Log in

Relevant bibliographies by topics / 9-dione / Journal articles

To see the other types of publications on this topic, follow the link: 9-dione.

Journal articles on the topic '9-dione'

Author: Grafiati

Published: 5 June 2025

Last updated: 25 June 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic '9-dione.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Farkens, Michael, Ion Neda та Reinhard Schmutzler. "Zur Chemie der 1,3,5-Triaza-2-phosphorinan-4,6-dione. Teil VIII. Weitere 1,3,5-Triaza-2 λ3-und 1,3,5-Triaza-2 λ4-phosphorinan-4,6-dione mit (2-Chlorethyl)amino-und Bis(2-chlorethyl)amino-Substituenten / Chemistry of the 1,3,5-Triaza-2-phosphorinan-4,6-diones. Part VIII. Further 1,3,5-Triaza-2λ3- and 1,3,5-Triaza-2λ4-phosphorinane-4,6-diones with (2-Chloroethyl)amino- and Bis(2-chloroethyl)amino Substituents". Zeitschrift für Naturforschung B 49, № 4 (1994): 445–50. http://dx.doi.org/10.1515/znb-1994-0403.

Full text

Abstract:

In the reaction of 2-chloro-1,5-dimethyl-3-phenyl-1,3,5-triaza-2λ3-phosphorinane-4,6- dione (1) and 2-chloro-1,3,5-triphenyl-1,3,5-triaza-2λ3-phosphorinane-4,6-dione (2) with (2-chloroethyl)amine hydrochloride or bis(2-chloroethyl)amine hydrochloride in the presence of triethylamine the corresponding (2-chloroethyl)amino- and bis(2-chloroethyl)amino-substituted 2λ3-phosphorinane-4,6-diones (3-6) are formed. Oxidation with the hydrogen peroxide- urea-1: 1-adduct gives the corresponding 2-oxo-2λ4-phosphorinane-4,6-diones (7-10), in the same manner as described in the literature for the 1,3,5-trimethyl-1,3,5-triaza-2λ4-phosphorinane- 4,6-diones [6]. Hydrolysis of 1 leads to 2-hydro-1,5-dimethyl-3-phenyl-1,3,5-triaza- 2λ4-phosphorinane-4,6-dione (11). Compounds 3 -11 have been characterized via their 1H, 13C and 31P NMR spectra, mass spectra, and, with the exception of 9, through elemental analyses.

APA, Harvard, Vancouver, ISO, and other styles

2

Aesha F SH Abdassalam, Aesha F. SH Abdassalam, Semih Kurban Semih Kurban, and Nahide Gulsah Deniz and Cigdem Sayil Nahide Gulsah Deniz and Cigdem Sayil. "Synthesis and Characterization of New Naphtho- and Tetracyclic Diazaquinone Derivatives." Journal of the chemical society of pakistan 41, no. 5 (2019): 834. http://dx.doi.org/10.52568/000805/jcsp/41.05.2019.

Full text

Abstract:

In this study, new 1,4-naphtho- and 5-nitro-1,4-naphtho derivatives containing N- and N,N-substituted groups which has not been reported yet, have been synthesized from 2,3-dichloronaphthalene-1,4-diones (1,9). Compounds of 2-choloro-3-((2,4,6-triflorophenyl)amino)naphthalene-1,4-dione (3) and 2-chloro-3-((4-florophenyl)amino)naphtalene-1,4-dione (7) were obtained by reactions of 2,3-dichloronaphthalene-1,4-dione 1 with 4-fluoroaniline (6) and 2,4,6-trifloroaniline (2), respectively involving a Michael addition. We reported the cyclization reactions of compounds 1 to benzo[g]pirido[3,2-b]quinoxaline-6,11(5H,12H)-dione (5) synthesized. The N-substituted naphthoquinone 7 was reacted with sodium azide in dimethylformamide and 2-florobenzo[b]phenazin-6,11-dione (8) was obtained as the one cyclized compound. Regioisomers 3-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-chloro-5-nitronaphthalene-1,4-dione 11 and 2-(4-(benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-3-chloro-5-nitronaphthalene-1,4-dione 12 were obtained from reaction of 2,3-dichloro-5-nitronaphthalene-1,4-dione 9 with 1-piperonylpiperazine (10).

APA, Harvard, Vancouver, ISO, and other styles

3

Rádl, Stanislav. "Preparation of 1-Hydroxyxanthen-9(9H)-ones and 1-Hydroxyacridin-9(10H)-ones via Corresponding 3,4-Dihydro-1,9(2H)-diones." Collection of Czechoslovak Chemical Communications 60, no. 12 (1995): 2127–36. http://dx.doi.org/10.1135/cccc19952127.

Full text

Abstract:

Target 10-cyclopropyl-7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)acridin-9(10H)-one (IVc) and 7-fluoro-1-hydroxy-6-(4-methyl-1-piperazinyl)-9H-xanthen-9-one (IVd) were obtained from corresponding difluoro derivatives IVa and IVb, respectively. These intermediates were synthesized via respective 3,4-dihydro-1,9(2H)-diones Va and Vb. Acridine derivative (10-cyclopropyl-6,7-difluoro-3,4-dihydro-1H-acridine-1,9(2H,10H)-dione, Va) was synthesized from 1-cyclopropyl-6,7-difluoroisatoic anhydride (XI) and xanthene derivative (6,7-difluoro-3,4-dihydro-1H-xanthen-1,9(2H)-dione, Vb) from cyclohexenone derivative VIb. Several unsuccessful attempts to prepare hydroxyacridone IVc and/or some useful intermediates of its synthesis are also described.

APA, Harvard, Vancouver, ISO, and other styles

4

Journal, Baghdad Science. "Synthesis & Characterization of Oxazinan and 5-oxa-7-aza-spiro[2,5] octane from reaction of Dibenzylidene with malonic anhydride and 5-oxa-spiro[2,3] hexane-4,6-dione." Baghdad Science Journal 4, no. 2 (2007): 276–84. http://dx.doi.org/10.21123/bsj.4.2.276-284.

Full text

Abstract:

Di Benzylidenes were prepared by condensation of 1,2-diamino benzene with o- hydroxy benzaldehyde. These dibenzylidenes when treated with one equivalent of malonic anhydride or 5-oxo-spiro[2,3]hexane-4,6-dione in dry benzene give 6-membered heterocyclic ring system of 3-{2-[(2-Hydroxy-benzylidene)-amino]-phenyl}-2-(2-hydroxy –phenyl)-[1,3]oxazinane-4,6-diones ( 1-3) or 7-{2-[(2-hydroxy-benzylidene)-amino]-phenyl}-6-(2-hydroxy-phenyl)-5-oxa-7-aza-spiro[2.5]octane-4,8-diones ( 7- 9 ) But when two equivalents of malonic anhydride or 5-oxo-spiro[2,3]hexane-4,6-dione were used and under sam conditions compounds (4-6 , 10-12 ) were obtained .

APA, Harvard, Vancouver, ISO, and other styles

5

Šimo, Ondrej, Alfonz Rybár, and Juraj Alföldi. "Synthesis of 4-Alkyl- or 4-Phenyl-7-methyl-1,2-dihydro-7H-imidazo[1,2,3-cd]purine-6,8-diones." Collection of Czechoslovak Chemical Communications 63, no. 3 (1998): 407–15. http://dx.doi.org/10.1135/cccc19980407.

Full text

Abstract:

New 4-alkyl- or 4-phenyl-7-methyl-1,2-dihydro-7H-imidazo[1,2,3-cd]purine-6,8-diones 1 were obtained by intramolecular alkylation of 8-alkyl- or 8-phenyl-9-(2-mesyloxyethyl)-1-methyl-9H-purine-2,6(1H,3H)-diones 5. The necessary compounds 5 were prepared from 6-[(2-hydroxyethyl)- amino]-3-methyl-5-nitrosopyrimidine-2,4(1H,3H)-dione (2), which was hydrogenated to 5-amino-6-[(2-hydroxyethyl)amino]-3-methyl derivative 3; consecutive reactions of the latter with an orthocarboxylate and mesyl chloride afforded 8-alkyl- or 8-phenyl-9-(2-hydroxyethyl)-1-methyl-9H-purine- 2,6(1H,3H)-diones 4 and compounds 5, respectively.

APA, Harvard, Vancouver, ISO, and other styles

6

Hemakumar, K. H., A. D. Sathisha, and Y. B. Basavaraju. "Synthesis and Characterization of New Diketone Analogues of Podophyllotoxin." E-Journal of Chemistry 5, no. 1 (2008): 114–19. http://dx.doi.org/10.1155/2008/314724.

Full text

Abstract:

The new compounds 6,6a-dihydro-2,3-dimethoxy-9-nitro–11bH benzo [C]-fluoren 5,7-dione, 6,6a-dihydro-2,3-dimethoxy-9-chloro–11bH benzo[C]-fluoren-5,7-dione and 6,6a-dihydro-2,3-dimethoxy-9-fluoro–11bH benzo[C]-fluoren-5,7- dione were synthesized in high yields. They are analogues of naturally occurring lignan podophyllotoxin which exhibits anticancer activity. They are very essential to study anticancer activity.

APA, Harvard, Vancouver, ISO, and other styles

7

Jin, Shangde, and Jürgen Liebscher. "Novel Tandem Cyclisations at the Piperazinedione Ring via Cope Rearrangement." Zeitschrift für Naturforschung B 57, no. 4 (2002): 377–82. http://dx.doi.org/10.1515/znb-2002-0403.

Full text

Abstract:

Novel rearrangements of 3-ylidene-piperazine-2,5-dione (1) were achieved affording Cope rearrangement products 3 and 4 under neutral conditions or tricyclic piperazine-2,5-diones 5, rac-6 and 7 by additional tandem cyclisation in formic acid. Cope rearrangement products 3 and 4 were transformed into new quaternary α-amino acids 9 and 11 by hydrogenation and hydrolysis.

APA, Harvard, Vancouver, ISO, and other styles

8

Owotoki, Wamuyu, Detlef Geffken, and Thomas Kurz. "Synthesis of 1-Hydroxypyrrolidin-2,5-dione Derivatives of the Phosphonic - Hydroxamic Acid Antibiotic SF-2312." Australian Journal of Chemistry 59, no. 4 (2006): 283. http://dx.doi.org/10.1071/ch06058.

Full text

Abstract:

Analogues of the antibiotic SF-2312 with a 3-substituted 1-hydroxypyrrolidine moiety have been prepared from 1-benzyloxy-3-bromopyrrolidin-2,5-dione (1) through Michaelis–Arbusov reaction with various trialkyl phosphites and subsequent alkylation of ring position 3. Cleavage of phosphonic esters 3 by TMSBr afforded the corresponding phosphonic acids 7, which were treated with ethanolamine to give the monosalts 8. Finally, hydrogenolysis furnished 1-hydroxypyrrolidin-2,5-diones 9.

APA, Harvard, Vancouver, ISO, and other styles

9

Baker, L. J., G. R. Clark, B. R. Copp, R. P. Hansen, and C. J. Squire. "2-Ethylthio-9-methyl-1,4-dihydroacridine-1,4-dione and 9-methyl-2-(4-tolylthio)-1,4-dihydroacridine-1,4-dione." Acta Crystallographica Section C Crystal Structure Communications 55, no. 4 (1999): 634–36. http://dx.doi.org/10.1107/s0108270198014929.

Full text

APA, Harvard, Vancouver, ISO, and other styles

10

Choudhary, Muhammad Iqbal, Muhammad Nasir, Shamsun N. Khan та ін. "Microbial Hydroxylation of Hydroxyprogesterones and α-Glucosidase Inhibition Activity of Their Metabolites". Zeitschrift für Naturforschung B 62, № 4 (2007): 593–99. http://dx.doi.org/10.1515/znb-2007-0419.

Full text

Abstract:

Microbial transformation of 11α-hydroxyprogesterone (1) with Cunninghamella elegans, Gibberella fujikuroi, Fusarium lini, and Candida albicans yielded 11α,15α,16α-trihydroxypregn-4- ene-3,20-dione (3), 11α-hydroxy-5α-pregnane-3,20-dione (4), 6β ,11α-dihydroxypregn-4-ene-3,20- dione (5), 11α-hydroxypregna-1,4-diene-3,20-dione (6), 11α,17β -dihydroxyandrost-4-en-3-one (7), and 11α,15α-dihydroxypregn-4-ene-3,20-dione (8). On the other hand, microbial transformation of 17α-hydroxyprogesterone (2) with Cunninghamella elegans and Fusarium lini yielded 11α,17α- dihydroxypregn-4-ene-3,20-dione (9), and 17α-hydroxypregna-1,4-diene-3,20-dione (10). The structures of the metabolites 3 - 10 were deduced on the basis of spectroscopic methods. Compound 3 was identified as a new metabolite, which exhibited a promising inhibitory activity against the α-glucosidase enzyme.

APA, Harvard, Vancouver, ISO, and other styles

11

Brown, RFC, KJ Coulston, FW Eastwood, and S. Saminathan. "Detection of the 1,2-Didehydronaphthalene to 1H-Indenylidenecarbene Rearrangement by Intramolecular Trapping in a Flash Vacuum Pyrolytic Reaction." Australian Journal of Chemistry 40, no. 1 (1987): 107. http://dx.doi.org/10.1071/ch9870107.

Full text

Abstract:

Flash vacuum pyrolysis of 9-methyl-1,3-dihydronaphtho[1,2-c]furan-1,3-dione (8) at 750-880� gave exclusively 1H-cyclopent[ cd ]indene (9) and of 8-methyl-1,2-dihydrocyclobuta[a]naphthalene-1.2-dione (10) at 600-840� gave a mixture of (9) and acenaphthylene. Acenaphthylen-4-ol (12) was synthesized and found to be stable to flash vacuum pyrolysis over thetemperature range 600-900�. These findings are discussed in relation to the rearrangement described in the title.

APA, Harvard, Vancouver, ISO, and other styles

12

Wilkie, JS, and KN Winzenberg. "Preparation of Some 9-Hydroxy-2-oxaspiro[4.5]dec-8-ene-1,7-dione Derivatives by Reductive Alkylation of 3,5-Dimethoxybenzoic Acid With 1,2-Dihaloalkane and Oxiran Electrophiles." Australian Journal of Chemistry 42, no. 8 (1989): 1207. http://dx.doi.org/10.1071/ch9891207.

Full text

Abstract:

Lithium in liquid ammonia mediated reductive alkylation of 3,5-dimethoxybenzoic acid (3) with 1,2-dibromoethane, or 1-bromo-2-chloroethane, followed by acid hydrolysis, afforded 9-hydroxy-2-oxaspiro[4.5]dec-8-ene-1,7-dione (1a). Reductive alkylation of (3) with unbranched 1,2-dibromoaikanes (5b-g), 1,2-dibromo-3-methylbutane and 1,2-dibromo-3,3-dimethylbutane gave 3-alkyl-9-hydroxy-2-oxaspiro[4.5]dec-8-ene-1,7-dione derivatives (1b-i) in moderate yields with the exception of (1i). The major product of the last reaction was 1-(2-bromo-3,3- dimethylbutyl )-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylic acid (9). No reductive alkylation of (3) was observed with 2,3-dibromobutane or 1,2-dibromo-2methylpropane. Reductive alkylation of (3) with the oxiran derivatives (8a-d) afforded the 2-oxaspiro[4.5]dec-8-ene-1,7- dione derivatives (1a-c,j). Reductive alkylation of (3) with 1,3-dibromopropane and l-bromo-3-chloropropane gave, after hydrolysis, 1-(3-bromopropyl)-3-hydroxy-5-oxocyclohex-3-ene-l- carboxylic acid (12a) and 1-(3-chloropropyl)-3-hydroxy-5-oxocyclohex-3-ene-1-carboxylic acid (12b). The conversion of (1a) into 8-[1-( ethoxyimino )butyl]-9-hydroxy-2-oxaspiro[4.5]dec-8-ene-1,7-dione (2a) is described.

APA, Harvard, Vancouver, ISO, and other styles

13

Cannon, JR, VA Patrick, and AH White. "The Crystal-Structures of (±)-(E)-2-(1-Amino-Ethylidene)-4,4,6-Trimethylcyclohexane-1,3-Dione [(±)-Aminoangustione] and (E)-2-(1-Aminoethylidene)-4,6,6-Trimethylcyclohex-4-Ene-1,3-Dione (Aminodehydroangustione)." Australian Journal of Chemistry 39, no. 6 (1986): 923. http://dx.doi.org/10.1071/ch9860923.

Full text

Abstract:

The crystal structures of (�)-(E)-2-(1-aminoethylidene)-4,4,6- trimethylcyclohexane-1,3-dione [(�)- aminoangustione ] (8) and (E)-2-(1- aminoethylidene )-4,6,6-trimethylcyclohex-4-ene-1,3-dione ( aminodehydroangustione ) (9) have been determined by X-ray diffraction. Diffractometer data at 295 K were refined by full-matrix least-squares to residuals of 0.057 (712 'observed' reflections) for (8) and 0.061 (571) for (9). Crystals of (8) are tetragonal I 41/a, a 21.68(1), c 9.426(6)Ǻ, Z 16; crystals of (9) are orthorhombic Pmab , a 7.077(2), b 11.421(6), c 13.283(4)Ǻ, Z 4.

APA, Harvard, Vancouver, ISO, and other styles

14

Mehdi, Sayed Hasan, Rokiah Hashim, Raza Murad Ghalib, Chin Sing Yeap, and Hoong-Kun Fun. "9-(3,4-Dimethoxyphenyl)-3,4,5,6,7,9-hexahydroxanthene-1,8(2H)-dione." Acta Crystallographica Section E Structure Reports Online 67, no. 6 (2011): o1449. http://dx.doi.org/10.1107/s1600536811017867.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Ammon, H. L., and L. A. Paquette. "Structure of 9-nitro-[4]peristylane-1,5-dione." Acta Crystallographica Section C Crystal Structure Communications 47, no. 10 (1991): 2156–59. http://dx.doi.org/10.1107/s0108270191003980.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Lokaj, J., V. Kettmann, and S. Marchalin. "4,6,7,8,8a,9-Hexahydrothieno[3,2-f]indolizine-6,9-dione." Acta Crystallographica Section C Crystal Structure Communications 55, no. 7 (1999): 1103–5. http://dx.doi.org/10.1107/s0108270199001055.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Zhu, Yu-Lin, Shen-Lin Huang, and Yuan-Jiang Pan. "9-Butyl-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione." Acta Crystallographica Section E Structure Reports Online 61, no. 4 (2005): o1139—o1140. http://dx.doi.org/10.1107/s1600536805006501.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Kour, Dalbir, D. R. Patil, M. B. Deshmukh, Vivek K. Gupta, and Rajni Kant. "Synthesis and X-Ray Crystal Structure of Two Acridinedione Derivatives." Journal of Crystallography 2014 (February 27, 2014): 1–8. http://dx.doi.org/10.1155/2014/914504.

Full text

Abstract:

The two acridinedione derivatives 1 [3,3,6,6-tetramethyl-9-(4-methoxyphenyl)-3,4,6,7,9,10-hexahydro-2H,5H-acridine-1,8-dione (C24H29NO3)] and 2 [3,3,6,6-tetramethyl-9-(4-methylphenyl)-3,4,6,7,9,10-hexa-hydro-2H,5H-acridine-1,8-dione (C24H29NO2)] were synthesized and their crystal structures were determined by direct methods. The asymmetric unit of compound 1 contains two independent molecules. The 1,4-dihydropyridine (DHP) ring adopts boat conformation in both 1 and 2. In 1 the dione rings exist in sofa conformation (for both the crystallographically independent molecules) while the corresponding rings in 2 adopt half chair and sofa conformations, respectively. The crystal packing is stabilized by intermolecular N–H⋯O and C–H⋯O interactions in compound 1 and N–H⋯O interactions in compound 2.

APA, Harvard, Vancouver, ISO, and other styles

19

Neda, Ion, Michael Farkens, Axel K. Fischer, Peter G. Jones та Reinhard Schmutzler. "Zur Chemie der 1,3,5-Triaza-2-phosphorinan-4,6-dione. Teil IX. Umsetzungen einiger 1,3,5-Triorgano-1,3,5-triaza-2λ3-phosphorinan-4,6-dione mit Hexafluoraceton / Chemistry of the 1,3,5-Triaza-2-phosphorinan-4,6-diones. Part IX. Reaction of some 1,3,5-Triorgano-1,3,5-triaza-2λ3-phosphorinan-4,6-diones with Hexafluoroacetone". Zeitschrift für Naturforschung B 50, № 12 (1995): 1785–90. http://dx.doi.org/10.1515/znb-1995-1203.

Full text

Abstract:

The reactions of 2-(2-chloroethyl)amino-1,5-dimethyl-3-phenyl-1,3,5-triaza-2λ3-phosphorinan- 4,6-dione (1), 2-bis(2-chloroethyl)amino-1,5-dimethyl-3-phenyl-1,3,5-triaza-2A3-phosphorinan- 4,6-dione (2), 2-methoxy-1,3,5-trimethyl-1,3,5-triaza-2λ3-phosphorinan-4,6-dione (3) and 2-trimethylsiloxy-1,3,5-trimethyl-1,3,5-triaza-2λ3-phosphorinan-4,6-dione (5) with hexafluoracetone are described. In the case of 2 and 3 the reaction furnished the spirocyclic compounds 7 and 8. 2-Bis(2-chloroethyl)amino-1,3,5-triphenyl-1,3,5-triaza-2λ3-phosphorinan- 4,6-dione (4) did not react. In the case of 1 and 5 rearrangement reactions took place; the (2-chloroethyl)amino substituent of 1 reacted with one of two equivalents of hexafluoroacetone with formation of the spirocyclic phosphorane 6. The reaction of 5 with tetrabromoorthobenzoquinone gave the phosphoryl compound 9. Compounds 6 - 8 were characterized via their 1H-, 13C-, 19F- and 31P-NMR and mass spectra, compound 9 via its 1H-, 13C- and 31P-NMR and mass spectra. An X-ray crystal structure determination of 8 was conducted; in the six-membered ring the phosphorus atom lies 73 pm out of the plane of the other atoms, and displays trigonal bipyramidal coordination.

APA, Harvard, Vancouver, ISO, and other styles

20

Taghavi-Moghadam, Shahriyar, Rüdiger Stumpf, Helmut Fischer, and Wolfgang Pfleiderer. "Facile Synthesis of 6-Aryl-1,3-dimethyl-5H-pyrimido[4,5-b][1,4]diazepine-2,4(1H,3H)-diones." Collection of Czechoslovak Chemical Communications 64, no. 2 (1999): 313–20. http://dx.doi.org/10.1135/cccc19990313.

Full text

Abstract:

A facile procedure for the preparation of 6-aryl-1,3-dimethyl-5H-pyrimido[4,5-b][1,4]diazepine2,4(1H,3H)-diones 8, 9 from 6-amino-5-arylideneamino-1,3-dimethyluracils 1, 2 and triethyl orthoacetate (3) in a two-step reaction via 6-aryl-8-ethoxy-6,7-dihydro-1,3-dimethyl-5H-pyrimido[4,5-b][1,4]diazepine-2,4(1H,3H)-diones 6, 7 is described. Condensation of 1 with diethoxymethyl acetate (10) resulted in the formation of (1,3-dimethyl-2,6-(1H,3H)-dioxopurin-7-yl)(phenyl)methyl acetate (11) and a small amount of 1,3-dimethyl-6-phenylpyrazino[2,3-d]pyrimidine-2,4(1H,3H)-dione (12). The structures of 6 and 11 were unambiguously confirmed by single-crystal X-ray diffraction analysis.

APA, Harvard, Vancouver, ISO, and other styles

21

R., N. Prasad, Mohan Sharma Kirti та Agrawal Anjali. "Synthesis and characterization of mixed ligand complexes of cobalt(II) with 2-hydroxy-1-naphthaldehyde and salicylaldehyde, hydroxyaromatic ketones or β-diketones". Journal Of Indian Chemical Society Vol. 84, Jan 2007 (2007): 34–36. https://doi.org/10.5281/zenodo.5810271.

Full text

Abstract:

Department of Chemistry, University of Rajasthan, Jaipur-302 004, Rajasthan, India <em>E-mail </em>: prasadraghunandan@yahoo.com <em>Manuscript received 25 July 2006, revised 9 November 2006, accepted 10 November 2006</em> Mixed ligand complexes of general formula [Co(L)(L')(H<sub>2</sub>O)<sub>2</sub>] (where HL = 2-hydroxy·l-naphthaldehyde, HL' = 2-hydroxyacetophenone, 2-hydroxypropiophenone, 2-hydroxybenzophenone, pentane-2;4-dione, 1 phenyl butane-1 ,3-dione or 1,3-diphenylpropane-1,3-dione) have been synthesized and characterized by elemental analyses, TLC, conductances, magnetic moments, IR and electronic spectra.

APA, Harvard, Vancouver, ISO, and other styles

22

Lozinski, Oleg, Tatyana Shokol, Oleg Shishkin, Vladimir Medvediev, and Vladimir Khilya. "The redeeming features of reaction of the 8-formyl-7-hydroxychromones with malononitrile." French-Ukrainian Journal of Chemistry 2, no. 1 (2014): 10–15. http://dx.doi.org/10.17721/fujcv2i1p10-15.

Full text

Abstract:

A range of 4H,8H-pyrano[2,3-f]chromen-4,8-diones have been prepared using Knoevenagel reaction of the 8-formyl-7-hydroxychromones with malononitrile. The 4H,8H-pyrano[2,3-f]chromen-4,8-dione derivative was also obtained through the acid hydrolysis of the 8-imino-4H,8H-pyrano[2,3-f]chromen-4-one. 8-Formyl-7-hydroxychromone 1 was found to add two molecules of malononitrile through Michael addition resulting in formation of the 2-[8-amino-3-(4-chlorophenyl)-9-cyano-2-methyl-4-oxo-4H,10H-pyrano[2,3-f]chromen-10-yl]malononitrile.

APA, Harvard, Vancouver, ISO, and other styles

23

V., K. AHLUWALIA, DUTTA UTTARA, and R. SHARMA H. "Synthesis of some 1-Substituted-3-methyl-5- (2',4',6'- trimethoxyphenyl)-4-(N1-substituted-p-sulphamylbenzeneazo)pyrazoles as Potential Antifungal and Antibacterial Agents." Journal of Indian Chemical Society Vol. 64, Apr 1987 (1987): 221–23. https://doi.org/10.5281/zenodo.6198625.

Full text

Abstract:

Department of Chemistry, University of Delhi, Delhi-110 007 <em>Manuscript received 25 August 1986, accepted 9 March 1987</em> Coupling of 1-methyl-3-(2',4',6'-trimethoxyphenyl)propan-1,3-dione (1) with different diazotised sulphonamide bases gives the corresponding 1-methyl-3(2',4 ,6'-trimethoxyphenyl)-2-(N'-substituted-p-sulhpamylbenzeneazo)propan-1,3-diones (2a - 1). Subsequent cyclisation with substituted hydrazines yields the pyrazole derivatives 3a - f, 3k, 3l and 4a -j. The antifungal and antibacterial activities of these compounds have been evaluated and some of them were found to exhibit considerable activity.

APA, Harvard, Vancouver, ISO, and other styles

24

Huang, Shi‐Liang, Yi Luo, Zhi‐Shu Huang, et al. "Synthesis and Cytotoxicity of 9‐Substituted Benzo[de]chromene‐7,8‐dione and 5‐Benzyl‐9‐substituted Benzo[de]chromene‐7,8‐dione." Synthetic Communications 36, no. 18 (2006): 2667–84. http://dx.doi.org/10.1080/00397910600764683.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Hřebabecký, Hubert, and Antonín Holý. "Synthesis of Carbocyclic 4'-C-Hydroxymethyl Analogues of Azidodeoxythymidine, Deoxythymidine, Deoxydidehydrothymidine and Thymidine Carba Analogue with Fused Oxetane Ring." Collection of Czechoslovak Chemical Communications 65, no. 3 (2000): 395–406. http://dx.doi.org/10.1135/cccc20000395.

Full text

Abstract:

Tosylation of (±)-1-[trans-4-hydroxy-3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)-dione (1) and (±)-1-[cis-4-hydroxy-3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)-dione (2) and treatment of the obtained 1-{(1R*,3R*,4S*)- 4-hydroxy-3-(hydroxymethyl)-3-[(tosyloxy)methyl]cyclopentyl}-5-methylpyrimidine- 2(1H),4(3H)-dione (6) and 1-{(1R*,3S*,4R*)-4-hydroxy-3-(hydroxymethyl)-3-[(tosyloxy)- methyl]cyclopentyl}-5-methylpyrimidine-2(1H),4(3H)-dione (9) with methanolic sodium methoxide gave 1-[(1R*,4S*,6S*)-4-hydroxymethyl-2-oxabicyclo[3.2.0]hept-6-yl]-5-methylpyrimidine-2(1H),4(3H)-dione (7) and 1-[(1R*,4S*,6R*)-4-hydroxymethyl-2-oxabicyclo[3.2.0]hept-6-yl]-5-methylpyrimidine-2(1H),4(3H)-dione (10), respectively. Treatment of (±)-1-{cis-4-mesyloxy-3,3-bis[(trityloxy)methyl]cyclopentyl}-5-methylpyrimidine-2(1H),4(3H)-dione (11), which was prepared from 2 by tritylation and mesylation, with 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethylformamide afforded after deprotection (±)-1-[4,4-bis(hydroxymethyl)cyclopent-2-en-1-yl]-5-methylpyrimidine-2(1H),4(3H)-dione (14). Hydrogen- ation of 14 led to (±)-1-[3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)- dione (15). (±)-1-{trans-4-Mesyloxy-3,3-bis[(trityloxy)methyl]cyclopentyl}-5-methylpyrimidine- 2(1H),4(3H)-dione (17), which was prepared from 1, was converted to (1R*,9R*)-6-methyl-5-oxo-11,11-bis(trityloxymethyl)-2-oxa-4,8-diazatricyclo[7.2.1.03,8]dodec-3,6-diene (18). The compound 18 was deprotected and heated with lithium azide in dimethylformamide to give (±)-1-[trans-4-azido-3,3-bis(hydroxymethyl)cyclopentyl]-5-methylpyrimidine-2(1H),4(3H)-dione (21).

APA, Harvard, Vancouver, ISO, and other styles

26

Frister, Hermann, and Eckhard Schlimme. "Ringöffnungsreaktionen an bioreaktiven Lactamsystemen / Ring Opening Reactions of Bioreactive Lactam Systems." Zeitschrift für Naturforschung C 42, no. 5 (1987): 603–12. http://dx.doi.org/10.1515/znc-1987-0518.

Full text

Abstract:

Abstract 1-β-ᴅ-Ribofuranosylpyrrolidin-2,5-dione (9) was synthesized by ribosylation of N-silylated succinimide (7) with 1,2,3,5-tetra-O-acetyl-β-ᴅ-ribofuranose in acetonitril in the presence of tin tetrachloride. The compounds 9, 1-β-ᴅ-ribofuranosyl-l-H-pyrrol-2,5-dione (5) and N-methyl- maleinimide (2) were converted with ammonia to the ring-opened components 16. 14 and 15. The bioreactivity of the N-maleinimide derivatives 2 and 5 with respect to addition and ring-opening reactions with amino acid side chains containing either thiol or amino groups was shown in model reactions with glutathion (compds. 17,18) and lysine (compds. 19, 20). The ring opening reaction of 3-methyl-3-phenyl-1-β-ᴅ-ribofuranosylpyrrolidin-2,5-dione (11) with lysine yields 21, thus demonstrating the possibility of glycosuccinylation of amino groups in proteins.

APA, Harvard, Vancouver, ISO, and other styles

27

Guo, Cheng, Shujiang Tu, Tuanjie Li, and Songlei Zhu. "9-(4-Methoxyphenyl)-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione." Acta Crystallographica Section E Structure Reports Online 60, no. 11 (2004): o2035—o2037. http://dx.doi.org/10.1107/s1600536804025796.

Full text

APA, Harvard, Vancouver, ISO, and other styles

28

Tu, Shu-Jiang, Xu Deng, Miao Du, Ya-Yin Fang, Ya-Mei Guo, and Xiao-Hong Liu. "9-(4-Chlorophenyl)-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 57, no. 5 (2001): o383—o385. http://dx.doi.org/10.1107/s1600536801005189.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

Tu, Shu-Jiang, Yan Zhang, and Xiao-Jing Zhang. "10-Cyclopropyl-9-(4-methoxyphenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 61, no. 6 (2005): o1885—o1887. http://dx.doi.org/10.1107/s1600536805016168.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Rong, Liang-Ce, Xiao-Yue Li, Chang-Sheng Yao, Hai-Ying Wang, and Da-Qing Shi. "9-(2-Chlorophenyl)-1,2,3,4,5,6,7,8,9,10-decahydro-3,3,6,6-tetramethylacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 62, no. 6 (2006): o2380—o2381. http://dx.doi.org/10.1107/s1600536806017788.

Full text

APA, Harvard, Vancouver, ISO, and other styles

31

Li, Yuling, Xiangshan Wang, Daqing Shi, Baixiang Du, and Shujiang Tu. "3,3,6,6-Tetramethyl-9-(3,4-methylenedioxylphenyl)-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 59, no. 10 (2003): o1446—o1448. http://dx.doi.org/10.1107/s1600536803019378.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Wen, Zhi-Gang, and Jia-Ming Li. "Redermination of 9,9′-bianthracene-10,10′(9H,9′H)-dione." Acta Crystallographica Section E Structure Reports Online 64, no. 10 (2008): o1931. http://dx.doi.org/10.1107/s1600536808028833.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Kawade, Vitthal, Anupa Kumbhar, Avinash Sapre, and Avinash Kumbhar. "Photophysical properties of 3-(9-anthrylmethyl) pentane-2,4-dione." Chemical Physics Letters 583 (September 2013): 198–202. http://dx.doi.org/10.1016/j.cplett.2013.07.071.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Rong, Liang-Ce, Xiao-Yue Li, Chang-Sheng Yao, Hai-Ying Wang, and Da-Qing Shi. "9-(3,4-Dichlorophenyl)-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 62, no. 4 (2006): o1326—o1327. http://dx.doi.org/10.1107/s1600536806007951.

Full text

Abstract:

The title compound, C23H25Cl2NO2, was synthesized by the reaction of 5,5-dimethylcyclohexane-1,3-dione with 3,4-dichlorobenzaldehyde and ammonium acetate under solvent-free conditions at 353 K. X-ray analysis reveals that the dihydropyridine and cyclohexene rings adopt envelope conformations.

APA, Harvard, Vancouver, ISO, and other styles

35

Kant, Rajni, Vivek K. Gupta, Kamini Kapoor, D. R. Patil, S. D. Jagadale, and Madhukar B. Deshmukh. "9-(3-Fluorophenyl)-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 69, no. 1 (2012): o101. http://dx.doi.org/10.1107/s1600536812050556.

Full text

APA, Harvard, Vancouver, ISO, and other styles

36

Kant, Rajni, Vivek K. Gupta, Kamini Kapoor, D. R. Patil, D. R. Chandam, and Madhukar B. Deshmukh. "9-(3,4-Dimethoxyphenyl)-3,3,6,6-tetramethyl-1,2,3,4,5,6,7,8,9,10-decahydroacridine-1,8-dione." Acta Crystallographica Section E Structure Reports Online 69, no. 2 (2013): o297—o298. http://dx.doi.org/10.1107/s1600536813002250.

Full text

Abstract:

The asymmetric unit of the title compound, C25H31NO4, contains two independent molecules. In one molecule, the benzene ring and an attached methoxy group were refined as disordered over two sets of sites in a 0.65 (4): 0.35 (4) ratio. In both molecules, the central ring of the acridinedione system adopts a flattened boat conformation. The four essentially planar atoms of this ring [maximum deviations = 0.006 (5) Å in both molecules] forms dihedral angles of 86.8 (2) and 87.6 (2)°, respectively, with the major and minor components in the disordered benzene ring and 87.3 (2)° with the benzene ring in the fully ordered molecule. The two outer rings of the acridinedione system adopt sofa conformations in both molecules. In the crystal, N—H...O hydrogen bonds form two independent chains along [100]. C—H...O hydrogen bonds link the chains, forming a three-dimensional network.

APA, Harvard, Vancouver, ISO, and other styles

37

Mirochnik, Anatolii G., Anton Yu, Beloliptsev, and Elena V. Fedorenko. "Dual Luminescence of 1‐(9‐Anthryl)Butane‐1,3‐dione." ChemistrySelect 5, no. 2 (2020): 710–16. http://dx.doi.org/10.1002/slct.201904327.

Full text

APA, Harvard, Vancouver, ISO, and other styles

38

Leppik, R. A., та D. J. Sinden. "Pseudomonas μtant strains that accumulate androstane and seco-androstane intermediates from bile acids". Biochemical Journal 243, № 1 (1987): 15–21. http://dx.doi.org/10.1042/bj2430015.

Full text

Abstract:

Transposon mutant strains which were affected in bile acid catabolism were isolated from four Pseudomonas spp. Two of the mutant groups isolated were found to accumulate 12 alpha-hydroxyandrosta-1,4-diene-3,17-dione as the major product from deoxycholic acid. Strains in one of these two groups were able to grow on steroids such as chenodeoxycholic acid, which lacks a 12 alpha-hydroxy function, whereas the one member of the second group could not. With chenodeoxycholic acid, this latter strain accumulated a yellow muconic-like derivative, tentatively identified as 3,7-dihydroxy-5,9,17-trioxo-4(5),9(10)-disecoandrosta-1(10)2 -dien-4-oic acid. Members of two further mutant groups accumulated either 12 beta-hydroxyandrosta-1,4-diene-3,17-dione or 3,12 beta-dihydroxy-9(10)-secoandrosta-1,3,5(10)-triene-9,17-dione as the major product from deoxycholic acid. The relationship between the catabolism of m- and p-cresol, 3-ethylphenol and the bile acids was also examined.

APA, Harvard, Vancouver, ISO, and other styles

39

Piggott, Matthew J., and Dieter Wege. "The Synthesis of 5-Hydroxy-3-methylnaphtho[2,3-c]furan-4,9-dione and 5,8-Dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione." Australian Journal of Chemistry 56, no. 7 (2003): 691. http://dx.doi.org/10.1071/ch02253.

Full text

Abstract:

5-Hydroxy-3-methylnaphtho[2,3-c]furan-4,9-dione (1), a metabolite isolated from Aloe ferox and Bulbine capitata, has been synthesized by a sequence involving an annulation reaction between the anion of 4-methoxy-3-oxo-1,3-dihydroisobenzofuran-1-carbonitrile (8) and (E)-pent-3-en-2-one, followed by subsequent construction of the furan ring through allylic bromination, hydrolysis, and dehydration as the key steps. The formation of several unusual products observed in annulation reactions between (8) and O-protected derivatives of (E)-5-hydroxypent-3-en-2-one (9) can be rationalized by invoking the intermediacy of a reactive o-quinone methide. 5,8-Dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione (2), another naturally occurring naphtho[2,3-c]furan-4,9-dione, has been prepared by a Friedel–Crafts acylation of 1,4-dimethoxybenzene with 2-methylfuran-3,4-dicarbonyl dichloride. Arguments are presented that 5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione is a better structural representation than the alternative 4,9-dihydroxynaphtho[2,3-c]furan-5,8-dione tautomer in such systems, as the latter would contain a reactive isobenzofuran moiety.

APA, Harvard, Vancouver, ISO, and other styles

40

Purushothaman, Gayathri, and Vijay Thiruvenkatam. "Qualitative and quantitative analysis of intermolecular interactions in xanthenedione derivatives." Acta Crystallographica Section C Structural Chemistry 74, no. 7 (2018): 830–38. http://dx.doi.org/10.1107/s205322961800832x.

Full text

Abstract:

The existence of intermolecular interactions and the conformational geometry adopted by molecules are related to biological activity. Xanthenedione molecules are promising and emerging antioxidants and acetylcholinesterase inhibitors. To examine the role of different functional groups involved in the intermolecular interactions and conformational geometries adopted in xanthenediones, a series of three substituted xanthenediones have been crystallized [9-(3-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione, C23H26O4, 9-(5-bromo-2-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7-tetrahydro-2H-xanthene-1,8(5H,9H)-dione, C24H27BrO4, and 3,3,6,6-tetramethyl-9-(pyridin-2-yl)-3,4,6,7-tetrahydro-2H-xanthene-1,8(5H,9H)-dione, C22H25NO3] and their intermolecular interactions analyzedviaHirshfeld analysis. The results show that all the derivatives adopt the same structural conformation, where the central ring has a shallow boat conformation and the outer rings have a twisted boat conformation. The intermolecular interactions in the molecules are predominantly O—H...O, C—H...O and π–π interactions. The optimized structures of the derivatives from theoretical B3LYP/6-311G** calculations show a good correlation with the experimental structures. The lattice energy involved in the intermolecular interactions has been explored usingPIXELC.

APA, Harvard, Vancouver, ISO, and other styles

41

Huy, Luu D., Nguyen T. Diep, Tran K. Vu, Tatiana S. Savinova, and Marina V. Donova. "An Efficient Procedure for the Synthesis of 21-Acetoxypregna-1,4,9(11),16- tetraene-3,20-dione." Combinatorial Chemistry & High Throughput Screening 23, no. 3 (2020): 225–31. http://dx.doi.org/10.2174/1386207323666200219122644.

Full text

Abstract:

Background: Halogenated corticosteroids are widely used in medicine, and the global need of these steroidal APIs is estimated to be 40 – 70 tons, annually. Vietnam currently imports the pharmaceutical compounds up to 90%, in particular 100% of steroidal drugs. Currently, industrial production is based on the chemical syntheses of corticosteroids from either 16- dehydropregnenolone acetate (obtained from diosgenin) or androstenedione (obtained from phytosterol). The development of shorter synthetic schemes and more economically feasible technologies is of great significance. Introduction of 1(2)-double bond at the final stages of the corticosteroids synthesis results inpoor yield. 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione (tetraene acetate) is a key intermediate in the synthesis of highly active halogenated corticosteroids such as dexamethasone and other halogenated corticosteroids. 21-acetoxypregna-1,4,9(11),16- tetraene-3,20-dione is a key intermediate in the synthesis of dexamethasone from the readily available and cheap 9α-hydroxyandrost-4-ene-3,17-dione. Objective: The purpose of this study was the development of an efficient and shorter procedure for the synthesis of 21-acetoxypregna-1,4,9(11),16-tetraene-3,20-dione from 9α-hydroxyandrostenedione, which is a product of a bio-oxidative degradation of the side chain of phytosterols. Methods: Pregnane side chain was constructed using cyanohydrin method. For 1(2)- dehydrogenation, selene dioxide was applied for the introduction of Δ1(2)-double bond. Other stages of the synthesis were epimerization, Stork’s iodination procedure and dehydration. Result: 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione was prepared from 9α- hydroxyandrostenedione in yield more than 46%. Conclusion: An efficient and practically feasible procedure for the synthesis of 21-acetoxypregna- 1,4,9(11),16-tetraene-3,20-dione from 9α-hydroxyandrostenedione, a key intermediate for the synthesis of 9-haloidated corticoids, has been developed. The procedure can be applied for the production of value-added 9-haloidated corticoids.

APA, Harvard, Vancouver, ISO, and other styles

42

Tang, Huai Jun, Li Ying Wei, Qian Luo, Xian Wang Shen, and Chang Li Liu. "Effect of 1-(9-Ethyl-9H-carbazol-3-yl)-4,4,4-trifluorobutane-1,3-dione on Properties of Luminescent Europium (III) Complexes." Advanced Materials Research 834-836 (October 2013): 215–20. http://dx.doi.org/10.4028/www.scientific.net/amr.834-836.215.

Full text

Abstract:

In order to understand the effect of β-diketone ligands containing carbazole group on luminescent europium (III) complexes, a series of europium (III) complexes (Phen)Eu (DBM)3-nLnwith 1-(9-Ethyl-9H-carbazol-3-yl)-4,4,4-trifluorobutane-1,3-dione (L) were synthesized and investigated contrastively (n = 0, 1, 2, 3; DBM: dibenzoylmethane; Phen: 1,10-phenanthroline). The results show amorphous nature, glass transition temperatures and luminescent intensity can be improved obviously by 1-(9-ethyl-9H-carbazol-3-yl)-4,4,4-trifluorobutane-1,3-dione, at the same time, their thermal decomposition temperatures have seldom effected by it. The results verify the performance of europium (III) complexes used as luminescent materials can be effectively improved by the β-diketone ligands of this type.

APA, Harvard, Vancouver, ISO, and other styles

43

Visagaperumal, D., V. Chandy, K. Jayakumar, and N. Anbalagan. "SYNTHESIS AND ANALGESIC ACTIVITY OF 7-(SUBSTITUTED PHENYL)-9- PHENYL-1H-[1,4]DIAZEPINO [2,3-G] QUINOXALINE-2,3(4H,6H)-DIONES." INDIAN DRUGS 53, no. 12 (2016): 5–10. http://dx.doi.org/10.53879/id.53.12.10248.

Full text

Abstract:

A series of 7-substituted phenyl-9-phenyl-1H-[1,4]diazepino[2,3-g]quinoxaline-2,3(4H,6H)-dione (SK1-SK9) was synthesized by the reaction of 6,7-diaminoquinoxaline-2,3(1H,4H)-dione 3 with substituted chalcone with good yield and characterized by elemental and spectral analysis (IR, 1H NMR, Mass). The synthesized compounds were screened for analgesic activity by tail immersion method. The results revealed that the compound SK6 was significant from this series.

APA, Harvard, Vancouver, ISO, and other styles

44

Brown, RFC, FW Eastwood, and BE Kissler. "The Mechanism of Formation of Acenaphthylene on Pyrolysis of 8-Methylcyclobuta[a]naphthalene-1,2-dione." Australian Journal of Chemistry 42, no. 9 (1989): 1435. http://dx.doi.org/10.1071/ch9891435.

Full text

Abstract:

Flash vacuum pyrolysis of the l-13C labelled title dione (13) gives acenaphthylene labelled predominantly at C4 (65.9%) and C1 (27.6%). This is in accord with the intermediacy of the (labelled) acyloxycarbene (5), the lactone (6) and the carbene (7). The minor leakage of label to C3 (5.8%) and C5 (0.7%) is discussed. Irradiation of labelled dione (13) in methanol with ultraviolet light gives 3-methoxy-9-methyl[1-13C] naphtho [1,2-c]furan-1(3H)-one (19).

APA, Harvard, Vancouver, ISO, and other styles

45

Pinchuk, Vasily A., Ion Neda, Thomas Kaukorat, et al. "Zur Chemie der 1,3,5-Triaza-2-phosphorin-4,6-dione, Teil XIII. Darstellung und Röntgenstrukturanalyse des 1,3,5-Trimethyl-2-trichlormethyl-Derivats. Reaktionen einiger 1,3,5-Trimethyl-1,3,5-triaza-2-(R)-phosphorin-4,6-dione/Chemistry of the l,3,5-Triaza-2-phosphorine-4.6-diones, Part XIII. Synthesis and X -Ray Crystal Structure Determination of the 1,3,5-Trimethyl-2- trichlorom ethyl Derivative. Reactions of Some 1,3,5-Trimethyl-1,3,5-triaza-2-(R )-phosphorine-4,6-diones." Zeitschrift für Naturforschung B 52, no. 12 (1997): 1510–16. http://dx.doi.org/10.1515/znb-1997-1212.

Full text

Abstract:

Abstract Upon heating 1,3,5-trimethylbiuret (1) with trichloromethyldichlorophosphine in the presence of triethylamine, 2-trichloromethyl-1,3,5-trimethyl-1,3,5-triaza-2σ3λ3-phosphorine-4,6-dione (2) was obtained in good yield. Aside from NMR spectroscopic characterization, compound 2 was investigated by X-ray crystal structure analysis, representing the first case of the solid state characterization of a 2-trihalomethyl-1,3,5-trimethyl-1,3,5-triaza-2σ3λ3-phosphorine-4,6-dione derivative. The heterocycle presents an envelope conformation with phosphorus out of the plane of the other atoms. Reaction of the monochloromethyl derivative (3) corresponding to 2, with a sterically demanding azide led by oxidation of phosphorus to the stable σ4λ5-P derivative (4). 2-Hydro-1,3,5-trimethyl-1,3,5-triaza-2-oxo-2σ4λ5-phosphorine-4,6-dione (5) reacted with p-nitrobenzylidene benzylimine with formation of 6 by insertion of the C=N double bond of the imine into the P-H bond. Intramolecular hydrogen bonding in 6 was observed by 1H NMR and IR spectroscopy. Reaction of 2-(methylamino)-methyl-1,3,5-trimethyl-1,3,5-triaza-2-oxo-2σ4λ5-phosphorine-4,6-dione (7) with diethylamino-trimethylsilane led to the corresponding N-trimethylsilylated compound 8. Compound 9. bearing a peptoid group, was formed by reaction of 7 or 8 with 3-(chloroformyl)propionic acid methyl ester. The preferred method of synthesis of 9 is indicated.

APA, Harvard, Vancouver, ISO, and other styles

46

Forsyth, Craig M., and Craig L. Francis. "Crystal structures of two 2,3-diethylnaphtho[2,3-g]quinoxaline-6,11-dione derivatives." Acta Crystallographica Section E Crystallographic Communications 73, no. 8 (2017): 1125–29. http://dx.doi.org/10.1107/s2056989017009641.

Full text

Abstract:

Two new 5,12-disubstituted 2,3-diethylnaphtho[2,3-g]quinoxaline-6,11-dione compounds were readily synthesized from the commercial dye quinizarin. For 2,3-diethyl-5,12-dihydroxynaphtho[2,3-g]quinoxaline-6,11-dione, (II), C20H16N2O4, the molecule displays a near planar conformation and both hydroxy groups participate in intramolecular O—H...O(carbonyl) hydrogen bonds. In the crystal, π–π ring interactions [minimum ring centroid separation = 3.5493 (9) Å] form stacks of co-planar molecules down the c axis, while only minor intermolecular C—H...O interactions are present. In contrast, in 2,3-diethyl-5,12-bis(piperidin-1-yl)naphtho[2,3-g]quinoxaline-6,11-dione, (IV), C30H34N4O2, which contains two independent, but similar, molecules in the asymmetric unit, the polycyclic cores have a significant twist, with dihedral angles of 29.79 (6) and 29.31 (7)° between the terminal rings and only minor intermolecular C—H...O hydrogen-bonding interactions are present. Electron density associated with additional solvent molecules disordered about a fourfold axis was accounted for using the SQUEEZE procedure in PLATON [Spek (2015). Acta Cryst. C71, 9–18].

APA, Harvard, Vancouver, ISO, and other styles

47

Karichiappan, Kalanithy, and Dieter Wege. "Naphtho[2,3-c]furan-4,9-dione and a Further Exploratory Approach to the Ring System of Ventilone A." Australian Journal of Chemistry 53, no. 9 (2000): 743. http://dx.doi.org/10.1071/ch00056.

Full text

Abstract:

1,4-Dimethoxy-2,3-didehydronaphthalene (10), generated by the dehydrobromination of 2-bromo-1,4-dimethoxynaphthalene (9), was trapped with furan and 2-methylfuran, and the resulting adducts were converted into naphtho[2,3-c]furan-4,9-dione (1) and 1-methylnaphtho[2,3-c]furan-4,9-dione (19) respectively. An attempt to extend this procedure to the synthesis of ventilone A (2) failed when the adduct (31), derived from 6,7-methylenedioxy-1,4,5,8-tetramethoxy-2,3-didehydronaphthalene (30) and 2-methylfuran, could not be oxidizedselectively.

APA, Harvard, Vancouver, ISO, and other styles

48

Ebadi, Ahmad, Aref Karimi, Asrin Bahmani, Zahra Najafi, and Gholamabbas Chehardoli. "Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies." Journal of Chemistry 2024 (January 5, 2024): 1–9. http://dx.doi.org/10.1155/2024/6612503.

Full text

Abstract:

Seventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). Compound 9-(4-(benzyloxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (4a) showed good cytotoxic effects (34.59 μM) in comparison to cis-platin. Docking results showed 4a could interact with DNA as intercalation. Calculated ligand efficiency of compound 4a was more than daunomycin. Based on the results, it can be concluded that compound 4a is a suitable DNA binding agent.

APA, Harvard, Vancouver, ISO, and other styles

49

Schottenberger, Herwig, Michael Buchmeiser, Johann Polin, and Karl-Eberhard Schwarzhans. "Ferrocen-Derivate der Quadrat- und Propiolsäure. Synthesen und Reaktionen / Ferrocene Derivatives of Squaric Acid and Propiolic Acid. Syntheses and Reactions." Zeitschrift für Naturforschung B 48, no. 11 (1993): 1524–32. http://dx.doi.org/10.1515/znb-1993-1110.

Full text

Abstract:

Concepts for linking ferrocene derivatives with conjugated squarate and propiolate based spacer systems have been investigated. Coupling of 3,4-dichlorocyclobut-3-ene-1,2-dione (squaric acid dichloride) with cuproferrocene • dimethylsulfide resulted in 3-chloro-4-ferrocenylcyclobut-3-ene-1,2-dione (ferrocenylsemisquaric acid chloride) and 3,4-diferrocenylcyclobut-3-ene-1,2-dione. Ferrocenylsemisquaric acid chloride was further treated with ethynylferrocene and 4-ethynyl-4-(ferrocenylethynyl)tolan, respectively, to form the corresponding mixed squaric diketones, which required Zn/Pd mediated coupling conditions for sufficient conversion. The symmetrically substituted derivative of ferrocenylacetylene was prepared by the same method.Cupration and subsequent coupling of dilithioferrocene with one equivalent of iodopropiolic acid methyl ester yielded 1′-iodo- 1 -ferrocenylpropiolic acid methyl ester, and with two equivalents 1,16-bis(methoxycarbonylethynyl)biferrocene. Nucleophilic addition of secondary amines to ferrocenylpropiolic acid ethyl ester gave aminoacrylates as intermediates, which rapidly converted to ketoesters during workup. Only in the case of morpholine the corresponding adduct (ferrocenylmorpholino acrylate) could be isolated. 1,3-Diferrocenylprop-2-ene-1-one has been obtained in a Bénary reaction of lithioferrocene with 3-diethylaminoethyl acrylate in quantitative yield.In order to provide alternative syntheses of already known compounds the substitution behavior of different metallated ferrocene intermediates has also been evaluated by reaction with other acid halides (oxalyl chloride, thiophosgene, ethyl chloroformate).All new compounds, 3-chloro-4-ferrocenylcyclobut-3-ene-1,2-dione (1); 3,4-diferrocenylcyclobut-3-ene-1,2-dione (2); 3,4-diferrocenylethynylcyclobut-3-ene-1,2-dione (3); 3-ferrocenyl-4-ferrocenylethynylcyclobut-3-ene-1,2-dione (4); 3-ferrocenyl-4-ferrocenylethynylphenylethynylphenylethynylcyclobut-3-ene-1,2-dione (5); 3-(N-morpholino)-3-ferrocenylethyl acrylate (6); 3-ferrocenyl-3-ketoethyl propanoate (7); iodoferrocenylpropargylic acid methyl ester (8); 1,16-bis(methoxycarbonylethynyl)biferrocene (9) and trans-1,3-diferrocenylprop-2-ene-1-one [105 404-21-5], have been characterized by IR, MS and NMR and in several cases by UV/VIS and DSC.

APA, Harvard, Vancouver, ISO, and other styles

50

Barden, TJ, and MN Paddonrow. "Synthesis of Heptacyclo[7.7.0.0/2,6/0/3,15/0/4,12/0/5,10/0/11,16]-Hexadeca-7,13-Diene - a Novel Dimer of Barrelene Possessing Perpendobiplanar D2d Symmetry." Australian Journal of Chemistry 41, no. 5 (1988): 817. http://dx.doi.org/10.1071/ch9880817.

Full text

Abstract:

The synthesis of heptacyclo [7.7.0.02,6.03,15.04,12.05,10.011,16]hexadeca-7,13- diene (9) is described. The diene (9) was obtained in three steps from the known diketone heptacyclo -[6.6.0.02,6.03,13.04,11.05,9.010,14] tetradecane - 7,12-dione (5). Double ring expansion of (5) (with diazomethane) gave (12). Conversion of (12) into-the bis ( tosylhydrazone ), followed by double Bamford -Stevens rearrangement, gave the diene (9).

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!