Log in

Relevant bibliographies by topics / 8-hydroxyquinoline

Contents

Journal articles
Dissertations / Theses
Books
Book chapters
Conference papers
Reports

Academic literature on the topic '8-hydroxyquinoline'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 April 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic '8-hydroxyquinoline.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "8-hydroxyquinoline"

1

MARRUGO-GONZALEZ, Alonso Jose, Valery D. ORLOV, and Roberto FERNANDEZ-MAESTRE. "1,3,5-TRIARYL 2-PYRAZOLINES WITH 8-HYDROXYQUINOLINIC SUBSTITUENT: SYNTHESES, PHOTOPHYSICAL PROPERTIES, AND BIOLOGICAL ACTIVITY." Periódico Tchê Química 12, no. 24 (August 20, 2015): 51–62. http://dx.doi.org/10.52571/ptq.v12.n24.2015.51_p_24_pgs_51_62.pdf.

Full text

Abstract:

1,3,5-triaryl-2-pyrazolines are organic luminophores with arylic radicals that show a wide biological activity and are used as liquid scintillators and electro-optic materials. Experimental. Eleven 2-pyrazolines were synthesized from phenylhidrazine and chalcones of the 8-hydroxyquinoline series: 3-(8-hydroxyquinolin-5-yl)-1-(3-R)-phenylprop-2-enone and 1-(8-hydroxyquinolin-5-yl)-3--(3-R)-phenylprop-2-enone, where R = H, CH3, OCH3, N(CH3)2, Cl, Br, and NO2. The structures were confirmed by elemental analysis, IR, 1H-NMR, and electronic spectroscopy. Results and discussion. The 1- and 3-aryl substituents of the pyrazoline ring produced shifts to shorter or longer wavelengths, in absorbance and fluorescence. The electron acceptor hydroxyquinolinic fragment influenced the absorption and luminescence spectra; the possible cause of low quantum yields in pyrazolines (1-phenyl-3-(4-R phenyl)-5-(8-hydroxyquinolinil-5)-2-pyrazoline) may be the specific intramolecular fluorescence quenching in bicromophores, characteristic of 5-acceptor substituted pyrazolines, and, in series (1-phenyl-5-(4-R phenyl)-3-(8-hydroxyquinolinil-5)-2-pyrazoline) of excited-state intramolecular proton transfer (ESIPT) reactions, and the increasing donor-acceptor intramolecular interaction of their excited molecules; Density functional calculations (method PM6) were used to probe the electronic structure and energy ordering of the emissive and the electron-transfer states; PM6 results agreed with the experimental data. 1-phenyl-3-(4-R phenyl)-5-(8-hydroxyquinolinil-5)-2-pyrazoline showed fungistatic and fungicide activities. Additionally, all our pyrazolines showed wide theoretical biological activities.

APA, Harvard, Vancouver, ISO, and other styles

2

Suwanjang, Wilasinee, Supaluk Prachayasittikul, and Virapong Prachayasittikul. "Effect of 8-hydroxyquinoline and derivatives on human neuroblastoma SH-SY5Y cells under high glucose." PeerJ 4 (August 31, 2016): e2389. http://dx.doi.org/10.7717/peerj.2389.

Full text

Abstract:

8-Hydroxyquinoline and derivatives exhibit multifunctional properties, including antioxidant, antineurodegenerative, anticancer, anti-inflammatory and antidiabetic activities. In biological systems, elevation of intracellular calcium can cause calpain activation, leading to cell death. Here, the effect of 8-hydroxyquinoline and derivatives (5-chloro-7-iodo-8-hydroxyquinoline or clioquinol and 8-hydroxy-5-nitroquinoline or nitroxoline) on calpain-dependent (calpain-calpastatin) pathways in human neuroblastoma (SH-SY5Y) cells was investigated. 8-Hydroxyquinoline and derivatives ameliorated high glucose toxicity in SH-SY5Y cells. The investigated compounds, particularly clioquinol, attenuated the increased expression of calpain, even under high-glucose conditions. 8-Hydroxyquinoline and derivatives thus adversely affected the promotion of neuronal cell death by high glucose via the calpain-calpastatin signaling pathways. These findings support the beneficial effects of 8-hydroxyquinolines for further therapeutic development.

APA, Harvard, Vancouver, ISO, and other styles

3

Wang, Hong Liang, Jun Hao Zhang, Zhao Kun Qu, Liang Jia, and Jiao Long Wang. "Synthesis and Photoluminescence Property of Tris(8-hydroxyquinoline) Bismuth Rod-Like Structures at Room Temperature." Advanced Materials Research 415-417 (December 2011): 1382–86. http://dx.doi.org/10.4028/www.scientific.net/amr.415-417.1382.

Full text

Abstract:

Tris(8-hydroxyquinoline) bismuth complex has been synthesized with a facile method in a mixed solvent system containing bismuth nitrate and 8-hydroxyquinolineat at room temperature. The molecular formula of the products is speculated by the C, H and N element analysis and thermal gravimetric analysis, and FTIR was also utilized to measure the structure, which further confirms the molecular formula of the products. The observation of FESEM and TEM shows that the morphology of tris(8-hydroxyquinoline) bismuth complexes is rod-like structure. The results of photoluminescence emission indicate that inorganic element plays key roles in the luminescence property. According to the results, we found that the photoluminescence of tris-(8-hydroxyquinoline) bismuth is stronger than that of 8-hydroxyquinoline.

APA, Harvard, Vancouver, ISO, and other styles

4

MARRUGO-GONZALEZ, A. Jose, V. D. ORLOV, and Roberto FERNANDEZ-MAESTRE. "SYNTHESIS OF 2,3-DIHYDRO-1H-1,5-BENZODIAZEPINES CONTAINING THE 8- HYDROXYQUINOLINIC FRAGMENT." Periódico Tchê Química 13, no. 26 (August 20, 2016): 14–32. http://dx.doi.org/10.52571/ptq.v13.n26.2016.14_periodico26_pgs_14_32.pdf.

Full text

Abstract:

Benzodiazepines are used as anxiolytic, hypnotic, sedative, and antidepressant drugs and to treat anxiety, insomnia, and epileptic seizures and show other types of biological activities. In this study, ten new 4(2)-(8-hydroxyquinolinil-5)-2(-4)-aryl-2,3-dihydro-1H-1,5-benzodiazepines and their rearrangement products, 2-substituted benzimidazoles, were synthesized from 1-aryl-3- (8-hydroxyquinolinil-5) propenone-1 (-3) and ophenylenediamine in methanol-triethylamine (1:1) solution. The reaction between the diamine and chalcones containing the 8-hydroxyquinoline fragment was carried out under mild conditions by base-catalysis amination of the β-enonic fragment of the chalcones followed by cyclo condensation. The structures of these compounds were studied by spectroscopic methods (IR and 1H-NMR) and their chelating properties were demonstrated. We calculated and discuss their theoretical biological activity and the influence of metal chelation on the electron acceptor hydroxyquinolinic fragment on the electronic spectra.

APA, Harvard, Vancouver, ISO, and other styles

5

Wang, Chengchao, Wei Zhang, Nianchen Zhou, Yansheng Qiu, Zhengping Cheng, and Xiulin Zhu. "Synthesis and Characterization of Well-Defined SolubleAlq3- andZnq2-Functionalized Polymers via RAFT Copolymerization." International Journal of Polymer Science 2010 (2010): 1–7. http://dx.doi.org/10.1155/2010/340926.

Full text

Abstract:

The reversible addition-fragmentation chain transfer (RAFT) copolymerizations of 2-((8-hydroxyquinolin-5-yl)methoxy)ethyl methacrylate (HQHEMA) with styrene (St) or methyl methacrylate (MMA) were successfully carried out in the presence of 2-cyanoprop-2-yl dithionaphthalenoate (CPDN). The polymerization behaviors showed the typical living natures by the first-order polymerization kinetics, the linear dependence of molecular weights of the polymers on the monomer conversions with the relatively narrow molecular weight distributions(Mw/Mn), and the successful chain extension experiments. The soluble polymers having tris(8-hydroxyquinoline)aluminum (Alq3) and bis(8-hydroxyquinoline) znic(II) (Znq2) side chains were obtained via complexation of the polymers with aluminium isopropoxide or zinc acetate in the presence of monomeric 8-hydroxyquinoline, which had strong fluorescent emission at 520 nm. The obtained polymers were characterized by GPC, NMR, UV-vis, and fluorescent spectra.

APA, Harvard, Vancouver, ISO, and other styles

6

RAGULIN, V. V., I. R. RAGULINA, and L. G. SHAKIROV. "ChemInform Abstract: Carboxylation of 8-Hydroxyquinoline to 8-Hydroxyquinoline-7-carboxylic Acid." ChemInform 26, no. 26 (August 17, 2010): no. http://dx.doi.org/10.1002/chin.199526159.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Fung, Man Kin, Alan Man Ching Ng, Aleksandra B. Djurišić, Wai Kin Chan, and Hai Wang. "Preparation of 8-hydroxyquinoline wires by decomposition of tris(8-hydroxyquinoline) aluminium." Journal of Experimental Nanoscience 7, no. 5 (June 21, 2012): 578–85. http://dx.doi.org/10.1080/17458080.2010.543992.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Ribeiro da Silva, Manuel A. V., Manuel João S. Monte, and M. Agostinha R. Matos. "Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8-hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline." Journal of Chemical Thermodynamics 21, no. 2 (February 1989): 159–66. http://dx.doi.org/10.1016/0021-9614(89)90127-4.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Cross, Jason P., and Peter G. Sammes. "A useful 8-hydroxyquinoline synthon." Journal of Chemical Research 2003, no. 11 (November 1, 2003): 704–5. http://dx.doi.org/10.3184/030823403322863003.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Yu, Gui, Dezhen Shen, Yunqi Liu, and Daoben Zhu. "Photodegradation of 8-hydroxyquinoline aluminum." Synthetic Metals 121, no. 1-3 (March 2001): 1433–34. http://dx.doi.org/10.1016/s0379-6779(00)01214-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

More sources

Dissertations / Theses on the topic "8-hydroxyquinoline"

1

Curry, Richard James. "Luminescence characterisation of aluminium and erbium tris (8-hydroxyquinoline)." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312173.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Knight, Cheryl Lynn. "Application of IR and NMR spectroscopy to certain complexes of 8-hydroxyquinoline and 8-aminoquinoline." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/22001.

Full text

Abstract:

The IR spectra of twenty-one transition metal complexes of 8-hydroxyquinoline over the range 700 - 50 cm⁻¹ are discussed in relation to their known or inferred structures. The complexes are of three types: (a) the bis(aquo) complexes of the first row transition metal(II) ions, [M(ox)₂(H₂O)₂] (M =Mn, Fe, Co, Ni, Cu, Zn); (b) the corresponding anhydrous complexes, [M(ox)₂]n (M=Mn, Co, Ni, Cu, Zn) and (c) the complexes of the metal(III) ions, [M(ox)₃] (M = Sc, V, Cr, Mn, Fe, Co, Ga, Rh and In). Deuterated 8-hydroxyquinoline was. synthesized by the Skraup synthesis and has been used to assist in the assignment of the metal-ligand modes. The assignment of these bands was further based on ⁶⁴,⁶⁸Zn labellihg of the bis(aquo) zinc chelate and on the effects of metal ion substitution in relation to structural considerations based on crystal field theory. An investigation of the IR spectra of a series of -tris, bis and mono(8-aminoquinoline) complexes of the first transition row metal(II) perchlorates and halides is reported.

APA, Harvard, Vancouver, ISO, and other styles

3

Pretorius, Alet. "A preliminary investigation of the potential anticancer properties of 8-hydroxyquinoline derivatives." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24884.

Full text

Abstract:

Derivatives of the quinoline moiety have been shown to exert a range of biological activities, including anti-neoplastic activity. The clinical application of quinoline derivatives in the treatment of malignancies has been limited due to non-selectivity. Four novel hydroxyquinoline derivatives were synthesised as potential anticancer agents. Each of these compounds contains the characteristic quinoline nucleus: a heterocyclic moiety containing a nitrogen atom. A hydroxyl group is present on C-8 and an azo bond links the heterocyclic quinoline core to a monocyclic benzene ring with various substituents. The aim of this study was to investigate the potential anticancer properties of the four hydroxyquinolines as pertains to their in vitro cytotoxicity, ability to circumvent multidrug resistance and possible mechanism of action. The acute in vivo toxicity profile of the two most promising compounds was also investigated. The tumour specificity of a compound is an indicator of the selective cytotoxicity of a compound towards cancer cells, while maintaining minimal toxicity towards normal cells. To this end the four hydroxyquinolines were screened on a range of commercially available cancer cell lines and primary (normal) cultures. The cancer cell lines used included human cervical adenocarcinoma (HeLa), human estrogen receptor positive breast cancer (MCF-7) and several resistant cancer cell lines. Chicken embryo fibroblasts and human lymphocytes were included as primary cell cultures. From the results the cancer cell lines most sensitive to each compound were identified: breast (MCF-7) and leukaemia (Jurkat) cells were most sensitive to HQ5, a resistant colon cancer cell line (COLO 320DM) was most susceptible to HQ6 and HQ7, and HQ10 was most effective against cervical cancer (HeLa). Data indicated that HQ5 and HQ10 displayed the highest tumour specificities and these two promising hydroxyquinoline derivatives were selected for further investigation. As quinoline derivatives have been reported to modulate multidrug resistance through the inhibition of the P-glycoprotein (P-gp) efflux pump, the effect of HQ5 and HQ10 on P-gp was evaluated in two experimental models. Firstly the experimental hydroxyquinolines were used in combination with the P-gp substrates doxorubicin, vinblastine and paclitaxel on three P-gp expressing cell lines to ascertain whether a synergistic combination could be observed. Secondly the direct effect of HQ5 and HQ10 on the function of P-gp was determined through the rhodamine 123 retention assay. According to the results obtained from the combination therapy, the combinations of the experimental compounds and the known chemotherapeutic agents tested were at most additive. Data obtained from the rhodamine 123 accumulation assay revealed that HQ5 and HQ10 did not inhibit P-gp in the three P-gp expressing cell lines tested but appeared to enhance P-gp activity. The mechanism of action of the two selected hydroxyquinolines was further investigated through flow cytometric analysis. The effect of HQ5 and HQ10 on the induction of apoptosis or necrosis in MCF-7 cells was determined. Results indicated that the two experimental compounds induced apoptosis in a dose and time dependent manner. After investigating the effect of the hydroxyquinolines on the cell cycle progression of MCF-7 cells, it was observed that HQ5 and HQ10 arrested the cell cycle at the G1 checkpoint. Results suggest that at higher concentrations of HQ5 inhibition resembled a G2 inhibitor. In an acute in vivo cytotoxicity study the tolerability and safety profile of HQ5 and HQ10 were investigated. After daily intraperitoneal administration of either of the two compounds at two concentrations, no obvious histological signs of toxicity were reported. However a dose of 2 mg/kg per day of HQ10 caused a significant reduction in body weight. Haematological analysis revealed that administration of 0.1 mg/kg of HQ5 resulted in a significant decrease in white cell count. No other haematological parameters studied showed any difference between the animals in the control and experimental groups. It was thus concluded that daily dosing of HQ5 and HQ10 was well-tolerated and caused no severe toxicity. Chronic in vivo toxicity profiles were not determined in this study. The in vitro studies suggested that HQ5 and HQ10 displayed promising anticancer properties. However, further investigation revealed several unfavourable characteristics, with regards to the solubility, purity and stability of these experimental hydroxyquinolines. In addition in vivo studies added further doubt on the success of these compounds in a clinical setting and it was concluded that these compounds were unsuitable for further development. Copyright
Dissertation (MSc)--University of Pretoria, 2011.
Pharmacology
unrestricted

APA, Harvard, Vancouver, ISO, and other styles

4

Tarverdi, Karnik. "Preparation and testing of lanthanum and neodymium with 8-hydroxyquinoline as potential biocide." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332067.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

McDonald, F. Crisp. "The study of 8-Hydroxyquinoline-2-Carboxyllic acid and its metal ion complexing properties /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/mcdonaldf/fcrispmcdonald.pdf.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Vu, Thi huyen. "Synthesis and Development New 8-Hydroxyquinoline Derivatives for the Treatment of Chlamydia trachomatis Infection." Thesis, Université de Paris (2019-....), 2020. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=4392&f=28906.

Full text

Abstract:

Chlamydia trachomatis, une bactérie à Gram négatif, est responsable, à la fois, de l'infection bactérienne sexuellement transmissible la plus diagnostiquée dans le monde et du trachome, une cause importante de cécité. Aucun vaccin n'est disponible mais deux antibiotiques (Azithromycine, Doxycycline) sont recommandés par l'Organisation Mondiale de la Santé. Toutefois, un échec du traitement est signalé chez 10 à 20% des patients et résulte probablement d'un manque de sensibilité des formes persistantes de la bactérie et des modestes concentrations intracellulaires des médicaments conventionnellement prescrits. Pour ces raisons, l'objectif de ma thèse était de proposer de nouveaux outils de lutte l'infection à C. trachomatis tels que de nouveaux dérivés de la 8-hydroxyquinoléine actifs contre cette bactérie. J'ai, tout d’abord, synthétisé de nouvelles molécules et évalué leur activité anti-chlamydiale ainsi que leurs propriétés chélatantes du fer. Le composé 1 résulte du couplage de l'acide 8-hydroxyquinoléine-2-carboxylique et de la Ciprofloxacine (Cip), un antibiotique actif contre C. trachomatis. Nous voulions obtenir des dérivés plus actifs que l'antibiotique-parent par ses propriétés chélatantes de métaux et son effet antibiotique. Le composé 1 présente effectivement une activité anti-chlamydiale plus élevée que la Cip mais cet effet ne semble pas lié à ses propriétés chélatantes du métal. En modifiant certains paramètres physicochimiques tels que la lipophilie, nous avons synthétisé plusieurs dérivés du composé 1. Nous avons également préparé un conjugué d'acide folique pour permettre sa délivrance aux cellules infectées via le récepteur de ce dernier. Tous les composés obtenus sont plus actifs que la Ciprofloxacine, l'un d'entre eux atteignant une activité au nanomolaire contre la bactérie.Dans la deuxième partie, nous avons étudié l'influence de la position du carbonyle sur les propriétés chélatantes du fer de la 8-hydroxyquinoléine. Pour cela, nous avons effectué une étude mixte expérimentale (synthèse organique, spectrophotométrie et calorimétrie de titrage isotherme) et théorique (théorie de la densité fonctionnelle). Deux dérivés esters de 8-hydroxyquinoléine, en position 2 et position 7, ont été synthétisés et les complexes de fer correspondants ont été étudiés. Nous avons démontré que selon la position du groupe attracteur d’électrons sur le squelette hétérocyclique, l'encombrement stérique peut déstabiliser le complexe de fer (III) en le forçant à adopter une structure déformée, éloignée de l'environnement octaédrique idéal.Dans la dernière partie, j'ai synthétisé et caractérisé des Carbone dots (CDs) d’acide folique et de Ciprofloxacine, comme nouveaux nano-objets pour cibler les cellules infectées et inhiber la croissance bactérienne. Les deux populations de CDs ont une taille de 4 à 5 nm, émettent en lumière bleue et présentent un comportement fluorescent indépendant de l'excitation. L’efficacité antibactérienne de ces nanoparticules est actuellement en cours d’étude
Chlamydia trachomatis, a Gram-negative bacterium, is responsible for both the most common sexually transmitted bacterial infection in the world and trachoma, an important cause of blindness worldwide. No vaccine is available but antibiotics (azithromycine, doxycycline) are recommended by the World Health Organization. However, treatment failure is reported 10-20% of patients and probably results from a lack of sensitivity of persistent forms of bacteria and modest intracellular concentrations of the conventionally prescribed drugs. For this reasons, the aim of my thesis was to propose new tools to fight C. trachomatis infection such as novel 8-hydroxyquinoline derivatives active against this bacterium.In the first part, I synthesised new compounds and evaluated their anti-chlamydia activity as well as their iron-chelating properties. Compound 1 results from the coupling of 8-hydroxyquinoline-2-carboxylic acid and Ciprofloxacin (Cip), a commercially available antibiotic. We wanted to obtain more active derivatives than the parent antibiotic through its metal-chelating properties and its antibiotic effect. Compound 1 presents a higher antichlamydia activity than Cip but this antibacterial effect seems not be linked to its iron-chelating properties. Modifying physicochemical parameters such as lipophilicity, we synthesized several derivatives. We also prepared a folic acid conjugate to enable its delivery to the infected cells through folic acid receptor. All compounds are more potent than Ciprofloxacin, one of them reaching nanomolar potency against C. trachomatis.In the second part, I studied the influence of the carbonyl position on the iron-chelating properties of the 8-hydroxyquinoline heterocycle. For this purpose, we performed a mixed experimental (organic synthesis, spectrophotometry and isothermal titration calorimetry) and theoretical (density-functional theory) study. Two 8-hydroxyquinoline ester-derivatives, at 2-position and 7-position, were synthesized and the corresponding iron-complexes were investigated. We demonstrated that according to the position of the withdrawing group on the heterocyclic skeleton, the steric hindrance can destabilize the iron(III) complex by forcing it to adopt a distorted structure far from the ideal octahedral environment.In the last part, I synthesized and characterized Carbon dots (CDs) from folic acid and Ciprofloxacin as new nano-tools to target the infected cells and inhibit the bacterial growth. Both populations of CDs have a 4-5 nm size, emit in blue light and present an excitation-independent fluorescent behaviour. These nanoparticles are actually under biological investigation

APA, Harvard, Vancouver, ISO, and other styles

7

Joaquim, Angélica Rocha. "Síntese de derivados de 8-hidroxiquinolina e avaliação da atividade antimicrobiana." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/181465.

Full text

Abstract:

A prospecção e síntese de novos derivados de 8-hidroxiquinolina está em ascensão devido às suas diversas atividades biológicas. Neste trabalho é relatada a síntese e avaliação da atividade antimicrobiana de novos derivados contendo uma sulfonamida substituída na posição 5 da 8-hidroxiquinolina ou um grupamento aminossubstituído na posição 7 da 5-cloro-8-hidroxiquinolina ou 5-cloro-8-metoxiquinolina. Os derivados 5-sulfonamidas foram preparados por clorossulfonação seguida da reação com a amina apropriada. Os derivados 7-aminossubstituído foram sintetizados através da metilação da hidroxila da posição 8, seguida da reação de cross-coupling catalisada por paládio e desmetilação. A avaliação da atividade antimicrobiana foi realizada através do método de microdiluição em caldo. Dentre os compostos sintetizados, 5a (da série 5-sulfonamidas) foi o mais potente, sendo ativo contra todas as espécies fúngicas testadas, além de apresentar importante atividade contra cepas de Staphylococcus aureus, e baixa toxicidade contra células VERO. Isso sugere que a introdução de um grupamento retirador de elétrons em para no substituinte arila da posição 5 é importante para a atividade antimicrobiana. Ainda, a nanoemulsão preparada contendo 5a manteve a atividade antifúngica da substância contra espécies de Candida spp. A série 7-aminossubstituído também apresentou resultados muito interessantes. Desta série, o composto 5i foi o mais potente. Isso sugere que grupamentos heterocíclicos hidrofílicos na posição 7 podem favorecer a atividade antifúngica. A presença da hidroxila livre na posição 8 parece ser essencial para a atividade antifúngica, pois os derivados protegidos por uma metila foram pouco ativos. Os derivados de 8-hidroxiquinolina 5a e 5i podem ser considerados para estudos posteriores na busca de novos agentes antimicrobianos.
The synthesis and screening of new 8-hydroxyquinoline derivatives is growing, due to their various biological activities. In this work, the synthesis and antimicrobial evaluation of new derivatives containing a substituted 5-sulfonamide in the 8-hydroxyquinoline or a substituted amino group at the 7-position of the 5-chloro-8-hydroxyquinoline or 5-chloro-8-methoxyquinoline is reported. The 5-sulfonamide derivatives were prepared by chlorosulfonation followed by the reaction with the appropriate amine. The 7-amino derivatives were synthesized by methylation of the 8-hydroxyquinoline, followed by palladium-catalyzed cross-coupling reaction and demethylation. The antimicrobial evaluation was tested by the broth microdilution method. Among all the prepared compounds, 5a (from the 5-sulfonamide series) was the most potent, being active against all the fungal species tested, while also showing important activity against Staphylococcus aureus strains, and low toxicity against VERO cells. This suggests that the introduction of an electron-withdrawing group at para-position of the N-aryl substituent is important for the activity. In addition, the prepared 5a nanoemulsion maintained the antifungal activity of the compound against Candida spp. The 7-amino series has also presented interesting results. In this series, 5i was the most potent compound. This suggests that the hydrophilic heterocyclic substituent at the 7-position was favorable to antifungal activity. The presence of the free hydroxyl at the 8-position is important for the antifungal activity, since the methyl-protected derivatives were poorly active. The 8-hydroxyquinoline derivatives 5a and 5i may be considered for further studies in the search for novel antimicrobial agents.

APA, Harvard, Vancouver, ISO, and other styles

8

Gregušová, Michaela. "Modifikace techniky difúzních gelů (DGT) pro charakterizaci přírodních systémů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2010. http://www.nusl.cz/ntk/nusl-233319.

Full text

Abstract:

Diffusive gradient in thin film technique (DGT) represents a relatively new approach for in situ determinations of labile metal-species in aquatic systems. The DGT device passively accumulates labile species from the solution while deployed in situ, and therefore contamination problems associated with conventional collection and filtration procedures are eliminated. This study deals with a possible modification of DGT technique. The key of using DGT technique for speciation analysis of metals is to find out suitable binding phase and diffusion layer. The new resin gel based on Spheron Oxin (5 sulphophenyl-azo-8-hydroxyquinoline) ion exchanger with a higher selectivity to trace metals than Chelex 100 could potentially provide more information on metals speciation in aquatic systems. The performance of this new binding phase was tested for the determination of Cd, Cu, Ni, Pb and U under laboratory conditions. The hydrogel layer based on poly(2-hydroxyethyl methacrylate) was synthesized and tested as a new diffusion gel for application in DGT technique.

APA, Harvard, Vancouver, ISO, and other styles

9

Aprahamian, Vicken Haroutiun. "The behaviour and control of impurities during the solvent extraction of platinum metals with an alkylated 8-hydroxyquinoline /." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61135.

Full text

Abstract:

In order to understand and control the deportment of common impurity elements in the Pt(IV)-Pd(II)-HCl-8-hydroxyquinoline (TN 1911)$ sp{ rm a}$ system, their solvent extraction chemistry in chloride solution has been studied. The investigated elements were Fe(III), Cu(II), Ni(II), Zn(II), Pb(II), Sn(IV), Ag(I), As(V), Sb(V), Bi(III), Se(IV) and Te(IV). Extraction experiments carried out using multi-element and single element feed solutions helped to elucidate the extraction behaviour of the elements with the extractant TN 1911. From the collected data it was deduced that the majority formed anionic chlorocomplexes and extracted via the ion-pair mechanism involving the protonated extractant. Consequently, scrubbing procedures were developed to control the deportment of these elements. These scrubbing steps were then incorporated into a tentative flowsheet which was simulated in a batch-wise fashion in the laboratory. The most contaminating elements were found to be Zn(II), Pb(II), Ag(I), Te(IV), Se(IV) and Bi(III). The first five were effectively scrubbed with 2.0M HCl whereas Bi(III) could only be scrubbed with 2.0M H$ sb2$SO$ sb4$ at A/O ratios of $>$3:1. The element Sn(IV) which was found to build-up in the organic, could only be scrubbed with a 1.0M NaOH solution for long contract times (60 minutes). ftn$ sp{ rm a}$A proprietary alkylated derivative of 8-hydroxyquinoline (Schering Berlin AG).

APA, Harvard, Vancouver, ISO, and other styles

10

AVILA, HAROLD JOSE CAMARGO. "DEVELOPMENT AND CHARACTERIZATION OF ORGANIC ELECTROLUMINESCENT DEVICES (OLEDS) BASED ON NEWS TETRAKIS 8-HYDROXYQUINOLINE OF RARE-EARTH COMPLEXES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2012. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=20308@1.

Full text

Abstract:

PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O Alq3 é um dos mais importantes semicondutores orgânicos utilizados como transportador de elétrons e emissor em dispositivos eletroluminescentes (OLEDs). Este trabalho apresenta o estudo das propriedades ópticas, eletroquímicas, elétricas e morfológicas de três complexos baseados em íons de terras raras (TR) ligados à 8-hidroxiquinolina (q), Li[TR(q)4] (TR igual a La3mais, Y3mais e Lu3mais). Os espectros de absorção na região UV-Vis possuem máximos em 382nm para os complexos de Y3mais/La3mais e em 388nm para o complexo de Lu3mais. Os espectros de fotoluminescência dos complexos correspondem à emissão da (q) e não exibem as linhas características de emissão dos íons de terras raras. Os dados de analise térmica indicam que os complexos são termicamente estáveis até 325 graus Celsius e que apresentaram H2O absorvida da atmosfera. Os OLEDs fabricados e caracterizados neste trabalho foram de dois tipos: bicamadas e multicamadas.A1)ITO/NPB(25nm)/Li[TR](q)4](40nm)/Al(120nm);A2)ITO/NPB(25nm)/[Eu(DBM)3phen](20nm)/BCP(10nm)/Li[TR(q)4](20nm)/Al(120nm). Os OLEDs bicamadas apresentaram, em seus espectros de eletroluminescência, as bandas de emissão da (q) entre 520 ate 540nm. Os OLEDs multicamadas foram fabricados para testar a eficácia dos complexos Li[TR(q)4] como camadas transportadoras. Este trabalho evidenciou uma interessante dependência entre o pico máximo da emissão eletroluminescente e o raio iônico dos íons de TR. Os OLEDs baseados nos complexos Li[TR(q)4] apresentaram boas características quando comparadas com os OLEDs baseados Alq3, mostrando-se compostos promissores para o desenvolvimento de dispositivos orgânicos.
The Alq3 is one of the most important organic semiconductors used as electron transporting and emitting material in organic electroluminescent devices (OLEDs). This work presents the investigation of the optical, electrochemical, electrical and morphological properties of three complexes based in ions of rare earth (RE) coordinated to 8-hydroxyquinoline (q), Li[RE(q)4] (RE equal La3more, Y3more and Lu3more). The UV-Vis absorption spectrum present the maximum absorption at: 382nm for Y3more/La3more complexes and 388nm for the Lu3more complex. The photoluminescence spectra of the complexes correspond to the emission of the (q) and does no exhibit characteristic lines of the rare earths ions. The thermal analysis data indicate that the complexes are thermally stable until 325 Celsius degrees and that showed H2O molecules absorbed from the atmosphere. The fabricated and characterized OLEDs in this work were of two types: bilayer and multilayer.A1)ITO/NPB(25nm)/Li[TR(q)4](40nm)/Al(120nm);A2)ITO/NPB(25nm)/[Eu(DBM)3phen](20nm)/BCP(10nm)/Li[TR(q)4](20nm)/Al(120nm). The bilayer OLEDs showed, in their electroluminescence spectra, the emission bands of the (q) between 520 until 540nm. The multilayer OLEDs were fabricated to test the efficiency of the complexes Li[TR(q)4] as transport layers. This work showed an interesting dependence between the EL emission peak and the ionic radius of the of RE ions. The OLEDs based on the Li[RE(q)4] complexes presented good characteristics when compared to the OLEDs based on Alq3, showing as promising compounds to the organic devices development.

APA, Harvard, Vancouver, ISO, and other styles

More sources

Books on the topic "8-hydroxyquinoline"

1

Cölle, Michael. The electroluminescent material Alq3: Thermal, structural and photophysical propertires. Berlin: Logos Verlag, 2004.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

2

Karim, Salma. Synthesis and study of metal-ion capacities of 8-hydroxyquinoline immobilised on different grades of silica gel. Uxbridge: Brunel University, 1988.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

3

Khangura, Ranjit Singh. Charge injection properties of aluminum tris(8-hydroxyquinoline) based devices . 2005.

Find full text

APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "8-hydroxyquinoline"

1

Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetracyanonotrosylchromate(I) complex with 8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, 938–39. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49202-4_460.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Haesebroek, G. "Purity and long-term stability of 8-hydroxyquinoline-based metal extractants." In EMC ’91: Non-Ferrous Metallurgy—Present and Future, 301–4. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-011-3684-6_32.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetranuclear manganese(III)-oxo-acetate complex with 8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, 916. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54228-6_520.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetranuclear manganese(III)-oxo-acetate complex with 8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, 917. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54228-6_521.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetranuclear manganese(III)-oxo-acetate complex with 8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, 918. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54228-6_522.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetranuclear manganese(III)-oxo-benzoate complex with 8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, 919. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54228-6_523.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Pardasani, R. T., and P. Pardasani. "Magnetic properties of tetranuclear manganese(III)-oxo-acetate complex with 5-chloro-8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, 920. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-54228-6_524.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Pardasani, R. T., and P. Pardasani. "Molar magnetic moment of mixed ligandcomplex of cobalt(II) with malonic acid and 8-hydroxyquinoline." In Magnetic Properties of Paramagnetic Compounds, Magnetic Susceptibility Data, Volume 2, 409–10. Berlin, Heidelberg: Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-62466-1_177.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Rahier, Renaud, Houda Abla, Yani Arhab, Alexandre Noiriel, and Abdelkarim Abousalham. "Direct and Continuous Measurement of Phospholipase D Activities Using the Chelation-Enhanced Fluorescence Property of 8-Hydroxyquinoline." In Lipases and Phospholipases, 129–38. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-8672-9_6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Jadhav, P. J., B. N. Limketkai, and M. A. Baldo. "Effective Temperature Models for the Electric Field Dependence of Charge Carrier Mobility in Tris(8-hydroxyquinoline) Aluminum." In Organic Electronics, 45–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/12_2009_5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "8-hydroxyquinoline"

1

Roy, V. Arul Lenus, Chung Yin Kwong, Aleksandra B. Djurisic, Ramachandra B. Pode, T. K. Gundu Rao, and Wai Kin Chan. "Improvement in the environmental stability of tris(8-hydroxyquinoline) aluminum by substitution of sulphonic acid in 8-hydroxyquinoline ligand." In Optical Science and Technology, SPIE's 48th Annual Meeting, edited by Zakya H. Kafafi and Paul A. Lane. SPIE, 2004. http://dx.doi.org/10.1117/12.503009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Derkowska-Zielinska, Beata. "Nonlinear optical properties of tris-(8-hydroxyquinoline)-aluminum." In 2016 18th International Conference on Transparent Optical Networks (ICTON). IEEE, 2016. http://dx.doi.org/10.1109/icton.2016.7550426.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Djurisic, Aleksandra B., Chung Yin Kwong, Weiling Guo, TszWai Lau, Zheng T. Liu, HoiSing Kwok, Lillian S. M. Lam, and Wai Kin Chan. "Optical funtions of tris (8-hydroxyquinoline) aluminum (Alq3)." In Symposium on Integrated Optoelectronic Devices, edited by Bernard Kippelen and Donal D. C. Bradley. SPIE, 2002. http://dx.doi.org/10.1117/12.470447.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Lougdali, M., A. Korcala, P. Plociennik, Y. El Kouari, M. Zazoui, Y. Abboud, A. EL Bouari, and B. Sahraoui. "Physical Properties of Bis-(8-hydroxyquinoline) Magnesium Thin Films." In 2019 21st International Conference on Transparent Optical Networks (ICTON). IEEE, 2019. http://dx.doi.org/10.1109/icton.2019.8840182.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Petit, S., G. Coquerel, J. Langlet, and E. Kassab. "Theoretical study of intramolecular proton transfer in 8-hydroxyquinoline." In The first European conference on computational chemistry (E.C.C.C.1). AIP, 1995. http://dx.doi.org/10.1063/1.47682.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Jampilek, Josef, Jiri Kos, Petra Machalova, Matus Pesko, Tomas Gonec, Pavel Bobal, Michal Oravec, Tibor Liptaj, and Katarina Kralova. "Preparation and Herbicidal Activity of Halogenated 8-Hydroxyquinoline-2-carboxanilides." In The 17th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-b013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Zawadzka, A., P. Plociennik, J. Strzelecki, A. Korcala, and B. Sahraoui. "Photophysical properties of thin films containing metal and 8-hydroxyquinoline complexes." In 2015 17th International Conference on Transparent Optical Networks (ICTON). IEEE, 2015. http://dx.doi.org/10.1109/icton.2015.7193543.

Full text

APA, Harvard, Vancouver, ISO, and other styles

8

Junbiao Peng, Runguang San, Yuguang Ha, and Shiyong Lit. "Studies on the organic electroluminescence of 8-hydroxyquinoline rera earth chelate." In International Conference on Science and Technology of Synthetic Metals. IEEE, 1994. http://dx.doi.org/10.1109/stsm.1994.835787.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Le, Quoc T., M. G. Mason, Li Yan, Vi-En Choong, Eric W. Forsythe, Ching W. Tang, and Yongli Gao. "Interface formation between Al and Ca with tris-(8-hydroxyquinoline) aluminum." In Optoelectronics '99 - Integrated Optoelectronic Devices, edited by Bernard Kippelen. SPIE, 1999. http://dx.doi.org/10.1117/12.348384.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Ajward, A. M., X. Wang, and H. P. Wagner. "Intensity and temperature-dependent photoluminescence of tris (8-hydroxyquinoline) aluminum films." In THE PHYSICS OF SEMICONDUCTORS: Proceedings of the 31st International Conference on the Physics of Semiconductors (ICPS) 2012. AIP, 2013. http://dx.doi.org/10.1063/1.4848344.

Full text

APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "8-hydroxyquinoline"

1

Yang, Zhaoxia, Jerald S. Bradshaw, Paul B. Savage, Krzysztof E. Krakowiak, and Reed M. Izatt. Synthesis of Tetraazacrown Ethers Containing Two 8-Hydroxyquinoline Side Arms. Fort Belvoir, VA: Defense Technical Information Center, April 1999. http://dx.doi.org/10.21236/ada361693.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Song, H. C., J. S. Bradshaw, Y. W. Chen, G. P. Xue, and J. A. Chiara. Syntheses of Diazadithiacrown Ethers Containing Two 8-Hydroxyquinoline Side Arms. Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada389900.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Su, Ning, Jerald S. Bradshaw, Paul B. Savage, Guoping Xue, Krzysztof E. Krakowiak, and Reed M. Izaft. Synthesis of Novel 8-Hydroxyquinoline-Containing Diaz-18-Crown-6 Ligands and Analogues. Fort Belvoir, VA: Defense Technical Information Center, November 1999. http://dx.doi.org/10.21236/ada370492.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Zhang, Xian X., Jerald S. Bradshaw, R. T. Bronson, Paul B. Savage, and Reed M. Izatt. Preliminary Complexation Studies of Bis-(8-Hydroxyquinoline)-substituted Tetraaza-15-crown-5 with Various Metal Ions. Fort Belvoir, VA: Defense Technical Information Center, April 1999. http://dx.doi.org/10.21236/ada361705.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Bronson, R. T., Jerald S. Bradshaw, Paul B. Savage, Krzysztof E. Krakowiak, and Reed M. Izatt. Synthesis of Bis-8-Hydroxyquinoline-Armed Diazatrithia-15-Crown-5 and Diazatrithia-16-Crown-5 Ligands. Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada389716.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Bronson, R. T., Jerald S. Bradshaw, Paul B. Savage, Saowarux Fuangswasdi, and Sang C. Lee. Photophysical Properties of Bis-8-Hydroxyquinoline-Armed Diazatrithia-15-Crown-5 and Diazatrithia-16-Crown-5 Ligands. Fort Belvoir, VA: Defense Technical Information Center, April 2001. http://dx.doi.org/10.21236/ada389688.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Kawakami, J., R. T. Bronson, G. Xue, J. S. Bradshaw, and R. M. Izatt. Characterization of Bis-8-hydroxyquinoline-Armed Diazatrithia-16-crown-5 and Diazadibenzo-18-crown-6 Ligands as Fluorescent Chemosensors for Zinc. Fort Belvoir, VA: Defense Technical Information Center, June 2002. http://dx.doi.org/10.21236/ada406097.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!