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Journal articles on the topic '794.4 1:373.3.015 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Pranab, Ghosh, and Chakraborty Prasanta. "Reaction of 2-bromo-3-keto triterpenoids Deoxygenation and simultaneous debromination by Huang-Minion reduction condition." Journal of Indian Chemical Society Vol. 90, Apr 2013 (2013): 519–24. https://doi.org/10.5281/zenodo.5771267.

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Department of Chemistry, University of North Bengal, Darjeeling-734 013, West Bengal, India <em>E-mail</em> : pizy12@yahoo.com     Fax : 91-353-2699001 <em>Manuscript received 11 November 2010, revised 09 March 2012, accepted 07 June 2012</em> On heating 2α-bromo/2,2-dibromo lupanone (1/1a) and 2α-bromo/4α-bromo friedelin (2/2a) with diethylene glycol and hydrazine hydrate (Huang-Minion modified Wolff-Kishner reaction) under reflux produced lupane (3) and-friedelane (4), respectively.  

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Bauman, Glenn, Mohammed Rashid, Deanna L. Langer, et al. "A prospective provincial registry of PSMA PET CT for recurrent prostate cancer (PREP): Results for 4135 men." Journal of Clinical Oncology 43, no. 5_suppl (2025): 35. https://doi.org/10.1200/jco.2025.43.5_suppl.35.

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35 Background: PREP was initiated in Ontario to provide access and characterize performance of PSMA PET CT among men with recurrent prostate cancer after primary definitive treatment (RP or RT). Methods: Between 03/18 and 09/22, 4135 men were accrued. Men were enrolled and imaged with 18F-DCFPyL at 1 of 6 participating sites within 1 of 6 clinical cohorts. Standardized reports delineated sites of recurrence and post PET management changes. Linkage to provincial databases allowed estimation of overall survival and utilization of salvage radiotherapy after PET. Results: Median follow-up was 1.8

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Müller, Franz, Michael Galler, Michael Zellner, et al. "Total Hip Arthroplasty for Hip Fractures: Time to Surgery With Respect to Surgical Revision, Failure, and Mortality." Geriatric Orthopaedic Surgery & Rehabilitation 10 (January 1, 2019): 215145931881816. http://dx.doi.org/10.1177/2151459318818162.

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Introduction: There are increasing demands to perform surgery of hip fractures without delay. However, few studies have assessed the time to surgery in relation to outcome measurements. Methods: A total of 643 consecutive patients with a minimum age of 60 years underwent total hip arthroplasty (THA) for an intracapsular hip fracture. For this retrospective case series, demographic data and the outcome measurements—(1) any surgical revision, (2) implant failure, and (3) mortality—were documented from a prospective clinical database. The time from admission to surgery was also documented prospec

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Hoque, Md Ikram Ul, Andrew Gibson, and Scott Donne. "SnO₂-QDs/Rgo Nanocomposites for Lithium Ion Battery Anodes." ECS Meeting Abstracts MA2022-02, no. 7 (2022): 2519. http://dx.doi.org/10.1149/ma2022-0272519mtgabs.

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SnO2 is one of the most efficient materials for lithium ion battery (LIBs) anodes as it can theoretically provide a reversible capacity of 790 mAh/g (graphite, 372 mAh/g) for alloying reaction with lithium ion [(i) SnO 2 + 4 Li+ + 4e - = 2Li 2 O + Sn, (ii) Sn + xLi+ + xe- = LixSn (0 ≤ x ≤ 4.4)] during charge-discharge process [1]. In addition, SnO2 shows lowest operating potentials (average charge and discharge potentials: 0.3 V and 0.5 V vs. Li/Li+, respectively) in comparison with other transition metal oxides, facilitating a higher energy density when a full cell is constructed [2]. However

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Molina Collada, J., F. Sánchez-Alonso, C. Bohórquez, et al. "OP0138 RISK OF CANCER AFTER BIOLOGIC AND TARGETED SYNTHETIC DMARDS INITIATION IN PATIENTS WITH RHEUMATIC DISEASES AND A HISTORY OF PRIOR MALIGNANCY: DATA FROM THE BIOBADASER REGISTRY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 88.2–89. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5030.

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BackgroundPatients with a history of cancer are routinely excluded from randomized controlled trials. As consequence, data on the safety of biologic disease modifying antirheumatic drugs (bDMARDS) and targeted synthetic (ts) DMARDs are limited. Although real world data from various national registries have not provided evidence of increased cancer recurrence, additional data from real-world registries may help to confirm safety of non-TNFi bDMARDs and tsDMARDs regarding cancer recurrence to guide treatment decisions.ObjectivesTo compare the risk of incident malignancy with exposure to differen

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Oh, H. J., M. K. Kim, Y. H. Fibrianto, et al. "337 EFFECTS OF CANINE SYNTHETIC OVIDUCT FLUID MEDIUM SUPPLEMENTED WITH THE VARIOUS ENERGY SUBSTRATES ON IN VITRO MATURATION OF CANINE OOCYTES." Reproduction, Fertility and Development 18, no. 2 (2006): 276. http://dx.doi.org/10.1071/rdv18n2ab337.

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In most mammals, maturation occurs within the ovarian follicle, and preovulatory oocytes are ovulated and ready for fertilization within the oviduct. In contrast, bitch ovulate primary oocytes, over a three day period, undergo both maturation and fertilization within the oviduct. The present study was conducted to evaluate the effects of canine synthetic oviduct fluid (cSOF) supplemented with the various energy substrates on in vitro maturation of canine oocytes. Oocytes were recovered by mincing ovaries collected after ovariohysterectomy in bitches at the follicular stage. Only oocytes with m

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Spinale, F. G., M. Tomita, J. L. Zellner, J. C. Cook, F. A. Crawford, and M. R. Zile. "Collagen remodeling and changes in LV function during development and recovery from supraventricular tachycardia." American Journal of Physiology-Heart and Circulatory Physiology 261, no. 2 (1991): H308—H318. http://dx.doi.org/10.1152/ajpheart.1991.261.2.h308.

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Chronic supraventricular tachycardia (SVT) causes left ventricular (LV) dYsfunction and dilatation. Termination of SVT appears to improve symptoms of congestive heart failure. However, the structural events that occur during development and regression of SVT-induced cardiomyopathy are unknown. Accordingly, LV function (simultaneous echocardiogram-catheterization) and collagen content and distribution were measured in pigs (23-25 kg) assigned to three groups: 1) rapid atrial pacing (240 beats/min) for 3 wk (SVT, n = 10); 2) SVT for 3 wk, followed by deactivation of the pacemaker and a 4-wk reco

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1308.2–1309. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Shiota, Masakazu, Pietro Galassetti, Kayano Igawa, Doss W. Neal, and Alan D. Cherrington. "Inclusion of low amounts of fructose with an intraportal glucose load increases net hepatic glucose uptake in the presence of relative insulin deficiency in dog." American Journal of Physiology-Endocrinology and Metabolism 288, no. 6 (2005): E1160—E1167. http://dx.doi.org/10.1152/ajpendo.00391.2004.

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The effect of small amounts of fructose on net hepatic glucose uptake (NHGU) during hyperglycemia was examined in the presence of insulinopenia in conscious 42-h fasted dogs. During the study, somatostatin (0.8 μg·kg−1·min−1) was given along with basal insulin (1.8 pmol·kg−1·min−1) and glucagon (0.5 ng·kg−1·min−1). After a control period, glucose (36.1 μmol·kg−1·min−1) was continuously given intraportally for 4 h with (2.2 μmol·kg−1·min−1) or without fructose. In the fructose group, the sinusoidal blood fructose level (nmol/ml) rose from <16 to 176 ± 11. The infusion of glucose alone (the c

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Cappellini, Maria-Domenica, John Porter, Raffaella Origa та ін. "A Phase 2a, Open-Label, Dose-Finding Study To Determine The Safety and Tolerability Of Sotatercept (ACE-011) In Adults With Beta (β)-Thalassemia: Interim Results". Blood 122, № 21 (2013): 3448. http://dx.doi.org/10.1182/blood.v122.21.3448.3448.

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Abstract Background Beta (β)-thalassemia is characterized by ineffective erythropoiesis leading to anemia, bone marrow erythroid hyperplasia, iron overload, and organ failure. Sotatercept (ACE-011) is a novel and first-in-class activin type IIA receptor (ActRIIA) fusion protein that increases the release of mature erythrocytes into circulation by acting mainly on late-stage erythropoiesis (Carrancio S, et al. Blood. 2012;120:abstract 372). Clinical data in healthy volunteers have shown that treatment with sotatercept results in increased red blood cell (RBC) parameters, including hemoglobin le

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Castrejon, I., J. Molina Collada, C. Perez-Garcia, et al. "POS1439 CANCER IN PATIENTS WITH RHEUMATIC DISEASES EXPOSED TO DIFFERENT BIOLOGIC AND TARGETED SYNTHETIC DMARDS IN REAL-WORLD CLINICAL PRACTICE: DATA FROM A MULTICENTER REGISTER." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1063. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3834.

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BackgroundExtensive evidence has confirmed no increased risk of cancer associated to either conventional synthetic DMARDs or anti-TNF in patients with rheumatic diseases. The risk of cancer in biologic (bDMARDs) different to anti-TNF and targeted synthetic (tsDMARDs) is considerably less investigated. As new therapies are emerging, more data in real-world registries are needed to confirm safety in other treatment groups.ObjectivesTo compare the risk of cancer of tsDMARDs and other bDMARDs versus anti-TNF in patients with rheumatic diseases.MethodsData of patients enrolled in BIOBADASER 3.0 up

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Ulyanova, Tatiana, Ena R. Banerjee, Gregory V. Priestley, Linda Scott, and Thalia Papayannopoulou. "Migration Defects of Leukocytes from Alpha4 or Beta2 Integrin-Deficient Mice during Aseptic Peritonitis." Blood 104, no. 11 (2004): 2387. http://dx.doi.org/10.1182/blood.v104.11.2387.2387.

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Abstract Leukocyte migration to the inflammatory sites involves a dynamic and coordinated sequence of adhesion/ migration events, in which the α4 and β2 integrins in leukocytes play critical roles. In a model of aseptic peritonitis, normal mice respond with an initial influx of neutrophils followed by later recruitment of mononuclear cells. Previous studies used antibodies to inhibit α4 integrins in this model and provided only early observations (up to 24 hrs). Events at later stages were not addressed. To clarify the role of α4 integrins in this process, we induced aseptic peritonitis in α4-

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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.

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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term antico

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Kulkarni, Samar, Adrian Bloor, Mike Dennis, et al. "Prediction Model to Evaluate Engraftment Kinetics Following Stem Cell Transplantation." Blood 144, Supplement 1 (2024): 3496. https://doi.org/10.1182/blood-2024-211021.

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Introduction: Early engraftment following allogeneic or autologous stem cell transplant (AlloSCT or AutoSCT) reduces the risk of morbidity, hospital stay and infection related mortality. Engraftment kinetics are determined by CD34 cell dose and dose of 2x106/kg is considered as minimum to safely perform AutoSCT. Higher doses of CD34 in AlloSCT may be associated with better outcome but increases the risk of cGVHD. There is limited information about safety to use CD34 dose below 4x106/kg in AlloSCT Methods: Engraftment kinetics were analysed in 1056 patients (AlloSCT: 405, AutoSCT: 540, CART: 11

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Kucha, P., D. Walkiewicz, P. Wieszczy, J. Reguła, and E. Zagórowicz. "OP21 COVID-19 morbidity/mortality and vaccination against SARS-CoV-2 in patients with Inflammatory Bowel Disease in Poland: Nationwide Data." Journal of Crohn's and Colitis 17, Supplement_1 (2023): i29—i30. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0021.

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Abstract Background According to the international recommendations, patients with inflammatory bowel disease (IBD) should be vaccinated against SARS-CoV-2 at the earliest opportunity to do so. The aim of this study was to assess the morbidity and mortality from COVID-19 in the adult IBD population in Poland with respect to their vaccination status. Methods We conducted a retrospective analysis of administrative health claims collected by the National Health Fund, the sole public payer in Poland. We identified adult IBD patients as of December 31th, 2021 who had at least two or more records wit

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di Mauro, Pierluigi, Rebecca Pedersini, Fausto Petrelli, et al. "Abstract P5-18-15: Gastrointestinal toxicity of antibody-drug conjugates (ADCs) in metastatic breast cancer: A pooled analysis." Cancer Research 82, no. 4_Supplement (2022): P5–18–15—P5–18–15. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-18-15.

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Abstract Introduction. Antibody-drug conjugates (ADCs) represent a new class of molecular-targeted drugs, which are being developed to selectively target tumor cells and minimize toxicities. Three ADCs, namely trastuzumab emtansine (TDM-1), sacituzumab govitecan, and trastuzumab deruxtecan, are currently approved for the treatment of metastatic breast cancer (MBC). Acute gastrointestinal toxicities are relatively frequent with these agents. We performed a pooled analysis evaluating gastrointestinal adverse events (AEs) in patients with MBC treated with ADCs. Methods. PubMed, Embase, and the Co

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Winthrop, K., M. H. Buch, J. Curtis, et al. "POS0092 HERPES ZOSTER IN THE FILGOTINIB RHEUMATOID ARTHRITIS PROGRAM." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 255.1–256. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1408.

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Background:The once daily, oral Janus kinase (JAK)-1 preferential inhibitor filgotinib (FIL) improved signs and symptoms of rheumatoid arthritis (RA) in phase (P)3 trials.1-3 Patients (pts) with RA have increased herpes zoster (HZ) reactivation risk vs the general population. JAK inhibition is associated with increased infection incidence, including HZ.4Objectives:To assess long-term safety of FIL across the global clinical program with respect to HZ.Methods:Pts meeting 2010 ACR/EULAR RA criteria in a pooled analysis of P2 DARWIN 1–2 (D1–2), P3 FINCH 1–3 (F1–3), and long-term extension studies

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Musicus, Aviva A., Christina A. Roberto, Alyssa J. Moran, Sarah Sorscher, Eva Greenthal, and Eric B. Rimm. "Effect of Front-of-Package Information, Fruit Imagery, and High–Added Sugar Warning Labels on Parent Beverage Choices for Children." JAMA Network Open 5, no. 10 (2022): e2236384. http://dx.doi.org/10.1001/jamanetworkopen.2022.36384.

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ImportanceFruit drinks are widely consumed by young children, and many parents mistakenly believe that these drinks are healthy, potentially due to front-of-package claims and imagery. Research is needed on the influence of this marketing and how labeling regulations could change behavior.ObjectiveTo assess the effects of a front-of-package 100% vitamin C claim, fruit imagery, percentage juice and teaspoons of added sugar disclosures, and high–added sugar warnings on parents’ choices, knowledge, and perceptions of beverages.Design, Setting, and ParticipantsThis randomized clinical trial was co

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Aletaha, D., R. Westhovens, B. Combe, et al. "POS0676 EFFICACY AND SAFETY OF FILGOTINIB IN PATIENTS AGED ≥75 YEARS: A POST HOC SUBGROUP ANALYSIS OF THE FINCH 4 LONG-TERM EXTENSION (LTE) STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 612.2–613. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1563.

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BackgroundFilgotinib (FIL) is a Janus kinase 1 preferential inhibitor for the treatment of moderate to severe rheumatoid arthritis (RA)1. The recommended dose for adults with RA is 200 mg (FIL200); however, a starting dose of 100 mg (FIL100) is recommended for those aged ≥75 years (y) in view of limited clinical experience1. An important consideration is the generally higher incidence of adverse events (AEs) in the elderly due to comorbidities.ObjectivesTo evaluate the efficacy and safety of FIL100 and FIL200 in patients with RA aged ≥75 y.MethodsFINCH 4 (NCT03025308) is an ongoing phase 3 ope

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Dimopoulos, Meletios Athanasios, Mohamad Hussein, Arlene S. Swern, and Donna M. Weber. "Long-Term Outcomes and Safety of Continuous Lenalidomide Plus Dexamethasone (Len+Dex) Treatment in Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM)." Blood 118, no. 21 (2011): 2929. http://dx.doi.org/10.1182/blood.v118.21.2929.2929.

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Abstract Abstract 2929 Background: Two pivotal phase 3 trials (MM-009 and MM-010) randomized 704 pts to assess Len+Dex vs placebo plus dexamethasone (Dex) in RRMM. The results demonstrated the significant overall survival (OS) benefit of Len+Dex vs Dex (38.0 vs 31.6 mos; p =.045) despite crossover of 48% of Dex pts to the Len+Dex arm at unblinding or progression (Dimopoulos MA et al. Leukemia 2009;23 :2147-52). This is an analysis of the long-term outcomes and safety of continuous Len+Dex treatment. Methods: This retrospective analysis pooled pts treated with Len+Dex in MM-009 and MM-010, with

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Nurani, Yuliani, Niken Pratiwi, Robinson Situmorang, and Ni Gusti Ayu Made Yeni Lestari. "Children’s Character Learning Model Based on Indonesian Local Wisdom: Implemented to Early Childhood Education in Play Centers." JPUD - Jurnal Pendidikan Usia Dini 18, no. 1 (2024): 99–111. http://dx.doi.org/10.21009/jpud.181.07.

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Character education can equip young children to become Indonesia's golden generation who are superior and skilled in noble work. This research aims to produce an early childhood character learning model based on local Indonesian wisdom through the Playing Center title which will be implemented at Early Childhood Education Institutions (ECE) in Indonesia. This research method uses the steps of the Borg and Gall research and development model. The subjects in this research were 30 teachers from five ECE institutions in the DKI Jakarta area. The data used as the basis for building a framework for

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Kiltz, U., P. Sfikakis, N. Gullick, et al. "POS1053 LONG-TERM RETENTION, EFFECTIVENESS AND SAFETY OF SECUKINUMAB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS OR ANKYLOSING SPONDYLITIS: RESULTS FROM THE OBSERVATIONAL SERENA STUDY." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 846–47. http://dx.doi.org/10.1136/annrheumdis-2022-eular.2673.

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BackgroundSERENA is an ongoing, longitudinal, observational study of more than 2900 patients (pts) with moderate to severe psoriasis, active psoriatic arthritis (PsA), and ankylosing spondylitis (AS) conducted at 438 sites across Europe with an expected duration of up to 5 years.1,2ObjectivesWe report long-term results (at least 3 years follow up) on secukinumab (SEC) retention, effectiveness and safety in pts with active PsA or AS from the SERENA study.MethodsThis analysis includes data of 524 PsA and 473 AS pts enrolled in the study and followed up for at least 3 years. Pts (aged ≥18 years)

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Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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AYANKOSO, Micheal Taiwo, Damilola Miracle OLUWAGBAMILA, and Olugbenga Samson ABE. "EFFECTS OF ACTIVATED CHARCOAL ON LIVESTOCK PRODUCTION: A REVIEW." Slovak Journal of Animal Science 56, no. 01 (2023): 46–60. http://dx.doi.org/10.36547/sjas.791.

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Aerts, R. (1997). Nitrogen partitioning between resorption and decomposition pathways: a trade-off between nitrogen use efficiency and litter decomposability? Oikos, 80(3), 603−406. Ahmedna, M., Marshall, W. E. & Rao, R. O. (2000). Granular Activated Carbons from Agricultural By-Products: Preparation, Properties, and Application in Cane Sugar Refining. LSU AgCenter: Bulletin Number 869. Albiker, D. & Zweifel, R. (2019). Pflanzenkohle im Futter oder in der Einstreu und ihre Wirkung auf die Stickstoffretention und Leistung von Broilern. Wissenschaftstagung Ökologischer Landbau. Kassel: S

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Burkhart, Scott O., Christine Ellis, and Troy M. Smurawa. "ACUTE PERFORMANCE ON A VESTIBULAR AND OCULAR MOTOR SCREENER AND RECOVERY FOLLOWING CONCUSSION." Orthopaedic Journal of Sports Medicine 7, no. 3_suppl (2019): 2325967119S0013. http://dx.doi.org/10.1177/2325967119s00136.

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Background: Concussion injuries are synonymous with vestibular impairments and symptoms include dizziness, impaired balance, and problems with gaze stability (Covassin et al., 2014). Common ocular motor impairments after a concussion include convergence/accommodative insufficiencies and saccadic dysfunction (Mucha et al., 2014). Vestibular and ocular motor impairments have been linked to worse outcomes following concussion (Pearce et al., 2015), including prolonged recovery (Corwin et al., 2015). The purpose of the current study was to determine which VOMS impairments were linked with longer r

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Mease, P. J., A. Deodhar, D. Van der Heijde, et al. "OP0227 EFFICACY OF DEUCRAVACITINIB, AN ORAL, SELECTIVE TYROSINE KINASE 2 INHIBITOR, IN MUSCULOSKELETAL MANIFESTATIONS OF ACTIVE PSORIATIC ARTHRITIS IN A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 137–38. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2653.

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Background:Tyrosine kinase 2 (TYK2) is an intracellular kinase that mediates IL-23, IL-12, and IFNα/β signaling. Deucravacitinib is a novel, oral selective inhibitor of TYK2 acting via the TYK2 regulatory domain. Phase 2 results showed deucravacitinib was efficacious and well tolerated versus placebo (PBO) in patients with active psoriatic arthritis (PsA).Objectives:This analysis further evaluated improvements in musculoskeletal disease manifestations in patients in the Phase 2 PsA trial.Methods:The ongoing Phase 2 trial (NCT03881059) enrolled patients who had a PsA diagnosis for ≥6 months, me

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Alten, R., X. Mariette, R. M. Flipo, et al. "POS0447 PHYSICAL FUNCTION IN PATIENTS WITH RA, STRATIFIED BY SEROSTATUS AND TREATMENT LINE, FOLLOWING SC ABATACEPT: POST HOC ANALYSIS OF AN OBSERVATIONAL, 2-YEAR STUDY CONDUCTED IN ROUTINE CLINICAL PRACTICE (ASCORE)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 453–54. http://dx.doi.org/10.1136/annrheumdis-2021-eular.903.

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Background:RA is characterised by the production of autoantibodies, including RF and anti-citrullinated protein antibodies (ACPAs).1 Seropositive disease is associated with poorer prognosis in patients with RA,2 and response to different treatments has been shown to vary based on ACPA status.3 ASCORE (Abatacept SubCutaneOus in Routine Clinical PracticE; NCT02090556) was a 2-year, observational, prospective, multicentre study of SC abatacept for the treatment of RA.4Objectives:This post hoc analysis of the ASCORE study evaluated patient-reported outcomes, assessed using HAQ-DI, by RF/ACPA seros

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Квітіньйо Макарена Мартінез, Соріано Федеріко Ґонзало, Яйченко Вірджинія, Стіб Бренда, and Барейро Хуан Пабло. "Predictors of Picture Naming and Picture Categorization in Spanish." East European Journal of Psycholinguistics 6, no. 1 (2019): 6–18. http://dx.doi.org/10.29038/eejpl.2019.6.1.cui.

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The aim of this paper was to identify which psycholinguistic variables are better predictors of performance for healthy participants in a picture naming task and in a picture categorization task. A correlation analysis and a Path analysis were carried out. The correlation analysis showed that naming accuracy and naming latency are significant and positively correlated with lexical frequency and conceptual familiarity variables, whereas they are negatively correlated with H index. Reaction times in the categorization task were negatively correlated with lexical frequency and conceptual familiar

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Curtis, Susanna A., Neeraja Danda, Zipora Etzion, Hillel W. Cohen, and Henny H. Billett. "Steady State Predictors of Mortality in Adults with Sickle Cell Disease." Blood 124, no. 21 (2014): 1388. http://dx.doi.org/10.1182/blood.v124.21.1388.1388.

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Abstract Background: With improved treatment modalities, longevity for sickle cell disease (SCD) is increasing. Yet there is still a subgroup of adult patients whose survival rate has not improved. These patients, if well defined by evidence based decisions, might be those for whom more aggressive disease modifying therapy would be appropriate. Methods: We identified all patients with SS/Sβ0 seen at our medical center in 2002 whom we were still following in 2012 as well as those who had died between 2002 and 2012. Patients with SC and Sβ+ thalassemia were excluded. ED, clinic, and inpatient ad

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Rajadurai, Pathmanathan, Tatiana Semiglazova, Alinta Hegmane, et al. "Abstract P5-13-25: PIK3CA registry: A noninterventional, descriptive, retrospective cohort study of PIK3CA mutations in patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC)." Cancer Research 82, no. 4_Supplement (2022): P5–13–25—P5–13–25. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-13-25.

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Abstract Introduction: PIK3CA mutations (mut) occur in ~40% of patients (pts) with HR+, HER2- ABC, and lead to phosphatidylinositol 3-kinase (PI3K) pathway hyperactivation, endocrine resistance, and poor survival in advanced disease. Alpelisib, an α-selective PI3K inhibitor and degrader, demonstrated efficacy in combination with fulvestrant in the Phase III SOLAR-1 trial in pts with PIK3CA-mut HR+, HER2- ABC. Notably, treatment benefit was not seen in pts without PIK3CA-mut tumors. Expert guidelines now recommend testing for PIK3CA mut at advanced diagnosis; however, data on PIK3CA mut prevale

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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Hong, Seung Pyo, Min Jeong Kim, Allison Belette, Youjin Oh, Sukjoo Cho, and Young Kwang Chae. "238 Meta-analysis on the incidence of hyperprogressive disease during immune checkpoint inhibitor therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A254—A256. http://dx.doi.org/10.1136/jitc-2021-sitc2021.238.

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BackgroundHyperprogressive disease (HPD) is a distinct pattern of rapid tumor progression observed in patients with cancer who are undergoing immune checkpoint inhibitor therapy. Despite the growing evidence, a universal definition of HPD remains to be established, and incidence rates vary based on the defining criteria. Therefore, a refinement of currently existing criteria is warranted to better characterize this phenomenon and evaluate its incidence.MethodsTwo independent investigators performed a systematic literature search in EMBASE and MEDLINE using keywords selected in Park et al.1: ch

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Aisyah Durrotun Nafisah, Yuli Kurniawati Sugiyo Pranoto, and Siti Nuzulia. "The Impact of Father Involvement in the Early Childhood Problematic Behavior." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 14–30. http://dx.doi.org/10.21009/jpud.171.02.

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Father's involvement is something that influences the child's problematic behavior. The purpose of this study is to investigate whether father involvement can influence children's problematic behavior. This study used the systematic literature review (SLR) method by referring to 10 valid articles published in the last 10 years with the publication years between 2013 - 2023. The finding of the literature shows that there is a significant impact of father involvement on the children's problematic behavior. The more the father is involved in the children's development, the lower the level of chil

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Dumont, Larry J., James P. AuBuchon, Louise Herschel, Jill Roger, Thayer White, and Adonis Stassinopoulos. "Random Healthy Donor Sera Show Varying Effectiveness in Hemolyzing ABO Incompatible Red Blood Cells." Blood 108, no. 11 (2006): 958. http://dx.doi.org/10.1182/blood.v108.11.958.958.

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Abstract Mixing of allogeneic serum with RBC that are ABO-incompatible is well known to cause lysis of the RBC. However, the severity and extent of such hemolysis may not be the same for every mismatched pairing and is not documented in the literature. We were interested in quantitating the lytic potential of a large panel of normal sera when exposed to ABO-incompatible RBC. We collected 80mL of whole blood in red-top tubes from 110 random healthy subjects (84 female 26 male) with blood Groups A (n=6), AB (n=5), B (n=10) and O (n=89). Sera were prepared by clotting at room temp, frozen in aliq

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Chen, Lei, Dominick Latremouille-Viau, Annie Guerin, Roy Nitulescu, and Patrick Gagnon-Sanschagrin. "Treatment Patterns and Healthcare Costs in Newly Diagnosed Patients with Chronic Myeloid Leukemia Receiving Dasatinib or Nilotinib As First-Line Therapy in the United States: A Retrospective Claims Database Analysis." Blood 126, no. 23 (2015): 1596. http://dx.doi.org/10.1182/blood.v126.23.1596.1596.

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Abstract Background: To date, no studies have directly compared the treatment patterns and economic outcomes of dasatinib and nilotinib as 1st-line therapy for Philadelphia chromosome positive chronic myeloid leukemia in chronic phase (Ph+ CML-CP). This study aimed to address this gap using retrospective claims data. Method: Newly diagnosed adult pts with CML who received dasatinib or nilotinib as 1st-line therapy were identified from 2 large US administrative claims databases (Q1/2010 - Q4/2014). Pts with continuous health plan coverage for ≥6 months before (baseline period) and ≥1 month afte

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Vdovychenko, Yu V., L. O. Omelchenko, A. V. Pysarenko, R. M. Makarchuk, N. M. Fursa, and L. V. Vishnevskiy. "CHARACTERISTIC OF THE TAURIDE TYPE OF SOUTH BEEFCATTLE BREED." Animal Breeding and Genetics 52 (November 1, 2016): 12–17. http://dx.doi.org/10.31073/abg.52.02.

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One of the directions of modern breeding programs for native beef breeds of cattle is organization of activities to preserve genetic variability under control of absorptive pressure of initial breeds and inbreeding level. Therefore, the topical is search of alternative ways of improving genetic potential of productivity and its phenotypic realization based on population monitoring organization, substantiation of theoretical and methodological approaches for determining breeding value and analysis of inheritance and consolidation of main breeding traits in beef cattle. Geographically isolated b

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Ballantyne, C. M., M. Banach, A. L. Catapano, et al. "P5364Safety profile of bempedoic acid: pooled analysis of 4 phase 3 clinical trials." European Heart Journal 40, Supplement_1 (2019). http://dx.doi.org/10.1093/eurheartj/ehz746.0329.

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Abstract Background/Introduction Bempedoic acid (BA), an oral, first-in-class, ATP-citrate lyase inhibitor, lowers low-density lipoprotein cholesterol (LDL-C) in patients who do not achieve sufficient lipid lowering with guideline-recommended first-line therapies. Purpose We evaluated the safety profile of BA in phase 3 trials. Methods Data were pooled from 4 randomised, double-blind, placebo-controlled studies that enrolled patients with hyperlipidaemia who were receiving stable lipid-lowering therapy (LLT; maximally tolerated statins +/− nonstatin therapies) and required additional LDL-C low

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Gossec, L., D. D. Gladman, E. Mcdearmon-Blondell, et al. "AB0550 EFFICACY OF UPADACITINIB IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS AND A LOW OR HIGH SWOLLEN JOINT COUNT: A SUBGROUP ANALYSIS OF 2 PHASE 3 STUDIES (SELECT-PsA 1 AND SELECT-PsA 2)." May 26, 2021. https://doi.org/10.1136/annrheumdis-2021-eular.2127.

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Background:Although most patients with psoriatic arthritis (PsA) enrolled in clinical trials have polyarticular arthritis, patients in clinical practice may present with oligoarthritis. Data on the efficacy of Janus kinase inhibitors in patients with PsA with low joint counts are limited.Objectives:To evaluate the efficacy of upadacitinib (UPA) in subgroups of patients with PsA with a low (baseline swollen joint count [SJC] <5) or high (SJC ≥5) SJC (LSJ or HSJ).Methods:Data were pooled across the SELECT-PsA 11 (non-biologic disease-modifying antirheumatic drug [non-bDMARD] inadequate respon

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Todorov Sakic, Verica, Petar Djuric, Aleksandar Jankovic, et al. "MO644: Comparative Analysis of Survival and Morbidity in Home and Hospital Haemodialysis." Nephrology Dialysis Transplantation 37, Supplement_3 (2022). http://dx.doi.org/10.1093/ndt/gfac077.004.

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Abstract BACKGROUND AND AIMS Many studies have shown that home haemodialysis (HOHD) provides fewer complications and better outcomes as compared with hospital haemodialysis (HHD). The aim of this study was to compare morbidity and survival in patients on HOHD and HHD. METHOD We analysed 26 prevalent HOHD patients who were matched with 52 HHD patients according to sex, age and Davies Comorbidity Index (DCI). DCI is based on seven groups of comorbidities: ischaemic heart disease (IHD), left ventricular dysfunction (LVD), peripheral vascular disease (PVD), malignancy, diabetes mellitus (DM), syst

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Гурбанов, А. Г., А. Б. Лексин, В. М. Газеев, et al. "VARIATIONS IN THE CONTENT OF MACRO- AND MICROELEMENTS IN VERTICAL SECTIONS OF INDUSTRIAL WASTES OF THE FIAGDON TAILING DUMP (REPUBLIC OF NORTH OSSETIA-ALANIA)." Вестник Владикавказского научного центра, no. 1 (March 28, 2019). http://dx.doi.org/10.23671/vnc.2019.1.27285.

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В статье впервые публикуются данные, полученные количественным методом РФА (XRF), о вариациях содержаний макро- и микроэлементов в вертикальных разрезах в захороненных промышленных отходах (по данным бурения трех скважин) Фиагдонского хвостохранилища, на всю его мощность (10 м, 22 м и 31,5 м с востока на запад, соответственно). Хвостохранилище Фиагдонской обогатительной фабрики (ФОФ) расположено в пойме р. Хаником-дон (правый при- ток р. Фиагдон, в 2,5 км к северу от пос. Верхний Фиагдон). Площадь хвостохранилища около 56 000 м2. В нем захоронено, по данным ФОФ, 2,4 млн тонн промышленных отход

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Brunt, Vienna E., Andrew T. Jeckell, Brett R. Ely, Matthew J. Howard, Michael A. Francisco, and Christopher T. Minson. "Passive Heat Stress Prevents Endothelial Ischemia‐Reperfusion Injury in Young Healthy Humans." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.763.20.

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Endothelial ischemia‐reperfusion (I/R) injury is a primary cause of poor outcomes following ischemic events such as heart attack and stroke. Acute interval exercise has recently been shown to protect against brachial artery I/R injury. Passive heat exposure results in many of the same cardiovascular adaptations as exercise (e.g. acute elevations in body core temperature and vascular shear stress as well as chronically improved vascular function). Therefore, we sought to determine whether an acute bout of hot water immersion can also protect against endothelial I/R injury.METHODSNine (5 male, 4

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Shaikh, Nida I., Subramani Poongothai, Mohammad K. Ali, Lydia Chwastiak, and Viswanathan Mohan. "Relationship Between Severity of Depression and Alcohol and/or Tobacco Use Among Adults with Type 2 Diabetes." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.636.41.

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IntroductionSubstantial evidence in western settings support strong associations between current depression and increased risk of current smoking and alcohol use, even among patients with type 2 diabetes. Little is known about the nature of these associations in other settings including India.ObjectiveTo evaluate the relationship between severity of depression and alcohol and tobacco use among adults with type 2 diabetes in India.MethodsSubjects were 404 adults aged 35–74 years with depression and type 2 diabetes participating in the ongoing INTegrating DEPrEessioN and Diabetes TreatmENT (INDE

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Boyko, V. V., V. V. Kritsak, A. L. Sochnieva, V. V. Tkachenko, and O. M. Tishchenko. "A modern view of the problem of treatment of cicatricial stenoses of the trachea." Medicine Today and Tomorrow 93, no. 4 (2024). https://doi.org/10.35339/msz.2024.93.4.bks.

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Ezemba N, Echieh CP, Chime EN, Okorie CO, Okonna FG, Idoko FL, Arua OA. Postintubation tracheal stenosis: Surgical management. Niger J Clin Pract. 2019;22:134-7. DOI: 10.4103/njcp.njcp_288_18. PMID: 3066603. Lale Az, Oz B, Akcan AC, Sozuer EM, Arıkan TB, Gok M. Determination of risk factors causing hypocalcaemia after thyroid surgery. Asian J Surg. 2019;42(9):883-9. DOI: 10.1016/j.asjsur.2018.12.009. PMID: 30685145. Du C, Ma L, Chai N, Gao Y, Niu X, Zhai Y, et al. Factors affecting the effectiveness and safety of submucosal tunneling endoscopic resection for esophageal submucosal tumors origin

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Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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sprotocols. "Assay for quantitative determination of CYP1A1 enzyme activity using 7-Ethoxyresorufin as standard substrate (EROD assay)." December 31, 2014. https://doi.org/10.5281/zenodo.13665.

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Authors: Afshin Mohammadi-Bardbori ### Abstract The activity of the enzyme 7-ethoxy-resorufin-O-deethylase (EROD) has been extensively employed in biomonitoring studies of persistent organic pollutants (POPs) for more than a decade. Although the procedure is simple, convenient, sensitive and accurate. The cytochrome P450 monooxygenase 1A (CYP1A) is induced by several planar toxic compounds and endogenous chemicals, and the induction of this protein is often measured in terms of EROD activity. This protocol describes how to use EROD activity in the prediction of toxicity of chemicals in several

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Ameku, W.A., V.N. Ataide, E.T. Costab, et al. "A pencil-lead immunosensor for the rapid electrochemical measurement of anti-Diphtheria Toxin antibodies." October 30, 2021. https://doi.org/10.5281/zenodo.5628477.

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<strong>Abstract: </strong>Diphtheria is a vaccine-preventable disease, yet immunization can wane over time to non-protective levels. We have developed a low-cost, miniaturized electroanalytical biosensor to quantify anti-diphtheria toxin (DTx) immunoglobulin G (IgG) antibody to minimize the risk for localized outbreaks. Two epitopes specific to DTx and recognized by antibodies generated post-vaccination were selected to create a bi-epitope peptide, biEP, by synthesizing the epitopes in tandem. The biEP peptide was conjugated to the surface of a pencil-lead electrode (PLE) integrated into a po

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sprotocols. "A rapid one-step kinetics-based immunoassay procedure for the highly-sensitive detection of C-reactive protein." December 31, 2014. https://doi.org/10.5281/zenodo.13656.

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Authors: Sandeep Kumar Vashist, Gregor Czilwik, Thomas van Oordt, Felix von Stetten, Roland Zengerle, E. Marion Schneider & John H.T. Luong ### Abstract A rapid one-step kinetics-based sandwich enzyme-linked immunosorbent (ELISA) procedure has been developed for highly-sensitive detection of C-reactive protein (CRP) in less than 30 min. With minimal process steps, the procedure is highly simplified and cost-effective. The analysis only involves sequentially the formation of a sandwich immune complex on capture anti-CRP antibody (Ab)-bound Dynabeads, followed by two magnet-assisted washings

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Yakovleva, Natalia M., Alisa M. Shul’ga, Kristina V. Stepanova та ін. "Микроконусные анодно-оксидные пленки на спеченных порошках ниобия". Kondensirovannye sredy i mezhfaznye granitsy = Condensed Matter and Interphases 22, № 1 (2020). http://dx.doi.org/10.17308/kcmf.2020.22/2536.

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Информация об анодировании спеченных порошков (CП) ниобия ограничена изучением роста барьерных пленок. Формирование наноструктурированной анодной оксидной пленки (АОП) на поверхности частиц порошка должно привести к заметному увеличению удельной поверхности образца и росту химической активности материала. В соответствии с вышесказанным, исследование анодного наноструктурирования спеченных порошков ниобия является актуальной задачей, открывая перспективы создания новых функциональных наноматериалов. Цель статьи – изучение процесса анодирования спеченных порошков Nb во фторсодержащем водном элек

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