because of its relatively few side effects. However, estrogen was previously shown to have opposite effects in tumors expressing ERα compared with ERβ, indicating that the two receptor subtypes may have opposing effects. This may explain the modest response to nonselective estrogen inhibition in clinical practice. In this study, we aimed to investigate the effect of selectively targeting each ER subtype on ovarian cancer growth. Ovarian cancer cell lines SKOV3 and OV2008,

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Barlin, GB, TMT Nguyen, B. Kotecka, and KH Rieckmann. "Potential Antimalarials. XV. Di-Mannich Bases of 2-(7'-Chloroquinolin-4'-ylamino)phenol and 2-[7'-Bromo( and trifluoromethyl)-1',5'-naphthyridin-4'-ylamino]phenol." Australian Journal of Chemistry 45, no. 10 (1992): 1651. http://dx.doi.org/10.1071/ch9921651.

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A total of 26 di-Mannich base derivatives of 2-(7'-chloroquinolin-4'-ylamino)phenol and 2-[7'- bromo (and trifluoromethyl )-1',5'-naphthyridin-4'-ylino]phenol, such as 2-(7'-chloroquinolin- 4'-ylamino)-4,6-bis( piperidin-1″-ylmethyl )phenol, together with some 3- and 5-methyl derivatives and mono-Mannich analogues, have been prepared by condensation of the 4-chloro heterocycle with the appropriate Mannich base derivatives of 2-aminophenols. In in vitro tests against Plasmodium falciparum, many of the di-Mannich base derivatives of 2-(7'-chloroquinolin-4'-ylarnino)phenol exhibited activity comp

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Nongrum, Stability, Susma Das, Shikpika Khanikar, and Jai Narain Vishwakarma. "Synthesis, structural elucidation and X-ray crystallographic studies of 1-(3,5-bis(trifluoromethyl)phenyl)-3-(dimethylamino)prop-2-en-1-one." European Journal of Chemistry 10, no. 4 (2019): 381–85. http://dx.doi.org/10.5155/eurjchem.10.4.381-385.1922.

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A new enaminone was synthesized by reacting 3,5-bis-(trifluoromethyl)acetophenones and N,N-dimethylformamide dimethyl acetal and its detailed structural and crystalline properties were studied. The crystal data were found to be as C13H11F6NO, monoclinic, space group P21/c (no. 14), a = 8.1556(8) Å, b = 24.877(3) Å, c = 7.6067(7) Å, β = 116.745(6)°, V = 1378.2(3) Å3, Z = 4, T = 293(2) K, μ(MoKα) = 0.150 mm-1, Dcalc = 1.500 g/cm3, 40777 reflections measured (5.594° ≤ 2Θ ≤ 56.786°), 3413 unique (Rint = 0.1040, Rsigma = 0.0584) which were used in all calculations. The final R1 was 0.0771 (I > 2

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Beus, Maja, Diana Fontinha, Jana Held, Zrinka Rajić, Miguel Prudêncio, and Branka Zorc. "Synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides." Acta Pharmaceutica 69, no. 2 (2019): 233–48. http://dx.doi.org/10.2478/acph-2019-0019.

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Abstract The paper is focused on the synthesis and screening of the antiplasmodial activity of novel fumardiamides 5–10 with the mefloquine pharmacophore and a Michael acceptor motif. Multi-step reactions leading to the title compounds included two amide bond formations. The first amide bond was achieved by the reaction of (E)-ethyl 4-chloro-4-oxobut-2-enoate (1) and N1-(2,8-bis(trifluoromethyl)quinolin-4-yl) butane-1,4-diamine (2). The obtained ester 3 was hydrolyzed and gave acid 4, which then reacted with the selected halogenanilines in the presence of HATU/DIEA and formed products 5–10. Ti

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Luan, Ming-Zhu, Hui-yun Wang, Mei Zhang, et al. "Crystal structure of (E)-2-(3,5-bis(trifluoromethyl)benzylidene)-7-methoxy-3,4-dihydronaphthalen- 1(2H)-one, C20H14F6O2." Zeitschrift für Kristallographie - New Crystal Structures 236, no. 1 (2021): 61–63. http://dx.doi.org/10.1515/ncrs-2020-0446.

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Abstract${\text{C}}_{20}{\text{H}}_{14}{\text{F}}_{6}{\text{O}}_{2}$, monoclinic, P21/c (no. 14), a = 14.791(2) Å, b = 8.5303(9) Å, c = 15.531(3) Å, β = 115.474(19)°, V = 1769.1(5) Å3, Z = 4, ${R}_{gt}$(F) = 0.0574, $w\,{R}_{\text{ref}}$(F2) = 0.1451, T = 100 K.CCDC no.: 2016723

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Jones, P. G., A. J. Kirby, and J. K. Parker. "Bond length and reactivity: 1-arylethyl ethers and esters. 7. Structure of 1-[3,5-bis(trifluoromethyl)phenyl]ethyl 4-nitrobenzoate." Acta Crystallographica Section C Crystal Structure Communications 45, no. 2 (1989): 218–21. http://dx.doi.org/10.1107/s0108270188010200.

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Yi-Lin Gong, Peng Dai, Ye Chen, Shi Ding, and Ju Liu. "Synthesis, Crystal Structure and Biological Activity of 7-(4-Methylpiperazin-1-Yl)-5-[4-(Trifluoromethyl)Phenyl]pyrazolo[1,5-a]Pyrimidine-3-Carbonitrile." Crystallography Reports 65, no. 7 (2020): 1111–16. http://dx.doi.org/10.1134/s1063774520070068.

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Aigeldinger, Elisabeth, Lilliana Brandao, Troy Powell, et al. "Crystal structure of a trifluoromethyl benzoato quadruple-bonded dimolybdenum complex." Acta Crystallographica Section E Crystallographic Communications 78, no. 2 (2022): 154–58. http://dx.doi.org/10.1107/s205698902200010x.

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The study of quadruple bonds between transition metals, in particular those of dimolybdenum, has revealed much about the two-electron bond. The solid-state structure of the quadruple-bonded dimolybdenum(II) complex tetrakis[μ-4-(trifluoromethyl)benzoato-κ2 O:O′]bis[(tetrahydrofuran-κO)molybdenum(II)] 0.762-pentane 0.238-tetrahydrofuran solvate, [Mo2(p-O2CC6H4CF3)4·2THF]·0.762C5H12·0.238C4H8O or [Mo2(C8H4F3O2)4(C4H8O)2]·0.762C5H12·0.238C4H8O is reported. The complex crystallizes within a triclinic cell and low symmetry (P\overline{1}) results from the intercalated pentane/THF solvent molecules.

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BAKER, GARY A., FRANK V. BRIGHT, MICHAEL R. DETTY, SIDDHARTH PANDEY, COREY E. STILTS, and HUIRONG YAO. "The influence of phenylethynyl linkers on the photo-physical properties of metal-free porphyrins." Journal of Porphyrins and Phthalocyanines 04, no. 07 (2000): 669–83. http://dx.doi.org/10.1002/1099-1409(200011)4:7<669::aid-jpp287>3.0.co;2-m.

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Series of 5,10,15,20-tetraarylporphyrins 1 and 5,10,15,20-tetrakis[4-(arylethynyl)phenyl]porphyrins 2 were prepared via condensation of pyrrole with the appropriate benzaldehyde or 4-(arylethynyl)benzaldehyde derivative (3). Condensation of meso-phenyldipyrromethane with mixtures of benzaldehyde and 4-(trimethylsilyl-ethynyl)benzaldehyde gave a separable mixture of mono- (6), bis- (both cis-7 and trans-8) and tris[4-(trimethylsilylethynyl)phenyl]porphyrin (9). Following removal of the trimethylsilyl groups of 6–9, the 4-ethynylphenyl groups of 11–14 were coupled to 1-iodo-3,5-di(trifluoromethy

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Gao, Yanshuang, Huasen Wang, Jie Jia, et al. "Intrinsically Negative Photosensitive Polyimides with Enhanced High-Temperature Dimensional Stability and Optical Transparency for Advanced Optical Applications via Simultaneous Incorporation of Trifluoromethyl and Benzanilide Units: Preparation and Properties." Polymers 14, no. 18 (2022): 3733. http://dx.doi.org/10.3390/polym14183733.

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Negative photosensitive polyimides (PSPIs) with the photo-patterned ability via the photocrosslinking reactions induced by the i-line (365 nm) and h-line (426 nm) emitting wavelengths in high-pressure mercury lamps have been paid increasing attention in semiconductor fabrication, optical fiber communications, and other advanced optoelectronic areas. In the current work, in view of the optical and thermo-mechanical disadvantages of the currently used negative PSPIs, such as the intrinsically photosensitive or auto-photosensitive systems derived from 3,3’,4,4’-benzophenonetetracarboxylic dianhyd

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35

Galajdová, Barbora, Jan Žitka, Lukáš Pavlovec, Olga Trhlíková, Jana Kredatusová, and Rafal Konefal. "Synthesis and Electrochemical Properties of Electrolytes Based on Phosphonium, Sulfonium and Imidazolium Ionic Liquids for Li-Ion Batteries." Chemické listy 117, no. 6 (2023): 373–83. http://dx.doi.org/10.54779/chl20230373.

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This work describes synthesis and characterization of three ionic liquids (IL) with imidazolium, phosphonium or sulfonium cations. These ILs were used as precursors for the preparation of electrolytes by adding various types of lithium salts. Thermal and electrochemical properties of the electrolytes were studied to assess their feasibility for usage in lithium-ion batteries (LIB). Ethylmethylimidazolium phosphonic acid ethyl ester [EtMeIm]+[EtPITE]– with added Li salts showed very low conductivities of about 0.02 mS cm–1 and a rather narrow electrochemical stability window of 4.3 V. Of all th

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36

Chen, Yun-Ju, Ming-Ting Lee, Hsiao-Chun Yao, Pei-Wen Hsiao, Ferng-Chun Ke та Jiuan-Jiuan Hwang. "Crucial Role of Estrogen Receptor-α Interaction with Transcription Coregulators in Follicle-Stimulating Hormone and Transforming Growth Factor β1 Up-Regulation of Steroidogenesis in Rat Ovarian Granulosa Cells". Endocrinology 149, № 9 (2008): 4658–68. http://dx.doi.org/10.1210/en.2008-0063.

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This study was to explore estrogen receptor (ER) involvement in FSH and TGFβ1-stimulated steroidogenesis in rat ovarian granulosa cells. We first determined the specific involvement of ERα and ERβ in the process, and then investigated the molecular interaction of ERα and transcription coregulators in FSH and TGFβ1 up-regulation of steroidogenic gene expression. Primary culture of ovarian granulosa cells from antral follicles of gonadotropin-primed immature rats was used. Interestingly, a selective ERα antagonist methyl-piperidino-pyrazole (MPP) [like ER antagonist ICI-182,780 (ICI)] decreased

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37

Delamere, C., C. Jakins, and E. Lewars. "On the generation of oxirene and dimethyloxirene by retro-DielsAlder reactions, and reactions of dimethyloxirene: a computational study." Canadian Journal of Chemistry 80, no. 1 (2002): 94–105. http://dx.doi.org/10.1139/v01-194.

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The isomerization of oxirene (oxacyclopropene) (1) to ketene, dimethyloxirene (7) to dimethylketene via the oxo carbene ("ketocarbene"), and the retro-DielsAlder extrusion of oxirene and dimethyloxirene from their formal adducts (9 and 24, respectively) with benzene were studied computationally. All species were optimized at the MP2(fc)/631G(df,p) level; the species involving 1 were also subjected to MP2(fc)/631G(df,p) frequency and single-point CCSD(T)/631G(df,p) calculations. At the CCSD(T)/631G(df,p)//MP2(fc)/631G(df,p) level 1 isomerized to ketene in one step with a barrier of 2.8 kJ

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38

Qin, Chunhua, Derek Morrow, Jessica Stewart та ін. "A new class of peroxisome proliferator-activated receptor γ (PPARγ) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3′-indolyl)-1-(p-substituted phenyl)methanes". Molecular Cancer Therapeutics 3, № 3 (2004): 247–60. http://dx.doi.org/10.1158/1535-7163.247.3.3.

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Abstract 1,1-Bis(3′-indolyl)-1-(p-trifluoromethylphenyl)methane (DIM-C-pPhCF3) and several p-substituted phenyl analogues have been investigated as a new class of peroxisome proliferator-activated receptor γ (PPARγ) agonists. Structure-activity studies in PPARγ-dependent transactivation assays in MCF-7 breast cancer cells show that 5–20 μm concentrations of compounds containing p-trifluoromethyl, t-butyl, cyano, dimethylamino, and phenyl groups were active, whereas p-methyl, hydrogen, methoxy, hydroxyl, or halogen groups were inactive as PPARγ agonists. Induction of PPARγ-dependent transactiva

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39

Chang, Wei-Ting, and Sheng-Nan Wu. "Effective Activation of BKCa Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4H)-one), Known to Be an Opener of KCNQ2/Q3 Channels." Pharmaceuticals 14, no. 5 (2021): 388. http://dx.doi.org/10.3390/ph14050388.

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QO-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-7(4H)-one) is a novel and selective activator of KCNQ2/KCNQ3 K+ channels. However, it remains largely unknown whether this compound can modify any other type of plasmalemmal ionic channel. The effects of QO-40 on ion channels in pituitary GH3 lactotrophs were investigated in this study. QO-40 stimulated Ca2+-activated K+ current (IK(Ca)) with an EC50 value of 2.3 μM in these cells. QO-40-stimulated IK(Ca) was attenuated by the further addition of GAL-021 or paxilline but not by linopirdine or TRAM-34. In

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40

Neda, Ion, Hans-Jürgen Plinta, and Reinhard Schmutzler. "Umsetzungen von 0,3-Dialkyl-1,3-diaza-2-chloro-5,6-benzo-1,3,2-phosphorinan-4-onen; Darstellung von P(III)-Derivaten / Reactions of 1,3-Dialkyl-1,3-diaza-2-chloro-5,6-benzo-1,3,2-phosphorinan-4-ones; Preparation of P(III) Derivatives." Zeitschrift für Naturforschung B 48, no. 3 (1993): 333–40. http://dx.doi.org/10.1515/znb-1993-0312.

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The reaction of 1,3-dimethyl-1,3-diaza-2-chloro-5,6-benzo-1,3,2-phosphorinan-4-one 1 with N-trimethylsilylacetamide 2 and 2-methylpiperidine hydrochloride furnished the P-substituted derivatives 3 and 4. The reaction of 1 with trimethylbromo- and trimethyliodosilane yielded the 2-bromo- and 2-iodo- substituted compounds 5 and 6. 1-Methyl-3-(2-chloroethyl)-1,3-diaza-2-chloro-5,6-benzo-1,3,2-phosphorinan-4-one 8 was prepared in the reaction of N-methyl-N'-(2-chloroethyl)-anthranilamide 7 with phosphorus trichloride. The reaction of 8 with N-trifluoromethyl-3-nitrophenylamine 9 or with sodium flu

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41

Vendilo, A. G., V. I. Chistov, and V. I. Privalov. "Thermodynamics of complexation of cesium with dibenzo-21-crown-7 and dibenzo-24-crown-8 in 1-butyl-3-methylimidazolium bis((trifluoromethyl)sulfonyl)imide." Russian Journal of Inorganic Chemistry 57, no. 4 (2012): 629–33. http://dx.doi.org/10.1134/s0036023612040262.

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42

Bouihi, Fatiha, Bruno Schmaltz, Fabrice Mathevet та ін. "D-π-A-Type Pyrazolo[1,5-a]pyrimidine-Based Hole-Transporting Materials for Perovskite Solar Cells: Effect of the Functionalization Position". Materials 15, № 22 (2022): 7992. http://dx.doi.org/10.3390/ma15227992.

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Donor–acceptor (D–A) small molecules are regarded as promising hole-transporting materials for perovskite solar cells (PSCs) due to their tunable optoelectronic properties. This paper reports the design, synthesis and characterization of three novel isomeric D-π-A small molecules PY1, PY2 and PY3. The chemical structures of the molecules consist of a pyrazolo[1,5-a]pyrimidine acceptor core functionalized with one 3,6-bis(4,4′-dimethoxydiphenylamino)carbazole (3,6-CzDMPA) donor moiety via a phenyl π-spacer at the 3, 5 and 7 positions, respectively. The isolated compounds possess suitable energy

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43

Dutta, Milan Ch, Kaushik Chanda, Jai N. Vishwakarma, and Philippe Helissey. "A facile one-pot synthesis of novel substituted 1,2,3,4-tetrahydropyrimidines Part 5 : Synthesis of bis[(l-alkyl/aralkyl)-5-benzoyl-6-methylthio-1,2,3,4-tetrahydropyrimidinyl]alkane and benzene, bis[3-phenyl-7-methyl-4,5,6,7-tetrahydropyrazolo[3,4-d]-pyrimidinyl]alkane and bis[1-benzyl-7-phenyl-1,2,3,4-tetrahydro-pyrazolo[1,5-a]triazinyl]alkane and benzene." Journal of Heterocyclic Chemistry 42, no. 5 (2005): 975–78. http://dx.doi.org/10.1002/jhet.5570420535.

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44

Tomorowicz, Łukasz, Beata Żołnowska, Krzysztof Szafrański, et al. "New 2-[(4-Amino-6-N-substituted-1,3,5-triazin-2-yl)methylthio]-N-(imidazolidin-2-ylidene)-4-chloro-5-methylbenzenesulfonamide Derivatives, Design, Synthesis and Anticancer Evaluation." International Journal of Molecular Sciences 23, no. 13 (2022): 7178. http://dx.doi.org/10.3390/ijms23137178.

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In the search for new compounds with antitumor activity, new potential anticancer agents were designed as molecular hybrids containing the structures of a triazine ring and a sulfonamide fragment. Applying the synthesis in solution, a base of new sulfonamide derivatives 20–162 was obtained by the reaction of the corresponding esters 11–19 with appropriate biguanide hydrochlorides. The structures of the compounds were confirmed by spectroscopy (IR, NMR), mass spectrometry (HRMS or MALDI-TOF/TOF), elemental analysis (C,H,N) and X-ray crystallography. The cytotoxic activity of the obtained compou

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Fisher, Kimberly D., Juan Codina, Snezana Petrovic, and Thomas D. DuBose. "Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway." American Journal of Physiology-Renal Physiology 303, no. 9 (2012): F1353—F1362. http://dx.doi.org/10.1152/ajprenal.00008.2012.

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Acid-secreting intercalated cells respond to changes in systemic pH through regulation of apical H+ transporters. Little is known about the mechanism by which these cells sense changes in extracellular pH (pHo). Pyk2 is a nonreceptor tyrosine kinase activated by autophosphorylation at Tyr402 by cell-specific stimuli, including decreased pH, and is involved in the regulation of MAPK signaling pathways and transporter activity. We examined whether the Pyk2 and MAPK signaling pathway mediates the response of transport proteins to decreased pH in outer medullary collecting duct cells. Immunoblot a

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46

Popovych, M. V., Ya R. Shalai, V. P. Hreniukh, et al. "Effect of thiazole derivative complexed with nanoscale polymeric carriers on cellular ultrastructure of murine lymphoma cells in vivo." Studia Biologica 15, no. 2 (2021): 15–24. http://dx.doi.org/10.30970/sbi.1502.653.

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Background. A pronounced cytotoxic action of the thiazole derivatives complexed with polymeric carriers on tumor cells in vitro was reported earlier, while no cytotoxicity of these compounds was detected toward noncancerous cells. It was found that thiazole derivatives at concentrations of 10 and 50 µM affected lymphoma cell ultrastructure in vitro. The purpose of this work was to investigate the effect of thiazole derivative 8-methyl-2-Me-7-[trifluoromethyl-phenylmethyl]-pyrazolo-[4,3-e]-[1,3]- thiazolo-[3,2-a]-pyrimidin-4(2H)-one (PP2) and its complexes with polymeric carriers poly(VEP-co-GM

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47

Pokladko-Kowar, Monika, Ewa Gondek, Andrzej Danel, et al. "Trifluoromethyl Substituted Derivatives of Pyrazoles as Materials for Photovoltaic and Electroluminescent Applications." Crystals 12, no. 3 (2022): 434. http://dx.doi.org/10.3390/cryst12030434.

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New 6-CF3-1H-pyrazolo[3,4-b]quinolines with a methyl and/or phenyl group attached to the pyrazole core (Molx (x = 1, 2, 3, 4)) were synthesized and characterized in terms of their optoelectronic applications: photovoltaic and electroluminescence. The fluorescence emissions of the investigated phenyl-decorated pyrazoloquinolines is caused by the photoinduced charge transfer p process occurring between the phenyl substituent and the pyrazoloquinoline core, while 1,3-dimethyl-6-CF3-1H-pyrazolo[3,4-b]quinoline exhibits an π,π*-type emission. The number of phenyls and their substitution positions m

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48

da Silva Araújo, Adriele, Adriana M. Moraes, Maria C. S. Lourenço, Cláudia O. Pessoa, Emerson T. da Silva, and Marcus V. N. de Souza. "Synthesis and Antibacterial Activity of Mefloquine-Based Analogs Against Sensitive and Resistant Mycobacterium tuberculosis Strains." Current Topics in Medicinal Chemistry 19, no. 9 (2019): 683–89. http://dx.doi.org/10.2174/1568026619666190304124952.

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Background and Introduction:Mefloquine, a drug used to prevent and treat malaria is described possessing activity against the Mycobacterium tuberculosis (Mtb) as well as against multidrugresistant tuberculosis (MDR) and other types of bacteria. Despite their importance, few compounds based on the Mefloquine nucleus have been synthesized and evaluated against TB.Materials and Methods:For the synthesis of all the compounds based on the Mefloquine nucleus we used a synthetic route which utilized the key derivative 4-methoxy-2,8-bis(trifluoromethyl)quinoline 2 as starting material. The compounds 3

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Nance, Kellie D., Emily L. Days, C. David Weaver, et al. "Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core." Journal of Medicinal Chemistry 60, no. 4 (2017): 1611–16. http://dx.doi.org/10.1021/acs.jmedchem.6b01706.

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Grubbs, Laura M., Shulin Ye, Mariam Saifullah, et al. "Correlation of the Solubilizing Abilities of Hexyl(trimethyl)ammonium bis((Trifluoromethyl)sulfonyl)imide, 1-Propyl-1-methylpiperidinium bis((Trifluoromethyl)sulfonyl)imide, and 1-Butyl-1-methyl-pyrrolidinium Thiocyanate." Journal of Solution Chemistry 40, no. 12 (2011): 2000–2022. http://dx.doi.org/10.1007/s10953-011-9770-7.

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