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Journal articles on the topic '796.526 (043.2)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Ćirić, Aleksandar, Jelena Aleksić, Tanja Barudžija, et al. "Comparison of Three Ratiometric Temperature Readings from the Er3+ Upconversion Emission." Nanomaterials 10, no. 4 (2020): 627. http://dx.doi.org/10.3390/nano10040627.

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The emission of Er3+ provides three combinations of emission bands suitable for ratiometric luminescence thermometry. Two combinations utilize ratios of visible emissions (2H11/2→4I15/2 at 523 nm/ 4S3/2→4I15/2 at 542 nm and 4F7/2→4I15/2 at 485 nm/ 4S3/2→4I15/2 at 545 nm), while emissions from the third combination are located in near-infrared, e.g., in the first biological window (2H11/2→4I13/2 at 793 nm/ 4S3/2→4I13/2 at 840 nm). Herein, we aimed to compare thermometric performances of these three different ratiometric readouts on account of their relative sensitivities, resolutions, and repea

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Bowmaker, Graham A., Jack M. Harrowfield, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. II Bipyridinium (2,2' Bipyridine) tetraholobismuthate (III) (Halogen = Chloride or Bromide)." Australian Journal of Chemistry 51, no. 4 (1998): 311. http://dx.doi.org/10.1071/c97037.

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Syntheses and room-temperature single-crystal X-ray structure determinations are recorded for the title compounds, [bpyH]+[(bpy)BiX4]-, X = Cl, Br, the chloride being obtained in a second acetonitrile- sesquisolvated form. [bpyH]+[(bpy)BiX4]-, X = Cl, Br, are isomorphous, monoclinic C2/c, a ≈ 15·3, b ≈ 9·6, c ≈ 16·8 Å, β 109°, Z = 4, conventional R on |F| being 0·056, 0·059 for No 1456, 769 independent ‘observed’ (I > 3σ(I)) reflections respectively. [bpyH] [(bpy)BiCl4].1½MeCN is monoclinic, P21/m, a 9·572(2), b 34·521(8) c 8·218(2) Å, β 102·13(2)°, Z = 4, R 0·043 for No 2635. All anionic s

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Ćirić, Aleksandar, Jelena Aleksić, Tanja Barudžija, et al. "Comparison of Three Ratiometric Temperature Readings from the Er3+ Upconversion Emission." Nanomaterials 10, no. 4 (2020): 627. https://doi.org/10.5281/zenodo.3899751.

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Manuscript published in the Open Access Journal: Ćirić, A.; Aleksić, J.; Barudžija, T.; Antić, Ž.; Đorđević, V.; Medić, M.; Peri&scaron;a, J.; Zeković, I.; Mitrić, M.; Dramićanin, M.D. Comparison of Three Ratiometric Temperature Readings from the Er<sup>3+</sup> Upconversion Emission. Nanomaterials 2020, 10, 627; https://doi.org/10.3390/nano10040627 This article belongs to the Special Issue Luminescent Rare-Earth-Based Nanomaterials The emission of Er3+ provides three combinations of emission bands suitable for ratiometric luminescence thermometry. Two combinations utilize ratios of visible em

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Caillet, Philippe, Florence Canoui-Poitrine, Johanna Vouriot, et al. "Comprehensive Geriatric Assessment in the Decision-Making Process in Elderly Patients With Cancer: ELCAPA Study." Journal of Clinical Oncology 29, no. 27 (2011): 3636–42. http://dx.doi.org/10.1200/jco.2010.31.0664.

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Purpose To identify Comprehensive Geriatric Assessment (CGA) components independently associated with changes in planned cancer treatment. Patients and Methods We prospectively included 375 consecutive elderly patients with cancer (ELCAPA01 study) assessed by geriatricians using the CGA. Multivariate analysis was used to identify factors associated with changes in the cancer treatment (intensification, decrease, or delayed > 2 weeks). Change was defined as a difference between the initial treatment proposal and the final treatment selected in a multidisciplinary meeting. Results Mean age wa

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Zhong, Runbo, Min Yan, Qiming Wang, et al. "Phase 1 trial of SHR-A2102, a nectin-4–directed antibody drug conjugate (ADC), in advanced solid tumors." Journal of Clinical Oncology 43, no. 16_suppl (2025): 107. https://doi.org/10.1200/jco.2025.43.16_suppl.107.

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107 Background: Nectin-4 is a cell adhesion molecule that is highly expressed in a wide variety of cancers and is associated with poor prognosis. SHR-A2102 is a novel ADC consisting of a fully humanized Nectin-4–directed monoclonal antibody, bound to topoisomerase I inhibitor payload via a cleavable linker. We conducted a multi-center, phase 1 trial to evaluate SHR-A2102 in advanced solid tumors. Methods: Patients (pts) with Nectin-4 positive, locally advanced unresectable or metastatic solid tumors were enrolled. The study included dose-escalation (D-ESC), dose-expansion (D-EXP) and efficacy-

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Luo, Jing, Geng-Si Xi, Shu-Min Lü, Ke Li, and Qing Li. "Molecular cloning, characterization, and expression analysis of a novel sema-2a homologue in Polyrhachis vicina (Hymenoptera: Formicidae)." Canadian Entomologist 142, no. 1 (2010): 1–13. http://dx.doi.org/10.4039/n09-046.

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AbstractThe semaphorin gene family plays important roles in axonal guidance in vertebrates and invertebrates. Semaphorin 2a, a member of the semaphorin family, belongs to class 2, which is found only in invertebrates. In our study, semaphorin 2a was cloned from the ant Polyrhachis vicina Roger. The full length of P. vicina semaphorin 2a (Pv-sema-2a) is 2763 base pairs (bp) and it contains a 5′-untranslated region (UTR) 92 bp long and a 3′-UTR 521 bp long. The open reading frame of Pv-sema-2a encodes a 716-amino-acid protein with a predicted molecular mass of 81.1 kilodaltons. Real-time quantit

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Margolies, L., A. Cohen, E. Sonnenblick, et al. "Digital Breast Tomosynthesis Changes Management in Patients Seen at a Tertiary Care Breast Center." ISRN Radiology 2014 (March 3, 2014): 1–8. http://dx.doi.org/10.1155/2014/658929.

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Objectives. To study factors that predict changes in management with digital breast tomosynthesis (DBT). Methods. The Institutional Review Board approved this HIPAA compliant study. 996 patients had DBT with full field digital mammography (FFDM). Univariate analysis evaluated predictors of management change and cancer detection. Results. DBT changed management in 109 of 996 (11%); 77 (71%) required less imaging. Recalled patients after abnormal FFDM screen were most likely to have management change—25% (24 of 97 patients) compared to 8% (13/163) of symptomatic patients and 10% (72/736) of scre

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den Braber, Niala, Carlijn I. R. Braem, Miriam M. R. Vollenbroek-Hutten, et al. "Consequences of Data Loss on Clinical Decision-Making in Continuous Glucose Monitoring: Retrospective Cohort Study." Interactive Journal of Medical Research 13 (July 31, 2024): e50849. http://dx.doi.org/10.2196/50849.

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Background The impact of missing data on individual continuous glucose monitoring (CGM) data is unknown but can influence clinical decision-making for patients. Objective We aimed to investigate the consequences of data loss on glucose metrics in individual patient recordings from continuous glucose monitors and assess its implications on clinical decision-making. Methods The CGM data were collected from patients with type 1 and 2 diabetes using the FreeStyle Libre sensor (Abbott Diabetes Care). We selected 7-28 days of 24 hours of continuous data without any missing values from each individua

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Rashid, Naziru, Aisha Nazziwa, Rehema Kantono, Hassan Kasujja, and Swaibu Zziwa. "Assessing Knowledge and Practices of the Community towards Corona Virus Disease 2019 in Mbale Municipality, Uganda: Across Section Study." East African Health Research Journal 5, no. 1 (2021): 20–25. http://dx.doi.org/10.24248/eahrj.v5i1.647.

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Background: The Corona virus disease, first identified in Wuhan city, Hubei province of China, is a respiratory illness caused by Novel Corona Virus also known as Severe Acute Respiratory Syndrome Corona Virus 2 (SARS Cov.2). The disease is characterised by; dry cough and shortness of breath with difficulty in breathing and at least 2 of the following; fever, chills, muscle pain, headache, sore throat and loss of test and smell. Uganda in general and Mbale in particular has people of diverse culture, religion and ethnic background as well as diverse socio economic activities with various pract

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KIM, JIN KYUNG, ELAINE M. D'SA, MARK A. HARRISON, JUDY A. HARRISON, and ELIZABETH L. ANDRESS. "Listeria monocytogenes Survival in Refrigerator Dill Pickles." Journal of Food Protection 68, no. 11 (2005): 2356–61. http://dx.doi.org/10.4315/0362-028x-68.11.2356.

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Listeria monocytogenes can survive and grow in refrigerated foods with pH values of approximately 4.0 to 5.0 and salt concentrations of 3 to 4%. Home-fermented refrigerator dill pickles fit this description. Contamination of this product with L. monocytogenes could cause serious problems because these items are not heated prior to consumption. L. monocytogenes survival and growth patterns were investigated in refrigerator dill pickles at 1.3, 3.8, and 7.6% salt concentrations. Pickling cucumbers were dipped into an inoculum of L. monocytogenes, brine mixtures were added, and cucumbers were hel

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De Agustin, J. J., G. Añez, D. Reina-Sanz, et al. "AB1116 APREMILAST IN PSORIATIC ARTHRITIS. ULTRASOUND ANALYSIS (JOINT-ENTHESES-UNGUEAL INDEX) OF THE EFFICACY AND VARIABLES CORRELATION STUDY." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 1787–88. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1397.

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BackgroundWe conducted a study using ultrasonography (US) to evidence inflammatory changes (joint-enthesis-ungueal) in active PsA (aPsA) patients who started Apremilast (A) in clinical practice.ObjectivesObtain a 20, 50, 70 % reduction in the US index (UIC) at 12 months, and study correlation between variables.MethodsPhase IV, multicenter, prospective and open-label clinical trialconductedin 9 centresfrom 2018 to 2021. All patients signed the informed consent. Approval by the ethical committee was obtained, code PSA-PI-006421. PsA patients (≥ 2 swollen joints), ≥ 2 joint US synovitis and ≥ 1 U

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Cummings, Garnet E., and Damon C. Mayes. "A comparative study of designated trauma team leaders on trauma patient survival and emergency department length-of-stay." CJEM 9, no. 02 (2007): 105–10. http://dx.doi.org/10.1017/s1481803500014871.

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ABSTRACT Objectives: There is controversy over who should serve as the Trauma Team Leader (TTL) at trauma-receiving centres. This study compared survival and emergency department (ED) length-of-stay between patients cared for by 3 different groups of TTLs: surgeons, emergency physicians (EPs) on call for trauma cases and EPs on shift in the ED. Methods: We performed a retrospective cohort study involving all adult major blunt trauma patients (aged 17 and older) who were admitted to 2 level I trauma centres and who were entered into a provincial Trauma Registry between March 2000 and April 2002

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Friedman, James M., Favian Su, Alan L. Zhang, et al. "Patient-Reported Activity Levels Correlate With Early Cartilage Degeneration After Anterior Cruciate Ligament Reconstruction." American Journal of Sports Medicine 49, no. 2 (2021): 442–49. http://dx.doi.org/10.1177/0363546520980431.

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Background: The association between activity level after anterior cruciate ligament (ACL) reconstruction (ACLR) and development of posttraumatic osteoarthritis (PTOA) remains unclear. This study investigated the relationship of patient-reported outcomes and progressive cartilage degenerative changes at 3 years after ACLR. Hypothesis: Higher activity levels, as measured by Marx scores, are significantly correlated with early cartilage degeneration after ACLR. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 35 patients (16 women; mean age, 31.0 ± 7.6 years) with isolated AC

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Siddiqui, S. H., N. Kumari, and N. Krishnani. "Histopathological Spectrum in Pancreaticoduodenectomy Specimens: Fifteen Year Study from a Tertiary Care Centre in North India." American Journal of Clinical Pathology 154, Supplement_1 (2020): S60. http://dx.doi.org/10.1093/ajcp/aqaa161.129.

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Abstract Introduction/Objective The periampullary region is histologically complex owing to the confluence of three different kinds of epithelia (duodenal, pancreatic, biliary) harbouring four types of cancers. Although anatomical proximity warrants a common surgical approach, overall survival depends largely on the type of surgical indication. Malignant epithelial tumors are the predominant indications, accompanied by a myriad of benign tumors and tumor-like lesions. We reviewed our archival pancreaticoduodenectomies to analyze the spectrum of these lesions. Methods All pancreaticoduodenectom

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Alexeeff, Stacey E., Kamala Deosaransingh, Stephen Van Den Eeden, Joel Schwartz, Noelle S. Liao, and Stephen Sidney. "Association of Long-term Exposure to Particulate Air Pollution With Cardiovascular Events in California." JAMA Network Open 6, no. 2 (2023): e230561. http://dx.doi.org/10.1001/jamanetworkopen.2023.0561.

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ImportanceLong-term exposure to fine particulate air pollution (PM2.5) is a known risk factor for cardiovascular events, but controversy remains as to whether the current National Ambient Air Quality Standard (12 μg/m3 for 1-year mean PM2.5) is sufficiently protective.ObjectiveTo evaluate the associations between long-term fine particulate air pollution and cardiovascular events using electronic health record and geocoded address data.Design, Setting, and ParticipantsThis retrospective cohort study included adults in the Kaiser Permanente Northern California integrated health care system durin

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Heathcote, Karen L., Merne P. Wilson, Dale W. Quest, and Thomas W. Wilson. "Prevalence and duration of exercise induced albuminuria in healthy people." Clinical & Investigative Medicine 32, no. 4 (2009): 261. http://dx.doi.org/10.25011/cim.v32i4.6616.

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Purpose: Vigorous exercise increases urine protein excretion. However, whether exercise increases urine albumin enough to reach the threshold for microalbuminuria (2.8 and 2.0 mg/mmol creatinine in women and men respectively) is uncertain. Furthermore, the duration of such albuminuria is unknown. We aimed to estimate the prevalence and duration of exercise induced microalbuminuria in normal healthy volunteers. Methods: Thirty normal subjects provided a urine sample, then exercised to maximal heart rate, or exhaustion, using the standard Bruce Treadmill protocol. Further urine samples were coll

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Cai, Qiuyin, Yu-Tang Gao, Wong-Ho Chow, et al. "Prospective Study of Urinary Prostaglandin E2 Metabolite and Colorectal Cancer Risk." Journal of Clinical Oncology 24, no. 31 (2006): 5010–16. http://dx.doi.org/10.1200/jco.2006.06.4931.

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Purpose Overexpression of cyclooxygenase-2 (COX-2) has been shown to play a major role in colorectal cancer pathogenesis. However, no human study has directly investigated whether biomarkers of COX-2 overexpression may predict colorectal cancer risk. We evaluated the association of urinary prostaglandin E2 metabolite (PGE-M) levels and colorectal cancer risk Methods A nested case-control study was conducted within the Shanghai Women's Health Study, in which 74,942 Chinese women ages 40 to 70 years were recruited from 1997 to 2000. Urinary PGE-M in 150 cohort members who developed colorectal ca

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Zhao, Wenxin, Yu Zhao, Yu Zheng, et al. "Long-term variability in black carbon emissions constrained by gap-filled absorption aerosol optical depth and associated premature mortality in China." Atmospheric Chemistry and Physics 24, no. 11 (2024): 6593–612. http://dx.doi.org/10.5194/acp-24-6593-2024.

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Abstract. Black carbon (BC) plays an important role in air quality, public health, and climate, but its long-term variations in emissions and health effects have been insufficiently understood for China. Here, we present the spatiotemporal evolution of BC emissions and the associated premature mortality in China during 2000–2020 based on an integrated framework combining satellite observations from the Ozone Monitoring Instrument (OMI), an extreme gradient boosting (XGBoost) algorithm, a “top-down” inversion approach, and an exposure–response model. We found that the “bottom-up” approach most

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Demetri, George D., Jason J. Luke, Antoine Hollebecque, et al. "First-in-human phase 1 study of ABBV-085, an antibody-drug conjugate (ADC) targeting LRRC15, in sarcomas and other advanced solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3004. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3004.

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3004 Background: ABBV-085 is an ADC (conjugated to monomethyl auristatin E, drug:antibody ratio of 2:1) directed against leucine-rich repeat containing 15 (LRRC15), a type 1 transmembrane protein highly expressed on the surface of sarcomas and cancer-associated fibroblasts in stroma of many other cancers. ABBV-085 induced antitumor activity in both in vitro and xenograft models of sarcoma. This phase 1, first-in-human, 2-part study assessed the safety/tolerability of ABBV-085 in patients (pts) with advanced solid tumors (NCT02565758). Methods: Eligible pts (≥18 yr; advanced solid tumors) recei

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Wadenvik, H., J. Kutti, B. Ridell, et al. "The effect of alpha-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia." Blood 77, no. 10 (1991): 2103–8. http://dx.doi.org/10.1182/blood.v77.10.2103.2103.

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Abstract In 10 patients with previously untreated essential thrombocythemia (ET), by using 111In-labeled platelets and megakaryocyte morphometry, the relation between platelet production rate and bone marrow megakaryocytes was evaluated before and during alpha-2b-interferon (IFN) therapy. A highly significant decrease in platelet count occurred during IFN therapy; the platelet counts, at baseline and after 2 and 6 months of IFN therapy, were 1,102 +/- 345 x 10(9)/L, 524 +/- 169 x 10(9)/L (P less than .0001), and 476 +/- 139 x 10(9)/L (P less than .0001), respectively. The decrement in platelet

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Wadenvik, H., J. Kutti, B. Ridell, et al. "The effect of alpha-interferon on bone marrow megakaryocytes and platelet production rate in essential thrombocythemia." Blood 77, no. 10 (1991): 2103–8. http://dx.doi.org/10.1182/blood.v77.10.2103.bloodjournal77102103.

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In 10 patients with previously untreated essential thrombocythemia (ET), by using 111In-labeled platelets and megakaryocyte morphometry, the relation between platelet production rate and bone marrow megakaryocytes was evaluated before and during alpha-2b-interferon (IFN) therapy. A highly significant decrease in platelet count occurred during IFN therapy; the platelet counts, at baseline and after 2 and 6 months of IFN therapy, were 1,102 +/- 345 x 10(9)/L, 524 +/- 169 x 10(9)/L (P less than .0001), and 476 +/- 139 x 10(9)/L (P less than .0001), respectively. The decrement in platelet count wa

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Lim, Sarah, Pamela Schreiner, Alan Lifson, et al. "527. Lower Risk of ICU Admission with Remdesivir in Patients Hospitalized with COVID-19 Pneumonia." Open Forum Infectious Diseases 8, Supplement_1 (2021): S364. http://dx.doi.org/10.1093/ofid/ofab466.726.

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Abstract Background Remdesivir (RDV) was approved by FDA in October 2020 for use in hospitalized patients with COVID-19. We examined the association between RDV treatment and ICU admission in patients hospitalized with COVID-19 pneumonia requiring supplemental oxygen (but not advanced respiratory support) in MN. Methods COVID-19-Associated Hospitalization Surveillance Network (COVID-NET) is population-based surveillance of hospitalized laboratory confirmed cases of COVID-19. We analyzed COVID-NET cases ≥18 years hospitalized between Mar 23, 2020 and Jan 23, 2021 in MN for which medical record

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Goebell, Peter J., Alexander Valerievich Sultanbaev, Anna Leena Brachtel, et al. "Real-world effectiveness and safety of avelumab first-line maintenance (1LM) treatment in patients with locally advanced or metastatic urothelial carcinoma (la/mUC): Second interim analysis of the AVENUE study." Journal of Clinical Oncology 43, no. 5_suppl (2025): 706. https://doi.org/10.1200/jco.2025.43.5_suppl.706.

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706 Background: Avelumab 1LM is standard of care for patients with la/mUC without disease progression after 1L platinum-based chemotherapy (PBC) based on results from the JAVELIN Bladder 100 phase 3 trial. The AVENUE study is evaluating the effectiveness and safety of avelumab 1LM treatment in routine clinical practice in Germany, Spain, Switzerland, and Russia. Previous results showed the acceptable safety profile of avelumab 1LM in a heterogeneous real-world population. Here, we report initial effectiveness data and updated baseline and safety data from the second interim analysis. Methods:

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Herfst, Lucas J., and Michael Brecht. "Whisker Movements Evoked by Stimulation of Single Motor Neurons in the Facial Nucleus of the Rat." Journal of Neurophysiology 99, no. 6 (2008): 2821–32. http://dx.doi.org/10.1152/jn.01014.2007.

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The lateral facial nucleus is the sole output structure whose neuronal activity leads to whisker movements. To understand how single facial nucleus neurons contribute to whisker movement we combined single-cell stimulation and high-precision whisker tracking. Half of the 44 stimulated neurons gave rise to fast whisker protraction or retraction movement, whereas no stimulation-evoked movements could be detected for the remainder. Direction, speed, and amplitude of evoked movements varied across neurons. Protraction movements were more common than retraction movements ( n = 16 vs. n = 4), had la

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De Souza, Jonas A., Brisa Aschebrook-Kilfoy, Raymon Grogan, Bonnie J. Yap, Christopher Daugherty, and David Cella. "Grading financial toxicity based upon its impact on health-related quality of life (HRQol)." Journal of Clinical Oncology 34, no. 3_suppl (2016): 16. http://dx.doi.org/10.1200/jco.2016.34.3_suppl.16.

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16 Background: Financial toxicity (FTox) is an important symptom. We hypothesized that FTox can be graded based on statistically significant and clinically meaningful changes in HRQoL. Methods: FTox was assessed by the COST (COmprehensive Score for financial Toxicity) in 2 sets of cancer patients (pts). Set 1(S1): pts with Stage IV cancers on chemotherapy. Gradations of FTox were determined by ROC analyses based on conventions for clinically meaningful small (0.2), medium (0.5) and large (0.8) effect sizes (e.s.) for the FACT-G HRQoL instrument. Demographics, income, mood disorders (POMS), and

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Patenaude, Jan, Gustavo Zarini, Michael McLean, and Susan Linke. "Effectiveness of a Tailored Dietary Program in Subjects With Fibromyalgia." Current Developments in Nutrition 5, Supplement_2 (2021): 856. http://dx.doi.org/10.1093/cdn/nzab047_019.

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Abstract Objectives We examined the effects of the Lifestyle Eating and Performance (LEAP) program to alleviate fibromyalgia-related symptoms. Methods The retrospective study included de-identified data of 33 subjects with fibromyalgia. Dietitians used the in-vitro Leukocyte Activation Assay-MRT (LAA-MRT) blood test results to develop the tailored LEAP program for each subject. The LAA-MRT measures white blood cells reactivity to scale the degree of an adverse immune response to 150 food and food-chemical antigens. The LEAP program is based on the principles of the oligoantigenic dietary appro

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Sasaki, Koji, Nina Shah, Qaiser Bashir, et al. "Outcome of Patients with Light Chain Multiple Myeloma Compared to IgG/IgA Myeloma after Autologous Stem Cell Transplant." Blood 126, no. 23 (2015): 3194. http://dx.doi.org/10.1182/blood.v126.23.3194.3194.

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Abstract Introduction: High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HCT) is the standard of care for younger patients with newly diagnosed multiple myeloma (MM). In approximately 15% of MM patients the monoclonal (M) spike consists of k or l light chains only as opposed to heavy + light chains. It remains unclear whether light chain (LC) MM has a different prognosis compared to other monoclonal protein subtypes after an auto-HCT. Methods: We retrospectively analyzed 1067 patients with MM who underwent auto-HCT between January 1, 2004 and January 1

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Kapoor, Vishal, Jana Cole, F. Frank Isik, Mika Sinanan, and David Flum. "Does the Use of a Flap during Abdominoperineal Resection Decrease Pelvic Wound Morbidity?" American Surgeon 71, no. 2 (2005): 117–22. http://dx.doi.org/10.1177/000313480507100205.

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We hypothesized that the use of muscle flaps, known as tissue transfer (TT), at the time of abdominoperineal resection (APR) reduces perineal wound complications. A restrospective review of patients undergoing an APR at the University of Washington (1984–2003) was conducted. Perineal wound complications and eventual wound healing were compared in patients with and without TT. Ninety-two patients (mean age, 56.6 years) underwent APR; 23.9 per cent (n = 22) had concurrent TT. Patients undergoing TT were more likely to have cancer (91% vs. 77%, P = 0.05) and radiation therapy (86% vs. 52%, P <

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Järvinen, Kristiina, Petra Pietarinen-Runtti, Kaija Linnainmaa, et al. "Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells." American Journal of Physiology-Lung Cellular and Molecular Physiology 278, no. 4 (2000): L696—L702. http://dx.doi.org/10.1152/ajplung.2000.278.4.l696.

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The development of drug resistance of tumors is multifactorial and still poorly understood. Some cytotoxic drugs generate free radicals, and, therefore, antioxidant enzymes may contribute to drug resistance. We investigated the levels of manganese superoxide dismutase (Mn SOD), its inducibility, and its protective role against tumor necrosis factor-α and cytotoxic drugs (cisplatin, epirubicin, methotrexate, and vindesin) in human pleural mesothelioma (M14K) and pulmonary adenocarcinoma (A549) cells. We also studied other major antioxidant mechanisms in relation to oxidant and drug resistance o

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Quinn, Gillian, Laura Comber, Chris McGuigan, Rose Galvin, and Susan Coote. "Discriminative ability and clinical utility of the Timed Up and Go (TUG) in identifying falls risk in people with multiple sclerosis: a prospective cohort study." Clinical Rehabilitation 33, no. 2 (2018): 317–26. http://dx.doi.org/10.1177/0269215518793481.

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Objective: To investigate discriminative ability and clinical utility of the Timed Up and Go under single- and dual-task conditions between fallers and non-fallers in multiple sclerosis (MS). Design: Prospective cohort study. Setting: Neurology service in a tertiary hospital. Subjects: Participants were 101 people with MS and Expanded Disability Status Scale score of 3–6.5. One participant withdrew after the baseline assessment, and hence the data were analysed for 100 participants. Interventions: No specific intervention. Main Measures: Timed Up and Go and Timed Up and Go-Cognitive. Three-mon

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Wang, A., Y. Ding, and H. Cao. "DOP026 Porphyromonas gingivalis secreted htpG disrupts TLR4/ PAPSS2-mediated mucin sulfation and aggravates ulcerative colitis." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i132. https://doi.org/10.1093/ecco-jcc/jjae190.0065.

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Abstract Background The role of the oral microbiota in the development of IBD and its association with disease severity has been established. However, the specific impact and mechanism of Porphyromonas gingivalis (P.g), a major pathogenic bacteria in the oral cavity, in exacerbating colitis remain unclear. Our objective is to investigate how P.g exacerbates ulcerative colitis. Methods Fecal samples were collected from patients with active ulcerative colitis and compared to those from healthy controls to assess the abundance of P.g. The impact of P.g on colitis and the colonic mucosal barrier w

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Orlowski, Andi, Chris P. Gale, Rachel Ashton, et al. "Clinical and budget impacts of changes in oral anticoagulation prescribing for atrial fibrillation." Heart 107, no. 1 (2020): 47–53. http://dx.doi.org/10.1136/heartjnl-2020-317006.

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ObjectiveTo assess temporal clinical and budget impacts of changes in atrial fibrillation (AF)-related prescribing in England.MethodsData on AF prevalence, AF-related stroke incidence and prescribing for all National Health Service general practices, hospitals and registered patients with hospitalised AF-related stroke in England were obtained from national databases. Stroke care costs were based on published data. We compared changes in oral anticoagulation prescribing (warfarin or direct oral anticoagulants (DOACs)), incidence of hospitalised AF-related stroke, and associated overall and per

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Hcini, Najeh, Véronique Lambert, Olivier Picone, et al. "Causes and consequences of fever in Amazonian pregnant women: A large retrospective study from French Guiana." PLOS Neglected Tropical Diseases 17, no. 10 (2023): e0011721. http://dx.doi.org/10.1371/journal.pntd.0011721.

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Objective The aim of this study was to describe different causes and consequences of fever during pregnancy in Western French Guiana and along the Maroni River. Study design A retrospective single-center study including all patients with a history of documented fever ≥ 38°C during pregnancy at the West French Guiana Hospital for 9 years. Postpartum fever and nosocomial infections were excluded. We focused on medical history and on clinical and biological findings. Causes were characterized as confirmed or uncertain and then classified as preventable or non-preventable. Results A total of 940 p

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Goto, Michihiko, Hyunkeun Cho, James A. Merchant, et al. "Metrics Selection and Risk Adjustment Methods to Benchmark Inpatient Antibiotic Use." JAMA Network Open 8, no. 6 (2025): e2514989. https://doi.org/10.1001/jamanetworkopen.2025.14989.

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ImportanceThe Centers for Disease Control and Prevention offers a standardized antimicrobial administration ratio (SAAR) as an evaluation metric for inpatient antibiotic use through rankings and peer comparisons (ie, benchmarking). However, the SAAR model only accounts for facility- and unit-level factors without considering the hierarchical nature of the health care data, and it does not directly reflect patient-level factors or stewardship efforts to avoid overly broad-spectrum therapy.ObjectiveTo examine the use of antimicrobial use risk adjustment methods and choice of basic metrics (eg, d

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Regierer, A., A. Weiß, M. Bohl-Buehler, et al. "OP0225 DEPRESSIVE SYMPTOMS IN PSA: A CROSS-SECTIONAL ANALYSIS FROM THE NATIONAL GERMAN RABBIT-SPA REGISTRY." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 135.2–136. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2130.

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Background:Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting the musculoskeletal system as well as skin and nails. The prevalence of depression in psoriasis and PsA is high and ranges from 7-40% [1]. Persistent depressive mood may influence disease activity outcome in PsA, especially patient-reported outcomes.Objectives:To assess the correlation of depressive symptoms with PsA-specific outcome parameters.Methods:RABBIT-SpA is a prospective longitudinal cohort study including PsA patients enrolled at start of a new conventional treatment or b/tsDMARD treatment. In regularly

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Mamlouk, Omar, Anastasia Turin, David D'Achiardi, et al. "Clinical characteristics and outcomes of cancer patients with chronic kidney disease and coronavirus disease 2019." Journal of Clinical Oncology 39, no. 15_suppl (2021): e18815-e18815. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e18815.

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e18815 Background: Coronavirus disease 2019 (COVID-19) has been associated with higher risk of acute kidney injury (AKI) and mortality rate in cancer patients. The prevalence of CKD in cancer patients is close to 20-30% however there has been limited data about cancer patients with CKD and COVID-19 infection. The aim of this study is to evaluate the clinical characteristics and outcomes of this patient population at a tertiary cancer center. Methods: All patient data — demographics, labs, comorbidities and outcomes — were aggregated and analyzed in the Syntropy platform, Palantir Foundry (“Fou

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Aringer, M., L. Arnaud, C. Peschken, et al. "POS0731 ASSOCIATION OF PATIENT-REPORTED OUTCOMES WITH TYPE I INTERFERON GENE SIGNATURE FROM THE INTERNATIONAL SYSTEMIC LUPUS ERYTHEMATOSUS PROSPECTIVE OBSERVATIONAL COHORT STUDY (SPOCS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 648–49. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1181.

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BackgroundThe aim of the Systemic Lupus Erythematosus Prospective Observational Cohort Study (SPOCS) is to examine the disease course of patients with systemic lupus erythematosus (SLE) in relation to their type I interferon gene signature (IFNGS) status.1 IFNGS has been associated with SLE disease activity.2ObjectivesTo identify associations between IFNGS status and patient-reported outcomes (PROs) among patients receiving clinical care while enrolled in SPOCS.MethodsThis noninterventional, international, prospective, observational cohort study included adult patients (≥18 years) with moderat

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Diamanti-Kandarakis, Evanthia, Giovanna Spina, Chryssa Kouli, and Ilias Migdalis. "Increased Endothelin-1 Levels in Women with Polycystic Ovary Syndrome and the Beneficial Effect of Metformin Therapy." Journal of Clinical Endocrinology & Metabolism 86, no. 10 (2001): 4666–73. http://dx.doi.org/10.1210/jcem.86.10.7904.

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Women with polycystic ovary syndrome who present with hyperandrogenemia, hyperinsulinemia, and insulin resistance appear to be at high risk of cardiovascular disease. Elevated levels of endothelin-1, a marker of vasculopathy, have been reported in insulin-resistant subjects with endothelial dysfunction. Male gender also seems to be an aggravating factor for cardiovascular disease. In this study we investigated endothelin-1 levels in women with polycystic ovary syndrome, and we evaluated the effect of an insulin sensitizer, metformin, on endothelin-1 levels. Plasma endothelin-1 levels were meas

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Dr, Abdul Sallam Sajid Dr Muhammad Usman Hasan Dr Ghulam Ali Hasnan. "STUDY TO KNOW THE PREVALENCE OF URINARY TRACT INFECTIONS IN TYPE II DIABETIC PATIENTS TAKING DAPAGLIFLOZIN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 11465–72. https://doi.org/10.5281/zenodo.3237802.

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<strong><em>Objective:</em></strong><em> In type 2 diabetes, the most common complication is Urinary tract infection. The most common causing factors are glucosuria, treatment with sodium glucose cotransporter 2 inhibitors (SGLT2). Dapagliflozin is a research proved SGLT2 inhibitor with proven controls over glycemia in patients of diabetes mellitus. Dapagliflozin data from several safety trials were checked to prove the asoociation between urinary tract infection and glycosuria.</em> <strong><em>Study Design: </em></strong><em>A Randomized Control trial.</em> <strong><em>Place and Duration: </

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Porto, Ana Paula Matos, Icaro Boszczowski, Ann Versporten, et al. "Point Prevalence Surveys and Customized Interventions Are Good Strategies to Improve Antimicrobial Use: The Brazilian Experience." Infection Control & Hospital Epidemiology 41, S1 (2020): s523. http://dx.doi.org/10.1017/ice.2020.1207.

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Background: Although antimicrobial stewardship is recommended by Brazilian government, data regarding prescription practices in the country are scarce. Objective: To describe the impact of 2 point-prevalence surveys and customized interventions on antimicrobial consumption among 8 hospitals in 3 regions of Brazil. Method: In 2017 and 2018, 8 tertiary-care Brazilian hospitals conducted the Global Point Prevalence Survey of Antimicrobial Consumption and Resistance (Global-PPS). All enrolled hospitals were provided the 2017 results. The group discussed intervention strategies by WhatsApp and e-ma

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Şan, S., Ö. Özdemir Işik, A. Yazici, and A. Cefle. "AB0362 DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF BEHCET’S DİSEASE PATIENTS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1206.2–1207. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1543.

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Background:Behcet’s Disease (BD) is a systemic variable vessel vasculitis that involves the skin, mucosa, joints, eyes, arteries, veins, nervous system and the gastrointestinal system.Objectives:In this study we aimed to present variety of involvements in patients who were followed up in our outpatient clinic with a diagnosis of BD.Methods:Data of 394 patients diagnosed with BD between 2000-2020 were retrospectively reviewed clinical, demographic characteristics and systemic involvements.Results:In our study 43.7% of BD patients were female, 56.3% were male and the mean age was 40±11years, dis

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Remy, Katya, Chase Alston, Elyse Gonzales, et al. "Targeted Reinnervation During Gender-Affirming Mastectomy and Restoration of Sensation." JAMA Network Open 7, no. 11 (2024): e2446782. http://dx.doi.org/10.1001/jamanetworkopen.2024.46782.

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ImportanceDuring gender-affirming mastectomy, nerves are transected, resulting in sensory loss. Nerve preservation using targeted nipple-areola complex (NAC) reinnervation (TNR) may restore sensation.ObjectiveTo determine the quantitative and patient-reported sensory outcomes of TNR.Design, Setting, and ParticipantsProspective matched cohort study of patients undergoing gender-affirming mastectomy from August 2021 to December 2022 at Weill Cornell Medicine and Massachusetts General Hospital. Data were analyzed from January to March 2023.ExposurePatients who underwent TNR and matched patients w

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Feelders, Richard, Mônica Gadelha, Marie Bex, et al. "PMON162 Osilodrostat Provides Sustained Clinical Benefits and Improves Health-Related Quality of Life in Patients with Cushing's Disease: Results from the Phase III LINC 4 Study." Journal of the Endocrine Society 6, Supplement_1 (2022): A546. http://dx.doi.org/10.1210/jendso/bvac150.1135.

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Abstract Background Cushing's disease (CD) is a serious disorder associated with increased cardiovascular morbidity and mortality, and reduced patient quality of life (QoL), because of hypercortisolism. We report long-term effects of osilodrostat, a potent 11β-hydroxylase inhibitor, on cardiovascular/metabolic-related risk factors, physical features of hypercortisolism and QoL in CD patients following the core and extension phases of the LINC 4 study (NCT02697734). Methods LINC 4 comprised a 12-week (W), randomized, double-blind, placebo-controlled period, 36W of open-label osilodrostat, and a

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Kwon, H., S. Lee, S. Oh, S. Kim, and H. Kim. "Phase II study of mFOLFOX-4 followed by mFOLFIRI in advanced gastric cancer." Journal of Clinical Oncology 27, no. 15_suppl (2009): e15546-e15546. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e15546.

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e15546 Background: FOLFOX followed by FOLFIRI regimen has been commonly used in colorectal cancer. This combination has also been evaluated in a number of phase II studies in the first- and second-line treatment setting of advanced gastric cancer. We have evaluated the efficacy and toxicity of modified FOLFOX-4 followed by modified FOLFIRI regimens in advanced gastric cancer patients. Methods: Previously untreated patients with advanced or recurrent gastric cancer were enrolled. As first-line therapy, patients received modified FOLFOX-4, bolus ldLV 50mg followed by a 5-FU bolus 400mg/m2 and 22

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Czuczman, Myron S., Christos Emmanouilides, Mohamed Darif, et al. "Analysis of the Incidence of Treatment-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Registration and Compassionate-Use Trials of Ibritumomab Tiuxetan Radioimmunotherapy (RIT)." Blood 108, no. 11 (2006): 485. http://dx.doi.org/10.1182/blood.v108.11.485.485.

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Abstract Radioimmunotherapy (RIT) is a therapeutic modality indicated for the treatment of patients with relapsed or refractory low-grade, follicular, or transformed non-Hodgkin’s lymphoma (NHL), where the mechanism of action involves the intrinsic activity of the monoclonal antibody and the cytotoxic effects of radiation. The primary toxicity is a late-occurring, transient, and reversible myelosuppression. Because of concerns regarding the long-term effects of radiation on the bone marrow, we investigated the incidence of treatment-related myelodysplastic syndrome (t-MDS) and treatment-relate

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Palomares-Pérez, Martín, Manuel Bravo-Nuñez, and Hugo C. Arredondo-Bernal. "LIBERACIÓN DE Chrysoperla externa (Hagen) (Neuroptera: Chrysopidae) Y MANEJO PARA EL CONTROL DE Melanaphis sacchari (Zehntner) (Hemiptera: Aphididae) EN CULTIVO DE SORGO." Agrociencia 54, no. 3 (2020): 435–44. http://dx.doi.org/10.47163/agrociencia.v54i3.1917.

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Melanaphis sacchari es una plaga de reciente introducción en México y puede causar hasta 100% de pérdidas al cultivo de sorgo (Sorghum vulgare). La estrategia del manejo integrado de este pulgón incluye el uso de enemigos naturales, por tal motivo, para colaborar en la problemática ocasionada por este insecto, se planteó el objetivo de evaluar el efecto de la liberación de Chrysoperla externa sobre la población de M. sacchari en el cultivo de sorgo en ambiente natural de cultivo e invernadero. La hipótesis es que la densidad poblacional de M. sacchari y el número de plantas de sorgo infestadas

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RASUL, ZAHID, NASIM AHMAD, and MUHAMMAD ANZAR. "Changes in Motion Characteristics, Plasma Membrane Integrity, and Acrosome Morphology During Cryopreservation of Buffalo Spermatozoa." Journal of Andrology 22, no. 2 (2001): 278–83. http://dx.doi.org/10.1002/j.1939-4640.2001.tb02181.x.

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ABSTRACT: Motion characteristics, plasma membrane integrity, and acrosome morphology of buffalo spermatozoa after different stages of cryopreservation (ie, dilution, cooling to 4°C, equilibration at 4°C, and freezing and thawing) were examined. Semen ejaculates from 4 buffalo bulls were pooled (n = 5), diluted in triscitric acid extender, cooled to 4°C over 2 hours, equilibrated at 4°C for 4 hours, dispensed into 0.5‐mL straws, and frozen in a programmable cell freezer before plunging into liquid nitrogen. Frozen semen was thawed at 37°C for 15 seconds. After completion of each stage, sperm mo

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Dias, L. P., P. M. S. Rosa, A. J. R. Camargo, R. V. Serapião, L. S. A. Camargo, and C. S. Oliveira. "134 FOLLICULAR DYNAMICS OF Gyr AND HOLSTEIN OOCYTE DONORS KEPT UNDER TROPICAL CONDITIONS." Reproduction, Fertility and Development 28, no. 2 (2016): 197. http://dx.doi.org/10.1071/rdv28n2ab134.

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Bovine in vitro production is highly relevant for dairy systems in Brazil, and the main breeds used as oocyte donors are Gyr (G) and Holstein (H). This study aimed to evaluate the ovarian follicular dynamics of G and H oocyte donors kept under tropical conditions to detect differences that could guide improvement of follicular wave synchronization protocols for ovum pickup. Fourteen cyclic cows (6 H and 8 G), assessed twice each (after a 14-day interval), had their oestrus cycle synchronized by the use of 1.0 g of progesterone via intravaginal device (Ourofino, Brazil) and administration of 2

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Kressin, Nancy R., Jolie B. Wormwood, Tracy A. Battaglia, Priscilla J. Slanetz, and Christine M. Gunn. "Sociodemographic Variations in Women’s Reports of Discussions With Clinicians About Breast Density." JAMA Network Open 6, no. 11 (2023): e2344850. http://dx.doi.org/10.1001/jamanetworkopen.2023.44850.

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ImportanceBreast density notifications advise women to discuss breast density with their clinicians, yet little is known about such discussions.ObjectivesTo examine the content of women’s reports of breast density discussions with clinicians and identify variations by women’s sociodemographic characteristics (age, income, state legislation status, race and ethnicity, and literacy level).Design, Setting, and ParticipantsThis US nationwide, population-based, random-digit dial telephone survey study was conducted from July 1, 2019, to April 30, 2020, among 2306 women aged 40 to 76 years with no h

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