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Journal articles on the topic '813/.54 b'

Author: Grafiati

Published: 25 July 2024

Last updated: 31 July 2025

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1

WILLIAMS, NICOLE C., and STEVEN C. INGHAM. "Thermotolerance of Escherichia coli O157:H7 ATCC 43894, Escherichia coli B, and an rpoS-Deficient Mutant of Escherichia coliO157:H7 ATCC 43895 Following Exposure to 1.5% Acetic Acid." Journal of Food Protection 61, no. 9 (1998): 1184–86. http://dx.doi.org/10.4315/0362-028x-61.9.1184.

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On a beef carcass, Escherichia coli may sequentially encounter acid- and heat-intervention steps. This study tested whether acid stress (1.5% [vol/vol] acetic acid, pH 4.0, 37°C, 15 min) would enhance subsequent heat resistance of E. coli. Initially, cells (E. coli O157:H7 ATCC 43894, nonpathogenic E. coli B [strain FRIK-124], and rpoS-deficient mutant 813-6 [derived from E. coli O157:H7 ATCC 43895]) were acid stressed and transferred to 54°C tiypticase soy broth (TSB), and survivors were immediately enumerated after at least three intervals of 12, 2, and 6 min, respectively, by plating. The A

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Aggarwal, A., R. Gupta, R. Chatterjee, et al. "POS0773 AUTOANTIBODIES IN A MULTI-INSTITUTIONAL INDIAN COHORT (INSPIRE) OF SLE PATIENTS: PREVALENCE, CLUSTER ANALYSIS AND PHENOTYPE ASSOCIATION." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 673. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4173.

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BackgroundSystemic Lupus Erythematosus (SLE) is characterized by an array of autoantibodies. Different autoantibodies have been associated with different clinical features like anti-dsDNA antibodies with nephritis and anti-phospholipid antibodies with pregnancy loss. However, the prevalence of autoantibodies has been variable across different ethnic groups. Data on the Indian population is limited.ObjectivesTo assess the prevalence of different autoantibodies in a multi-institutional cohort (INSPIRE) of Indian SLE patients and to test their association with various clinical features using clus

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Gutiérrez Castro, Bleenis, José Luis Fernández, Federico Cassella, Andrés Wonaga, and Luis Viola. "Adenoma Detection Rate at Different Age Intervals Suggests Starting Colorectal Cancer Screening at 45 Years of Age." Acta Gastroenterológica Latinoamericana 53, no. 1 (2023): 59–67. http://dx.doi.org/10.52787/agl.v53i1.292.

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Introduction. It is uncertain whether starting screening at 45 years old would improve colorectal cancer prevention and currently available studies in adults younger than 50 years old are limited. Aim. To evaluate the adenoma detection rate at different age intervals. Materials and methods. Colonoscopies performed on adult outpatients were analyzed. Adenoma detection was recorded in the total population and in patients with screening indication. First, patients were divided into two groups: 50 years or older (group A) and younger than 50 years (group B). Then, we analyzed the different age seg

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Venkatesh, V. C., B. C. Planer, M. Schwartz, J. N. Vanderbilt, R. T. White, and P. L. Ballard. "Characterization of the promoter of human pulmonary surfactant protein B gene." American Journal of Physiology-Lung Cellular and Molecular Physiology 268, no. 4 (1995): L674—L682. http://dx.doi.org/10.1152/ajplung.1995.268.4.l674.

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Pulmonary surfactant protein B (SP-B) is required for normal surfactant function and for survival at birth. To further study SP-B gene expression, we sequenced genomic clones and examined promoter activity of SP-B DNA fragments by transient transfection. A plasmid construct containing human SP-B fragment -1039/+431 linked to chloramphenicol acetyltransferase (CAT) reporter gene was readily expressed in H441 cells, which are derived from a human lung adenocarcinoma, but was < 4% as active in Hep G2, HeLa, and Calu 6 cell lines. SP-B promoter activity in H441 cells was orientation dependent a

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Guo, Yi-Qing, Zhen Tian, and Chao Jin. "SPATIAL-DEPENDENT PROPAGATION OF COSMIC RAYS RESULTS IN SPECTRUM OF PROTON, RATIOS OF $\bar{p}/p$, B/C AND ANISOTROPY OF NUCLEI." Astrophysical Journal 819, no. 1 (2016): 54. http://dx.doi.org/10.3847/0004-637x/819/1/54.

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Chu, Charles C., Stephanie T. Reese, Leslie O. Goodwin, et al. "Is Elevated Serum IL-10 in B-CLL Associated with IL-10 Promoter Polymorphisms?." Blood 106, no. 11 (2005): 1198. http://dx.doi.org/10.1182/blood.v106.11.1198.1198.

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Abstract Interleukin-10 (IL-10), a cytokine that regulates inflammation, may play an important role in B-cell chronic lymphocytic leukemia (B-CLL), because of the reported association of high serum IL-10 levels with a lower prognosis of survival. Using the Bio-Plex protein array system, we confirmed that B-CLL patients exhibit higher median IL-10 levels (3.54 pg/ml, n=50) as compared to controls (1.28 pg/ml, n=33) (p&lt;0.0001). We are in the midst of determining B-CLL VH gene mutation status and IL-10 levels. To determine if elevated IL-10 levels are due to inherent genetic polymorphisms,

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Rocha, Sónia, Sandra Tejo, Eugénia Ferreira, et al. "Seroprevalência do Anticorpo do Vírus na Hepatite A em Viajantes Portugueses: Um Novo Paradigma." Acta Médica Portuguesa 30, no. 7-8 (2017): 534. http://dx.doi.org/10.20344/amp.8130.

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Introduction: In Portugal, the prevalence of hepatitis A virus infection has decreased in the past decades, especially in young adults. The aim of this study was to detect the prevalence of antibody to hepatitis A virus in a population observed in our Travel Clinic.Material and Methods: Antibodies against hepatitis A, hepatitis B, hepatitis C and human immunodeficiency virus were tested using standard enzyme immunoassay in patients older than 18. The exclusion criteria were: prior vaccination for hepatitis A virus, previous diagnosis of infection with hepatitis B virus, hepatitis C virus and/o

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D’Auria, Fiorella, Luciana Valvano, Luciana Rago, et al. "Monoclonal B-cell lymphocytosis and prostate cancer: incidence and effects of radiotherapy." Journal of Investigative Medicine 67, no. 4 (2019): 779–82. http://dx.doi.org/10.1136/jim-2018-000902.

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Monoclonal B-cells lymphocytosis (MBL) is a benign condition that may precede chronic lymphocytic leukemia (CLL), not rarely present in peripheral blood of healthy elderly people, among which there is also a male prevalence. Though CLL has been associated with various types of solid tumors, including prostate cancer (PC), no data exist about the relationship between PC and MBL. We studied the frequency of CLL-like MBL clones in a group of 48 patients affected by PC and followed them during and after whole-pelvis radiotherapy (WPRT) treatment. We found four MBL clones (8.3%), two of which (4.2%

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Hajsadeghi, Shokoufeh, Niloufar Samiei, Masoud Moradi, et al. "Comparison of N-Terminal Pro B-Natriuretic Peptide and Echocardiographic Indices in Patients with Mitral Regurgitation." Clinical Medicine Insights: Cardiology 4 (January 2010): CMC.S6062. http://dx.doi.org/10.4137/cmc.s6062.

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Introduction Echocardiographic indices can form the basis of the diagnosis of systolic and diastolic left ventricular (LV) dysfunction in patients with Mitral regurgitation (MR). However, using echocardiography alone may bring us to a diagnostic dead-end. The aim of this study was to compare N-Terminal pro B-natriuretic peptide (BNP) and echocardiographic indices in patients with mitral regurgitation. Methods 2D and Doppler echocardiography and BNP serum level were obtained from 54 patients with organic mild, moderate and severe MR. Results BNP levels were increased with symptoms in patients w

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Lopes, S. R. M., N. W. S. Gormezano, R. C. Gomes, et al. "Outcomes of 847 childhood-onset systemic lupus erythematosus patients in three age groups." Lupus 26, no. 9 (2017): 996–1001. http://dx.doi.org/10.1177/0961203317690616.

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Objective The objective of this study was to assess outcomes of childhood systemic lupus erythematosus (cSLE) in three different age groups evaluated at last visit: group A early-onset disease (<6 years), group B school age (≥6 and <12 years) and group C adolescent (≥12 and <18 years). Methods An observational cohort study was performed in ten pediatric rheumatology centers, including 847 cSLE patients. Results Group A had 39 (4%), B 395 (47%) and C 413 (49%). Median disease duration was significantly higher in group A compared to groups B and C (8.3 (0.1–23.4) vs 6.2 (0–17) vs 3.3 (0

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Koondhar, Noor Nabi, Arfan Ahmed Gilal, Lubna Bashir Rajput, et al. "Varietal Preference of Black Bug Cavelerius excavatus Distant (Hemiptera: Lygaeidae) on Sugarcane in Field." Journal of Agriculture and Veterinary Science 3, no. 3 (2024): 479–86. https://doi.org/10.55627/agrivet.003.03.0910.

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Black bug, Cavelerius excavatus is a serious pest of sugarcane that causes huge losses under favorable conditions. Considering its recent losses in Sindh, Pakistan, this experiment was carried out at Sugarcane Research Institute, Agriculture Research Center, Tandojam to determine their population preference of Cavelerius excavatus on nineteen sugarcane varieties. The sugarcane varieties used in the study were NSG-45, B-46-364, BO 14, B-6705, B-6518, CO-419, CP-68-1059, CO-474, CO-616, CO-557, CO-235, B-54-142, CO-475, CO-620, LRK-2001, Raja-14, Q-88, PSTj-41 and LAmTj-76/803. The experiment wa

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Tumanov, Nikolay A., and Elena V. Boldyreva. "X-ray diffraction and Raman study of DL-alanine at high pressure: revision of phase transitions." Acta Crystallographica Section B Structural Science 68, no. 4 (2012): 412–23. http://dx.doi.org/10.1107/s0108768112028972.

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The effect of pressure on DL-alanine has been studied by X-ray powder diffraction (up to 8.3 GPa), single-crystal X-ray diffraction and Raman spectroscopy (up to ∼ 6 GPa). No structural phase transitions have been observed. At ∼ 1.5–2 GPa, cell parameters b and c become accidentally equal to each other, but the space-group symmetry does not change. There is no phase transition between 1.7 and 2.3 GPa, contrary to what has been reported earlier [Belo et al. (2010). Vibr. Spectrosc. 54, 107–111]. The presence of the second phase transition, which was claimed to appear within the pressure range f

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Zhang, L., D. J. Jacob, K. F. Boersma, et al. "Transpacific transport of ozone pollution and the effect of recent Asian emission increases on air quality in North America: an integrated analysis using satellite, aircraft, ozonesonde, and surface observations." Atmospheric Chemistry and Physics Discussions 8, no. 2 (2008): 8143–91. http://dx.doi.org/10.5194/acpd-8-8143-2008.

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Abstract. We use an ensemble of aircraft, satellite, sonde, and surface observations for April–May 2006 (NASA/INTEX-B aircraft campaign) to better understand the mechanisms for transpacific ozone pollution and its implications for North American air quality. The observations are interpreted with a global 3-D chemical transport model (GEOS-Chem). OMI NO2 satellite observations constrain Asian anthropogenic NOx emissions and indicate a factor of 2 increase from 2000 to 2006 in China. Satellite observations of CO from AIRS and TES indicate two major events of Asian transpacific pollution during I

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HARIRAM, UPASANA, and RONALD LABBÉ. "Spore Prevalence and Toxigenicity of Bacillus cereus and Bacillus thuringiensis Isolates from U.S. Retail Spices." Journal of Food Protection 78, no. 3 (2015): 590–96. http://dx.doi.org/10.4315/0362-028x.jfp-14-380.

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Recent incidents of foodborne illness associated with spices as the vehicle of transmission prompted this examination of U.S. retail spices with regard to Bacillus cereus. This study focused on the levels of aerobic-mesophilic spore-forming bacteria and B cereus spores associated with 247 retail spices purchased from five states in the United States. Samples contained a wide range of aerobic-mesophilic bacterial spore counts (&lt; 200 to 8.3 × 107 CFU/g), with 19.1% of samples at levels above 105 CFU/g. For examples, paprika, allspice, peppercorns, and mixed spices had high levels of aerob

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Kobayashi, Hiroki, Yoshihiro Nakamura, Masanori Abe, et al. "Effect of cosyntropin during adrenal venous sampling on subtype of primary aldosteronism: analysis of surgical outcome." European Journal of Endocrinology 182, no. 3 (2020): 265–73. http://dx.doi.org/10.1530/eje-19-0860.

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Objectives We investigated the clinical significance of ACTH stimulation during adrenal venous sampling (AVS) by surgical outcome of primary aldosteronism (PA). Design Multicenter retrospective study by Japan PA study. Method We allocated 314 patients with both basal and ACTH-stimulated AVS data who underwent adrenalectomy to three groups: basal lateralization index (LI) ≥2 with ACTH-stimulated LI ≥4 on the ipsilateral side (Unilateral (U) to U group, n = 245); basal LI <2 with ACTH-stimulated LI ≥4 (Bilateral (B) to U group, n = 15); and basal LI ≥2 with ACTH-stimulated LI <4 (U to B gr

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Reinson, Tina, Christopher D. Byrne, Janisha Patel, Magdy El-Gohary, and Michael Moore. "Transient elastography in patients at risk of liver fibrosis in primary care: a follow-up study over 54 months." BJGP Open 5, no. 6 (2021): BJGPO.2021.0145. http://dx.doi.org/10.3399/bjgpo.2021.0145.

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BackgroundLiver fibrosis assessment services using transient elastography are growing in primary care. These services identify patients requiring specialist referral for liver fibrosis, and provide an opportunity for recommending lifestyle change. However, there are uncertainties regarding service design, effectiveness of advice given, and frequency of follow-up.AimTo assess the following: (a) effectiveness of standard care lifestyle advice for weight management and alcohol consumption; (b) uptake for liver rescan; and (c) usefulness of a 4.5-year time interval of rescanning in monitoring prog

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Biganzoli, L., H. Cortes-Funes, C. Thomssen, et al. "Tolerability and efficacy of first-line bevacizumab (B) plus chemotherapy (CT) in elderly patients with advanced breast cancer (aBC): Subpopulation analysis of the MO19391 study." Journal of Clinical Oncology 27, no. 15_suppl (2009): 1032. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.1032.

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1032 Background: Limited data exist on the efficacy and safety of biological agents in elderly patients with aBC. This is essentially due to the lack of studies specifically targeting the older population and to strict inclusion criteria in clinical trials. B significantly improved the efficacy of 1st-line taxane therapy in two large, randomized phase III trials, E2100 and AVADO. Methods: In study MO19391, 1st-line B 10mg/kg q2w or 15mg/kg q3w + CT (primarily but not exclusively taxane monotherapy) was investigated in a broader, large aBC patient population, with the aim of understanding safet

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Nazir, Mashal, Rahman Ullah, Aqsa Saleema, et al. "Compare Short Term Post-Operative Complication of Laparoscopic Transabdominal Preperitoneal (TAPP) and Lichtenstein’s Tension Free Hernia Repair." Pakistan Journal of Medical and Health Sciences 16, no. 8 (2022): 859–61. http://dx.doi.org/10.53350/pjmhs22168859.

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Objective: To compare short term post-operative complication of laparoscopic transabdominal preperitoneal (TAPP) and Lichtenstein’s tension free hernia repair. Study Design: Randomized clinical trial. Place & Duration of Study: Surgical Unit of Khyber Teaching Hospital (KTH) Peshawar during the period of 6 months from 1st January, 2020 to 30 June, 2021. Material and Methods: In this study 492 cases of inguinal Hernia with 246 in each group. For group A, laparoscopic TAPP repair were performed with 10cmx 15cm polyprophlene mesh (prolene-Ethicon) and were fixed with tackers (Protack 5mm fixa

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Harnett, P., M. Buck, P. Beale, et al. "Phase II study of gemcitabine and oxaliplatin in patients with recurrent ovarian cancer: an Australian and New Zealand Gynaecological Oncology Group study." International Journal of Gynecologic Cancer 17, no. 2 (2007): 359–66. http://dx.doi.org/10.1111/j.1525-1438.2007.00763.x.

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Gemcitabine and oxaliplatin have shown single-agent activity in relapsed ovarian cancer. This combination was used to determine response rates, time-to-event efficacy measures, and toxicity in patients with recurrent ovarian cancer. Patients with prior platinum-based chemotherapy who had measurable lesions and/or elevated CA-125 levels were identified as group A (platinum-refractory/platinum-resistant patients) and group B (platinum-sensitive patients). All patients received gemcitabine 1000 mg/m2 on days 1 and 8 and oxaliplatin 130 mg/m2 on day 8 every 21 days for up to eight cycles. Seventy-

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Vose, J., P. Bierman, G. Bociek, et al. "Radioimmunotherapy with 131-I tositumomab enhanced survival in good prognosis relapsed and high-risk diffuse large B-cell lymphoma (DLBCL) patients receiving high-dose chemotherapy and autologous stem cell transplantation." Journal of Clinical Oncology 25, no. 18_suppl (2007): 8013. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.8013.

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8013 Background: The 5-year overall survival (OS) for pts with relapsed chemosensitive DLBCL with standard transplantation is approximately 40–50%. We previously piloted the addition of standard outpatient radioimmunotherapy (RIT) with 131-I tositumomab to the transplant regimen for patients with relapsed chemoresistant NHL. This phase I study demonstrated a 3 yr OS of 55% in these poor prognosis patients (JCO 23: 461–467, 2005). The current study is a follow-up phase II study in good prognosis relapsed and high risk DLBCL patients using 131-I tositumomab with BEAM (BCNU, etoposide, cytarabine

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Intragumtornchai, Tanin, Udomsak Bunworasate, Thanyaphong Na Nakorn, and Ponlapat Rojnuckarin. "Alemtuzumab in Combination with CHOP and ESHAP as First-Line Treatment in Peripheral T-Cell Lymphoma." Blood 108, no. 11 (2006): 4740. http://dx.doi.org/10.1182/blood.v108.11.4740.4740.

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Abstract Patients diagnosed with peripheral T-cell lymphomas (PTCL) generally had a poorer prognosis compared to B-cell non-Hodgkin’s lymphomas. With conventional treatment, the 5-year overall and failure-free survivals (OS and FFS) were 36% and 23%, respectively (Vose et al, Blood2005;106:abstract 811). Between February 2005 and January 2006, 13 consecutive patients newly diagnosed with PTCL (5, extranodal nasal NK/T-cell lymphoma, 4 subcutaneous panniculitis-like, 3 PTCL, unspecified and 1 enteropathy type) were enrolled. The median age was 44 years (range, 21–56) and male:female was 1.6:1.

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Zhou, Caicun, Yi-Long Wu, Gongyan Chen, et al. "BEYOND: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Phase III Study of First-Line Carboplatin/Paclitaxel Plus Bevacizumab or Placebo in Chinese Patients With Advanced or Recurrent Nonsquamous Non–Small-Cell Lung Cancer." Journal of Clinical Oncology 33, no. 19 (2015): 2197–204. http://dx.doi.org/10.1200/jco.2014.59.4424.

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Purpose The phase III BEYOND trial was undertaken to confirm in a Chinese patient population the efficacy seen with first-line bevacizumab plus platinum doublet chemotherapy in globally conducted studies. Patients and Methods Patients age ≥ 18 years with locally advanced, metastatic, or recurrent advanced nonsquamous non–small-cell lung cancer (NSCLC) were randomly assigned to receive carboplatin (area under the curve, 6) intravenously and paclitaxel (175 mg/m2) intravenously (CP) on day 1 of each 3-week cycle, for ≤ six cycles, plus placebo (Pl+CP) or bevacizumab (B+CP) 15 mg/kg intravenously

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Kambhampati, Swetha, Kelly Bauer, Jimmy Hwang, Andrea Grace Bocobo, John Dozier Gordan, and Robin Kate Kelley. "Nivolumab in advanced hepatocellular carcinoma (HCC) and Child Pugh B (CPB) cirrhosis: Safety and clinical outcomes in a retrospective case series." Journal of Clinical Oncology 36, no. 4_suppl (2018): 496. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.496.

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496 Background: HCC patients (pts) with Child Pugh B (CPB) cirrhosis have poor prognosis and limited treatment (Tx) options. Nivolumab demonstrated durable responses and acceptable safety in Child Pugh A (CPA) HCC in the CheckMate-040 trial with rates of hepatotoxicity similar to non-HCC populations. The safety and efficacy of nivolumab has not been established in pts with CPB cirrhosis. Methods: Design: Retrospective case series with IRB approval. Key eligibility: HCC with CPB cirrhosis; treated with nivolumab as standard Tx; enrolled in the UCSF Hepatobiliary Tissue Bank and Registry. Study

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., Ibrahim, Farhana Ahmad, Anila Farhat, Nayab Butt, Muhammad Attique Sadiq, and Abid Rafiq Chaudhry Md. "Ondansetron vs Domperidone in the Treatment of Vomiting in Children with Acute Diarrhea: A Randomized, Double-Blind Study." Pakistan Journal of Medical and Health Sciences 16, no. 1 (2022): 944–47. http://dx.doi.org/10.53350/pjmhs22161944.

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Objective: The aim of this study is to compare the efficacy of oral ondansetron with oral domperidone in reducing vomiting in children with acute diarrhea. Study Design: Randomized control trial Place and Duration:The study was conducted atChildren Medical Center (CMC) / Dr Habibun Nabi Children Hospital, Airport Road Mingora Swat and Paediatrics department of Central Park Teaching Hospital, Lahore during the period fromJanuary 2020 to September 2020. Methods: Total one hundred and fifty children with ages 1-7 years were presented in this study. Children had diarrhea and vomiting from the last

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Neubauer, Aljoscha, Susanne Guthoff-Hagen, Jacob Menzler, Carsten Schwenke, Markus Rueckert, and Axel Boehnke. "VP46 German Claims Data In Rare Disease HTA: Diffuse Large B-cell Lymphoma." International Journal of Technology Assessment in Health Care 35, S1 (2019): 87. http://dx.doi.org/10.1017/s0266462319003143.

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IntroductionIn rare disease areas representative data are scarce. Routine sick fund claims data provide a meaningful and reliable base for the in- and outpatient treatment landscape. This real-world data (RWE) from Germany was used to describe treatment patterns for Diffuse Large B-cell Lymphoma (DLBCL), the most frequent and aggressive non-Hodgkin lymphoma type in adults.MethodsClaims data from several sick funds of 4.8 Million insured were analyzed. Diagnosis of non-follicular Lymphoma (C83) was confirmed in 2.178 patients, DLBCL (C83.3) in 819 patients. The analysis was age- and gender-adju

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Murai, Kazunori, Shugo Kowata, Akiko Abo, Tatsuo Oyake, Shigeki Ito, and Yoji Ishida. "Hepatotoxicity During Eltrombopag Administration Might Be Due to Necrosis of Hepatocytes." Blood 118, no. 21 (2011): 2228. http://dx.doi.org/10.1182/blood.v118.21.2228.2228.

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Abstract Abstract 2228 Background: Eltrombopag is an oral thrombopoietin receptor agonist for the treatment of immune thrombocytopenic patients who are refractory to the medications including corticosteroid. In RAISE study (The Lancet 2011: 377; 393–402), 79% patients in the eltrombopag group responded to treatment at least once during the study. However, 7% of eltrombopag-treated patients had increase of alanine aminotransferase (ALT) concentration and 4% of total bilirubin. The mechanism of eltrombopag-induced hepatobiliary toxicity remains unknown. In this study, we evaluated the effects of

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Petrova, Penka, Alexander Arsov, Ivan Ivanov, Lidia Tsigoriyna, and Kaloyan Petrov. "New Exopolysaccharides Produced by Bacillus licheniformis 24 Display Substrate-Dependent Content and Antioxidant Activity." Microorganisms 9, no. 10 (2021): 2127. http://dx.doi.org/10.3390/microorganisms9102127.

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Bacillus licheniformis is a soil bacterium with many industrial applications. In addition to enzymes, platform chemicals, antibiotics and phytohormones, the species produces exopolysaccharides (EPSs) of various biological activities. This study revealed that Bulgarian isolate B. licheniformis 24 produced EPSs consisting of galactose, glucose and mannose with substrate-dependent ratio. From glucose, B. licheniformis 24 secreted EPS1, consisting of 54% galactose, 39% glucose and 7% mannose. From fructose, the strain formed EPS2, containing 51% glucose, 30% mannose and 19% galactose. Batch cultiv

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Minoda, S., R. Sada, S. Matsushita, et al. "POS0516 REDEFINING THE CLINICAL AND LABORATORY FEATURES OF RHEUMATIC PLEURAL EFFUSION: A 30-CASE SERIES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 492.1–492. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1197.

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Background:Rheumatoid pleural effusion (RPE) is a common extra-articular complication in patients with rheumatoid arthritis (RA). Previous studies have shown that RPE usually occurs in middle-aged men with rheumatoid factor (RF)-positive RA. RPE usually has features of pleural fluid acidosis, high lactate dehydrogenase (LDH) levels, and very low glucose levels(1). However, to the best of our knowledge, these findings were based on very few case series and reports, and most of these reports were published by the early 2000s(1, 2).Objectives:To investigate the clinical and laboratory characteris

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El Saghir, Nagi S., Seock-Ah Im, Hamdy A. Azim, et al. "First-line (1L) ribociclib (RIB) + endocrine therapy (ET) vs combination chemotherapy (combo CT) in clinically aggressive hormone receptor (HR)+/HER2− advanced breast cancer (ABC): A subgroup analysis of patients (pts) with or without liver metastases (mets) from RIGHT Choice." Journal of Clinical Oncology 43, no. 16_suppl (2025): 1069. https://doi.org/10.1200/jco.2025.43.16_suppl.1069.

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1069 Background: The phase II RIGHT Choice trial reported a statistically significant progression-free survival (PFS) benefit at the primary prespecified analysis and a 9-month (mo) benefit at the final analysis with 1L RIB + ET over combo CT in pts with clinically aggressive HR+/HER2– ABC. As liver mets in ABC indicate a worse prognosis, an analysis by liver mets status was performed (data cutoff: May 10 th , 2023). Methods: Pre- and perimenopausal women (N = 222) with no prior systemic therapy for clinically aggressive HR+/HER2− ABC were randomized 1:1 to receive RIB + letrozole or anastrozo

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Fazzio, Luis E., Nicolas Yacachury, Walter R. Galvan, Elias Peruzzo, Ricardo O. Sánchez, and Eduardo J. Gimeno. "Impact of ivermectin-resistant gastrointestinal nematodes in feedlot cattle in Argentina." Pesquisa Veterinária Brasileira 32, no. 5 (2012): 419–23. http://dx.doi.org/10.1590/s0100-736x2012000500010.

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The aim was to evaluate for 75 days the impact on production of the remaining burden of ivermectin (IVM)-resistant parasites in naturally infected feedlot calves. The herds came from tick-infested areas of cattle breeding where the systematic use of IVM to control tick increases the gastrointestinal parasites resistant to this drug. This investigation was carried out in two commercial feedlots in Buenos Aires province. In feedlot A, two groups of 35 animal each received IVM 1% and the other received ricobendazole (RBZ) 10% respectively. The same was done in feedlot B. On day 0, two groups of 3

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Thu, Le Thi Arm, Michael J. Dibley, Vo Van Nho, Lennox Archibald, William R. Jarvis, and Annette H. Sohn. "Reduction in Surgical Site Infections in Neurosurgical Patients Associated With a Bedside Hand Hygiene Program in Vietnam." Infection Control & Hospital Epidemiology 28, no. 05 (2007): 583–88. http://dx.doi.org/10.1086/516661.

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Objective. We conducted an intervention study to assess the impact of the use of an alcohol-chlorhexidine-based hand sanitizer on surgical site infection (SSI) rates among neurosurgical patients in Ho Chi Minh City, Vietnam. Design. A quasi-experimental study with an untreated control group and assessment of neurosurgical patients admitted to 2 neurosurgical wards at Cho Ray Hospital between July 11 and August 15, 2000 (before the intervention), and July 14 and August 18, 2001 (after the intervention). A hand sanitizer with 70% isopropyl alcohol and 0.5% Chlorhexidine gluconate was introduced,

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Daly, Hafedh. "Diagnosis and Management of Acute Limb Ischemia." Angiology & Vascular Surgery 7, no. 2 (2022): 1–6. http://dx.doi.org/10.24966/avs-7397/100089.

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Introduction: Acute limb ischemia is considered as a life threatening disease .After twelve hours of ischemia, chances of saving the ischemic limb are lower (78%), with higher mortality (31%) as well. Methods: A total of 54 patients who underwent surgery for acute non traumatic limb ischemia between January 2013 and December 2020 were retrospectively reviewed. Results: We included 30 women and 24 men; median age was 69 years. Twenty patients (37%) were presented with upper limb ischemia, where as 34 patients (63%) with lower limb ischemia. Mean delay between the onset of symptoms and hospital

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Roick, Julia, Peter Esser, Beate Hornemann, Anja Mehnert, and Jochen Ernst. "Warum gerade ich? – Subjektive Krankheitsursachen und Zusammenhänge zu sozialen Faktoren und wahrgenommener Stigmatisierung bei Brust-, Prostata-, Darm- und Lungenkrebspatienten." PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie 70, no. 01 (2019): 22–31. http://dx.doi.org/10.1055/a-0851-6758.

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Zusammenfassung Hintergrund Subjektive Krankheitsursachen gehen vielfach mit Selbstbeschuldigung und Schamgefühlen einher. Diese psychosozialen Belastungen können durch mögliche Stigmatisierungserfahrungen verstärkt werden. Die vorliegende Studie untersucht Annahmen zu subjektiven Krankheitsursachen von Krebspatienten und prüft Zusammenhänge mit sozialen Faktoren und dem Grad erlebter Stigmatisierung. Methoden Im Rahmen einer bizentrischen Studie wurden 858 Patienten mit Brust-, Darm-, Lungen oder Prostatakrebs quantitativ befragt, von denen 815 in die Berechnungen eingingen. Subjektive Krankh

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Dorofieieva, O. E., K. S. Yarymbash, O. A. Glinyana, Yu V. Syomych, and I. T. Skrypchenko. "Rehabilitation diagnosis of patients with mine-explosive wounds of the lower leg based on the international classification of functioning, disability and health." Medicni perspektivi 28, no. 2 (2023): 143–49. http://dx.doi.org/10.26641/2307-0404.2023.2.283384.

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Mine-explosive wounds at the level of the lower leg are accompanied by significant functional disorders, leading to long-term disability, and in some cases – to disability. The introduction at the state level of the document of the International Classification of Functioning, Disabilities and Health (ICF) in the treatment and rehabilitation process of medical institutions, necessitates its detailed study and application for making a rehabilitation diagnosis of patients. The aim of this study is to improve the process of rehabilitation diagnosis of patients with mine-explosive wounds of the low

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Dorofieieva, O.E., K.S. Yarymbash, O.A. Glinyana, Yu.V. Syomych, and I.T. Skrypchenko. "Rehabilitation diagnosis of patients with mine-explosive wounds of the lower leg based on the international classification of functioning, disability and health." Medicni perspektivi 28, no. 2 (2023): 143–49. https://doi.org/10.26641/2307-0404.2023.2.283384.

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Mine-explosive wounds at the level of the lower leg are accompanied by significant functional disorders, leading to long-term disability, and in some cases – to disability. The introduction at the state level of the document of the International Classification of Functioning, Disabilities and Health (ICF) in the treatment and rehabilitation process of medical institutions, necessitates its detailed study and application for making a rehabilitation diagnosis of patients. The aim of this study is to improve the process of rehabilitation diagnosis of patients with mine-explosive wounds of t

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Grant, Conor, Sarah O'Connell, Darren Lillis, et al. "Opt-out screening for HIV, hepatitis B and hepatitis C: observational study of screening acceptance, yield and treatment outcomes." Emergency Medicine Journal 37, no. 2 (2019): 102–5. http://dx.doi.org/10.1136/emermed-2019-208637.

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BackgroundWe initiated an emergency department (ED) opt-out screening programme for HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) at our hospital in Dublin, Ireland. The objective of this study was to determine screening acceptance, yield and the impact on follow-up care.MethodsFrom July 2015 through June 2018, ED patients who underwent phlebotomy and could consent to testing were tested for HIV, HBV and HCV using an opt-out approach. We examined acceptance of screening, linkage to care, treatment and viral suppression using screening programme data and electronic health records. Th

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Okuno, Scott, William J. Maples, Michelle R. Mahoney, et al. "Evaluation of Epothilone B Analog in Advanced Soft Tissue Sarcoma: A Phase II Study of the Phase II Consortium." Journal of Clinical Oncology 23, no. 13 (2005): 3069–73. http://dx.doi.org/10.1200/jco.2005.00.372.

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Purpose Epothilones are a new class of nontaxane tubulin polymerization agents that have activity in taxane-resistant tumors. Epothilone B (BMS-247550) is a semisynthetic analog of the natural product epothilone B. This study was performed to determine the activity of BMS-247550 in patients with soft tissue sarcomas (STSs) who had not received prior chemotherapy for metastatic disease. Patients and Methods Patients with measurable, advanced, or metastatic STS with no prior chemotherapy for metastatic disease were treated with BMS-2457550 50 mg/m2 intravenously during 1 hour every 21 days. All

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Sartori, Giulio, Filippo Spriano, Luciano Cascione, et al. "Abstract B170: The in vitro anti-tumor activity of the multi-kinase inhibitor nemtabrutinib (ARQ-531, MK-1026) is seen across multiple B-cell lymphoma subtypes, only partially overlapping with what achieved by single BTK inhibition." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B170. http://dx.doi.org/10.1158/1535-7163.targ-23-b170.

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Abstract Background. Nemtabrutinib is a reversible, ATP competitive tyrosine kinase inhibitor of BTK and of several other kinases, including LYN and MEK1 (Reiff et al, Cancer Discov 2018). Nemtabrutinib has shown preclinical and clinical activity in chronic lymphocytic leukemia (CLL), also against tumors bearing mutations affecting the C481 amino acid of BTK (Reiff et al, Cancer Discov 2018; Eradat et al, ICML 2023), which is commonly mutated in patients treated with 1st and 2nd generation inhibitors such as ibrutinib, acalabrutinib, zanubrutinib (Thompson & Tam, Blood 2023). Based on thes

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Kedra, Joanna, Raphaele Seror, Philippe Dieudé, et al. "Lymphoma complicating rheumatoid arthritis: results from a French case–control study." RMD Open 7, no. 3 (2021): e001698. http://dx.doi.org/10.1136/rmdopen-2021-001698.

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Objectives To study the characteristics of B-cell non-Hodgkin’s lymphoma (NHL) or Hodgkin lymphoma complicating rheumatoid arthritis (RA) and to identify RA-related factors associated with their occurrence. Methods A multicentre case–control study was performed in France. Cases were patients with RA fulfilling ACR-EULAR 2010 criteria in whom B-cell NHL or Hodgkin lymphoma developed after the diagnosis of RA. For each case, 2 controls were assigned at random from the ESPOIR cohort and were matched on age at lymphoma diagnosis (cases)/age at the 10-year follow-up visit in the cohort (controls).

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Atwill, E. R., B. Hoar, M. das Graças Cabral Pereira, K. W. Tate, F. Rulofson, and G. Nader. "Improved Quantitative Estimates of Low Environmental Loading and Sporadic Periparturient Shedding of Cryptosporidium parvum in Adult Beef Cattle." Applied and Environmental Microbiology 69, no. 8 (2003): 4604–10. http://dx.doi.org/10.1128/aem.69.8.4604-4610.2003.

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ABSTRACT Our primary goal was to generate an accurate estimate of the daily environmental loading rate of Cryptosporidium parvum oocysts for adult beef cattle, using immunomagnetic separation coupled with direct immunofluorescence microscopy for a highly sensitive diagnostic assay. An additional goal was to measure the prevalence and intensity of fecal shedding of C. parvum oocysts in pre- and postparturient cows as an indicator of their potential to infect young calves. This diagnostic method could detect with a ≥90% probability oocyst concentrations as low as 3.2 oocysts g of feces−1, with a

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Ragg, J. C. "Film compression bandage." Phlebologie 44, no. 05 (2015): 249–55. http://dx.doi.org/10.12687/phleb2276-5-2015.

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SummaryPurpose: Textile compression stockings or bandages are limited in comfort; they do not allow uninterrupted wearing. A novel elastic film bandage was evaluated regarding practicability, patient comfort and effect on vein regression. Main endpoint was the frequency of symptomatic inflammatory reactions.Methods: In a comparative pilot study, a compression film bandage (CFB, investigational) comprising an elastic, self-adhesive breathable polymer film of d <20 µm was continuously worn for 14 d after foam sclero-therapy. Inclusion: 62 patients (26–68 y.) frequently doing sports and taking

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Lee, Sang-Ho, H. Yener Erken, and Junseok Bae. "Percutaneous Transforaminal Endoscopic Lumbar Interbody Fusion: Clinical and Radiological Results of Mean 46-Month Follow-Up." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/3731983.

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Background. Spinal fusion has been shown to be the preferred surgical option to reduce pain, recover function, and increase quality of life in the treatment of a variety of lumbar spinal disorders. The main goal of the present study is to report our clinical experience and results of percutaneous transforaminal endoscopic lumbar interbody fusion (PELIF) applications using the expandable spacer in a single institution.Methods. We performed a retrospective review of 18 patients with >12-month follow-up who had been operated on PELIF using expandable spacer from 2001 to 2007. Their clinical an

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Choi, Gwang-Jun, Ji Young Park, Joon-Sik Choi, et al. "724. Neurologic Complications in Hospitalized Pediatric Patients with Influenza Infection, A Multicenter Retrospective Study in Korea." Open Forum Infectious Diseases 5, suppl_1 (2018): S260. http://dx.doi.org/10.1093/ofid/ofy210.731.

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Abstract Background The aim of the study was to evaluate the incidence and characteristics of influenza associated neurologic complications (IANCs) in hospitalized pediatric patients in Korea. Methods We performed retrospective review of hospitalized cases of confirmed influenza infection from October 2010 to April 2017. Patient’s data were collected from three referral hospitals in different regions of the country. Results A total 2,002 laboratory confirmed influenza cases were identified. The median age was 3.3 years old (range 0.0–18.9 years) and 1,003 patients were male (54%). Influenza A

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Kuzmin, S. A., and L. K. Grigorieva. "Health profiling of conscripts from the Orenburg region drafted to serve in the Armed Forces of Russia." Medicо-Biological and Socio-Psychological Problems of Safety in Emergency Situations, no. 3 (November 12, 2024): 54–65. http://dx.doi.org/10.25016/2541-7487-2024-0-3-54-65.

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Relevance. Amid international unrest, Russia’s top priority is to augment its defense capacities. The President of Russia decided to increase the army and navy corps by 30 %. To fulfill this task, physically strong and healthy conscripts are required to man the military units.The objective is to analyze medical examination data of drafted young men aged 17 to assess the health profile of conscripts from the Orenburg region.Methods. The study relied on Rosstat statistics for the Orenburg region, as well as reports and records of the Military Medical Expertise Center at the Federal Budgetary Ins

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Kim, Jee Hung, Soong June Bae, Sung Gwe Ahn, et al. "Abstract PO5-02-09: Discordance of the PAM50 intrinsic subtypes with the immunohistochemistry-based subtypes in HER2-negative early breast cancer treated with neoadjuvant chemotherapy." Cancer Research 84, no. 9_Supplement (2024): PO5–02–09—PO5–02–09. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-02-09.

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Abstract Background The PAM50 (Prosigna Breast Cancer Gene Signature Assay) can be used to assess the expression levels of 50 genes in early breast cancer biopsies, including formalin-fixed paraffin-embedded (FFPE) tissue from human epidermal growth factor receptor 2 (HER2)-negative patients. However, there is currently no practical molecular assay for intrinsic subtype in real-world practice that addresses the problems of cost and run-time. Methods In the phase 2 HER2E-PAM/PAMILIA study (NCT04817540), we prospectively analyzed molecular subtyping through the PAM50 test in low HER2 (HER2 IHC 1

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Hassan, Neelma, Suleman Khan, Maha Abdulla Alwaili, et al. "Sero-prevalence and Associated Complications of Hepatitis B Virus Infected Patients of Khyber Pakhtunkhwa." Pakistan Journal of Medical and Health Sciences 15, no. 12 (2021): 3789–94. http://dx.doi.org/10.53350/pjmhs2115123789.

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Background: Hepatitis B infection is among the most significant public health challenge worldwide. The prevalence of HBV infection is common among most populations in Peshawar, including pregnant women. Objective: The present study aims to estimate the prevalence and complications associated with clinical parameters and risk factors in patients with HBV. Methodology: A total 150 patients were reported and subjected to Enzyme linked assay (ELISA) for HBeAg test and HBs-Ag by immunochromaticgraphic assay (ICT). RT-PCR assay was used for detection of HBV DNA load. A study designed Performa was us

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Oliveira, Ana Tereza Ramos de, Lísia Marcílio Rabelo, Adelson Dias Costa, and Ines Lessa. "Características da demanda por tomografia computadorizada crânio-encefálica motivos e custos dos exames." Arquivos de Neuro-Psiquiatria 50, no. 1 (1992): 91–98. http://dx.doi.org/10.1590/s0004-282x1992000100016.

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Foram levantadas as 2860 tomografias computadorizadas crânio-encefálicas (TCCE) feitas em um dos três serviços da cidade do Salvador, Brasil, sendo: caracterizados o perfil do usuário e a procedência da demanda; analisados os motivos dos exames e os custos com TCCE normais e anormais. Foram constatadas frequências altas de exames normais: (a) para o sexo feminino (66,0%) e até os 54 anos (73,0%), neste sexo (variação de exames normais entre 65 e 80%); (b) para o sexo masculino nos grupos <15, 25-34 e 35-44 anos (64,7%); (c) para solicitações efetuadas pelos convênios (65,3%); (d) pelos segu

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Валиев, Всеволод Сергеевич, Денис Евгеньевич Шамаев, Рустам Равилевич Хасанов та Виталий Викторович Маланин. "ПОДВИЖНОСТЬ ТЯЖЕЛЫХ МЕТАЛЛОВ В ДОННЫХ ОТЛОЖЕНИЯХ И ОСОБЕННОСТИ ИНТЕРПРЕТАЦИИ ЕЕ ИЗМЕНЧИВОСТИ". Российский журнал прикладной экологии, № 2 (6 липня 2022): 61–67. http://dx.doi.org/10.24852/2411-7374.2022.2.61.67.

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При оценке подвижности тяжелых металлов в системе «вода – донные отложения» важно не только понимать условия и особенности фазовых переходов, но и иметь надежные критерии для их оценки и интерпретации. Среди факторов иммобилизации металлов в донных отложениях обычно рассматривают присутствие в них органического вещества и тонкодисперсных фракций и pH среды. Целью исследования явилось построение репрезентативных моделей такой взаимосвязи. Список литературы  Бреховских В.Ф. Тяжёлые металлы в донных отложениях Нижней Волги и дельты реки // Вода: химия и экология. 2010. №2. С. 2‒

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Kindler, H. L., D. Niedzwiecki, D. Hollis, et al. "A double-blind, placebo-controlled, randomized phase III trial of gemcitabine (G) plus bevacizumab (B) versus gemcitabine plus placebo (P) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis of Cancer and Leukemia Group B (CALGB." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4508. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4508.

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4508 Background: In a phase II trial in 52 PC pts, GB yielded a 21% response rate and a median survival of 8.8 months (mo) (Kindler, JCO 2005). These data led CALGB to conduct a phase III trial of GB vs. GP in advanced PC pts. Methods: This randomized trial was double-blind, placebo-controlled. Eligible pts had no prior therapy for advanced disease, PS 0–2, no tumor invasion of adjacent organs, no increased bleeding risk. Primary endpoint: overall survival (OS). Stratification: PS (0/1 or 2), disease extent (locally advanced or metastatic), prior radiation (RT) (yes/no). Statistics: 90% power

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Al-Maghrabi, Jaudah, Lada Vorobyova, A. Toi, William Chapman, Maria Zielenska, and Jeremy A. Squire. "Identification of Numerical Chromosomal Changes Detected by Interphase Fluorescence In Situ Hybridization in High-Grade Prostate Intraepithelial Neoplasia as a Predictor of Carcinoma." Archives of Pathology & Laboratory Medicine 126, no. 2 (2002): 165–69. http://dx.doi.org/10.5858/2002-126-0165-ionccd.

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Abstract Context.—High-grade prostate intraepithelial neoplasia (HPIN) is the most likely precursor of prostate cancer. The condition of many patients with a diagnosis of HPIN in prostate needle core biopsy could, if left untreated, progress to invasive cancer. Currently there is no available clinical, immunohistochemical, or morphologic criteria that are predictive of this progression. Objective.—To determine whether chromosomal instability in these precursor lesions could increase their predictive value for cancer detection. Design.—Dual-color interphase fluorescence in situ hybridization an

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