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Journal articles on the topic '796.325:378 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Latagliata, R., M. Breccia, P. Fazi, et al. "Long-Term Results of the GIMEMA LAP AIDA 0493 Amended Protocol in Elderly Patients with Acute Promyelocytic Leukemia (APL)." Blood 106, no. 11 (2005): 885. http://dx.doi.org/10.1182/blood.v106.11.885.885.

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Abstract In order to reduce toxicity in elderly patients with newly diagnosed APL, since 3/1997 the Italian cooperative group GIMEMA evaluated an amended AIDA protocol for patients aged &gt; 60 years, consisting of the same induction with ATRA and Idarubicin but only 1st consolidation course (Idarubicin + Cytarabine), followed by 2 years maintenance with ATRA alone. Up to now, 56 patients (25 males and 31 females, median age 66.2 years, 46 with PS 0-1 and 10 with PS 2) are fully evaluable. At onset, according to GIMEMA-PETHEMA risk score, 18 were low-risk(32.5%), 31 intermediate risk (55%)

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Wood, Henry, Lauren Jamieson, Charles Manogaran, et al. "Correlation between the Integrated MDS Flow Cytometry Score and Genomic Abnormalities - a Single Centre Analysis from King's College Hospital." Blood 144, Supplement 1 (2024): 6751. https://doi.org/10.1182/blood-2024-211268.

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Myelodysplastic syndromes (MDS) are diagnosed based on peripheral cytopenias, morphological dysplasia and recurrent genomic abnormalities. Gene variants are found in approximately 90% of cases and cytogenetic abnormalities in 50% (Arber et al, 2022). Genomic abnormalities are key to diagnosis and prognosis (Bernard et al, 2022). The European Leukemia Net international MDS flow cytometry working group has recommended an integrated flow cytometry score (iFS) to support diagnosis of MDS (Oelshlaegel et al 2021; van de Loosdrecht et al, 2021). The score identifies three categories based on the num

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Shaib, Walid Labib, Ali Roberts, Katerina Mary Zakka, et al. "Blood-based next-generation sequencing analysis of neuroendocrine tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 4110. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4110.

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4110 Background: Neuroendocrine tumors (NET) comprise around 2% of all malignant tumors of the gastrointestinal system. The genomic landscape of NET has not been well studied. The aim of this study was to confirm the feasibility of next generation sequencing (NGS) using ctDNA in NET and characterize common alterations in the genomic profile. Methods: Molecular alterations in 114 plasma samples from 114 patients with NET using clinical-grade NGS of ctDNA (Guardant360Ò) across multiple institutions were evaluated. The test detects single nucleotide variants in 54-73 genes, copy number amplificat

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Jaenudin, M., and Ali Hamdan. "Penilaian Dampak Zakat, Infak, Sedekah Terhadap Kemiskinan Spiritual Dan Material Penerima Manfaat Laznas LMI: Pendekatan CIBEST." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 3 (2022): 362–78. http://dx.doi.org/10.20473/vol9iss20223pp362-378.

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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikat

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Jaenudin, M., and Ali Hamdan. "Penilaian Dampak Zakat, Infak, Sedekah Terhadap Kemiskinan Spiritual Dan Material Penerima Manfaat Laznas LMI: Pendekatan CIBEST." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 3 (2022): 362–78. http://dx.doi.org/10.20473/vol9iss20223pp362-378.

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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikat

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De Agustin, J. J., G. Añez, D. Reina-Sanz, et al. "AB1116 APREMILAST IN PSORIATIC ARTHRITIS. ULTRASOUND ANALYSIS (JOINT-ENTHESES-UNGUEAL INDEX) OF THE EFFICACY AND VARIABLES CORRELATION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1787–88. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1397.

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BackgroundWe conducted a study using ultrasonography (US) to evidence inflammatory changes (joint-enthesis-ungueal) in active PsA (aPsA) patients who started Apremilast (A) in clinical practice.ObjectivesObtain a 20, 50, 70 % reduction in the US index (UIC) at 12 months, and study correlation between variables.MethodsPhase IV, multicenter, prospective and open-label clinical trialconductedin 9 centresfrom 2018 to 2021. All patients signed the informed consent. Approval by the ethical committee was obtained, code PSA-PI-006421. PsA patients (≥ 2 swollen joints), ≥ 2 joint US synovitis and ≥ 1 U

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Waikel, Rebekah L., Amna A. Othman, Tanviben Patel, et al. "Recognition of Genetic Conditions After Learning With Images Created Using Generative Artificial Intelligence." JAMA Network Open 7, no. 3 (2024): e242609. http://dx.doi.org/10.1001/jamanetworkopen.2024.2609.

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ImportanceThe lack of standardized genetics training in pediatrics residencies, along with a shortage of medical geneticists, necessitates innovative educational approaches.ObjectiveTo compare pediatric resident recognition of Kabuki syndrome (KS) and Noonan syndrome (NS) after 1 of 4 educational interventions, including generative artificial intelligence (AI) methods.Design, Setting, and ParticipantsThis comparative effectiveness study used generative AI to create images of children with KS and NS. From October 1, 2022, to February 28, 2023, US pediatric residents were provided images through

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Patenaude, Jan, Gustavo Zarini, Michael McLean, and Susan Linke. "Effectiveness of a Tailored Dietary Program in Subjects With Fibromyalgia." Current Developments in Nutrition 5, Supplement_2 (2021): 856. http://dx.doi.org/10.1093/cdn/nzab047_019.

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Abstract Objectives We examined the effects of the Lifestyle Eating and Performance (LEAP) program to alleviate fibromyalgia-related symptoms. Methods The retrospective study included de-identified data of 33 subjects with fibromyalgia. Dietitians used the in-vitro Leukocyte Activation Assay-MRT (LAA-MRT) blood test results to develop the tailored LEAP program for each subject. The LAA-MRT measures white blood cells reactivity to scale the degree of an adverse immune response to 150 food and food-chemical antigens. The LEAP program is based on the principles of the oligoantigenic dietary appro

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Kretzer, Ryan M., Christopher Chaput, Daniel M. Sciubba, et al. "A computed tomography–based feasibility study of translaminar screw fixation in the upper thoracic spine." Journal of Neurosurgery: Spine 12, no. 3 (2010): 286–92. http://dx.doi.org/10.3171/2009.10.spine09546.

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Object Translaminar screws (TLSs) offer an alternative to pedicle screw (PS) fixation in the upper thoracic spine. Although cadaveric studies have described the anatomy of the laminae and pedicles at T1–2, CT imaging is the modality of choice for presurgical planning. In this study, the goal was to determine the diameter, maximal screw length, and optimal screw trajectory for TLS placement at T1–2, and to compare this information to PS placement in the upper thoracic spine as determined by CT evaluation. Methods One hundred patients (50 men and 50 women), whose average age was 41.7 ± 19.6 year

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Johnston, Kenton J., Michelle Hendricks, Megha Dabas, et al. "Nationwide Availability of and Enrollment in Medicare and Medicaid Dual-Eligible Special Needs Plans With Exclusively Aligned Enrollment." JAMA Health Forum 5, no. 10 (2024): e243546. http://dx.doi.org/10.1001/jamahealthforum.2024.3546.

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ImportanceIn 2021, the Centers for Medicare &amp;amp; Medicaid Services designated a new category of dual-eligible special needs plans (D-SNPs) with exclusively aligned enrollment (receive Medicare and Medicaid benefits through the same plan or affiliated plans within the same organization).ObjectiveTo assess the availability of and enrollment in D-SNPs with exclusively aligned enrollment and to compare the characteristics of beneficiaries enrolled in D-SNPs with exclusively aligned enrollment available vs beneficiaries without such enrollment available.Design, Setting, and ParticipantsFul

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Porter, J., C. Borgna-Pignatti, M. Baccarani, et al. "Iron Chelation Efficiency of Deferasirox (Exjade®, ICL670) in Patients with Transfusional Hemosiderosis." Blood 106, no. 11 (2005): 2690. http://dx.doi.org/10.1182/blood.v106.11.2690.2690.

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Abstract Iron excretion can be calculated according to Angelucci et al (NEJM 2000). As applied to the novel oral iron chelator deferasirox (DSX), chelation efficiency can then be determined as the % iron excretion vs theoretical iron binding capacity of chelator dose: % efficiency = [iron excretion (mg/kg/day)/chelator dose (mg/kg/day)] x [374/56] x 2 x 100 (374 and 56 represent the molecular weights of DSX and iron; factor 2 accounts for the tridentate ligand). In a total of 325 patients with β-thalassemia (n=285) or rare anemias, such as MDS (n=13), DBA (n=14) or other anemias (n=13), includ

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Rivera Teran, V., M. Pérez Rodríguez, D. Alpizar-Rodriguez, et al. "AB1229 SAFETY OF BIOSIMILAR ETANERCEPT IN THE TREATMENT OF RHEUMATIC DISEASES: DATA FROM THE MEXICAN ADVERSE EVENTS REGISTRY (BIOBADAMEX)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1905.1–1906. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3819.

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Background:Access to biosimilar drugs in Mexico started on 2014. Although biosimilar drugs safety has proved comparability to originator drugs on trials, information about its safety on real-life data is limited.Objectives:To compare safety in terms of adverse events of biosimilar etanercept (BEt) to originator etanercept (OEt) using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican cohort that collects the information of biologic and biosimilar drugs used in patients with rheumatic diseases in public and private practice since 2016. Patients enr

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Chamseddine, Sarah, Haniah A. Zaheer, John V. Williams, Judith M. Martin, Anne-Marie Rick, and Hui Liu. "1328. Risk Factors for Severe Influenza Outcomes Among Infants Born Between 2011 and 2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S752. http://dx.doi.org/10.1093/ofid/ofab466.1520.

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Abstract Background Influenza in infancy can cause significant morbidity and mortality. This study aimed to characterize influenza outcomes in infants &lt; ορ = 12 months and identify risk factors for severe infection. Methods A retrospective cohort of infants ≤ 12 months born between 2011-2019 who received longitudinal ambulatory and inpatient care within a multi-facility hospital system and had laboratory-confirmed influenza were included. Perinatal, medical and illness characteristics were described. Risk factors for severe influenza (hospitalization, intensive-care unit (ICU) admission

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Viehman, J. Alex, M. Hong Nguyen, Will Garner, et al. "555. Effectiveness of a Treatment Team on Adherence to Health System Guidelines for Hydroxychloroquine Use During Two Phases of the COVID-19 Epidemic." Open Forum Infectious Diseases 7, Supplement_1 (2020): S343. http://dx.doi.org/10.1093/ofid/ofaa439.749.

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Abstract Background Our hospital system created system guidelines to standardize care across 24 hospitals for COVID-19 treatment during the pandemic. Guidelines changed over time. Hydroxychloroquine (HCQ) was unrestricted during phase 1, then restricted by pharmacy outside of a randomized clinical trial (RCT) during phase 2 (excepting those ineligible for RCTs). Methods This was a prospective study to assess system-wide adherence to COVID-19 treatment guidelines, and to evaluate patient outcomes. Results Of 261 patients, median age was 67 years (IQR 56–76); 49% (129/261) were male, and 45% (11

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Azpiri-López, J. R., I. J. Colunga-Pedraza, D. Á. Galarza-Delgado, et al. "AB0240 RHEUMATOID ARTHRITIS CLINICAL ACTIVITY IS NOT ASSOCIATED TO CARDIOVASCULAR RISK AS MEASURED BY TRADITIONAL RISK SCALES." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1304.2–1305. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3099.

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BackgroundRheumatoid arthritis (RA) patients have a higher cardiovascular risk (CVR) than the general population, being atherosclerotic cardiovascular disease the main cause of mortality [1]. Such increased could be explained by traditional CVR factors and chronic inflammatory state of disease. Clinical activity of disease, which is evaluated by DAS-28, is a parameter that denotes the current inflammatory status. [2]ObjectivesTo compare CVR, by six scales: ACC/AHA ASCVD 2013, Framingham lipids and BMI, SCORE2, QRISK3 and Reynolds risk score, according to clinical activity of RA patients using

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Fiegl, Michael, Andreas Falkner, Michael Fidrik, et al. "Alemtuzumab in B-Cell Prolymphoytic Leukemia (B-PLL) and Richter’s Transformation." Blood 108, no. 11 (2006): 4733. http://dx.doi.org/10.1182/blood.v108.11.4733.4733.

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Abstract Alemtuzumab is the standard therapy for treatment of patients with relapsed/refractory B-CLL. Significant responses have also been documented in the front-line CLL setting, and as well as in first-line therapy of patients with T-PLL, a population with an exceptionally poor prognosis and few available therapeutic options. Limited data available on the therapeutic benefit of alemtuzumab in other aggressive lymphomas such as B-PLL, which is rare, with a heterogeneous clinical course, and often chemoresistant, as well as CLL with Richter’s transformation, which is also characterized by a

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Polizzotto, Mark N., Irini Sereti, Thomas S. Uldrick, et al. "Pomalidomide Induces Expansion of Activated and Central Memory CD4+ and CD8+ T Cells in Vivo in Patients with and without HIV Infection." Blood 124, no. 21 (2014): 4128. http://dx.doi.org/10.1182/blood.v124.21.4128.4128.

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Abstract Background: Despite antiretroviral therapy (ART), people with HIV continue to exhibit immune deficits including failure to fully reconstitute CD4 T cell numbers and function, resulting in increased risks of tumors and infections and reduced response to vaccination. Pomalidomide, a derivative of thalidomide (IMID), has immunomodulatory properties that may be beneficial in this setting. We explored its impact on lymphocyte number and activation in patients with and without HIV treated within a prospective clinical trial for Kaposi sarcoma. Methods: Patients received pomalidomide 5mg ora

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Diamanti-Kandarakis, Evanthia, Giovanna Spina, Chryssa Kouli, and Ilias Migdalis. "Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy." Journal of Clinical Endocrinology & Metabolism 86, no. 10 (2001): 4666–73. http://dx.doi.org/10.1210/jcem.86.10.7904.

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Women with polycystic ovary syndrome who present with hyperandrogenemia, hyperinsulinemia, and insulin resistance appear to be at high risk of cardiovascular disease. Elevated levels of endothelin-1, a marker of vasculopathy, have been reported in insulin-resistant subjects with endothelial dysfunction. Male gender also seems to be an aggravating factor for cardiovascular disease. In this study we investigated endothelin-1 levels in women with polycystic ovary syndrome, and we evaluated the effect of an insulin sensitizer, metformin, on endothelin-1 levels. Plasma endothelin-1 levels were meas

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Tan, Juanyi, Szu-Chun Yang, Michaela A. Dinan, Anne C. Chiang, Cary P. Gross, and Shi-Yi Wang. "Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer." JAMA Network Open 8, no. 6 (2025): e2514519. https://doi.org/10.1001/jamanetworkopen.2025.14519.

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ImportanceTargeted therapies and immunotherapies prolong survival but are associated with high costs for patients with advanced non–small cell lung cancer (aNSCLC). To date, little is known about survival and medication cost by biomarker status in the US.ObjectiveTo estimate survival and medication cost by aNSCLC biomarker status.Design, Setting, and ParticipantsThis retrospective cohort study using Flatiron Health data identified patients diagnosed with aNSCLC from January 1, 2016, through December 31, 2022. Each patient had received at least 1 biomarker test and 1 documented line of therapy;

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Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud

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Curtis, J., I. Mcinnes, P. Rahman, et al. "AB0756 GUSELKUMAB IMPROVED WORK PRODUCTIVITY AND DAILY ACTIVITY IN PATIENTS WITH PSORIATIC ARTHRITIS: RESULTS FROM A PHASE 3 TRIAL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1675.1–1675. http://dx.doi.org/10.1136/annrheumdis-2020-eular.428.

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Background:DISCOVER 2 (DISC 2) is a Phase 3 trial of anti-IL-23-specific mAb guselkumab (GUS) in psoriatic arthritis (PsA) pts, who experience impaired physical function, resulting in disability, work productivity loss, and economic consequences.1Objectives:To evaluate the effect of GUS on impaired work productivity and daily activity in DISC 2 using the Work Productivity and Activity Impairment Questionnaire: Psoriatic Arthritis (WPAI-PsA).Methods:Bio-naïve adults with active PsA despite nonbiologic DMARDs &/or NSAIDs received subcutaneous GUS 100 mg every (q) 4 weeks (W); GUS 100 mg W0,

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Leprêtre, Stephane, Frédéric Maloisel, Didier Kamioner, Christian Berthou, and Hélène Albrand. "Good Usage of Biosimilar Filgrastim: A Subanalysis of the Next Study." Blood 124, no. 21 (2014): 4974. http://dx.doi.org/10.1182/blood.v124.21.4974.4974.

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Abstract Introduction Febrile neutropenia (FN), a major risk factor for morbidity/mortality, is associated with dose delays and/or reductions in potentially cytotoxic chemotherapy (CT) regimens. It is defined as an oral temperature >38.5°C, or two consecutive readings of >38.0°C for 2 h, with an absolute neutrophil count <0.5 x 109/L, or expected to fall below 0.5 x 109/L. Guidelines from the European Organisation for Research and Treatment of Cancer (EORTC) recommend prophylactic use of granulocyte-colony stimulating factor (G-CSF) when using a CT regimen associated with a >20% ri

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Sacha, Tomasz, Joanna Gora-Tybor, Monika Szarejko, et al. "Imatinib Generics in Treatment of Chronic Myeloid Leukemia; A Prospective Observation in Large Cohort of Patients from Polish (PALG) Imatinib Generics Registry." Blood 128, no. 22 (2016): 629. http://dx.doi.org/10.1182/blood.v128.22.629.629.

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Abstract Background: Generic imatinib is already available in several countries. The use of generic imatinib is expected to lower the cost of CML therapy, however the data regarding their efficacy and tolerability in larger populations of CML patients are lacking. Aim: The aim of the study was to evaluate the efficacy and tolerability of imatinib generics in patients suffering from chronic phase CML previously untreated, and in the group of patients switched from branded imatinib to imatinib generics during a one-year of observation. Methods: We report on 726 patients prospectively observed fo

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Nazha, Aziz, David J. Seastone, Tomas Radivoyevitch, et al. "A Novel Prognostic Model in Heavily Treated Patients with Myelodysplastic Syndromes (MDS)." Blood 124, no. 21 (2014): 168. http://dx.doi.org/10.1182/blood.v124.21.168.168.

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Abstract Background The Revised International Prognostic Scoring System (IPSS-R) was developed to risk stratify untreated patients (pts) with MDS. It has since been validated in pts treated with a single line of drug therapy, and has been modified in untreated pts to include mutational data; however, these approaches do not reflect typical MDS pts who receive different types of treatment in different sequences. We propose a prognostic model that incorporates mutational data and predicts outcome in pts with primary and secondary MDS regardless of their initial or subsequent treatments. Methods

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Karrar, Omer, Moazah Iftikhar, Kristen McCullough, et al. "Survival and Prognosis Among 301 Patients with Newly-Diagnosed Acute Myeloid Leukemia Following Venetoclax Plus Hypomethylating Agent Therapy." Blood 142, Supplement 1 (2023): 591. http://dx.doi.org/10.1182/blood-2023-178837.

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Background: Venetoclax (Ven) in combination with hypomethylating agent (HMA) is the preferred treatment for elderly/unfit patients with newly-diagnosed acute myeloid leukemia (AML). Current prognostication for AML is based on European LeukemiaNet (ELN) genetic risk stratification which has limited applicability in patients treated with Ven-HMA ( Blood, 2022). Accordingly, our primary objective was to determine predictors of treatment response and survival outcomes in treatment-naïve AML patients receiving Ven-HMA. Methods: Our study population was recruited from Mayo Clinic (MN, FL, AZ), after

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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Квітіньйо Макарена Мартінез, Соріано Федеріко Ґонзало, Яйченко Вірджинія, Стіб Бренда, and Барейро Хуан Пабло. "Predictors of Picture Naming and Picture Categorization in Spanish." East European Journal of Psycholinguistics 6, no. 1 (2019): 6–18. http://dx.doi.org/10.29038/eejpl.2019.6.1.cui.

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The aim of this paper was to identify which psycholinguistic variables are better predictors of performance for healthy participants in a picture naming task and in a picture categorization task. A correlation analysis and a Path analysis were carried out. The correlation analysis showed that naming accuracy and naming latency are significant and positively correlated with lexical frequency and conceptual familiarity variables, whereas they are negatively correlated with H index. Reaction times in the categorization task were negatively correlated with lexical frequency and conceptual familiar

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Hong, Seung Pyo, Min Jeong Kim, Allison Belette, Youjin Oh, Sukjoo Cho, and Young Kwang Chae. "238 Meta-analysis on the incidence of hyperprogressive disease during immune checkpoint inhibitor therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A254—A256. http://dx.doi.org/10.1136/jitc-2021-sitc2021.238.

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BackgroundHyperprogressive disease (HPD) is a distinct pattern of rapid tumor progression observed in patients with cancer who are undergoing immune checkpoint inhibitor therapy. Despite the growing evidence, a universal definition of HPD remains to be established, and incidence rates vary based on the defining criteria. Therefore, a refinement of currently existing criteria is warranted to better characterize this phenomenon and evaluate its incidence.MethodsTwo independent investigators performed a systematic literature search in EMBASE and MEDLINE using keywords selected in Park et al.1: ch

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Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Imad Abdelhamid EL HACI, Wissame MAZARI, and Fawzia ATIK-BEKKARA. "Effect of Ammodaucus leucotrichus Coss. & Dur. Essential Oil on the Viability of Erythrocytes and its Antiradical Activity Assessment." Journal of Natural Product Research and Applications 1, no. 02 (2021): 45–53. http://dx.doi.org/10.46325/jnpra.v1i02.14.

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Plants for medicinal purposes are considered as the main source of health care for the majority of the world population. In order to promote medicinal plants in Algeria, the present work aimed to assess the physico-chemical characterization, hemolytic, and antioxidant activities of Ammodaucus leucotrichus essential oil of an endemic plant from south-west of Algeria. The plant was harvested from the region of Bechar (south-west of Algeria). The oil was obtained by hydrodistillation method using Clevenger apparatus. The antioxidant activity of the oil was carried out using DPPH scavenging assay,

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Bashonga, Bishobibiri Alexis, Sande Eric, Ntakimazi Gaspard, and Kahindo Charles. "Bird Ecology in the Ruzizi Delta, Northern End of Lake Tanganyika in Burundi and in the Democratic Republic of Congo." Biolife 11, no. 1 (2023): 12–20. https://doi.org/10.5281/zenodo.7686228.

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<strong>Abstract</strong> Bird ecology in the Ruzizi Delta was investigated during the months of April, July and October 2019-2021. Three species of water birds were the most prominent, the Cattle Egret (Ardeidae), Bubulcus ibis (Linnaeus, 1758) «Héron garde boeufs», the Black Crake (Rallidae) Amaurornis flavirostris (Swainson, 1837) «Râle à bec jaune» and the Africana Jacana (Jacanidae) Actophilornis africanus (Gmelin, 1789) «Jacana a poitrine dorée». The objective pursued by the research is the sustainable conservation of birds b

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Sun, Aijun, Xueting Jin, Keqiang Wang, Yunzeng Zou, and Junbo Ge. "Abstract P298: Probucol Inhibits Oxidized Low-Density Lipoprotein--Induced Immune Maturation of Dendritic Cells via Heme Oxygenase 1." Circulation Research 109, suppl_1 (2011). http://dx.doi.org/10.1161/res.109.suppl_1.ap298.

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The anti-atherosclerotic mechanism of Probucol remains to be elucidated. Studies confirmed the key role of Dendritic Cells (DCs) and cytoprotective role of heme oxygenase 1(HO1) in the development of atherosclerosis. Here, we tested the hypothesis that probucol exerts is anti-atherosclerotic effect by inhibiting maturation of DCs via HO1. [Method]Immature DCs were derived from purified human monocytes; HO1 siRNA, probucol ,ox-LDL or LDL was added to different groups of medium. The maturation markers of DCs were analyzed by Flow cytometric analysis, including CD1a, CD40, CD86, HLA-DR, endocytos

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Chai, Grace, Jing Xu, Sonal Goyal, et al. "Trends in Incident Prescriptions for Behavioral Health Medications in the US, 2018-2022." JAMA Psychiatry, January 10, 2024. http://dx.doi.org/10.1001/jamapsychiatry.2023.5045.

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ImportanceThe COVID-19 pandemic reportedly increased behavioral health needs and impacted treatment access.ObjectiveTo assess changes in incident prescriptions dispensed for medications commonly used to treat depression, anxiety, attention-deficit/hyperactivity disorder (ADHD), and opioid use disorder (OUD), before and during the COVID-19 pandemic.Design, Setting, and ParticipantsThis was a cross-sectional study using comprehensive, population-level, nationally projected data from IQVIA National Prescription Audit on incident prescriptions (prescriptions dispensed to patients with no prior dis

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Dionne, Elyssa, Halbert Bai, Lucas Collins, et al. "Gender Differences in Iliofemoral Vein Stenting for Chronic Venous Insufficiency." Vascular and Endovascular Surgery, January 23, 2023, 153857442311543. http://dx.doi.org/10.1177/15385744231154330.

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Introduction Little is known about gender’s role in chronic venous insufficiency (CVI). The aim of this study was to evaluate the impact of gender on outcomes of iliac vein stenting(IVS) for CVI. Methods 866 patients who underwent vein stenting for CVI at one institution from August 2011 to June 2021 were analyzed via retrospective review. Patients were followed up to 5 years after initial stent placement. Presenting symptoms were quantified using Venous Clinical Severity Score(VCSS), Clinical Assessment Score(CAS), and Clinical, Etiology, Anatomy, and Pathophysiology (CEAP) class. Reoperation

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Buonfrate, D., C. Piubelli, F. Gobbi, et al. "Antibody response induced by the BNT162b2 mRNA COVID-19 vaccine in a cohort of health-care workers, with or without prior SARS-CoV-2 infection: a prospective study." Clinical Microbiology and Infection, February 23, 2022. https://doi.org/10.5281/zenodo.6243253.

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Objectives To assess the antibody response to BNT162b2 mRNA COVID-19 vaccine in a cohort of health-care workers (HCW), comparing individuals with previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and SARS-CoV-2-naive individuals. Methods HCW were tested at T0 (day of first dose), T1 (day of second dose) and T2 (2–3 weeks after second dose) for IgG anti-nucleocapsid protein, IgM anti-spike protein and IgG anti-receptor binding domain (IgG-RBD-S). The antibody response was compared between four main groups: group A, individuals with previous infection and

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Meyer, Jeremy, Jan Wijsman, Rogier Crolla, and George van der Schelling. "Implementation of totally robotic right hemicolectomy: lessons learned from a prospective cohort." Journal of Robotic Surgery, June 21, 2023. http://dx.doi.org/10.1007/s11701-023-01646-3.

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AbstractRobotics facilitates the realization of intra-corporeal anastomosis during right hemicolectomy and allows extracting the operative specimen through a C-section, offering potential benefits in terms of post-operative recovery and incidence of incisional hernia. Therefore, we progressively implemented robotic right hemicolectomy (robRHC) in our centre, and would like to report our initial experience with the technique. Consecutive patients who underwent robRHC within a single centre were prospectively included. Variables related to patients’ demographics, surgical procedures, post-operat

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Mondaini, N. "(034) Two Thousand Two Hundred Patients Treated with Collagenase Clostridium Histolitycum Collagenase in a Single Centre." Journal of Sexual Medicine 21, Supplement_2 (2024). http://dx.doi.org/10.1093/jsxmed/qdae002.034.

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Abstract Introduction Peyronie's disease (PD) is a common condition which results in penile curvature making sexual intercourse difficult or impossible. Collagenase clostridium histolyticum (CCH) is the first licensed drug for the treatment of PD and is indicated in patients with palpable plaque and curvature deformity of at least 30° of curvature. Objective To evaluate the results of a group composed of 2200 patients treated with clostridium histolyticum collagenase from December 2016 to March 2023, in a single European center. Methods We proceeded to review the database of 2200 patients diag

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Nam, Karam, Hye-Bin Kim, Young-Lan Kwak, et al. "Effect of changes in inspired oxygen fraction on oxygen delivery during cardiac surgery: a substudy of the CARROT trial." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-021-97555-2.

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AbstractWhen hemoglobin (Hb) is fully saturated with oxygen, the additional gain in oxygen delivery (DO2) achieved by increasing the fraction of inspired oxygen (FiO2) is often considered clinically insignificant. In this study, we evaluated the change in DO2, interrogated by mixed venous oxygen saturation (SvO2), in response to a change in FiO2 of 0.5 during cardiac surgery. When patients were hemodynamically stable, FiO2 was alternated between 0.5 and 1.0 in on-pump cardiac surgery patients (pilot study), and between 0.3 and 0.8 in off-pump coronary artery bypass grafting patients (substudy

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Shi, Chuang, Shiwei Guo, Lei Fan, et al. "GSTAR: an innovative software platform for processing space geodetic data at the observation level." Satellite Navigation 4, no. 1 (2023). http://dx.doi.org/10.1186/s43020-023-00109-2.

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AbstractTo meet the demands for the data combination with multiple space geodetic techniques at the observation level, we developed a new software platform with high extensibility and computation efficiency, named space Geodetic SpatioTemporal data Analysis and Research software (GSTAR). Most of the modules in the GSTAR are coded in C++ with object-oriented programming. The layered modular theory is adopted for the design of the software, and the antenna-based data architecture is proposed for users to construct personalized geodetic application scenarios easily. The initial performance of the

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Daliri, Mahla, Farideh Khosravi, Mohammad-T. Shakeri, Mohammad H. Ebrahimzadeh, and Ali Moradi. "Pairwise association of upper extremity musculoskeletal conditions: large population investigation from PERSIAN cohort study." Journal of Orthopaedic Surgery and Research 18, no. 1 (2023). http://dx.doi.org/10.1186/s13018-023-04108-6.

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Abstract Background People with one area of upper extremity musculoskeletal conditions (UEMSCs) may have other. We aim to determine how frequent is the ipsilateral coexistence of common UEMSCs apparent on interview and examination. Methods This is a large population cross-sectional study conducted as part of the PERSIAN cohort study int Mashhad University of Medical Sciences (MUMS). The study aimed to evaluate individuals for symptoms and signs of the following conditions: carpal tunnel syndrome (CTS), lateral epicondylitis (LE), trapeziometacarpal osteoarthritis (TMC OA), DeQuervain’s tendino

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Yazdi, Allen A., Alexander C. Weissman, Kyle R. Wagner, et al. "Sex-Based Differences in Clinically Significant Outcome Achievement Following Primary Osteochondral Allograft Transplantation of the Knee at a Minimum 5-Year Follow-up." American Journal of Sports Medicine, May 12, 2025. https://doi.org/10.1177/03635465251338219.

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Background: Primary osteochondral allograft transplantation (OCA) of the knee has been shown to improve patient-reported outcome measure (PROM) scores at various follow-up time points. However, studies analyzing the effects of patient sex on primary OCA outcomes remain limited and show conflicting results. Purpose: To compare PROM scores and clinically significant outcome (CSO) achievement rates at a minimum 5-year follow-up between male and female patients who underwent primary OCA of the knee. Study Design: Cohort study; Level of evidence, 3. Methods: A prospectively collected database was q

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Ruissen, Merel M., José D. Torres-Peña, Bas S. Uitbeijerse, et al. "Clinical impact of an integrated e-health system for diabetes self-management support and shared decision making (POWER2DM): a randomised controlled trial." Diabetologia, September 29, 2023. http://dx.doi.org/10.1007/s00125-023-06006-2.

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Abstract Aims/hypothesis There is a lack of e-health systems that integrate the complex variety of aspects relevant for diabetes self-management. We developed and field-tested an e-health system (POWER2DM) that integrates medical, psychological and behavioural aspects and connected wearables to support patients and healthcare professionals in shared decision making and diabetes self-management. Methods Participants with type 1 or type 2 diabetes (aged >18 years) from hospital outpatient diabetes clinics in the Netherlands and Spain were randomised using randomisation software to POWER2DM or

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van Dam, Paulien H., Wilco P. Achterberg, Bettina S. Husebo, and Monique A. A. Caljouw. "Does paracetamol improve quality of life, discomfort, pain and neuropsychiatric symptoms in persons with advanced dementia living in long-term care facilities? A randomised double-blind placebo-controlled crossover (Q-PID) trial." BMC Medicine 18, no. 1 (2020). http://dx.doi.org/10.1186/s12916-020-01858-6.

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Abstract Background The objectives of this study are to determine the effects of regularly scheduled administration of paracetamol (acetaminophen) on quality of life (QoL), discomfort, pain and neuropsychiatric symptoms of persons with dementia living in long-term care facilities (LTCFs). Methods A multicentre randomised double-blind placebo-controlled crossover trial for 13 weeks (January 2018 to June 2019) in 17 LTCFs across the west of the Netherlands. Inclusion criteria were age ≥ 65 years, (advanced) dementia and a moderate to low QoL, independent of the presence of pain (QUALIDEM ≤ 70).

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Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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Klein-Gordon, Jeannie M., Ross Joaquin Hatlen, and Timothy D. Miles. "First report of stem blight caused by Diaporthe eres on highbush blueberry (Vaccinium corymbosum) in Michigan." Plant Disease, April 20, 2023. http://dx.doi.org/10.1094/pdis-03-23-0463-pdn.

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The U.S. is the world’s leading producer of highbush blueberries (Vaccinium corymbosum L.), and Michigan is ranked in the top five production states (USDA NASS, 2022). In June and July of 2021, 268 blueberry stem blight samples were collected for a pathogen survey across 22 total fields in Van Buren and Ottawa counties in Michigan. Current season stems with symptoms of necrosis and wilting were collected. Stems were cut just below the necrotic area and cross-sections (2-3 mm long) were surface disinfested in 10% bleach for 1 min, rinsed twice in sterile distilled water, and dried on sterile pa

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Harris, Elizabeth. "Minimum volume covering ellipsoids." ANZIAM Journal 64 (May 4, 2024). http://dx.doi.org/10.21914/anziamj.v64.17956.

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We present a new initialisation of an adaptive batch strategy to compute the ε-approximate minimum volume covering ellipsoid (MVCE) for a set of n points. We focus on moderately sized datasets (up to dimension d = 100 and n = 1 000 000). The adaptive batch strategy works in an optimisation-deletion-adaptation cycle: we solve the MVCE problem using a smaller number of points, we delete points from consideration that are guaranteed to not lie on the boundary of the MVCE, and then carefully select a new batch of points. We propose a new initialisation, which involves selecting the points correspo

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Colaneri, M., G. Montrucchio, G. Scaglione, et al. "P01. The IMPACT-VAP study: incidence and mortality of ventilator-associated pneumonia in critically ill patients: results from the PROSAFE project." JAC-Antimicrobial Resistance 7, Supplement_2 (2025). https://doi.org/10.1093/jacamr/dlaf046.001.

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Abstract Background Despite preventive measures, ventilator-associated pneumonia (VAP) persists as the most frequent healthcare-associated infection in intensive care units (ICUs),1 with high incidence and mortality rates.2,3 Here, we wanted to study the incidence of VAP in 192 Italian ICUs in the last decade. Secondly, we wanted to describe the clinical and microbiological characteristics. Finally, we wanted to assess the variables associated with their intra-ICU mortality. Methods In this multicentric observational study, data from 192 Italian ICUs were retrieved from the PROSAFE project, a

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