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Journal articles on the topic '796.386:378 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Ditzel, Evert J., K. David Griths, and Glen B. Robertson. "Crystal Structure of mer-(PMe3)-trans(PEt3)(PPri3)H-trans-Cl2Ir III at 146 K." Australian Journal of Chemistry 50, no. 1 (1997): 75. http://dx.doi.org/10.1071/c96171.

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The structure of the novel mixed-phosphine complex mer(PMe3)-trans(PEt3)(PPri3)H-trans-Cl2IrIII has been determined by single-crystal X-ray diffraction analysis at 146±3 K. Crystals are monoclinic, space group P 21/c, with a 7·414(4), b 15·073(3), c 9·796(2) Å, β 97·46(1) and Z 4. Structure refinement by constrained (2xC-C distances) full-matrix least-squares analysis (2378 unique reflections, 217 parameters) converged with R 0·049 and ωR 0·055. The PPri3 ligand is face-to-face configured with the unique Pri group eclipsing the hydride ligand. The PEt3 ligand is asymmetrically configured with

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Smith, Graham, Catherine E. Pascoe, Colin H. L. Kennard, and Karl A. Byriel. "Molecular Adducts of 2,6-Diaminopyridine with Nitro-Substituted Aromatic Carboxylic Acids and the Crystal Structure of the 1 : 1 Adduct of 2,6-Diaminopyridine with 2-Nitrobenzoic Acid." Australian Journal of Chemistry 52, no. 1 (1999): 71. http://dx.doi.org/10.1071/c98140.

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The 1 : 1 adducts of 2,6-diaminopyridine (2,6-dap) with a series of nitro-substituted aromatic carboxylic acids have been prepared and the crystal structure of one of these, with 2-nitrobenzoic acid (2-nba), [(2,6-dap)+ (2-nba)-] has been determined by X-ray crystallography and refined to a residual R 0·034 for 655 observed reflections. Crystals are monoclinic, space group P 21/c, with four molecules in a cell of dimensions a 7·376(2), b 22·837(3), c 7·716(2) Å, β 90·01(2)°. The structure involves proton transfer with the resulting pyridinium proton and an amine proton combining with the carbo

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Latagliata, R., M. Breccia, P. Fazi, et al. "Long-Term Results of the GIMEMA LAP AIDA 0493 Amended Protocol in Elderly Patients with Acute Promyelocytic Leukemia (APL)." Blood 106, no. 11 (2005): 885. http://dx.doi.org/10.1182/blood.v106.11.885.885.

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Abstract In order to reduce toxicity in elderly patients with newly diagnosed APL, since 3/1997 the Italian cooperative group GIMEMA evaluated an amended AIDA protocol for patients aged &gt; 60 years, consisting of the same induction with ATRA and Idarubicin but only 1st consolidation course (Idarubicin + Cytarabine), followed by 2 years maintenance with ATRA alone. Up to now, 56 patients (25 males and 31 females, median age 66.2 years, 46 with PS 0-1 and 10 with PS 2) are fully evaluable. At onset, according to GIMEMA-PETHEMA risk score, 18 were low-risk(32.5%), 31 intermediate risk (55%)

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Vrancianu, C., I. Conea, A. Boca, et al. "FRI0551 PERFORMANCE OF THE 2019 AMERICAN COLLEGE OF RHEUMATOLOGY/EUROPEAN LEAGUE AGAINST RHEUMATISM SYSTEMIC LUPUS ERYTHEMATOSUS CLASSIFICATION CRITERIA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 877.2–877. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3786.

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Background:Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease, with increased morbidity and mortality, often diagnosed in advanced stages. The recently published 2019 American College Of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for SLE are weighted, hierarchically clustered criteria developed to increase reliability and the identification of early SLE.Objectives:To compare the sensitivity and specificity of the 2019 ACR/EULAR criteria with the 2012 SLICC criteria in a large single-centre cohort of patients with SLE, diagnosed acco

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Wood, Henry, Lauren Jamieson, Charles Manogaran, et al. "Correlation between the Integrated MDS Flow Cytometry Score and Genomic Abnormalities - a Single Centre Analysis from King's College Hospital." Blood 144, Supplement 1 (2024): 6751. https://doi.org/10.1182/blood-2024-211268.

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Myelodysplastic syndromes (MDS) are diagnosed based on peripheral cytopenias, morphological dysplasia and recurrent genomic abnormalities. Gene variants are found in approximately 90% of cases and cytogenetic abnormalities in 50% (Arber et al, 2022). Genomic abnormalities are key to diagnosis and prognosis (Bernard et al, 2022). The European Leukemia Net international MDS flow cytometry working group has recommended an integrated flow cytometry score (iFS) to support diagnosis of MDS (Oelshlaegel et al 2021; van de Loosdrecht et al, 2021). The score identifies three categories based on the num

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Kwon, Taesung, Stacy Kenyon, Kimberly Kilheeney, Stanley Martin, and Mark Shelly. "Prevalence of SARS-CoV-2 Antibody in Healthcare Workers in Central Pennsylvania." Antimicrobial Stewardship & Healthcare Epidemiology 1, S1 (2021): s49. http://dx.doi.org/10.1017/ash.2021.93.

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Background: Determining the incidence of SARS-CoV-2 in healthcare workers (HCW) is important in assessing the safety of the work environment. Though of limited use in acute illness, serologic testing can detect some infections that occur undetected. We compared the prevalence of antibodies to SARS-CoV-2 to a place of work, exposure by role and department, and use of various prevention methods. Methods: Healthcare workers (HCWs) working in Geisinger Health System were offered voluntary serology through Employee Health. Before they had blood taken, they completed a brief questionnaire. Testing w

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Subbiah, Ishwaria Mohan, Loretta A. Williams, Angela Peek, et al. "Real-world patient-reported and clinical outcomes of BNT162b2 mRNA COVID-19 vaccine in patients with cancer." Journal of Clinical Oncology 39, no. 15_suppl (2021): 6510. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.6510.

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6510 Background: Most COVID-19 (C19) vaccine trials excluded patients with active cancer. Here, we report our real-world patient-reported and clinical outcomes of BNT162b2 mRNA C19 vaccine in patients with cancer. Methods: Our institutional Data-Driven Determinants for COVID-19 Oncology Discovery Effort (D3CODE) follows a longitudinal observational cohort of pts w cancer getting C19 vaccine. Pts complete a validated PRO tool, MD Anderson Symptom Inventory (MDASI, 13 core, 6 interference plus 17 items of symptoms from prior vaccine trials) pre-dose 1, then daily x 6d, then weekly, then on day o

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Jaenudin, M., and Ali Hamdan. "Penilaian Dampak Zakat, Infak, Sedekah Terhadap Kemiskinan Spiritual Dan Material Penerima Manfaat Laznas LMI: Pendekatan CIBEST." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 3 (2022): 362–78. http://dx.doi.org/10.20473/vol9iss20223pp362-378.

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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikat

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Jaenudin, M., and Ali Hamdan. "Penilaian Dampak Zakat, Infak, Sedekah Terhadap Kemiskinan Spiritual Dan Material Penerima Manfaat Laznas LMI: Pendekatan CIBEST." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 3 (2022): 362–78. http://dx.doi.org/10.20473/vol9iss20223pp362-378.

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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikat

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Lazow, Margot, Andrew Trout, Christine Fuller, et al. "BIOM-42. IMMUNOHISTOCHEMICAL ASSESSMENT OF MEMBRANOUS SOMATOSTATIN TYPE 2A RECEPTOR (SST2A) EXPRESSION ACROSS HIGH-RISK PEDIATRIC CENTRAL NERVOUS SYSTEM (CNS) TUMORS." Neuro-Oncology 23, Supplement_6 (2021): vi20. http://dx.doi.org/10.1093/neuonc/noab196.073.

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Abstract INTRODUCTION 77Lu-DOTATATE, a radionuclide therapy which binds SST2A, has demonstrated efficacy in neuroendocrine tumors and evidence of CNS penetration, supporting potential expansion within pediatric neuro-oncology. Understanding the prevalence of SST2A expression across pediatric CNS tumors is essential to identify patients who may benefit from somatostatin receptor-targeted therapy and to further elucidate the oncogenic role of SST2A. METHODS SST2A immunohistochemistry (IHC) was performed on tumor specimens and interpreted by two experienced pathologists (blinded), utilizing semi-

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Wang, A., Y. Ding, and H. Cao. "DOP026 Porphyromonas gingivalis secreted htpG disrupts TLR4/ PAPSS2-mediated mucin sulfation and aggravates ulcerative colitis." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i132. https://doi.org/10.1093/ecco-jcc/jjae190.0065.

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Abstract Background The role of the oral microbiota in the development of IBD and its association with disease severity has been established. However, the specific impact and mechanism of Porphyromonas gingivalis (P.g), a major pathogenic bacteria in the oral cavity, in exacerbating colitis remain unclear. Our objective is to investigate how P.g exacerbates ulcerative colitis. Methods Fecal samples were collected from patients with active ulcerative colitis and compared to those from healthy controls to assess the abundance of P.g. The impact of P.g on colitis and the colonic mucosal barrier w

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De Agustin, J. J., G. Añez, D. Reina-Sanz, et al. "AB1116 APREMILAST IN PSORIATIC ARTHRITIS. ULTRASOUND ANALYSIS (JOINT-ENTHESES-UNGUEAL INDEX) OF THE EFFICACY AND VARIABLES CORRELATION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1787–88. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1397.

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BackgroundWe conducted a study using ultrasonography (US) to evidence inflammatory changes (joint-enthesis-ungueal) in active PsA (aPsA) patients who started Apremilast (A) in clinical practice.ObjectivesObtain a 20, 50, 70 % reduction in the US index (UIC) at 12 months, and study correlation between variables.MethodsPhase IV, multicenter, prospective and open-label clinical trialconductedin 9 centresfrom 2018 to 2021. All patients signed the informed consent. Approval by the ethical committee was obtained, code PSA-PI-006421. PsA patients (≥ 2 swollen joints), ≥ 2 joint US synovitis and ≥ 1 U

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Chen, Jennifer Hechao, Kerollos Wanis, Mahdia Rahman, et al. "Implications for sentinel lymph node biopsy (SLNB) omission in patients with early-stage node-negative HR+/HER2- breast cancer undergoing mastectomy." Journal of Clinical Oncology 43, no. 16_suppl (2025): 580. https://doi.org/10.1200/jco.2025.43.16_suppl.580.

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580 Background: The SOUND and INSEMA trials demonstrated non-inferiority of SLNB omission in HR+/HER2- early-stage breast cancer (BC) patients with negative axillary ultrasound (AUS) undergoing breast conserving therapy (BCT). However, it remains unclear if this approach may be applied to patients receiving mastectomy. We evaluated outcomes in a similar patient population receiving BCT versus mastectomy. Methods: Using an institutional database (2010-2023), we identified patients with cT1N0M0 HR+/HER2- unifocal invasive ductal carcinoma with negative AUS who underwent upfront BCT (breast conse

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Regierer, A., A. Weiß, M. Bohl-Buehler, et al. "OP0225 DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 135.2–136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2130.

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Background:Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting the musculoskeletal system as well as skin and nails. The prevalence of depression in psoriasis and PsA is high and ranges from 7-40% [1]. Persistent depressive mood may influence disease activity outcome in PsA, especially patient-reported outcomes.Objectives:To assess the correlation of depressive symptoms with PsA-specific outcome parameters.Methods:RABBIT-SpA is a prospective longitudinal cohort study including PsA patients enrolled at start of a new conventional treatment or b/tsDMARD treatment. In regularly

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Mashayekhi, Mona, Hui Nian, Sara E. Howard, et al. "LBSUN306 Effects Of Glp-1 Receptor Agonism, Dpp4 Inhibition, And Hypocaloric Diet On Metabolic Parameters In Obese Pre-diabetic Individuals: A Randomized-controlled Trial." Journal of the Endocrine Society 6, Supplement_1 (2022): A292—A293. http://dx.doi.org/10.1210/jendso/bvac150.603.

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Abstract Background GLP-1 receptor (GLP1R) agonists reduce glucose, weight and cardiovascular risk. Understanding the weight loss-dependent mechanisms of these benefits will inform treatment and drug development. This study compared metabolic responses among GLP1R agonist (liraglutide), DPP4 inhibitor (sitagliptin), and hypocaloric diet treatments. Methods We randomized 88 obese, pre-diabetic individuals in a 2: 1: 1 ratio to liraglutide, sitagliptin, or diet for 14 weeks. Treatment was double-blinded and placebo-controlled for drug. Individuals completed a mixed meal at baseline, 2 and 14 wee

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Kretzer, Ryan M., Christopher Chaput, Daniel M. Sciubba, et al. "A computed tomography–based feasibility study of translaminar screw fixation in the upper thoracic spine." Journal of Neurosurgery: Spine 12, no. 3 (2010): 286–92. http://dx.doi.org/10.3171/2009.10.spine09546.

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Object Translaminar screws (TLSs) offer an alternative to pedicle screw (PS) fixation in the upper thoracic spine. Although cadaveric studies have described the anatomy of the laminae and pedicles at T1–2, CT imaging is the modality of choice for presurgical planning. In this study, the goal was to determine the diameter, maximal screw length, and optimal screw trajectory for TLS placement at T1–2, and to compare this information to PS placement in the upper thoracic spine as determined by CT evaluation. Methods One hundred patients (50 men and 50 women), whose average age was 41.7 ± 19.6 year

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Cipolletta, E., A. DI Matteo, E. Filippucci, and W. Grassi. "THU0420 ULTRASOUND SHOWS GREAT ACCURACY FOR THE DIAGNOSIS OF CRYSTAL ARTHRITIS IN PATIENTS WITH RECENT-ONSET SYNOVITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 448.1–448. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1100.

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Background:The value of ultrasound (US) in the diagnosis of crystal arthropathy, such as gout or calcium pyrophosphate deposition disease (CPPD), in patients with recent onset synovitis has been evaluated only by a few studies.Objectives:To investigate, in patients with acute arthritis, the accuracy of US for the diagnosis of crystal arthropathy.Methods:Consecutive patients with recent onset (<6 weeks) acute arthritis were enrolled. The US examinations were performed a rheumatologist blinded to clinical data. Calcium pyrophosphate and monosodium urate crystal deposits were identified in the

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Sagatys, Elizabeth, Lynn Moscinski, Sophie Dessureault, Eduardo Sotomayor, and Hernani Cualing. "Analysis of T-Cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 1580. http://dx.doi.org/10.1182/blood.v110.11.1580.1580.

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Abstract Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell NHL characterized by a high relapse rate. Novel treatments capable of providing and/or sustaining more durable responses in MCL patients are clearly needed. Manipulation of the immune system to unleash its protective effect might induce durable responses in MCL. To effectively harness the immune system against MCL, it is important to understand how T-cells interact with malignant B-cells that reside where immune responses are normally initiated. In the present study, we evaluated the number and phenotype of T-cells prese

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Abreu, Milena Reis, Larissa Paiva, Tamires Costa Mendes, et al. "Risk Factors for Surgical Site Infection After Orthopedic Trauma Surgery: A Two-Year Prospective Multicenter Analysis." Infection Control & Hospital Epidemiology 41, S1 (2020): s377—s378. http://dx.doi.org/10.1017/ice.2020.1010.

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Background: Trauma is defined by the NHSN as “blunt or penetrating traumatic injury.” Therefore, if the surgery was performed because of a recent fall, for example, then it is a trauma surgery. Here, we investigated which preoperative and operative parameters are associated with surgical site infection (SSI) after orthopedic trauma surgery. Objective: We aimed to answer 3 main questions: What is the risk of wound infection for patients undergoing trauma surgery? What are the main etiologic agents of SSI after trauma surgery? And what are the risk factors associated with SSI after trauma surger

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Latagliata, R., M. Breccia, P. Fazi, et al. "Therapy-Related Myelodysplastic Syndrome (sMDS) /Acute Myelogenous Leukemia (sAML) in Acute Promyelocytic Leukemia (APL) Patients with Long-Lasting Molecular Remission: The GIMEMA Experience." Blood 106, no. 11 (2005): 884. http://dx.doi.org/10.1182/blood.v106.11.884.884.

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Abstract The occurrence of a sMDS in patients potentially cured from a previous APL has been recently reported. To evaluate the real incidence and the clinical characteristics of sMDS/sAML post APL, the follow-up of 336 patients with newly diagnosed APL enrolled by 22 GIMEMA Centers in the LAP AIDA 0493 protocol has been revised. After the induction, 314 patients (93.4%) achieved complete remission (CR): of them, 225 (71.6%) are still alive in 1st CR, 12 (3.8%) died in CR and 71 (22.7%) relapsed. The remaining 6 patients (1.9%) developed a sMDS while in 1st morphological CR, after a median tim

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Chamseddine, Sarah, Haniah A. Zaheer, John V. Williams, Judith M. Martin, Anne-Marie Rick, and Hui Liu. "1328. Risk Factors for Severe Influenza Outcomes Among Infants Born Between 2011 and 2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S752. http://dx.doi.org/10.1093/ofid/ofab466.1520.

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Abstract Background Influenza in infancy can cause significant morbidity and mortality. This study aimed to characterize influenza outcomes in infants &lt; ορ = 12 months and identify risk factors for severe infection. Methods A retrospective cohort of infants ≤ 12 months born between 2011-2019 who received longitudinal ambulatory and inpatient care within a multi-facility hospital system and had laboratory-confirmed influenza were included. Perinatal, medical and illness characteristics were described. Risk factors for severe influenza (hospitalization, intensive-care unit (ICU) admission

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Galindez, E., D. Prieto-Peña, J. L. Martín-Varillas, et al. "AB0768 TREATMENT WITH TOFACITINIB IN REFRACTORY PSORIATIC ARTHRITIS. MULTICENTER STUDY OF 87 PATIENTS IN CLINICAL PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1682.1–1682. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2903.

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Background:Tofacitinib (TOFA) is the first JAKi approved for psoriatic arthritis (PsA) in Europe (July 2018). TOFA has shown efficacy in refractory patients to anti-TNF in Randomized Clinical Trials (RCT) (Gladman D. NEJM 2017; 377: 1525-36).Objectives:To assess efficacy and safety of TOFA in clinical practice (CP). To compare the profile of CP with RCTMethods:Study of 87 patients of CP with PsA treated with TOFA; Results are expressed as percentage, mean±SD or median [IRQ].Results:87 patients (28♀/59♂), mean age of 52.8±11.4 years (Table 1). Pattern of joint involvement was: peripheral (n=60)

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Han, Jiuying, Neng Wan, Joshua J. Horns, and Marta L. McCrum. "Application of Community Detection Methods to Identify Emergency General Surgery–Specific Regional Networks." JAMA Network Open 7, no. 10 (2024): e2439509. http://dx.doi.org/10.1001/jamanetworkopen.2024.39509.

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ImportanceThere is growing interest in developing coordinated regional systems for nontraumatic surgical emergencies; however, our understanding of existing emergency general surgery (EGS) care communities is limited.ObjectiveTo apply network analysis methods to delineate EGS care regions and compare the performance of this method with the Dartmouth Health Referral Regions (HRRs).Design, Setting, and ParticipantsThis cross-sectional study was conducted using the 2019 California and New York state emergency department and inpatient databases. Eligible participants included all adult patients wi

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Diamanti-Kandarakis, Evanthia, Giovanna Spina, Chryssa Kouli, and Ilias Migdalis. "Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy." Journal of Clinical Endocrinology & Metabolism 86, no. 10 (2001): 4666–73. http://dx.doi.org/10.1210/jcem.86.10.7904.

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Women with polycystic ovary syndrome who present with hyperandrogenemia, hyperinsulinemia, and insulin resistance appear to be at high risk of cardiovascular disease. Elevated levels of endothelin-1, a marker of vasculopathy, have been reported in insulin-resistant subjects with endothelial dysfunction. Male gender also seems to be an aggravating factor for cardiovascular disease. In this study we investigated endothelin-1 levels in women with polycystic ovary syndrome, and we evaluated the effect of an insulin sensitizer, metformin, on endothelin-1 levels. Plasma endothelin-1 levels were meas

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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Viswabandya, Auro, P. V. Prashanthi, C. Nirmala Raju, et al. "Pharmacokinetic and Pharmacodynamic Evaluation of a Biosimilar Rituximab in Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) Treated with R-CHOP (Rituximab, Cyclophosphamide, Adriamycin, Vincristine, Prednisolone)." Blood 110, no. 11 (2007): 4491. http://dx.doi.org/10.1182/blood.v110.11.4491.4491.

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Abstract Addition of rituximab (375 mg/m2) to CHOP has been shown to improve survival in patients with DLBCL. However there is limited data on the pharmacokinetics (PK) and pharmacodynamics (PD) of this drug in this condition. We have evaluated the PK and PD of a biosimilar rituximab (Reditux®, Dr. Reddy’s Laboratories Ltd, Hyderabad, India) in 17 patients with newly diagnosed DLBCL treated at a single center with R-CHOP as part of a multi-center study undertaken to assess the safety and efficacy of this drug. R-CHOP (rituximab-375mg/m2; cyclophopsphamide-750mg/m2; adriamycin-50mg/m2; vincrist

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Kaufman, Adrienne, Marshall Mazepa, and Michael D. Evans. "Can We Improve on Prednisone and Rituximab for Immune TTP? an Analysis of Alternatives to the Standard of Care from the Ustma TTP Retrospective Registry." Blood 144, Supplement 1 (2024): 142. https://doi.org/10.1182/blood-2024-209162.

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Introduction: Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder caused by an autoantibody-mediated deficiency of ADAMTS13, for which the goal of treatment with immunosuppression is to induce long term remission. Currently, the standard of care (SOC), corticosteroids and rituximab (RTX), fails to induce long term remission in many patients. Therefore, we aimed to assess whether alternative regimens for treatment of iTTP episodes improved upon or were less efficacious in inducing relapse-free survival (RFS) compared to SOC, using data from the United

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Combe, B., Y. Tanaka, P. Emery, et al. "POS0679 CLINICAL OUTCOMES UP TO WEEK (W) 48 IN THE ONGOING FILGOTINIB (FIL) LONG-TERM EXTENSION (LTE) TRIAL OF RHEUMATOID ARTHRITIS (RA) PATIENTS (pts) WITH INADEQUATE RESPONSE (IR) TO METHOTREXATE (MTX) INITIALLY TREATED WITH FIL OR ADALIMUMAB (ADA) DURING THE PHASE 3 PARENT STUDY (PS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 615–16. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1641.

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BackgroundThe preferential Janus kinase-1 inhibitor FIL is approved for treatment of moderate to severe active RA in Europe and Japan.ObjectivesEfficacy and safety of FIL were assessed in pts with IR to MTX who completed a Phase 3 trial (NCT02889796)1 and enrolled in an LTE (NCT03025308).MethodsPts completing the PS1 on study drug were eligible to enter the LTE (data cutoff: June 1, 2020). Median exposure: 2.2 years (y). Efficacy data to W48 are reported for 4 treatment groups (all with background MTX): pts receiving FIL 200 mg (FIL200) or FIL 100 mg (FIL100) in the PS and continuing their dos

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Swaminathan, Mahesh, Kiyomi Morita, Yan Yuanqing, et al. "Clinical Heterogeneity of AML Is Associated with Mutational Heterogeneity." Blood 132, Supplement 1 (2018): 5240. http://dx.doi.org/10.1182/blood-2018-99-117287.

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Abstract BACKGROUND: AML is a group of clinically heterogeneous diseases. We hypothesized that heterogeneous presentation of AML is a reflection of equally heterogeneous genetic process during the leukemogenesis. METHODS: 536 AML patients (pts) bone marrow samples were analyzed by targeted capture exome sequencing of 295 genes. Extensive clinical-genotype correlation was performed using well annotated clinical data. RESULTS: The median age of the cohort was 62 years (IQR: 51-72) including 297 (55%) elderly (age ≥60), and 239 (45%) young (age <60) pts. Of the 536 pts, 308 (57%) pts had de no

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Kaufman, Jonathan L., Saad Z. Usmani, Jesús San-Miguel, et al. "Four-Year Follow-up of the Phase 3 Pollux Study of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Relapsed or Refractory Multiple Myeloma (RRMM)." Blood 134, Supplement_1 (2019): 1866. http://dx.doi.org/10.1182/blood-2019-123483.

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Introduction: Daratumumab, a human IgGκ monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action, is approved in combination with standard-of-care regimens for the treatment of newly diagnosed multiple myeloma (NDMM) and RRMM. When combined with standard of care regimens across four phase 3 studies, daratumumab demonstrated ≥44% reductions in the risk of progression or death, nearly doubled complete response (CR) or better rates, and tripled minimal residual disease (MRD)-negative rates at the 10-5 sensitivity threshold in pts with RRMM or NDMM (Palumb

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Ferreira, R. M., H. Ayres, M. L. Ferraz, et al. "266 OVUM PICKUP AND IN VITRO EMBRYO PRODUCTION DURING THE SUMMER: DIFFERENCES BETWEEN HOLSTEIN HEIFERS, HIGH-PRODUCING HOLSTEIN COWS IN PEAK LACTATION, AND REPEAT-BREEDER HOLSTEIN COWS." Reproduction, Fertility and Development 22, no. 1 (2010): 290. http://dx.doi.org/10.1071/rdv22n1ab266.

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The association of ovum pickup (OPU) and in vitro embryo production (IVP) has been widely used to improve bovine reproduction. However, previous reports have indicated the occurrence of low fertility associated with summer heat stress. In the present work, we hypothesized that different categories of Holstein cattle [heifers (H), high-producing cows in peak lactation (PL), and repeat-breeders (RB)] would respond differently to OPU and IVP during the summer, because of their different metabolisms. This experiment was conducted on 2 commercial dairy farms in southeast Brazil in summer 2009. Catt

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Amisha, Fnu, Ziad Abuhelwa, Wenyi Fan, et al. "Predictive Markers for Outcomes after Disease Progression Post BCMA-Directed CAR T-Cell Therapy in Patients with Relapsed or Refractory Multiple Myeloma." Blood 144, Supplement 1 (2024): 2004. https://doi.org/10.1182/blood-2024-211822.

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BACKGROUND Idecabtagene vicleucel (I) and Ciltacabtagene autoleucel (C) are two commercially available BCMA-directed CAR-T cell products initially FDA approved after &gt; 4 lines of therapy in patients with triple class exposed relapsed or refractory multiple myeloma patients (RRMM). Despite a high overall response rate, patients develop progressive disease. Little is known regarding factors associated with outcomes after progression post BCMA-directed CAR T-cell therapy and the optimal management strategy for post progression remains to be elusive. METHODS We conducted a single-center ret

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Baraliakos, X., E. Pournara, D. D. Gladman, P. J. Mease, S. Jahandideh, and L. Coates. "POS1110 PATIENT CLUSTERS IDENTIFIED BY MACHINE LEARNING: DATA FROM A POOLED ANALYSIS OF PHASE-3 TRIALS OF SECUKINUMAB IN PSORIATIC ARTHRITIS, ANKYLOSING SPONDYLITIS AND PSORIATIC ARTHRITIS WITH AXIAL MANIFESTATIONS." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 879.1–879. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2975.

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BackgroundUniversally acceptable criteria to define axial psoriatic arthritis (PsA) are lacking. Machine learning (ML) algorithms can detect patterns from large clinical datasets and identify clusters with potential therapeutic or prognostic significance in PsA patients (pts) with axial manifestations.[1]ObjectivesTo identify pt clusters based on baseline (BL) demographics and clinical indicators to support characterisation of the axial PsA phenotype within the spondyloarthritis (SpA) spectrum.MethodsPooled BL demographics and clinical data of secukinumab (SEC)-treated pts from 10 Phase-3 stud

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Pachai, C., S. Connolly, J. Landis, et al. "THU0095 IMPACT OF BASELINE EROSION SCORE ON RESPONSE TO TREATMENT AND FUTURE RADIOLOGICAL DAMAGE IN AVERT-2, A RANDOMISED PHASE IIIB STUDY OF ABATACEPT IN MTX-NAÏVE, ANTI-CITRULLINATED PROTEIN ANTIBODY–POSITIVE (ACPA+) PATIENTS WITH EARLY RA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 261.1–261. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1238.

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Background:Bone erosions are associated with poor prognosis in patients (pts) with RA. They can be associated with subclinical inflammation and independently predict future radiological damage.1The Phase IIIbAssessingVeryEarlyRATreatment (AVERT)-2 (NCT02504268) trial evaluated abatacept (ABA)+MTX in MTX-naïve, ACPA+ pts with early RA.2Objectives:To explore the impact of baseline (BL) X-ray erosion scores (ES) on clinical response and future radiological damage over 1 yr in different groups of pts from AVERT-2.Methods:BL and Wk 52 X-ray data were evaluated using Sharp/van der Heijde score. SDAI

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Peters, Dr, Peter Bader, Ulrike Pötschger, et al. "Similar Overall Survival and Event-Free Survival for Patients Under or over the Age of 14 Years, but More Chronic Graft Versus Host Disease and Non-Relapse Mortality in the “Older” Patients." Blood 142, Supplement 1 (2023): 3548. http://dx.doi.org/10.1182/blood-2023-185870.

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Purpose: In the prospective, randomized, multinational FORUM trial, total body irradiation and etoposide were statistically more effective than chemoconditioning (Peters et al, JCO 2021; FORUM study; EudraCT: 2012-003032-22; ClinicalTrials.gov: NCT01949129). The multivariate analysis in this cohort showed an inferior overall survival (OS) for patients (pts) over the age of 10 years, HR 1.8 (95% CI, p=0.048). To update these findings, we examine the impact of age at allogeneic hematopoietic stem cell transplantation (HSCT), we analyzed 791 FORUM pts who received TBI and etoposide as conditionin

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Ritchlin, C. T., P. J. Mease, W. H. Boehncke, et al. "AB0526 SUSTAINED GUSELKUMAB RESPONSE IN PATIENTS WITH ACTIVE PSORIATIC ARTHRITIS REGARDLESS OF BASELINE DEMOGRAPHIC AND DISEASE CHARACTERISTICS: POOLED RESULTS THROUGH WEEK 52 OF TWO PHASE 3, RANDOMIZED, PLACEBO-CONTROLLED STUDIES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1291–92. http://dx.doi.org/10.1136/annrheumdis-2021-eular.437.

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Background:In the Phase 3 DISCOVER-11 & DISCOVER-22 trials, guselkumab (GUS), a human monoclonal antibody targeting the IL-23p19-subunit, was effective in psoriatic arthritis (PsA) across joint & skin endpoints. At Week 24 (W24), GUS benefit was consistent regardless of baseline (BL) demographic & disease characteristics.3Objectives:We assessed whether GUS efficacy was sustained through W52 in pooled DISCOVER-1 & -2 patients (pts) across select BL subgroups.Methods:Adults with active PsA despite standard therapies were enrolled in DISCOVER-1 (swollen [SJC] ≥3 & tender joint

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Zabotti, A., M. M. Luchetti, C. Selmi, et al. "POS0233 DISEASE COURSE AND PREDICTORS FOR ACHIEVING 6-MONTH MINIMAL DISEASE ACTIVITY IN PATIENTS WITH EARLY PSORIATIC ARTHRITIS FROM THE ITALIAN PROSPECTIVE SIRENA STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 348–49. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1939.

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BackgroundData on Psoriatic Arthritis (PsA) patients naive to any Disease Modifying Anti-Rheumatic Drugs (DMARDs) are limited.ObjectivesTo describe the clinical course and predictors for achieving Minimal Disease Activity (MDA) in PsA patients starting DMARDs in a real-world setting.MethodsPsA patients were enrolled in SIRENA (Clinicaltrials.gov identifierNCT03131661), an Italian Registry of Spondyloarthritis (SpA) patients classified according to ASAS criteria and naive to any DMARDs for SpA [1]. Clinical data were collected at baseline and every 6 months up to the 24-month observation period

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Квітіньйо Макарена Мартінез, Соріано Федеріко Ґонзало, Яйченко Вірджинія, Стіб Бренда, and Барейро Хуан Пабло. "Predictors of Picture Naming and Picture Categorization in Spanish." East European Journal of Psycholinguistics 6, no. 1 (2019): 6–18. http://dx.doi.org/10.29038/eejpl.2019.6.1.cui.

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The aim of this paper was to identify which psycholinguistic variables are better predictors of performance for healthy participants in a picture naming task and in a picture categorization task. A correlation analysis and a Path analysis were carried out. The correlation analysis showed that naming accuracy and naming latency are significant and positively correlated with lexical frequency and conceptual familiarity variables, whereas they are negatively correlated with H index. Reaction times in the categorization task were negatively correlated with lexical frequency and conceptual familiar

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Hou, Jian, Weijun Fu, Soo-Mee Bang, et al. "Daratumumab, Bortezomib, Melphalan, and Prednisone Versus Bortezomib, Melphalan, and Prednisone in Transplant-Ineligible Patients with Newly Diagnosed Multiple Myeloma: Pooled Analysis of Octans and Alcyone." Blood 138, Supplement 1 (2021): 1661. http://dx.doi.org/10.1182/blood-2021-146974.

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Abstract Introduction: Daratumumab is a human IgGκ monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action. In the global phase 3 ALCYONE trial, the addition of daratumumab to bortezomib, melphalan, and prednisone (D-VMP) resulted in improved outcomes over bortezomib, melphalan, and prednisone (VMP) alone in transplant-ineligible patients (pts) with newly diagnosed multiple myeloma (NDMM). At a median follow-up of 16.5 months, the median progression-free survival (PFS) was not reached (NR) for the D-VMP group versus 18.1 months for the VMP group (haza

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Dimopoulos, Meletios A., Maria-Victoria Mateos, Michele Cavo, et al. "One-Year Update of a Phase 3 Randomized Study of Daratumumab Plus Bortezomib, Melphalan, and Prednisone (D-VMP) Versus Bortezomib, Melphalan, and Prednisone (VMP) in Patients (Pts) with Transplant-Ineligible Newly Diagnosed Multiple Myeloma (NDMM): Alcyone." Blood 132, Supplement 1 (2018): 156. http://dx.doi.org/10.1182/blood-2018-156.

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Abstract Introduction Daratumumab (DARA) is a human IgGκ anti-CD38 monoclonal antibody with a direct on-tumor and immunomodulatory mechanism of action. In combination with standard of care (SOC) regimens, DARA has consistently demonstrated a doubling of complete response (CR) rates, tripling of minimal residual disease (MRD)-negative rates, and reduction in the risk of progression or death by ≥50% vs SOC alone in relapsed/refractory MM and NDMM pts. In the prespecified interim analysis of ALCYONE, a phase 3 study of D-VMP versus VMP in transplant ineligible NDMM (Mateos MV, N Engl J Med 2018.

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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Hong, Seung Pyo, Min Jeong Kim, Allison Belette, Youjin Oh, Sukjoo Cho, and Young Kwang Chae. "238 Meta-analysis on the incidence of hyperprogressive disease during immune checkpoint inhibitor therapy." Journal for ImmunoTherapy of Cancer 9, Suppl 2 (2021): A254—A256. http://dx.doi.org/10.1136/jitc-2021-sitc2021.238.

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BackgroundHyperprogressive disease (HPD) is a distinct pattern of rapid tumor progression observed in patients with cancer who are undergoing immune checkpoint inhibitor therapy. Despite the growing evidence, a universal definition of HPD remains to be established, and incidence rates vary based on the defining criteria. Therefore, a refinement of currently existing criteria is warranted to better characterize this phenomenon and evaluate its incidence.MethodsTwo independent investigators performed a systematic literature search in EMBASE and MEDLINE using keywords selected in Park et al.1: ch

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Warmansyah, Jhoni, Restu Yuningsih, Evi Selva Nirwana, et al. "The Effect of Mathematics Learning Approaches and Self-Regulation to Recognize the Concept of Early Numbers Ability." JPUD - Jurnal Pendidikan Usia Dini 17, no. 1 (2023): 54–81. http://dx.doi.org/10.21009/jpud.171.05.

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The ability to recognize the concept of early numbers in early childhood is very important to develop so that children are ready to take part in learning mathematics at a higher level. This study aims to determine the effect of mathematics learning approaches and self-regulation to recognize the concept of early numbers ability in kindergarten. The study used an experimental method with a treatment design by level 2x2. The sample used was 32 children. Score data, ability to recognize number concepts, analyzed and interpreted. The results showed that: (1) The Realistic Mathematics Education app

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Warmansyah, Jhoni, Afriyane Ismandela, Dinda Fatma Nabila, et al. "Smartphone Addiction, Executive Function, and Mother-Child Relationships in Early Childhood Emotion Dysregulation." JPUD - Jurnal Pendidikan Usia Dini 17, no. 2 (2023): 241–66. http://dx.doi.org/10.21009/jpud.172.05.

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Early childhood emotional dysregulation is critical in recognizing and preventing psychological well-being disorders, laying the groundwork for developing healthy emotional behaviors early on. This study aims to determine the direct influence of smartphone addiction, executive function, and the mother-child relationship on emotional dysregulation in early childhood in West Sumatra. This research method is a quantitative survey. The data collection technique in this research uses a questionnaire design on 309 parents who were selected using a simple random sampling method. This data processing

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Facon, Thierry, Shaji K. Kumar, Torben Plesner, et al. "Phase 3 Randomized Study of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) in Patients with Newly Diagnosed Multiple Myeloma (NDMM) Ineligible for Transplant (MAIA)." Blood 132, Supplement 1 (2018): LBA—2—LBA—2. http://dx.doi.org/10.1182/blood-2018-120737.

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Abstract Introduction Lenalidomide-based therapies are a standard of care for patients with newly diagnosed, transplant-ineligible MM. Daratumumab (DARA) is a human, CD38-targeted, IgG1κ monoclonal antibody which has single-agent activity in heavily pretreated MM patients. As previously reported in 3 phase 3 studies, the addition of DARA to standards of care in both relapsed refractory (D-Rd, DARA plus bortezomib and dexamethasone [D-Vd]) or transplant-ineligible NDMM (DARA plus bortezomib, melphalan, and prednisone [D-VMP]) resulted in a ≥50% reduction in the risk of disease progression or de

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Orellana Hernández, Kenny Linette. "El liderazgo del director y el desempeño docente autopercibido en un grupo de colegios privados salvadoreños." RIEE | Revista Internacional de Estudios en Educación 19, no. 1 (2019): 47–63. http://dx.doi.org/10.37354/riee.2019.189.

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La investigación –cuantitativa, descriptiva, correlacional y transversal– pretendió conocer si las dimensiones del liderazgo directivo –transformacional, transaccional y laissez-faire– predicen significativamente el desempeño docente, de acuerdo con la percepción de 105 docentes de un grupo de nueve colegios privados salvadoreños, quienes respondieron (a) el Cuestionario Multifactorial (MQL), de 45 ítems, y (b) el Cuestionario de Autoevaluación Docente, para medir la variable desempeño docente, de 20 ítems. Se utilizó el análisis de regresión múltiple. De las tres dimensiones del liderazgo del

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Neto, Alfredo Alcure, Silvania Neris Nossa, Aridelmo Teixeira, and Nadia Cardoso Moreira. "Educação municipal e a escola em tempo integral (Municipal education and school in full time)." Revista Eletrônica de Educação 15 (December 22, 2021): e4099065. http://dx.doi.org/10.14244/198271994099.

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e4099065This research aimed to verify the association between I-Educ, an indicator that makes up one of the dimensions of IEGM, with indicators that accompany students' learning and full-time enrollment. The period of analysis adopted was 2015 and 2017 in the municipalities of the Brazilian states, totaling 7,852 observations. Methodologically, it was proposed a theoretical model in which I-Educ acts as a dependent variable, and the Prova Brasil, TRM, ETI and IRD as independent variables, we used statistical tests to verify empirically the studied relation, probit regression and marginal effec

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Padakanti, Anudeep, Vidya Sagar Dusi, Suresh V. S. Attili, Palanki Satya Dattatreya, and Rakesh Sharma. "Feasibility of half-dose dual-targeted therapy in advanced solid tumors with NGS-proven actionable targets: A comparative analysis with OMCT." Journal of Clinical Oncology 43, no. 16_suppl (2025). https://doi.org/10.1200/jco.2025.43.16_suppl.e14659.

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e14659 Background: Inspired by the efficacy of low-dose combination therapies in overcoming resistance in EGFR inhibitor-resistant NSCLC (Nature Communications), this study explores a similar strategy in advanced solid tumors. Standard-dose targeted therapies often face toxicity-related limitations in combinatory use. While metronomic chemotherapy (OMCT) reduces toxicity, it may not fully leverage molecular vulnerabilities .This feasibility study evaluates a novel approach using half-dose dual-targeted therapies, combining monoclonal antibodies (mAbs) or tyrosine kinase inhibitors (TKIs), to b

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