Log in

Relevant bibliographies by topics / 9-tetrahydro-5H-[1 / Journal articles

To see the other types of publications on this topic, follow the link: 9-tetrahydro-5H-[1.

Journal articles on the topic '9-tetrahydro-5H-[1'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 34 journal articles for your research on the topic '9-tetrahydro-5H-[1.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Šilhánková, Alexandra, Petr Trška, Daniela Vlková, and Miloslav Ferles. "Preparation of some derivatives of benzo[ij]quinolizine." Collection of Czechoslovak Chemical Communications 50, no. 5 (1985): 1048–56. http://dx.doi.org/10.1135/cccc19851048.

Full text

Abstract:

Reaction of 1,2,3,4-tetrahydroquinoline with 1-chloro-2,3-epoxypropane afforded l-(3-chloro-2-hydroxypropyl)-l,2,3,4-tetrahydroquinoline (IIb) which was thermolabile and on heating in vacuo was converted into 2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizin-2-ol (Ib). This compound reacted with acetic anhydride and p-toluenesulfonyl chloride to give 2-acetoxy-2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizine (Ic) and 2-(p-toluenesulfonyloxy)-2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizine (Id), respectively. N,N-Bis(3-chloro-2-hydroxypropyl)aniline (IIIb) on heating gave a mixture of cis- and trans-2,3,

APA, Harvard, Vancouver, ISO, and other styles

2

Li, Gong, Xiaowei Wang, Zhili Zhang, and Junyi Liu. "1-Ethoxymethyl-5-methyl-9-phenyl-6,7,8,9-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepine-2,4(3H,5H)-dione." Acta Crystallographica Section E Structure Reports Online 68, no. 5 (2012): o1396. http://dx.doi.org/10.1107/s1600536812014985.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Nataliya, Demchenko, Suvorova Zinaida, Fedchenkova Yuliia, et al. "Synthesis and antibacterial activity of 3-arylaminomethyl-1-(2-oxo-2-arylethyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a] azepin-1-ium bromides and aryl-(4-R1-phenyl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulen-1-ylmethyl)-amines." ScienceRise: Pharmaceutical Science, no. 6(34) (December 30, 2021): 51–57. https://doi.org/10.15587/2519-4852.2021.249480.

Full text

Abstract:

<strong>The aim </strong>of this work is to develop methods of synthesis of 3-arylaminomethyl-1-(2-oxo-2-arylethyl)-6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-1-ium bromides and aryl-(4-R<sup>1</sup>-phenyl-5,6,7,8-tetrahydro-2,2a,8a-triazacyclopenta[cd]azulen-1-ylmethyl)-amines and to study their antimicrobial activity against strains of gram-positive and gram-negative bacteria as well as yeast fungi. <strong>Materials and methods. </strong><sup>1</sup>Н NMR spectra were recorded on Bruker 400 spectrometer operating at frequency of 400 MHz. Antimicrobial activity of the comp

APA, Harvard, Vancouver, ISO, and other styles

4

Kliegel, Wolfgang, Jörg Metge, Steven J. Rettig, and James Trotter. "Aromatic aldonitrones of 2-(hydroxyamino)benzyl alcohol and their cyclic isomers. Crystal and molecular structures of a 1-hydroxy-1,2-dihydro-4H-3,1-benzoxazine, a boron chelate, and its parent nitrone ligand." Canadian Journal of Chemistry 76, no. 4 (1998): 389–99. http://dx.doi.org/10.1139/v98-023.

Full text

Abstract:

The synthesis of a series of C-aryl-N-[2-(hydroxymethyl)phenyl]nitrones, 5 (that can also exist under certain conditions as isomeric 1-hydroxy-2-aryl-1,2-dihydro-4H-3,1-benzoxazines, 8), via 2-(hydroxyamino)benzyl alcohol, 4, and their subsequent reactions with oxybis(diphenylborane), (Ph2B)2O, leading to the 5-(arylmethylene)-7,7-diphenyl-6,8-dioxa- 5-azonia-7-borata-5H-6,7,8,9-tetrahydrobenzocyclo- heptenes 6 are described. Crystals of 1-hydroxy-2- (4-methoxyphenyl)- 1,2-dihydro-4H-3,1-benzoxazine, 8b, are monoclinic, a = 9.379(2), b = 10.699(2), c = 12.9392(7) Å, β = 99.916(2)°, Z = 4 (two

APA, Harvard, Vancouver, ISO, and other styles

5

Luo, Zhonghua, Guodong Sun, Guowei Wang, Xin Zhang, Yang Zhang, and Ji Zhang. "Efficient and Scalable Enantioselective Synthesis of a Key Intermediate for Rimegepant: An Oral CGRP Receptor Antagonist." Pharmaceutical Fronts 06, no. 01 (2024): e62-e68. http://dx.doi.org/10.1055/s-0044-1780495.

Full text

Abstract:

Rimegepant is a calcitonin gene-related peptide antagonist used for acute treatment and prevention of migraine. We herein attempt to explore an efficient and practiced method for scale-up, regio- and enantioselective synthesis of (R)-9-hydroxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-5-one (1), a key intermediate of rimegepant. In this work, a Ru-catalyzed asymmetric transfer hydrogenation (ATH) reaction was a key step. The optimization of the reaction conditions involved exploring the reaction parameters including catalysts, bases, and solvents. The results suggested that the Ru-catalyzed A

APA, Harvard, Vancouver, ISO, and other styles

6

Mansur, Muhammad Abdullah Al, M. Mahboob Ali Siddiqi, Md Ahedul Akbor, and Koushik Saha. "Phytochemical Screening and GC-MS Chemical Profiling of Ethyl Acetate Extract of Seed and Stem of Anethum sowa Linn." Dhaka University Journal of Pharmaceutical Sciences 16, no. 2 (2018): 187–94. http://dx.doi.org/10.3329/dujps.v16i2.35256.

Full text

Abstract:

Tahe phytochemical constituents from the ethyl acetate extracts of seed and stem of Anethum sowa were identified by qualitative and gas chromatography-mass spectroscopy (GC-MS). Qualitative analyses exhibited the presence of alkaloids, flavonoids, tannins, carbohydrate, steroids and terpenoids in both extracts. In GC-MS analysis of A. sowa 6 notable peaks (3,4,4a,5,6,7,8,9-Octahydro-2H-benzocyclohepten-2-one, 2,2,4,6,7-Pentamethyl- 1,2,3,4-tetrahydro quinoline, 5-Ethyl-2-methyl-pyridin-4-amine, 2-(2-Furyl) pyridine, 9-Ethyl 9-borabicyclo-[3.3.1]- nonane and 7-Methylenebicyclo-[4.2.0]-octane) a

APA, Harvard, Vancouver, ISO, and other styles

7

Banwell, MG, and CJ Cowden. "Convergent Routes to the [1,3]Dioxolo[4,5-j]phenanthridin-6(5H)-one and 2,3,4,4a-Tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(5H)-one Nuclei. Application to Syntheses of the Amaryllidaceae Alkaloids Crinasiadine, N-Methylcrinasiadine and Trisphaeridine." Australian Journal of Chemistry 47, no. 12 (1994): 2235. http://dx.doi.org/10.1071/ch9942235.

Full text

Abstract:

Convergent routes to the title nuclei, (1) and (6), have been developed. Thus, Suzuki coupling of boronic acid (8) with aryl bromide (9) gave the biarylylcarbamate (7) which, on treatment with phosphorus oxychloride (POCl3), underwent Bischler-Napieralski cyclization to give, after acid hydrolysis, the Amaryllidaceae alkaloid crinasiadine (1). The cyclization reaction proceeds via an intermediate chlorophenanthridine (11) which can be isolated and N- methylated. Hydrolysis of the resulting iminium species (17) then afforded N- methylcrinasiadine (2). On the other hand, hydrogenolytic dechlorin

APA, Harvard, Vancouver, ISO, and other styles

8

Vejdělek, Zdeněk, and Miroslav Protiva. "Potential antidepressants and tranquillizers: Synthesis of some 9-(aminoalkoxy)-2,3,6,7-tetrahydro-1H,5H-benzo[ij] quinolizines and 1-(substituted amino)-3-(1-naphthoxy)-2-propanols." Collection of Czechoslovak Chemical Communications 55, no. 5 (1990): 1290–96. http://dx.doi.org/10.1135/cccc19901290.

Full text

Abstract:

The hydrobromide of 9-hydroxyjulolidine was reacted with hydrochloride of 2-dimethylaminoethyl chloride, 2-(1-pyrrolidinyl)ethyl chloride, 2-(1-piperidinyl)ethyl chloride, and 3-dimethylaminopropyl chloride in ethanol in the presence of sodium ethoxide to give the title bases II-V which were transformed to dihydrochlorides. Heating of 1,2-epoxy-3-(1-naphthoxy)propane with 2,3,3-trimethyl-2-butylamine, 1-methylcyclopentylamine, 1-methylcyclohexylamine, 1-methylcycloheptylamine, and 10,11-dihydroxydibenzo[a,d]cycloheptene-5-amine in ethanol afforded the second part of the title compounds (VII-XI

APA, Harvard, Vancouver, ISO, and other styles

9

Soman, Anjaly, and K. N. Narayanan Unni. "Enhancement in electron transport and exciton confinement in OLEDs: role of n-type doping and electron blocking layers." European Physical Journal Applied Physics 86, no. 1 (2019): 10201. http://dx.doi.org/10.1051/epjap/2019190020.

Full text

Abstract:

Doped transport layers are essential for achieving high efficiency in organic light emitting diodes (OLEDs). We have studied the effect of doping the electron transport layer (ETL), tris-(8-hydroxyquinoline) aluminum (Alq3) with different percentages of lithium fluoride (LiF). We have also studied the effect of different electron blocking layers (EBLs) such as Tris (4-carbazoyl-9-ylphenyl)amine (TCTA), N,N'-Bis (naphthalen-1-yl)-N,N'-bis(phenyl)-benzidine(NPB), and Di-[4-(N,N-di-p-tolyl-amino)-phenyl]cyclohexane (TAPC) in an Alq3:2,3,6,7-Tetrahydro-1,1,7,7,-tetramethyl-1H, 5H, 11H −10-(2-benzo

APA, Harvard, Vancouver, ISO, and other styles

10

DeWald, Horace A., Thomas G. Heffner, Juan C. Jaen, et al. "Synthesis and dopamine agonist properties of (+)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol and its enantiomers." Journal of Medicinal Chemistry 33, no. 1 (1990): 445–50. http://dx.doi.org/10.1021/jm00163a068.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Traoré, F., M. Tod, J. Chalom, R. Farinotti, and G. Mahuzier. "1H,5H,11H-[1]Benzopyrano[6,7,8-ij]quinolizine-9-acetic acid 2,3,6,7-tetrahydro-11-oxohydrazide fluorogenic reagent for liquid chromatographic determination of aldehydes and ketones." Analytica Chimica Acta 269, no. 2 (1992): 211–22. http://dx.doi.org/10.1016/0003-2670(92)85405-u.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Ghorab, Mostafa M., Mansour S. Alsaid, Mohammed S. Al-Dosari, Fatma A. Ragab, Abdullah A. Al-Mishari, and Abdulaziz N. Almoqbil. "Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents." Acta Pharmaceutica 66, no. 2 (2016): 155–71. http://dx.doi.org/10.1515/acph-2016-0016.

Full text

Abstract:

Abstract As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxa

APA, Harvard, Vancouver, ISO, and other styles

13

Jones, P. G., H. Thönnessen, A. Fischer, et al. "The Anhydrous Racemate of the Carcinostatic Agent Cyclophosphamide and the Bicyclic Degradation Product 1-(2-Chloroethyl)tetrahydro-1H,5H-1,3,2-diazaphospholo[2,1-b][1,3,2]oxazaphosphorine 9-Oxide." Acta Crystallographica Section C Crystal Structure Communications 52, no. 9 (1996): 2359–63. http://dx.doi.org/10.1107/s0108270196004866.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Wang, Fa-Zuo, Min Zhang, Wei Sun, Qian-Qun Gu, and Wei-Ming Zhu. "5a-Hydroxy-9-methoxy-11-(3-methyl-2-butenyl)-12-(2-methyl-1-propenyl)-2,3,11,12-tetrahydro-1H,5H-pyrrolo[1′′,2′′:4′,5′]pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-5,6,14(5aH,14aH)-trione." Acta Crystallographica Section E Structure Reports Online 63, no. 4 (2007): o1859—o1860. http://dx.doi.org/10.1107/s1600536807012056.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Chan, E. J., Q. Gao, and M. Dabros. "Understanding the structure details when drying hydrate crystals of pharmaceuticals – interpretations from diffuse scattering and inter-modulation satellites of a partially dehydrated crystal." Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials 70, no. 3 (2014): 555–67. http://dx.doi.org/10.1107/s2052520614005125.

Full text

Abstract:

Simplified models for the crystal lattice of the sesquihydrate form of the hemi-sulfate salt of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazol[4,5b]pyridin-1-yl)-1-piperidine carboxylate (BMS-927711, C28H29F2N6O3+) are used to calculate diffuse diffraction features in order to develop a mechanistic understanding of the dehydration process with respect to disruption of the lattice, since a Bragg model cannot be established. The model demonstrates that what we observe when the water leaves the crystal is partial transfor

APA, Harvard, Vancouver, ISO, and other styles

16

Kashyap, Purna, Maria-Adelaide Micci, Sarina Pasricha, and Pankaj Jay Pasricha. "The D2/D3 Agonist PD128907 (R-(+)-trans-3,4a,10b-Tetrahydro-4-Propyl-2H,5H-[1]Benzopyrano[4,3-b]-1,4-Oxazin-9-ol) Inhibits Stimulated Pyloric Relaxation and Spontaneous Gastric Emptying." Digestive Diseases and Sciences 54, no. 1 (2008): 57–62. http://dx.doi.org/10.1007/s10620-008-0335-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Han, Hui, Feng Wang, Juanjuan Chen, et al. "Changes in Biothiol Levels Are Closely Associated with Alzheimer’s Disease." Journal of Alzheimer's Disease 82, no. 2 (2021): 527–40. http://dx.doi.org/10.3233/jad-210021.

Full text

Abstract:

Background: Serum homocysteine (Hcy) level is considered to be an important biomarker for Alzheimer’s disease (AD); however, the status of Hcy in brain tissue, and the association between brain and serum levels of Hcy in AD patients remain unclear. Objective: We aimed to examine whether the changes of three thiols are consistent in serum of AD patients and the brain of APP/PS1 mice, and to verify the effectiveness of Hcy as a biomarker for early AD detection. Methods: The levels of Hcy, cysteine (Cys), and glutathione (GSH) in Aβ1–42-treated PC12 cells, the brain and hippocampus of APP/PS1 mou

APA, Harvard, Vancouver, ISO, and other styles

18

Kakui, Nobukazu, and Koichi Kitamura. "Direct Evidence that Stimulation of Neuropeptide Y Y5 Receptor Activates Hypothalamo-Pituitary-Adrenal Axis in Conscious Rats via both Corticotropin-Releasing Factor- and Arginine Vasopressin-Dependent Pathway." Endocrinology 148, no. 6 (2007): 2854–62. http://dx.doi.org/10.1210/en.2007-0189.

Full text

Abstract:

An abundance of data suggests a crucial role of neuropeptide Y (NPY) as an activator of the hypothamamo-pituitary-adrenal (HPA) axis. However, there is quite limited evidence regarding receptors that mediate this response. Here, we address the possibility that Y5 receptor subtype may be responsible for NPY-induced activation of HPA axis. For this purpose, the effects of an intracerebroventricular injection of Y5-selective agonist, [cPP1–7, NPY19–23, Ala31, Aib32, Gln34]-human pancreatic polypeptide (hPP), on circulating ACTH and corticosterone in conscious rats were evaluated. Central injectio

APA, Harvard, Vancouver, ISO, and other styles

19

Witkin, J. M., D. Dijkstra, B. Levant, et al. "Protection against Cocaine Toxicity in Mice by the Dopamine D3/D2 Agonist R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol [(+)-PD 128,907]." Journal of Pharmacology and Experimental Therapeutics 308, no. 3 (2004): 957–64. http://dx.doi.org/10.1124/jpet.103.059980.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

van Vliet, L. Alexander, Nienke Rodenhuis, Durk Dijkstra, et al. "Synthesis and Pharmacological Evaluation of Thiopyran Analogues of the Dopamine D3Receptor-Selective Agonist (4aR,10bR)-(+)-trans-3,4,4a,10b- Tetrahydro-4-n-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol (PD 128907)." Journal of Medicinal Chemistry 43, no. 15 (2000): 2871–82. http://dx.doi.org/10.1021/jm0000113.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Dijkstra, Durk, Theo B. A. Mulder, Hans Rollema, Pieter G. Tepper, Jan Van der Weide, and Alan S. Horn. "Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b]1,4-oxazin-7- and -9-ols. The significance of nitrogen pka values for central dopamine receptor activation." Journal of Medicinal Chemistry 31, no. 11 (1988): 2178–82. http://dx.doi.org/10.1021/jm00119a020.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Witkin, J. M., B. Levant, A. Zapata, R. Kaminski, and M. Gasior. "The Dopamine D3/D2 Agonist (+)-PD-128,907 [(R-(+)-trans-3,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol)] Protects against Acute and Cocaine-Kindled Seizures in Mice: Further Evidence for the Involvement of D3 Receptors." Journal of Pharmacology and Experimental Therapeutics 326, no. 3 (2008): 930–38. http://dx.doi.org/10.1124/jpet.108.139212.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Blum, Jochanan, Vladimir Kogan, and Hansruedi Glatt. "Further studies on polycyclic arene sulfides. Preparation and mutagenic activity of 9, 10, 10a, 11a-tetrahydrotriphenyleno[1,2-b]-thiirene, 1a,2,3,10b-tetrahydro-5H-thiereno[3,4]benzo[1,2-b]fluorene and 1a,2,3,11b-tetrahydroacenaphtho[1′,2′:6,7]naphth[1,2-b]thiirene." Journal of Heterocyclic Chemistry 37, no. 5 (2000): 1109–12. http://dx.doi.org/10.1002/jhet.5570370514.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Luo, Guanglin, Ling Chen, Charles M. Conway, et al. "Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine." Journal of Medicinal Chemistry 55, no. 23 (2012): 10644–51. http://dx.doi.org/10.1021/jm3013147.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Suman, Majumder, and L. Majumder P. "Catalytic aerobic oxidative transformation of the phenolic 9,10-dihydrophenanthropyran derivative imbricatin with CuCI(OH). TMEDA (TMEDA = N,N-tetramethylethylenediamine)." Journal of Indian Chemical Society Vol. 87, Dec 2010 (2010): 1539–46. https://doi.org/10.5281/zenodo.5805101.

Full text

Abstract:

Department of Chemistry, University College of Science, University of Calcutta, 92, Acharya Prafulla Chandra Road, Kolkata-700 009, India <em>E-mail:</em> priyalalmj@hotmail.com <em>Manuscript received 12 July 2010, accepted 16 August 2010</em> Treatment of imbricatin (2,7-dihydroxy-6-methoxy-9,10-dihydro-5<em>H</em>-phenanthro[4,5-<em>bcd</em>]pyran with CuCI(OH). TMEDA (TMEDA = <em>N,N</em>-tetramethylethylenediamine) in CH<sub>2</sub>CI<sub>2</sub> at 0-10 ºC for 20 h with stirring afforded four different compounds A, B, C and D in relatively low yields. The structures of A, B, C and D

APA, Harvard, Vancouver, ISO, and other styles

26

Nagalakshmi, R. A., J. Suresh, S. Maharani, R. Ranjith Kumar, and P. L. Nilantha Lakshman. "Crystal structures of 2-benzylamino-4-(4-bromophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile and 2-benzylamino-4-(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine-3-carbonitrile." Acta Crystallographica Section E Crystallographic Communications 71, no. 1 (2015): 12–15. http://dx.doi.org/10.1107/s2056989014025936.

Full text

Abstract:

In the title compounds, C24H22BrN3, (I), and C24H22ClN3, (II), the 2-aminopyridine ring is fused with a cycloheptane ring, which adopts a half-chair conformation. The planes of the phenyl and benzene rings are inclined to that of the central pyridine ring [r.m.s. deviations = 0.0083 (1) and 0.0093 (1) Å for (I) and (II), respectively] by 62.47 (17) and 72.51 (14)°, respectively, in (I), and by 71.44 (9) and 54.90 (8)°, respectively, in (II). The planes of the aromatic rings are inclined to one another by 53.82 (17)° in (I) and by 58.04 (9)° in (II). In the crystals of both (I) and (II), pairs

APA, Harvard, Vancouver, ISO, and other styles

27

Sharma, Omprakash, Shubham Srivastava, Manish Sharma, and Ruchi Malik. "Discovery of Benzoxazepines as a New Class of PIM1 Kinase Inhibitors Through Structure Based Virtual Screening, Biochemical Evaluation and Cytotoxicity Studies." ChemistrySelect 9, no. 12 (2024). http://dx.doi.org/10.1002/slct.202304650.

Full text

Abstract:

AbstractPIM kinase is a serine/threonine protein kinase implicated in human cancers because it promotes cell proliferation while inhibiting apoptosis and is a crucial target for malignancy. In the present study, we used 700000 commercially available Chembridge small molecules library for structure‐based drug discovery to identify novel potent PIM1 kinase inhibitors. Based on the virtual screening results, ten compounds were chosen and screened enzymatically at 10 μM. Out of ten compounds, only two compounds, 22876894 (61 %) and 58626268 (63 %), inhibited PIM1 kinase. Subsequently, the enzymati

APA, Harvard, Vancouver, ISO, and other styles

28

VEJDELEK, Z., and M. PROTIVA. "ChemInform Abstract: Potential Antidepressants and Tranquillizers: Synthesis of Some 9-(Aminoalkoxy)-2,3,6,7-tetrahydro-1H,5H-benzo(ij)quinolizines and 1-(Substituted Amino)-3-(1-naphthoxy)-2-propanols." ChemInform 21, no. 37 (1990). http://dx.doi.org/10.1002/chin.199037206.

Full text

APA, Harvard, Vancouver, ISO, and other styles

29

DEWALD, H. A., T. G. HEFFNER, J. C. JAEN, et al. "ChemInform Abstract: Synthesis and Dopamine Agonist Properties of (.+-.)-trans-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxa# zin-9-ol and Its Enantiomers." ChemInform 21, no. 22 (1990). http://dx.doi.org/10.1002/chin.199022205.

Full text

APA, Harvard, Vancouver, ISO, and other styles

30

Spellman, Michael, Safa Samimi, Ryan Kurtz, and Blythe Shepard. "Signaling of GPR17 in Hepatic and Renal Tissues." Physiology 39, S1 (2024). http://dx.doi.org/10.1152/physiol.2024.39.s1.1524.

Full text

Abstract:

G protein-coupled receptors (GPCRs) are the largest class of proteins in the human body and are considered to be excellent targets for drug discovery. However, the vast majority of GPCRs are understudied. Using a large-scale TaqMan array screen on both male and female C57BL6 murine livers, we identified GPR17 as one of the most highly expressed orphan receptors within the liver (ΔCt = 19.9, normalized to GAPDH). GPR17 expression in the liver was confirmed using reverse transcriptase polymerase chain reaction (RT-PCR) and was also identified in murine whole kidney from both males and females in

APA, Harvard, Vancouver, ISO, and other styles

31

DIJKSTRA, D., T. B. A. MULDER, H. ROLLEMA, P. G. TEPPER, J. VAN DER WEIDE, and A. S. HORN. "ChemInform Abstract: Synthesis and Pharmacology of trans-4-n-Propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano(4,3-b)-1,4-oxazin-7- and -9-ols: The Significance of Nitrogen pKa Values for Central Dopamine Receptor Activation." ChemInform 20, no. 20 (1989). http://dx.doi.org/10.1002/chin.198920212.

Full text

APA, Harvard, Vancouver, ISO, and other styles

32

Giwa, Muhammad Shehu, Basira Ibrahim, Fatima Musa, and Emad M. Abdallah. "Unveiling the Bioactive Phytochemicals of Momordica charantia Leaves and Their Antibacterial Effects." Journal of Medicinal Natural Products, October 16, 2024, 100006. https://doi.org/10.53941/jmnp.2024.100006.

Full text

Abstract:

Article Unveiling the Bioactive Phytochemicals of Momordica charantia Leaves and Their Antibacterial Effects Muhammad Shehu Giwa 1, Basira Ibrahim 1, Fatima Musa 1 and Emad M. Abdallah 2,3,* 1 Department of Biological Sciences, Faculty of Life Sciences, College of Science, Computing and Engineering, Kaduna State University, 800283 Kaduna, Nigeria 2 Department of Biology, College of Science, Qassim University, Qassim 51452, Saudi Arabia 3 Faculty of Health and Life Sciences, INTI International University, Persiaran Perdana BBN, Putra Nilai, 71800 Nilai, Negeri Sembilan, Malaysia. * Corresponden

APA, Harvard, Vancouver, ISO, and other styles

33

González, Gerardo García, and M. V. Basavanag Unnamatla. "9-(1H-Benzo[d]imidazol-2-yl)-2,3,6,7-tetrahydro-1H,5H-pyrido[3,2,1-ij]quinoline." IUCrData 2, no. 3 (2017). http://dx.doi.org/10.1107/s241431461700445x.

Full text

Abstract:

The title compound, C19H19N3, is a 2-heteroaryl benzimidazole derivative obtained through a straightforward and efficient protocol starting from julolidine-9-carbaldehyde and 1,2-phenylendiamine. The mean planes of the heterocyclic moieties in the molecule, benzimidazole and julolidine, form a dihedral angle of 40.9 (1)°. In the crystal, N—H...N hydrogen bonds link the imidazole rings, forming chains along the c-axis direction.

APA, Harvard, Vancouver, ISO, and other styles

34

Barreca, Marilia, Angela Maria Ingarra, Maria Valeria Raimondi, et al. "New tricyclic systems as photosensitizers towards triple negative breast cancer cells." Archives of Pharmacal Research, November 18, 2022. http://dx.doi.org/10.1007/s12272-022-01414-1.

Full text

Abstract:

AbstractNineteen pyrrolo[1,2-h][1,7]naphthyridinones and pyrido[2,3-c]pyrrolo[1,2-a]azepinones were synthesized as new tricyclic systems in which the pyridine ring is annelated to the 6,7-dihydroindolizin-8(5H)-one and 5,6,7,8-tetrahydro-9H-pyrrole[1,2-a]azepine-9-one moieties to obtain potential photosensitizing agents. They were tested for their photoantiproliferative activity on a triple-negative breast cancer cell line, MDA-MB-231, in the dark and under UVA light (2.0 J/cm2). We demonstrated that their toxicity, only when exposed to light, was primarily due to the generation of reactive ox

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!