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Curry, Richard James. "Luminescence characterisation of aluminium and erbium tris (8-hydroxyquinoline)." Thesis, Queen Mary, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312173.
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Knight, Cheryl Lynn. "Application of IR and NMR spectroscopy to certain complexes of 8-hydroxyquinoline and 8-aminoquinoline." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/22001.
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The IR spectra of twenty-one transition metal complexes of 8-hydroxyquinoline over the range 700 - 50 cm⁻¹ are discussed in relation to their known or inferred structures. The complexes are of three types: (a) the bis(aquo) complexes of the first row transition metal(II) ions, [M(ox)₂(H₂O)₂] (M =Mn, Fe, Co, Ni, Cu, Zn); (b) the corresponding anhydrous complexes, [M(ox)₂]n (M=Mn, Co, Ni, Cu, Zn) and (c) the complexes of the metal(III) ions, [M(ox)₃] (M = Sc, V, Cr, Mn, Fe, Co, Ga, Rh and In). Deuterated 8-hydroxyquinoline was. synthesized by the Skraup synthesis and has been used to assist in the assignment of the metal-ligand modes. The assignment of these bands was further based on ⁶⁴,⁶⁸Zn labellihg of the bis(aquo) zinc chelate and on the effects of metal ion substitution in relation to structural considerations based on crystal field theory. An investigation of the IR spectra of a series of -tris, bis and mono(8-aminoquinoline) complexes of the first transition row metal(II) perchlorates and halides is reported.
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Pretorius, Alet. "A preliminary investigation of the potential anticancer properties of 8-hydroxyquinoline derivatives." Diss., University of Pretoria, 2011. http://hdl.handle.net/2263/24884.
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Derivatives of the quinoline moiety have been shown to exert a range of biological activities, including anti-neoplastic activity. The clinical application of quinoline derivatives in the treatment of malignancies has been limited due to non-selectivity. Four novel hydroxyquinoline derivatives were synthesised as potential anticancer agents. Each of these compounds contains the characteristic quinoline nucleus: a heterocyclic moiety containing a nitrogen atom. A hydroxyl group is present on C-8 and an azo bond links the heterocyclic quinoline core to a monocyclic benzene ring with various substituents. The aim of this study was to investigate the potential anticancer properties of the four hydroxyquinolines as pertains to their in vitro cytotoxicity, ability to circumvent multidrug resistance and possible mechanism of action. The acute in vivo toxicity profile of the two most promising compounds was also investigated. The tumour specificity of a compound is an indicator of the selective cytotoxicity of a compound towards cancer cells, while maintaining minimal toxicity towards normal cells. To this end the four hydroxyquinolines were screened on a range of commercially available cancer cell lines and primary (normal) cultures. The cancer cell lines used included human cervical adenocarcinoma (HeLa), human estrogen receptor positive breast cancer (MCF-7) and several resistant cancer cell lines. Chicken embryo fibroblasts and human lymphocytes were included as primary cell cultures. From the results the cancer cell lines most sensitive to each compound were identified: breast (MCF-7) and leukaemia (Jurkat) cells were most sensitive to HQ5, a resistant colon cancer cell line (COLO 320DM) was most susceptible to HQ6 and HQ7, and HQ10 was most effective against cervical cancer (HeLa). Data indicated that HQ5 and HQ10 displayed the highest tumour specificities and these two promising hydroxyquinoline derivatives were selected for further investigation. As quinoline derivatives have been reported to modulate multidrug resistance through the inhibition of the P-glycoprotein (P-gp) efflux pump, the effect of HQ5 and HQ10 on P-gp was evaluated in two experimental models. Firstly the experimental hydroxyquinolines were used in combination with the P-gp substrates doxorubicin, vinblastine and paclitaxel on three P-gp expressing cell lines to ascertain whether a synergistic combination could be observed. Secondly the direct effect of HQ5 and HQ10 on the function of P-gp was determined through the rhodamine 123 retention assay. According to the results obtained from the combination therapy, the combinations of the experimental compounds and the known chemotherapeutic agents tested were at most additive. Data obtained from the rhodamine 123 accumulation assay revealed that HQ5 and HQ10 did not inhibit P-gp in the three P-gp expressing cell lines tested but appeared to enhance P-gp activity. The mechanism of action of the two selected hydroxyquinolines was further investigated through flow cytometric analysis. The effect of HQ5 and HQ10 on the induction of apoptosis or necrosis in MCF-7 cells was determined. Results indicated that the two experimental compounds induced apoptosis in a dose and time dependent manner. After investigating the effect of the hydroxyquinolines on the cell cycle progression of MCF-7 cells, it was observed that HQ5 and HQ10 arrested the cell cycle at the G1 checkpoint. Results suggest that at higher concentrations of HQ5 inhibition resembled a G2 inhibitor. In an acute in vivo cytotoxicity study the tolerability and safety profile of HQ5 and HQ10 were investigated. After daily intraperitoneal administration of either of the two compounds at two concentrations, no obvious histological signs of toxicity were reported. However a dose of 2 mg/kg per day of HQ10 caused a significant reduction in body weight. Haematological analysis revealed that administration of 0.1 mg/kg of HQ5 resulted in a significant decrease in white cell count. No other haematological parameters studied showed any difference between the animals in the control and experimental groups. It was thus concluded that daily dosing of HQ5 and HQ10 was well-tolerated and caused no severe toxicity. Chronic in vivo toxicity profiles were not determined in this study. The in vitro studies suggested that HQ5 and HQ10 displayed promising anticancer properties. However, further investigation revealed several unfavourable characteristics, with regards to the solubility, purity and stability of these experimental hydroxyquinolines. In addition in vivo studies added further doubt on the success of these compounds in a clinical setting and it was concluded that these compounds were unsuitable for further development. CopyrightDissertation (MSc)--University of Pretoria, 2011.
Pharmacology
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Tarverdi, Karnik. "Preparation and testing of lanthanum and neodymium with 8-hydroxyquinoline as potential biocide." Thesis, Brunel University, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332067.
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McDonald, F. Crisp. "The study of 8-Hydroxyquinoline-2-Carboxyllic acid and its metal ion complexing properties /." Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/mcdonaldf/fcrispmcdonald.pdf.
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Vu, Thi huyen. "Synthesis and Development New 8-Hydroxyquinoline Derivatives for the Treatment of Chlamydia trachomatis Infection." Thesis, Université de Paris (2019-....), 2020. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=4392&f=28906.
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Chlamydia trachomatis, une bactérie à Gram négatif, est responsable, à la fois, de l'infection bactérienne sexuellement transmissible la plus diagnostiquée dans le monde et du trachome, une cause importante de cécité. Aucun vaccin n'est disponible mais deux antibiotiques (Azithromycine, Doxycycline) sont recommandés par l'Organisation Mondiale de la Santé. Toutefois, un échec du traitement est signalé chez 10 à 20% des patients et résulte probablement d'un manque de sensibilité des formes persistantes de la bactérie et des modestes concentrations intracellulaires des médicaments conventionnellement prescrits. Pour ces raisons, l'objectif de ma thèse était de proposer de nouveaux outils de lutte l'infection à C. trachomatis tels que de nouveaux dérivés de la 8-hydroxyquinoléine actifs contre cette bactérie. J'ai, tout d’abord, synthétisé de nouvelles molécules et évalué leur activité anti-chlamydiale ainsi que leurs propriétés chélatantes du fer. Le composé 1 résulte du couplage de l'acide 8-hydroxyquinoléine-2-carboxylique et de la Ciprofloxacine (Cip), un antibiotique actif contre C. trachomatis. Nous voulions obtenir des dérivés plus actifs que l'antibiotique-parent par ses propriétés chélatantes de métaux et son effet antibiotique. Le composé 1 présente effectivement une activité anti-chlamydiale plus élevée que la Cip mais cet effet ne semble pas lié à ses propriétés chélatantes du métal. En modifiant certains paramètres physicochimiques tels que la lipophilie, nous avons synthétisé plusieurs dérivés du composé 1. Nous avons également préparé un conjugué d'acide folique pour permettre sa délivrance aux cellules infectées via le récepteur de ce dernier. Tous les composés obtenus sont plus actifs que la Ciprofloxacine, l'un d'entre eux atteignant une activité au nanomolaire contre la bactérie.Dans la deuxième partie, nous avons étudié l'influence de la position du carbonyle sur les propriétés chélatantes du fer de la 8-hydroxyquinoléine. Pour cela, nous avons effectué une étude mixte expérimentale (synthèse organique, spectrophotométrie et calorimétrie de titrage isotherme) et théorique (théorie de la densité fonctionnelle). Deux dérivés esters de 8-hydroxyquinoléine, en position 2 et position 7, ont été synthétisés et les complexes de fer correspondants ont été étudiés. Nous avons démontré que selon la position du groupe attracteur d’électrons sur le squelette hétérocyclique, l'encombrement stérique peut déstabiliser le complexe de fer (III) en le forçant à adopter une structure déformée, éloignée de l'environnement octaédrique idéal.Dans la dernière partie, j'ai synthétisé et caractérisé des Carbone dots (CDs) d’acide folique et de Ciprofloxacine, comme nouveaux nano-objets pour cibler les cellules infectées et inhiber la croissance bactérienne. Les deux populations de CDs ont une taille de 4 à 5 nm, émettent en lumière bleue et présentent un comportement fluorescent indépendant de l'excitation. L’efficacité antibactérienne de ces nanoparticules est actuellement en cours d’étudeChlamydia trachomatis, a Gram-negative bacterium, is responsible for both the most common sexually transmitted bacterial infection in the world and trachoma, an important cause of blindness worldwide. No vaccine is available but antibiotics (azithromycine, doxycycline) are recommended by the World Health Organization. However, treatment failure is reported 10-20% of patients and probably results from a lack of sensitivity of persistent forms of bacteria and modest intracellular concentrations of the conventionally prescribed drugs. For this reasons, the aim of my thesis was to propose new tools to fight C. trachomatis infection such as novel 8-hydroxyquinoline derivatives active against this bacterium.In the first part, I synthesised new compounds and evaluated their anti-chlamydia activity as well as their iron-chelating properties. Compound 1 results from the coupling of 8-hydroxyquinoline-2-carboxylic acid and Ciprofloxacin (Cip), a commercially available antibiotic. We wanted to obtain more active derivatives than the parent antibiotic through its metal-chelating properties and its antibiotic effect. Compound 1 presents a higher antichlamydia activity than Cip but this antibacterial effect seems not be linked to its iron-chelating properties. Modifying physicochemical parameters such as lipophilicity, we synthesized several derivatives. We also prepared a folic acid conjugate to enable its delivery to the infected cells through folic acid receptor. All compounds are more potent than Ciprofloxacin, one of them reaching nanomolar potency against C. trachomatis.In the second part, I studied the influence of the carbonyl position on the iron-chelating properties of the 8-hydroxyquinoline heterocycle. For this purpose, we performed a mixed experimental (organic synthesis, spectrophotometry and isothermal titration calorimetry) and theoretical (density-functional theory) study. Two 8-hydroxyquinoline ester-derivatives, at 2-position and 7-position, were synthesized and the corresponding iron-complexes were investigated. We demonstrated that according to the position of the withdrawing group on the heterocyclic skeleton, the steric hindrance can destabilize the iron(III) complex by forcing it to adopt a distorted structure far from the ideal octahedral environment.In the last part, I synthesized and characterized Carbon dots (CDs) from folic acid and Ciprofloxacin as new nano-tools to target the infected cells and inhibit the bacterial growth. Both populations of CDs have a 4-5 nm size, emit in blue light and present an excitation-independent fluorescent behaviour. These nanoparticles are actually under biological investigation
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Joaquim, Angélica Rocha. "Síntese de derivados de 8-hidroxiquinolina e avaliação da atividade antimicrobiana." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/181465.
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A prospecção e síntese de novos derivados de 8-hidroxiquinolina está em ascensão devido às suas diversas atividades biológicas. Neste trabalho é relatada a síntese e avaliação da atividade antimicrobiana de novos derivados contendo uma sulfonamida substituída na posição 5 da 8-hidroxiquinolina ou um grupamento aminossubstituído na posição 7 da 5-cloro-8-hidroxiquinolina ou 5-cloro-8-metoxiquinolina. Os derivados 5-sulfonamidas foram preparados por clorossulfonação seguida da reação com a amina apropriada. Os derivados 7-aminossubstituído foram sintetizados através da metilação da hidroxila da posição 8, seguida da reação de cross-coupling catalisada por paládio e desmetilação. A avaliação da atividade antimicrobiana foi realizada através do método de microdiluição em caldo. Dentre os compostos sintetizados, 5a (da série 5-sulfonamidas) foi o mais potente, sendo ativo contra todas as espécies fúngicas testadas, além de apresentar importante atividade contra cepas de Staphylococcus aureus, e baixa toxicidade contra células VERO. Isso sugere que a introdução de um grupamento retirador de elétrons em para no substituinte arila da posição 5 é importante para a atividade antimicrobiana. Ainda, a nanoemulsão preparada contendo 5a manteve a atividade antifúngica da substância contra espécies de Candida spp. A série 7-aminossubstituído também apresentou resultados muito interessantes. Desta série, o composto 5i foi o mais potente. Isso sugere que grupamentos heterocíclicos hidrofílicos na posição 7 podem favorecer a atividade antifúngica. A presença da hidroxila livre na posição 8 parece ser essencial para a atividade antifúngica, pois os derivados protegidos por uma metila foram pouco ativos. Os derivados de 8-hidroxiquinolina 5a e 5i podem ser considerados para estudos posteriores na busca de novos agentes antimicrobianos.The synthesis and screening of new 8-hydroxyquinoline derivatives is growing, due to their various biological activities. In this work, the synthesis and antimicrobial evaluation of new derivatives containing a substituted 5-sulfonamide in the 8-hydroxyquinoline or a substituted amino group at the 7-position of the 5-chloro-8-hydroxyquinoline or 5-chloro-8-methoxyquinoline is reported. The 5-sulfonamide derivatives were prepared by chlorosulfonation followed by the reaction with the appropriate amine. The 7-amino derivatives were synthesized by methylation of the 8-hydroxyquinoline, followed by palladium-catalyzed cross-coupling reaction and demethylation. The antimicrobial evaluation was tested by the broth microdilution method. Among all the prepared compounds, 5a (from the 5-sulfonamide series) was the most potent, being active against all the fungal species tested, while also showing important activity against Staphylococcus aureus strains, and low toxicity against VERO cells. This suggests that the introduction of an electron-withdrawing group at para-position of the N-aryl substituent is important for the activity. In addition, the prepared 5a nanoemulsion maintained the antifungal activity of the compound against Candida spp. The 7-amino series has also presented interesting results. In this series, 5i was the most potent compound. This suggests that the hydrophilic heterocyclic substituent at the 7-position was favorable to antifungal activity. The presence of the free hydroxyl at the 8-position is important for the antifungal activity, since the methyl-protected derivatives were poorly active. The 8-hydroxyquinoline derivatives 5a and 5i may be considered for further studies in the search for novel antimicrobial agents.
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Gregušová, Michaela. "Modifikace techniky difúzních gelů (DGT) pro charakterizaci přírodních systémů." Doctoral thesis, Vysoké učení technické v Brně. Fakulta chemická, 2010. http://www.nusl.cz/ntk/nusl-233319.
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Diffusive gradient in thin film technique (DGT) represents a relatively new approach for in situ determinations of labile metal-species in aquatic systems. The DGT device passively accumulates labile species from the solution while deployed in situ, and therefore contamination problems associated with conventional collection and filtration procedures are eliminated. This study deals with a possible modification of DGT technique. The key of using DGT technique for speciation analysis of metals is to find out suitable binding phase and diffusion layer. The new resin gel based on Spheron Oxin (5 sulphophenyl-azo-8-hydroxyquinoline) ion exchanger with a higher selectivity to trace metals than Chelex 100 could potentially provide more information on metals speciation in aquatic systems. The performance of this new binding phase was tested for the determination of Cd, Cu, Ni, Pb and U under laboratory conditions. The hydrogel layer based on poly(2-hydroxyethyl methacrylate) was synthesized and tested as a new diffusion gel for application in DGT technique.
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Aprahamian, Vicken Haroutiun. "The behaviour and control of impurities during the solvent extraction of platinum metals with an alkylated 8-hydroxyquinoline /." Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61135.
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In order to understand and control the deportment of common impurity elements in the Pt(IV)-Pd(II)-HCl-8-hydroxyquinoline (TN 1911)$ sp{ rm a}$ system, their solvent extraction chemistry in chloride solution has been studied. The investigated elements were Fe(III), Cu(II), Ni(II), Zn(II), Pb(II), Sn(IV), Ag(I), As(V), Sb(V), Bi(III), Se(IV) and Te(IV). Extraction experiments carried out using multi-element and single element feed solutions helped to elucidate the extraction behaviour of the elements with the extractant TN 1911. From the collected data it was deduced that the majority formed anionic chlorocomplexes and extracted via the ion-pair mechanism involving the protonated extractant. Consequently, scrubbing procedures were developed to control the deportment of these elements. These scrubbing steps were then incorporated into a tentative flowsheet which was simulated in a batch-wise fashion in the laboratory. The most contaminating elements were found to be Zn(II), Pb(II), Ag(I), Te(IV), Se(IV) and Bi(III). The first five were effectively scrubbed with 2.0M HCl whereas Bi(III) could only be scrubbed with 2.0M H$ sb2$SO$ sb4$ at A/O ratios of $>$3:1. The element Sn(IV) which was found to build-up in the organic, could only be scrubbed with a 1.0M NaOH solution for long contract times (60 minutes). ftn$ sp{ rm a}$A proprietary alkylated derivative of 8-hydroxyquinoline (Schering Berlin AG).
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AVILA, HAROLD JOSE CAMARGO. "DEVELOPMENT AND CHARACTERIZATION OF ORGANIC ELECTROLUMINESCENT DEVICES (OLEDS) BASED ON NEWS TETRAKIS 8-HYDROXYQUINOLINE OF RARE-EARTH COMPLEXES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2012. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=20308@1.
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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIROCOORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
PROGRAMA DE SUPORTE À PÓS-GRADUAÇÃO DE INSTS. DE ENSINO
O Alq3 é um dos mais importantes semicondutores orgânicos utilizados como transportador de elétrons e emissor em dispositivos eletroluminescentes (OLEDs). Este trabalho apresenta o estudo das propriedades ópticas, eletroquímicas, elétricas e morfológicas de três complexos baseados em íons de terras raras (TR) ligados à 8-hidroxiquinolina (q), Li[TR(q)4] (TR igual a La3mais, Y3mais e Lu3mais). Os espectros de absorção na região UV-Vis possuem máximos em 382nm para os complexos de Y3mais/La3mais e em 388nm para o complexo de Lu3mais. Os espectros de fotoluminescência dos complexos correspondem à emissão da (q) e não exibem as linhas características de emissão dos íons de terras raras. Os dados de analise térmica indicam que os complexos são termicamente estáveis até 325 graus Celsius e que apresentaram H2O absorvida da atmosfera. Os OLEDs fabricados e caracterizados neste trabalho foram de dois tipos: bicamadas e multicamadas.A1)ITO/NPB(25nm)/Li[TR](q)4](40nm)/Al(120nm);A2)ITO/NPB(25nm)/[Eu(DBM)3phen](20nm)/BCP(10nm)/Li[TR(q)4](20nm)/Al(120nm). Os OLEDs bicamadas apresentaram, em seus espectros de eletroluminescência, as bandas de emissão da (q) entre 520 ate 540nm. Os OLEDs multicamadas foram fabricados para testar a eficácia dos complexos Li[TR(q)4] como camadas transportadoras. Este trabalho evidenciou uma interessante dependência entre o pico máximo da emissão eletroluminescente e o raio iônico dos íons de TR. Os OLEDs baseados nos complexos Li[TR(q)4] apresentaram boas características quando comparadas com os OLEDs baseados Alq3, mostrando-se compostos promissores para o desenvolvimento de dispositivos orgânicos.
The Alq3 is one of the most important organic semiconductors used as electron transporting and emitting material in organic electroluminescent devices (OLEDs). This work presents the investigation of the optical, electrochemical, electrical and morphological properties of three complexes based in ions of rare earth (RE) coordinated to 8-hydroxyquinoline (q), Li[RE(q)4] (RE equal La3more, Y3more and Lu3more). The UV-Vis absorption spectrum present the maximum absorption at: 382nm for Y3more/La3more complexes and 388nm for the Lu3more complex. The photoluminescence spectra of the complexes correspond to the emission of the (q) and does no exhibit characteristic lines of the rare earths ions. The thermal analysis data indicate that the complexes are thermally stable until 325 Celsius degrees and that showed H2O molecules absorbed from the atmosphere. The fabricated and characterized OLEDs in this work were of two types: bilayer and multilayer.A1)ITO/NPB(25nm)/Li[TR(q)4](40nm)/Al(120nm);A2)ITO/NPB(25nm)/[Eu(DBM)3phen](20nm)/BCP(10nm)/Li[TR(q)4](20nm)/Al(120nm). The bilayer OLEDs showed, in their electroluminescence spectra, the emission bands of the (q) between 520 until 540nm. The multilayer OLEDs were fabricated to test the efficiency of the complexes Li[TR(q)4] as transport layers. This work showed an interesting dependence between the EL emission peak and the ionic radius of the of RE ions. The OLEDs based on the Li[RE(q)4] complexes presented good characteristics when compared to the OLEDs based on Alq3, showing as promising compounds to the organic devices development.
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Wu, Qingguo. "Luminescent organic and organometallic compounds based on 7-azaindole, 2,2'-dipyridylamine, 8-hydroxyquinoline and derivatives and their electroluminescent applications." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0010/NQ52866.pdf.
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Zhang, Hongtao. "Organic spin valves : hole injection from ferromagnetic materials into tris-8-hydroxyquinoline (Alq3) in the presence of interface states." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9080.
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This thesis presents the result of the charge carrier injection and the subsequent transport from ferromagnetic material into organic semiconductor in the Alq3 based organic spin valves. In order to study the dominant charge carrier polarity in the Alq3 based spin valves, a number of single (Alq3) layer and double (Alq3 and N,N’-bis(3-methylphenyl)-N,N’- diphenylbenzidine (TPD)) layer organic semiconductor diode devices are constructed using both conventional electrode materials as well as ferromagnetic electrodes. Single layer devices are characterised by time of flight (ToF) and dark injection (DI) transient techniques with or without ferromagnetic anodes. Double layer devices are characterised using current-voltage-luminescence (j-V-L) measurements with or without ferromagnetic cathodes. Despite Alq3 being considered an electron transport material, we measure long range hole transport within the devices with matched electron and hole mobility at large electric fields. The substitution of a conventional Al cathode with a ferromagnet drastically suppresses electroluminescence in double layer devices, due to poor electron injection from the large work function ferromagnet. DI measurements using a ferromagnetic anode display characteristic charge trapping consistent with the presence of hybridized interface states (HINTS) between anode and organic semiconductor. The temperature dependent DI and ToF measurements demonstrate a reduced hole injection barrier in the presence of the HINTS in the ferromagnetic/organic interface that enables Alq3 based organic spin valves operate at small bias. We conclude that the dominant charge carriers in Alq3 based spin valves are holes, contrary to conventional wisdom, and that hole injection under small bias conditions is aided by HINTS.
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Rahier-Corticchiato, Renaud. "Caractérisation biochimique des phospholipases D et de leurs domaines fonctionnels : nouvelle méthode de mesure de l’activité phospholipase D." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1292/document.
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La phospholipase D (PLD) hydrolyse les phospholipides membranaires en libérant leur tête polaire afin de générer l'acide phosphatidique (PA), impliqué dans la signalisation cellulaire. Pour comprendre les propriétés biochimiques des PLDs, les travaux présentés ont été réalisés autour de deux axes. Le premier axe concerne l'expression recombinante et la purification de la PLDa d'Arabidopsis thaliana (AtPLDa) dans la levure Pichia pastoris. La détermination de la séquence N-terminale a révélé que l'AtPLDa est amputée de ses 35 premiers résidus, suggérant ainsi la participation d'un mécanisme de maturation. Cependant, la région N-terminale des PLDs de plantes est homologue au domaine C2, impliqué dans leur interaction Ca2+-dépendante avec la membrane. Afin d'évaluer l'impact d'un tel clivage, les domaines C2 de l'AtPLDa mais également de l'AtPLDß, à titre de comparaison, ont été étudiés sous leur forme entière ou mature. Ainsi, la caractérisation de leur affinité pour les phospholipides, associée à leur modélisation tridimensionnelle, ont permis de démontrer que les différences de régulation par le Ca2+, observées entre les formes entières et mature, provenait de la présence d'une hélice a amphipathique, retirée lors du processus de maturation. Le second axe concerne le développement d'une nouvelle méthode de mesure des activités PLD via le dosage de manière direct, spécifique et continu du PA grâce à la propriété d'amplification de fluorescence par chélation de la 8-hydroxyquinoléine, en présence de Ca2+. Ainsi, ce test apparait adapté pour le suivi de l'inhibition des PLDs et pour l'étude de leur spécificité de substrat, en utilisant des phospholipides naturels avec différentes tête polaires, et à l'échelle d'une microplaquePhospholipase D (PLD) hydrolyses membrane phospholipids, leading to the formation of free polar headgroup and phosphatidic acid releasing, involved in cell signaling. To understand the biochemical properties of PLDs, this work has been made around two axes. The one first concerns the recombinant expression and purification of the PLDa of Arabidopsis thaliana (AtPLDa) in the yeast Pichia pastoris. The N-terminal sequence of the recombinant AtPLDa has been determined and found to lack its first 35 amino acids, suggesting the involvement of a maturing mechanism. However, plant PLDs exhibit a C2-lipid binding domain at their N-terminal region, which is involved in their Ca2+-dependent membrane targeting. Thus, to assess the impact of such a cleavage, whole and mature-like C2 domains of AtPLDa, as well as of AtPLDß, for the sake of comparison were studied. Thus, the characterization of their affinity for phospholipids, combined with their three-dimensional modeling have demonstrated that the differences observed in their regulation by Ca2+, observed between whole and mature-like forms, originated from the presence of a N-terminus amphipathic a helix, removed during the maturation process. The second axis concerns the development of a novel PLD assay that measure PA in a direct, specific and continuous manner, using the chelation enhanced fluorescence property of 8-hydroxyquinoline in the presence of Ca2+. Thus, this assay appears suitable for monitoring both the inhibition of PLDs as well as their substrate specificity, using natural phospholipids with different polar headgroups, and at a microplate scale
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Holubová, Zuzana. "Fluorimetrické stanovení skandia." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2008. http://www.nusl.cz/ntk/nusl-216411.
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The submitted thesis deals within the sensitive fluorimetric determination of scandium with a new reagent 8-Hydroxyquinoline-5-sulphonic acid. All important factors such as time, pH, reagent concentration, buffers, surfactants and selected interferents have been studied with respect to the selectivity, sensitivity, precision and detection limit on the determination by using classic fluorescence spectra and their first derivation. This reagent was also used for the determination of scandium in real waters. The new reagent was shortly compared to morin and lumogallion when used for scandium.
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Rose-Hélène, Maureen. "Aspects thermodynamiques et cinétiques de la complexation de cations métalliques (Cu²+ et Ni²+) par la 5-phénylazo-8-hydroxyquinoline (5Ph8HQ) et le cyclame greffés sur des nanoparticules de silice en suspension colloïdale." Thesis, Nancy 1, 2011. http://www.theses.fr/2011NAN10060/document.
Full textAbstract:
Nous avons considéré autant les aspects thermodynamiques que cinétiques de la complexation d'ions métalliques (Cu2+ et Ni2+) par la 5-phénylazo-8-hydroxyquinoline (5Ph8HQ) et le cyclame greffés sur des nanoparticules de silice en dispersion colloïdale. Les silices pyrogénées, caractérisées par des surfaces spécifiques respectives d'environ 200 et 390 m2/g, ont été sélectionnées avec l'objectif d'obtenir des suspensions colloïdales stables. Nous avons démontré l'aptitude des colloïdes obtenus à extraire des cations divalents à l'état de traces (de l'ordre du micromolaire). Nous avons eu recours à l'ultrafiltration pour séparer la phase silicique dispersée de la phase aqueuse. Nous avons également montré l'intérêt de remplacer une pseudophase micellaire solubilisant l'extractant par nos phases solides. Nous avons décrit les cinétiques de complexation en utilisant la technique de la spectrophotométrie à écoulement bloqué pour les réactions les plus rapides. La dépendance de la constante de vitesse observée vis-à-vis de la concentration en cation métallique, du contre-ion considéré (acétate ou chlorure), de la force ionique et du pH a été évaluée. Pour décrire la cinétique de réaction du Ni2+ avec la 5Ph8HQ greffé, il nous a fallu prendre en compte les propriétés spectrophotométriques du complexe sur nanoparticules de silice. C'est un comportement original de la 5Ph8HQ sur silice puisque les densités optiques de solutions contenant la 5Ph8HQ en milieu micellaire ou le cyclame greffé sur silice suivent la loi de Beer-Lambert. L'étude du cyclame greffé qu'il s'agisse des cinétiques ou à l'équilibre est compliquée en raison du relargage de ce dernier en solutionWe considered both the thermodynamic and kinetic aspects of metal ions (Cu2+ and Ni2+) complexation by 5-phenylazo-8-hydroxyquinoline (5Ph8HQ) and cyclam grafted onto silica nanoparticles in colloidal dispersion. Fumed silicas with specific areas of respectively 200 and 390 m2/g were selected to get stable colloidal suspensions. We demonstrated the ability of these colloids to extract trace elements (at micromolar level). We used the ultrafiltration process to separate the dispersed silica phase from the aqueous phase. We also showed interest of our solid dispersed phases instead of a pseudo micellar one. We described complexation kinetics by stopped flow technique for the fastest reactions. The influence of metal cation concentration, counter-ion nature (acetate or chloride), ionic strength and pH on observed rate constant has been investigated. To describe the Ni2+ kinetics with grafted 5Ph8HQ, we took into account the spectrophotometric properties of the complex on silica nanoparticles. This is an original behaviour of 5Ph8HQ on silica since the optical densities of solutions containing 5Ph8HQ solubilised in micelles or cyclam grafted onto silica follow the Beer-Lambert's law. The study of grafted cyclam whether the kinetics or equilibrium is complicated due to the release of the latter in solution
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Benaissa, Tahar. "Synthèse de ligands contenant un atome de fluor et pouvant donner des complexes à applications médicales : étude de la complexation de la 5-fluoro-8-hydroxyquinoline avec des cations métalliques, par RMN du fluor." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10100.
Full textAbstract:
Ce travail se place a la convergence de deux grands themes etudies au laboratoire: le marquage de molecules par un atome de fluor et l'etude de la complexation de cations metalliques par des ligands. La premiere partie concerne la preparation de deux series de ligands contenant du fluor: des biphenols et des composes contenant des groupements 2-fluoropyridines. Les biphenols substitues par deux ou quatre atomes de fluor (en position 4,4' ; 5,5' ; 4,4 ;,5,5') ont ete obtenus a partir de bromophenols par une reaction de type ullman. Leurs derives sulfones ont egalement ete prepares pour augmenter la solubilite dans l'eau. Les ligands de la seconde serie, tel la n,n,n',n' tetrakis(6-fluoro-2-pyridylmethyl)ethylenediamine, ont ete obtenus par alkylation de differentes amines avec la 2-fluoro-6-bromomethylpyridine, dans des conditions de transfert de phase. Ces ligands ont ete caracterises par rmn du #1h, #1#9f et #1#3c et des resultats interessants, concernant les constantes de couplage, ont ete observes. Ces deux familles de ligands ont ete prepares afin de permettre, par la suite, une etude de leur complexation par rmn du #1#9f, analogue a celle entreprise dans la partie suivante. La seconde partie concerne l'etude de la complexation de la 5-fluoro-8-hydroxyquinoline (fox) avec des cations metalliques (le gallium et le fer) par rmn du #1#9f et par spectroscopie uv-visible. Concernant l'etude de la complexation de ga par la fox utilisant la rmn du fluor nous avons constate que les trois complexes gafox, gafox#2 et gafox#3 ont des deplacements chimiques du fluor differents, obtenu les diagrammes de repartition des especes en fonction du ph pour differents rapports molaires c#m/c#f#o#x (c#m et c#f#o#x sont les concentrations en metal et ligand) et calcule les trois constantes de formation des complexes gafox, gafox#2 et gafox#3. Le complexe gafox#3 a egalement ete etudie seul en solvant organique (dmf-d7). Nous avons mis en evidence que dans ce complexe, qui existe presque uniquement sous la forme de l'isomere mer, les trois ligands subissent une interconversion intramoleculaire rapide
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Odhar, Hasanain. "Identification of novel scaffolds for Monoamine oxidase B inhibitors." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1394416913.
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Zhang, Sijie. "Modelling of organic magnetoresistance in aluminium tris(8-hydroxyquinolinate) light emitting diodes." Thesis, Queen Mary, University of London, 2012. http://qmro.qmul.ac.uk/xmlui/handle/123456789/2519.
Full textAbstract:
This thesis concerns itself with the scientific study of the modelling of organic magnetoresitance (OMR). This can be divided into two parts: the magnetic field effects on the intersystem crossing (ISC) in organic semiconductors, and the modelling of OMR, including triplet polaron interactions (TPI). In my studies of the magnetic field effect on photoluminescence (PL), the ISC rate, kISC, is estimated by modelling the dependence of the PL under high excitation intensity. Using a modified rate model, a kISC of 2.3 x 104s-1 is derived at a temperature of 80K in Alq3. An excited state absorption (ESA) mechanism was also proposed to help understand how the ISC can occur from higher excited triplet states to the singlet state, rather than just from the singlet to a lower lying triplet state. This is necessary as the measured activation energy from the transfer from T1 to S1 is only 15±5meV. In addition, the effect of a magnetic field on photoluminescence intensity for Alq3 is reported, in order to explain the change in the kISC caused by an applied magnetic field. The magnetic field may affect the mixing of a pair state prior to exciton formation as well as the exciton itself. I then present the modelling of OMR as a function of device thickness. Here, a TPI model is proposed to fit the OMR data. For all Alq3 devices of any thickness, the OMR data can be modelled using just three processes: triplet dissociation, polaron trapping and TPI. Both the sum of prefactors for dissociation and trapping (ad+ at), and the prefactor for TPI, ai, are proportional to the exciton concentration within the device, over the full range of operating conditions. This is the first time that a predictive model of OMR has been developed. This model is then extended to fit the OMR data as a function of temperature. In addition, I discuss some surprising phenomena at low temperature, such as a delay between the onset of light emission and the onset of OMR, and the decrease in the percentage efficiency change with the effect of a magnetic field.
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Silva, Antonio Tarciso Ciríaco da. "Manejo pós-colheita de Alpinia purpurata (Vieill) K. Schum (Zingiberaceae)." Universidade Federal de Alagoas, 2006. http://repositorio.ufal.br/handle/riufal/197.
Full textAbstract:
The growth of ornamental plant market in Brazil is remarkable nowadays with
strong participation of Northeast region, particularly in Alagoas State on the
commercialization of tropical flowers. Taking into account this economic aspect,
it is of great importance for the productive chain of ornamental species the
study of aspects of post harvest activities. Alpinia purpurata (Viell) K. Schum
(Zingiberaceae) which occupies the second place in economic importance
amongst tropical flowers. It is the main flower for growing and harvesting. The
main objective of this research programme is to study the different aspects of
Alpinia post-harvesting: (1) time of harvesting and cut of the basis of the stems,
and (2) the use of solutions of pulsing ; and/or maintenance of the floral stem
by using: (2.1.) biocide compounds and pH of the solution; (2.2) carbohydrates
and carbohydrates plus biocides; (2.3) anti-ethylene compounds and antiethylene
compounds plus carbohydrates; (2.4) elements as calcium and silicon;
and (2.5) senescence retarding growth regulators. It was evaluated the
influence of these factors in the water relations, quality and longevity of the
stems. Six experiments were carried out in the laboratory (CECA) of the
Federal University of Alagoas. In the first experiment, the stems were harvested
in three different times and they were cut periodically on their basis. In the
second experiment different biocide substances were tested (8-
hydroxyquinoline sulphate, aluminum sulphate, salicilic acid and sodium
hipocloride) associated to pH variation of the maintenance solution. In the third
experiment the stems received sucrose solutions pulsing from 2 to 20% for 12,
24 and 48 hours, following by maintenance in distilled water or in solution of 8-
hidroxikinolin (HQS). The fourth experiment comprised three times of exposition
(30, 60 and 120 min) with STS 1mM following by the presence or absence of
pulsing in sucrose 20% for 12 hours. In the fifth experiment it was evaluated
the effect of the addition of Ca (calcium sulphate 50 and 100mM), Si (sodium
silicate 1,25 and 2,50 mM) and Ca+Si in maintenance solution. In the sixth
experiment the stems were submitted to gibberellins, solutions (GA3), 10, 30
and 60 μm and cytokinin (benzyladenine 6-BA), 10, 20 and 100μm in 24
hours pulsing under continuous light. In all experiments the fresh biomass and
the quality (scale of values) of the stems were determined daily or every two
days until the end of the experiment. The amount of water was also determined
for the floral bracts and dry biomass. The experiments were analised by
completely randomized design and the data submitted to the variance analysis,
test of averages and , when necessary, to the regression analysis. It was
observed that the stems harvested at the end of the afternoon had shown
greater commercial value; however, the regular cuts of the basis of the stems
reduced their longevity. The use of HQS provided greater durability and
humidity of the stems. On the other hand the other biocides did not improve the
quality when compared to the control. The reduction of the pH by using citric
acid did not interfere with the studied parameters. The use of sucrose in
pulsing was only effective when the stems had been kept in distilled water. In
this case the concentration sucrose of 20% for 12 hours showed better results.
Silver thiosulphate when in pulsing for 30 minutes produced an increase of
water contents and for 60 minutes or plus, or when addition of sucrose, caused
dehydration of the stems. The only use of calcium sulphate or in association
with sodium silicate in maintenance solution caused high improvement of the
quality of the stems in comparison to the control and sodium silicate treatment.
The use of cytokinin and gibberellins even considering it improved the water
contents of the stems did not affect the commercial durability of them.É notável o crescimento do mercado de plantas ornamentais no Brasil. Com participação efetiva da região Nordeste, destacando-se as exportações de flores tropicais, onde o Estado de Alagoas vem se firmando, com Alpinia purpurata (Viell) K. Schum (Zingiberaceae) como a principal flor de corte, e que ocupa o segundo lugar em importância econômica dentre as flores tropicais. Levando-se em conta esse aspecto econômico, verifica-se ser de grande importância para a cadeia produtiva desses cultivos, o estudo de aspectos relativos à da pós-colheita. Assim sendo, a presente pesquisa, objetivou estudar diferentes aspectos do manejo pós-colheita dessas flores, testando: (1) hora de colheita e corte da base das hastes, e (2) o uso de soluções de pulsing ; e/ou manutenção das hastes florais - neste caso ainda associado (2.1) a substâncias biocidas com o pH na solução sob controle; (2.2) a carboidratos e carboidratos mais biocidas; (2.3) a substâncias anti-etileno e substâncias anti-etileno mais carboidratos; (2.4) a elementos como cálcio e silício; e (2.5) a fitorreguladores retardantes da senescência. Avaliou-se a influência destes fatores nas relações hídricas, qualidade e longevidade das hastes cortadas, através de seis experimentos em laboratório no Centro de Ciências Agrárias da Universidade Federal de Alagoas (CECA/UFAL). No primeiro experimento, as hastes foram colhidas em três diferentes horários, recebendo durante o período pós-colheita cortes periódicos na base da haste. No segundo experimento, foram testadas substâncias biocidas (Sulfato de 8- hidroxiquinolina, Sulfato de alumínio, Ácido salicílico, Hipoclorito de sódio) associadas à redução ou não do pH. No terceiro experimento as hastes receberam tratamento de pulsing com soluções de sacarose entre 2 e 20%, por períodos de 12, 24 e 48 h, seguidas de manutenção em água destilada ou em solução de 8-hidroxiquinolina (HQS) comparando-se com duas testemunhas (água destilada ou solução de HQS). No quarto experimento, foram testados três tempos de exposição (30, 60 e 120 minutos) a STS 1mM, seguido ou não de pulsing em sacarose a 20%, por 12 horas. No quinto experimento, foram verificados os efeitos da adição de Ca (sulfato de cálcio a 50 e 100mM), Si ( silicato de sódio a 1,25 e 2,50 mM) e Ca+Si em solução de manutenção. No sexto experimento, as hastes foram submetidas a soluções de SILVA, A.T.C. 2006 Manejo pós-colheita de alpinia purpurata (Vieill) K. Schum (zingiberaceae)... xv giberelina (GA3), a 10, 30 e 60 μM e citocinina (benziladenina 6-BA), a 10, 20 e 100 μM em pulsing por 24 horas, sob luz contínua. Em todos os experimentos, a massa fresca e a qualidade (com base em notas) das hastes foram determinadas diariamente, ou a cada 2 dias; no final de cada experimento foram também determinados o conteúdo relativo de água das brácteas florais e a massa seca das hastes. O delineamento utilizado foi o inteiramente casualizado sendo os dados submetidos à análise de variância, teste de médias e, quando necessário, à análise de regressão. As hastes cortadas ao final da tarde tiveram maior durabilidade comercial, porém o corte periódico da base das hastes reduziu sua longevidade. O uso de HQS proporcionou maior durabilidade e hidratação das hastes, sendo que os demais biocidas testados não melhoraram a qualidade. A redução do pH, pelo uso do ácido cítrico, não influenciou nas variáveis estudadas. O uso de sacarose em pulsing só foi efetivo quando as hastes foram mantidas em água destilada, sendo melhor o resultado para a concentração de 20% por 12 horas. O tiossulfato de prata em pulsing por 30 minutos, promoveu um aumento de hidratação, mas desidratou as hastes a 60 minutos ou mais ou quando adicionado à sacarose. O uso de sulfato de cálcio em solução de manutenção e quando associado ao silicato de sódio promoveu elevada melhoria de qualidade das hastes. O uso de citocininas e giberelinas embora tenha melhorado as relações hídricas das hastes não afetou a durabilidade comercial das mesmas.
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Kao, Fan-Hsuan, and 高凡軒. "Fabrication and Characterization of 8-Hydroxyquinoline and Tris-(8-Hydroxyquinolinate)aluminium Crystals from Physical Vapor Transport." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/99327459342214069564.
Full textAbstract:
碩士中原大學
物理研究所
99
This paper focuses on the fabrication of tri(8-hydroxyquinolinate)aluminium (Alq3) and 8-hydroxyquinoline (8Hq) crystals from physical vapor transport (PVT) method and the properties of these crystals characterized by photoluminescence (PL), UV-visible absorption spectroscopy (UV-visible), Fourier Transform Infrared Spectroscopy (FT-IR), and Powder X-ray Diffraction (XRD). First, from FTIR, PL, uv-vis, and XRD, the as-received Alq3 powder is confirmed to have meridional structure (mer-Alq3) with mixed phase, and after thermal treatment at 395℃, the facial structure (fac-Alq3) with δ-phase is obtained. Then, by using these two different source (mer-Alq3 and fac-Alq3) powders, the side-wall deposition due to constitutional supersaturation (CSS) in PVT is observed. From a control of different transport vapors (N2, O2, dry air, or wet air) inside the PVT tube with various vapor pressures (1 ~ 700 torr), the side-wall deposition of Alq3 and 8Hq are observed to occur at 100 ~ 270℃ and at room temperature, respectively. Furthermore, the deposition of Alq3 has two different crystal phases depending on the source powder. The β-Alq3 is obtained from mer-Alq3 source powder and α-Alq3 from fac-Alq3 source powder. This phenomenon can be explained by a picture associated with activated barrier crossing diagram. Finally, by using various transport gases but with a fixed pressure of 400 torr, the formation mechanism of 8Hq crystals is found to be strongly related to the content of H2O. In dry gases, needle-like 8Hq crystals are formed preferential; while in wet gases, the side-wall is compactly covered by 8Hq with short needles. The content of H2O inside the PVT tube is believed to play an important role to the dissociation of Alq3 and to the side-wall deposition of 8Hq.
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Feng, Xiaodong. "Development of 8-Hydroxyquinoline Metal Based Organic Light-emitting Diodes." Thesis, 2008. http://hdl.handle.net/1807/11202.
Full textAbstract:
Because of its potential application for flat panel displays, solid-state lighting and 1.5 µm emitter for fiber optical communications, organic light-emitting diodes (OLEDs) have been intensively researched. One of the major problems with current OLED technology relates to inefficient electron injection at the cathode interface, which causes high driving voltage and poor device stability. Making a low resistance cathode contact for electron injection is critical to device performance. This work mainly focuses on cathode interface design and engineering.
The Ohmic contact using a structure of C60/LiF/Al has been developed in electron only devices. It is found that application of the C60/LiF/Al contact to Alq based OLEDs leads to a dramatic reduction in driving voltages, a significant improvement in power efficiency, and a much slower aging process.
A new cathode structure based on metal-organic-metal (MOM) tri-layer films has been developed. It is found that MOM cathodes reduce reflection by deconstructive optical interference from two metal films. The absolute reflectance from the MOM tri-layer films can be reduced to as low as 7% in the visible light spectrum. In actual working devices, the reflectance can be reduced from ~80% to ~ 20%. MOM cathodes provide a potential low-cost solution for high contrast full-color OLED displays.
Low voltage Erq based OLEDs at 1.5 µm emission have been developed. The Erq/Ag cathode interface has been found to be efficient for electron injection. Dramatic improvement in driving voltage and power efficiency has been realized by implementing Bphen and C60 into Erq devices as an electron transport layer. Integration of Erq devices on Si wafers has also been demonstrated.
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Lee, Yu-Ping, and 李育凭. "Synthesis, Characterization and Properties of 8-Hydroxyquinoline-Containing Rhenium Complexes." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/4gxb72.
Full textAbstract:
碩士國立臺北科技大學
化學工程研究所
97
Nine rhenium organometallic complexes were synthesized under solvothermal reaction conditions. These complexes were dlassified into two parts for studing. In part I focus on the cross-coupling of unactivated arenes with rhenium complexes. In this part four dirhenium organometallic complexes [(CO)3Re(L)]2 (1—4) were synthesized by using 8-hydroxyqunoline and quinoxaline derivatives under solvothermal reaction condition. Among then there were two ligands exhibited the unprecedented cross-coupling reaction of unactived arenes. To our best knowledge, this is the first report of rhenium joined dehydrogenative cross-coupling between two different ligands with unactivated arenes. And in part II of this thesis is to study the 8-hydroxyquinoline containing mono and binuclear rhenium complexes. Five rhenium organomatellic complexes were successful synthesized under hydrothermal reactions and characterized. These complexes could be simply classified as monorhenium complexes and dirhenium-containing complexes. Their electrochemical and photophysical properties have been examined. In our preliminary research, the calculated comproportionation constant shown the stability of complex [{(CO)3Re}2(C9H7NO)2(C10H8N2)] (5) (KC = 1.98 × 105) in electrochemistry. From photophysical examining showed that the luminosity of three mononuclear complexes (7—9) at 500 nm will change with the variate of concentration of HCl in solutions.
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Hu, Chih-Chin, and 胡智欽. "The Synthesis and Fluorescence of 7-substituted-8-hydroxyquinoline contained copolymer." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/14377743201769790270.
Full textAbstract:
碩士國立臺北科技大學
化學工程系碩士班
91
Synthesize carbazole and fluorine monomers that have external double bond, use the external double bond of carbazole and fluorine monomers to copolymerize with the allyl group of 7-allyl-8-hydroxyquinoline, and use these copolymers to chelate with AlCl3. So, the side chain of these copolymers is Alq3 (tris-(8-hydroxyquinoline) aluminum) complexes. There is large overlap between the emissions of either carbazole or fluorine monomers and the excitation of Alq3. In this study, we synthesize copolymer which side chain is Alq3 and discuss carbazole and fluorine monomers will transfer energy to Alq3 or not. From the experiment data, we use the excitation of either carbazole or fluorine monomers to light up the copolymer. Because of the overlap between emission of either carbazole or fluorine monomers and the excitation of Alq3, Alq3 absorb the emission of either carbazole or fluorine monomers as excitation to increase it′s emission. That proves carbazole and fluorine monomers will transfer energy to Alq3 group.
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Chang, Chun-Yi, and 張峻誼. "Synthesis of 2-Styrylchromone and 8-Hydroxyquinoline Derivatives as Anticancer Agents." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/38371500242574807026.
Full textAbstract:
碩士淡江大學
化學學系碩士班
98
The first part : A series of 2-styrylchromone analogs were synthesized and examined for their antiproliferative effects on a panel of carcinoma cells. Among the tested agents, only 34 exhibited a moderate activity with an IC50 value of 28.9 μM against PC-3 cells which indicates the selectivity of PC-3 cells in response to 2-styrylchromones. In addition, 38 demonstrated the most antiproliferative effect with an IC50 value of 4.9 μM against HeLa cells. Together, these results suggest a potential structural optimization and pharmacological study of 2-styrylchromones. The second part : A series of Mannich-type reaction of 8-hydroxyquinoline derivatives are prepared which demonstrated apoptosis-inducing effect against HeLa cervical cancer cells. Among the tested compounds, 5-nitro-7-((4-tosylpiperazin-1-yl)methyl)quinolin-8-ol (115) exhibited the most anti-proliferative effect with an IC50 value of 0.7 μM. Further structure-activity relationship (SAR) study as well as pharmacological exploitation of this novel 8-hydroxyquinoline scaffold are underway.
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Liu, Che-Hung, and 劉哲宏. "Synchrotron Radiation Photoemission Study of Ca-doped Tris(8-hydroxyquinoline)aluminum." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/87a3r5.
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ZLOJUTRO, VLADIMIR. "TRIARYLBORON-FUNCTIONALIZED 8-HYDROXYQUINOLINE AND THEIR RESPECTIVE ALUMINUM (III) AND DIBORON COMPOUNDS." Thesis, 2011. http://hdl.handle.net/1974/6737.
Full textAbstract:
The purpose of this thesis was to develop the first examples of multifunctional triarylboron-functionalized 8-hydroxyquinoline, their respective aluminum (III) complexes, Al(1)3 and Al(2)3, and diboron analogues, B1 and B2. There was particular focus in investigating the electron accepting characteristics of these systems for potential use as electron transport materials (ETMs) in organic light emitting diodes (OLEDs).
The first part of the thesis will discuss the aluminum complexes. Through the introduction of the triarylboron moiety these derivatives of the well-known ETM tris(8-hydroxyquinoline)aluminum (Alq3) exhibited better electron accepting properties than the parent compound. Furthermore, the complexes were able to act as sensors and indicators towards soft Lewis acids such as CN- and hard Lewis acids such as F-, respectively.
First the structures of the compounds were investigated using COSY NMR, leading to the discovery that similar to Alq3 the new aluminum complexes possessed the commonly observed mer-isomeric form. Furthermore, their photophysical characteristics were investigated using UV-Vis and fluorescence spectroscopic measurements. The solid state fluorescence quantum yield of Al(1)3 (Φ=0.06) and Al(2)3 (Φ=0.02) were measured and compared to Alq3 (Φ=0.14). In order to better understand these results and gain insight into the electronic transitions of the aluminum complexes, DFT calculations were employed using the B3LYP/6-31G* level of theory.
The second part of the thesis will discuss the only examples of diboron-functionalized 8-hydroxyquinoline complexes to date, with one three-coordinate and one four-coordinate boron moiety. Based on CV measurements and DFT calculations, it was discovered that the LUMO of the diboron compounds were lowered substantially compared to their aluminum analogues discussed earlier. More interestingly, it was found that only B1 has any contributions to its LUMO from the triarylboron moiety, leading to the slightly stronger electron accepting ability of B1 compared to B2. Furthermore, these compounds were both able to act as sensors towards small anions such as F-.Thesis (Master, Chemistry) -- Queen's University, 2011-09-21 08:43:10.543
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Maharaj, Vanitha. "An investigation of the complexes of zinc and germanium with 8-hydroxyquinoline." Thesis, 1991. http://hdl.handle.net/10413/5849.
Full textAbstract:
The experimental work described in this thesis is
aimed at the elucidation of the speciation of the zinc
and germanium 8-hydroxyquinoline systems. A knowledge
of this speciation could aid in modelling the kinetics
of solvent extraction of zinc and germanium with 7alkyl
derivatives of 8-hydroxyquinoline.
In this study the stability constants of the ligand 8hydroxyquinoline
with the ions H+, Zn2+ and Ge4+ have
been investigated by potentiometry at 25°C in a
partially aqueous medium. A titration technique was
used in which the hydrogen ion concentration was
monitored using a glass indicating electrode. The
partially aqueous medium comprised of O. 1 mol dm- 3
NaCl04 in 60% (v/v) dioxane and the concentration
levels of the reagents were at least millimolar. The
analysis of the potentiometric data was carried out
with the aid of the computer programs HALTAFALL, ESTA
and STATGRAPHICS.
The results obtained for the systems involving the H+
and Zn2+ ions compare with those reported in the
literature. The stability constant of a protonated
species in the zinc-8-hydroxyquinoline system (ZnLH)
was established for the first time. Precipitates
obtained from the Zn2+ titrations were identified as
zinc 8-hydroxyquinolate dihydrate.
The germanium 8-hydroxyquinoline system has not been
studied previously via potentiometry techniques. The
complex hydrolysed species of germanium in aqueous
solutions and the unusual features displayed in the
formation curves increased the complexity of species
selection. Although a suitable model of the species
present could not be determined some evidence suggests
the presence of protonated species. Hence, a
prerequisite for resolving the germanium-8hydroxyquinoline
system could be a more complete
understanding of the hydrolysis of germanium in the
partially aqueous medium used.Thesis (M.Sc.)-University of Natal, Durban, 1991.
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Lin, Hsiao-Hsuan, and 林孝軒. "Ag on Tris(8-hydroxyquinoline)aluminum interface studied by Synchrotron Radaition Photoemission." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/78830631159626224000.
Full textAbstract:
碩士國立清華大學
材料科學工程學系
93
Organic light emitting devices (OLEDs) has superiority to traditional LEDs by its low power consumption and wide viewing angle. Alq3 is the most popular material for the electron transport layer in OLED, which was constructed by three quinolines and an aluminum atom. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) of Alq3 band are located on the phenoxide site and pyridrl site on Alq3 molecule, respectively. We have focused on the interface between Alq3 and the metal cathode in this research, which dominates the barrier of electron injection from metal cathode to the organic layer. We used the synchrotron radiation to take our data and investigate the how Alq3 interact with Ag with different thickness. According to our experiment, we differentiate Ag deposition on Alq3 into two stages. In stage I, Ag atom diffuses into thick Alq3 film and causes band bending of Alq3. In stage II, the Ag dopant grows as clusters on the top of the Alq3 than diffusing into it. In the process of Ag dopant becomes more to decrease the inevitable charging effect of thick organic layer. On the other hand, the Ag donate charge to the N atom in Alq3, which forms the cluster-induced dipole with magnitude 0.24 eV. This leads us to detect the vacuum level (VL) difference between Ag and Alq3 including work function difference and cluster-induced dipole, which with magnitude 0.6eV. By the way, the large cluster size of Ag would elongate the Al - O bond and make a new component appear in O 1s spectrum.
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林煒智. "Synchrotron radiation photoemission study of potassium-droped Ag/tris(8-hydroxyquinoline) aluminum interface." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/25524608010051552403.
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Wang, Yan-Chiuan, and 王彥權. "Synchrotron radiation photoemission study of calcium-doped Ag/Tris(8-hydroxyquinoline) aluminum interface." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/79957378342505231100.
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Yen, Chia-Liang, and 顏嘉良. "Study on Explosive Detection to Application Synthesis of Bis-(8-hydroxyquinoline) magnesium (MgQ₂)." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/42552247533027814091.
Full textAbstract:
碩士國防大學理工學院
應用化學碩士班
98
In the present work, The fluorescent MgQ₂ complex, containing bis-(8-hydroxyquinoline) and magnesium(Ⅱ) was synthesized. The complexes were characterized by Fourier transform infrared Spectroscopy(FTIR), Mass Spectroscopy, Ultra-Violet Visible Spectroscopy(U.V) and Fluorescent Spectrum. In addition, the sol-gel method has been employed in the fabrication of composite sensing films consisting of bis-(8-hydroxyquinoline)magnesium, Znic oxide(ZnO) and polyvinyl -pyrrolidone(PVP). These films were examined for applications to detect explosives compounds such as 2,4,6-trinitrotoluene(TNT), picric acid(PA), styphenic acid, 2,3-dinitrotoluene(2,3-DNT), 2,6-dinitrotoluene (2,6-DNT) and 3,4-dinitrotoluene (3,4-DNT). The composite thin film showed high fluorescence quenching sensitivity towards DNT, TNT, PA and Styphnic Acid, indicating that composite sensing films consisting of emissive bis-(8-hydroxyquinoline)magnesium are potentially useful chemosensor for detecting explosives. The relative sensitivity of fluorescence quenching of emissive materials by the explosives has been rationalized in terms of the vapor pressure of the explosives, the interaction of the emissive compound and the analyles, and the relative energy levels of the emissive materials.
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"Spectrofluorimetric determination of aluminium in food and antacid drugs with 8-hydroxyquinoline as reagent." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5887797.
Full textAbstract:
by Kwong Tsz-kin.Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.
Includes bibliographical references (leaves 90-96).
Chapter I. --- Abstract --- p.i
Chapter II. --- Acknowledgment --- p.ii
Chapter III. --- Table of contents --- p.iii
Chapter IV. --- List of Tables and Figures 、 --- p.iv
Chapter Chapter 1. --- Introduction --- p.1
Chapter 1.1. --- General introduction
Chapter 1.2. --- Review of analytical methods for aluminium analysis
Chapter 1.3. --- Spectrofluorimetric determination of aluminium
Chapter 1.4. --- Project aim
Chapter Chapter 2. --- Experimental --- p.14
Chapter 2.1. --- Apparatus
Chapter 2.2. --- Reagents & Material
Chapter 2.3. --- Procedure
Chapter 2.4. --- Treatment of data
Chapter Chapter 3. --- Results and discussion --- p.24
Chapter 3.1. --- Optimization of experimental conditions
Chapter 3.2. --- Analytical Parameters
Chapter 3.3. --- Analytical results
Chapter Chapter 4. --- Conclusion --- p.89
Chapter Chapter 5. --- References --- p.90
Appendix --- p.97
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Lee, Hsin-Han, and 李欣翰. "A synchrotron radiation photoemission study of metal-doped tris(8-hydroxyquinoline) aluminum (Alq3) interface." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/77136583563600258496.
Full textAbstract:
博士國立清華大學
材料科學工程學系
98
本篇論文利用同步輻射光電子技術量測金屬/Alq3界面的電子結構，同步輻射光電子技術的優點是，藉由不同的光束線的分光儀選取不同的光能量，提高表面靈敏度。 將鹼金屬、鹼土族金屬或銀，蒸鍍到Alq3表面，量測在超高真空環境下這些金屬與Alq3介面的反應，探討有機發光二極體（OLEDs）的Alq3/陰極可能發生的反應。論文最主要的發現是一些金屬會在金屬/Alq3界面，大於鍵切臨界蒸鍍量時，會發生鍵切現象（bond-scission）。 在Cs/Alq3界面，存在一個臨界蒸鍍時間（220秒）。當蒸鍍時間大於220秒，Alq3分子鍵會被Cs原子切掉而分解，產生Alq2和Csq，Alq2 和Alq分子會更近一步地被Cs原子切掉，形成Alq和Al。 在K/Alq3界面，存在一個臨界濃度（x=2.4）。當掺入濃度大於臨界濃度時，鄰近phenoxide環的Al−O−C鍵會K原子切掉，重新形成新鍵結。Alq3分子鍵會被K原子切掉而分解，產生Alq2和Kq。同樣地，Alq2會因為Kq的形成而分解成Alq甚至Al。 在Ca/Alq3界面，存在一個臨界蒸鍍時間（4分鐘）。當蒸鍍時間大於4分鐘時，鄰近phenoxide環的Al−O−C鍵會Ca原子切掉，重新形成新鍵結。Alq3分子會被Ca原子切掉而分解，產生Alq2和Caq2。相對地，在pyridyl環產生應變的C=N−C鍵沒有被切斷。 在Ag/Alq3界面，根據Al 2p、 Ag 3d、N 1s和O 1s能譜顯示，在Ag和Alq3之間不會產生化學反應，銀的摻入只會在鄰近phenoxide環的Al−O−C鍵與鄰近pyridyl環的C=N−C鍵，產生一個應變的環境。
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Foster, Stephen James. "An investigation of the solvent extraction kinetics of Germanium by 7- alkylated.-8-hydroxyquinoline extractants." Thesis, 1990. http://hdl.handle.net/10413/5569.
Full textAbstract:
Equilibrium and kinetic data for the solvent extraction of
germanium by three impure commercial 7-alkylated-8hydroxyquinoline
extractants which vary in structure at the 7alkyl
group, are evaluated in order to elucidate an holistic
kinetic extraction model which accounts for the various
reactions and partition effects occurring during the metal-ion
chelation process.
It is proposed that for the extraction process, which is first
order in germanium concentration, by the ligand reagents
Lix 26, TN 01787 and TN 02181, the rate-determining step, on
stereochemical grounds, is the attachment of either a neutral
ligand or a protonated ligand species-to the biligand
intermediate GeL2
2+ (L:ligand) at the interface.
In high speed shaking/mixing assemblies the extraction process
was observed to occur in two discrete reaction regimes : a
fast initial rate for which the orders with respect to ligand
reagent are 1,06, 2,10 and 1,77 for TN 02181, Lix 26 and
TN 0178-7 respectively, and a slower subsequent rate for which
the apparent reaction orders with respect to ligand
concentration are 1,12, 2,70 and 3,08 for TN 02181, Lix 26 and
TN 01787 respectively. For the slower reaction regime, orders
between 1 and 3 are explicable if the steady state
approximation is invoked for the intermediate germanium
species GeL3+ and GeL2
2+ formed at the interface. In the fast
reaction regime, it is proposed that the accelerated
extraction rates are a function of (i) the speciation of
germanium and (ii) participation in the rate-determining step
by the protonated ligand moiety H2L+HS04- which is rapidly
formed after phase contact.
At low ligand concentration, the following order of ligand
efficacy has been observed :
TN 01787 < Lix 26 < TN 02181
whereas at high concentration ligand efficacies are similar
because the interface is saturated with ligand.
Orders with respect to [H+] for the reagents vary from -1 to -
3 during the course of reaction, indicating complex mixedorder
behaviour.
The effects upon extraction of ionic strength, temperature,
the addition of organic modifiers and diluent nature are
investigated as well as the kinetics of germanium stripping by
aqueous hydroxide.
The physical effects of interfacial tension, viscosity and
relative dielectric constant are also reported and suggestions
are made as to their effect upon the extraction
characteristics. Computer modelling of the extractants has
been used as an aid in describing size, structure and
stereochemical considerations of the ligands and the chelate
products.Thesis (Ph.D.)-University of Natal, Durban, 1990.
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Pellow-Jarman, Martin Vincent. "The liquid-liquid extraction of Germaniun with the 7-alkylated 8- hydroxyquinoline derivative - KELEX 100." Thesis, 1990. http://hdl.handle.net/10413/6133.
Full textAbstract:
Germanium can be extracted from aqueous solutions by
KELEX 100 dissolved in an appropriate diluent.
KELEX 100 is a commercially available chelating
extractant containing the active constituent 7-(4ethyl-l-methyloctyl)-8-hydroxyquinoline. Previous
work in the solvent extraction of germanium with
this reagent has shown that germanium is extracted
most efficiently at low pH. When the germanium is
present in sulphuric acid solutions at pH less than
2, the extracted complex is GeL3+HS04-,however at pH
3 to 8, the metal is extracted as GeL2(OH)2 (where HL
= KELEX 100).
In this work, the extraction kinetics and
equilibrium extraction of germanium in the GeKELEX
100 solvent extraction system is examined by
AKUFVE and shaking assemblies, which both employ
rapid mixing of the organic and aqueous phases, and
by a quiescent interface Lewis Cell.
The AKUFVE is a Swedish designed apparatus for
solvent extraction, its performance and suitability
for solvent extraction studies is evaluated using
the extraction experiments carried out on the GeKELEX
100 solvent extraction system.
Experiments conducted using an experimental set-up
with a large interfacial area to phase volume ratio
reveal that the extraction of germanium occurs in
two distinct kinetic regimes. The first regime
occurs in the first few minutes of an extraction
experiment and is fast relative to the second
kinetic regime which follows this fast initial
extraction period and occurs until the extraction of
germanium attains the equilibrium value. In this
work an extraction mechanism involving interfacial
reaction of germanium and extractant is proposed to
explain this kinetic behaviour.
An increase in ionic strength is shown to reduce the
rate of germanium extraction in the Ge-KELEX 100
solvent extraction system. Modifiers, such as
organic alcohols, are shown to greatly improve
extraction kinetics.Thesis (M.Sc.)-University of Natal, Durban, 1990.
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Chiang, Tsung-Hsien, and 江宗憲. "A new gadolinium(III) complex with 8-hydroxyquinoline based ligand as a copper sensor for MRI." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/55142121332765553096.
Full textAbstract:
碩士國立交通大學
生物科技學系
99
Over the past few years, more and more evidence indicated that the metal ion imbalance in the brain will give rise to many diseases. Magnetic resonance imaging (MRI) is a non-invasive and high resolution technique that has become a powerful diagnostic tool in medicine. In this study, we have developed a new contrast agent [Gd(HQ-DO3A)] that can recognize Cu2+ ion in the cells. The significant increases in the relaxivity (r1) and hydration number (q) in the present of Cu2+ were observed. Moreover, the Gd3+ complex attributes excellent selectivity for Cu2+ over a choice of other metal ions. A gradual increase was shown in the signal enhancement of MR imaging upon copper ion detection. On the other hand, we observed fluorescence intensity decreased via transferring the inner system energy from qunoline ring to Eu3+ when copper was absent. These results implicate that a new MR based contrast agent can serve as a Cu2+ sensor using MR imaging.
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Sigouin, Olivier. "Vers le développement de matériaux à transition de spin : synthèse de différents complexes mono-oxo de rhénium (V) et étude de leur écart HOMO-LUMO." Thèse, 2004. http://hdl.handle.net/1866/16743.
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Chen, Jin-Ying, and 陳瑾瑩. "Determination of Trace Metals in Estuarine Water by 8-Hydroxyquinoline Solid-Phase Extraction and Graphite Atomic Absorption Spectrometry." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/22135394630212496223.
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Chen, Chin-Yin, and 陳瑾瑩. "Determination of Trace Metals in Estuarine Water by 8-Hydroxyquinoline Solid-Phase Extraction and Graphite Atomic Absorption Spectrometry." Thesis, 1998. http://ndltd.ncl.edu.tw/handle/06797169500376425244.
Full textAbstract:
碩士中國文化大學
應用化學研究所
86
Abstract In this study, 8-Hydroxyquinoline (8-HQ) strategy was utilized to extract heavy metals in estuarine water . The concentrated sample was then further analyzed for Cu, Cd by Graphite atomic absorption spectrometry (GAAS). After characterized the synthesized 8-HQ, it found that 8-HQ chelating agent possesses high stability against the fluctuation of the pH value and it will not lose its chelating ability while it was exposed to the testing environment. The optimized working condition of 8-HQ for extraction hey metals in estuarine water was determined by factors including the flowing rate of water sample through 8-HQ as well as the different ratio of HNO3 and HCl contracted acid. When all these factors were determined and then combined, the right procedure for analyzing trace metals in estuarine water was found. Calibrating GAAS experiment in the Zeeman back-ground, finding the correct temperature program for detecting the amount of heavy metals could be simply achieved by changing the temperatures of the four steps of the heating processes(drying, ashing, atomization, cleaning, respectively). Furthermore, adding modifier such as Mg(NO3)2 or Pd-Mg could increase the temperature of ashing step leading to the elimination of any undesired materials in the sample. With these modified steps, all metals could be detectedhile their atomization process takes place. The analyzing method combined GAAS and 8-HQ is not only on the study of trace metals in estuarine water but also on the determination in sea water. So the method provide great potential in coastal estuarine water pollution prevention especially in detecting the existence of heavy metals which is harmful to human.
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Yu-Fang, Jhang, and 張玉芳. "The Photophysical and Photochemical Properties of 2-Styrylquinoline Derivatives：(a) 5-Member Hetero-ring series (b) 8-Hydroxyquinoline series." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/4jws85.
Full textAbstract:
碩士國立嘉義大學
應用化學系研究所
96
Different 2-styrylquinoline derivatives possessing intramolecular charge transfer characters, including 5-member heterocyclic or 8-hydroxyquinoline, were synthesized to study the influence of substituent on the photophysics and photochemistry. For 5-member heterocyclic derivatives, the basicity of the quinoline ring are enhanced in excited state (pKa ⊿= 8 ~ 10). Comparing with thiophene derivatives, pyrrole ring possesses a stronger electron-donating ability. However, these molecules all practiced an excited state proton transfer (ESPT) reaction in strong hydrogen donor solvents, such as the mixed solvents (dichloromethane and trifluoroethanol). The electronic effect of the hydroxyl group depends on the substituent effect for the 8-hydroxyquinoline derivatives. When a strong electron-donating group, such as –NMe2, appeared as a donor part on the 8-hydroxyquinoline derivatives, the hydroxyl group behaves an electron-withdrawing group. However, the hydroxyl group becomes as an electron-donating group when –NMe2 was replaced by –NO2 or protonated –NMe2. The discovery of the electronic-effects inversion for the hydroxyl group on the 8-hydroxyquinoline derivatives is important in studying the mechanism of the ESPT.
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Palardy, Marc. "Complexes mono-oxo de rhénium(V) avec des ligands dérivés de la quinoline et de la cystéine." Thèse, 2007. http://hdl.handle.net/1866/17990.
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Saleem, Ayaan, Paulina A. Kobielska, K. Harms, Maria G. Katsikogianni, Richard Telford, G. Novitchi, and Sanjit Nayak. "Transition metal complexes of a versatile polyalkoxy oxazolidine-based ligand derived from in situ cyclization." 2018. http://hdl.handle.net/10454/15760.
Full textAbstract:
YesOne-pot reaction between 8-hydroxyquinoline-2-carboxaldehyde (HQC) and tris(hydroxymethyl)aminomethane (TRIS) followed by in situ cyclization yielded an oxazolidine based ligand which produced four mononuclear complexes of MnII(1), CoII(2), NiII(3), ZnII(4), a tetranuclear iron (FeIII4) complex (5) and a trinuclear cobalt (CoIICoIII2) complex (6). Magnetic studies show dominant antiferromagnetic interaction in tetranuclear iron (FeIII4) complex 5 and presence of the slow relaxation of magnetisation in 6. The compounds were also studied for their antibacterial properties. The oxazolidine ligand (H3L2) of this study showed good antimicrobial activity not only against Gram-positive bacteria but against Gram-negative bacteria too. The antimicrobial efficacy of the metal complexes (1–6) is also reported.
The full-text of this article will be released for public view at the end of the publisher's embargo period on 11 Apr 2019.
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Varlan, MARIA. "SELECTIVE ACTIVATION OF TERBIUM(III) AND EUROPIUM(III) LUMINESCENCEWITH TRIARYLBORON-FUNCTIONNALIZED CARBOXYLATE LIGANDS. AND LUMINESCENT 8-HYDROXYQUINOLINE DIPICOLYLAMINE COMPLEXES AS SENSORS FOR ZINC(II)." Thesis, 2012. http://hdl.handle.net/1974/7457.
Full textAbstract:
The impact of a tri-substituted boron moiety on the chelate sensitization of Tb(III) and Eu(III) lanthanide luminescence and their resulting photophysical properties was investigated. Two triarylboron-functionalized carboxylate ligands 1 and 2 and their respective Tb(III) and Eu(III) complexes, 1Tb, 2Tb, 1Eu and 2Eu were synthesized and fully characterized. The photophysical properties of these compounds were studied and it was established that these three-coordinate boron ligands are highly effective in selective activation of Tb(III) and Eu(III) luminescence yielding high efficiency green and red luminescence, respectively. Potential applications of these triarylboron-functionalized chelate Tb(III) and Eu(III) complexes as luminescent sensors for dipicolinic acid (DPA), a biomarker for anthrax spores, as well as small anions such as F- and CN- in organic solution were examined by titration experiments using UV-Vis absorption and fluorescence emission measurements. Further studies were carried out into the application of the lanthanide complexes as solid substrate luminescent sensors for the same analytes.
Furthermore a novel zinc-binding compound, composed of both an 8-hydroxyquinoline fluorophore and a dipyridyl metal binding site, was designed for application as a luminescent sensor for Zn(II), due to the recent link between the metal ion and certain high-profile neurological conditions such as Alzheimer’s and epilepsy. The target ligand compound 1-OH was successfully synthesized and characterized using UV-Vis, Fluorescence and NMR spectroscopy. Further studies of the ligand are recorded by studying the effects of the addition of both four-coordinate boron and tris(8-hydroxyquinolinato)aluminum active sites to the 1-OH molecule frame. The four compounds’ abilities in luminescent Zn(II) detection in organic media were examined by titration experiments with Zn(II) using UV-Vis absorption and fluorescence emission measurements.Thesis (Master, Chemistry) -- Queen's University, 2012-09-11 16:36:17.004
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Tong, Shi-Ran, and 童世然. "一. The synthesis and photoluminescence of tris-(7-substituted-8-hydroxyquinoline) aluminum complex and it，s boron complex 二.Application of organic solderability preservatives on printed circuit board." Thesis, 2004. http://ndltd.ncl.edu.tw/handle/85764685305136080566.
Full textAbstract:
碩士國立臺北科技大學
化學工程系碩士班
92
一. In this study, 8-Hydroxyquinoline and allyl bromide synthesize 7-allyl-8-hydroxyquinoline monomers, which were based and heated into 7-（2-methylvinyl）-8-hydroxyquinoline monomers. The monomers of 7-allyl-8-hydroxyquinoline and 7-（2-methyl -vinyl）-8-hydroxyquinoline were formed polymers with the allyl group of structure,respectively. The monomers of 7-allyl-8-hydroxyquinoline and 7-（2-methylvinyl）-8-hydroxyquinoline as well as the polymers of 7-allyl-8-hydroxyquinoline-alt-styrene and 7-（2-methylvinyl）-8-hydroxyquinoline-alt-styrene were formed the complexes individually by the metals of AlCl3 and NaBH4 which investigated into radiation wavelength with the condition of the same and different metals. The results showed that it is more stable since the complex was conjugated into resonance and bring to red shift 二. The O-Phenylenediamine and the carboxylic acid were synthesized the side chain R-group of benzimidazole which formed anti-oxidation layer with copper on surface of Printed Circuit Board in this case. This anti-oxidation layer have easily cleaned by flux to avoid the difficult on PCB process. The results demonstrate that it is formed the optimal membrane thickness when the side chain R-group is C5-C9. The side chain of R-group was increased so that stereo-hindrance increased and the decomposed temperature decreased. The processes make use high temperature weld so as to enhance the decomposed temperature by adding Zn ion.