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Journal articles on the topic '791.436 58'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Lian, Tian-Yu, Dan Lu, Xin-Xin Yan, et al. "Association between congenital thrombophilia and outcomes in pulmonary embolism patients." Blood Advances 4, no. 23 (2020): 5958–65. http://dx.doi.org/10.1182/bloodadvances.2020002955.

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Abstract The prevalence and distribution of congenital thrombophilia is still unclear in patients with pulmonary embolism (PE). We aimed to determine the prevalence and clinical characteristics of congenital thrombophilia in PE patients and their subsequent outcomes. A prospective observational study was conducted from May 2013 to June 2018. A total of 436 consecutive patients with PE were enrolled. All patients were tested for protein C, protein S, antithrombin III (ATIII), factor V Leiden, and prothrombin G20210A mutations. The median follow-up duration was ∼800 days (range, 11-1872 days). C

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Huang, Xiao-Jun, Hong-Hu Zhu, Ying-Jun Chang, et al. "The superiority of haploidentical related stem cell transplantation over chemotherapy alone as postremission treatment for patients with intermediate- or high-risk acute myeloid leukemia in first complete remission." Blood 119, no. 23 (2012): 5584–90. http://dx.doi.org/10.1182/blood-2011-11-389809.

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Abstract We report the results of a prospective, patient self-selected study evaluating whether haploidentical related donor stem cell transplantation (HRD-HSCT) is superior to chemotherapy alone as postremission treatment for patients with intermediate- or high-risk acute myeloid leukemia (AML) in first complete remission (CR1). Among totally 419 newly diagnosed AML patients, 132 patients with intermediate- and high-risk cytogenetics achieved CR1 and received chemotherapy alone (n = 74) or HSCT (n = 58) as postremission treatment. The cumulative incidence of relapse at 4 years was 37.5% ± 4.5

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Vorob’eva, O. V., and V. V. Fateeva. "Depressive disorder and quality of life in patients with cerebral microangiopathy." Sechenov Medical Journal 11, no. 1 (2020): 49–58. http://dx.doi.org/10.47093/2218-7332.2020.11.1.49-58.

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The association between depressive disorder and quality of life of middle-aged patients with cerebral microangiopathy has not been fully investigated.Aim. Study the association between the depression level and quality of life (QOL) in patients with cerebral microangiopathy.Materials and methods. In outpatients 45–59 years old (n = 262, 42% men, 58% women) with cerebral microangiopathy and depression, the level of anxiety was assessed using the HADS-A scale, QOL — using the SF-36 questionnaire. According to the severity of depression (HADS-D subscale), the following were distinguished: group 1

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Lerda, Robert, Chantal Cardelli, and Jean-Pierre Coudereau. "Backstroke Organization in Physical Education Students as a Function of Skill and Sex." Perceptual and Motor Skills 100, no. 3 (2005): 779–90. http://dx.doi.org/10.2466/pms.100.3.779-790.

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This study assessed how stroking in backstroke varies with performance status and sex. A total of 36 subjects were separated into two groups of 18 by sex and further divided into two subgroups of nine, faster and slower, based on velocity in the 100-m event. Stroking parameters and coordination indexes were measured at this 100-m pace. Index 1 characterizes the continuity between propulsive phases of each arm and Index 2, the simultaneity between the beginning of the pull of one arm and of the recovery of the other arm. It is shown that the entry-catch and clearing vary ( p< .05) between me

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Duesberg, Christoph Benedikt, Christina Valtin, Jan Fuge, et al. "A Before-and-After Study of Evidence-Based Recommendations for On-Call Bronchoscopy." Respiration 100, no. 7 (2021): 600–610. http://dx.doi.org/10.1159/000515134.

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<b><i>Background:</i></b> Bronchoscopy is widely used and regarded as standard of care in most intensive care units (ICUs). Data concerning recommendations for on-call bronchoscopy are lacking. <b><i>Objectives:</i></b> Evaluation of recommendations, complications, and outcome of on-call bronchoscopies. <b><i>Method:</i></b> A retrospective single-centre analysis was conducted in a large university hospital. All on-call bronchoscopies performed outside normal working hours in the year before (period 1) and after (period 2)

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Christ, F., A. Bauer, D. Brügger, M. Niklas, I. B. Gartside, and J. Gamble. "Description and validation of a novel liquid metal-free device for venous congestion plethysmography." Journal of Applied Physiology 89, no. 4 (2000): 1577–83. http://dx.doi.org/10.1152/jappl.2000.89.4.1577.

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We present a newly developed electromechanical sensor with automated calibration for strain-gauge plethysmography (filtrass) and compare it to a conventional mercury-in-Silastic strain-gauge plethysmograph (MSG). Fluid filtration capacity ( K f) and isovolumetric venous pressure (Piv) of the limb were assessed noninvasively with both devices in 29 healthy volunteers. We found significantly higher Kf and Piv values with MSG [4.6 ± 2.0 × 10−3ml · min−1 · mmHg−1 · 100 ml tissue−1 ( K f units; K fU) and 21.2 ± 8.1 mmHg for Pvi], than with filtrass, giving values of 3.1 ± 0.8 K fU and 15.1 ± 7.1 mm

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Kim, Dong-Hyun, and Soo-Young Ye. "Classification of Chronic Kidney Disease in Sonography Using the GLCM and Artificial Neural Network." Diagnostics 11, no. 5 (2021): 864. http://dx.doi.org/10.3390/diagnostics11050864.

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Chronic kidney disease (CKD) can be treated if it is detected early, but as the disease progresses, recovery becomes impossible. Eventually, renal replacement therapy such as transplantation or dialysis is necessary. Ultrasound is a test method with which to diagnose kidney cancer, inflammatory disease, nodular disease, chronic kidney disease, etc. It is used to determine the degree of inflammation using information such as the kidney size and internal echo characteristics. The degree of the progression of chronic kidney disease in the current clinical trial is based on the value of the glomer

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Rha, Brian, Angela P. Campbell, Darius McDaniel, et al. "751. Acute Respiratory Illness Hospitalizations Among Young Children: Multi-Center Viral Surveillance Network, United States, 2015–2016." Open Forum Infectious Diseases 5, suppl_1 (2018): S270. http://dx.doi.org/10.1093/ofid/ofy210.758.

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Abstract Background Viral infections are a significant cause of severe acute respiratory illnesses (ARI) in young children. Understanding the current epidemiology of these viruses is important for informing treatment and prevention measures. We describe the New Vaccine Surveillance Network (NVSN) and report preliminary results from 2015 to 2016. Methods Prospective active surveillance for hospitalized ARI was conducted from November 1, 2015 to June 30, 2016 among children &lt;5 years of age at seven pediatric hospital sites (figure) using a broad case definition based on admission diagnose

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Arora, Sukeshi Patel, Norma S. Ketchum, Jonathan Gelfond, Joel Michalek, and Devalingam Mahalingam. "Comparative efficacy and safety of sorafenib in elderly versus non-elderly patients with advanced hepatocellular carcinoma (HCC) with varying liver dysfunction." Journal of Clinical Oncology 36, no. 4_suppl (2018): 430. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.430.

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430 Background: Sorafenib is the only FDA-approved systemic therapy for advanced HCC. The incidence of HCC increases with age, peaking above 70 years; however, we have limited efficacy and safety data in the elderly. Given the prevalence of HCC in South Texas, we assessed the efficacy and safety of sorafenib in the elderly. Methods: Retrospective analysis of HCC patients (pts) receiving sorafenib from 2008-2013. PFS and OS were estimated from Kaplan-Meier curves and groups were statistically compared with the log rank test. The magnitude of association between dichotomous factors and survival

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Maslennikova, Olga, and Viktoriya Erofeeva. "Assessment of soil biocontamination with toxocara eggs in urbanized ecosystems." E3S Web of Conferences 265 (2021): 03010. http://dx.doi.org/10.1051/e3sconf/202126503010.

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Toxocariasis in the Russian Federation is the most dangerous of the common helminthiases that can affect dogs or cats. Toxocariasis is a zoonotic geohelminthiasis, which is naturally transmitted from vertebrates to humans and poses a threat to people as a source of infection in megacities. In order to study the prevalence of toxocars among domestic and stray dogs living in the urbanized ecosystems of the Kirov region, the study of dog excrement by the flotation method has been carried out for 3 years. The results of the research show that, on average, in the village of Zagarye of the Yuryansk

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O’Neil, Carol E., Michael Zanovec, Theresa A. Nicklas, and Susan S. Cho. "Presweetened and Nonpresweetened Ready-to-Eat Cereals at Breakfast Are Associated With Improved Nutrient Intake but Not With Increased Body Weight of Children and Adolescents." American Journal of Lifestyle Medicine 6, no. 1 (2011): 63–74. http://dx.doi.org/10.1177/1559827610395476.

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This study compared nutrient intake and body weight measures in children 4 to 8 (n = 1480) and 9 to 13 (n = 1790), and adolescents 14 to 18 years of age (n = 1826) participating in 1999-2002 NHANES and consuming a presweetened ready-to-eat cereal (PSRTEC), a non-PSRTEC (NPSRTEC), or other breakfast (OB). Sample weights were applied, and logistic regression identified differences among breakfast consumption groups controlling for appropriate covariates. Breakfast type varied by the above-mentioned age groups: 34% (n = 507), 33% (n = 593), and 23% (n = 416) consumed PSRTEC, respectively; 12% (n

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Chakhalian, M., E. Gaidar, T. Nikitina, et al. "AB0748 ARE ANY DIFFERENCES BETWEEN JIA - ASSOCIATED UVEITIS, DEVELOPED BEFORE AND AFTER JOINT MANIFESTATION." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1402.2–1402. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3704.

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Background:Uveitis is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA). Usually uveitis developed during first two years after arthritis occurred [1]. In the previous studies was shown the shorter time interval between arthritis and uveitis the severe uveitis course was observed [2]. Information about course of uveitis developed before arthritis is scarce.Objectives:We aimed to evaluate the clinical features and therapy of JIA-associated uveitis, which developed before and after joint manifestation.Methods:In the retrospective study 191 pediatric autoimmune

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Vogl, T. J., N. Naguib, S. Zangos, K. Eichler, and T. Gruber. "Repeated transarterial chemoperfusion and -embolization (TACE) in primary hepatic cholangiocarcinoma (CCC): Local tumor control and survival rate." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15595-e15595. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15595.

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e15595 Background: To evaluate local tumor control and survival data in the palliative and symptomatic treatment of hepatic cholangiocarcinoma (CCC) using repeated transarterial chemoperfusion and -embolization (TACE) with two different chemotherapy protocols. Methods: 41 patients with primary cholangiocarcinoma (CCC) were repeatedly treated with transarterial chemoembolization (TACE) in 4-week intervals. In total, 291 TACE sessions were performed with a mean of 7.1 sessions per patient (mean age: 57.1 years; range, 37–80 years). 22 patients had multiple tumors, 6 showed 1 lesion, 5 had 2 lesi

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Manfron, Ana Paula Tulio, Alessandra S. Ditzel, Flávia N. G. K. Fontão, and Luciana R. Azevedo Alanis. "Evaluation of Retromolar Canals using Cone Beam Computer Tomography/ Avaliação do canal retromolar por meio de tomografia computadorizada de feixe cônico." Brazilian Journal of Health Review 4, no. 4 (2021): 15952–61. http://dx.doi.org/10.34119/bjhrv4n4-123.

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The aim of this study was to evaluate the prevalence, location and clinical implications related to the presence of the retromolar canal (RMC) on cone beam computed tomography(CBCT). CBCT images of patients from Latin America Institute for Dental Research and Education - Curitiba,Pr,Brazil, was performed from June/2008 to February/2013. The interpretation was performed by a calibrated examiner, according to the criterias: presence, location and classification of the RMC variation, as well as, measurements of horizontal distances of the RMC in relation to the buccal bone cortical and diameter o

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Rai, Ansaar T., SoHyun Boo, Chelsea Buseman, et al. "Intravenous thrombolysis before endovascular therapy for large vessel strokes can lead to significantly higher hospital costs without improving outcomes." Journal of NeuroInterventional Surgery 10, no. 1 (2017): 17–21. http://dx.doi.org/10.1136/neurintsurg-2016-012830.

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BackgroundLimited efficacy of IV recombinant tissue plasminogen activator (rt-PA) for large vessel occlusions (LVO) raises doubts about its utility prior to endovascular therapy.PurposeTo compare outcomes and hospital costs for anterior circulation LVOs (middle cerebral artery, internal carotid artery terminus (ICA-T)) treated with either primary endovascular therapy alone (EV-Only) or bridging therapy (IV+EV)).MethodsA single-center retrospective analysis was performed. Clinical and demographic data were collected prospectively and relevant cost data were obtained for each patient in the stud

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Mitchell, Brendon C., Matthew Y. Siow, Andrew T. Pennock, Eric W. Edmonds, Tracey P. Bastrom, and Henry G. Chambers. "Intra-articular Morphine and Ropivacaine Injection Provides Efficacious Analgesia As Compared With Femoral Nerve Block in the First 24 Hours After ACL Reconstruction: Results From a Bone–Patellar Tendon–Bone Graft in an Adolescent Population." Orthopaedic Journal of Sports Medicine 9, no. 3 (2021): 232596712098590. http://dx.doi.org/10.1177/2325967120985902.

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Background: Opioid consumption and patient satisfaction are influenced by a surgeon’s pain-management protocol as well as the use of adjunctive pain mediators. Two commonly utilized adjunctive pain modifiers for anterior cruciate ligament (ACL) reconstruction are femoral nerve blockade and intra-articular injection; however, debate remains regarding the more efficacious methodology. Hypothesis: We hypothesized that intra-articular injection with ropivacaine and morphine would be found to be as efficacious as a femoral nerve block for postoperative pain management in the first 24 hours after bo

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Károly Máriás and Péter Pepó. "Examination of the population density and sowing date of different maize genotypes in the Hajdúság region." Acta Agraria Debreceniensis, no. 48 (July 31, 2012): 111–15. http://dx.doi.org/10.34101/actaagrar/48/2464.

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The experiment was carried out 6 km from Debrecen, next to the main road 47 on a homogeneous field on brown forest soil. Five corn hybrids were tested in the trial (DKC 4795, DKC 4995, KWS Kornelius, NK Cobalt, PR37 N01) at three different sowing times (early – 5th April, average – 21st April, late – 10th May). At each sowing time, three different plant densities were applied (modest – 58 500 plants ha-1, average –70 200 plants ha-1, high – 82 300 plants ha-1). The agrotechnics appliedin the experiment satisfied the requirements of modern corn cultivation. In the study, the best yield re

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dos Santos, P. A., C. B. V. Rabello, N. K. Sakomura, et al. "Modelling of the nitrogen deposition and dietary lysine requirements of Redbro broilers." Animal Production Science 54, no. 12 (2014): 1946. http://dx.doi.org/10.1071/an14543.

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The aim of this study was to determine the coefficients of the Goettingen model for Redbro birds and estimate the digestible lysine requirements. To determine the model parameters, three nitrogen balance trials were performed in Periods I (14–28 days), II (42–56 days) and III (70–84 days), using 42 birds per trial. The birds were individually housed and subjected to six diets with increasing levels of nitrogen, with lysine as the limiting amino acid (deficient by 20% in relation to other amino acids). Dietary nitrogen concentrations were 8, 16, 24, 32, 40 and 48 g/kg. A control diet was added

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Grilo, C., and D. Becker. "Binge-eating disorder and major depressive disorder co-morbidity: Sequence and clinical significance." European Psychiatry 33, S1 (2016): S163. http://dx.doi.org/10.1016/j.eurpsy.2016.01.322.

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IntroductionBinge-eating disorder (BED) is associated with obesity and with elevated rates of co-occurring major depressive disorder (MDD) but the significance of the diagnostic comorbidity is ambiguous—as is the significance of the onset sequence for MDD and BED.Objective and aimsWe compared eating-disorder psychopathology and psychiatric comorbidity in three subgroups of BED patients: those in whom onset of BED preceded onset of MDD, those with onset of MDD prior to onset of BED, and those without MDD or any psychiatric comorbidity.MethodsA consecutive series of 731 treatment-seeking patient

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Klein, A., T. Hospach, F. Weller-Heinemann, et al. "SAT0490 MATCHED CONTROLLED SURVEILLANCE OF TOCILIZUMAB TREATMENT FOR POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS–AN INTERIM ANALYSIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1201.2–1202. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4363.

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Background:Tocilizumab (TOC) is approved for treatment of polyarticular juvenile idiopathic arthritis (pJIA). Data out of clinical practice are limited.Objectives:Long-term surveillance of patients initiating TOC treatment compared to a cohort of patients initiating a comparator biologic using the BIKER-registry.Methods:Baseline parameters, efficacy and safety parameters were compared. Efficacy outcomes were JADAS10 and joint counts. Functional status was determined with the Childhood Health Assessment Questionnaire disability-index (CHAQ-DI). Safety was assessed by adverse events (AE) reports

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Gourin, Marie-Pierre, Franck Trimoreau, Nathalie Gachard, et al. "Is It Relevant to Determine Routinely Levels of Circulating NK and NK Like Cells in Myelodyplastic Syndroms?." Blood 114, no. 22 (2009): 2786. http://dx.doi.org/10.1182/blood.v114.22.2786.2786.

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Abstract Abstract 2786 Poster Board II-762 Purpose: Myelodysplastic syndromes (MDS) are characterized by an ineffective haematopoiesis due to different pathways: Intrinsic factors as cytogenetic and molecular abnormalities and extrinsic factors as disturbance in cellular immunity. An excess or abnormal natural killer (NK) cells cytolytic function have been previously described in MDS. A sub-group of MDS characterized by bone marrow hypoplasia, an excess of NK, HLA-DR15 and trisomy 8 may respond to an immune-suppressive therapy by antithymocyte globuline (ATG) or Cyclosporin. Recent advances in

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Sycheva, Elena G., Niso M. Nazarova, Olga V. Burmenskaya, Vera N. Prilepskaya, and Dmitry Yu Trofimov. "The occurrence of human papillomavirus types in the formation of neoplastic transformation of the epithelium of the cervix in “lesser abnormalies”." Gynecology 22, no. 1 (2020): 19–22. http://dx.doi.org/10.26442/20795696.2020.1.200015.

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Aim. To assess the frequency of human papillomavirus (HPV) occurrence according to the IARC classification in patients with lesser abnormalie of cervical epithelial lesions and analyze their role in the formation of SIL. Materials and methods. The study included 129 HPV-positive women aged 1845 years (average age 34 to 11 years) with cytological conclusion NILM, ASCUS or LSIL. Patients are divided into 3 groups depending on the results of the cytological smear: 1 group (NILM/HPV) 66 (51.2%), 2 group (ASCUS/HPV) 28 (21.7%), 3 group (LSIL/HPV) 35 (27.1%). During dynamic observation for 24

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Endrikat, Jan, Carsten Schwenke, Kai Vogtlaender, Susan Dohannish, and Josy Breuer. "Safety profile of gadoxetate disodium in elderly patients (≥65 years)." Acta Radiologica 59, no. 1 (2017): 81–88. http://dx.doi.org/10.1177/0284185117700673.

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Background Safety data on routine clinical use of gadoxetate disodium in elderly patients is not reported yet. Purpose To assess the safety of liver specific gadoxetate disodium in contrast enhanced magnetic resonance imaging in elderly patients (≥65 years) in comparison to adults (18–64 years). Material and Methods Safety data on gadoxetate disodium were analyzed from 12 clinical phase II–III studies and from our pharmacovigilance database. A comparison between elderly (≥65 years) versus adults (18–64 years) was performed with respect to the frequency of drug-related adverse events (AEs) in c

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Mitchell, Brendon C., Matthew Y. Siow, Andrew T. Pennock, Eric W. Edmonds, Tracey P. Bastrom, and Henry G. Chambers. "INTRA-ARTICULAR MORPHINE AND ROPIVACAINE INJECTION PROVIDES EFFICACIOUS ANALGESIA COMPARED TO FEMORAL NERVE BLOCK IN THE FIRST 24 HOURS POST-OPERATIVELY AFTER ACL RECONSTRUCTION WITH BTB IN AN ADOLESCENT COHORT." Orthopaedic Journal of Sports Medicine 9, no. 7_suppl3 (2021): 2325967121S0002. http://dx.doi.org/10.1177/2325967121s00023.

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Background: Opioid consumption and patient satisfaction are influenced by a surgeon’s pain management protocol and the use of adjunctive pain mediators. Two commonly utilized adjunctive pain modifiers for anterior cruciate ligament (ACL) reconstruction include femoral nerve blockade and intra-articular injection; however, debate remains as to the most efficacious methodology. Hypothesis/Purpose: We hypothesize that intra-articular injection with ropivacaine and morphine is as efficacious as a femoral nerve block injection of ropivacaine, dexamethasone, and dexmedetomidine for post-operative pa

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Bergeron, Mathieu, Robert J. Fleck, Stephanie R. C. Zacharias, Meredith E. Tabangin, and Alessandro de Alarcon. "The Value of Dynamic Voice CT Scan for Complex Airway Patients Undergoing Voice Surgery." Annals of Otology, Rhinology & Laryngology 128, no. 10 (2019): 885–93. http://dx.doi.org/10.1177/0003489419846138.

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Introduction:Dynamic voice computerized tomography (DVCT) is a novel technique that provides additional information to characterize laryngeal function for patients with complex airway history that may alter surgical decisions. The goal of this study was to evaluate the impact of DVCT on decision making for reconstructive voice surgery for a cohort of post-airway reconstruction dysphonia patients.Methods:Retrospective chart review at a pediatric tertiary care center for patients with history of complex airway surgery and subsequent reconstructive voice surgery for dysphonia between 2010 and 201

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Zhang, W., D. Yang, M. Capanu, et al. "Pharmacogenomic analysis of a randomized phase II trial (BOND 2) of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4128. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4128.

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4128 Background: Phase II CBI VS CB trial has shown that bevacizumab added the efficacy of cetuximab and cetuximab/irinotecan in irinotecan-refractory bevacizumab-naïve CRC patients. We tested the germline polymorphisms involved in angiogenesis pathway(VEGF, IL-8, TGF-β), EGFR pathway (EGFR, COX-2, CyclinD1,E-cadherin,FCGR2A,3A), DNA repair pathway(ERCC1, XRCC1, XPD) and drug metabolism pathway (GSTP1, UGT1A1) to evaluate their association with clinical outcome. Here we expand our gene polymorphisms data involving EGFR pathway (EGF, FCGR2B, Survivin, ADAMS10/17), Angiogenesis pathway (Neuropil

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Bannister, P., and A. Memon. "Trends in Incidence of Primary Liver Cancer in the Elderly (Aged 65+ Years) in England, 1971-2010." Journal of Global Oncology 4, Supplement 2 (2018): 12s. http://dx.doi.org/10.1200/jgo.18.69000.

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Background: About 45% of the cases of liver cancer in England are diagnosed in the elderly. Since the 1990s, there has been a substantial increase in the incidence of liver cancer, and it has been projected that the incidence of rates will continue to increase to 15/100,000 by 2035. Aim: To determine the trends of incidence of liver cancer in the elderly in England during the period 1971-2010. Methods: Population-based national cancer registration data (obtained from the Office for National Statistics) were analyzed to determine the incidence of liver cancer (ICD-9 code: 155, ICD-10 code: C22)

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Rivellese, F., E. Pontarini, L. Fossati-Jimack, et al. "OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 7.2–7. http://dx.doi.org/10.1136/annrheumdis-2021-eular.438.

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Background:The study of synovial tissue in patients with Rheumatoid Arthritis (RA) has led to the identification of synovial patterns of immune cell infiltration and specific cellular subsets associated that have been disease activity and clinical outcomes(1–3). However, the relationship of circulating and synovial immune cell sub-sets with histopathological features and clinical outcomes remains to be defined.Objectives:To assess the relationship of peripheral blood and synovial immune cells with RA histopathology and clinical outcomes, by performing flow and digital cytometry in matched peri

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Christiansen, Christian F., Karynsa Cetin, Merete Lund Mægbæk, et al. "A Nordic Population-Based Cohort Study of Risk of Arterial Thrombotic and Venous Thromboembolic Events in Patients with Primary Chronic Immune Thrombocytopenia (cITP)." Blood 124, no. 21 (2014): 4845. http://dx.doi.org/10.1182/blood.v124.21.4845.4845.

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Abstract Background: ITP is a rare autoimmune disorder characterized by low platelet counts, resulting in an increased risk for bleeding. Paradoxically, patients with cITP may also have an increased incidence of thrombotic or thromboembolic events, but population-based data on this are limited. We estimated the incidence of these events in a prospective cohort study of incident cITP patients in three Nordic countries. Methods: Based on National Health Registry Systems (NHRSs) and medical records in Denmark, Norway, and Sweden, the study cohort included all adults diagnosed with cITP from Janua

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Webb, Penelope M., Anna deFazio, Andreas Obermair, et al. "The Ovarian cancer Prognosis And Lifestyle (OPAL) study." Journal of Clinical Oncology 36, no. 7_suppl (2018): 88. http://dx.doi.org/10.1200/jco.2018.36.7_suppl.88.

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88 Background: Five-year survival after a diagnosis of ovarian cancer (OC) is < 45% and women often ask what they can do, beyond following the recommended treatment, to improve their chance of survival. The OPAL Study addresses the question of whether lifestyle choices during or after treatment could positively impact quality of life (QoL) and, ultimately, survival. Methods: OPAL is a prospective study of Australian women newly diagnosed with primary OC from 2012-15 who agreed to complete questionnaires at baseline, 3, 6, 9, 12, 24, 36 & 48 months after diagnosis. Baseline data include

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Kuchenbauer, Florian, Donald W. Bunjes, Wolfgang Herr, et al. "Impact of Donor Type on Outcome after Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia Patients: Analysis of the German-Austrian Acute Myeloid Leukemia Study Group (AMLSG)." Blood 124, no. 21 (2014): 1254. http://dx.doi.org/10.1182/blood.v124.21.1254.1254.

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Abstract Background:Despite recent advances in identifying novel molecular targets in AML patients, intensive chemotherapy followed by allogeneic hematopoietic stem cell transplantation (HSCT) still remains a cornerstone of AML therapy. However, outcome of HSCT depends on the availability of a donor and the donor type. Prior studies comparing HSCT from HLA-matched related donors (MRD) with matched unrelated donors (MUD), demonstrated conflicting results with regards to outcome. These conflicting results might be attributed to the genetic heterogeneity of AML. Aims:To analyze outcome with respe

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Norasetthada, Lalita, Weerasak Nawarawong, Arnuparp Lekhakula, et al. "Consolidation Radiotherapy Improved Survival in Limited Stage Diffuse Large B-Cell Lymphoma (DLBCL): A Nationwide Multi-Institutional Registry of 816 Cases in Thailand." Blood 126, no. 23 (2015): 2712. http://dx.doi.org/10.1182/blood.v126.23.2712.2712.

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Abstract Introduction The additional benefit of consolidation radiotherapy (RT) following chemotherapy in limited stage DLBCL remains controversial. Previous 5 randomized trials, 4 trials before rituximab era (SWOG 8736, ECOG 1484, GELA 93-1 and 93-4 studies) and 1 trial with R-CHOP combination (Lysa/Goelams 02-03), could not demonstrate a remarkable benefit of RT. The purpose of this study is to explore the benefit of combined modality treatment including the combination of RT and rituximab (R)-based chemotherapy in limited stage DLBCL. Methods From the 4,371 patients in a multi-institutional

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Sokol, Ethan, Smruthy Sivakumar, Dexter Jin, et al. "Patient-matched tissue and liquid biopsies identify shared and acquired genomic alterations in breast cancer." Journal of Clinical Oncology 38, no. 15_suppl (2020): 1050. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.1050.

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1050 Background: Liquid biopsy-based comprehensive genomic profiling (CGP) is a minimally invasive approach to potentially identify truncal driver alterations and mechanisms of acquired resistance. However, there are limited data comparing solid tissue and plasma biopsies from the same patient in breast cancer. Methods: CGP was performed on matched tumor tissue and plasma samples from 444 patients with breast cancer (Foundation Medicine, Inc.) to identify short variant mutations and rearrangements in at least 62 genes. ER/PR/HER2 status was abstracted for a subset of patients (n = 273). Patien

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Martin, RobRoy L., John J. Christoforetti, Ryan McGovern, et al. "The Impact of Depression on Patient Outcomes in Hip Arthroscopic Surgery." Orthopaedic Journal of Sports Medicine 6, no. 11 (2018): 232596711880649. http://dx.doi.org/10.1177/2325967118806490.

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Background: Mental health impairments have been shown to negatively affect preoperative self-reported function in patients with various musculoskeletal disorders, including those with femoroacetabular impingement. Hypothesis: Those with symptoms of depression will have lower self-reported function, more pain, and less satisfaction on initial assessment and at 2-year follow-up than those without symptoms of depression. Study Design: Cohort study; Level of evidence, 3. Methods: Patients who were enrolled in a multicenter hip arthroscopic surgery registry and had 2-year outcome data available wer

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VAN BERKEL, Theo J. C., Agnes VAN VELZEN, Johan K. KRUIJT, Hiroshi SUZUKI, and Tatsushiko KODAMA. "Uptake and catabolism of modified LDL in scavenger-receptor class A type I/II knock-out mice." Biochemical Journal 331, no. 1 (1998): 29–35. http://dx.doi.org/10.1042/bj3310029.

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The liver is the major organ responsible for the uptake of modified low-density lipoprotein (LDL) from the blood circulation, with endothelial and Kupffer cells as major cellular uptake sites. Scavenger-receptors, which include various classes, are held responsible for this uptake. Mice deficient in scavenger-receptor class A types I and II were created and the fate of acetylated LDL (Ac-LDL) in vivo and its interaction with liver endothelial, Kupffer and peritoneal macrophages was characterized. Surprisingly, the decay in vivo (t½ < 2 min), tissue distribution and liver uptake (at 5 min it

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Hanzel, Adrienn. "Újszerű megközelítés: pontozáson alapuló, testmozgást ösztönző módszer – cikkismertetés." Egészségfejlesztés 59, no. 3 (2018): 57–58. http://dx.doi.org/10.24365/ef.v59i3.302.

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Bevezetés: A közelmúltban végzett vizsgálatok arra hívják fel a figyelmet, hogy a középkorú nők két alapvető dolog miatt nem végeznek fizikai aktivitást, egyrészt az idő hiánya miatt, másrészt a motiváció hiánya miatt. Ezért a szerzők úgy gondolták, hogy ki kellene dolgozni egy olyan technikát, amely beleilleszthető a mindennapi életbe. Kutatás célja: Megvizsgálni, hogy az új "pontozás alapú" fizikai aktivitás (PBPA) mérési módszernek milyen hatásai vannak a testösszetételre az inaktív nők körében, akik túlsúlyosak vagy elhízottak, szemben a strukturált testmozgást végzőkkel. Módszerek: 76 túl

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Måwe, Leif, Lena Måwe Thorén, and Gunnvald Kvarstein. "Responses after spinal interventions in a clinical pain practice – a pragmatic observational study." Scandinavian Journal of Pain 20, no. 3 (2020): 469–82. http://dx.doi.org/10.1515/sjpain-2019-0126.

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AbstractIntroductionThere is limited evidence for effect of interventional treatment, and pragmatic studies are needed to assess these interventions within a clinical setting. The aim of this study was to describe patients referred to an interventional pain clinic and investigate responses after spinal intervention in general and for radiofrequency ablation (RFA) and transforaminal epidural corticosteroid administration (TECA), specifically.MethodsThis is a prospective, non-controlled study of patients with chronic spinal pain. The procedures were performed in accordance with the Spine Interve

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Hardy, Nancy M., Frances Hakim, Seth Steinberg, et al. "Ex-Vivo Reduction of Allograft T Cell Dose Does Not Prevent Acute Graft-vs-Host Disease after Reduced-Intensity Hematopoietic Stem Cell Transplantation." Blood 108, no. 11 (2006): 2871. http://dx.doi.org/10.1182/blood.v108.11.2871.2871.

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Abstract Allograft T cell depletion (TCD) reduces acute graft-vs. host disease (aGVHD) after myeloablative hematopoietic stem cell transplantation (HSCT). Lower incidences of aGVHD reported after reduced-intensity stem cell transplantation (RIST) may reflect delayed donor T cell engraftment. We compared the incidence of aGVHD following RIST with TCD (19 patients (pts) vs. T cell replete (TCR) allografts (20 pts)(Table). There was no difference in the incidence aGVHD, occurring in 71% of TCD recipients (median onset Day 47) and 70% of TCR recipients (median onset Day 25). After TCD, 100% of tho

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van Seeters, Tom, Geert Jan Biessels, L. Jaap Kappelle, et al. "The Prognostic Value of CT Angiography and CT Perfusion in Acute Ischemic Stroke." Cerebrovascular Diseases 40, no. 5-6 (2015): 258–69. http://dx.doi.org/10.1159/000441088.

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Background: CT angiography (CTA) and CT perfusion (CTP) are important diagnostic tools in acute ischemic stroke. We investigated the prognostic value of CTA and CTP for clinical outcome and determined whether they have additional prognostic value over patient characteristics and non-contrast CT (NCCT). Methods: We included 1,374 patients with suspected acute ischemic stroke in the prospective multicenter Dutch acute stroke study. Sixty percent of the cohort was used for deriving the predictors and the remaining 40% for validating them. We calculated the predictive values of CTA and CTP predict

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Gonzalez, R. A., E. J. Gómez, L. Pereyra, et al. "P232 In suspected small bowel Crohn’s disease: Clinical impact of using capsule endoscopy to make decisions." Journal of Crohn's and Colitis 14, Supplement_1 (2020): S258—S259. http://dx.doi.org/10.1093/ecco-jcc/jjz203.361.

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Abstract Background Capsule endoscopy (CE) can detect small bowel (SB) lesions compatible of Crohn’s disease (CD) in patients with suggestive symptoms but with inconclusive results for the diagnostic workup. However, the clinical impact of CE in helping physicians to make decisions about patients with suspected CD is not currently well established. The aim of the study was to investigate the clinical impact of CE to confirm diagnosis of CD and also to evaluate whether the results of CE modify therapeutic decisions. Methods We conducted a single-centre retrospective cohort study. All consecutiv

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Miller, Scott T., Winfred C. Wang, Rathi V. Iyer, et al. "Urine Concentrating Ability in Infants with Sickle Cell Anemia: Baseline Data from the BABY HUG Trial." Blood 112, no. 11 (2008): 1413. http://dx.doi.org/10.1182/blood.v112.11.1413.1413.

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Abstract A urine concentrating defect is quite common in sickle cell anemia (SCA), has its onset in early childhood, and may be reversible (with transfusion) until age 10 years. BABY HUG is an NHLBI-NICHD sponsored double-blind, placebo-controlled Phase III Clinical Trial (NCT00006400) designed to assess efficacy of hydroxyurea in preventing organ damage in young children with SCA (Hb SS or SβO thalassemia); primary endpoints are spleen function and glomerular filtration rate (GFR). Two hundred thirty-three infants, recruited without regard to disease severity, underwent eligibility screening.

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Trebouet, Adrien, Tony Marchand, Richard Lemal, et al. "Lymphoma Occurring Over the Age of 90: Clinical Presentation and Outcome." Blood 120, no. 21 (2012): 1582. http://dx.doi.org/10.1182/blood.v120.21.1582.1582.

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Abstract Abstract 1582 Background Lymphoma occurring in very elderly patients (i.e. >90 years of age) is not uncommon and its incidence is expected to increase due to prolongation of life expectancy. Its management raises therapeutic as well as ethical considerations. However, no reports are currently available in this population of patients rendering their management particularly challenging. The purpose of our study is to describe the clinical presentation, management and outcome of patients diagnosed with lymphoma at the age of 90 or over. Methods In a retrospective, multicenter study, w

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Mohanty, Sanjay K., Sarang P. Pedgaonkar, Ashish Kumar Upadhyay, et al. "Awareness, treatment, and control of hypertension in adults aged 45 years and over and their spouses in India: A nationally representative cross-sectional study." PLOS Medicine 18, no. 8 (2021): e1003740. http://dx.doi.org/10.1371/journal.pmed.1003740.

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Background Lack of nationwide evidence on awareness, treatment, and control (ATC) of hypertension among older adults in India impeded targeted management of this condition. We aimed to estimate rates of hypertension ATC in the older population and to assess differences in these rates across sociodemographic groups and states in India. Methods and findings We used a nationally representative survey of individuals aged 45 years and over and their spouses in all Indian states (except one) in 2017 to 2018. We identified hypertension by blood pressure (BP) measurement ≥140/90 mm Hg or self-reported

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Alvarez Reguera, C., D. Martínez-López, L. Sanchez Bilbao, et al. "AB0458 SYSTEMIC TREATMENT IN BEHÇET’S DISEASE ACCORDING TO CLINICAL PHENOTYPES. STUDY OF 111 PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1527.2–1528. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5005.

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Background:Behçet’s disease (BD) is a multisystemic vasculitis. Different clinical phenotypes can be distinguished. Systemic corticosteroids are the most used drugs in BD. Conventional and biological immunosuppressants (IS) may also be used.Objectives:To evaluate the systemic treatment of BD according to clinical domains.Methods:Study of all consecutive 111 patients diagnosed with definitive or possible BD by expert rheumatologists in a well-defined population of Northern Spain, between 1980 and 2019. Most of them met the International Criteria for BD (ICBD) (1).Results:We studied 111 patients

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Malykin, Grigorii B., and Vera I. Pozdnyakova. "On inconsistencies in the work of P Maraner (reply to comment [Usp. Fiz. Nauk 186 793 2016] to the paper "Quadratic Sagnac effect — the influence of gravitational potential of Coriolis force on the phase difference between the arms of a rotating Michelson interferometer (an explanation of D C Miller's experimental results, 1921—1926)" (Usp. Fiz. Nauk 185 431 (2015) [Phys. Usp. 58 398 (2015)])." Uspekhi Fizicheskih Nauk 186, no. 7 (2016): 796–98. http://dx.doi.org/10.3367/ufnr.2016.02.037737.

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Rivera Teran, V., M. Pérez Rodríguez, D. Alpizar-Rodriguez, et al. "AB1229 SAFETY OF BIOSIMILAR ETANERCEPT IN THE TREATMENT OF RHEUMATIC DISEASES: DATA FROM THE MEXICAN ADVERSE EVENTS REGISTRY (BIOBADAMEX)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1905.1–1906. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3819.

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Background:Access to biosimilar drugs in Mexico started on 2014. Although biosimilar drugs safety has proved comparability to originator drugs on trials, information about its safety on real-life data is limited.Objectives:To compare safety in terms of adverse events of biosimilar etanercept (BEt) to originator etanercept (OEt) using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican cohort that collects the information of biologic and biosimilar drugs used in patients with rheumatic diseases in public and private practice since 2016. Patients enr

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Jácomo, Rafael H., Raul Melo, Fernanda Souto, et al. "Clinical Features and Outcome of 148 Patients with Acute Promyelocytic Leukemia in Brazil." Blood 108, no. 11 (2006): 3326. http://dx.doi.org/10.1182/blood.v108.11.3326.3326.

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Abstract Acute Promyelocytic Leukemia (APL) is a distinct subtype of acute myeloid leukemia (AML) which has a high prevalence in Latinos as well as a different distribution of PML breakpoints with a higher incidence of bcr1 isoform. We describe here the characteristics and outcome of 148 consecutive patients, from 11 centers in Brazil. Induction consisted of ATRA and anthracyclines (ida or daunorubicin). All centers used anthracyclines in consolidation but association with AraC was variable. Maintenance was based on low dose chemotherapy, except in 2 centers, which were excluded from survival

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Niewisch, Marena R., Neelam Giri, Lisa J. McReynolds, et al. "Disease Progression and Outcomes in Patients with Telomere Biology Disorders." Blood 136, Supplement 1 (2020): 19–20. http://dx.doi.org/10.1182/blood-2020-136851.

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Dyskeratosis congenita and related telomere biology disorders (DC/TBDs) are multisystem illnesses caused by germline pathogenic variants (PV) in telomere biology genes resulting in very short telomeres. The inheritance varies and includes autosomal dominant (AD), autosomal recessive (AR) and X-linked (XLR) disease. Young patients may present with bone marrow failure (BMF) and the mucocutaneous triad of dysplastic nails, abnormal skin pigmentation, and oral leukoplakia, whereas adults may be identified with isolated BMF, pulmonary fibrosis (PF), or liver disease. In addition to BMF, DC/TBDs are

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Ludvíková, H., and J. Suchá. "First Report of Little Cherry Disease from Sweet Cherry (Prunus avium) and Sour Cherry (P. cerasus) in the Czech Republic." Plant Disease 95, no. 9 (2011): 1197. http://dx.doi.org/10.1094/pdis-12-10-0868.

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Little cherry disease (LChD), a virus disease of sweet (Prunus avium) and sour cherries (P. cerasus), is caused by members of the Closteroviridae family. Symptoms are especially visible on fruits and leaves. Leaves become red or bronze in late summer and fall. Fruit are small, angular, and pointed. Fruits are unmarketable due to a characteristic bitter flavor. LChD also causes reduction of yield (1). Sweet and sour cherries are the second (after apples) most often grown fruit species in the Czech Republic. Since LChD occurred in Germany (1) and Poland (2) in 2007 and 2008, sweet and sour cherr

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Murray, Joanna, Roy Head, Sophie Sarrassat, et al. "Modelling the effect of a mass radio campaign on child mortality using facility utilisation data and the Lives Saved Tool (LiST): findings from a cluster randomised trial in Burkina Faso." BMJ Global Health 3, no. 4 (2018): e000808. http://dx.doi.org/10.1136/bmjgh-2018-000808.

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BackgroundA cluster randomised trial (CRT) in Burkina Faso was the first to demonstrate that a radio campaign increased health-seeking behaviours, specifically antenatal care attendance, health facility deliveries and primary care consultations for children under 5 years.MethodsUnder-five consultation data by diagnosis was obtained from primary health facilities in trial clusters, from January 2011 to December 2014. Interrupted time-series analyses were conducted to assess the intervention effect by time period on under-five consultations for separate diagnosis categories that were targeted by

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