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Journal articles on the topic '796.4:378 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Ditzel, Evert J., K. David Griths, and Glen B. Robertson. "Crystal Structure of mer-(PMe3)-trans(PEt3)(PPri3)H-trans-Cl2Ir III at 146 K." Australian Journal of Chemistry 50, no. 1 (1997): 75. http://dx.doi.org/10.1071/c96171.

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The structure of the novel mixed-phosphine complex mer(PMe3)-trans(PEt3)(PPri3)H-trans-Cl2IrIII has been determined by single-crystal X-ray diffraction analysis at 146±3 K. Crystals are monoclinic, space group P 21/c, with a 7·414(4), b 15·073(3), c 9·796(2) Å, β 97·46(1) and Z 4. Structure refinement by constrained (2xC-C distances) full-matrix least-squares analysis (2378 unique reflections, 217 parameters) converged with R 0·049 and ωR 0·055. The PPri3 ligand is face-to-face configured with the unique Pri group eclipsing the hydride ligand. The PEt3 ligand is asymmetrically configured with

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Palomeque de la Cruz, Miguel Angel, Silvia del Carmen Ruiz Acosta, Rodimiro Ramos Reyes, Miguel Alberto Magaña Alejandro, and Adalberto Galindo Alcantara. "Modelación de cambios de coberturas y uso de suelo en Nacajuca, Tabasco." Revista Mexicana de Ciencias Agrícolas 12, no. 4 (2021): 655–69. http://dx.doi.org/10.29312/remexca.v12i4.2622.

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El crecimiento urbano de Nacajuca, Tabasco, ha transformado el sistema natural, siendo necesario conocer la actual configuración espacial de las coberturas naturales y los usos artificiales con la finalidad de proveer información de la dinámica espacial para el ordenamiento ecológico. El objetivo del estudio fue modelar los cambios de cobertura y uso del suelo (2000, 2008 y 2017), mediante un análisis multitemporal empleando el Land Change Modeler for ecological sustainability de IDRISI. Los resultados indican que en el periodo 2000-2008 se encontró la disminución de los humedales (1 796 ha) y

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Bowmaker, Graham A., Frances M. M. Hannaway, Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. IV Bismuth(III) Halide/N,N′-Bidentate Ligand (1 : 1) Systems." Australian Journal of Chemistry 51, no. 4 (1998): 325. http://dx.doi.org/10.1071/c97039.

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Room-temperature single-crystal X-ray studies are recorded for a number of adducts of BiX3 and N,N′-bidentate ligand (2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen)), devoid of coordinated solvent. BiBr3/bpy/MeCN (1 : 1 : 1) is triclinic P-1, a 12·129(2), b 9·955(4), c 7·748(1) Å, α 73·14(2), β 77·34(1), γ 69·79(2)°, Z = 2; conventional R on |F| was 0·036 for No 2252 independent ‘observed’ (I > 3σ(I)) reflections. The phen analogue is isomorphous, a 11·586(3), b 10·839(6), c 7·769(10) Å, α 73·70(7), β 76·67(7), γ 70·34(4)°, Z = 2, R 0·042 for No 800. BiI3/bpy (1 : 1) is triclinic, P-1,

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Bowmaker, Graham A., Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. I Large-Cation (2,2′-Bipyridinium and 1,10-Phenan- throlinium) Salts of Polyhalobismuthate(III) Ions." Australian Journal of Chemistry 51, no. 4 (1998): 293. http://dx.doi.org/10.1071/c97036.

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Syntheses and room-temperature single-crystal X-ray studies are recorded for a variety of salts of cations derived from protonated 2,2′-bipyridine and 1,10-phenanthroline (bpyH+ and phenH+) with polyhalobismuthate(III) anions. ‘[(phenH)(phenH2)(H2O)2] [BiCl6]’ is triclinic, P-1, a 9·791(1), b 9·338(3), c 8·311(3) Å, α 73·46(3), β 69·71(2), γ 86·36(2)°, Z = 1; conventional R on |F| was 0·027 for No 4852 independent ‘observed’ (I > 3σ(I)) reflections. [BiCl6]3- is closely octahedral, accompanied by an interesting protonation/hydrogen-bonding array among the other moieties. The latter comment

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Santos, Rafaela Magalhães dos, Rodrigo Máximo Sanchéz-Román, Hélio Grassi Filho, Vicente Mota da Silva, and Anderson de Jesus Pereira. "COEFICIENTE DE PRODUTIVIDADE – KY DO FEIJÃO CARIOCA (Phaseolus vulgaris L. TAA DAMA.) PARA O MUNICÍPIO DE BOTUCATU-SP." IRRIGA 27, no. 4 (2022): 785–94. http://dx.doi.org/10.15809/irriga.2022v27n4p785-794.

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COEFICIENTE DE PRODUTIVIDADE – KY DO FEIJÃO CARIOCA (Phaseolus vulgaris L. TAA DAMA.) PARA O MUNICÍPIO DE BOTUCATU-SP* RAFAELA MAGALHÃES DOS SANTOS1; RODRIGO MÁXIMO SÁNCHEZ ROMÁN2; HELIO GRASSI FILHO3; VICENTE MOTA DA SILVA4; ANDERSON DE JESUS PEREIRA5 * Esta nota científica é parte da dissertação intitulada: Resposta produtiva do feijão carioca (Phaseolus vulgaris L. TAA DAMA.) sob déficit hídrico em diferentes fases fenológicas. 1 Departamento de Ciência Florestal, Solos e Ambiente, Faculdade de Ciências Agronômicas, Universidade Estadual Paulista (UNESP), Avenida Universitária, nº 3780 – CE

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Latagliata, R., M. Breccia, P. Fazi, et al. "Long-Term Results of the GIMEMA LAP AIDA 0493 Amended Protocol in Elderly Patients with Acute Promyelocytic Leukemia (APL)." Blood 106, no. 11 (2005): 885. http://dx.doi.org/10.1182/blood.v106.11.885.885.

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Abstract In order to reduce toxicity in elderly patients with newly diagnosed APL, since 3/1997 the Italian cooperative group GIMEMA evaluated an amended AIDA protocol for patients aged &gt; 60 years, consisting of the same induction with ATRA and Idarubicin but only 1st consolidation course (Idarubicin + Cytarabine), followed by 2 years maintenance with ATRA alone. Up to now, 56 patients (25 males and 31 females, median age 66.2 years, 46 with PS 0-1 and 10 with PS 2) are fully evaluable. At onset, according to GIMEMA-PETHEMA risk score, 18 were low-risk(32.5%), 31 intermediate risk (55%)

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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KIM, JIN KYUNG, ELAINE M. D'SA, MARK A. HARRISON, JUDY A. HARRISON, and ELIZABETH L. ANDRESS. "Listeria monocytogenes Survival in Refrigerator Dill Pickles." Journal of Food Protection 68, no. 11 (2005): 2356–61. http://dx.doi.org/10.4315/0362-028x-68.11.2356.

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Listeria monocytogenes can survive and grow in refrigerated foods with pH values of approximately 4.0 to 5.0 and salt concentrations of 3 to 4%. Home-fermented refrigerator dill pickles fit this description. Contamination of this product with L. monocytogenes could cause serious problems because these items are not heated prior to consumption. L. monocytogenes survival and growth patterns were investigated in refrigerator dill pickles at 1.3, 3.8, and 7.6% salt concentrations. Pickling cucumbers were dipped into an inoculum of L. monocytogenes, brine mixtures were added, and cucumbers were hel

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Moltó, A., A. Ajrouche, D. Tran, et al. "POS0305 CONTINUING TNFI AFTER PREGNANCY DIAGNOSIS IN WOMEN WITH CHRONIC RHEUMATIC INFLAMMATORY DISEASES IS NOT ASSOCIATED WITH WORSE OBSTETRICAL OR INFECTIOUS OUTCOMES: THE RESULTS OF AN EMULATED TARGET TRIAL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 395.2–396. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3787.

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BackgroundContinuation of biologics during pregnancy in patients with chronic inflammatory diseases during pregnancy is still a difficult medical decision. Many women with chronic rheumatic inflammatory diseases (CRID) decide to stop tumor necrosis factor inhibitors (TNFi) treatment once pregnancy is confirmed to avoid potential adverse fetal events but taking the risk of inflammatory flare.ObjectivesTo compare in real life settings the pregnancy outcomes of two treatment strategies among women with CRID: to continue TNFi vs. stop TNFi upon pregnancy diagnosis.Methodsthe French nationwide heal

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von Pawel, Joachim, Joan H. Schiller, Frances A. Shepherd, et al. "Topotecan Versus Cyclophosphamide, Doxorubicin, and Vincristine for the Treatment of Recurrent Small-Cell Lung Cancer." Journal of Clinical Oncology 17, no. 2 (1999): 658. http://dx.doi.org/10.1200/jco.1999.17.2.658.

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PURPOSE: Topotecan and cyclophosphamide, doxorubicin, and vincristine (CAV) were evaluated in a randomized, multicenter study of patients with small-cell lung cancer (SCLC) who had relapsed at least 60 days after completion of first-line therapy. PATIENTS AND METHODS: Patients received either topotecan (1.5 mg/m2) as a 30-minute infusion daily for 5 days every 21 days (n = 107) or CAV (cyclophosphamide 1,000 mg/m2, doxorubicin 45 mg/m2, and vincristine 2 mg) infused on day 1 every 21 days (n = 104). Eligibility included the following: bidimensionally measurable disease, Eastern Cooperative Onc

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Jaenudin, M., and Ali Hamdan. "Penilaian Dampak Zakat, Infak, Sedekah Terhadap Kemiskinan Spiritual Dan Material Penerima Manfaat Laznas LMI: Pendekatan CIBEST." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 3 (2022): 362–78. http://dx.doi.org/10.20473/vol9iss20223pp362-378.

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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikat

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Jaenudin, M., and Ali Hamdan. "Penilaian Dampak Zakat, Infak, Sedekah Terhadap Kemiskinan Spiritual Dan Material Penerima Manfaat Laznas LMI: Pendekatan CIBEST." Jurnal Ekonomi Syariah Teori dan Terapan 9, no. 3 (2022): 362–78. http://dx.doi.org/10.20473/vol9iss20223pp362-378.

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ABSTRAK Kemisikinan merupakan suatu permasalahan yang harus ditemukan cara mengentaskannya. Islam agama yang sempurna telah memberikan solusi melalui instrument zakat, infak, dan sedekah. Tujuan dari penelitian ini adalah untuk menilai dampak zakat, infak, sedekah di LAZNAS LMI (Lembaga Manajemen Infaq) dengan Pendekatan CIBEST. Metode penelitian yang digunakan adalah kuantitatif dengan uji beda antara kondisi material dan spiritual mustahik sebelum dibantu dengan setelah disalurkan dana ZIS. Hasil analisis dari 355 penerima manfaat menunjukkan bahwa pada kuadran I, penerima manfaat yang dikat

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Linzey, Joseph R., Craig Williamson, Venkatakrishna Rajajee, Kyle Sheehan, B. Gregory Thompson, and Aditya S. Pandey. "Twenty-four–hour emergency intervention versus early intervention in aneurysmal subarachnoid hemorrhage." Journal of Neurosurgery 128, no. 5 (2018): 1297–303. http://dx.doi.org/10.3171/2017.2.jns163017.

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OBJECTIVERecent observational data suggest that ultra-early treatment of ruptured aneurysms prevents rebleeding, thus improving clinical outcomes. However, advances in critical care management of patients with ruptured aneurysms may reduce the rate of rebleeding in comparison with earlier trials, such as the International Cooperative Study on the Timing of Aneurysm Surgery. The objective of the present study was to determine if an ultra-early aneurysm repair protocol will or will not significantly reduce the number of incidents of rebleeding following aneurysmal subarachnoid hemorrhage (SAH).M

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TAGHI-ZADEH, TARANA GADIR. "EVALUATION OF THE INCIDENCE OF BRUCELLOSIS IN CHILDREN IN CONDITIONS OF INTENSIFICATION OF INDIVIDUAL LIVESTOCK BREEDING." Bulletin of Contemporary Clinical Medicine 16, no. 4 (2023): 58–62. http://dx.doi.org/10.20969/vskm.2023.16(4).58-62.

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Introduction. Despite not huge efforts to combat brucellosis, in a number of countries, including Azerbaijan, decisive positive results have not yet been achieved. Many households began to keep livestock, which could lead to an increased risk of brucellosis in children. Aim. Assessment the influence of individualization of livestock breeding on the incidence of brucellosis in children. Material and methods. The work was carried out in 14 settlements of the Baku urban agglomeration located on the Absheron Peninsula. An epidemiological survey was carried out on 486 individual farms, selected by

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Schaefer, A. L., S. R. Davis, and G. A. Hughson. "Estimation of tissue protein synthesis in sheep during sustained elevation of plasma leucine concentration by intravenous infusion." British Journal of Nutrition 56, no. 1 (1986): 281–88. http://dx.doi.org/10.1079/bjn19860107.

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1. The fractional rate of protein synthesis (FSR) was determined in skeletal muscle, liver, rumen and cardiac muscle of wether sheep by continuous intravenous infusion of L–[4,5–3H]leucine accompanied by infusion of 0, 7.6, 15.2 or 22.8 mmol leucine/h (three sheep per treatment). FSR was calculated assuming plasma (ksp) or intracellular (ksi) leucine-specific radioactivity (SRA) was representative of the leucine precursor pool SRA for protein synthesis.2. Plasma leucine concentration (plateau) was linearly related to leucine infusion rate, 22.8 mmol/h evoking tenfold increase in plasma concent

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De Agustin, J. J., G. Añez, D. Reina-Sanz, et al. "AB1116 APREMILAST IN PSORIATIC ARTHRITIS. ULTRASOUND ANALYSIS (JOINT-ENTHESES-UNGUEAL INDEX) OF THE EFFICACY AND VARIABLES CORRELATION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1787–88. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1397.

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BackgroundWe conducted a study using ultrasonography (US) to evidence inflammatory changes (joint-enthesis-ungueal) in active PsA (aPsA) patients who started Apremilast (A) in clinical practice.ObjectivesObtain a 20, 50, 70 % reduction in the US index (UIC) at 12 months, and study correlation between variables.MethodsPhase IV, multicenter, prospective and open-label clinical trialconductedin 9 centresfrom 2018 to 2021. All patients signed the informed consent. Approval by the ethical committee was obtained, code PSA-PI-006421. PsA patients (≥ 2 swollen joints), ≥ 2 joint US synovitis and ≥ 1 U

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Waikel, Rebekah L., Amna A. Othman, Tanviben Patel, et al. "Recognition of Genetic Conditions After Learning With Images Created Using Generative Artificial Intelligence." JAMA Network Open 7, no. 3 (2024): e242609. http://dx.doi.org/10.1001/jamanetworkopen.2024.2609.

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ImportanceThe lack of standardized genetics training in pediatrics residencies, along with a shortage of medical geneticists, necessitates innovative educational approaches.ObjectiveTo compare pediatric resident recognition of Kabuki syndrome (KS) and Noonan syndrome (NS) after 1 of 4 educational interventions, including generative artificial intelligence (AI) methods.Design, Setting, and ParticipantsThis comparative effectiveness study used generative AI to create images of children with KS and NS. From October 1, 2022, to February 28, 2023, US pediatric residents were provided images through

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Kwon, Taesung, Stacy Kenyon, Kimberly Kilheeney, Stanley Martin, and Mark Shelly. "Prevalence of SARS-CoV-2 Antibody in Healthcare Workers in Central Pennsylvania." Antimicrobial Stewardship & Healthcare Epidemiology 1, S1 (2021): s49. http://dx.doi.org/10.1017/ash.2021.93.

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Background: Determining the incidence of SARS-CoV-2 in healthcare workers (HCW) is important in assessing the safety of the work environment. Though of limited use in acute illness, serologic testing can detect some infections that occur undetected. We compared the prevalence of antibodies to SARS-CoV-2 to a place of work, exposure by role and department, and use of various prevention methods. Methods: Healthcare workers (HCWs) working in Geisinger Health System were offered voluntary serology through Employee Health. Before they had blood taken, they completed a brief questionnaire. Testing w

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Lazow, Margot, Andrew Trout, Christine Fuller, et al. "BIOM-42. IMMUNOHISTOCHEMICAL ASSESSMENT OF MEMBRANOUS SOMATOSTATIN TYPE 2A RECEPTOR (SST2A) EXPRESSION ACROSS HIGH-RISK PEDIATRIC CENTRAL NERVOUS SYSTEM (CNS) TUMORS." Neuro-Oncology 23, Supplement_6 (2021): vi20. http://dx.doi.org/10.1093/neuonc/noab196.073.

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Abstract INTRODUCTION 77Lu-DOTATATE, a radionuclide therapy which binds SST2A, has demonstrated efficacy in neuroendocrine tumors and evidence of CNS penetration, supporting potential expansion within pediatric neuro-oncology. Understanding the prevalence of SST2A expression across pediatric CNS tumors is essential to identify patients who may benefit from somatostatin receptor-targeted therapy and to further elucidate the oncogenic role of SST2A. METHODS SST2A immunohistochemistry (IHC) was performed on tumor specimens and interpreted by two experienced pathologists (blinded), utilizing semi-

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Chen, Jennifer Hechao, Kerollos Wanis, Mahdia Rahman, et al. "Implications for sentinel lymph node biopsy (SLNB) omission in patients with early-stage node-negative HR+/HER2- breast cancer undergoing mastectomy." Journal of Clinical Oncology 43, no. 16_suppl (2025): 580. https://doi.org/10.1200/jco.2025.43.16_suppl.580.

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580 Background: The SOUND and INSEMA trials demonstrated non-inferiority of SLNB omission in HR+/HER2- early-stage breast cancer (BC) patients with negative axillary ultrasound (AUS) undergoing breast conserving therapy (BCT). However, it remains unclear if this approach may be applied to patients receiving mastectomy. We evaluated outcomes in a similar patient population receiving BCT versus mastectomy. Methods: Using an institutional database (2010-2023), we identified patients with cT1N0M0 HR+/HER2- unifocal invasive ductal carcinoma with negative AUS who underwent upfront BCT (breast conse

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Wang, A., Y. Ding, and H. Cao. "DOP026 Porphyromonas gingivalis secreted htpG disrupts TLR4/ PAPSS2-mediated mucin sulfation and aggravates ulcerative colitis." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i132. https://doi.org/10.1093/ecco-jcc/jjae190.0065.

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Abstract Background The role of the oral microbiota in the development of IBD and its association with disease severity has been established. However, the specific impact and mechanism of Porphyromonas gingivalis (P.g), a major pathogenic bacteria in the oral cavity, in exacerbating colitis remain unclear. Our objective is to investigate how P.g exacerbates ulcerative colitis. Methods Fecal samples were collected from patients with active ulcerative colitis and compared to those from healthy controls to assess the abundance of P.g. The impact of P.g on colitis and the colonic mucosal barrier w

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Shaib, Walid Labib, Ali Roberts, Katerina Mary Zakka, et al. "Blood-based next-generation sequencing analysis of neuroendocrine tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 4110. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.4110.

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4110 Background: Neuroendocrine tumors (NET) comprise around 2% of all malignant tumors of the gastrointestinal system. The genomic landscape of NET has not been well studied. The aim of this study was to confirm the feasibility of next generation sequencing (NGS) using ctDNA in NET and characterize common alterations in the genomic profile. Methods: Molecular alterations in 114 plasma samples from 114 patients with NET using clinical-grade NGS of ctDNA (Guardant360Ò) across multiple institutions were evaluated. The test detects single nucleotide variants in 54-73 genes, copy number amplificat

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Cipolletta, E., A. DI Matteo, E. Filippucci, and W. Grassi. "THU0420 ULTRASOUND SHOWS GREAT ACCURACY FOR THE DIAGNOSIS OF CRYSTAL ARTHRITIS IN PATIENTS WITH RECENT-ONSET SYNOVITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 448.1–448. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1100.

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Background:The value of ultrasound (US) in the diagnosis of crystal arthropathy, such as gout or calcium pyrophosphate deposition disease (CPPD), in patients with recent onset synovitis has been evaluated only by a few studies.Objectives:To investigate, in patients with acute arthritis, the accuracy of US for the diagnosis of crystal arthropathy.Methods:Consecutive patients with recent onset (<6 weeks) acute arthritis were enrolled. The US examinations were performed a rheumatologist blinded to clinical data. Calcium pyrophosphate and monosodium urate crystal deposits were identified in the

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Şan, S., Ö. Özdemir Işik, A. Yazici, and A. Cefle. "AB0362 DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF BEHCET’S DİSEASE PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1206.2–1207. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1543.

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Background:Behcet’s Disease (BD) is a systemic variable vessel vasculitis that involves the skin, mucosa, joints, eyes, arteries, veins, nervous system and the gastrointestinal system.Objectives:In this study we aimed to present variety of involvements in patients who were followed up in our outpatient clinic with a diagnosis of BD.Methods:Data of 394 patients diagnosed with BD between 2000-2020 were retrospectively reviewed clinical, demographic characteristics and systemic involvements.Results:In our study 43.7% of BD patients were female, 56.3% were male and the mean age was 40±11years, dis

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RASUL, ZAHID, NASIM AHMAD, and MUHAMMAD ANZAR. "Changes in Motion Characteristics, Plasma Membrane Integrity, and Acrosome Morphology During Cryopreservation of Buffalo Spermatozoa." Journal of Andrology 22, no. 2 (2001): 278–83. http://dx.doi.org/10.1002/j.1939-4640.2001.tb02181.x.

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ABSTRACT: Motion characteristics, plasma membrane integrity, and acrosome morphology of buffalo spermatozoa after different stages of cryopreservation (ie, dilution, cooling to 4°C, equilibration at 4°C, and freezing and thawing) were examined. Semen ejaculates from 4 buffalo bulls were pooled (n = 5), diluted in triscitric acid extender, cooled to 4°C over 2 hours, equilibrated at 4°C for 4 hours, dispensed into 0.5‐mL straws, and frozen in a programmable cell freezer before plunging into liquid nitrogen. Frozen semen was thawed at 37°C for 15 seconds. After completion of each stage, sperm mo

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McCartney, Danielle, Christopher Irwin, Gregory R. Cox, and Ben Desbrow. "Fluid, energy, and nutrient recovery via ad libitum intake of different commercial beverages and food in female athletes." Applied Physiology, Nutrition, and Metabolism 44, no. 1 (2019): 37–46. http://dx.doi.org/10.1139/apnm-2018-0176.

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This study investigated the effect of consuming different commercial beverages with food ad libitum after exercise on fluid, energy, and nutrient recovery in trained females. On 4 separate occasions, 8 females (body mass (BM): 61.8 ± 10.7 kg; maximal oxygen uptake: 46.3 ± 7.5 mL·kg−1·min−1) lost 2.0% ± 0.3% BM cycling at ∼75% maximal oxygen uptake before completing a 4-h recovery period with ad libitum access to 1 of 4 beverages: Water, Powerade (Sports Drink), Up & Go Reduced Sugar (Lower Sugar (LS)-MILK) or Up & Go Energize (Higher Protein (HP)-MILK). Participants also had two 15-min

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Diklic, Aleksandar, Vladan Zivaljevic, Ivan Paunovic, Nevena Kalezic, and Svetislav Tatic. "Surgical procedures in patients with thyroid autoimmune disease." Srpski arhiv za celokupno lekarstvo 133, Suppl. 1 (2005): 77–83. http://dx.doi.org/10.2298/sarh05s1077d.

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Autoimmune thyroid disease is a serious medical problem in which various operative procedures are performed. The objective of the study is to explore the type of applied surgical procedures in autoimmune thyroid disease, advantages and disadvantages of various procedures, and criteria they have to meet. This is retrospective clinical study on 1478 patients, operated for Graves? toxic goiter (117 males and 795 females mean age 37.7) and Hashimoto thyroiditis (27 males and 539 females mean age 50.6) from 1995 to April 2005. Cancer in Graves? disease was found in 61 patients (6.7%), papillary in

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Hoque, Md Ikram Ul, Andrew Gibson, and Scott Donne. "SnO₂-QDs/Rgo Nanocomposites for Lithium Ion Battery Anodes." ECS Meeting Abstracts MA2022-02, no. 7 (2022): 2519. http://dx.doi.org/10.1149/ma2022-0272519mtgabs.

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SnO2 is one of the most efficient materials for lithium ion battery (LIBs) anodes as it can theoretically provide a reversible capacity of 790 mAh/g (graphite, 372 mAh/g) for alloying reaction with lithium ion [(i) SnO 2 + 4 Li+ + 4e - = 2Li 2 O + Sn, (ii) Sn + xLi+ + xe- = LixSn (0 ≤ x ≤ 4.4)] during charge-discharge process [1]. In addition, SnO2 shows lowest operating potentials (average charge and discharge potentials: 0.3 V and 0.5 V vs. Li/Li+, respectively) in comparison with other transition metal oxides, facilitating a higher energy density when a full cell is constructed [2]. However

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Patenaude, Jan, Gustavo Zarini, Michael McLean, and Susan Linke. "Effectiveness of a Tailored Dietary Program in Subjects With Fibromyalgia." Current Developments in Nutrition 5, Supplement_2 (2021): 856. http://dx.doi.org/10.1093/cdn/nzab047_019.

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Abstract Objectives We examined the effects of the Lifestyle Eating and Performance (LEAP) program to alleviate fibromyalgia-related symptoms. Methods The retrospective study included de-identified data of 33 subjects with fibromyalgia. Dietitians used the in-vitro Leukocyte Activation Assay-MRT (LAA-MRT) blood test results to develop the tailored LEAP program for each subject. The LAA-MRT measures white blood cells reactivity to scale the degree of an adverse immune response to 150 food and food-chemical antigens. The LEAP program is based on the principles of the oligoantigenic dietary appro

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Yagi, S., H. Fukui, K. Yokoyama, et al. "P636 Comparison of the real-world efficacy of filgotinib with tofacitinib in patients with refractory ulcerative colitis: A single-center retrospective study." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i1219. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0766.

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Abstract Background Several Janus kinase inhibitors have recently been launched for the treatment of ulcerative colitis (UC). However, there are few reports comparing the efficacy and safety of each drug in patients with refractory UC, especially with filgotinib (FIL), which was recently launched and can be concomitantly used with thiopurines. We herein aimed to compare the real-world efficacy and safety of tofacitinib (TOF) and FIL in induction therapy for patients with refractory UC. Methods Patients with refractory UC, who received either TOF 20mg/day or FIL 200mg/day from May 2018 to Octob

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Lebrethon, Marie-Christine, Ashley B. Grossman, Farhad Afshar, P. Nicholas Plowman, G. Michael Besser, and Martin O. Savage. "Linear Growth and Final Height after Treatment for Cushing’s Disease in Childhood." Journal of Clinical Endocrinology & Metabolism 85, no. 9 (2000): 3262–65. http://dx.doi.org/10.1210/jcem.85.9.6817.

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Abstract Cushing’s disease is associated with growth failure in childhood and adolescence. Growth and final height were analyzed in 10 patients who were cured or in remission after treatment of Cushing’s disease. Seven males and 3 females, aged 6.8–17.6 yr (bone age, 3.3- 15.4 yr), had transsphenoidal surgery, which was combined with pituitary irradiation (4500 cGy in 25 fractions) in 5 patients. At presentation, 5 patients were prepubertal (males), and 5 were pubertal (2 males and 3 females). The mean height sd score was −2.15 ± 1.26 (range, −0.21 to −4.32) compared with mean target height sd

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Rivera Teran, V., M. Pérez Rodríguez, D. Alpizar-Rodriguez, et al. "AB1229 SAFETY OF BIOSIMILAR ETANERCEPT IN THE TREATMENT OF RHEUMATIC DISEASES: DATA FROM THE MEXICAN ADVERSE EVENTS REGISTRY (BIOBADAMEX)." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1905.1–1906. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3819.

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Background:Access to biosimilar drugs in Mexico started on 2014. Although biosimilar drugs safety has proved comparability to originator drugs on trials, information about its safety on real-life data is limited.Objectives:To compare safety in terms of adverse events of biosimilar etanercept (BEt) to originator etanercept (OEt) using information from the Mexican Adverse Events Registry (BIOBADAMEX).Methods:BIOBADAMEX is a Mexican cohort that collects the information of biologic and biosimilar drugs used in patients with rheumatic diseases in public and private practice since 2016. Patients enr

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Latagliata, R., M. Breccia, P. Fazi, et al. "Therapy-Related Myelodysplastic Syndrome (sMDS) /Acute Myelogenous Leukemia (sAML) in Acute Promyelocytic Leukemia (APL) Patients with Long-Lasting Molecular Remission: The GIMEMA Experience." Blood 106, no. 11 (2005): 884. http://dx.doi.org/10.1182/blood.v106.11.884.884.

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Abstract The occurrence of a sMDS in patients potentially cured from a previous APL has been recently reported. To evaluate the real incidence and the clinical characteristics of sMDS/sAML post APL, the follow-up of 336 patients with newly diagnosed APL enrolled by 22 GIMEMA Centers in the LAP AIDA 0493 protocol has been revised. After the induction, 314 patients (93.4%) achieved complete remission (CR): of them, 225 (71.6%) are still alive in 1st CR, 12 (3.8%) died in CR and 71 (22.7%) relapsed. The remaining 6 patients (1.9%) developed a sMDS while in 1st morphological CR, after a median tim

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Mashayekhi, Mona, Hui Nian, Sara E. Howard, et al. "LBSUN306 Effects Of Glp-1 Receptor Agonism, Dpp4 Inhibition, And Hypocaloric Diet On Metabolic Parameters In Obese Pre-diabetic Individuals: A Randomized-controlled Trial." Journal of the Endocrine Society 6, Supplement_1 (2022): A292—A293. http://dx.doi.org/10.1210/jendso/bvac150.603.

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Abstract Background GLP-1 receptor (GLP1R) agonists reduce glucose, weight and cardiovascular risk. Understanding the weight loss-dependent mechanisms of these benefits will inform treatment and drug development. This study compared metabolic responses among GLP1R agonist (liraglutide), DPP4 inhibitor (sitagliptin), and hypocaloric diet treatments. Methods We randomized 88 obese, pre-diabetic individuals in a 2: 1: 1 ratio to liraglutide, sitagliptin, or diet for 14 weeks. Treatment was double-blinded and placebo-controlled for drug. Individuals completed a mixed meal at baseline, 2 and 14 wee

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Gouda, Mohamed A., Blessie E. Nelson, Lars Buschhorn, Adam Wahida, and Vivek Subbiah. "Abstract 1173: Landscape of 4,506 pan-cancer samples harboring BRAFV600E mutations, and NTRK/RET Fusions from 137,401 adult patients with cancer: Clinical implications for tissue agnostic therapies." Cancer Research 83, no. 7_Supplement (2023): 1173. http://dx.doi.org/10.1158/1538-7445.am2023-1173.

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Abstract Background: Biomarker-driven trials have led to multiple FDA tissue-agnostic approvals. We aimed to explore the clinic-genomic landscape of alterations currently actionable by tissue-agnostic targeted therapies. Methods: We mined AACR Project GENIE to extract data about three molecular targets currently on the list of FDA tissue-agnostic approvals (RET fusions, NTRK fusions, and BRAFV600E mutations). Results: Among 137401 patients in GENIE database (153,834 samples), 4506 samples harbored BRAFV600E mutations (3%), 390 had NTRK fusions (0.3%), and 375 had RET fusions (0.2%) (Table 1).

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Gleeson, Mary, David Cunningham, Eliza A. Hawkes, et al. "Risk of CNS Relapse with Diffuse Large B-Cell Lymphoma (DLBCL) in the Rituximab Era: Results from the UK NCRI R-CHOP 14 v 21 Trial." Blood 124, no. 21 (2014): 1723. http://dx.doi.org/10.1182/blood.v124.21.1723.1723.

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Abstract Background: Central Nervous System (CNS) relapse of Diffuse Large B-cell Lymphoma (DLBCL) is associated with a poor prognosis. Prior to the advent of rituximab the incidence of CNS relapse without CNS prophylaxis was around 5% in most unselected series. The risk in the rituximab era appears to be decreased in some but not all reported series (2.2-6.4%). CNS prophylaxis may be administered to patients deemed to be at high-risk but indications are not standardised. Methods: The randomised phase III UK R-CHOP-14 vs 21 trial assessed rituximab, cyclophosphamide, doxorubicin, vincristine,

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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Abreu, Milena Reis, Larissa Paiva, Tamires Costa Mendes, et al. "Risk Factors for Surgical Site Infection After Orthopedic Trauma Surgery: A Two-Year Prospective Multicenter Analysis." Infection Control & Hospital Epidemiology 41, S1 (2020): s377—s378. http://dx.doi.org/10.1017/ice.2020.1010.

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Background: Trauma is defined by the NHSN as “blunt or penetrating traumatic injury.” Therefore, if the surgery was performed because of a recent fall, for example, then it is a trauma surgery. Here, we investigated which preoperative and operative parameters are associated with surgical site infection (SSI) after orthopedic trauma surgery. Objective: We aimed to answer 3 main questions: What is the risk of wound infection for patients undergoing trauma surgery? What are the main etiologic agents of SSI after trauma surgery? And what are the risk factors associated with SSI after trauma surger

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Peters, Dr, Peter Bader, Ulrike Pötschger, et al. "Similar Overall Survival and Event-Free Survival for Patients Under or over the Age of 14 Years, but More Chronic Graft Versus Host Disease and Non-Relapse Mortality in the “Older” Patients." Blood 142, Supplement 1 (2023): 3548. http://dx.doi.org/10.1182/blood-2023-185870.

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Purpose: In the prospective, randomized, multinational FORUM trial, total body irradiation and etoposide were statistically more effective than chemoconditioning (Peters et al, JCO 2021; FORUM study; EudraCT: 2012-003032-22; ClinicalTrials.gov: NCT01949129). The multivariate analysis in this cohort showed an inferior overall survival (OS) for patients (pts) over the age of 10 years, HR 1.8 (95% CI, p=0.048). To update these findings, we examine the impact of age at allogeneic hematopoietic stem cell transplantation (HSCT), we analyzed 791 FORUM pts who received TBI and etoposide as conditionin

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Vazquez, J. M., E. A. Martinez, I. Parrilla, et al. "352 IMPROVING THE EFFICIENCY OF LAPAROSCOPIC INTRAOVIDUCTAL INSEMINATION WITH SEX-SORTED BOAR SPERMATOZOA." Reproduction, Fertility and Development 18, no. 2 (2006): 283. http://dx.doi.org/10.1071/rdv18n2ab352.

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The insemination of a low number of sex-sorted spermatozoa is a critical issue that must be solved in order to enable the commercial application of this technology in pigs. A new procedure for laparoscopic intraoviductal insemination in sows has recently been reported (Vazquez et al. 2005 Reprod. Dom. Animals 40, 375 abst.). To improve the efficiency of this technique, this experiment was designed to determine the influence of insemination time, relative to the time of ovulation, on the number and quality of zygotes recovered after laparoscopic insemination of sows with sex-sorted spermatozoa.

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Ahmadi, Tahamtan, Elise A. Chong, Amanda Gordon, et al. "Phase II Trial of Lenalidomide - Dexamethasone - Rituximab in Relapsed or Refractory Indolent B-Cell or Mantle Cell Lymphomas Resistant to Rituximab." Blood 114, no. 22 (2009): 1700. http://dx.doi.org/10.1182/blood.v114.22.1700.1700.

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Abstract Abstract 1700 Poster Board I-726 Introduction Lenalidomide is an immunomodulatory drug with effects on the innate immune system that may enhance antibody-dependent cell mediated cytotoxicity as well as the development of specific anti-tumor immune responses. These immunologic effects may synergize with the action of rituximab. To test the efficacy of lenalidomide combined with rituximab, we are conducting a single center, open label phase II clinical trial in patients (pts) with indolent B-cell or mantle cell lymphomas previously resistant to rituximab. Patients and Methods Eligible p

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Schulman, Sam, Henry Eriksson, Samuel Z. Goldhaber, et al. "Influence of Thrombophilia on the Efficacy of Dabigatran Versus Warfarin for the Extended Treatment of Acute Venous Thromboembolism in RE-MEDY™." Blood 124, no. 21 (2014): 1544. http://dx.doi.org/10.1182/blood.v124.21.1544.1544.

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Abstract Background: Dabigatran etexilate (DE) was noninferior to warfarin for the prevention of recurrent venous thromboembolism (VTE), with a lower risk of bleeding, when administered as extended treatment for VTE in the RE-MEDY™ study (in which we evaluated long-term extension of treatment with dabigatran compared with warfarin). Objectives: Thrombophilia is a major risk factor for VTE recurrence. Therefore, we performed a post-hocsubgroup analysis on data from RE-MEDY™ to investigate the efficacy of DE versus warfarin in patients with and without thrombophilia (congenital or acquired) at b

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Chamseddine, Sarah, Haniah A. Zaheer, John V. Williams, Judith M. Martin, Anne-Marie Rick, and Hui Liu. "1328. Risk Factors for Severe Influenza Outcomes Among Infants Born Between 2011 and 2019." Open Forum Infectious Diseases 8, Supplement_1 (2021): S752. http://dx.doi.org/10.1093/ofid/ofab466.1520.

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Abstract Background Influenza in infancy can cause significant morbidity and mortality. This study aimed to characterize influenza outcomes in infants &lt; ορ = 12 months and identify risk factors for severe infection. Methods A retrospective cohort of infants ≤ 12 months born between 2011-2019 who received longitudinal ambulatory and inpatient care within a multi-facility hospital system and had laboratory-confirmed influenza were included. Perinatal, medical and illness characteristics were described. Risk factors for severe influenza (hospitalization, intensive-care unit (ICU) admission

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Pain, C., A. Murray, G. Dinsdale, A. Marsden, J. Manning, and A. Herrick. "POS1304 CORRELATION OF SKIN SCORES (LoSCAT) WITH PATIENT REPORTED OUTCOMES IN JUVENILE LOCALISED SCLERODERMA." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 990.1–990. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1553.

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BackgroundJuvenile localised scleroderma (JLS) or morphea is a rare condition, causing inflammation and fibrosis in skin and underlying tissues. A validated skin score (Localized Scleroderma Cutaneous Assessment Tool, LoSCAT) has been developed [1]. This tool has both activity (mLoSSi) and damage indices (LoSDI). Several patient-reported outcomes (PRO) have been studied in JLS including visual analogue scales (VAS), functional and health-related quality of life measures.ObjectivesTo assess the associations between different PROs and the activity and damage indices of the LoSCAT.MethodsParticip

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Kaufman, Jonathan L., Saad Z. Usmani, Jesús San-Miguel, et al. "Four-Year Follow-up of the Phase 3 Pollux Study of Daratumumab Plus Lenalidomide and Dexamethasone (D-Rd) Versus Lenalidomide and Dexamethasone (Rd) Alone in Relapsed or Refractory Multiple Myeloma (RRMM)." Blood 134, Supplement_1 (2019): 1866. http://dx.doi.org/10.1182/blood-2019-123483.

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Introduction: Daratumumab, a human IgGκ monoclonal antibody targeting CD38 with a direct on-tumor and immunomodulatory mechanism of action, is approved in combination with standard-of-care regimens for the treatment of newly diagnosed multiple myeloma (NDMM) and RRMM. When combined with standard of care regimens across four phase 3 studies, daratumumab demonstrated ≥44% reductions in the risk of progression or death, nearly doubled complete response (CR) or better rates, and tripled minimal residual disease (MRD)-negative rates at the 10-5 sensitivity threshold in pts with RRMM or NDMM (Palumb

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Lopez Salazar, Javier, Laura A. Ramirez Tirado, Nora Gomez Contreras, Oscar Arrieta, Dolores Gallardo, and Gabriela Cesarman-Maus. "Leukocytosis, but Not Thrombocytosis, May Constitute a Prothrombotic Pathway in Women with Ovarian Cancer: A Cohort Study." Blood 132, Supplement 1 (2018): 1228. http://dx.doi.org/10.1182/blood-2018-99-120193.

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Abstract Venous thromboembolism (VTE) occurs at a higher rate in cancer patients and is frequently associated with well-known prothrombotic risk factors such as prolonged bed rest, central venous catheters, diverse oncological treatments and invasive procedures. Patients may share one or more risk factors. In addition, there seem to be tumor-driven prothrombotic pathways. Thus different tumors may promote activation of coagulation either directly through the expression of procoagulant molecules such as tissue factor or indirectly through the secretion of factors that in turn induce thrombocyto

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Porter, J., C. Borgna-Pignatti, M. Baccarani, et al. "Iron Chelation Efficiency of Deferasirox (Exjade®, ICL670) in Patients with Transfusional Hemosiderosis." Blood 106, no. 11 (2005): 2690. http://dx.doi.org/10.1182/blood.v106.11.2690.2690.

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Abstract Iron excretion can be calculated according to Angelucci et al (NEJM 2000). As applied to the novel oral iron chelator deferasirox (DSX), chelation efficiency can then be determined as the % iron excretion vs theoretical iron binding capacity of chelator dose: % efficiency = [iron excretion (mg/kg/day)/chelator dose (mg/kg/day)] x [374/56] x 2 x 100 (374 and 56 represent the molecular weights of DSX and iron; factor 2 accounts for the tridentate ligand). In a total of 325 patients with β-thalassemia (n=285) or rare anemias, such as MDS (n=13), DBA (n=14) or other anemias (n=13), includ

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Cavo, Michele, Valerio De Stefano, Angel Ramirez Payer, et al. "Safety Profile for Lenalidomide-Based and Non-Lenalidomide-Based First-Line Therapy for Multiple Myeloma in Transplant Ineligible Patients: Real-World Evidence from a European Post-Authorization Safety Study." Blood 134, Supplement_1 (2019): 5580. http://dx.doi.org/10.1182/blood-2019-124555.

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BACKGROUND: Real-world data can provide important information on the safety profile for recommended treatment options, but these data are collected infrequently. The ongoing post-authorization safety study (PASS) MM-034 (NCT03106324) is a prospective non-interventional study in patients (pts) with newly diagnosed multiple myeloma (NDMM) who are transplant ineligible. This study allows for the collection of robust safety data for currently recommended regimens for the management of these pts. Global guidelines recommend lenalidomide (LEN) regimens, such as LEN plus dexamethasone (DEX; Rd) and L

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Galindez, E., D. Prieto-Peña, J. L. Martín-Varillas, et al. "AB0768 TREATMENT WITH TOFACITINIB IN REFRACTORY PSORIATIC ARTHRITIS. MULTICENTER STUDY OF 87 PATIENTS IN CLINICAL PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1682.1–1682. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2903.

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Background:Tofacitinib (TOFA) is the first JAKi approved for psoriatic arthritis (PsA) in Europe (July 2018). TOFA has shown efficacy in refractory patients to anti-TNF in Randomized Clinical Trials (RCT) (Gladman D. NEJM 2017; 377: 1525-36).Objectives:To assess efficacy and safety of TOFA in clinical practice (CP). To compare the profile of CP with RCTMethods:Study of 87 patients of CP with PsA treated with TOFA; Results are expressed as percentage, mean±SD or median [IRQ].Results:87 patients (28♀/59♂), mean age of 52.8±11.4 years (Table 1). Pattern of joint involvement was: peripheral (n=60)

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