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Journal articles on the topic '814/.54 b'

Author: Grafiati

Published: 28 July 2024

Last updated: 31 July 2025

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1

Bos, R., T. Jansen, I. Bridges, S. De Jong, and M. Vis. "AB0884 Disease outcomes in patients with psoriatic arthritis completing 12 months of apremilast treatment - Real-world data from the REWARD study." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1565–66. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1124.

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BackgroundPatients with moderately active psoriatic arthritis (PsA) and limited joint involvement have considerable disease burden1,2. Recent data shows these patients have a high likelihood of achieving treatment goals if treated with apremilast3. This is the first report of outcomes in patients with PsA who received apremilast for 12 months in Dutch clinical practice.ObjectivesWe report disease outcomes, including the PsA Impact of Disease (PsAID) 12-item questionnaire, swollen joint count (SJC), tender joint count (TJC), dactylitis and enthesitis, among patients in the prospective, multicen

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WILLIAMS, NICOLE C., and STEVEN C. INGHAM. "Thermotolerance of Escherichia coli O157:H7 ATCC 43894, Escherichia coli B, and an rpoS-Deficient Mutant of Escherichia coliO157:H7 ATCC 43895 Following Exposure to 1.5% Acetic Acid." Journal of Food Protection 61, no. 9 (1998): 1184–86. http://dx.doi.org/10.4315/0362-028x-61.9.1184.

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On a beef carcass, Escherichia coli may sequentially encounter acid- and heat-intervention steps. This study tested whether acid stress (1.5% [vol/vol] acetic acid, pH 4.0, 37°C, 15 min) would enhance subsequent heat resistance of E. coli. Initially, cells (E. coli O157:H7 ATCC 43894, nonpathogenic E. coli B [strain FRIK-124], and rpoS-deficient mutant 813-6 [derived from E. coli O157:H7 ATCC 43895]) were acid stressed and transferred to 54°C tiypticase soy broth (TSB), and survivors were immediately enumerated after at least three intervals of 12, 2, and 6 min, respectively, by plating. The A

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Venkatesh, V. C., B. C. Planer, M. Schwartz, J. N. Vanderbilt, R. T. White, and P. L. Ballard. "Characterization of the promoter of human pulmonary surfactant protein B gene." American Journal of Physiology-Lung Cellular and Molecular Physiology 268, no. 4 (1995): L674—L682. http://dx.doi.org/10.1152/ajplung.1995.268.4.l674.

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Pulmonary surfactant protein B (SP-B) is required for normal surfactant function and for survival at birth. To further study SP-B gene expression, we sequenced genomic clones and examined promoter activity of SP-B DNA fragments by transient transfection. A plasmid construct containing human SP-B fragment -1039/+431 linked to chloramphenicol acetyltransferase (CAT) reporter gene was readily expressed in H441 cells, which are derived from a human lung adenocarcinoma, but was < 4% as active in Hep G2, HeLa, and Calu 6 cell lines. SP-B promoter activity in H441 cells was orientation dependent a

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Hasonova, L., I. Trcka, V. Babak, Z. Rozsypalova, R. Pribylova, and I. Pavlik. "Distribution of Mycobacterium avium subsp.paratuberculosis in tissues of naturally infected cattle as affected by age." Veterinární Medicína 54, No. 6 (2009): 257–69. http://dx.doi.org/10.17221/54/2009-vetmed.

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ABSTRACT: The objectives of this study were to investigate <i>Mycobacterium avium</i> subsp.<i> paratuberculosis</i> (<i>MAP</i>) distribution in various tissues, in faeces and in milk samples from 131 animals originating from one imported Jersey cattle herd from Denmark. <i>MAP</i> was detected by culture in 37.4% animals. Massive <i>MAP</i> growth was most often observed in the small intestines (48 animals). The lowest levels of <i>MAP</i> were found in spleen and mammary gland samples. <i>MAP</i> was detecte

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Dorofieieva, O. E., K. S. Yarymbash, O. A. Glinyana, Yu V. Syomych, and I. T. Skrypchenko. "Rehabilitation diagnosis of patients with mine-explosive wounds of the lower leg based on the international classification of functioning, disability and health." Medicni perspektivi 28, no. 2 (2023): 143–49. http://dx.doi.org/10.26641/2307-0404.2023.2.283384.

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Mine-explosive wounds at the level of the lower leg are accompanied by significant functional disorders, leading to long-term disability, and in some cases – to disability. The introduction at the state level of the document of the International Classification of Functioning, Disabilities and Health (ICF) in the treatment and rehabilitation process of medical institutions, necessitates its detailed study and application for making a rehabilitation diagnosis of patients. The aim of this study is to improve the process of rehabilitation diagnosis of patients with mine-explosive wounds of the low

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Dorofieieva, O.E., K.S. Yarymbash, O.A. Glinyana, Yu.V. Syomych, and I.T. Skrypchenko. "Rehabilitation diagnosis of patients with mine-explosive wounds of the lower leg based on the international classification of functioning, disability and health." Medicni perspektivi 28, no. 2 (2023): 143–49. https://doi.org/10.26641/2307-0404.2023.2.283384.

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Mine-explosive wounds at the level of the lower leg are accompanied by significant functional disorders, leading to long-term disability, and in some cases – to disability. The introduction at the state level of the document of the International Classification of Functioning, Disabilities and Health (ICF) in the treatment and rehabilitation process of medical institutions, necessitates its detailed study and application for making a rehabilitation diagnosis of patients. The aim of this study is to improve the process of rehabilitation diagnosis of patients with mine-explosive wounds of t

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Chu, Charles C., Stephanie T. Reese, Leslie O. Goodwin, et al. "Is Elevated Serum IL-10 in B-CLL Associated with IL-10 Promoter Polymorphisms?." Blood 106, no. 11 (2005): 1198. http://dx.doi.org/10.1182/blood.v106.11.1198.1198.

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Abstract Interleukin-10 (IL-10), a cytokine that regulates inflammation, may play an important role in B-cell chronic lymphocytic leukemia (B-CLL), because of the reported association of high serum IL-10 levels with a lower prognosis of survival. Using the Bio-Plex protein array system, we confirmed that B-CLL patients exhibit higher median IL-10 levels (3.54 pg/ml, n=50) as compared to controls (1.28 pg/ml, n=33) (p&lt;0.0001). We are in the midst of determining B-CLL VH gene mutation status and IL-10 levels. To determine if elevated IL-10 levels are due to inherent genetic polymorphisms,

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นวมถนอม, อนุตตรา, เจนจิรา ภูริรักษ์พิติกร та ฐิติพร วัฒนกุล. "การตรวจสอบสมบัติทางเคมีและทางกายภาพของน้ำมันงาด้วยเทคนิค นิวเคลียร์แมคเนติกเรโซแนนส์สเปก โตรสโคปี และ Accelerated Oxidation Test". วารสารวิทยาศาสตร์ประยุกต์ กรมวิทยาศาสตร์บริการ 5, № 5 (2016): 65–70. http://dx.doi.org/10.60136/bas.v5.2016.283.

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งานวิจัยนี้เป็นการศึกษาองค์ประกอบของกรดไขมัน (fatty acid) ในน้ำมันงาขาว งาดำ งาขี้ม้อนแท้ (A และ B) และน้ำมันขี้ม้อนปลอมแปลง (C) ที่ผลิตในประเทศไทย ด้วยเทคนิค โปรตรอน-นิวเคลียร์แมคเนติกเรโซแนนส์สเปกโตรสโคปี (1H-NMR) ที่ 400 MHz ผลจากการศึกษาพบว่า ปริมาณกรดไขมันชนิด oleic (O) linoleic (L) linolenic (Ln) และ saturated (S) ในน้ำมันงาทั้ง 4 ชนิดมีค่าดังนี้ น้ำมันงาดํา มีปริมาณ O ร้อยละ 41 มีปริมาณL ร้อยละ 42 และมีปริมาณ S ร้อยละ 17 น้ำมันงาขาว มีปริมาณ O ร้อยละ 39 มีปริมาณ L ร้อยละ 43 และมีปริมาณ S ร้อยละ 18 น้ำมันงาขี้ม้อน (A และ B) มีปริมาณ O ระหว่างร้อยละ 14-15 มีปมาณ L ระหว่างร้อยละ 11-13 มีปร

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Guo, Yi-Qing, Zhen Tian, and Chao Jin. "SPATIAL-DEPENDENT PROPAGATION OF COSMIC RAYS RESULTS IN SPECTRUM OF PROTON, RATIOS OF $\bar{p}/p$, B/C AND ANISOTROPY OF NUCLEI." Astrophysical Journal 819, no. 1 (2016): 54. http://dx.doi.org/10.3847/0004-637x/819/1/54.

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Gutiérrez Castro, Bleenis, José Luis Fernández, Federico Cassella, Andrés Wonaga, and Luis Viola. "Adenoma Detection Rate at Different Age Intervals Suggests Starting Colorectal Cancer Screening at 45 Years of Age." Acta Gastroenterológica Latinoamericana 53, no. 1 (2023): 59–67. http://dx.doi.org/10.52787/agl.v53i1.292.

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Introduction. It is uncertain whether starting screening at 45 years old would improve colorectal cancer prevention and currently available studies in adults younger than 50 years old are limited. Aim. To evaluate the adenoma detection rate at different age intervals. Materials and methods. Colonoscopies performed on adult outpatients were analyzed. Adenoma detection was recorded in the total population and in patients with screening indication. First, patients were divided into two groups: 50 years or older (group A) and younger than 50 years (group B). Then, we analyzed the different age seg

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Tam, Tran Thi Minh, Nguyen Thuy Linh, Phan Ha My, and Nguyen Thi Lan Anh. "Characteristics allelic of Human Leukocyte Antigen class I genotype and association with viral load and CD4 cell count in HIV-1 infected patients, Hanoi 2014 – 2016." Tạp chí Y học Dự phòng 31, no. 4 (2021): 43–50. http://dx.doi.org/10.51403/0868-2836/2021/335.

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Human Leukocyte Antigen (HLA) class I plays a regulatory role in cellular immune response to HIV-1 infection. The role of HLA alleles in HIV progression via viral load and CD4 cell count is well known. HLA class I is polymorphic and distributed differently by nation. This descriptive cross-sectional study was performed on 303 HIV-1 infected patients in 2014 - 2016, with aims to (i) characterize HLA class I genotype with 4-digit nomenclature and (ii) identify specifc alleles in correlate with CD4 cell counts and HIV viral load. 117 allele genotypes have been identifed, including 28 HLA-A allele

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Diakité, Mamadou. "Pediatrics in the Maternity Unit at the Teaching Hospital Gabriel Touré of Mali: Results of a Year of Activities." Pediatrics & Neonatal Biology Open Access 4, no. 3 (2019): 1–5. http://dx.doi.org/10.23880/pnboa-16000144.

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Introduction : Pediatrics in maternity unit is a particular mode of practice of neonatology, which cannot be reduced to the simple transposition, in an obstetric environment, of neonatal practice performed in a pediatric environment, let alone in a neonatal resuscitation environment. Methodology : It was a retrospective study over 12 months from January 1 st to December 31 st , 2018. Data were collected from birth records, newborn resuscitation and newborn follow - up registers. The variables studied were the indication of the call for a pediatrician, the delivery route, the pediatrician's act

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Reinson, Tina, Christopher D. Byrne, Janisha Patel, Magdy El-Gohary, and Michael Moore. "Transient elastography in patients at risk of liver fibrosis in primary care: a follow-up study over 54 months." BJGP Open 5, no. 6 (2021): BJGPO.2021.0145. http://dx.doi.org/10.3399/bjgpo.2021.0145.

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BackgroundLiver fibrosis assessment services using transient elastography are growing in primary care. These services identify patients requiring specialist referral for liver fibrosis, and provide an opportunity for recommending lifestyle change. However, there are uncertainties regarding service design, effectiveness of advice given, and frequency of follow-up.AimTo assess the following: (a) effectiveness of standard care lifestyle advice for weight management and alcohol consumption; (b) uptake for liver rescan; and (c) usefulness of a 4.5-year time interval of rescanning in monitoring prog

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Franson, Kyle, Brendan P. Bowler, Yifan Zhou, et al. "Astrometric Accelerations as Dynamical Beacons: A Giant Planet Imaged inside the Debris Disk of the Young Star AF Lep." Astrophysical Journal Letters 950, no. 2 (2023): L19. http://dx.doi.org/10.3847/2041-8213/acd6f6.

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Abstract We present the direct-imaging discovery of a giant planet orbiting the young star AF Lep, a 1.2 M ⊙ member of the 24 ± 3 Myr β Pic moving group. AF Lep was observed as part of our ongoing high-contrast imaging program targeting stars with astrometric accelerations between Hipparcos and Gaia that indicate the presence of substellar companions. Keck/NIRC2 observations in L ′ with the vector vortex coronagraph reveal a point source, AF Lep b, at ≈340 mas, which exhibits orbital motion at the 6σ level over the course of 13 months. A joint orbit fit yields precise constraints on the planet

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Intragumtornchai, Tanin, Udomsak Bunworasate, Thanyaphong Na Nakorn, and Ponlapat Rojnuckarin. "Alemtuzumab in Combination with CHOP and ESHAP as First-Line Treatment in Peripheral T-Cell Lymphoma." Blood 108, no. 11 (2006): 4740. http://dx.doi.org/10.1182/blood.v108.11.4740.4740.

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Abstract Patients diagnosed with peripheral T-cell lymphomas (PTCL) generally had a poorer prognosis compared to B-cell non-Hodgkin’s lymphomas. With conventional treatment, the 5-year overall and failure-free survivals (OS and FFS) were 36% and 23%, respectively (Vose et al, Blood2005;106:abstract 811). Between February 2005 and January 2006, 13 consecutive patients newly diagnosed with PTCL (5, extranodal nasal NK/T-cell lymphoma, 4 subcutaneous panniculitis-like, 3 PTCL, unspecified and 1 enteropathy type) were enrolled. The median age was 44 years (range, 21–56) and male:female was 1.6:1.

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Zayan Ibrahim, Mohammed, Amr Farouk Mohamed Abdel-Rahman, and Hany El Zahlawy. "Zero-profile implant versus integrated cage-plate implant in treatment of single level cervical disc disease." Acta Orthopaedica Belgica 88, no. 2 (2022): 285–91. http://dx.doi.org/10.52628/88.2.7727.

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The aim of this retrospective study is to evaluate and compare the clinical and radiological results of the use of Zero-P implant and the integrated cage-plate implant in surgical treatment of single level cervical disc disease. It includes 54 consecutive patients who underwent single level anterior cervical discectomy and fusion. The patients were divided into 2 groups. Group (A) including 28 patients operated with zero- profile implant and group (B) including 26 patients operated with integrated cage-plate implant. Mean operative time, blood loss, incidence of dysphagia and any other complic

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Kambhampati, Swetha, Kelly Bauer, Jimmy Hwang, Andrea Grace Bocobo, John Dozier Gordan, and Robin Kate Kelley. "Nivolumab in advanced hepatocellular carcinoma (HCC) and Child Pugh B (CPB) cirrhosis: Safety and clinical outcomes in a retrospective case series." Journal of Clinical Oncology 36, no. 4_suppl (2018): 496. http://dx.doi.org/10.1200/jco.2018.36.4_suppl.496.

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496 Background: HCC patients (pts) with Child Pugh B (CPB) cirrhosis have poor prognosis and limited treatment (Tx) options. Nivolumab demonstrated durable responses and acceptable safety in Child Pugh A (CPA) HCC in the CheckMate-040 trial with rates of hepatotoxicity similar to non-HCC populations. The safety and efficacy of nivolumab has not been established in pts with CPB cirrhosis. Methods: Design: Retrospective case series with IRB approval. Key eligibility: HCC with CPB cirrhosis; treated with nivolumab as standard Tx; enrolled in the UCSF Hepatobiliary Tissue Bank and Registry. Study

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Allaw, Mohammed B., Jeffrey M. Switchenko, Lana Khalil, et al. "Comparing Somatostatin Analogs in the Treatment of Advanced Gastroenteropancreatic Neuroendocrine Tumors." Oncology 100, no. 3 (2022): 131–39. http://dx.doi.org/10.1159/000519605.

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<b><i>Background:</i></b> The 2 approved somatostatin analogs (SSAs) in the first-line treatment of advanced, well-differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are octreotide long-acting release (Sandostatin LAR) and somatuline depot (Lanreotide). The study’s objective was to compare progression-free survival (PFS) and overall survival (OS) of patients (pts) with GEP-NETs treated with somatuline or octreotide LAR. <b><i>Pts and Methods:</i></b> Pts with advanced well-differentiated GEP-NET who received either SSA at Emor

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Siebelmann, Sebastian. "Zusammenhänge zwischen seriellen intravitrealen Anti-VEGF-Injektionen und trockenem Auge." Kompass Ophthalmologie 9, no. 3 (2023): 105–6. http://dx.doi.org/10.1159/000533341.

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<b>Purpose:</b> To investigate the effects of serial intravitreal injections (IVIs) on the ocular surface and meibomian glands (MGs) in patients treated with anti-vascular endothelial growth factor (anti-VEGF) for neovascular age-related macular degeneration (nAMD). <b>Design:</b> Retrospective, controlled, observational study. <b>Participants:</b> Patients with nAMD receiving unilateral IVIs with anti-VEGF agents. The fellow eye was used as control. <b>Methods:</b> Tear film and ocular surface examinations were performed on a single occasion at

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Zhong, Xiongping, Fuqun Wang, Dehui Zeng, Yijin Chen, and Shengbing Wang. "Study on the Effect of Different Endoscopic Auxiliary Treatment of Gastric Mucosal Microtumor." Evidence-Based Complementary and Alternative Medicine 2022 (October 11, 2022): 1–4. http://dx.doi.org/10.1155/2022/2557952.

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Objective. To explore the effect of endoscopy in the treatment of gastric mucosal microtumors. Methods. A total of 229 patients with gastric mucosal microtumors were treated in our hospital from January 2016 to December 2021. All patients were divided into three groups group A, group B, and group C. Group A was treated with a transparent cap combined with circle-assisted endoscopic resection, group B with ligator combined with circle-assisted endoscopic resection, and group C with endoscopic mucosal tumor resection. The effects of the three groups were observed. Results. There were 47 patients

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Neubauer, Aljoscha, Susanne Guthoff-Hagen, Jacob Menzler, Carsten Schwenke, Markus Rueckert, and Axel Boehnke. "VP46 German Claims Data In Rare Disease HTA: Diffuse Large B-cell Lymphoma." International Journal of Technology Assessment in Health Care 35, S1 (2019): 87. http://dx.doi.org/10.1017/s0266462319003143.

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IntroductionIn rare disease areas representative data are scarce. Routine sick fund claims data provide a meaningful and reliable base for the in- and outpatient treatment landscape. This real-world data (RWE) from Germany was used to describe treatment patterns for Diffuse Large B-cell Lymphoma (DLBCL), the most frequent and aggressive non-Hodgkin lymphoma type in adults.MethodsClaims data from several sick funds of 4.8 Million insured were analyzed. Diagnosis of non-follicular Lymphoma (C83) was confirmed in 2.178 patients, DLBCL (C83.3) in 819 patients. The analysis was age- and gender-adju

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Zhang, L., D. J. Jacob, K. F. Boersma, et al. "Transpacific transport of ozone pollution and the effect of recent Asian emission increases on air quality in North America: an integrated analysis using satellite, aircraft, ozonesonde, and surface observations." Atmospheric Chemistry and Physics Discussions 8, no. 2 (2008): 8143–91. http://dx.doi.org/10.5194/acpd-8-8143-2008.

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Abstract. We use an ensemble of aircraft, satellite, sonde, and surface observations for April–May 2006 (NASA/INTEX-B aircraft campaign) to better understand the mechanisms for transpacific ozone pollution and its implications for North American air quality. The observations are interpreted with a global 3-D chemical transport model (GEOS-Chem). OMI NO2 satellite observations constrain Asian anthropogenic NOx emissions and indicate a factor of 2 increase from 2000 to 2006 in China. Satellite observations of CO from AIRS and TES indicate two major events of Asian transpacific pollution during I

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Petrova, Penka, Alexander Arsov, Ivan Ivanov, Lidia Tsigoriyna, and Kaloyan Petrov. "New Exopolysaccharides Produced by Bacillus licheniformis 24 Display Substrate-Dependent Content and Antioxidant Activity." Microorganisms 9, no. 10 (2021): 2127. http://dx.doi.org/10.3390/microorganisms9102127.

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Bacillus licheniformis is a soil bacterium with many industrial applications. In addition to enzymes, platform chemicals, antibiotics and phytohormones, the species produces exopolysaccharides (EPSs) of various biological activities. This study revealed that Bulgarian isolate B. licheniformis 24 produced EPSs consisting of galactose, glucose and mannose with substrate-dependent ratio. From glucose, B. licheniformis 24 secreted EPS1, consisting of 54% galactose, 39% glucose and 7% mannose. From fructose, the strain formed EPS2, containing 51% glucose, 30% mannose and 19% galactose. Batch cultiv

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Zhen, Junhui, Le Zhang, Jiachao Pan та ін. "AIM2 Mediates Inflammation-Associated Renal Damage in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1, IL-1β, and IL-18". Mediators of Inflammation 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/190860.

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Background & Aims. AIM2 plays an important role in innate immunity, but its role in regulating the immune response to hepatitis B virus (HBV) is unknown. We hypothesized that AIM2 expression is positively correlated with HBV-mediated inflammation in patients with HBV-associated glomerulonephritis (HBV-GN), potentiating inflammation and leading to renal damage. We therefore analyzed the expression of AIM2 and inflammatory factors in HBV-GN tissues and cell lines relative to the inflammatory response to HBV infection and HBV status.Methods. Seventy-nine patients with chronic nephritis (CN) w

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Rahayu, Sri, Handojo Hadi Nurjanto, and Rahman Gilang Pratama. "Karakter Jamur Ceratocystis sp. Penyebab Penyakit Busuk Batang pada Acacia decurrens dan Status Penyakitnya di Taman Nasional Gunung Merapi, Yogyakarta." Jurnal Ilmu Kehutanan 9, no. 2 (2016): 94. http://dx.doi.org/10.22146/jik.10193.

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Acacia decurrens merupakan salah satu jenis tanaman yang tumbuh mendominasi kawasan Taman Nasional Gunung Merapi (TNGM), pasca erupsi Gunung Merapi tahun 2010. Sekitar 80% tegakan A. decurrens di kawasan tersebut menunjukkan gejala busuk batang akibat infeksi jamur Ceratocystis sp. yang umumnya dipicu oleh luka gerekan kumbang dari kelompok ambrosia. Penelitian bertujuan untuk : (1) mendeskripsikan karakter morfologi jamur Ceratocystis sp., serta kemampuannya beradaptasi pada beberapa jenis tanaman hutan, (2) mengevaluasi status penyakit busuk batang oleh jamur Ceratocystis sp. Karakter morfol

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Fakih, Mohamad G., Karen Jones, Janice E. Rey, et al. "Sustained Improvements in Peripheral Venous Catheter Care in Non–Intensive Care Units: A Quasi-Experimental Controlled Study of Education and Feedback." Infection Control & Hospital Epidemiology 33, no. 5 (2012): 449–55. http://dx.doi.org/10.1086/665322.

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Background and Objectives.Peripheral venous catheters (PVCs) can be associated with serious infectious complications. We evaluated the effect of education and feedback on process measures to improve PVC care and infectious complications.Design.Quasi-experimental controlled crossover study with sampling before and after education.Setting.An 804-bed tertiary care teaching hospital.Participants.Nurses and patients in 10 non-intensive care units.Methods.We implemented a process to improve PVC care in 10 non-intensive care units. The 4 periods (each 3 months in duration) included a preintervention

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Faiz, Mohd Ali, Chuan Hun Ding, Asrul Abdul Wahab, et al. "The Antibiotic Resistance Profile of Pseudomonas Aeruginosa in a Tertiary Medical Center from Malaysia." Journal of Medicine 23, no. 1 (2022): 54–60. http://dx.doi.org/10.3329/jom.v23i1.57938.

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Background: Pseudomonas aeruginosa is a notorious gram-negative bacterium that has become a globalpublic health concern owing to the emergence of multi- and pandrug-resistant strains. This study sought todetermine the antibiotic susceptibility profile of P. aeruginosa in a tertiary medical center from Malaysia. Materials and Methods: Each isolate’s identity was confirmed using the VITEK 2 GN kit, and subjectedto antibiotic susceptibility testing using the VITEK 2 AST-N374 card (for testing against piperacillintazobactam,ceftazidime, cefepime, imipenem, meropenem, amikacin, gentamicin and cipro

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Haeili, Mehri, Arash Ghodousi, Bijan Nomanpour, Maryam Omrani, and Mohammad Mehdi Feizabadi. "Drug resistance patterns of bacteria isolated from patients with nosocomial pneumonia at Tehran hospitals during 2009-2011." Journal of Infection in Developing Countries 7, no. 04 (2013): 312–17. http://dx.doi.org/10.3855/jidc.2604.

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Introduction: Nosocomial pneumonia remains an important cause of mortality and morbidity worldwide. Surveillance programs play an important role in the identification of common etiologic agents and local patterns of antimicrobial resistance. Methodology: In this study we determined the frequency and antimicrobial susceptibility of pathogens isolated from patients with nosocomial pneumonia during 2009 to 2011. Results: A total of 642 bacteria were isolated from 516 suspected samples. Acinetobacter baumannii (21.1%, n = 136), was the commonest isolated pathogen followed by Pseudomonas aeruginosa

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Roick, Julia, Peter Esser, Beate Hornemann, Anja Mehnert, and Jochen Ernst. "Warum gerade ich? – Subjektive Krankheitsursachen und Zusammenhänge zu sozialen Faktoren und wahrgenommener Stigmatisierung bei Brust-, Prostata-, Darm- und Lungenkrebspatienten." PPmP - Psychotherapie · Psychosomatik · Medizinische Psychologie 70, no. 01 (2019): 22–31. http://dx.doi.org/10.1055/a-0851-6758.

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Zusammenfassung Hintergrund Subjektive Krankheitsursachen gehen vielfach mit Selbstbeschuldigung und Schamgefühlen einher. Diese psychosozialen Belastungen können durch mögliche Stigmatisierungserfahrungen verstärkt werden. Die vorliegende Studie untersucht Annahmen zu subjektiven Krankheitsursachen von Krebspatienten und prüft Zusammenhänge mit sozialen Faktoren und dem Grad erlebter Stigmatisierung. Methoden Im Rahmen einer bizentrischen Studie wurden 858 Patienten mit Brust-, Darm-, Lungen oder Prostatakrebs quantitativ befragt, von denen 815 in die Berechnungen eingingen. Subjektive Krankh

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Koch, Christine, Markus Göller, Eckart Schott, et al. "Combination of Sorafenib and Transarterial Chemoembolization in Selected Patients with Advanced-Stage Hepatocellular Carcinoma: A Retrospective Cohort Study at Three German Liver Centers." Cancers 13, no. 9 (2021): 2121. http://dx.doi.org/10.3390/cancers13092121.

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Background and Aims. Systemic treatment with sorafenib has been the standard of care (SOC) in patients with advanced Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) for more than a decade. TACE has been reported to allow better local tumor control in selected patients with BCLC stage C HCC. Methods. A retrospective analysis of patients with BCLC stage C HCC that were treated with sorafenib and TACE was conducted; they were compared to BCLC stage C patients treated either with TACE or sorafenib in the same period of time outside a clinical trial. Results. A total of

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Grant, Conor, Sarah O'Connell, Darren Lillis, et al. "Opt-out screening for HIV, hepatitis B and hepatitis C: observational study of screening acceptance, yield and treatment outcomes." Emergency Medicine Journal 37, no. 2 (2019): 102–5. http://dx.doi.org/10.1136/emermed-2019-208637.

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BackgroundWe initiated an emergency department (ED) opt-out screening programme for HIV, hepatitis B virus (HBV) and hepatitis C virus (HCV) at our hospital in Dublin, Ireland. The objective of this study was to determine screening acceptance, yield and the impact on follow-up care.MethodsFrom July 2015 through June 2018, ED patients who underwent phlebotomy and could consent to testing were tested for HIV, HBV and HCV using an opt-out approach. We examined acceptance of screening, linkage to care, treatment and viral suppression using screening programme data and electronic health records. Th

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Paz-Ibarra, Jose, and Oscar Quintana-Pinto. "METABOLIC CHARACTERISTICS OF PATIENTS WITH POLYCYSTIC OVARY SYNDROME IN A PERUVIAN HOSPITAL." Journal of the ASEAN Federation of Endocrine Societies 37, no. 2 (2022): 71. https://doi.org/10.15605/jafes.037.afes.111.

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OBJECTIVESTo describe the metabolic characteristics of patients with PCOS in the endocrinology service of a Peruvian hospital. METHODOLOGYDescriptive study that evaluated the clinical and metabolic characteristics of patients with PCOS in the endocrino- logy service of the Edgardo Rebagliati Martins National Hospital, Lima - Peru. RESULTSWe evaluated 100 consecutive women; age 27.2 ± 7.3 years; 4% and 7% had DM2 and hypertension, respectively. 66% had a family history of DM2, 37% hypertension, 38% obesity, and 9% early cardiovascular disease. Twelve women had macrosomic children. Their BMI: 27

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Sartori, Giulio, Filippo Spriano, Luciano Cascione, et al. "Abstract B170: The in vitro anti-tumor activity of the multi-kinase inhibitor nemtabrutinib (ARQ-531, MK-1026) is seen across multiple B-cell lymphoma subtypes, only partially overlapping with what achieved by single BTK inhibition." Molecular Cancer Therapeutics 22, no. 12_Supplement (2023): B170. http://dx.doi.org/10.1158/1535-7163.targ-23-b170.

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Abstract Background. Nemtabrutinib is a reversible, ATP competitive tyrosine kinase inhibitor of BTK and of several other kinases, including LYN and MEK1 (Reiff et al, Cancer Discov 2018). Nemtabrutinib has shown preclinical and clinical activity in chronic lymphocytic leukemia (CLL), also against tumors bearing mutations affecting the C481 amino acid of BTK (Reiff et al, Cancer Discov 2018; Eradat et al, ICML 2023), which is commonly mutated in patients treated with 1st and 2nd generation inhibitors such as ibrutinib, acalabrutinib, zanubrutinib (Thompson & Tam, Blood 2023). Based on thes

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Hanna, Nasser H., Suzanne Eleanor Dahlberg, Jill Kolesar, Fred R. Hirsch, Suresh S. Ramalingam, and Joan H. Schiller. "Three-arm randomized phase II study of carboplatin (C) and paclitaxel (P) in combination with cetuximab (CET), IMC-A12, or both for advanced non-small cell lung cancer (NSCLC) patients who will not receive bevacizumab-based therapy: An Eastern Cooperative Oncology Group (ECOG) study (E4508)." Journal of Clinical Oncology 30, no. 15_suppl (2012): 7516. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.7516.

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7516 Background: Pre-clinical evidence supports the clinical investigation of inhibitors to the insulin-like growth factor receptor (IGFR) and the epidermal growth factor receptor (EGFR) alone and in combination with one another in patients (pts) with NSCLC. Methods: Pts w/ chemotherapy-naïve, advanced NSCLC, not eligible for bevacizumab-based therapy, ECOG PS 0/1 were eligible. Pts with uncontrolled or untreated brain mets and/or severe hyperglycemia were ineligible. Pts were randomized to receive: C AUC 6 iv + P 200 mg/m2 iv on day 1 every 3 wks combined with either CET iv weekly (arm A), IM

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Allanore, Y., M. Vonk, O. Distler, et al. "POS0126 CONTINUED TREATMENT WITH NINTEDANIB IN PATIENTS WITH SYSTEMIC SCLEROSIS-ASSOCIATED INTERSTITIAL LUNG DISEASE (SSC-ILD): THREE-YEAR DATA FROM SENSCIS-ON." Annals of the Rheumatic Diseases 82, Suppl 1 (2023): 281.1–281. http://dx.doi.org/10.1136/annrheumdis-2023-eular.2029.

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BackgroundIn the randomised placebo-controlled SENSCIS trial in patients with SSc-ILD, nintedanib reduced the rate of decline in forced vital capacity (FVC) (mL/year) over 52 weeks by 44%, with adverse events that were manageable for most patients. SENSCIS-ON is an open-label extension study investigating adverse events and decline in FVC in patients with SSc-ILD treated with nintedanib over the longer term.ObjectivesTo assess adverse events and decline in FVC in patients treated with open-label nintedanib over 148 weeks of SENSCIS-ON.MethodsIn the SENSCIS trial, patients received nintedanib o

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Hartmann, Sylvia, Sonja Scharf, Yvonne Steiner, et al. "Landscape of 4D Cell Interaction in Hodgkin and Non-Hodgkin Lymphomas." Cancers 13, no. 20 (2021): 5208. http://dx.doi.org/10.3390/cancers13205208.

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Profound knowledge exists about the clinical, morphologic, genomic, and transcriptomic characteristics of most lymphoma entities. However, information is currently lacking on the dynamic behavior of malignant lymphomas. This pilot study aimed to gain insight into the motility of malignant lymphomas and bystander cells in 20 human lymph nodes. Generally, B cells were faster under reactive conditions compared with B cells in malignant lymphomas. In contrast, PD1-positive T cells did not show systematic differences in velocity between reactive and neoplastic conditions in general. However, lympho

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Toledo, Guillermo, Verónica Gargaglione, Pablo Luis Peri, and Santiago Toledo. "Biomasa y respiración microbiana: Respuesta ante cambios en la humedad del suelo en la Estepa Magallánica Seca de Santa Cruz, Argentina." Informes Científicos Técnicos - UNPA 12, no. 3 (2020): 151–65. http://dx.doi.org/10.22305/ict-unpa.v12.n3.746.

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El carbono y el nitrógeno de la biomasa microbiana (CBM y NBM) del suelo son bioindicadores que tienen el potencial de mostrar cambios en el suelo de los ecosistemas, y están condicionados por la humedad disponible en el suelo. Se evaluó como varían CBM, NBM y la respiración heterotrófica (RH) en función de la cantidad de humedad en suelos de la Estepa Magallánica Seca de Santa Cruz, Argentina. El ensayo consistió en 3 tratamientos: a) Control, conteniendo la precipitación normal caída, como testigo, b) Riego, equivalente a un aumento del 54% en las precipitaciones respecto a la media anual, y

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Manesis, Emanuel K., Maria Schina, Frédéric Le Gal, et al. "Quantitative Analysis of Hepatitis D Virus RNA and Hepatitis B Surface Antigen Serum Levels in Chronic Delta Hepatitis Improves Treatment Monitoring." Antiviral Therapy 12, no. 3 (2006): 381–88. http://dx.doi.org/10.1177/135965350701200307.

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Background/aims Treatment of chronic delta hepatitis is long and difficult and better monitoring is needed. Methods In this study, hepatitis delta virus (HDV) RNA, hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA were retrospectively quantified in 53 patients with hepatitis B e antigen (HBeAg)-negative chronic hepatitis delta. Twenty-one had received 28 courses of 3–5 MU interferon-α2b (IFN-α2b) thrice weekly for a median of 12.6 months (interquartile range [IQR]: 7.3–31.6), five had received eight courses of 100 mg lamivudine (LAM) daily for 23.6 months (IQR: 8.4–61.5) and

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Rosa, Nicola, Maddalena De Bernardo, Giulia Abbinante, Gianluca Vecchio, Ferdinando Cione, and Luigi Capasso. "Optic Nerve Drusen Evaluation: A Comparison between Ultrasound and OCT." Journal of Clinical Medicine 11, no. 13 (2022): 3715. http://dx.doi.org/10.3390/jcm11133715.

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This observational study compared optic coherence tomography (OCT) and B-scan in the detection of optic disc drusen. In total, 86 eyes of 50 patients with optic disc drusen (ODD) (36 bilateral) with a mean age of 34.68 ± 23.81 years, and 54 eyes of 27 patients with papilledema, with a mean age of 35.42 years ± 17.47, were examined. Patients with ODD, diagnosed with ultrasound, underwent spectral-domain OCT evaluation. With US, 28 ODD cases were classified as large (4 buried and 24 superficial), 58 were classified as point-like (6 buried, 49 superficial and 3 mixed). Then, all patients underwen

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Park, Jin Kyun, Min Ah Lee, Eun Young Lee, et al. "Effect of methotrexate discontinuation on efficacy of seasonal influenza vaccination in patients with rheumatoid arthritis: a randomised clinical trial." Annals of the Rheumatic Diseases 76, no. 9 (2017): 1559–65. http://dx.doi.org/10.1136/annrheumdis-2017-211128.

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ObjectiveTo investigate whether temporary discontinuation of methotrexate (MTX) improves the efficacy of seasonal influenza vaccination in patients with rheumatoid arthritis (RA).MethodsIn this prospective randomised parallel-group trial, patients with RA taking stable dose of MTX were randomly assigned at a ratio of 1:1:1:1 to continue MTX (group 1), suspend MTX for 4 weeks before vaccination (group 2), suspend MTX for 2 weeks before and 2 weeks after vaccination (group 3) or suspend MTX for 4 weeks after vaccination (group 4). All participants were vaccinated with trivalent influenza vaccine

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Almeida, Antonio Vanklane de, Alexsandro Oliveira Silva, Jenyffer da Silva Gomes Santos, Janiquelle da Silva Rabello, Valsergio Barros da Silva, and Alfredo Mendonça de Sousa. "RESPOSTA DA CULTURA DO RABANETE SOB CULTIVO ORGÂNICO AOS FATORES DE PRODUÇÃO ÁGUA E COBERTURA DO SOLO." IRRIGA 26, no. 1 (2021): 42–54. http://dx.doi.org/10.15809/irriga.2021v26n1p42-54.

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RESPOSTA DA CULTURA DO RABANETE SOB CULTIVO ORGÂNICO AOS FATORES DE PRODUÇÃO ÁGUA E COBERTURA DO SOLO ANTONIO VANKLANE DE ALMEIDA1; ALEXSANDRO OLIVEIRA DA SILVA1; JENYFFER DA SILVA GOMES SANTOS2; JANIQUELLE DA SILVA RABELO3; VALSERGIO BARROS DA SILVA1 E ALFREDO MENDONÇA DE SOUSA1 1 Departamento de Engenharia Agrícola, Universidade Federal do Ceará, UFC, Av. Mr. Hull, s/n, Pici, CEP:60356-001, bloco 804, Fortaleza, Ceará, Brasil. E-mail: vanklaneprece@hotmail.com, alexsandro@ufc.br, valsergiobarros@hotmail.com, alfredomendonca121@gmail.com 2 Faculdade de Engenharia Agrícola, Universidade Estadu

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Pipe, Steven, Paul van der Valk, Peter Verhamme, et al. "Long-Term Bleeding Protection, Sustained FIX Activity, Reduction of FIX Consumption and Safety of Hemophilia B Gene Therapy: Results from the HOPE-B Trial 3 Years after Administration of a Single Dose of Etranacogene Dezaparvovec in Adult Patients with Severe or Moderately Severe Hemophilia B." Blood 142, Supplement 1 (2023): 1055. http://dx.doi.org/10.1182/blood-2023-187624.

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Introduction: Etranacogene dezaparvovec (formerly AMT-061) is the first approved gene therapy for hemophilia B in the US and Europe. It is an adeno-associated virus serotype 5 (AAV5) vector containing a codon-optimized, highly active factor IX (FIX) Padua R338L transgene under the control of the liver-specific promoter LP-1. The pivotal phase 3 HOPE-B clinical trial (NCT03569891) of etranacogene dezaparvovec demonstrated superiority of bleeding protection compared to standard of care FIX prophylaxis up to 24 months post-treatment; long-term follow-up from Year 2 post-administration onward is c

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Toh, H., Y. P. Phoon, R. Quek, A. H. Banham, and S. Y. Tan. "Increased foxp3+ regulatory T cells predicts for superior relapse-free and overall survival in early stage hepatocelullar carcinoma." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4642. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4642.

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4642 Background: Hepatocellular carcinoma (HCC) endemic in Asia is aggressive and mainly hepatitis B-related. In ovarian and breast cancer, higher levels of foxp3+ regulatory T cells predicts for a poorer clinical outcome. The reverse is true with follicular lymphoma and Hodgkin’s disease. We hypothesize that foxp3+ CD4+ regulatory T lymphocyte (Treg) frequency predicts for clinical outcome in HCC. We also examined the recently identified IL17-producing, RORγt-expressing, CD4+ pathogenic Th17 cells in HCC. Methods: We analyzed Treg cells (n=116) and CD8+ T cells (n=24) expression by CD3/Foxp3

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Karliychuk, M. A., P. A. Bezditko, and S. V. Pinchuk. "Changes of Morphometric Parameters of the Macula as a Non-Invasive Biomarker of the Severity of Diabetic Polyneuropathy." Ukrainian journal Ophthalmology, no. 2(13) (June 2021): 14–23. http://dx.doi.org/10.30702/ophthalmology30062021-13.2.14-23/833-007.17.

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Diabetic polyneuropathy (DPN) is one of the most common complications of diabetes mellitus (DM), affecting up to a quarter of all patients with DM, and in asymptomatic form it is present in all patients. A number of changes in the retina, optic nerve, corneal nerve fibers, and visual function may correlate with DPN, so their evaluation may provide additional information on the detection and determination of its severity. The aim. To determine the peculiarities of changes in morphometric parameters of the central zone of the retina depending on the severity of DPN. Materials and methods. In tot

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Kang, Chan, Jaehwang Song, Donghun Kang, Chang-Kyun Noh, and Ahn Ki Jun. "Extended Distal Chevron Osteotomy." Foot & Ankle Orthopaedics 2, no. 3 (2017): 2473011417S0002. http://dx.doi.org/10.1177/2473011417s000229.

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Category: Bunion, Midfoot/Forefoot Introduction/Purpose: Numerous corrective osteotomies have been performed for surgical treatment of hallux valgus(HV). One of these procedures is distal chevron osteotomy, traditionally indicated for correction of mild to moderate HV. We proposed a new modification of the chevron osteotomy, extended distal chevron osteotomy, to provide even greater stability by extend the contact surface, as well as more effective and accurate correction of the angulation and rotational profile than conventional osteotomy. Methods: Between July 2013 and June 2014, the extende

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Balcı, Yasemin, Gürcan Altun, and Muharrem Teyin. "2000-2004 Yılları Arasında Science Citation Index’de Taranan Türkiye Kaynaklı Adli Tıp Yayınlarının Değerlendirilmesi." Bulletin of Legal Medicine 14, no. 3 (2009): 119–25. http://dx.doi.org/10.17986/blm.2009143697.

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Bilim insanlarının kendi alanlarındaki gelişmeleri izlemeleri kadar, yapmış oldukları araştırmaları diğer araştırmacılarla paylaşmaları da önemlidir. Uzun zaman alan ve yoğun emek ürünü olan bilimsel çalışmaların sonuçlarmı, bilim insanları ile paylaşmak ve kalıcılığını sağlamak açısından en doğru yol uluslararası kabul gören seçkin dergilerde yayınlamaktır. Bu çalışmada; 2000-2004 yılları arasındaki 5 yıllık süreçte, ülkemizdeki adli tıp uzman ve asistanlarının katkılarıyla yapılan uluslararası yayınları TUBITAK-Uluslararası Bilimsel Yayınları Teşvik Programı ölçütlerine göre değerlendirmek v

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Sofiani, Yani, Abdu Rahim Kamil, and Fitrian Rayasari. "relationship between illness perceptions, self-management, and quality of life in adult with type 2 diabetes mellitus." Jurnal Keperawatan Padjadjaran 10, no. 3 (2022): 187–95. http://dx.doi.org/10.24198/jkp.v10i3.2135.

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Background: Few studies have examined the association between illness perception, self-management, and quality of life in adults with type 2 Diabetes Mellitus (DM), especially in resource-limited countries such as Indonesia. Purpose: This study aimed to evaluate the relationship between illness perception, self-management, and quality of life in adult with type 2 DM in Indonesia. Methods: The inclusion criteria were adult aged over 18 years old and diagnosed with type 2 DM. Convenience sampling was used in this study. A total of 351 patients with type 2 DM was recruited (response rate= 97.50%)

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Mirzaii-Dizgah, Iraj, Boshra Jamshidpour, Behrouz Attarbashi Moghadam, Behnoosh Vasaghi-Gharamaleki, and Mostafa Nejatian. "The Effects of Phase III Cardiac Rehabilitation in Serum and Salivary Hs-CRP and Anthropometric Measurements in Patients with Coronary Artery Disease." Journal of Contemporary Dental Practice 14, no. 5 (2013): 819–24. http://dx.doi.org/10.5005/jp-journals-10024-1409.

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ABSTRACT Aim Cardiac rehabilitation is a key part in the treatment of coronary artery disease (CAD) by its anti-inflammatory effects. However, the effect of exercise training programs on salivary concentrations of high-sensitivity C-reactive protein (hs-CRP) in patients with coronary artery disease has not been well studied. The objective of this study was to evaluate the effect of phase III cardiac rehabilitation on serum and salivary levels of hs-CRP, in relation to the anthropometric measurements of obesity and the relationship between salivary and serum levels of hs-CRP in CAD male patient

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Minoda, S., R. Sada, S. Matsushita, et al. "POS0516 REDEFINING THE CLINICAL AND LABORATORY FEATURES OF RHEUMATIC PLEURAL EFFUSION: A 30-CASE SERIES." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 492.1–492. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1197.

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Background:Rheumatoid pleural effusion (RPE) is a common extra-articular complication in patients with rheumatoid arthritis (RA). Previous studies have shown that RPE usually occurs in middle-aged men with rheumatoid factor (RF)-positive RA. RPE usually has features of pleural fluid acidosis, high lactate dehydrogenase (LDH) levels, and very low glucose levels(1). However, to the best of our knowledge, these findings were based on very few case series and reports, and most of these reports were published by the early 2000s(1, 2).Objectives:To investigate the clinical and laboratory characteris

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Kumar, Shaji K., Betsy R. Laplant, Craig B. Reeder, et al. "Randomized Phase 2 Trial of Two Different Doses of Ixazomib in Patients with Relapsed Multiple Myeloma Not Refractory to Bortezomib." Blood 126, no. 23 (2015): 3050. http://dx.doi.org/10.1182/blood.v126.23.3050.3050.

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Abstract Background: Ixazomib is an experimental, orally bioavailable, proteasome inhibitor that has demonstrated anti-tumor activity in relapsed multiple myeloma (MM). In the dose escalation studies, ixazomib was tolerated up to a dose of 5.5 mg given every week as a single agent, while a dose of 4 mg was utilized in the combination studies with lenalidomide. We undertook this study to examine the efficacy and tolerability of the two doses of ixazomib in combination with dexamethasone in patients with relapsed MM. Patients and methods: This was a randomized phase 2 study of two doses of ixazo

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