Contents
Academic literature on the topic '828.996 67'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic '828.996 67.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Journal articles on the topic "828.996 67"
1
Albaba, Hamzeh, Anna Dodd, Rebecca M. Prince, Kyaw Lwin Aung, David W. Hedley, Steven Gallinger, John Kim, et al. "Impact of an inter-professional clinic on pancreatic cancer outcomes: The Princess Margaret Cancer Centre (PM) experience." Journal of Clinical Oncology 37, no. 4_suppl (February 1, 2019): 444. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.444.
Full textAbstract:
444 Background: Patients with pancreatic ductal adenocarcinoma (PDAC) have limited treatment options. Management of complex symptoms and psychosocial implications requires an interprofessional approach as prognosis is often measured in months. A multidisciplinary approach has been associated with improvement in clinical outcomes including survival. We aimed to evaluate the impact of an inter-professional approach for PDAC patients at the Wallace McCain Centre for Pancreatic Cancer (WMCPC) at PM on their management and clinical outcomes. Methods: We undertook retrospective review of all patients with PDAC seen at PM two years before (July ‘12 – June ‘14) and two years after (July ‘14 – June ‘16) establishment of the WMCPC. Standard therapies (surgical approach, chemotherapy, radiation therapy) were the same during both time periods. Comparison of overall survival (OS), stage at diagnosis, surgical outcomes, waiting times, and proportion seen by social worker, dietician and clinical nurse specialist (CNS) was explored with descriptive statistic and survival analysis. Results: A total of 993 patients were reviewed; 482 patients pre- and 511 patients post-WMCPC. Age (median 67 yrs), sex (54% men) and stage III/IV (52%) were similar in both groups. There was a trend to improved OS in the post-WMCPC group (9.6 vs. 10.9 m; p = 0.055); multivariable analysis found a significant improvement in OS after adjustment for performance status and stage (p = 0.023; HR 0.84, 95% CI 0.72-0.98). Rate of R0 versus R1/R2 resection for curative surgery (n = 264, 28%) was similar in both groups. Time from referral to first clinic visit significantly decreased from 13.4 to 8.8 days in the post-WMCPC group (p < 0.001) as did time from first clinic appointment to diagnostic biopsy (25.9 vs. 16.9 days, p = 0.022). Patients in the post-WMCPC were more frequently seen by a social worker, dietician or CNS (8% vs. 38%, 9% vs. 35% and 31% vs. 50% respectively, p < 0.001). Conclusions: Establishment of an interprofessional clinic for the treatment of PDAC patients at PM has streamlined diagnosis, aided symptom management and improved overall survival. This has implications for planning care delivery models and proves the value of this intervention.
2
Stešević, Danijela, Željko Jaćimović, Zlatko Šatović, Aida Šapčanin, Gordan Jančan, Milica Kosović, and Biljana Damjanović-Vratnica. "Chemical Characterization of Wild Growing Origanum vulgare Populations in Montenegro." Natural Product Communications 13, no. 10 (October 2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301031.
Full textAbstract:
In order to make chemical characterization of two Origanum vulgare L. subspecies in Montenegro, the essential oils of five wild growing populations were analyzed. Among 67 oil constituents, in O. vulgare subsp. hirtum dominant one was oxygenated monoterpene carvacrol (74.3%), while in O. vulgare subsp. vulgare prevailed sesquiterpene hydrocarbons: germacrene D (15.4–27.9%) and β-caryophyllene (7.7–14.6%), and among oxygenated monoterpenes: α- terpineol (4.8–17.8%), linalyl acetate (0.5–9.6%), linalool (3.0–8.8%), thymol (0.2–8.3), terpinene 4-ol (1.5–8.3%). Several of the main essential oil constituents appeared to be highly intercorrelated. Strong positive correlations (r > 0.70; P < 0.01) were observed between α-terpineol and linalyl acetate, α-terpineol and thymol, linalyl acetate and thymol, γ-terpenene and carvacrol, ( E)-β-ocimene and β-bisabolene, while strong negative correlations (r < −0.70; P < 0.01) were evidenced between γ-terpenene and β-caryophyllene, γ-terpenene and germacrene D, p-cymene and germacrene D. Multivariate analyses allowed the grouping of the populations into three distinct chemotypes. Population P5 (Origanum vulgare subsp. hirtum) was distinguished from O. vulgare subsp. vulgare populations by predominance of carvacrol, while within the typical subspecies the population P1 (Boljevići) separated from P2 (Radovče), P3 (Lipovo) and P4 (Grahovo) by high oil levels of α-terpineol, linalyl-acetate and thymol.
3
Кручинина, М. В., В. Н. Кручинин, Г. В. Шувалов, И. В. Минин, and О. В. Минин. "Использование ЯМР и ИК спектроскопии для исследования крови в целях диагностики стадии заболевания при диффузной патологии печени." Журнал технической физики 128, no. 6 (2020): 783. http://dx.doi.org/10.21883/os.2020.06.49411.16-20.
Full textAbstract:
67 patients (mean age 48 ± 1 year) with diffuse liver diseases of various origins were examined. It has been established that an increase in the degree of fibrosis is associated with an increase in the resonance intensity of glucose-6-phosphates, adenosine monophosphate (AMP), inosine monophosphate (IMP), pyrophosphates, 2,3-DPH and a decrease in the resonances of inorganic phosphates and phosphocreatine, γ-, alpha- and beta- ATP, -UTP, Hb- and Mg-ATP, as well as beta- and alpha-ADP. The predictive value of a positive result of erythrocyte 31P NMR spectroscopy for liver fibrosis is 92.3% (sensitivity 85.71%, specificity 80%). In the IR spectra of the blood serum of patients with severe fibrosis, in contrast to moderate fibrosis, the resonance intensity is higher at 1280, 3190 and significantly lower at 776, 818, 889, 966, 1399.1450, 1570, 1635 cm-1, which indicates the presence of protein molecules with a secondary structure mainly in the form of a helix (alpha-helix) compared with the structure in the form of a folded sheet (beta-sheet) (p <0.001-0.05). The combined use of 31P NMR spectroscopy of erythrocyte suspensions and IR spectroscopy of blood serum made it possible to increase diagnostic accuracy (96%), sensitivity (97%) and specificity (91%) in distinguishing between degrees of liver fibrosis in contrast to the isolated use of these methods.
4
Preet, Mohan, Jinli Liu, Constantine A. Axiotis, Albert S. Braverman, and Gurinder Singh Sidhu. "Impact of bone marrow fibrosis (BMF) at diagnosis in patients with multiple myeloma (MM)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): e19522-e19522. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e19522.
Full textAbstract:
e19522 Background: BMF is known to occur in a minority of myeloma patients, but its incidence in American patients of African origin is not known. The impact of BMT on presenting clinical and laboratory findings, and its relationship to genetic variants has not been defined. Methods: Kings County Hospital is located in the East Flatbush section of Brooklyn, New York, where the population is mainly of African-Caribbean origin. Records and bone marrow specimens of myeloma patients who presented from 2000 through 2010 were reviewed. Degree of fibrosis was graded according to World Health Organization criteria: mild, moderate and severe. Results: Records of 113 patients were reviewed, 110 (97%) 97 of whom were African American or Caribbean; 62 (55%) were female and 51 (45%) male. Their ages ranged from 38 to 89 (median 65). Of the 27 patients with BMF (24%), 17 (63%) were female. Mild, moderate and severe BMF were present in 14 (52%), 7 (26%) and 6 (22%) patients respectively. Presentation calcium and creatinine levels were normal in all patients. Hemoglobin levels were similar (median 9.6 G/dl) in patients without BMF and in those with mild and moderate grades, the median level was 7.5 G/dl in those with severe BMF. Immunoglobulin G, A and D levels (67, 20 and 1) were similar in patients with and without BMF, but lambda light chain expression was greater in the BMF patients: 41 vs 24%. Cytogenetic data (CGD) was available in 46 patients; and abnormal in 10 (22%). All patients with abnormalities of chromosomal number were hyperdiploid. Of the 27 BMF patients CG data was available in 17, and was abnormal in 2 (12%). FISH results were normal in 23 of 25 patients, and in all of those with BMF. The fraction of the BMF and non BMF patients surviving after median follow up periods of 828 and 885 days were similar. Conclusions: BMF in this population was 24%, and severe in 5%. Female preponderance is a characteristic of MM patients of African origin, and was more marked in those with BMF. The BMF patients were characterized by more severe anemia and greater lambda light chain expression.
5
Goldstein, Bryan H., Stuart L. Goldstein, Prasad Devarajan, Farhan Zafar, David M. Kwiatkowski, Bradley S. Marino, David L. S. Morales, Catherine D. Krawczeski, and David S. Cooper. "First-stage palliation strategy for univentricular heart disease may impact risk for acute kidney injury." Cardiology in the Young 28, no. 1 (September 11, 2017): 93–100. http://dx.doi.org/10.1017/s1047951117001640.
Full textAbstract:
AbstractObjectiveNorwood palliation for patients with single ventricle heart disease is associated with a significant risk for acute kidney injury, which portends a worse prognosis. We sought to investigate the impact of hybrid stage I palliation (Hybrid) on acute kidney injury risk.DesignThis study is a single-centre prospective case–control study of seven consecutive neonates with single ventricle undergoing Hybrid palliation. Levels of serum creatinine and four novel urinary biomarkers, namely neutrophil gelatinase-associated lipocalin, interleukin-18, liver fatty acid-binding protein, and kidney injury molecule-1, were obtained before and after palliation. Acute kidney injury was defined as a ⩾50% increase in serum creatinine within 48 hours after the procedure. Data were compared with a contemporary cohort of 12 neonates with single ventricle who underwent Norwood palliation.ResultsPatients who underwent Hybrid were more likely to be high-risk candidates (86 versus 25%, p=0.01) compared with those who underwent Norwood. Despite similar preoperative serum creatinine levels, there was a trend towards higher levels of postoperative peak serum creatinine (0.7 [0.63, 0.94] versus 0.56 [0.47, 0.74], p=0.06) and rate of acute kidney injury (67 versus 29%, p=0.17) in the Norwood cohort. Preoperative neutrophil gelatinase-associated lipocalin (58.4 [11, 86.3] versus 6.3 [5, 16.2], p=0.07) and interleukin-18 (30.6 [9.6, 167.2] versus 6.3 [6.3, 16.4], p=0.03) levels were higher in the Hybrid cohort. Nevertheless, longitudinal mixed-effect models demonstrated Hybrid palliation to be a protective factor against increased postoperative levels of neutrophil gelatinase-associated lipocalin (estimate −1.8 [−3.0, −9.0], p<0.001) and liver fatty acid-binding protein (−49.3 [−89.7, −8.8], p=0.018).ConclusionsIn this single-centre case–control study, postoperative acute kidney injury risk did not differ significantly by single ventricle stage I treatment strategy; however, postoperative elevation in novel urinary biomarkers, consistent with subclinical kidney injury, was encountered in the Norwood cohort but not in the Hybrid cohort.
6
Ocean, A. J., K. O’Brien, J. Lee, N. Matthews, S. Holloway, P. Christos, T. S. Kung, A. Kaubisch, H. Chen, and S. Wadler. "Phase II trial of FOLFOX6, bevacizumab and cetuximab in patients with Colorectal Cancer." Journal of Clinical Oncology 25, no. 18_suppl (June 20, 2007): 4075. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4075.
Full textAbstract:
4075 Background: Bevacizumab (B) + FOLFOX is widely accepted as a standard first-line therapy for metastatic colorectal cancer (mCRC). Recent treatment strategies have included the use of targeted therapies combined with chemotherapy to improve efficacy and to reduce chemotherapy-related toxicities. This Phase II study assesses first-line mFOLFOX6 + B + cetuximab (C), a monoclonal antibody approved for use in irinotecan-refractory mCRC. Methods: All pts had ECOG PS = 1, normal bone marrow, hepatic and renal function. Pts received mFOLFOX6 + B (5mg/kg) biweekly and C weekly (initially at 400 mg/m2, then subsequent doses at 250 mg/m2). Tumor assessment by imaging was done every 8 weeks. Primary endpoints are response rate, progression free-survival (PFS), overall survival (OS), and safety. The regimen would be considered promising if there were = 32 responses, or if = 60% of pts were progression-free for at least 8 months. Results: 67 pts (37 males, 30 females) were enrolled from 12/04–11/06. Median age was 57. Toxicities included Grade 4: neutropenia (6%), thrombosis/embolism (5%). Grade 3: neutropenia (13%), rash (13%), fatigue (11%), diarrhea (11%), abdominal pain (6%), neuropathy (5%), infection with ≤ Grade 2 ANC (4.5%). There were 2 deaths, 1 due to neutropenia and diarrhea and 1 to pulmonary fibrosis. As of 12/06, 9 pts were too early to evaluate. Of the remaining 58 pts, there were 32 responses (55%; 95% CI: 42%, 68%), including 3 CRs and 29 PRs; Median PFS was 9.6 months (95% CI: 8.8, 13.9 months), 71% were progression-free for at least 8 months, and median OS was not reached after a median follow-up of 11.4 months (range 1.5–25.2 months). Conclusions: Treatment with mFOLFOX6+ B + C met the pre-specified criteria for objective response and PFS to be considered promising. This regimen is associated with an acceptable toxicity profile and merits further evaluation. Supported by N01-CA-62204. No significant financial relationships to disclose.
7
Nakai, Yousuke, Hiroyuki Isayama, Kazunaga Ishigaki, Naminatsu Takahara, Tsuyoshi Hamada, Suguru Mizuno, Hirofumi Kogure, et al. "Did multiagent chemotherapy improve clinical outcomes of advanced pancreatic cancer? A single center experience of 408 cases." Journal of Clinical Oncology 34, no. 4_suppl (February 1, 2016): 293. http://dx.doi.org/10.1200/jco.2016.34.4_suppl.293.
Full textAbstract:
293 Background: We previously reported the introduction of S-1 improved overall survival (OS) in advanced pancreatic cancer (PC), but in a pooled analysis of 3 RCTs, a combination of gemcitabine and S-1 (GS) improved OS in locally advanced PC (LAPC), but not in metastatic PC (MPC), compared to gemcitabine (Gem) alone. More recently, FOLFIRINOX, a multiagent chemotherapy, is shown to improve OS in MPC. We conducted clinical trials of a combination of Gem, S-1 and leucovorin (GSL) to further enhance antitumor effects. Herein, we retrospectively studied whether these multiagent regimens, GSL & FOLFIRINOX, affected the prognosis of APC, especially MPC. Methods: A total of 408 pts with APC receiving chemotherapy were grouped by treatment era into 3 groups: Group 1 (Years 2001-5: 53 pts prior to S-1 introduction), Group 2(Years 2005-11: 240 pts post S-1 introduction) and Group 3 (2012-14: 115 pts post multiagent treatment introduction), and clinical outcomes were compared. Results: Patient characteristics and protocol are shown in Table 1. Treatment protocol was single in 233, dual 142, and multiagent in 33. Response rate & disease control rate in Groups 1/2/3 were 2/8/17% & 26/67/73%. In LAPC, PFS was 6.2/8.9/7.9 & OS was 13.4/17.2/19.7 months in Groups 1/2/3. Meanwhile, in MPC, PFS was 2.0/3.5/4.8 & OS was 6.7/8.6/9.6 months in Groups 1/2/3. When treatment protocols were compared, in LAPC, PFS & OS were 7.0/11.7/8.8 & 13.6/22.6/22.6 months in singe/dual/multiagent chemotherapy. In MPC, PFS & OS were 3.1/3.5/6.0 & 8.3/8.1/13.7 months in single/dual/multiagent chemotherapy. Conclusions: While the introduction of S-1 led to longer OS in LAPC, recent introduction of multiagent chemotherapy appeared to improve OS in MPC. Whether multiagent chemotherapy would lead to longer OS than dual chemotherapy in LAPC needs further investigation. Table 1. [Table: see text]
8
Li, Wenyu, Ling Huang, Xinmiao Jiang, Xiaojuan Wei, Hanguo Guo, Liu Sichu, Chen Feili, and Zhanli Liang. "Clinical Characteristic and Survival Outcome of Peripheral T Cell Lymphoma in a Chinese Population." Blood 134, Supplement_1 (November 13, 2019): 5271. http://dx.doi.org/10.1182/blood-2019-129552.
Full textAbstract:
Background: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group comprising about 10-15% of non-Hodgkin lymphomas in Western populations. Only a minority (~30%) of patients with the most common PTCL subtypes achieve a durable remission and long-term survival. Data on the clinical features of PTCL in a Chinese population are limited. Methods: We retrospectively reviewed 342 patients with pathologically diagnosed T cell lymphoma at Guangdong Provincial People's Hospital from June 2007 through March 2019. We evaluated the incidence of PTCL subtypes, clinical characteristics and survival status. Results: Of the 342 patients, 17.3% (n=59) had PTCL-not otherwise specified(NOS), 9.4% (n=32) had angioimmunoblastic T-cell lymphoma(AITL), 19.6% (n=67) had anaplastic large cell lymphoma(ALCL) (anaplastic lymphoma kinase positive ALCL:12.0%, n=41; anaplastic lymphoma kinase negative ALCL: 9.6%, n=26), 36.2%(N=124) had NK/T cell lymphoma, 12.9% (n=44)had lymphoblastic lymphoma(LBL), and 4.6%(n=16) had other subtypes. For next data analysis, NK/T cell lymphoma and LBL were excluded. Finally, a total of 164 patients with integrally follow-up information were analyzed. The median age was 49.5 years (range 15-87) old and the median follow-up time was 15.8 months (range 0.5-124.3). Most patients were males (62.0%) with advanced stage disease (III/IV, 74.5%), and 51.0% of patients presented with B symptoms and 83.0% with no bulky disease. For the total population, the median progression-free survival(PFS) and overall survival(OS) was 6.5 months and 13.5 months, respectively. ALCL patients had better PFS and OS than PTCL-NOS and AITL (PFS: 51.2 vs. 5.8 vs.4.7 months, P = 0. 000; OS: not reached vs. 13.4 vs. 8.8 months, P = 0.000). There were no difference of PFS and OS between PTCL-NOS and AITL(P = 0. 550 and P = 0. 333, respectively). Conclusions: ALCL has better outcome than other PTCL subtypes. However, no efficacy therapy has emerged for patients with relapsed/refractory PTCL and outcomes in this setting are still poor. Novel potential targets for PTCL, with particular focus on identifying markers of response and resistance need further investigation. Disclosures Li: Guangdong Province Hospital: Employment.
9
Mason, Ginny, Musa Mayer, Sandra M. Swain, Peter Kaufman, Debu Tripathy, Sara A. Hurvitz, Joyce O'Shaughnessy, et al. "Experience and impact of alopecia in patients (pts) with HER2+ metastatic breast cancer (MBC) in the SystHERs registry." Journal of Clinical Oncology 35, no. 8_suppl (March 10, 2017): 239. http://dx.doi.org/10.1200/jco.2017.35.8_suppl.239.
Full textAbstract:
239 Background: Although alopecia is common with systemic chemotherapy, its psychological impact is often overlooked in treatment (tx) decisions. We sought to better understand the impact of alopecia using data from SystHERs, an observational registry of pts with HER2+ MBC. Methods: SystHERs enrolled pts ≥ 18 years within 6 mos of an MBC diagnosis. Pt-reported outcomes are assessed quarterly. The Alopecia Patient Assessment (APA, Genentech) is a validated instrument measuring the incidence of hair loss in the prior 3 mos and the impact of hair loss in the prior 7 days. The APA includes 5 items scored on a 5-point scale (total range: 1–25). Higher scores indicate greater impact. Pts completed the APA within 30–90 days of initial MBC tx. Subgroups with no hair loss, hair loss without impact, or impactful hair loss were compared descriptively. Results: As of June 3, 2016, 591 of 976 pts were eligible for this analysis. Of these, 175 (30%) reported no hair loss, 123 (21%) reported hair loss without impact, and 293 (50%) reported impactful hair loss within 30–90 days of initial MBC tx. Respectively, 23% (41/175), 82% (101/123), and 79% (231/293) were on active chemotherapy, most commonly docetaxel (39% [16/41], 66% [67/101], and 62% [144/231]) and paclitaxel (5% [2/41], 27% [27/101], and 23% [54/231]). Median time from initial chemotherapy tx to APA was 55, 70, and 64 days. Of all pts with no hair loss, 39% had de novo MBC vs 56% of pts with hair loss but no impact and 55% with impactful hair loss. Relative to the no-hair-loss and hair-loss-but-no-impact subgroups, the subgroup with impactful hair loss was younger (median 57 and 59 vs 54 years, respectively) and had more pts with ≥ 2 metastatic sites (51% and 54% vs 63%) and visceral metastases (59% and 63% vs 69%). The median total APA score for pts with impactful hair loss was 8.8 (IQR 7.0–12.5). Conclusions: Of pts reporting hair loss, 79–82% were receiving systemic chemotherapy. Pts with impactful hair loss may have had greater disease burden. Alopecia impacted self-image and embarrassment more than work or social functioning. Clinical trial information: NCT01615068. [Table: see text]
10
Gasparetto, Cristina, Brea Lipe, Sascha Tuchman, Nizar J. Bahlis, Heather J. Sutherland, Adriana C. Rossi, Suzanne Lentzsch, et al. "Selinexor containing regimens in patients with multiple myeloma (MM) previously treated with anti-CD38 monoclonal antibodies (αCD38 mAbs)." Journal of Clinical Oncology 39, no. 15_suppl (May 20, 2021): e20020-e20020. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e20020.
Full textAbstract:
e20020 Background: Exportin 1 (XPO1) mediates the nuclear export and functional inactivation of tumor suppressor proteins, is required for MM growth, is associated with poor prognosis in MM and mediates resistance to standard MM therapies. Selinexor (SEL) is a first-in-class, oral selective inhibitor of nuclear export (SINE) compound approved in combination with dexamethasone (dex) ± bortezomib for patients (pts) with previously treated MM. Once MM becomes refractory to αCD38 mAb, pts have limited effective treatment options and poor prognosis. Overall response rate (ORR) to the first regimen after refractoriness to an αCD38 mAb is 31%, median progression-free survival (mPFS) is 3.4 months (m), and median overall survival (mOS) is 8.6 m. The doublet SEL-dex (Xd) has shown ORR ̃26% in triple-class (IMID, PI, αCD38 mAb) refractory MM; SEL-based triplets could be more effective in this population. Methods: STOMP (Selinexor and Backbone Treatments of Multiple Myeloma Patients) is a multi-arm, open-label, Phase 1b/2 study evaluating SEL in various triplet combinations. Here, we retrospectively analyzed the efficacy and safety of SEL-containing triplets in pts previously treated with αCD38 mAbs. Pts received SEL-dex (Xd) plus pomalidomide (XPd, n = 19), bortezomib (XVd, n = 4), lenalidomide (XRd, n = 4), daratumumab (XDd, n = 2) or carfilzomib (XKd, n = 18). ORR, mOS, mPFS and adverse events (AEs) were analyzed. Results: Among the 47 pts, median age 64 yrs, female 53%, median time from diagnosis 5.1 yrs, median number of prior regimens 5 (range, 2–11). Prior daratumumab (96%), isatuximab (4%); 96% had MM refractory to aCD38 mAb, 81% had triple-class refractory MM, 74% and 47% were quad- and penta-exposed, 43% and 15% had quad- and penta-refractory MM. αCD38 mAb was included in the immediate prior regimen of 57% of pts and median duration from end of most recent aCD38 mAb therapy to first dose of study treatment was 6.9 weeks (range, 2.6-114.9). ORR was 51% among the 45 evaluable pts, 59% in the XPd arm (n = 17; 2 pts were not efficacy evaluable) and 67% in the XKd arm. ORR was 47% (9/19) among pts with quad-refractory MM and evaluable efficacy. Among all evaluable pts mPFS was 8.8 m (95% CI: 4.9, NE) and mOS was 20.4 m (95% CI: 9.6, NE). Among the 25 pts with αCD38 mAb in their immediate prior regimen, efficacy was similar to that regimen: ORR 52% vs. 45%, mPFS 8.8 vs. 9.3 m. The most common treatment emergent AEs were nausea (72%), anemia (64%), thrombocytopenia (60%), fatigue (57%), which were managed with standard supportive care and dose modifications. Conclusions: SEL-containing triplets in pts with MM previously treated with αCD38 mAbs, most of whom had triple-class refractory MM, exhibit tolerability and comparable effectiveness to their most recent αCD38 mAb-containing regimens. Compared to historical control, mOS was much higher among these patients. Further investigation is warranted. Clinical trial information: NCT02343042.
Books on the topic "828.996 67"
1
Innovación Docente y Calidad Institucional : Jornadas de Innovación Docente e Investigación Educativa UZ, Zaragoza, 5 y 6 de septiembre de 2019. Universidad de Zaragoza, 2021. http://dx.doi.org/10.26754/uz.978-84-09-29715-3.
Full textAbstract:
Índice de Contenidos Aplicación de metodologías activas I 9 Estrategias de gamificación, y aprendizaje entre pares, para la adquisición de competencias 13 Herramientas para la gestión de los recursos digitales en los procesos de enseñanza-aprendizaje 28 Gamificación de la Cristalografía mediante la App XtereO 40 Educación Visual y Plástica comprometida con el entorno próximo 49 Experiencias de coordinación entre el profesorado 67 Diseño de actividades multidisciplinares de Ciencias de la Naturaleza y Matemáticas 71 Evaluación del aprendizaje 99 Impacto del Concurso de Cristalización en la Escuela en Aragón en el profesorado participante. 103 ¿Influye el género en la evaluación entre iguales? 113 Acciones de integración y orientación de estudiantes 133 Competencias digitales para estudiantes de la Universidad de Zaragoza 158 La organización emocional del aula en la gestión de la actividad docente 164 La motivación como herramienta para mejorar la tasa de aprobados en la asignatura de Contabilidad Financiera II. 20 Gamificación a través de diferentes aplicaciones como innovación docente en el grado de Ciencias de la Actividad Física y del Deporte 33 Utilización de vídeos y cuestionarios para la mejora del proceso de enseñanza-aprendizaje de conocimientos requeridos en la asignatura “Criterios de diseño de máquinas” 58 Acercando a los estudiantes de magisterio una experiencia colaborativa realizada en Educación Primaria 78 La formación de los futuros maestros desde un modelo interdisciplinar para las enseñanzas de Lengua Castellana y LIJ. 88 Evaluación de necesidades y seguimiento del aprendizaje en competencias de comunicación académica en inglés a través de un focus group en ADEi 121 Percepción de los estudiantes de los grados de la Facultad de Economía y Empresa sobre el uso y utilidad de las tutorías 137 Integración de los estudiantes de ADE en el mercado laboral a través del programa de prácticas y actividades externas. 148 Promoviendo la reflexión entre docentes acerca delas bases fundamentales sobre las que construirla ciudadanía digital 171 Estudio de opinión de los alumnos del Grado en Medicina sobre las limitaciones éticas de la ciencia 179 Percepción social de la ciencia por los alumnos del Grado en Medicina 185 La dirección de Trabajos Fin de Grado (TFG) en el marco de las nuevas modalidades de educación universitaria a distancia: algunas claves metodológicas para su adecuada ejecución 191 Experiencia piloto para mejorar las competencias de trabajo en equipo y comunicación oral en asignaturas de ingeniería 198 Otras metodologías activas II. 207 Metodologías activas basadas en juegos de razonamiento para fomentar el aprendizaje 211 El dispositivo móvil en el aula, ¿herramienta educativa o distracción? 217 Mejora de la adquisición de competencias a través del modelo de aula inversa 224 El customer journey map en la formación de la empatía y la innovación 232 La gamificación en el aula para la mejora de la participación del alumno en el estudio de la asignatura de Esplacnología. 239 Los cuestionarios Moodle como una herramienta para mejorar la calidad de la docencia y fomentar el aprendizaje en el aula universitaria 246 Un canal de YouTube como mecanismo de adquisición de competencias transversales 251 Arte y reciclaje en los entornos educativos (Trash art) 260 Didáctica con la gamificación y el videojuego mediante una intervención multidisciplinar para estudiantes del Grado de Maestro 270 YouTube como repositorio de vídeos docentes de apoyo a la docencia 278 Aplicación de Metodologías Activas III 287 Combinación de la Técnica Just in Time Teaching y los Serious Games con el enfoque pedagógico Flipped Learning en Educación Superior 291 Aprendizaje de lenguas para la inclusión social 303 Gamificación y role playing en la enseñanza de Derecho Procesal Penal, intervención de la Persona Jurídica y cumplimiento normativo 310 Integrando diferentes aplicaciones TIC en la docencia universitaria: uso de Screencast-o-matic, Canva y Pocket 317 Evaluación del uso de diferentes TIC en la docencia universitaria: grupo MultiFlipTech 323 Experiencias de mejora de la calidad de las titulaciones 335 Coordinación de agentes y mejora de los instrumentos de evaluación de las prácticas escolares: selección de las dimensiones a calificar 339 Enseñanza a distancia en el grado en Gestión y Administración Pública 345 Selección y rendimiento de los estudiantes en la asignatura Organización y Gestión Interna 356
Conference papers on the topic "828.996 67"
1
Correia, Carlos Anderson Gomes, and Francisca Aglaiza Romão Sedrim Gonçalves. "PEQUENO ESTUDO SOBRE A DIFICULDADE DE ALUNOS DO 1º ANO DO ENSINO MÉDIO NAS OPERAÇÕES BÁSICAS DA MATEMÁTICA." In I Congresso Brasileiro de Educação a Distância On-line. Revista Multidisciplinar de Educação e Meio Ambiente, 2021. http://dx.doi.org/10.51189/rema/857.
Full textAbstract:
Introdução: Este é um estudo realizado em quatro turmas de 1º Ano do Ensino Médio Integral da Escola AB. Objetivo: Identificar o nível de dificuldade de alunos iniciantes do Ensino Médio nas Operações Básicas da Matemática. Material e métodos: Foi enviado, de forma remota através de redes sociais, um exercício para as turmas na primeira semana de aula, contendo duas contas de soma, duas de subtração e duas de multiplicação. Resultados: As quatro turmas juntas possuem 205 alunos no total, onde 99 destes alunos enviaram a resolução do exercício, o que representa 48,3% do total, sendo 67 mulheres (67,68% dos que enviaram) e 32 homens (32,32% dos que enviaram). 82 alunos acertaram todas as contas, 4 erraram as duas contas de subtração, 1 errou a subtração de números com dois dígitos, 4 erraram a subtração de números com 3 dígitos. 1 aluno errou as duas contas de soma, 3 erraram a soma de números com dois dígitos, 2 erraram a soma de números com três dígitos. 3 alunos erraram uma das multiplicações com um número de dois dígitos e 1 número com um dígito. Em relação à participação, 80 alunos enviaram a resolução no mesmo dia, outros 14 enviaram no decorrer da mesma semana, 5 enviaram na semana seguinte. Conclusão: 82% acertaram todas as contas, onde podemos levar em consideração o possível contato entre alunos e o uso de tecnologias, porém, alguns alunos ainda mostraram dificuldades, principalmente nas contas de subtração com dois e com três dígitos, mais precisamente, 9 alunos.
2
Lohri, A., B. Huser, B. Lämmle, M. Oberholzer, G. Thiel, and F. Duckert. "FACTOR XII, PLASMA PREKALLIKREIN ,α2-MACROGLOBULIN AND C1-INHIBITOR LEVELS IN RENAL ALLOGRAFT RECIPIENTS DURING IMMUNOSUPPRESSION WITH CYCLOSPORIN A." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644122.
Full textAbstract:
Factor XII clotting activity (FXII), Plasma Pre-kallikrein amidolytic activity (PK), 2-Macroglobulin ( α2-M) and cT-Inhibitor (cT-Inh) antigen have been measured in 17 patients immediately before and sequentially up to four months after kidney transplantation. Based on suspected Cyclosporin A (CyA) induced endothelial damage, activation of the contact system with resulting consumption of the contact activation factors was^evaluated. Before transplantation, FXII, PK, α2-M, Cl-Inh levels were 99±27%, 102±21%, 115±55%, and 129±32%, respectively. In the first two weeks after transplantation FXII decreased to 65±27%, PK to 67±20% and α2-M to 88±42%; Cl-Inh rose to a maximum of 201±44% (mean ± S. D.)(2p<0.001). Mean FXII levels correlated positively with PK, α2-M and albumin and negatively with CyA level and dose and serum bilirubin. PK and α2-M correlated positively with each other and with albumin and negatively with creatinine, bilirubin and CyA (p<0.01). The changes of FXII, PK and α2-M after transplantation suggest an influence of CyA on production or consumption of these factors. The behaviour of the cT-Inh may be unspecific and related to its action of an acute phase reactant.
3
Malte, P. C., S. Bernstein, F. Bahlmann, and J. Doelman. "NOx Exhaust Emissions for Gas-Fired Turbine Engines." In ASME 1990 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1990. http://dx.doi.org/10.1115/90-gt-392.
Full textAbstract:
A database consisting of 18 heavy-duty and aeroderivative gas turbine engine models, fired on natural gas, is evaluated for NOx exhaust emissions with and without water and steam injection. CO exhaust emissions are also considered. Engine baseload power outputs range from 2.9 to 83.5 MW, compressor pressure ratios are from 7.2 to 30.0, and turbine inlet temperatures are from 1150 to 1515K. The engine models are from the late 1970s to the current period, and all use diffusion flame combustors. Baseload, uncontrolled NOx exhaust emissions, corrected to 15% O2 dry conditions, vary from 67 to 240 ppmv. CO exhaust emissions vary from 7 to 96 ppmv. Except for three low-NOx aero-derivative engines, the uncontrolled NOx exhaust emissions scale with engine pressure ratio and fuel-air ratio. A correlation formula is developed, and discussed relative to formulas in the literature. NOx control by water injection shows a fairly wide band; at a water-to-fuel mass ratio of 0.8, the NOx reduction varies from 58 to 82 percent. Engines with the highest uncontrolled NOx show the largest percentage reduction by water injection. On the other hand, NOx control response with steam injection exhibits less variation across the engine models. The relation of CO to NOx levels and and the response of CO to water and steam injection are examined, though quantitative correlations are not made.