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Relevant bibliographies by topics / 9 acridinyl amino acid derivatives

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Academic literature on the topic '9 acridinyl amino acid derivatives'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "9 acridinyl amino acid derivatives"

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Rupar, Jelena, Vladimir Dobričić, Jelena Grahovac, et al. "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives." RSC Med Chem 11, no. 3 (2020): 378–86. https://doi.org/10.1039/c9md00597h.

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A series of eleven 9-acridinyl amino acid derivatives were synthesized using a two-step procedure. Cytotoxicity was tested on the K562 and A549 cancer cell lines and normal diploid cell line MRC5 using the MTT assay. Compounds 6, 7, 8 and 9 were the most active, with IC50 values comparable to or lower than that of chemotherapeutic agent amsacrine. 8 and 9 were especially effective in the A549 cell line (IC50 ≈ 6 μM), which is of special interest since amsacrine is not sufficiently active in lung cancer patients. Cell cycle analysis revealed that 7 and 9 caused G2/M block, amsacrine ca

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Zlatković, Đorđe, Vladimir Dobričić, Jelena Srbljanović, et al. "N-(9-Acridinyl) Amino Acid Derivatives: Synthesis and In Vitro Evaluation of Anti-Toxoplasma gondii Activity." Pharmaceutics 17, no. 3 (2025): 374. https://doi.org/10.3390/pharmaceutics17030374.

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Background/Objectives: Acridine, an aromatic heterocyclic compound, serves as a basis for the synthesis of potent bioactive derivatives, displaying a broad spectrum of biological activity, such as antibacterial, antitumor, and antiparasitic activity. With the ability to undergo various types of electrophilic substitutions, introducing different side chains could lead to compounds being active towards various and potentially multiple biotargets. Toxoplasma gondii, a ubiquitous protozoan parasite with worldwide distribution, poses a major health threat, particularly in immunocompromised patients

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Rupar, Jelena, Vladimir Dobričić, Jelena Grahovac, et al. "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives." RSC Medicinal Chemistry 11, no. 3 (2020): 378–86. http://dx.doi.org/10.1039/c9md00597h.

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4

Chiu, FCK, RTC Brownlee та DR Phillips. "Cupric Ion Chelation Assisted Synthesis of N(α)-Protected N(ω)-Acridin-9-yl α,ω-Diamino Carboxylic Acids". Australian Journal of Chemistry 46, № 8 (1993): 1207. http://dx.doi.org/10.1071/ch9931207.

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The synthesis of Nα-protected Nω-acridin-9-yl derivatives of the α,w-diamino carboxylic acids ornithine and lysine is reported. Direct introduction of the acridin-9-yl moiety to the amino side chain of the free amino acid was achieved in methanol through temporary copper(II) chelation protection of the α-amino and carboxy groups. Nα-Fmoc protection was introduced by using N-(fluoren-9-ylmethoxycarbonyloxy)succinimide in aqueous dioxan.

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5

Janovec, Ladislav, Gejza Suchár, Ján Imrich, et al. "9-Isothiocyanatoanthracene as a Versatile Starting Compound in the Chemistry of Anthracen-9-yl Derivatives." Collection of Czechoslovak Chemical Communications 67, no. 5 (2002): 665–78. http://dx.doi.org/10.1135/cccc20020665.

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The synthesis, structure and reactivity of 9-isothiocyanatoanthracene (5) likewise the conformation of the corresponding thioureas (6a-6i) have been studied. The 13C NMR substituent chemical shift values of the NCS group and correlations between spectral parameters (IR, NMR) and rate constans of reactions of 5, acridin-9-yl (14), phenyl (15) and benzoyl isothiocyanate (16) with butylamine were found. Significant increase of the fluorescence of the synthesized anthracenylthioureas with amino acid rests refers to the possibility to use 5 as potential biomarker.

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Smetanin, Nikolay, Sofia Tokarieva, Svetlana Varenichenko, Oleg Farat, and Victor Markov. "IN SILICO PREDICTION AND MOLECULAR DOCKING STUDIES OF BIOLOGICAL ACTIVITY OF HYDROACRIDINE (QUINOLINE) DERIVATIVES." Ukrainian Chemistry Journal 87, no. 5 (2021): 38–52. http://dx.doi.org/10.33609/2708-129x.87.05.2021.38-52.

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To find biological activity among easily available 2-[(4S,4’S/4R,4’R)-2’,5’-dioxo-2,3,5,6,7,8-hexahydro-1H-spiro[acridine-4,3’-pyrrolidin]-4’-yl]-N-aryl-acetamide, (4S/4R)-4-[(3R/3S)-1-(2-aryl)-2,5-dioxopyrrolidin-3-yl]-1,2,3,4,5,6,7,8-octahydroacridine-4-carbonitrile, (3S/4R)-3-[(3R/4S)-9-chloroacridine(quinoline)-4-yl]-1-N-aryl)pyrrolidine-2,5-diones. Methods: Organic synthesis, spectral methods, and molecular docking. We investigated by molecular docking the potential biological activity of previously synthesized compounds containing acridine and pyrrolidine-2,5-diones fragments in their st

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7

Matarazzo, Augusto, Mohamed E. Moustafa, and Robert H. E. Hudson. "5-(Acridin-9-ylamino)uracil — A hydrolytically labile nucleobase modification in peptide nucleic acid." Canadian Journal of Chemistry 91, no. 12 (2013): 1202–6. http://dx.doi.org/10.1139/cjc-2013-0288.

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5-Aminouracil (5-AU) is a readily available yet underutilized starting material for the synthesis of labelled nucleobase analogues. We have prepared the derivative of 5-AU with the amine-reactive chromophore 9-chloroacridine for the purpose of investigating its potential as a base-discriminating fluorophore. 9-Chloroacridine readily undergoes substitution by reaction with 5-AU to yield a fluorescent nucleobase that after standard manipulations produced a monomer suitable for incorporation into peptide nucleic acid (PNA) by fluorenylmethyloxycarbonyl (Fmoc)-based oligomerization chemistry. Alth

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8

Kimura, Michio. "Acridine Derivatives. I. Molecular Structure of the Novel Acridinyl-Substituted Uracil, 5-(9-Acridinyl)-6-amino-1,3-dimethyluracil." Bulletin of the Chemical Society of Japan 60, no. 2 (1987): 447–51. http://dx.doi.org/10.1246/bcsj.60.447.

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RAGAB, A. EL-SAYED. "Some Novel Organosulfur Amino Acid Derivatives." Journal of Indian Chemical Society Vol. 75, May 1998 (1998): 323–24. https://doi.org/10.5281/zenodo.5945267.

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Chemistry Department. Faculty of Science, Al-Azhar University, Nasr City,Cairo, Egypt <em>Manuscript received 14 February 1997, accepted 8 September 1997</em> Synthesis of a series of 4-chlorocinnamanilide-4'-sulfonylamino acids (2-8), and some of the corresponding amino acid methyl esters (9-13) and hydrazides (14-16) are described. Coupling reactions of 4-chlorocinnamanilidc-4'-sulfonylamino acids with amino acid methyl ester hydrochloride in <strong>THF-Et<sub>3</sub>N</strong> medium using dicyclohexylcarbidiimide method give the dipeptide methyl esters (17-19).

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Moustafa, Moustafa Sherief, Saleh Mohammed Al-Mousawi, Maghraby Ali Selim, Ahmed Mohamed Mosallam, and Mohamed Hilmy Elnagdi. "Organobase-catalyzed three-component reactions for the synthesis of 4H-2-aminopyrans, condensed pyrans and polysubstituted benzenes." Beilstein Journal of Organic Chemistry 10 (January 14, 2014): 141–49. http://dx.doi.org/10.3762/bjoc.10.11.

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Novel routes for the preparation of 2-amino-4H-pyran-3-carbonitrile 9, amino-arylbenzoic acid ester derivatives 13a,b, 2-aminotetrahydro-4H-chromene-3-carbonitrile 18, 3-amino-4-cyanotetrahydronaphthalene-2-carboxylic acid ester 26 and 4-amino-3,5-dicyanophthalic acid ester derivatives 37a–c were developed. The synthetic methods utilize one-pot reactions of acetylene carboxylic acid esters, α,β-unsaturated nitriles and/or active methylenenitriles in the presence of L-proline or DABCO. Plausible mechanisms are suggested for the formation of the products. Finally, these compounds were used for t

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Book chapters on the topic "9 acridinyl amino acid derivatives"

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Gera, Lajos, Daniel C. Chan, Vitalija Simkeviciene, Paul A. Jr Bunn, and John M. Stewart. "N-(Fluorenyl-9-methoxycarbonyl)amino Acid Amide Derivatives as a New Class of Anti-cancer Agents." In Advances in Experimental Medicine and Biology. Springer New York, 2009. http://dx.doi.org/10.1007/978-0-387-73657-0_200.

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Deming, T. J. "Amino Acid Derivatives, Polymerization of." In Encyclopedia of Materials: Science and Technology. Elsevier, 2001. http://dx.doi.org/10.1016/b0-08-043152-6/00030-9.

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Kanayama, Takatoshi, Kazumasa Yoshida, Hideto Miyabe, and Yoshiji Takemoto. "Enantio- and Diastereoselective Ir-Catalyzed Allylic Substitutions for Asymmetric Synthesis of β-Substituted α-Amino Acid Derivatives." In 19th International Congress on Heterocyclic Chemistry. Elsevier, 2003. http://dx.doi.org/10.1016/b978-0-08-044304-1.50326-9.

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Lambert, Tristan H. "Functional Group Protection." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0012.

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An efficient method for allylation of a sterically hindered alcohol in the presence of base-sensitive functionality (cf. 1 to 2) has been developed (Tetrahedron Lett. 2012, 53, 1319) by Richard B. Silverman at Northwestern University. Mark S. Taylor at the University of Toronto found (J. Am. Chem. Soc. 2012, 134, 8260) that borinic acid 4 catalyzed the monofunctionalization of diols and carbohydrates such as 3. The selective functionalization of unprotected peptides can be challenging, but Man-Kin Wong at Hong Kong Polytechnic University and Chi-Ming Che at the University of Hong Kong have sho

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Taber, Douglass. "New Methods for the Stereoselective Construction of N-Containing Rings." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0053.

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Several methods have been reported for the stereocontrolled preparation of pyrrolidine and piperidine derivatives. Alison J. Frontier of the University of Rochester has observed (Organic Lett. 2007, 9, 4939) that hydrogenation of acyl pyrroles such as 1 gave good control not just around the ring, but also on the sidechain. Chi-Ming Che of the University of Hong Kong has devised ( J. Am. Chem. Soc. 2007, 129, 5828) a catalyst that converted amides such as 3 into the cyclized product 4, also with high diastereocontrol. Jean Ollivier of the Université de Paris-Sud, following the Sato procedure, h

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Taber, Douglass F. "Reactions of Alkenes." In Organic Synthesis. Oxford University Press, 2015. http://dx.doi.org/10.1093/oso/9780190200794.003.0030.

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Fung-E Hong of the National Chung Hsing University devised (Adv. Synth. Catal. 2011, 353, 1491) a protocol for the oxidative cleavage of an alkene 1 (or an alkyne) to the carboxylic acid 2. Patrick H. Dussault of the University of Nebraska found (Synthesis 2011, 3475) that Na triacetoxyborohydride reduced the methoxy hydroperoxide from the ozonolysis of 3 to the aldehyde 4. Reductive amination of 4 can be effected in the same pot with the same reagent. Philippe Renaud of the University of Bern used (J. Am. Chem. Soc. 2011, 133, 5913) air to promote the free radical reduction to 6 of the interm

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Taber, Douglass. "Alkaloid Synthesis: Paliurine F, Lepadiformine, and 7-Deoxypancratistatin." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0057.

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The sedative alkaloid paliurine F 7 is a pentapeptide bridged by an arene. Gwilherm Evano of the Université de Versailles took advantage of this in his synthesis (Angew. Chem. Int. Ed. 2007, 46, 572) of 7, although it was necessary to prepare, from serine, one of the amino acid derivatives, the protected 3-hydroxyprolinol 2. The key step in the synthesis was the Cu-catalyzed intramolecular coupling of 5 to give the macrolactam 6. Deprotection and acylation then gave paliurine F 7. Lepadiformine 14, isolated from the tunicate Clavelina lepadiformis, shows moderate cytotoxicity, and is also a K+

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Conference papers on the topic "9 acridinyl amino acid derivatives"

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Hijikata-Okunomiya, A., S. Okamoto, R. Kikumoto, and Y. Tamao. "STEREOGEOMETRY OP THE ACTIVE SITES OF SERINE ENZYMES GATHERED FROM SYNTHETIC THROMBIN-INHIBITORS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644606.

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MD-805 is a potent thrombin-inhibitor having the structure of tri-pods; Arg skeletone, N-terminal side and C-terminal side. MD-805 showed weaker inhibitory activity to other enzymes than thrombin. In this report, to gather more detailed informations about the structural features of serine enzymes concerning the specificity, we experimentally examined the structure-activity relationship (SAR) of a number of arginine derivatives including MD-805 and theoretically generated a MD-805-trypsin complex model using the results of X-ray crystallography of MD-805 and BPTI-trypsin complex by calculation

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