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Journal articles on the topic '711.553.9 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Effendy, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXVIII Synthesis and Structural Systematics of Some 1 : 3 Adducts of Silver(I) Compounds with Triphenylstibine, [(Ph3Sb)3AgX], X = Cl, I, SCN, NCS, CN, ONO2." Australian Journal of Chemistry 50, no. 6 (1997): 587. http://dx.doi.org/10.1071/c96035.

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The syntheses and room-temperature single-crystal X-ray structural characterization of 1 : 3 adducts formed between silver(I) (pseudo-) halides, AgX, and triphenylstibine, SbPh3, are described for X = Cl, I, SCN, NCS, CN, NO3 (1)-(6). The chloride, as its methanol solvate (1a), is isomorphous with the arsine analogue: triclinic, P-1, a 13·373(4), b 14·48(6), c 14·702(3) Å, α 83·49(3), β 87·76(2), γ 76·45(3)°; Z = 2, conventional R on F being 0·046 for No 5514 independent ‘observed’ reflections (I > 3σ(I )). A new form (1b) of the chloride has also been authenticated: monoclinic, P 21/c, a 1

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Harrowfield, Jack M., Raj Pal Sharma, Todd M. Shand, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. I 2-Nitrophenoxides of Group 1." Australian Journal of Chemistry 51, no. 8 (1998): 707. http://dx.doi.org/10.1071/c97098.

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Room-temperature, single-crystal X-ray studies are recorded for the variously hydrated Group 1 metal derivatives of 2-nitrophenol (2-npH = C6H5NO3). A provisional determination is reported for Li(2-np).½H2O, set as monoclinic, P21/c, a 3·535(3), b 15·06(1), c 24·42(2) Å, β 91·7(1)°, Z = 8, conventional R on F currently 0·18 for No 875 ‘observed’ (I > 3σ(I)) reflections. Na(2-np).H2O is monoclinic, C2/c, a 34 ·23(2), b 3·624(4), c 35·48(2) Å, β 91·24(4)°, Z = 24, R 0·060 for No 1371. Rb(2-np).½ H2O is monoclinic, C2/c (isomorphous with the previously determined potassium analogue), a 25·269(

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Bahl, M., M. Stöcker, S. Tsiami, X. Baraliakos, J. Braun, and U. Kiltz. "AB0587 THE RISK OF PATIENTS WITH POLYMYALGIA RHEUMATICA AND GIANT CELL ARTERITIS TO DEVELOP DIABETES AND OSTEOPOROSIS ON FOLLOW UP." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1419.2–1420. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2742.

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BackgroundPatients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are commonly treated with glucocorticoids (GC) in different dosages. Therefore, the most common comorbidities that may develop are osteoporosis (OPO) and diabetes mellitus (DM).ObjectivesTo study the development of these comorbidities in the management of PMR and GCA in a real-life setting.MethodsIn a retrospective study design, longitudinal data of patients with a clinical diagnosis of PMR and GCA treated in a tertiary center were studied. Patients and disease characteristics were documented according to clini

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Bektaş, M., S. Yüce, M. Ay, M. Uyar, M. Önder, and M. İ. Kiliç. "POS0555 HIGH DOSE INTRAVENOUS ANAKINRA TREATMENT IS SAFE AND EFFECTIVE IN SEVERE AND CRITICAL COVID-19 PATIENTS: A PROPENSITY SCORE MATCHED STUDY IN A SINGLE CENTER." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 544. http://dx.doi.org/10.1136/annrheumdis-2023-eular.339.

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BackgroundIn COVID-19 severe disease course such as need of intensive care unit (ICU) as well as development of mortality is mainly due to cytokine storm.ObjectivesIn this study, we aimed to evaluate the high dose intravenous anakinra treatment response and outcome in patients with severe and critical COVID-19 compared to standard of care.MethodsThis retrospective observational study was carried out at a tertiary referral center. The study population consisted of two groups as follows; the patients receiving high dose intravenous anakinra (anakinra group) between 01.09.2021 and 01.02.2022 and

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Chernov, S. V., S. E. Krasilnikov, J. A. Rzaev, et al. "Predominant localization and ways of metastatic dissemination to the brain of malignant tumors of the female reproductive system." Russian journal of neurosurgery 26, no. 2 (2024): 54–60. http://dx.doi.org/10.17650/1683-3295-2024-26-2-54-60.

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Background. Metastases of the female reproductive system cancer to the brain are rare and reach about 5 % of all cases with metastatic lesions of the central nervous system. The most common metastases are ovarian cancer (0.49–6.1 %), endometrial cancer (0.4–1.2 %) and cervical cancer (0.3–0.9 %). The predominant localization and ways of spreading metastases to the brain in this category of tumors may differ from lung cancer, breast cancer, kidney cancer or melanoma.Aim. To analyze the localization of brain metastases of malignant tumors of the female reproductive system and the ways of dissemi

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Bottinor, Wendy, Haoxue Xiang, Yan Chen, et al. "Cardiovascular risk factor severity and adverse cardiovascular events: A report from the Childhood Cancer Survivor Study (CCSS)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 12055. https://doi.org/10.1200/jco.2025.43.16_suppl.12055.

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12055 Background: Among survivors of childhood cancer, more severe grades of CVRFs are associated with increased risk for adverse cardiovascular events (ACE). The impact of low severity CVRFs has not been defined. Methods: Among 25,723 long-term survivors of childhood cancer, CVRF severity was graded using longitudinal self-report: Grade 1 conditions are reported but not on medications; Grade 2 are prescribed medications. Cumulative incidence of CVRFs were estimated into the 6 th decade of life with death and Grade 2 CVRFs a competing risk event for Grade 1 CVRFs. Starting at 1st report of a C

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Enright, Thomas L., Jacob B. Leary, Dimitra R. Bakaloudi, et al. "Abstract 3402: Number of variants of unknown significance (VUS) by next generation sequencing (NGS) and response to systemic therapies in advanced urothelial carcinoma (aUC)." Cancer Research 85, no. 8_Supplement_1 (2025): 3402. https://doi.org/10.1158/1538-7445.am2025-3402.

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Abstract Background: NGS is routinely used in aUC to identify clinically actionable alterations. NGS assays tier variants by the likelihood of clinical significance, reporting both pathogenic variants and VUS. The number of VUS may serve as a rough estimate for neoantigen load, e.g. tumor mutational burden (TMB). We hypothesized that the number of VUS may represent an easy-to-use biomarker associated with response and overall survival (OS) with certain therapies e.g. immune checkpoint inhibitors (ICI). Methods: We conducted a retrospective study from patients (pts) from a single academic cente

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Nemes, Karolina, Pascal D. Johann, Mona Steinbügl, et al. "ATRT-05. Infants and newborns with atypical teratoid/rhabdoid tumors (ATRT) and extracranial malignant rhabdoid tumors: a unique and challenging population." Neuro-Oncology 24, Supplement_1 (2022): i2—i3. http://dx.doi.org/10.1093/neuonc/noac079.004.

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Abstract INTRODUCTION: Malignant rhabdoid tumors (MRT) predominantly affect infants. Patients below six months represent a particularly challenging group: intensity of therapy is limited by toxicity to developing organs. Information on prognostic factors, toxicity and long term outcome is sparse. METHODS: Clinical, genetic, and treatment data of 100 patients (less than 6 months at diagnosis) from 13 European countries were analyzed (2005-2020). Tumors and matching blood samples were examined for SMARCB1 mutations using FISH, MLPA and Sanger sequencing. DNA-methylation subgroups (ATRT-TYR, ATRT

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Badjatia, Neeraj, Alice Ryan, H. Alex Choi, et al. "Relationship Between Nutrition Intake and Outcome After Subarachnoid Hemorrhage: Results From the International Nutritional Survey." Journal of Intensive Care Medicine 36, no. 10 (2021): 1141–48. http://dx.doi.org/10.1177/0885066620966957.

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Background: A previous study suggested an association between low caloric intake(CI), negative nitrogen balance, and poor outcome after subarachnoid hemorrhage(SAH). Objective of this multinational, multicenter study was to investigate whether clinical outcomes vary by protein intake(PI) or CI in SAH patients adjusting for the nutritional risk as judged by the modified NUTrition Risk in the Critically Ill (mNUTRIC) score. Methods: The International Nutrition Survey(INS) 2007-2014 was utilized to describe the characteristics, outcomes and nutrition use. A subgroup of patients from 2013 and 2014

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Park, Sang Hyun, Taek Sang Kim, Jae Young Joung, Sung Han Kim, and Jinsoo Chung. "Postoperative long-term prognosis of localized renal cell carcinoma after partial or radical nephrectomy: Analysis of cancer metastasis and deaths during a more than five-year follow-up." Journal of Clinical Oncology 37, no. 7_suppl (2019): 604. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.604.

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604 Background: We performed a long-term follow-up study to evaluate the survival and metastatic outcomes of non-metastatic renal cell carcinoma (RCC) after curative removal of tumor. Methods: We retrospectively reviewed the clinical and pathological features of 5434 patients with localized renal cell carcinoma admitted to five Korean tertiary-care institutions between 2000 and 2012, who had undergone curative surgeries with partial or radical nephrectomy with/without lymph nodal dissection. The patients below the age of 19 years (N=9) with benign histology (N=24), and with no follow-up record

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Etemad, Leila L., John K. Yue, Jason Barber, et al. "Longitudinal Recovery Following Repetitive Traumatic Brain Injury." JAMA Network Open 6, no. 9 (2023): e2335804. http://dx.doi.org/10.1001/jamanetworkopen.2023.35804.

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ImportanceOne traumatic brain injury (TBI) increases the risk of subsequent TBIs. Research on longitudinal outcomes of civilian repetitive TBIs is limited.ObjectiveTo investigate associations between sustaining 1 or more TBIs (ie, postindex TBIs) after study enrollment (ie, index TBIs) and multidimensional outcomes at 1 year and 3 to 7 years.Design, Setting, and ParticipantsThis cohort study included participants presenting to emergency departments enrolled within 24 hours of TBI in the prospective, 18-center Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) st

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Mashayekhi, Mona, Hui Nian, Sara E. Howard, et al. "LBSUN306 Effects Of Glp-1 Receptor Agonism, Dpp4 Inhibition, And Hypocaloric Diet On Metabolic Parameters In Obese Pre-diabetic Individuals: A Randomized-controlled Trial." Journal of the Endocrine Society 6, Supplement_1 (2022): A292—A293. http://dx.doi.org/10.1210/jendso/bvac150.603.

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Abstract Background GLP-1 receptor (GLP1R) agonists reduce glucose, weight and cardiovascular risk. Understanding the weight loss-dependent mechanisms of these benefits will inform treatment and drug development. This study compared metabolic responses among GLP1R agonist (liraglutide), DPP4 inhibitor (sitagliptin), and hypocaloric diet treatments. Methods We randomized 88 obese, pre-diabetic individuals in a 2: 1: 1 ratio to liraglutide, sitagliptin, or diet for 14 weeks. Treatment was double-blinded and placebo-controlled for drug. Individuals completed a mixed meal at baseline, 2 and 14 wee

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Giagounidis, Aristoteles, Alan F. List, Eva Hellstrom-Lindberg, et al. "Prevalence and Clinical Impact of Additional Cytogenetic Abnormalities in Patients (Pts) with Myelodysplastic Syndromes (MDS) and Deletion 5q from the MDS-003 and MDS-004 Studies." Blood 124, no. 21 (2014): 3270. http://dx.doi.org/10.1182/blood.v124.21.3270.3270.

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Abstract Introduction: Around 50% of pts with de novo MDS present with chromosomal abnormalities at diagnosis. One of the most common cytogenetic abnormalities in MDS, deletion 5q [del(5q)], occurs in ~15% of pts (Haase et al. Blood 2007;110:4385-95). The presence of cytogenetic abnormalities in addition to del(5q) may be associated with shorter overall survival (OS) and increased risk of progression to acute myeloid leukemia (AML) versus del(5q) alone (Mallo et al. Leukemia 2011;25:110-20). In 2 large multicenter studies (MDS-003 and MDS-004), lenalidomide (LEN) was evaluated in RBC transfusi

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Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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Sierra-Díaz, Diana Carolina, Adrien Morel, Dora Janeth Fonseca, et al. "Abstract P3-07-05: Genetic profile of germline mutations in unselected women with breast cancer in a Colombian population." Cancer Research 82, no. 4_Supplement (2022): P3–07–05—P3–07–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p3-07-05.

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Abstract Introduction In Colombia Breast cancer (BC), is the most frequent and has the highest mortality rate among all types of cancer. There are few studies of the genomic profile in unselected affected population by BC in Colombia. Some of these studies have only tested the presence of variants reported as founders named “Colombian Profile”.We conducted a large-scale genomic analysis using Whole Exome Sequencing (WES) to evaluate germline mutations in unselected BC patients. Methods This trial included 299 unselected BC female patients aged over 18 years old, without personal and family his

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Monteiro, Isabel Longo de Oliveira, Carolina Araújo Silva, Lígia Luana Freire da Silva, et al. "ÓBITOS POR NEOPLASIA DE PÊNIS: 2000 A 2023." Revista ft 29, no. 144 (2025): 02–03. https://doi.org/10.69849/revistaft/fa10202503262202.

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A neoplasia peniana, embora rara, é uma condição importante devido ao seu impacto na saúde masculina. O câncer de pênis é mais comum em países em desenvolvimento, com fatores de risco como infecção por HPV, fimose e higiene inadequada. O carcinoma espinocelular é o tipo histológico mais frequente. Quando diagnosticado precocemente, o prognóstico é mais favorável, com opções de tratamento que variam de ressecções locais a penectomia, dependendo do estágio da doença. OBJETIVOS: O objetivo do presente trabalho foi realizar o levantamento epidemiológico acerca dos óbitos por neoplasia de pênis, en

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Castrejon, I., J. Molina Collada, C. Perez-Garcia, et al. "POS1439 CANCER IN PATIENTS WITH RHEUMATIC DISEASES EXPOSED TO DIFFERENT BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN REAL-WORLD CLINICAL PRACTICE: DATA FROM A MULTICENTER REGISTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3834.

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BackgroundExtensive evidence has confirmed no increased risk of cancer associated to either conventional synthetic DMARDs or anti-TNF in patients with rheumatic diseases. The risk of cancer in biologic (bDMARDs) different to anti-TNF and targeted synthetic (tsDMARDs) is considerably less investigated. As new therapies are emerging, more data in real-world registries are needed to confirm safety in other treatment groups.ObjectivesTo compare the risk of cancer of tsDMARDs and other bDMARDs versus anti-TNF in patients with rheumatic diseases.MethodsData of patients enrolled in BIOBADASER 3.0 up

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Yardimci, G. K., E. Erul, B. Farisoğullari, et al. "AB0446 DEMOGRAPHIC AND CLINICAL FEATURES OF IDIOPATHIC INFLAMMATORY MYOSITIS AND PREVALENCE OF MYOSITIS-RELATED ANTIBODIES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1250.2–1251. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3349.

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Background:Idiopathic inflammatory myopathies (IIM) are heterogeneous groups of connective tissue diseases. Diagnosis of IIM is sometimes challenging, but newly defined myositis specific autoantibodies (MSAs) are helpful in diagnosing of IIM and revealing the clinical signs [1].Objectives:To describe demographic and clinical features of IIMs and to evaluate the frequency and clinical associations of myositis-specific and myositis associated antibodies (MAAs) in IIM.Methods:Samples obtained from patients tested for MSA/MAA as of 2017 to 2020 were retrospectively evaluated. Patients were diagnos

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Davydkin, Igor, Tatiana Andreeva, Vladimir Yu Zorenko, et al. "Safety and Efficiency of New Nonacog Alfa Drug in the Treatment of Bleeding Episodes in Patients with Severe and Moderate Hemophilia B." Blood 126, no. 23 (2015): 4690. http://dx.doi.org/10.1182/blood.v126.23.4690.4690.

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Abstract The efficiency and safety of a new Russian recombinant factor IX - FIX (nonacog alpha, Innonafactor®, GENERIUM) in prevention of bleeding episodes in patients with severe and moderate hemophilia B (part 1 of phase II-III clinical trial) were studied in a controlled randomized open prospective multicenter clinical trial in comparison with plasma derived FIX - Octanine® F (filtered) (Octapharmazeutika Produktionsges mbH, Austria). The main objective of this study was to test therapeutic equivalence and safety of nonacog alfa compared to Octanine F® in patients with severe and moderate h

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Furukawa, Shoko, Keiji Nogami, Tomoko Matsumoto, Ryu Kasai, and Midori Shima. "Pre-Analysis for Hemostatic Effect of Bypassing Agents in Hemophilia a Patients with Inhibitors Under the Emicizumab Prophylaxis By Global Assays." Blood 132, Supplement 1 (2018): 3793. http://dx.doi.org/10.1182/blood-2018-99-114355.

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Abstract Introduction: Emicizumab (Emi) is an anti-factor (F)IXa/FX bispecific antibody that mimics FVIIIa cofactor function. The clinical trials on Emi prophylaxis for hemophilia A patients with inhibitor (HA-Inh) demonstrated marked reduction in bleeding rates. However, Emi at clinically relevant plasma concentrations (~50 mg/ml) corresponding to ~15% of FVIII equivalent activity may not provide enough hemostasis at severe bleeding or major surgical intervention. In these circumstances, additional infusions of bypassing agents (BPAs) may be needed for hemostatic management. In the HAVEN 1 st

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Jones, H. N., V. Strand, H. Schulze-Koops, et al. "POS0652 SEX DIFFERENCES IN THE EFFICACY AND SAFETY OF TOFACITINIB IN RHEUMATOID ARTHRITIS PATIENTS: A POST HOC ANALYSIS OF PHASE 3 AND LONG-TERM EXTENSION TRIALS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 565–66. http://dx.doi.org/10.1136/annrheumdis-2021-eular.359.

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Background:Differences in efficacy outcomes favouring males vs females with rheumatoid arthritis (RA) have been reported with conventional synthetic (cs) disease-modifying antirheumatic drugs (DMARDs) and tumour necrosis factor inhibitors; results with Janus kinase inhibitors are less clear.Objectives:To assess the impact of sex on efficacy, safety and persistence in tofacitinib RA clinical trials.Methods:Efficacy and safety analyses included data pooled from Phase (P)3 randomised controlled trials (RCTs) of patients (pts) with RA and an inadequate response (IR) to methotrexate (NCT00847613; N

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Khodunova, Elena E., Elena N. Parovichnikova, Irina V. Galtzeva, Sergey M. Kulikov, and Valeri G. Savchenko. "Pro- and Antiapoptotic Proteins Expression on Bone Marrow and Peripheral Blood CD34+Cells in Acute Leukemia (AL) Patients." Blood 118, no. 21 (2011): 4996. http://dx.doi.org/10.1182/blood.v118.21.4996.4996.

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Abstract Abstract 4996 It was shown that drug resistance, poor-risk cytogenetics and poor prognosis in AL is associated with high level of Bcl-2 expression and low Bax/Bcl-2 ratio (<0,3). Fas-antigen (CD95) as a protein triggering the extrinsic apoptotic pathway is differently expressed on hematopoietic precursors. More immature CD34+/CD38- AML blast cells have lower expression of Fas/Fas-L and lower Fas-induced apoptosis than CD34+/CD38+cells. CD34+/CD38− leukemia precursors also have a reduced sensitivity to daunorubicin in vitro and increased expression of multidrug resistance genes (mrp

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Deodhar, A., D. Van der Heijde, L. S. Gensler, et al. "POS0939 BIMEKIZUMAB IN PATIENTS WITH ACTIVE NON-RADIOGRAPHIC AXIAL SPONDYLOARTHRITIS: 24-WEEK EFFICACY & SAFETY FROM BE MOBILE 1, A PHASE 3, MULTICENTRE, RANDOMISED, PLACEBO‑CONTROLLED STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 772–73. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2416.

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BackgroundBimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits IL-17F in addition to IL-17A. BKZ has shown rapid and sustained efficacy and was well tolerated up to 156 weeks (wks) in a phase 2b study in patients (pts) with active ankylosing spondylitis.1,2ObjectivesTo assess efficacy and safety of BKZ vs placebo (PBO) in pts with active non-radiographic axial spondyloarthritis (nr-axSpA) up to Wk 24 in the ongoing pivotal phase 3 study, BE MOBILE 1.MethodsBE MOBILE 1 (NCT03928704) comprises a 16-wk double-blind, PBO-controlled period and 36-wk maintenance period. Pts were

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Moral, K., E. Bilgin, O. Karadag та ін. "AB0943 EVALUATION OF THE EFFECT OF TUMOR NECROSIS FACTOR - Α THERAPY ON 24-HOUR AMBULATORY BLOOD PRESSURE MEASUREMENT AND SLEEP QUALITY IN PATIENTS WITH AXIAL SPONDYLOARTHRITIS". Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1689. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6219.

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BackgroundIncreased cardiovascular mortality has been reported in AS patients. There are studies showing the positive effects of anti-TNF-α therapy on both cardiovascular mortality and sleep quality. (1,2)ObjectivesTo determine the changes in sleep quality and 24-hour blood pressure readings in patients with axial spondiloarthritis (axSpA) after treatment with anti- tumor necrosis factor TNF-α therapy.MethodsPatients with axSpA who were admitted to Hacettepe University Hospital Rheumatology outpatient clinic between 01.03.2021 and 01.12.2021, anti-TNF-naive and without a history of cardiovascu

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Diamond, Akiva, Sabarish Ayyappan, Shufen Cao, et al. "Development of a Risk Score for Cardiovascular Events in Anthracycline Treated DLBCL Patients." Blood 138, Supplement 1 (2021): 2536. http://dx.doi.org/10.1182/blood-2021-153862.

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Abstract Introduction: There is increased risk of congestive heart failure (CHF) following anthracycline-based chemotherapy in patients with Diffuse Large B-cell lymphoma (DLBCL). Other than increased cumulative anthracycline dose, little is known about risk factors for developing CHF and other cardiovascular events (CVE). Methods: We conducted a retrospective analysis of 539 DLBCL patients diagnosed at University Hospitals Seidman Cancer Center between 2002 - 2016. Baseline patient and disease characteristics, patterns of treatment and outcomes after therapy, including response, survival, rel

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Dumas, Pierre-Yves, Sarah Bertoli, Clémence Santana, et al. "Real-World Multicenter Comparison of Venetoclax and Azacitidine Versus Intermediate or High Dose Cytarabine-Based Salvage for Patients with AML in First Relapse after Front Line Intensive Chemotherapy. a Dataml-IPC-Auraml Consortium Study." Blood 144, Supplement 1 (2024): 4275. https://doi.org/10.1182/blood-2024-210596.

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Introduction: Prognosis in relapsed acute myeloid leukemia (AML) patients (pts) is dismal, with no standard chemotherapy. Intermediate (I) or high (H)-dose cytarabine (DAC)-based regimens are common salvage treatments (Döhner, Blood 2022) leading to around 50% CR/CRi (Megías-Vericat, AJH 2018). Venetoclax (VEN)-azacitidine (AZA) is a front-line standard of care for unfit pts but is also widely used in pts with molecular relapse, primary induction failure (PIF) or morphologic relapse (Rel). In this study, we report the largest cohort of pts with AML treated with VEN-AZA compared to salvage I/HD

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Vahid, Danesh, Ozcan Numan та Najafi Mojtaba. "The evaluation of Isolated KH1-29 properties for producing α-amylase from a novel native highly thermostable, thermophilic and alkaline Bacillus sp". Biolife 3, № 2 (2022): 571–75. https://doi.org/10.5281/zenodo.7270814.

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<strong>ABSTRACT</strong> Alkaliphilic and thermophilic <em>bacillus sp</em>. KH1-29 which was isolated from Caspian Lake of Iran, produced thermostable α-Amylase at 55°C, pH 8.0. The molecular weight of the enzyme was estimated 45 kilodallton using sodium dodecyl sulphate-polyacrylamide gel electrophoresis. The enzyme showed working pH range of 7-8 with an optimum pH of 8.0. The temperature optimum of the enzyme was found at 90°C. α-Amylase production by Thermophilic <em>bacillus sp</em>. strain reached to maximum quantity at 36h after cultivation analyzed according to the

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Квітіньйо Макарена Мартінез, Соріано Федеріко Ґонзало, Яйченко Вірджинія, Стіб Бренда, and Барейро Хуан Пабло. "Predictors of Picture Naming and Picture Categorization in Spanish." East European Journal of Psycholinguistics 6, no. 1 (2019): 6–18. http://dx.doi.org/10.29038/eejpl.2019.6.1.cui.

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The aim of this paper was to identify which psycholinguistic variables are better predictors of performance for healthy participants in a picture naming task and in a picture categorization task. A correlation analysis and a Path analysis were carried out. The correlation analysis showed that naming accuracy and naming latency are significant and positively correlated with lexical frequency and conceptual familiarity variables, whereas they are negatively correlated with H index. Reaction times in the categorization task were negatively correlated with lexical frequency and conceptual familiar

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Ullah, Zia, Imran Hassan, Ishfaq Ahmed Hafiz, and Nadeem Akhtar Abbasi. "Effect of different priming treatments on seed germination of sago palm (Cycas revoluta L.)." World Journal of Biology and Biotechnology 5, no. 1 (2020): 1. http://dx.doi.org/10.33865/wjb.005.01.0237.

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King sago palm or sago cycas are the other name of Kangi palm (Cycas revoluta) sago palm has been used as an indoor and outdoor landscape plant for centuries. The present study was conducted to estimate the effect of different priming treatments on seed germination of sago palm (Cycas revoluta L.) in the research area of Department of Horticulture PMAS, University of Arid Agriculture Rawalpindi, Pakistan. The Experiment consisted of ten treatments; the seeds without pulp were soaked in solution of 500, 750 and 1000 ppm GA3 and 2%, 3% and 4% solution of KNO3 for 24 hr at room temperature. In ca

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Endrika, Sujarwo, and Said Suhil Achmad. "Relationship between Socio-Economic Status, Interpersonal Communication, and School Climate with Parental Involvement in Early Childhood Education." JPUD - Jurnal Pendidikan Usia Dini 14, no. 2 (2020): 361–78. http://dx.doi.org/10.21009/jpud.142.14.

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Parental Involvement in their children's schooling has long been recognized as a critical component of good education. This study aims to find out the relationship between socioeconomic status, interpersonal communication, and school climate with parental involvement in early childhood education. Using survey and correlational research design, data collection was carried out through accumulation techniques with tests and questionnaires. The data analysis technique used statistical analysis and multiple regressions. The findings in the socio-economic context of parents show that the measure of

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Oliver, Tucker A., Matthew L. Lee, Keaton F. Piper, M. Salman Ali, and Fernando L. Vale. "Surgery for mesial temporal pathology: a 26-year experience." Journal of Neurosurgery, May 1, 2025, 1–10. https://doi.org/10.3171/2025.1.jns242375.

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OBJECTIVE Mesial temporal lobe (MTL) surgery continues to be challenging to the novice surgeon. The aim of this study was to understand the nuances of MTL surgery using a keyhole craniotomy via an inferior temporal gyrus (ITG) access corridor. In addition, the authors reviewed associated complications and considered strategies for prevention. METHODS A single-surgeon IRB-approved database for epilepsy surgery was established in 1998, and cases from 1998 to 2022 were reviewed. After patients with high-grade gliomas with extensive temporal extension were excluded due to their extensive comorbidi

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Takagi, Ayako, Yoshiki Kusunoki, Mana Ohigashi, et al. "Association between continuous glucose monitoring-derived glycemic control indices and urinary biomarkers of diabetic kidney disease: Hyogo Diabetes Hypoglycemia Cognition Complications study." Acta Diabetologica, November 25, 2023. http://dx.doi.org/10.1007/s00592-023-02214-9.

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Abstract Aims Glomerular damage and proximal tubular damage play an important role in the pathogenesis of diabetic kidney disease. This study aimed to investigate the relationship between the urinary markers of proximal tubular injury, including urinary liver-type fatty acid-binding protein-to-creatinine ratio (uL-FABP/Cr) and urinary N-acetyl-β-d-glucosaminidase-to-creatinine ratio (uNAG/Cr), and glycemic control status. Methods This cross-sectional study included 245 and 39 patients with type 2 diabetes mellitus (T2DM) and non-T2DM (NDM), respectively. The participants of this study were fit

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Adams, Emma K., Kevin Murray, Stewart G. Trost, and Hayley Christian. "Longitudinal effects of dog ownership, dog acquisition, and dog loss on children’s movement behaviours: findings from the PLAYCE cohort study." International Journal of Behavioral Nutrition and Physical Activity 21, no. 1 (2024). http://dx.doi.org/10.1186/s12966-023-01544-9.

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Abstract Introduction Regular physical activity is important for children’s physical and mental health, yet many children do not achieve recommended amounts of physical activity. Dog ownership has been associated with increased physical activity in children, however, there have been no longitudinal studies examining this relationship. This study used data from the Play Spaces and Environments for Children’s Physical Activity (PLAYCE) cohort study to examine the longitudinal effects of dog ownership status on children’s movement behaviours. Methods Change in dog ownership from preschool (wave 1

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Bird, J., K. Morant, G. Kane, R. Mccully, P. Pellikka, and S. A. Luis. "1678 Impact of anemia in exercise stress echocardiography: effects on exercise capacity and stress testing safety." European Heart Journal - Cardiovascular Imaging 21, Supplement_1 (2020). http://dx.doi.org/10.1093/ehjci/jez319.1042.

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Abstract Funding Acknowledgements None Background/Purpose: Anemia is a common condition in patients with cardiovascular disease. The effect of anemia in exercise stress testing has not been evaluated in a large cohort of patients. Methods We performed a retrospective review of patients undergoing exercise stress echocardiography over a 10 year period who had blood hemoglobin assessed within 48 hours of stress testing. World Health Organization cutoffs were used in defining the degree of anemia. The effect of anemia on exercise capacity and stress testing safety outcomes was assessed. Results I

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Vatsa, Nishant, Puja K. Mehta, Laura P. Kimble, Melinda Higgins, and Arshed A. Quyyumi. "Abstract 11723: Depression and Obesity Are Associated with Chest Pain in Patients with Non-Obstructive Coronary Artery Disease." Circulation 144, Suppl_1 (2021). http://dx.doi.org/10.1161/circ.144.suppl_1.11723.

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Introduction: Chest pain in patients with non-obstructive coronary artery disease (NO-CAD) is a major clinical problem impacting the quality of life and can present a therapeutic challenge for providers. The objective of this study was to identify clinical factors associated with chest pain frequency in NO-CAD patients. Mainly, we investigated the hypothesis that increased body mass index (BMI) and depression are associated with increased chest pain frequency in NO-CAD patients. Methods: We identified a sample of 439 patients with NO-CAD (mean age 55.3 years, 50% women, 72% white) in the Emory

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Floyd, James S., Susan R. Heckbert, Noel S. Weiss, David S. Carrell, and Bruce M. Psaty. "Abstract 054: The Use of Administrative Data and Natural Language Processing to Estimate the Incidence of Statin-related Rhabdomyolysis." Circulation 125, suppl_10 (2012). http://dx.doi.org/10.1161/circ.125.suppl_10.a054.

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Introduction: Despite the problem of misclassification, many studies of adverse drug reactions (ADRs) rely on administrative data rather than events validated by medical record review. Hypothesis: We evaluated the new ICD-9 code for rhabdomyolysis (728.88) and natural language processing (NLP) as methods to identify cases of statin-related rhabdomyolysis, and estimated the incidence with various statins and doses. Methods: We conducted a population-based study of statin users in a health maintenance organization in Washington State from 2006-2010. Trained abstractors reviewed the medical recor

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Johnston, Karissa M., Katherine M. Osenenko, Bonnie M. Donato, et al. "Abstract 162: Treatment Patterns and Health Resource Utilization among Patients with Atrial Fibrillation in United Arab Emirates and Saudi Arabia." Circulation: Cardiovascular Quality and Outcomes 7, suppl_1 (2014). http://dx.doi.org/10.1161/circoutcomes.7.suppl_1.162.

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Objectives: Atrial fibrillation (AF) is the most common cardiac arrhythmia, and accounts for one-third of hospitalizations for cardiac disturbances. The majority of data on management of AF patients are from western countries, with limited information available from the Middle East region. The objective of this study was to characterize treatment patterns and health resource utilization among AF patients in the Kingdom of Saudi Arabia (KSA) and United Arab Emirates (UAE). METHODS: A retrospective chart review was undertaken at three hospitals in UAE and three in KSA, to identify AF patients di

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Miller, N., R. Rahav Koren, H. Shalev-Ram, H. Gluska, and A. Wiser. "P-779 18-year follow-up of 609 children born after oocyte donation: comparison with IVF and spontaneous conception based on a national health registry." Human Reproduction 40, Supplement_1 (2025). https://doi.org/10.1093/humrep/deaf097.1083.

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Abstract Study question To evaluate long-term health outcomes in children born after oocyte donation compared to children born after in vitro fertilization with autologous oocytes and spontaneous conception. Summary answer Children born after oocyte donation (OD) may have an increased risk of immune diseases and anxiety disorders compared to spontaneous conception (SC). What is known already Oocyte donation has advanced considerably since the first pregnancies from oocyte and embryo donation were reported nearly four decades ago. While perinatal outcomes of children born from oocyte donation p

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Ebbehoj, Andreas, Ravinder J. Kaur, Dingfeng Li, et al. "SAT-176 Epidemiology of Adrenal Tumors: A Population Based Study of 1287 Patients." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.189.

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Abstract Background: Adrenal tumors are reported in 5% of adults, with malignancy rates in 1–12%, and rates of overt hormonal excess in 1–15 %. However, most estimates originate from convenience samples. Our objective was to determine the incidence, prevalence and clinical presentation of adrenal tumors in a population-based setting. Methods: We used a centralized epidemiologic database to identify patients diagnosed with adrenal tumors in a local community 1995 to 2017. The database is a unique medical records linkage system that allows access to hospital and community medical records for loc

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Araujo-Espinoza, Guillermo, Al-Hassan Dajani, Mathangi Sridharan, Brendan Shi, Kristofer Jones, and Thomas Kremen. "Poster 101: Ultrasound-Guided Barbotage Decreases the Rate of Surgery for Rotator Cuff Calcific Tendinitis. A Single-Institution Ten-Year Retrospective Analysis." Orthopaedic Journal of Sports Medicine 12, no. 7_suppl2 (2024). http://dx.doi.org/10.1177/2325967124s00071.

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Objectives: Rotator cuff calcific tendinopathy (RCCT) is a common condition characterized by the presence of calcific deposits in the rotator cuff tendons or the subacromial space. Its prevalence in individuals experiencing shoulder pain ranges from 7.3% to 42%. This condition mainly affects people aged between 30 and 60 and is more common among women. Subacromial corticosteroid injections (SAI) are considered a standard treatment for RCCT. Although ultrasound-guided barbotage (UGB) is thought to improve clinical and radiographic outcomes in treating RCCT, its impact on the rate of subsequent

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Minh, Phan Hong, Vu Khanh Linh, Nguyen Thanh Hai, and Bui Thanh Tung. "A Comprehensive Review of Vaccines against Covid-19." VNU Journal of Science: Medical and Pharmaceutical Sciences 37, no. 3 (2021). http://dx.doi.org/10.25073/2588-1132/vnumps.4365.

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The globe is engulfed by one of the most extensive public health crises as COVID-19 has become a leading cause of death worldwide. COVID-19 was first detected in Wuhan, China, in December 2019, causing the severe acute respiratory syndrome. This review discusses issues related to Covid-19 vaccines, such as vaccine development targets, vaccine types, efficacy, limitations and development prospects. Keywords: Covid-19, SARS-CoV-2, vaccine, spike protein. References [1] C. Wang, P. W. Horby, F. G. Hayden, G. F. Gao, A Novel Coronavirus Outbreak of Global Health Concern, The Lanc

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sprotocols. "Assay for quantitative determination of CYP1A1 enzyme activity using 7-Ethoxyresorufin as standard substrate (EROD assay)." December 31, 2014. https://doi.org/10.5281/zenodo.13665.

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Authors: Afshin Mohammadi-Bardbori ### Abstract The activity of the enzyme 7-ethoxy-resorufin-O-deethylase (EROD) has been extensively employed in biomonitoring studies of persistent organic pollutants (POPs) for more than a decade. Although the procedure is simple, convenient, sensitive and accurate. The cytochrome P450 monooxygenase 1A (CYP1A) is induced by several planar toxic compounds and endogenous chemicals, and the induction of this protein is often measured in terms of EROD activity. This protocol describes how to use EROD activity in the prediction of toxicity of chemicals in several

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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Kojo, Kosuke, Tomoko Oguri, Takazo Tanaka, et al. "Seminal plasma metallomics: a new horizon for diagnosing and managing male infertility." Revista Internacional de Andrología 23, Published Ahead of Print (2025). https://doi.org/10.22514/j.androl.2025.013.

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The authors, Kosuke Kojo and Tomoko Oguri, contributed equally. This HTML edition is publicly accessible at the following URL:https://academic298uro.github.io/open-archive/2025/seminal-plasma-metallomics-new-horizon/ Abstract Seminal plasma contains a wide range of biomolecules—including inorganic elements—that may significantly influence male reproductive function. Historically, semen analysis has focused on sperm count and motility, while overlooking the diagnostic potential of this acellular fraction. This narrative review synthesizes historical perspectives on seminal plasma me

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