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Journal articles on the topic '709/.51'

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Published: 26 July 2024

Last updated: 31 July 2025

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1

El Editor. "Derechos humanos ; La situación del país." ECA: Estudios Centroamericanos 51, no. 573-574 (1996): 709–21. http://dx.doi.org/10.51378/eca.v51i573-574.6693.

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ТРЕТЬЯКОВА, А. С. "РАСПРЕДЕЛЕНИЕ ВИДОВОГО СОСТАВА РАСТЕНИЙ В ЕСТЕСТВЕННЫХ И АНТРОПОГЕННЫХ МЕСТООБИТАНИЯХ Г. ЕКАТЕРИНБУРГА, "БОТАНИЧЕСКИЙ ЖУРНАЛ"". Ботанический журнал, № 11 (2014): 1277–82. http://dx.doi.org/10.1134/s1234567814110081.

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Показано, что общий вектор преобразования флоры на урбанизированных территориях выражается в сокращении индигенных видов, увеличении доли апофитных и адвентивных. В растительных сообществах естественных местообитаний встречается более 75 % видов урбанофлоры Екатеринбурга - 709 видов. Среди них преобладают аборигенные виды (87 %), а адвентивные виды играют второстепенную роль. В составе растительных группировок антропогенных местообитаний насчитывается 613 видов, среди них заметно сокращается число аборигенных видов (49 %) и соответственно увеличивается число адвентивных: 51 против 13 % в естес

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Drenowatz, Clemens, Olivia Wartha, Jochen Klenk, Susanne Brandstetter, Martin Wabitsch, and Jürgen Steinacker. "Differences in Health Behavior, Physical Fitness, and Cardiovascular Risk in Early, Average, and Late Mature Children." Pediatric Exercise Science 25, no. 1 (2013): 69–83. http://dx.doi.org/10.1123/pes.25.1.69.

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This study examined the association between biological maturity, CVD risk, fitness and health behavior in 709 (359 male, 350 female) 8-year-old children (range: 6.3–8.9 years). Sports participation and sedentary behavior was assessed via parent questionnaire. Height and weight was measured and maturity status was predicted based on % of adult-height reached. Fitness was assessed via a test battery and CVD risk was determined using mean arterial pressure, cholesterol and intra-abdominal fat. BMIpercentiles (BMIPCT) differed significantly among early, average and late maturing children. Early ma

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Caylan, Refik, Ali Titiz, Maurizio Falcioni, et al. "Myringoplasty in Children: Factors Influencing Surgical Outcome." Otolaryngology–Head and Neck Surgery 118, no. 5 (1998): 709–13. http://dx.doi.org/10.1177/019459989811800529.

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Age, size, and site of perforation, condition of the ear, status of the contralateral ear, grafting materials, and more are considered factors influencing the success rates in myringoplasties in children. The ambivalence in results is mainly due to nonhomogeneous patient groups. In an effort to compose groups as homogeneous as possible for analysis of influencing factors, a retrospective study of 51 pediatric myringoplasty cases (51 ears) was undertaken. All patients had perforations caused by simple chronic otitis media. The overall surgical success rate was 82.3% at 18 months, and for young

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Tian, Erming, Joshua Epstein, Pingping Qu, et al. "Deletion of TP53 (17p13) Is Associated with Poor Outcome for Newly Diagnosed High-Risk Multiple Myeloma." Blood 126, no. 23 (2015): 2982. http://dx.doi.org/10.1182/blood.v126.23.2982.2982.

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Abstract Introduction In multiple myeloma (MM), deletion of chromosome 17 p13 (del17p) is a poor prognostic feature. The percentage of cells carrying an abnormality has been reported to be important with thresholds of 20% being taken generally but thresholds as high as 60% being suggested more recently. We have reported previously in the Total Therapy (TT)-2 trial (NCT00083551) for newly diagnosed (ND) MM that del17p is an adverse prognostic factor (Blood 112: 4235). The TT3 trial (NCT00081939) incorporated Brtezomib into tandem Melphalan-based autotransplants with DT-PACE for induction/consol

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Tiến Kiên, Nguyễn. "Nghiên cứu ứng dụng số liệu mưa vệ tinh mô phỏng lũ khu vực trung lưu sông Mã". Vietnam Journal of Hydrometeorology 709, № 1 (2020): 51–62. http://dx.doi.org/10.36335/vnjhm.2020(709).51-62.

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Ellis, Frank. "Growing points in radiotherapy since 1930. The 65th Mackenzie Davidson Memorial Lecture 1984." British Journal of Radiology 60, no. 709 (1987): 51–68. http://dx.doi.org/10.1259/0007-1285-60-709-51.

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Mastboim, Niv Samuel, Tanya Gottlieb, Isaac Srugo, et al. "2624. Viral Pneumonia in Children: Facing the Challenge Using the Host Response." Open Forum Infectious Diseases 6, Supplement_2 (2019): S914. http://dx.doi.org/10.1093/ofid/ofz360.2302.

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Abstract Background Diagnosing viral pneumonia in children is challenging. Chest radiographic imaging and clinical findings cannot reliably distinguish viral from bacterial pneumonia. Furthermore, pathogen-based diagnosis is limited by inaccessible site of infection and high asymptomatic detection rates. The objectives of this analysis were twofold: first, to establish pneumonia etiology by applying a rigorous expert panel process, and second, to evaluate whether a novel host-immune signature that integrates viral induced proteins TRAIL and IP-10 together with bacterial CRP, can accurately dif

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Flores, Claudio J., and Luis Augusto Casanova. "Prognostic factors for overall survival in non-Hodgkin lymphomas: Nonlinear effect of continuous covariates." Journal of Clinical Oncology 31, no. 15_suppl (2013): e19538-e19538. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e19538.

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e19538 Background: To evaluate prognostic factors in patients with primary non-Hodgkin lymphomas (NHL). Methods: We retrospectively analyzed prognostic factors (PFs) for overall survival (OS) in 2160 patients (pts) with NHL treated at INEN between 1990-2002. PFs were determinate according to Cox model with P-splines. Results: The median age was 54 years (range 14 - 96) and 51% were male. The majority of the pts had good performance status (73%, WHO 0-1). The Ann Arbor stage was I-II in 51%, III-IV in 49% and B symptoms were present in 38% of the pts. The hemoglobin (Hb) was low in 48%. Leukocy

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Hamako, Jiharu, Sachiyo Nishida, Shosaku Nomura, et al. "Purification and Characterization of Kaouthiagin, a von Willebrand Factor-Binding and -Cleaving Metalloproteinase from Naja kaouthia Cobra Venom." Thrombosis and Haemostasis 80, no. 09 (1998): 499–505. http://dx.doi.org/10.1055/s-0037-1615236.

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SummaryA von Willebrand factor (vWF)-binding and -cleaving metalloproteinase, termed “kaouthiagin”, was purified from the venom of cobra snake Naja kaouthia. Kaouthiagin is a monomer with a molecular mass of about 46 kDa and 51 kDa under non-reducing and reducing conditions, respectively, and the N-terminal amino acid sequence is homologous to high molecular mass snake venom metalloproteinases. Kaouthiagin bound to vWF in a divalent ion-independent manner, but the reduced kaouthiagin failed to interact with vWF, suggesting that the protein conformation maintained by intrachaindisulfide linkage

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Cope, RL. "Rich but varied?: Lynch, Mary Jo, ed ‘Research questions for the twenty-first century’,Library trendsvol 51 n°4 (2003): pp499–709 [entire issue]. US$28.00 soft ISSN 00242594." Australian Library Journal 53, no. 3 (2004): 308–9. http://dx.doi.org/10.1080/00049670.2004.10721659.

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Оболенский, Денис Михайлович, та Виктория Игоревна Шевченко. "Использование метода RAG и больших языковых моделей в интеллектуальных образовательных экосистемах". Экономика. Информатика 51, № 3 (2024): 699–709. http://dx.doi.org/10.52575/2687-0932-2024-51-3-699-709.

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В статье рассматривается использование метода Retrieval-Augmented Generation (RAG) и больших языковых моделей в интеллектуальных образовательных экосистемах. Предложено использование больших языковых моделей для улучшения представления образовательных ресурсов, вакансий и предпочтений пользователей в рекомендательных системах. Рассмотрено применение метода RAB для дополнения знаний больших языковых моделей новыми данными без дополнительного обучения. В примере реализации в интеллектуальной образовательной экосистеме показано применение библиотеки langchain, языковой модели GigaChat и векторной

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Kleiv, Ø., A. Folkestad, J. Høkedal, K. Sørensen, and E. Aas. "Estimation of upward radiances and reflectances at the surface of the sea from above-surface measurements." Ocean Science 11, no. 5 (2015): 779–88. http://dx.doi.org/10.5194/os-11-779-2015.

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Abstract. During 4 field days in the years 2009–2011, 22 data sets of measurements were collected in the inner Oslofjord, Norway. The data consist of recordings of spectral nadir radiances in air and water as well as spectral downward irradiance in air. The studied wavelengths are 351, 400, 413, 443, 490, 510, 560, 620, 665, 681, 709 and 754 nm. The water-leaving radiance and the reflected radiance at the sea surface have been obtained from the measured nadir radiances in air and water, where the latter radiance has been extrapolated upwards to the surface. For comparison we present a simpler

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Love, R. R., N. V. Dinh, T. T. Quy, et al. "Survival with adjuvant surgical oophorectomy and tamoxifen in premenopausal women with operable breast cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 552. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.552.

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552 Background: Reports of randomized trials evaluating adjuvant ovarian suppression or ablation with and without tamoxifen are limited in number, useful comparative data and long-term follow-up. Methods: From 1993–99 we recruited 709 Vietnamese and Chinese premenopausal women with clinical stage II-III operable breast cancer to a multi-site randomized prospective clinical trial of immediate pre-mastectomy adjuvant surgical oophorectomy followed by tamoxifen for 5 years (n=356) or mastectomy alone with the same combined hormonal therapy on recurrence of disease (n=353).The primary study endpoi

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Love, Richard R., Nguyen Van Dinh, Tran Tu Quy, et al. "Survival After Adjuvant Oophorectomy and Tamoxifen in Operable Breast Cancer in Premenopausal Women." Journal of Clinical Oncology 26, no. 2 (2008): 253–57. http://dx.doi.org/10.1200/jco.2007.11.6061.

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PurposeWorldwide, approximately 750,000 new cases of breast cancer are diagnosed annually in premenopausal women with limited economic resources. Longer-term survival benefits from adjuvant therapies in such women with operable breast cancer are unknown.Patients and MethodsFrom 1993 to 1999, we recruited 709 premenopausal women with operable breast cancer to a multisite randomized clinical trial of adjuvant oophorectomy and tamoxifen for 5 years or observation and this combined hormonal therapy on recurrence.ResultsWith a median follow-up of 7.0 years, disease-free and overall survival were si

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Jensen, Kasper Yde, Kathrine Lederballe Grøn, Bente Glintborg, and Merete Lund Hetland. "Effectiveness of ixekizumab in 709 real-world patients with axial spondyloarthritis and psoriatic arthritis: a nationwide cohort study." RMD Open 11, no. 3 (2025): e005806. https://doi.org/10.1136/rmdopen-2025-005806.

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Objectives To explore real-world effectiveness of ixekizumab in Danish patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). Methods Observational cohort study based on data from the Danish nationwide quality registry, DANBIO. Patients with axSpA and PsA initiating ixekizumab (an interleukin 17 inhibitor (IL-17i)) between 2017 and 2024 were included. Outcomes were 6-, 12- and 24-month retention rates and low disease activity (LDA)/remission after 6 months (axSpA: Axial Spondyloarthritis Disease Activity Score (ASDAS) <2.1/<1.3, PsA: Disease Activity index for Psori

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Kindler, Christoph H., Spencer C. Yost, and Andrew T. Gray. "Local Anesthetic Inhibition of Baseline Potassium Channels with Two Pore Domains in Tandem." Anesthesiology 90, no. 4 (1999): 1092–102. http://dx.doi.org/10.1097/00000542-199904000-00024.

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Background Recently, a new structural family of potassium channels characterized by two pore domains in tandem within their primary amino acid sequence was identified. These tandem pore domain potassium channels are not gated by voltage and appear to be involved in the control of baseline membrane conductances. The goal of this study was to identify mechanisms of local anesthetic action on these channels. Methods Oocytes of Xenopus laevis were injected with cRNA from five cloned tandem pore domain baseline potassium channels (TASK, TREK-1, TOK1, ORK1, and TWIK-1), and the effects of several lo

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Maclean, W., R. Singh, P. Mackenzie, et al. "The two-week rule colorectal cancer pathway: an update on recent practice, the unsustainable burden on diagnostics and the role of faecal immunochemical testing." Annals of The Royal College of Surgeons of England 102, no. 4 (2020): 308–11. http://dx.doi.org/10.1308/rcsann.2020.0019.

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Introduction Survival for colorectal cancer is improved by earlier detection. Rapid assessment and diagnostic demand have created a surge in two-week rule referrals and have subsequently placed a greater burden on endoscopy services. Between 2009 and 2014, a mean of 709 patients annually were referred to Royal Surrey County Hospital with a detection rate of 53 cancers per year giving a positive predictive value for these patients of 7.5%. We aimed to assess what impact the 2015 changes in National Institute for Health and Care Excellence referral criteria had on local cancer detection rate and

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Reman, Oumedaly, Arnaud Pigneux, Francoise Huguet, et al. "Central Nervous System Involvement in Adult Acute Lymphoblastic Leukemia (ALL) at Diagnosis and/or at First Relapse: Results from the GET-LALA Group." Blood 110, no. 11 (2007): 4326. http://dx.doi.org/10.1182/blood.v110.11.4326.4326.

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Abstract Outcome of adult ALL with central nervous system (CNS) involvement is not clearly defined. We studied 104 patients presenting with CNS involvement at diagnosis among 1493 patients (7%) included into the LALA-87 or LALA-94 trials, and 109 patients (9% of first remitters) presenting CNS disease at the time of first relapse among the 709 relapsing patients (15%) included initially in these trials. Treatment of patients presenting CNS involvement at diagnosis consisted in initial chemotherapy completed by 18 double or triple intrathecal injections associated with 15 to 20 Gy cranial irrad

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Hognert, Helena, Finn Egil Skjeldestad, Kristina Gemzell-Danielsson, et al. "Ecological study on the use of hormonal contraception, abortions and births among teenagers in the Nordic countries." BMJ Open 8, no. 10 (2018): e022473. http://dx.doi.org/10.1136/bmjopen-2018-022473.

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ObjectivesCompare hormonal contraceptive use, birth and abortion rates among teenagers in the Nordic countries. A secondary aim was to explore plausible explanations for possible differences between countries.DesignEcological study using national registry data concerning births and abortions among all women aged 15–19 years residing in Denmark, Finland, Iceland, Norway and Sweden 2008–2015. Age-specific data on prescriptions for hormonal contraceptives for the period 2008–2015 were obtained from national databases in Denmark, Norway and Sweden.SettingDenmark, Finland, Iceland, Norway and Swede

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Bashar, Mohammad Abul, Md Emdadul Haque, and Md Ziaul Islam. "Nutritional Status and Health Related Quality of Life Of Chronic Kidney Disease Patients." Journal of Preventive and Social Medicine 40, no. 2 (2022): 44–51. http://dx.doi.org/10.3329/jopsom.v40i2.61796.

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Background: Chronic kidney disease is a steadily growing health problem. Malnutrition is common in this irreversible state of kidney failure. The CKD along with malnutrition adversely affect the HRQOL of the patients. This study was conducted to assess the association between nutritional status and HRQOL of CKD patients. Methods: This cross-sectional study was conducted among 220 CKD patients at Gonoshasthaya Dialysis Centre in Dhaka of Bangladesh during the period from July 2019 to June 2020. Data were collected purposively by using a semi-structured questionnaire with face to face interview,

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Kontopantelis, Evangelos, Maria Panagioti, Tracey Farragher, et al. "Consultation patterns and frequent attenders in UK primary care from 2000 to 2019: a retrospective cohort analysis of consultation events across 845 general practices." BMJ Open 11, no. 12 (2021): e054666. http://dx.doi.org/10.1136/bmjopen-2021-054666.

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ObjectiveTo describe the distribution of consultations at the practice level and examine whether increases are uniform or driven by people who consult more frequently.DesignRetrospective cohort study.SettingUK general practice data from the Clinical Practice Research Datalink (CPRD) GOLD database.Participants1 699 709 314 consultation events from 12 330 545 patients, in 845 general practices (1 April 2000 to 31 March 2019).MethodsConsultation information was aggregated by financial year into: all consultations/all staff; all consultations/general practitioners (GPs); face-to-face consultations

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Fletcher, Stephen, Michael Strong, and Anthony Villar. "An Investigation of the Effects of Variations in Mentor-Based Induction on the Performance of Students in California." Teachers College Record: The Voice of Scholarship in Education 110, no. 10 (2008): 2271–89. http://dx.doi.org/10.1177/016146810811001003.

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Background/Context Policy makers are concerned about teacher shortages and the high rate of attrition among new teachers. Mentor-based induction has been shown to reduce the numbers of new teachers leaving schools or the profession. However, staying in the profession does not mean that new teachers are effective in helping students learn. Purpose/Objective/Research Question/Focus of Study The purpose of the project was to study how variations in new teacher support programs are related to changes in student achievement. Research Design Three districts that had participated in the New Teacher C

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Huang, Lyndon G., Juquan Song, Kassandra K. Corona, et al. "735 Early Treatment with NSAIDs Improves Blood Clotting Function in Severely Burned Patients." Journal of Burn Care & Research 43, Supplement_1 (2022): S173—S174. http://dx.doi.org/10.1093/jbcr/irac012.288.

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Abstract Introduction The risk of coagulopathy is increased in severe burns. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed in burn patients to relieve pain and reduce inflammation. This study investigates the impact of NSAIDs on burn induced coagulopathy in severely burned patients. Methods Severe burn patients (total body surface area [TBSA] &gt;20%) were identified with TriNetX, a North American federated health research network from 51 health-care organizations (HCOs) and categorized for those receiving NSAIDs during the first week following injury; those with NS

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Mathiasen, R. "First Report of Durangan Dwarf Mistletoe, Arceuthobium vaginatum subsp. durangense, on Pinus cooperi and P. engelmannii in Mexico." Plant Disease 91, no. 9 (2007): 1201. http://dx.doi.org/10.1094/pdis-91-9-1201a.

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The Durangan dwarf mistletoe (Arceuthobium vaginatum subsp. durangense Hawksw. & Wiens, Viscaceae) parasitizes several species of pines (Pinus spp., Pinaceae) in the Mexican states of Durango, Sinaloa, and Jalisco (1,3). This mistletoe has primarily been reported from the western edge of the Sierra Madre Occidental in eastern Sinaloa and western Durango, but its distribution there is not well documented (3). In March 2007, I found Durangan dwarf mistletoe parasitizing Pinus engelmannii Carr., approximately 25 km north of Mexico Route 40 (24°00′51″N, 105°26′48″W, elevation 2,200 m), and on

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Lipinska, Wiktoria, Katarzyna Grochowska, Jakub Karczewski, Emerson Coy, and Katarzyna Siuzdak. "Catalytic Activity of Au-Cu Alloy on TiO₂ Nanotubes for Alcohol Oxidation." ECS Meeting Abstracts MA2023-02, no. 47 (2023): 2327. http://dx.doi.org/10.1149/ma2023-02472327mtgabs.

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First fuel cell was discovered 180 years ago and still the ideal, namely cheap and effective catalytic materials are highly required. Such device allows to convert chemical energy into electrical one without pollutant gasses emission. In the case of alcohol fuel cells, methanol, ethanol, ethylene glycol and glycerine are considered as a power source. Platinum is commonly used for alcohol electrocatalyst, because of its high activity and stability. However, due to the high cost and limited supply platinum should be replaced by material that small amount is enough to reach satisfactory catalytic

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Chorna, V. V., S. S. Khliestova, V. M. Podolian та ін. "Діагностика психічного стану здобувачів вищої медичної освіти як основна детермінанта їх професійного самовизначення". Ukrainian Journal of Military Medicine 3, № 3 (2022): 71–82. http://dx.doi.org/10.46847/ujmm.2022.3(3)-071.

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Мета роботи полягає у проведенні діагностики психічного стану здобувачів вищої медичної освіти за адаптованою методикою Г. Айзенка для узагальнення їх професійного самовизначення під час фахової підготовки, гендерні особливості діагностичних показників їхніх особистісних якостей та адаптивності до навчання. Матеріали та методи. Вивчали соціально-психологічні і психологічні характеристики кандидатів на навчання ЗВО за допомогою методики вивчення темпераменту (за опитувальником Г. Айзенка) та методики діагностики самооцінки психічних станів (адаптований варіант методики Г. Айзенка) за прог

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Mathiasen, R., A. Sediles, and S. Sesnie. "First Report of Arceuthobium hondurense and Sruthanthus deppeanus in Nicaragua." Plant Disease 90, no. 11 (2006): 1458. http://dx.doi.org/10.1094/pd-90-1458c.

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The Honduran dwarf mistletoe, Arceuthobium hondurense Hawksw. & Wiens (Viscaceae), is one of the rarest dwarf mistletoes known in Central America (1,2). It is only known from four general areas in Honduras, but has also been reported from three locations in southern Mexico (2,3). At one time, A. hondurense was thought to be in danger of extinction (1). During March 2006, we found three new populations of this rare dwarf mistletoe in the Cordillera Dipilto in northern Nicaragua (Department Nueva Segovia). One population was approximately 11 km northeast of San Fernando (13°44′55″N, 86°19′07

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Madero Velázquez, L., P. Zapater, C. Mira, et al. "P493 Do antiTNF or Ustekinumab trough levels correlate with joint extraintestinal manifestations activity in Inflammatory bowel disease patients?" Journal of Crohn's and Colitis 18, Supplement_1 (2024): i984—i985. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0623.

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Abstract Background Inflammatory spondyloarthritis(SpA) are the most common extraintestinal manifestations (EIM) associated to inflammatory bowel disease (IBD), with a prevalence of 20-50% for axial SpA(axSpA) and 5-20% for peripheral(pSpA). AntiTNF is the optimal therapy in axSpA intolerant or refractory to NSAIDs, also effective in pSpA. An optimal trough level has not been yet established in this clinical setting. Aim, to evaluate the correlation between antiTNF and UST trough levels and joint EIM activity in IBD patients. Methods Prospective, multicenter,cohort study. IBD patients diagnose

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Liu, Jie, Seth Wallerstein, Michael Conry, et al. "Abstract 3812: Characterization of cancer predisposition among germline variant carriers." Cancer Research 85, no. 8_Supplement_1 (2025): 3812. https://doi.org/10.1158/1538-7445.am2025-3812.

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Abstract Introduction: Identifying individuals with pathogenic or likely pathogenic germline variants in cancer-predisposition genes (PGV carriers) enables enhanced screening, chemoprevention, risk-reducing surgery and access to targeted therapies. Many such genes are linked to multiple cancers but the full-spectrum of cancer susceptibility among PGV carriers remains poorly understood and largely based on studies in high-risk populations. Here we sought to more accurately characterize the magnitude and spectrum of solid tumor risk among PGV carriers in population cohorts. Methods: We profiled

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Milowsky, Matthew I., Matthew D. Galsky, Johannes Alfred Witjes, et al. "Adjuvant nivolumab (NIVO) vs placebo (PBO) for high-risk muscle-invasive urothelial carcinoma (MIUC): Additional efficacy outcomes including overall survival (OS) in patients (pts) with muscle-invasive bladder cancer (MIBC) from CheckMate 274." Journal of Clinical Oncology 43, no. 5_suppl (2025): 658. https://doi.org/10.1200/jco.2025.43.5_suppl.658.

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658 Background: In the phase 3, randomized, double-blind CheckMate 274 trial, adjuvant NIVO demonstrated statistically signiﬁcant and clinically meaningful disease-free survival (DFS) beneﬁt vs PBO in pts with high-risk MIUC after radical surgery (RS) ± prior neoadjuvant cisplatin-based chemotherapy (NAC). With extended 3-y median follow-up, continued improvements in DFS were seen with NIVO vs PBO in the primary efficacy populations (intent-to-treat [ITT], tumor programmed death ligand 1 [PD-L1] expression ≥ 1%) and in pts with MIBC. Early trends in interim OS favored NIVO vs PBO in ITT and tu

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Xie, Xuemei, Marwa Manai, Jon A. Fuson, et al. "Abstract P4-08-01: Targeting CDK7 enhances the antitumor efficacy of enzalutamide in androgen receptor-positive triple-negative breast cancer." Cancer Research 83, no. 5_Supplement (2023): P4–08–01—P4–08–01. http://dx.doi.org/10.1158/1538-7445.sabcs22-p4-08-01.

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Abstract Background: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer. Among TNBC subtypes, the luminal androgen receptor (LAR) subtype expresses high levels of androgen receptor (AR), tends to be less proliferative, and generally responds poorly to neoadjuvant therapy. Previous studies have shown that AR inhibition suppressed proliferation of AR+ or LAR subtype TNBC cells and tumor growth in xenograft models. Thus, AR is a promising therapeutic target for this TNBC subtype. Here, we identified kinase targets for enhancing the antitumor efficacy of the AR inhibito

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Pipe, Steven, Paul van der Valk, Peter Verhamme, et al. "Long-Term Bleeding Protection, Sustained FIX Activity, Reduction of FIX Consumption and Safety of Hemophilia B Gene Therapy: Results from the HOPE-B Trial 3 Years after Administration of a Single Dose of Etranacogene Dezaparvovec in Adult Patients with Severe or Moderately Severe Hemophilia B." Blood 142, Supplement 1 (2023): 1055. http://dx.doi.org/10.1182/blood-2023-187624.

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Introduction: Etranacogene dezaparvovec (formerly AMT-061) is the first approved gene therapy for hemophilia B in the US and Europe. It is an adeno-associated virus serotype 5 (AAV5) vector containing a codon-optimized, highly active factor IX (FIX) Padua R338L transgene under the control of the liver-specific promoter LP-1. The pivotal phase 3 HOPE-B clinical trial (NCT03569891) of etranacogene dezaparvovec demonstrated superiority of bleeding protection compared to standard of care FIX prophylaxis up to 24 months post-treatment; long-term follow-up from Year 2 post-administration onward is c

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Kawashiri, S. Y., Y. Endo, A. Nishino, et al. "FRI0098 ASSOCIATION BETWEEN THE SEROLOGIC STATUS OF ISOTYPE-SPECIFIC AUTOANTIBODIES AND THERAPEUTIC EFFICACY IN RHEUMATOID ARTHRITIS PATIENTS TREATED WITH ABATACEPT: A PROSPECTIVE ULTRASOUND COHORT STUDY IN JAPAN." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 628.1–628. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2269.

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Background:The presence of anti-cyclic citrullinated protein antibodies (ACPA) and anti-carbamylated protein (anti-CarP) antibody is specific for rheumatoid arthritis (RA). Recently, it was reported that the serological status of ACPA is associated with the therapeutic response of the T-cell co-stimulation blocker abatacept (1, 2). However, it is currently unclear whether the serological status of each isotype levels of these autoantibodies before treatment introduction or the changes during treatment are associated with the therapeutic response of abatacept.Objectives:To evaluate longitudinal

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Harty, T., D. Dahly, S. Costelloe, M. O’ Shaughnessy, and S. Harney. "AB0335 INCIDENT CHRONIC KIDNEY DISEASE IN PATIENTS WITH RHEUMATOID AND PSORIATIC ARTHRITIS – A COMPARATIVE ANALYSIS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1350.2–1351. http://dx.doi.org/10.1136/annrheumdis-2023-eular.5818.

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BackgroundPatients with inflammatory joint conditions have a high prevalence of comorbidities including chronic kidney disease (CKD) [1]. The data pertaining to CKD in rheumatoid arthritis (RA) is limited [2], however and its association with psoriatic arthritis (PsA) remains unclear. Renal disease in RA and PsA is clinically important as it can lead to restrictions in the management of the primary disease, and is also associated with increased all-cause morbidity and mortality [3].ObjectivesTo determine and compare the rate of incident CKD in patients with rheumatoid and psoriatic arthritis a

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Krönke, Jan, Richard Schlenk, Kai-Ole Jensen, et al. "Identification of Clinically Relevant Predictive MRD Checkpoints in AML Patients with NPM1 Mutations: A Study of the AML Study Group (AMLSG)." Blood 114, no. 22 (2009): 1586. http://dx.doi.org/10.1182/blood.v114.22.1586.1586.

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Abstract Abstract 1586 Poster Board I-612 Background Mutations in the nucleophosmin 1 (NPM1) gene represent the most frequent gene mutations in acute myeloid leukemia (AML), with highest frequency (50-60%) in cytogenetically normal (CN)-AML. Several studies have shown the applicability and prognostic value of an NPM1 mutation (NPM1mut)-based assay for detection of minimal residual disease (MRD). So far, there are no studies evaluating the prognostic value of NPM1mut MRD levels in a large controlled cohort of AML patients (pts) enrolled on prospective clinical trials. Aims To evaluate the progn

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Grafinger, Christine Maria. "nr="313"Daniela Mondini, Carola Jäggi und Peter Cornelius Claussen, Die Kirchen der Stadt Rom im Mittelalter 1050-1300, Bd. 4: M-O. SS. Marcellino e Pietro bis S. Omobono, mit Beiträgen von Peter Cornelius Claussen, Carola Jäggi, Almuth Klein, Giorgia Pollio, Alexander Racz, Michael Schmitz, Darko Senekovic und Angela Yorck von Wartenburg. Corpus Cosmatorum II, 4. Forschungen zur Kunstgeschichte und christlichen Archäologie. 23. Stuttgart: Franz Steiner Verlag, 2020, S. 709, 492 Abb., 51 Farbtafeln." Mediaevistik 33, no. 1 (2020): 313–14. http://dx.doi.org/10.3726/med.2020.01.45.

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McIntyre, Matthew, Barry Cheaney, Jesse Jia-Xin Liu, Aclan Dogan, and Olabisi Sanusi. "709 Establishment of an Early ICU De-escalation Pathway Using the Modified Frailty Index Among Angiogram-Negative Subarachnoid Hemorrhage Patients." Neurosurgery 70, Supplement_1 (2024): 164. http://dx.doi.org/10.1227/neu.0000000000002809_709.

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INTRODUCTION: Angiogram-negative subarachnoid hemorrhage (ANSAH) may have a benign clinical course. Our standard practice is to observe ANSAH patients for a prolonged period in the ICU. Previous work has established frailty as a strong predictor of ANSAH outcomes. METHODS: A retrospective cohort analysis was performed among patients admitted between 2011 and 2022 with non-traumatic subarachnoid hemorrhage and initial angiogram (DCA) negative for source. Primary endpoints were in-hospital complications, discharge home, and length-of-stay (LOS). Cost analysis was performed using hospital charges

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Ансарін Алі Акбар та Джаваді Шалал. "Маскований семантичний/ асоціативний та перекладний праймінг у різних мовах". East European Journal of Psycholinguistics 5, № 1 (2018): 7–15. http://dx.doi.org/10.29038/eejpl.2018.5.1.ans.

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Статтю присвячено спробі дослідити двомовний ментальний лексикон. Головне питання дослідження – встановити, чи персько-англійські білінгви можуть досягнути ефекту семантичного / асоціативного або перекладацького праймінгу. Для відповіді на це питання було застосовано масковану праймінгову парадигму як техніку, що відображає автоматичні когнітивні процеси, що тривають під час семантичної обробки, а не стратегічного використання прайму. Із метою вирішення лексичного завдання було сформовано чотири типи цільових пар праймінгу (перекладацькі еквіваленти, семантично подібні, асоціативно та семантич

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Specchia, Giorgina, Patrizia Pregno, Maura Nicolosi, et al. "Chronic Myeloid Leukemia Italian Multicenter Observational Study (CML-IT-MOS): Clinical Characteristics of Chronic Myeloid Leukemia (CML) Patients Treated in Real-Life between 2012 and 2016 in 66 Italian Hematology Centers of the Gimema Study Group." Blood 132, Supplement 1 (2018): 45. http://dx.doi.org/10.1182/blood-2018-99-116648.

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Abstract Background: The advent of Tyrosine Kinase Inhibitors (TKI) totally changed the outcome of patients affected by Chronic Myeloid Leukemia (CML). Most of informations about the clinical characteristics of CML patients are based on data derived from clinical trials, that often exclude patients not fitting with strict inclusion criteria. In real life may be important to know the characteristics of the entire CML patients' population and this is better reflected by registries studies including all consecutive patients. Aim: To provide a robust and updated information on clinical, hematologi

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Jang, Jun Ho, Ji-Hyun Kim, Kyungah Lee, Eugene Kim, Hyojin Kim, and Fangyuan Wang. "Red Blood Cell Transfusion Dependence Is Associated with Greater Healthcare Resource Utilization, Higher Medical Cost, and Poorer Prognosis in Patients with Lower-Risk Myelodysplastic Syndromes: A 28-Year Retrospective Observation Study Result." Blood 142, Supplement 1 (2023): 1869. http://dx.doi.org/10.1182/blood-2023-173351.

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Myelodysplastic syndromes (MDS) encompass a heterogeneous group of myeloid neoplasms characterized by cytopenia due to inefficient hematopoiesis, with a considerable risk of progression to acute myeloid leukemia (AML) or early mortality. In lower-risk MDS (LR-MDS) patients, anemia and its associated complications have been the focus of clinical attention. A significant portion of these patients eventually develop red blood cell transfusion dependence (RBC TD), which has been linked to a poorer prognosis. Given the limited efficacy of available treatments in reducing RBC TD, most patients face

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Terpos, Evangelos, Dimitrios Christoulas, Maria Gkotzamanidou, et al. "Circulating Levels of the Wnt Inhibitors Dickkopf-1 and Sclerostin In Different Phases of Multiple Myeloma: Alterations Post-Therapy with Lenalidomide and Dexamethasone with or without Bortezomib." Blood 116, no. 21 (2010): 2963. http://dx.doi.org/10.1182/blood.v116.21.2963.2963.

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Abstract Abstract 2963 Dickkopf-1 (Dkk-1) and sclerostin are inhibitors of the Wingless-type and integrase 1 (Wnt) signaling and they are implicated in the pathogenesis of multiple myeloma (MM) bone disease through inhibition of osteoblast function. There is very limited information for the circulating levels of Dkk-1 and sclerostin in different phases of MM and their alterations post therapies with novel agents. Therefore, we studied 284 MM patients (153M/131F, median age 66 years): 167 consecutive patients were newly-diagnosed (20 had asymptomatic MM and 147 symptomatic MM), 29 patients were

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Kubica, Claudia, Sascha Ketelhut, and Claudio R. Nigg. "Effects of a training intervention tailored to the menstrual cycle on endurance performance, recovery and well-being in female recreational runners – A randomized-controlled pilot study." Current Issues in Sport Science (CISS) 8, no. 2 (2023): 026. http://dx.doi.org/10.36950/2023.2ciss026.

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Introduction Female endurance athletes, such as runners, show a high prevalence of menstrual cycle (MC) related symptoms and diseases (Dusek, 2001). Almost one in four runners and 65% of long-distance runners are suffering from secondary amenorrhea (Dusek, 2001) and consecutive symptoms, such as an increased risk of injury, reduced bone mass, and a higher risk for cardiovascular diseases (Ihalainen et al., 2021). Causes for MC-related symptoms or diseases are multifactorial but in sports, a relationship to the training load, recovery, and sufficient energy availability exists (Redman & Lou

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Maritza, Erra Khanza, and Berliana Widi Scarvanovi. "The Effect of “Si Andi” Flashcard Games on Improving Personal Safety Skills." JPUD - Jurnal Pendidikan Usia Dini 18, no. 1 (2024): 112–28. http://dx.doi.org/10.21009/jpud.181.08.

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One of the highest and continually increasing phenomena of violence in Indonesia is sexual abuse. The most frequent victims of this phenomenon are early childhood. The purpose of this study is to determine the influence of the "SI ANDI - Siap Amankan Diri” (Ready to Protect Yourself) flashcard games on improving personal safety skills in early childhood. This study involved 40 subjects aged 4-6 years, divided into control and experimental groups (n=20 for each group). This research is a quasi-experimental study with a non-equivalent control group design. Assessment of personal safety skills em

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Haimi, Yoram. "Naḥal Ẓena‘, Survey". Hadashot Arkheologiyot - Excavations and Surveys in Israel, 28 квітня 2011. https://doi.org/10.69704/jhaesi.116.2004.1654.

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During July 2008, a survey was conducted near a farm in the region of Nahal Zena' (License No. S-51/2008; map ref. 17658-709/51713-42), following a request to increase the size of the farm. The survey, undertaken on behalf of the Israel Antiquities Authority and underwritten by Mr. Y. Adler, was directed by Y. Haimi.

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Krhut, Jan, Pavel Hradílek, Adéla Kondé, et al. "Analysis of the onset of lower urinary tract symptoms in multiple scleroris patients." World Journal of Urology 43, no. 1 (2025). https://doi.org/10.1007/s00345-025-05709-y.

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Abstract Purpose To estimate the timepoint of onset of the lower urinary tract symptoms (LUTS) over the course of multiple sclerosis (MS), determine which of the LUTS typically appears first, and identify risk factors for early development of LUTS in patients with MS (PwMS). Methods This observational study included 1167 PwMS. The participants were predominantly women (72%), median age was 45 (IQR 36;53) years, and median disease duration was 11 (IQR 6;16) years. Inclusion criteria were age over 18 years, proven MS diagnosis according to McDonald´s criteria (2017), and complete medical records

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Abderrahmane, Fatimetou, Gerald Raverot, Herve Lefebvre, et al. "SUN-714 Phenotype of Patients Carrying the c.709(-7-2)del PRKAR1A Mutation in a Large Cohort of 41 Patients." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.1395.

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Abstract Objective: The Carney Complex (CNC) is a multiple endocrine and non endocrine neoplasia, mostly due to PRKAR1A mutations. The PRKAR1A mutation c.709(-7-2)del located in the intron 7 is one of the three known hot spot. The objective of this study is to described the CNC manifestations presented by patients harboring the c.709(-7-2)del. Methods: This study is a multicenter retrospective longitudinal study. Patients data have been collected from medical files. Multicenter retrospective study. Age at the diagnosis or at the screening of the different CNC manifestations is described by mea

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Brédart, Anne, Jean-Luc Kop, Anja Tüchler, et al. "Assessment of psychosocial difficulties by genetic clinicians and distress in women at high risk of breast cancer: a prospective study." European Journal of Human Genetics, April 11, 2022. http://dx.doi.org/10.1038/s41431-022-01096-9.

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AbstractWe examined how often genetic clinicians correctly identify psychosocial difficulties in women at high breast cancer risk and explored effects of this assessment and the genetic test result on counselees’ distress. A prospective observational study of counselee–clinician dyads was performed in three French, German and Spanish genetic clinics, involving 709 counselees (participation rate, 83.4%) and 31 clinicians (participation rate, 100%). Counselee–clinician agreement in perceived psychosocial difficulties was measured after the pre-test genetic consultation. Multivariate mixed linear

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Ullah, Waqas, Harigopal Sandhyavenu, Amro Taha, et al. "Antiplatelet Strategy for Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention: A Systematic Review and Network Meta‐Analysis." Journal of the American Heart Association, October 11, 2024. http://dx.doi.org/10.1161/jaha.122.032490.

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Background Optimal duration and choice of antiplatelet therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention remain controversial. Methods and Results Digital databases (PubMed, Cochrane, and Embase) were queried to select all randomized controlled trials on a post–percutaneous coronary intervention population with acute coronary syndrome. Dual‐antiplatelet therapy (DAPT) with aspirin and clopidogrel for 12 months was compared with 4 major strategies: high‐potency, high‐ to low‐potency, low‐dose, and short‐duration DAPT. A network meta‐analysis was perf

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SETHI, BIPIN, RAKESH K. SAHAY, MANGESH H. TIWASKAR, et al. "889-P: Effectiveness of Dapagliflozin as Add-on to Metformin Alone or Metformin with Other Oral Antidiabetic Drug Classes in Type 2 Diabetes Mellitus—A Multicentre, Retrospective, Real-World Evidence Study." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-889-p.

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Background: Present real-world study evaluated the effectiveness of dapagliflozin as an add-on modality, in adult patients with T2DM. Method: We conducted an EMR-based retrospective, multicentre study in adult T2DM patients inadequately controlled on existing antidiabetic therapy and receiving dapagliflozin as add-on therapy. Baseline characteristics (visit 1) and treatment-related outcomes (visit 2 considered between 60 days-140 days after adding dapagliflozin) which included HbA1C, BMI, SBP & DBP were analyzed. Results: 3616 patients were included from 478 centres, of which 55.7% were ma

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