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Journal articles on the topic '796.952 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Noble, Fiona. "The Cinema of Lucrecia Martel, Deborah Martin (2016)." Studies in Spanish & Latin American Cinemas 19, no. 2 (2022): 259–62. http://dx.doi.org/10.1386/slac_00089_5.

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Review of: The Cinema of Lucrecia Martel, Deborah Martin (2016) Manchester: Manchester University Press, 160 pp., ISBN 978-0-71909-034-9, h/bk, £80.00 ISBN 978-1-52613-942-9, p/bk, £20.00 ISBN 978-1-78499-792-2, e-book, £18.24

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Comfort, Paul, Christopher Thomas, Thomas Dos’Santos, Paul A. Jones, Timothy J. Suchomel, and John J. McMahon. "Comparison of Methods of Calculating Dynamic Strength Index." International Journal of Sports Physiology and Performance 13, no. 3 (2018): 320–25. http://dx.doi.org/10.1123/ijspp.2017-0255.

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Purpose: To determine the reliability and variability of the Dynamic Strength Index (DSI) calculated from squat-jump (SJ) vs countermovement-jump (CMJ) peak force (PF) and to compare DSI values between methods. Methods: Male youth soccer and rugby league players (N = 27; age 17.2 ± 0.7 y, height 173.9 ± 5.7 cm, body mass 71.1 ± 7.2 kg) performed 3 trials of the SJ, CMJ, and isometric midthigh pull (IMTP) on 2 separate days. DSI was calculated by dividing the PF during each jump by the IMTP PF. Results: DSI-SJ exhibited moderate (intraclass correlation coefficient [ICC] = .419) within-session r

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Bowmaker, Graham A., Frances M. M. Hannaway, Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. IV Bismuth(III) Halide/N,N′-Bidentate Ligand (1 : 1) Systems." Australian Journal of Chemistry 51, no. 4 (1998): 325. http://dx.doi.org/10.1071/c97039.

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Room-temperature single-crystal X-ray studies are recorded for a number of adducts of BiX3 and N,N′-bidentate ligand (2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen)), devoid of coordinated solvent. BiBr3/bpy/MeCN (1 : 1 : 1) is triclinic P-1, a 12·129(2), b 9·955(4), c 7·748(1) Å, α 73·14(2), β 77·34(1), γ 69·79(2)°, Z = 2; conventional R on |F| was 0·036 for No 2252 independent ‘observed’ (I > 3σ(I)) reflections. The phen analogue is isomorphous, a 11·586(3), b 10·839(6), c 7·769(10) Å, α 73·70(7), β 76·67(7), γ 70·34(4)°, Z = 2, R 0·042 for No 800. BiI3/bpy (1 : 1) is triclinic, P-1,

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Wieser, M. E. "Atomic weights of the elements 2005 (IUPAC Technical Report)." Pure and Applied Chemistry 78, no. 11 (2006): 2051–66. http://dx.doi.org/10.1351/pac200678112051.

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The latest evaluation of atomic weight determinations and other cognate data has warranted 16 changes for the standard atomic weights of the elements, Ar(E), from those published previously in the 2001 Table of Atomic Weights. The revised standard atomic weights are as follows: Ar(Al) = 26.981 5386(8), Ar(Bi) = 208.980 40(1), Ar(Cs) = 132.905 4519(2), Ar(Co) = 58.933 195(5), Ar(Au) = 196.966 569(4), Ar(La) = 138.905 47(7), Ar(Mn) = 54.938 045(5), Ar(Nd) = 144.242(3), Ar(P) = 30.973 762(2), Ar(Pt) = 195.084(9), Ar(Sm) = 150.36(2), Ar(Sc) = 44.955 912(6), Ar(Na) = 22.989 769 28(2), Ar(Ta) = 180.

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Brimble, Margaret A., Andrew Johnston, Trevor W. Hambley, and Peter Turner. "Crystal Structures of (3S*,4S*,5S*,6S*)-3,4-Epoxy- 1,7-dioxaspiro[5.5]undecan-5-ol, (3R*,5S*,6S*)-1,7- Dioxaspiro[5.5]undecane-3,5-diyl Diacetate and (4S*,5S*,6S*)-1,7-Dioxaspiro[5.5]undecane-4,5-diol." Australian Journal of Chemistry 50, no. 2 (1997): 123. http://dx.doi.org/10.1071/c96186.

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The structures of (3S*,4S*,5S*,6S*)-3,4-epoxy-1,7-dioxaspiro[5.5]undecan-5-ol (2), (3R*,5S*,6S*)-1,7- dioxaspiro[5.5]undecane-3,5-diyl diacetate (4) and (4S*,5S*,6S*)-1,7-dioxaspiro[5.5]undecane-4,5-diol (5) have been determined by X-ray crystallography. The unsubstituted tetrahydropyran ring in (2) adopts an axial position with respect to the epoxy-substituted ring and the hydroxy group at C5 is syn to the epoxide group. Intermolecular hydrogen bonding is observed between the C5 hydroxy group and O1. The two six-membered rings in (4) adopt chair conformations and the two acetate groups adopt

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Castellano, Daniel E., Arjun Vasant Balar, Peter H. O'Donnell, et al. "Post hoc analysis of the efficacy of pembrolizumab retreatment after progression of advanced urothelial carcinoma (UC) in KEYNOTE-045 and KEYNOTE-052." Journal of Clinical Oncology 40, no. 6_suppl (2022): 512. http://dx.doi.org/10.1200/jco.2022.40.6_suppl.512.

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512 Background: Pembrolizumab (pembro) has shown efficacy in advanced/unresectable and metastatic UC (mUC). There is interest in determining whether pts should be treated subsequently with checkpoint inhibitors such as anti–PD-1 therapy if mUC responds then later progresses. Pembro retreatment after disease progression has shown efficacy in melanoma and NSCLC. This post hoc exploratory analysis investigated the efficacy of pembro retreatment for pts with advanced UC or mUC enrolled in KEYNOTE-045 and KEYNOTE-052 with a best overall response (BOR) of SD or better and whose disease progressed af

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Steen, R. W. J. "A comparison of soya-bean meal, fish meal and maize gluten feed as protein sources for calves offered grass silage ad libitum." Animal Science 54, no. 3 (1992): 333–39. http://dx.doi.org/10.1017/s000335610002078x.

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AbstractTwo experiments were carried out to evaluate extracted soya-bean meal, fish meal and maize gluten feed as protein supplements for calves offered grass silage ad libitum. The five treatments used in experiment 1 consisted of 1·4 kg per head daily of concentrate dry matter (DM) consisting of (g/kg) 50 molasses and 25 minerals and vitamins plus (1) 925 barley (B), (2) 700 B and 225 extracted soya-bean meal (SBM), (3) 785 B and 140 fish meal (FM), (4) 925 maize gluten feed (MGF) and (5) 2·25 kg DM per head daily of concentrate (1). Those used in experiment 2 consisted of 1·4 kg per head da

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Pirogov, Yuriy I., Galina M. Butina, Roman A. Morozov, et al. "Our experience of bromfenac-containing NSAID use in patients after cataract surgery." Ophthalmology journal 9, no. 2 (2016): 53–56. http://dx.doi.org/10.17816/ov9253-56.

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Postoperative cystoid macular edema is an autoimmune reaction due to the blood-retinal barrier breakdown occurring at anterior segment inflammation. Aim: To analyze the effectiveness of various anti-inflammatory therapeutic schemes used in cataract surgery. Materials and methods. Phacoemulsification using similar consumables had been performed in 792 patients (932 eyes). They were divided into three groups: 1st group included patients receiving 1 to 3 dexamethasone (0.3 ml) and mesatone (0.1 ml) injections and Tobradex eye drops starting with 5 times a day for 4-5 weeks and then tapering (356

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Nolan, Annette L., Christine C. Allen, Robert C. Burns, Donald C. Craig, and Geoffrey A. Lawrance. "Monomeric and Dimeric Cobalt(III) Polyoxomolybdates: Crystal Structures and Cyclic Voltammetry of Na3 [H6CoMo6O24].8H2O and K6 [H4Co2Mo10O38].7H2O." Australian Journal of Chemistry 51, no. 9 (1998): 825. http://dx.doi.org/10.1071/c97218.

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The crystal structures of Na3 [H6CoMo6O24].8H2O and K6 [H4Co2Mo10O38].7H2O have been determined by X-ray diffraction. The monomer, Na3 [H6CoMo6O24].8H2O, is triclinic, space group P-1, a 6·451(1), b 10·866(2), c 10·922(2) Å, α 109·20(1), β 106·90(1), γ 95·43(1)°, V 676·3(2) Å3, Z 1, and the structure was solved to an R1 value of 0·0243 (wR2 0·0784) for 3761 independent observed reflections. The anion exhibits the well known Anderson structure with six octahedral MoO6 edge-sharing units surrounding the central ‘CoO6’ octahedron, with all metals in a common plane. The dimer, K6 [H4Co2Mo10O38].7H

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Nguyen, Paul L., Alphonse G. Taghian, Matthew S. Katz, et al. "Breast Cancer Subtype Approximated by Estrogen Receptor, Progesterone Receptor, and HER-2 Is Associated With Local and Distant Recurrence After Breast-Conserving Therapy." Journal of Clinical Oncology 26, no. 14 (2008): 2373–78. http://dx.doi.org/10.1200/jco.2007.14.4287.

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Purpose To determine whether breast cancer subtype is associated with outcome after breast-conserving therapy (BCT) consisting of lumpectomy and radiation therapy. Patients and Methods We studied 793 consecutive patients with invasive breast cancer who received BCT from July 1998 to December 2001. Among them, 97% had pathologically negative margins of resection, and 90% received adjuvant systemic therapy. No patient received adjuvant trastuzumab. Receptor status was used to approximate subtype: estrogen receptor (ER) or progesterone receptor (PR) positive and human epidermal growth factor rece

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Ezeh, Osita Kingsley. "Trends and population-attributable risk estimates for predictors of early neonatal mortality in Nigeria, 2003–2013: a cross-sectional analysis." BMJ Open 7, no. 5 (2017): e013350. http://dx.doi.org/10.1136/bmjopen-2016-013350.

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ObjectivesTo assess trends in early neonatal mortality (ENM) and population-attributable risk (PAR) estimates for predictors of ENM in Nigeria.Design, setting and participantsA cross-sectional data on 63 844 singleton live births within the preceding 5 years from the 2003, 2008 and 2013 Nigeria Demographic and Health Surveys were used. Adjusted PARs were used to estimate the number of early neonatal deaths attributable to each predictor in the final multivariable Cox regression model.Main outcome measuresENM, defined as the death of a live-born singleton between birth and 6 days of life.Result

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Alexeeff, Stacey E., Kamala Deosaransingh, Stephen Van Den Eeden, Joel Schwartz, Noelle S. Liao, and Stephen Sidney. "Association of Long-term Exposure to Particulate Air Pollution With Cardiovascular Events in California." JAMA Network Open 6, no. 2 (2023): e230561. http://dx.doi.org/10.1001/jamanetworkopen.2023.0561.

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ImportanceLong-term exposure to fine particulate air pollution (PM2.5) is a known risk factor for cardiovascular events, but controversy remains as to whether the current National Ambient Air Quality Standard (12 μg/m3 for 1-year mean PM2.5) is sufficiently protective.ObjectiveTo evaluate the associations between long-term fine particulate air pollution and cardiovascular events using electronic health record and geocoded address data.Design, Setting, and ParticipantsThis retrospective cohort study included adults in the Kaiser Permanente Northern California integrated health care system durin

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Demetri, George D., Jason J. Luke, Antoine Hollebecque, et al. "First-in-human phase 1 study of ABBV-085, an antibody-drug conjugate (ADC) targeting LRRC15, in sarcomas and other advanced solid tumors." Journal of Clinical Oncology 37, no. 15_suppl (2019): 3004. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.3004.

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3004 Background: ABBV-085 is an ADC (conjugated to monomethyl auristatin E, drug:antibody ratio of 2:1) directed against leucine-rich repeat containing 15 (LRRC15), a type 1 transmembrane protein highly expressed on the surface of sarcomas and cancer-associated fibroblasts in stroma of many other cancers. ABBV-085 induced antitumor activity in both in vitro and xenograft models of sarcoma. This phase 1, first-in-human, 2-part study assessed the safety/tolerability of ABBV-085 in patients (pts) with advanced solid tumors (NCT02565758). Methods: Eligible pts (≥18 yr; advanced solid tumors) recei

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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics

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Cayuela, Jean-Michel, Paola Ballerini, Marina Romeo, et al. "Evaluation of Minimal Residual Disease (MRD) by Quantification of TEL-AML1 Transcripts Is a Powerful Prognostic Tool in Children with T(12;21) Positive Acute Lymphoblastic Leukemia (ALL)." Blood 104, no. 11 (2004): 322. http://dx.doi.org/10.1182/blood.v104.11.322.322.

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Abstract TEL-AML1 fusion transcripts are found in 25% of children with B-cell precursor ALL (BCP-ALL). From June 1993 to December 1999, 1195 children with BCP-ALL were included in the FRALLE 93 protocol. Out of these, 792 were evaluated for TEL-AML1 transcript expression. There is no difference in terms of initial features, DFS, EFS, survival between evaluated (792) and non evaluated (403) patients. Out of the 792 pts, 191 (24%) expressed TEL-AML1 transcripts at diagnosis. To assess the potential prognostic value of TEL-AML1 transcripts quantification, we have retrospectively analysed follow u

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Moltó, A., A. Ajrouche, D. Tran, et al. "POS0305 CONTINUING TNFI AFTER PREGNANCY DIAGNOSIS IN WOMEN WITH CHRONIC RHEUMATIC INFLAMMATORY DISEASES IS NOT ASSOCIATED WITH WORSE OBSTETRICAL OR INFECTIOUS OUTCOMES: THE RESULTS OF AN EMULATED TARGET TRIAL." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 395.2–396. http://dx.doi.org/10.1136/annrheumdis-2023-eular.3787.

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BackgroundContinuation of biologics during pregnancy in patients with chronic inflammatory diseases during pregnancy is still a difficult medical decision. Many women with chronic rheumatic inflammatory diseases (CRID) decide to stop tumor necrosis factor inhibitors (TNFi) treatment once pregnancy is confirmed to avoid potential adverse fetal events but taking the risk of inflammatory flare.ObjectivesTo compare in real life settings the pregnancy outcomes of two treatment strategies among women with CRID: to continue TNFi vs. stop TNFi upon pregnancy diagnosis.Methodsthe French nationwide heal

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Enache, L., C. Popescu, and C. Codreanu. "AB1333 ULTRASOUND FINDINGS IN NORMAL ANKLES – ULTRASOUND-MRI COMPARISON." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1773.1–1773. http://dx.doi.org/10.1136/annrheumdis-2022-eular.790.

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BackgroundAlthough in recent years efforts have been made to standardize the protocols of ultrasound acquisition for each anatomical region, as well as the definitions and quantification of pathological findings, there is still an unanswered question: what should an ankle joint look like in a healthy subject?ObjectivesThe study aims to describe ultrasound changes in the ankles of healthy subjects and to compare the ultrasound method with MRI.MethodsThe study included healthy volunteering adults, without any ankle symptoms or local pathological medical history. The right ankle was examined clin

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Long, Elliot, Meredith L. Borland, Shane George, et al. "External Validation of the Phoenix Sepsis Score in Children With Suspected Community-Acquired Sepsis." JAMA Network Open 8, no. 3 (2025): e251412. https://doi.org/10.1001/jamanetworkopen.2025.1412.

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ImportanceThe novel Phoenix Sepsis Score and sepsis criteria were derived and validated using a multicountry dataset and proposed as a new definition for sepsis in children.ObjectiveTo externally validate the Phoenix Sepsis Score and sepsis criteria in a cohort of children hospitalized with suspected community-acquired sepsis.Design, Setting, and ParticipantsThis diagnostic study used data from the multicenter, multicountry Sepsis Epidemiology in Australian and New Zealand Emergency Departments (SENTINEL) study, collected from 2021 to 2023 and including 90-day follow-up. Children admitted to t

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Johnston, Kenton J., Michelle Hendricks, Megha Dabas, et al. "Nationwide Availability of and Enrollment in Medicare and Medicaid Dual-Eligible Special Needs Plans With Exclusively Aligned Enrollment." JAMA Health Forum 5, no. 10 (2024): e243546. http://dx.doi.org/10.1001/jamahealthforum.2024.3546.

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ImportanceIn 2021, the Centers for Medicare &amp;amp; Medicaid Services designated a new category of dual-eligible special needs plans (D-SNPs) with exclusively aligned enrollment (receive Medicare and Medicaid benefits through the same plan or affiliated plans within the same organization).ObjectiveTo assess the availability of and enrollment in D-SNPs with exclusively aligned enrollment and to compare the characteristics of beneficiaries enrolled in D-SNPs with exclusively aligned enrollment available vs beneficiaries without such enrollment available.Design, Setting, and ParticipantsFul

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Davis, J. M., S. Achenbach, C. Arment, et al. "POS0476 QUANTIFICATION OF REFERRAL BIAS IN PATIENT- AND CLINICIAN-REPORTED MEASURES OF RHEUMATOID ARTHRITIS SEVERITY BY GEOGRAPHIC DISTANCE FROM AN ACADEMIC RHEUMATOLOGY CENTER." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 498.2–499. http://dx.doi.org/10.1136/annrheumdis-2023-eular.4051.

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BackgroundSystematic bias to greater severity of rheumatoid arthritis (RA) is often presumed to exist in patients referred for evaluation at academic centers. However, the magnitude of this potential bias has not been quantified to our knowledge.ObjectivesThe objective was to test the hypothesis that patients in a referral population have greater RA severity based on both patient- and clinician-reported measures than local patients.MethodsThis study included eligible patients with RA who attended an in-person or virtual appointment in the outpatient rheumatology clinic at an academic center be

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Kilic, Deniz, Anika Förster, Erik Mertens, H. Burkhard Dick, and Suphi Taneri. "Rotational Stability After Implantation of Two Different Phakic Toric Intraocular Lenses." Journal of Refractive Surgery 39, no. 7 (2023): 463–72. http://dx.doi.org/10.3928/1081597x-20230512-03.

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Purpose: To compare clinical outcomes and rotational stability of the toric implantable Collamer lens (TICL) and toric implantable phakic contact lens (TIPCL). Methods: Charts were reviewed from January 2011 to January 2023 to identify all TICLs and TIPCLs implanted by a single surgeon. Implant size was generally chosen according to the manufacturer's recommendation, but 15 TIPCLs 0.25 mm larger than recommended to increase vaulting were included. Results: Eighty-four TICLs and 98 TIPCLs were identified and yielded excellent refractive and visual results in eyes with high myopic astigmatism at

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Susilawati, Sella. "Penggunaan Kohesi Gramatikal dan Kohesi Leksikal pada Kumpulan Cerpen Surat Kecil untuk Ayah Karya Boy Candra." Diskursus: Jurnal Pendidikan Bahasa Indonesia 4, no. 2 (2021): 189. http://dx.doi.org/10.30998/diskursus.v4i2.9820.

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<p>Tujuan dari penelitian ini adalah: 1) Untuk mengetahui penggunaan kohesi gramatikal yang terdapat dalam kumpulan cerpen <em>Surat Kecil untuk Ayah </em>karya Boy Candra. 2) Untuk mengetahui penggunaan kohesi leksikal yang terdapat dalam kumpulan cerpen <em>Surat Kecil untuk Ayah </em>karya Boy Candra. 3) Untuk mengetahui perbandingan pengunaan kohesi gramatikal dengan kohesi leksikal yang terdapat dalam kumpulan cerpen <em>Surat Kecil untuk Ayah </em>karya Boy Candra. Metode yang digunakan dalam penelitian ini, yaitu metode deskriptif kualitatif. Ad

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Vrancianu, C., I. Conea, A. Boca, et al. "FRI0551 PERFORMANCE OF THE 2019 AMERICAN COLLEGE OF RHEUMATOLOGY/EUROPEAN LEAGUE AGAINST RHEUMATISM SYSTEMIC LUPUS ERYTHEMATOSUS CLASSIFICATION CRITERIA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 877.2–877. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3786.

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Background:Systemic lupus erythematosus (SLE) is a heterogenous autoimmune disease, with increased morbidity and mortality, often diagnosed in advanced stages. The recently published 2019 American College Of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for SLE are weighted, hierarchically clustered criteria developed to increase reliability and the identification of early SLE.Objectives:To compare the sensitivity and specificity of the 2019 ACR/EULAR criteria with the 2012 SLICC criteria in a large single-centre cohort of patients with SLE, diagnosed acco

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Yoshida, Naohisa, Yuji Naito, Ritsu Yasuda, et al. "The efficacy of the pocket-creation method for cases with severe fibrosis in colorectal endoscopic submucosal dissection." Endoscopy International Open 06, no. 08 (2018): E975—E983. http://dx.doi.org/10.1055/a-0593-5818.

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Abstract Background and study aims Severe fibrosis poses a challenge in colorectal endoscopic submucosal dissection (ESD). Recently, the pocket-creation method (PCM) has been developed for overcoming various difficulties of ESD. A specific tapered hood is used for adequate traction in the PCM, and endoscopic operability becomes stable in the pocket. In this study, we investigated the efficacy of the PCM in ESD for cases with severe fibrosis. Patients and methods We retrospectively reviewed 1000 consecutive colorectal ESD cases (April 2006 to January 2017). Since 2016, the PCM was performed in

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Dias, L. P., P. M. S. Rosa, A. J. R. Camargo, R. V. Serapião, L. S. A. Camargo, and C. S. Oliveira. "134 FOLLICULAR DYNAMICS OF Gyr AND HOLSTEIN OOCYTE DONORS KEPT UNDER TROPICAL CONDITIONS." Reproduction, Fertility and Development 28, no. 2 (2016): 197. http://dx.doi.org/10.1071/rdv28n2ab134.

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Bovine in vitro production is highly relevant for dairy systems in Brazil, and the main breeds used as oocyte donors are Gyr (G) and Holstein (H). This study aimed to evaluate the ovarian follicular dynamics of G and H oocyte donors kept under tropical conditions to detect differences that could guide improvement of follicular wave synchronization protocols for ovum pickup. Fourteen cyclic cows (6 H and 8 G), assessed twice each (after a 14-day interval), had their oestrus cycle synchronized by the use of 1.0 g of progesterone via intravaginal device (Ourofino, Brazil) and administration of 2

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Linehan, C. J., D. P. Armstrong, P. T. Doyle, and F. Johnson. "A survey of water use efficiency on irrigated dairy farms in northern Victoria." Australian Journal of Experimental Agriculture 44, no. 2 (2004): 131. http://dx.doi.org/10.1071/ea02234.

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Water use efficiency (WUE) in irrigated dairy systems has been defined, in this paper, as the amount of milk (kg milk fat plus protein) produced from pasture per megalitre of water (irrigation plus effective rainfall). A�farm survey was conducted for the 1997–98 and 1998–99 seasons in the Goulburn Irrigation System (GIS) and Murray Irrigation System (MIS) when the irrigation water allocated to irrigators in the GIS was low (100–120% of water right compared with the MIS which was 130 and 200% of water right). These data were analysed in conjunction with information collected on the same farms i

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Desai, Nihar, Tommy Alfaro-Moya, Eshrak Al-Shaibani, et al. "Long-term outcomes of patients surviving beyond 2 years post–allogeneic stem cell transplantation." Journal of Clinical Oncology 43, no. 16_suppl (2025): 6508. https://doi.org/10.1200/jco.2025.43.16_suppl.6508.

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6508 Background: Advances in hematopoietic stem cell transplantation (HSCT) have been driven by progress in supportive care, conditioning regimens, and graft-versus-host disease (GvHD) prophylaxis. Post-transplant morbidity and mortality are most pronounced in the first two years after HCT. Long-term outcomes have been previously described in a CIBMTR study, which reported a 10-year survival of 85% for those who survived the first two years. Post-transplant cyclophosphamide (PTCy) has revolutionized transplant outcomes. However, its impact on long-term survival remains unclear. Methods: We inc

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Schulman, Sam, Henry Eriksson, Samuel Z. Goldhaber, et al. "Influence of Thrombophilia on the Efficacy of Dabigatran Versus Warfarin for the Extended Treatment of Acute Venous Thromboembolism in RE-MEDY™." Blood 124, no. 21 (2014): 1544. http://dx.doi.org/10.1182/blood.v124.21.1544.1544.

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Abstract Background: Dabigatran etexilate (DE) was noninferior to warfarin for the prevention of recurrent venous thromboembolism (VTE), with a lower risk of bleeding, when administered as extended treatment for VTE in the RE-MEDY™ study (in which we evaluated long-term extension of treatment with dabigatran compared with warfarin). Objectives: Thrombophilia is a major risk factor for VTE recurrence. Therefore, we performed a post-hocsubgroup analysis on data from RE-MEDY™ to investigate the efficacy of DE versus warfarin in patients with and without thrombophilia (congenital or acquired) at b

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Vazquez, J. M., E. A. Martinez, I. Parrilla, et al. "352 IMPROVING THE EFFICIENCY OF LAPAROSCOPIC INTRAOVIDUCTAL INSEMINATION WITH SEX-SORTED BOAR SPERMATOZOA." Reproduction, Fertility and Development 18, no. 2 (2006): 283. http://dx.doi.org/10.1071/rdv18n2ab352.

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The insemination of a low number of sex-sorted spermatozoa is a critical issue that must be solved in order to enable the commercial application of this technology in pigs. A new procedure for laparoscopic intraoviductal insemination in sows has recently been reported (Vazquez et al. 2005 Reprod. Dom. Animals 40, 375 abst.). To improve the efficiency of this technique, this experiment was designed to determine the influence of insemination time, relative to the time of ovulation, on the number and quality of zygotes recovered after laparoscopic insemination of sows with sex-sorted spermatozoa.

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Feelders, Richard, Mônica Gadelha, Marie Bex, et al. "PMON162 Osilodrostat Provides Sustained Clinical Benefits and Improves Health-Related Quality of Life in Patients with Cushing's Disease: Results from the Phase III LINC 4 Study." Journal of the Endocrine Society 6, Supplement_1 (2022): A546. http://dx.doi.org/10.1210/jendso/bvac150.1135.

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Abstract Background Cushing's disease (CD) is a serious disorder associated with increased cardiovascular morbidity and mortality, and reduced patient quality of life (QoL), because of hypercortisolism. We report long-term effects of osilodrostat, a potent 11β-hydroxylase inhibitor, on cardiovascular/metabolic-related risk factors, physical features of hypercortisolism and QoL in CD patients following the core and extension phases of the LINC 4 study (NCT02697734). Methods LINC 4 comprised a 12-week (W), randomized, double-blind, placebo-controlled period, 36W of open-label osilodrostat, and a

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Hanzis, Christina, Zachary Hunter, Robert Manning, et al. "Associated Malignancies Among Patients and Kin with Waldenstrom's Macroglobulinemia." Blood 116, no. 21 (2010): 4159. http://dx.doi.org/10.1182/blood.v116.21.4159.4159.

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Abstract Abstract 4159 Waldenstrom's macroglobulinemia (WM) is a B-cell malignancy characterized as an IgM secreting lymphoplasmacytic lymphoma. Familial predisposition is common in WM. Studies to date by us and others have revealed three identifiable clinical subtypes for WM predisposition: * Sporadic; proband has WM, but there is an absence of WM or other B-cell disorders in other family members; * Familial, Mixed B-cell Disorders Subtype; proband has WM, and various B-cell disorders are manifested by other family members. * Familial, WM Only Subtype; proband has WM, and only WM is present i

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Curtis, J., I. Mcinnes, P. Rahman, et al. "AB0756 GUSELKUMAB IMPROVED WORK PRODUCTIVITY AND DAILY ACTIVITY IN PATIENTS WITH PSORIATIC ARTHRITIS: RESULTS FROM A PHASE 3 TRIAL." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1675.1–1675. http://dx.doi.org/10.1136/annrheumdis-2020-eular.428.

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Background:DISCOVER 2 (DISC 2) is a Phase 3 trial of anti-IL-23-specific mAb guselkumab (GUS) in psoriatic arthritis (PsA) pts, who experience impaired physical function, resulting in disability, work productivity loss, and economic consequences.1Objectives:To evaluate the effect of GUS on impaired work productivity and daily activity in DISC 2 using the Work Productivity and Activity Impairment Questionnaire: Psoriatic Arthritis (WPAI-PsA).Methods:Bio-naïve adults with active PsA despite nonbiologic DMARDs &/or NSAIDs received subcutaneous GUS 100 mg every (q) 4 weeks (W); GUS 100 mg W0,

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Giannini, M., A. L. Charles, M. Pizzimenti, et al. "POS0876 SARCOPENIA IN MYOSITIS PATIENTS: A MARKER OF MUSCLE DAMAGE ASSOCIATED WITH HANDICAP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 694.1–694. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3248.

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Background:Myositis are systemic autoimmune rare diseases characterized by muscle inflammation and weakness. Even though the signs of active disease have been resolved, myositis patients frequently present residual muscle weakness, decreased physical performance and sustained disability. This condition has been coined on the term “damage” (as opposed to “activity”).Sarcopenia is a frequent, progressive and generalized skeletal muscle disorder characterized by low muscle strength and mass leading to handicap, decreased quality of life and increased mortality.1Prevalence and significance of sarc

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Swaminathan, Mahesh, Kiyomi Morita, Yan Yuanqing, et al. "Clinical Heterogeneity of AML Is Associated with Mutational Heterogeneity." Blood 132, Supplement 1 (2018): 5240. http://dx.doi.org/10.1182/blood-2018-99-117287.

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Abstract BACKGROUND: AML is a group of clinically heterogeneous diseases. We hypothesized that heterogeneous presentation of AML is a reflection of equally heterogeneous genetic process during the leukemogenesis. METHODS: 536 AML patients (pts) bone marrow samples were analyzed by targeted capture exome sequencing of 295 genes. Extensive clinical-genotype correlation was performed using well annotated clinical data. RESULTS: The median age of the cohort was 62 years (IQR: 51-72) including 297 (55%) elderly (age ≥60), and 239 (45%) young (age <60) pts. Of the 536 pts, 308 (57%) pts had de no

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Khodunova, Elena E., Elena N. Parovichnikova, Irina V. Galtzeva, Sergey M. Kulikov, and Valeri G. Savchenko. "Pro- and Antiapoptotic Proteins Expression on Bone Marrow and Peripheral Blood CD34+Cells in Acute Leukemia (AL) Patients." Blood 118, no. 21 (2011): 4996. http://dx.doi.org/10.1182/blood.v118.21.4996.4996.

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Abstract Abstract 4996 It was shown that drug resistance, poor-risk cytogenetics and poor prognosis in AL is associated with high level of Bcl-2 expression and low Bax/Bcl-2 ratio (<0,3). Fas-antigen (CD95) as a protein triggering the extrinsic apoptotic pathway is differently expressed on hematopoietic precursors. More immature CD34+/CD38- AML blast cells have lower expression of Fas/Fas-L and lower Fas-induced apoptosis than CD34+/CD38+cells. CD34+/CD38− leukemia precursors also have a reduced sensitivity to daunorubicin in vitro and increased expression of multidrug resistance genes (mrp

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Kaltenhauser, Simone, Clara F. Weber, Huang Lin, et al. "Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018." JAMA Network Open 6, no. 5 (2023): e2314193. http://dx.doi.org/10.1001/jamanetworkopen.2023.14193.

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ImportanceAside from widely known cardiovascular implications, higher weight in children may have negative associations with brain microstructure and neurodevelopment.ObjectiveTo evaluate the association of body mass index (BMI) and waist circumference with imaging metrics that approximate brain health.Design, Setting, and ParticipantsThis cross-sectional study used data from the Adolescent Brain Cognitive Development (ABCD) study to examine the association of BMI and waist circumference with multimodal neuroimaging metrics of brain health in cross-sectional and longitudinal analyses over 2 ye

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Sagatys, Elizabeth, Lynn Moscinski, Sophie Dessureault, Eduardo Sotomayor, and Hernani Cualing. "Analysis of T-Cell Subpopulations in the Lymph Nodes of Patients with Mantle Cell Lymphoma." Blood 110, no. 11 (2007): 1580. http://dx.doi.org/10.1182/blood.v110.11.1580.1580.

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Abstract Mantle cell lymphoma (MCL) is an aggressive and incurable B-cell NHL characterized by a high relapse rate. Novel treatments capable of providing and/or sustaining more durable responses in MCL patients are clearly needed. Manipulation of the immune system to unleash its protective effect might induce durable responses in MCL. To effectively harness the immune system against MCL, it is important to understand how T-cells interact with malignant B-cells that reside where immune responses are normally initiated. In the present study, we evaluated the number and phenotype of T-cells prese

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Mulrooney, Daniel A., Qi Liu, Farideh Bagherzadeh-Khiabani, et al. "Predicting valvular heart disease in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study (CCSS) and St. Jude Lifetime Cohort (SJLIFE)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 10070. https://doi.org/10.1200/jco.2025.43.16_suppl.10070.

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10070 Background: Radiotherapy (RT)-related valvular heart disease (VHD) is an understudied late toxicity of childhood cancer therapy. We aimed to define the risk of VHD with clinical data available at 5 and 20 years from cancer diagnosis. Methods: Mean heart RT doses were estimated for participants of the CCSS and SJLIFE cohorts treated with RT. Two piecewise exponential regression prediction models were developed in the CCSS, from entry into survivorship (5 years post cancer diagnosis) and 20 years post diagnosis (inclusive of age- and lifestyle-acquired risk factors), to assess subsequent r

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Alten, R., X. Mariette, R. M. Flipo, et al. "POS0447 PHYSICAL FUNCTION IN PATIENTS WITH RA, STRATIFIED BY SEROSTATUS AND TREATMENT LINE, FOLLOWING SC ABATACEPT: POST HOC ANALYSIS OF AN OBSERVATIONAL, 2-YEAR STUDY CONDUCTED IN ROUTINE CLINICAL PRACTICE (ASCORE)." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 453–54. http://dx.doi.org/10.1136/annrheumdis-2021-eular.903.

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Background:RA is characterised by the production of autoantibodies, including RF and anti-citrullinated protein antibodies (ACPAs).1 Seropositive disease is associated with poorer prognosis in patients with RA,2 and response to different treatments has been shown to vary based on ACPA status.3 ASCORE (Abatacept SubCutaneOus in Routine Clinical PracticE; NCT02090556) was a 2-year, observational, prospective, multicentre study of SC abatacept for the treatment of RA.4Objectives:This post hoc analysis of the ASCORE study evaluated patient-reported outcomes, assessed using HAQ-DI, by RF/ACPA seros

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Ehrhardt, Matthew J., Qi Liu, Stephanie B. Dixon, et al. "Association of Modifiable Health Conditions and Social Determinants of Health With Late Mortality in Survivors of Childhood Cancer." JAMA Network Open 6, no. 2 (2023): e2255395. http://dx.doi.org/10.1001/jamanetworkopen.2022.55395.

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ImportanceAssociations between modifiable chronic health conditions (CHCs), social determinants of health, and late mortality (defined as death occurring ≥5 years after diagnosis) in childhood cancer survivors are unknown.ObjectiveTo explore associations between modifiable CHCs and late mortality within the context of social determinants of health.Design, Setting, and ParticipantsThis longitudinal cohort study used data from 9440 individuals who were eligible to participate in the St Jude Lifetime Cohort (SJLIFE), a retrospective cohort study with prospective clinical follow-up that was initia

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Mooradian, Meghan J., Ling Cai, Alice Wang, Yao Qiao, Pratibha Chander, and Ryan M. Whitaker. "Durvalumab After Chemoradiotherapy in Patients With Unresectable Stage III Non–Small Cell Lung Cancer." JAMA Network Open 7, no. 4 (2024): e247542. http://dx.doi.org/10.1001/jamanetworkopen.2024.7542.

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ImportanceThe PACIFIC trial established consolidation durvalumab as the standard of care following chemoradiotherapy (CRT) for patients with unresectable stage III non–small cell lung cancer (NSCLC). Understanding its benefit in routine US clinical practice is critical.ObjectiveTo report characteristics, treatment patterns, and outcomes of patients who did or did not receive durvalumab.Design, Setting, and ParticipantsTwo prespecified cohorts were curated in this retrospective cohort study (SPOTLIGHT). Deidentified patient-level data from a US database (Flatiron Health) were analyzed. Patients

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Mikhaleva, Mariia, Svitlana Tyekucheva, Kiyomi Mashima, Stacey M. Fernandes, Matthew S. Davids, and Jennifer R. Brown. "Higher Mutational Burden Is an Independent Predictor of Shorter Time to First Treatment in Untreated Chronic Lymphocytic Leukemia Patients." Blood 142, Supplement 1 (2023): 3270. http://dx.doi.org/10.1182/blood-2023-173738.

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Background. Recent advancements in next-generation sequencing (NGS) technologies have revolutionized the ability to comprehensively profile chronic lymphocytic leukemia (CLL), unveiling various molecular lesions. Complex mutational landscapes and diverse combinatorial patterns of genetic alterations lead to heterogeneity of clinical course and outcomes. The primary objective of this study was to identify patterns of co-occurrence (CO) and mutual exclusivity (ME) among mutations in CLL and their impact on time to first treatment (TTFT). Methods. The cohort included 795 treatment-naïve (TN) pati

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Rea, Daniel, S. Pirrie, L. Hayward, et al. "Abstract RF3-07: ROSCO: Response to Optimal Selection of neoadjuvant Chemotherapy in Operable breast cancer: Randomised phase III, stratified biomarker trial of neoadjuvant 5-Fluorouracil,Epirubicin & Cyclophosphamide vs Docetaxel & Cyclophosphamide chemotherapy." Clinical Cancer Research 31, no. 12_Supplement (2025): RF3–07—RF3–07. https://doi.org/10.1158/1557-3265.sabcs24-rf3-07.

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Abstract Biomarkers for specific cytotoxic chemotherapy sensitivity could better inform drug selection. Both CEP17 duplication and abnormal Topoisomerase 2 copy number appear associated with anthracycline sensitivity in the adjuvant setting (Bartlett et al 2015). This data is however not currently applied clinically. Taxanes are a routine component of adjuvant and neoadjuvant chemotherapy either in combination or sequenced with anthracyclines, or increasingly used in the absence of anthracyclines. ROSCO: ISRCTN15094808 was designed to prospectively evaluate the clinical utility of these two bi

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Slichter, Sherrill J., Lynda Fitzpatrick, Esther Pellham, Mary Kay Jones, S. Lawrence Bailey, and Irena Gettinger. "In Vivo Viability of Platelets Stored in Whole Blood at 4°C." Blood 126, no. 23 (2015): 2338. http://dx.doi.org/10.1182/blood.v126.23.2338.2338.

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Abstract Background: Trauma surgeons have suggested that the optimal transfusion support for actively bleeding patients may be a 1:1:1 ratio of red cells, plasma and platelets (plts). Therefore, the only reason to give component therapy - rather than whole blood (WB) - for these patients may be because of the poor post-transfusion survivals of plts stored at 4°C. However, for trauma/surgical patients, even short plt survivals may be sufficient to allow the surgeon enough time to repair the injury. We report the "first ever" data on the post-storage viability of plts stored at 4°C beyond 3 days

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Rodeghiero, Francesco, Andrew Provan, Michael Steurer, Bertrand Godeau, Nancy Carpenter, and Georg Kreuzbauer. "Pooled Analysis of Safety and Efficacy of Romiplostim in Splenectomized and Nonsplenectomized Patients (pts) with Immune Thrombocytopenia (ITP)." Blood 124, no. 21 (2014): 4199. http://dx.doi.org/10.1182/blood.v124.21.4199.4199.

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Abstract Introduction: Romiplostim is a thrombopoietin receptor agonist approved for use in adult pts with ITP. Pooled analyses of combined pt data from romiplostim ITP clinical studies have previously been reported. Here we report updated safety and efficacy data according to baseline splenectomy status. Methods: Data from adult pts in 13 completed ITP studies with romiplostim were analysed up to June 2014. Pts received romiplostim, placebo or medical standard of care (SOC) and data from the placebo/SOC arms were pooled. All 13 studies were included in analyses of baseline pt characteristics

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Gleeson, Mary, David Cunningham, Eliza A. Hawkes, et al. "Risk of CNS Relapse with Diffuse Large B-Cell Lymphoma (DLBCL) in the Rituximab Era: Results from the UK NCRI R-CHOP 14 v 21 Trial." Blood 124, no. 21 (2014): 1723. http://dx.doi.org/10.1182/blood.v124.21.1723.1723.

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Abstract Background: Central Nervous System (CNS) relapse of Diffuse Large B-cell Lymphoma (DLBCL) is associated with a poor prognosis. Prior to the advent of rituximab the incidence of CNS relapse without CNS prophylaxis was around 5% in most unselected series. The risk in the rituximab era appears to be decreased in some but not all reported series (2.2-6.4%). CNS prophylaxis may be administered to patients deemed to be at high-risk but indications are not standardised. Methods: The randomised phase III UK R-CHOP-14 vs 21 trial assessed rituximab, cyclophosphamide, doxorubicin, vincristine,

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Martínez-Vidal, M. P., C. Fernández-Carballido, L. Otero-Varela та ін. "POS0638 SURVIVAL OF BIOSIMILAR ANTI-TNFΑ BLOCKERS COMPARED TO ORIGINATOR MOLECULES IN RHEUMATOLOGY: RESULTS FROM THE BIOBADASER COHORT". Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 595.1–595. http://dx.doi.org/10.1136/annrheumdis-2023-eular.1790.

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BackgroundRecent data from a large cohort showed that biosimilars had no shorter survival than their originator molecules [1]. Although the survival of biological therapies in real practice has been recently analyzed in Spanish patients with rheumatic diseases (2), we do not know if there are differences in treatment survival, depending on whether the patients receive an originator or a biosimilar molecule.ObjectivesThe main objective of this study was to compare the retention rate between subcutaneous biosimilar TNFα-blocker molecules and their originators. The secondary objective was to anal

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Garcia-Marco, Jose A., Javier Lopez-Jimenez, Secundino Ferrer, et al. "Rituximab Maintenance Treatment After Combined Fludarabine, Cyclophosphamide and Rituximab In Previously Untreated Patients with Progressive B-Cell Chronic Lymphocytic Leukemia (CLL): Interim Analysis of An Ongoing Phase II Multicenter Trial On Behalf of the Spanish CLL Study Group (GELLC)." Blood 116, no. 21 (2010): 2448. http://dx.doi.org/10.1182/blood.v116.21.2448.2448.

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Abstract Abstract 2448 Introduction. Combination of Rituximab (R) with fludarabine (F) and cyclophosphamide (C) as first line treatment of B-CLL, results in a high complete response rate, improved progression free and overall survival compared with FC in randomised trials (Hallek et al, Blood 2009). However, more than 30% of patients relapse or show disease progression at 3–4 years after FR or FCR treatment (Byrd et al., Blood 2005; Keating et al., J Clin Oncol 2005). We report on the efficacy and safety results of an interim analysis after one year of Rituximab maintenance (Rm) following FCR

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Aringer, M., L. Arnaud, C. Peschken, et al. "POS0731 ASSOCIATION OF PATIENT-REPORTED OUTCOMES WITH TYPE I INTERFERON GENE SIGNATURE FROM THE INTERNATIONAL SYSTEMIC LUPUS ERYTHEMATOSUS PROSPECTIVE OBSERVATIONAL COHORT STUDY (SPOCS)." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 648–49. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1181.

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BackgroundThe aim of the Systemic Lupus Erythematosus Prospective Observational Cohort Study (SPOCS) is to examine the disease course of patients with systemic lupus erythematosus (SLE) in relation to their type I interferon gene signature (IFNGS) status.1 IFNGS has been associated with SLE disease activity.2ObjectivesTo identify associations between IFNGS status and patient-reported outcomes (PROs) among patients receiving clinical care while enrolled in SPOCS.MethodsThis noninterventional, international, prospective, observational cohort study included adult patients (≥18 years) with moderat

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Moreau, Philippe, A. Keith Stewart, Antonio Lazzaro, et al. "Efficacy and Safety of Once-Weekly vs Twice-Weekly Carfilzomib Plus Dexamethasone: Subgroup Analysis of the Phase 3 A.R.R.O.W. Study (NCT02412878) By Prior Lines." Blood 132, Supplement 1 (2018): 3244. http://dx.doi.org/10.1182/blood-2018-99-114863.

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Abstract Introduction: The phase 3 A.R.R.O.W. study (NCT02412878) has shown a favorable benefit-risk profile of once-weekly carfilzomib (K) at 70 mg/m2 over twice-weekly K at 27mg/m2 plus dexamethasone (d) for the treatment of patients (pts) with relapsed and refractory multiple myeloma (RRMM) (Moreau. Lancet Oncol. 2018;19:953-964). Once-weekly significantly improved progression-free survival (PFS) compared with twice-weekly (median 11.2 vs 7.6 months [mos]; hazard ratio [HR]: 0.69; 95% confidence interval [CI]: 0.54, 0.88; P=0.0014). Herein, we present a subgroup analysis of once-weekly vs t

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