Relevant bibliographies by topics / A Drugs

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'A Drugs'

Author: Grafiati
Published: 4 June 2021
Last updated: 12 February 2022

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Journal articles on the topic "A Drugs"

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Khanapure, Amol, Pem Chuki, and Avinash De Sousa. "Drug Repositioning : Old Drugs For New Indications." Indian Journal of Applied Research 4, no. 8 (October 1, 2011): 462–66. http://dx.doi.org/10.15373/2249555x/august2014/119.

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Bocharova, Inna Anatolevna, Vadim Agadzhanov, and Vadim Sagalaev. "Drug addiction. Drugs and their effects on man." Vestnik Volgogradskogo Gosudarstvennogo Universiteta. Serija 11. Estestvennye nauki, no. 2 (December 1, 2013): 22–27. http://dx.doi.org/10.15688/jvolsu11.2013.2.3.

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Isnenia, Isnenia. "Penggunaan Non-Steroid Antiinflamatory Drug dan Potensi Interaksi Obatnya Pada Pasien Muskuloskeletal." Pharmaceutical Journal of Indonesia 6, no. 1 (December 1, 2020): 47–55. http://dx.doi.org/10.21776/ub.pji.2020.006.01.8.

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The main therapy on musculoskeletal patients is the use of non-steroidal anti-inflammatory drugs (NSAIDs) either as monotherapy or in combination with drugs of the same class or pain relievers from other groups. The use of more than one drugs have potentially caused drug-drug interactions that can affect to patient. This study was aimed to describe the patient's sociodemographic (sex, ages) and clinical (numbers of drugs, type of drugs and diagnose) characteristics, as well as to find the correlation between potential drug interactions with these variables. This research was a quantitative study with a cross sectional design. Data were taken from 100 medical records of patients who had diagnosed with top five musculoskeletal diseases. Data were analyzed descriptively for sex, ages, number of drugs, type of drugs, and potential drug interactions. Bivariate correlation with chi-square were conducted to find statistically significancy potential drug interactions with each variable consist of sex, ages, type of drugs and it’s diagnose. The result shows that the musculoskeletal patients were 44% male, 56% female. Most musculoskeletal patients were aged 18-65 years (78%). Patients who received drugs <5 were 68% and ≥ 5 were 32%. 54% of patients were taking the diclofenac and only 5% of patients were taking the two NSAIDs combination, diclofenac and ibuprofen. There was no significant correlation (p > 0,05) between potential drug interactions with age, sex, type of NSAID, and type of musculosceletal diseases.
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Renner, Rebecca. "Drams of Drugs and Dregs." Scientific American 286, no. 5 (May 2002): 29. http://dx.doi.org/10.1038/scientificamerican0502-29.

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D, Subba Reddy, Prasanthi G, Amruth Raj S, Hari Krishna T, Sowjanya K, and Shantha Kumari K. "EVALUATION OF ANTICANCER GENERIC DRUGS AND BRANDED DRUGS." Indian Research Journal of Pharmacy and Science 5, no. 1 (March 2018): 1378–91. http://dx.doi.org/10.21276/irjps.2018.5.1.16.

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Singh, Uday, Gurjeet Singh, and Randhir Singh. "A STUDY ON DRUG UTILIZATION PATTERN OF ANTIHYPERTENSIVE DRUGS IN TERTIARY CARE HOSPITAL." INDIAN RESEARCH JOURNAL OF PHARMACY AND SCIENCE 7, no. 2 (June 2020): 2184–93. http://dx.doi.org/10.21276/irjps.2020.7.2.11.

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Chawra, Himmat Singh, Y. S. Tanwar, Ritu M. Gilhotra, and S. K. Singh. "Gastroretentive drug delivery systems a potential approach for antihypertensive drugs: An updated review." Asian Pacific Journal of Health Sciences 5, no. 2 (June 2018): 217–23. http://dx.doi.org/10.21276/apjhs.2018.5.2.40.

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Gillam, Tony. "Drugs or no drugs?" Nursing Standard 20, no. 23 (February 15, 2006): 26–27. http://dx.doi.org/10.7748/ns.20.23.26.s30.

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Gao, Shan, Anoliefo Ijeoma Janefrancis, Qingwei Cui, Yuqian Mi, Zhou Tong, and Bingxue Yan. "RNAi drugs: Next generation drugs?" Chinese Science Bulletin 65, no. 7 (March 1, 2020): 540–46. http://dx.doi.org/10.1360/tb-2019-0211.

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Andersen, T. "Are newer drugs better drugs?" Obesity Reviews 4, no. 2 (May 2003): 75. http://dx.doi.org/10.1046/j.1467-789x.2003.00097.x.

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Dissertations / Theses on the topic "A Drugs"

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Keesling, James Richard. "An evaluation of the drugs crime nexus, legalization of drugs, drug enforcement, and drug treatment rehabilitation." CSUSB ScholarWorks, 2000. https://scholarworks.lib.csusb.edu/etd-project/1697.

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Law enforcement agencies are faced with the problem of how to reduce crime in the most economical method possible without violating the law. Since drug offenders also engage in a disproportionate amount of non-drug crime, then drug enforcement is considered as an acceptable general crime control method. Unfortuantely, this is an expensive option because incarcerating offenders is both costly and ony a short-term solution to the problem. A review of existing research examining the prior criminal histories of drug offenders compared to their previous involvement in violent and property crime is conducted to evaluate this relationship.
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Osorio, Javier. "Hobbes on drugs| Understanding drug violence in Mexico." Thesis, University of Notre Dame, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3738644.

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This dissertation analyzes the unprecedented eruption of organized criminal violence in Mexico. To understand the dynamics of drug violence, this dissertation addresses three questions. What explains the onset of the war on drugs in Mexico? Once the conflict starts, why does drug violence escalate so rapidly? And lastly, why is there subnational variation in the concentration of violence?

Based on a game theoretic model, the central argument indicates that democratization erodes the peaceful configurations between the state and criminal organizations and motivates authorities to fight crime, thus triggering a wave of violence between the state and organized criminals and among rival criminal groups fighting to control strategic territories. In this account, state action is not neutral: law enforcement against a criminal group generates the opportunity for a rival criminal organization to invade its territory, thus leading to violent interactions among rival criminal groups. These dynamics of violence tend to concentrate in territories favorable for the reception, production and distribution of drugs. In this way, the disrupting effect of law enforcement unleashes a massive wave of violence of all-against-all resembling a Hobbesian state of war.

To test the observable implications of the theory, the empirical assessment relies on a novel database of geo-referenced daily event data at municipal level providing detailed information on who did what to whom, when and where in the Mexican war on drugs. This database covers all municipalities of the country between 2000 and 2010, thus comprising about 9.8 million observations. The creation of this fine-grained database required the development of Eventus ID, a novel software for automated coding of event data from text in Spanish. The statistical assessment relies on quasi-experimental identification strategies and time-series analysis to overcome problems of causal inference associated with analyzing the distinct - yet overlapping - processes of violence between government authorities and organized criminals and among rival criminal groups. In addition, the statistical analysis is complemented with insights from fieldwork and historical process tracing. Results provide strong support for the empirical implications derived from the theoretical model.

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Hernández, Yulán. "Drugs." Revista de Química, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/101299.

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Dossou-Yovo, Flore. "Modification de la biodisponibilité orale des médicaments : interactions « Herb-Drugs » « Drugs- Drugs»." Thesis, Paris, CNAM, 2014. http://www.theses.fr/2014CNAM0936/document.

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L’administration par voie orale des médicaments reste encore de nos jours la voie royale de la prise des médicaments car moins onéreuse et plus adaptée au confort du patient. Mais cette voie reste toujours inaccessible pour certains médicaments comme les médicaments biologiques et les bio similaires voir certains anticancéreux et antirétroviraux.Le but de ce travail est d’améliorer la biodisponibilité par voie orale des médicaments à faible biodisponibilité par la mise au point d’un promoteur d’absorption. Pour y arriver nous avons adopté comme stratégie de développer un promoteur qui agit à la fois sur le passage passif et sur le passage actif des médicaments. Les études in vitro ont été réalisées en chambre de perméation d’Ussing adaptées par la société Biomécatronics SAS (BéthuneFrance). Dans la première partie de ce travail (Brevet), nous avons montré que l’utilisation d’une composition pharmaceutique et/ou diététique comprenant un extrait de plante(Hibiscus sabdariffa) pouvait augmenter la biodisponibilité in vitro des médicaments et des xénobiotiques qui passent par la voie paracellulaire comme le cisplatine (21 fois),l’oxaliplatine (11fois), la fluorescéine isothiocyanate-Dextran 4000 (3 fois), mais également les médicaments connus pour leur transport actif par la voie transcellulaire comme l’Efavirenz (7 fois) et l’Atazanavir (4 fois). Dans la seconde partie de ce travail, nous avons cherché à vérifier si notre promoteur d’absorption des médicaments a un effet sur la couche de mucus intestinale.Cette couche peut être un facteur limitant de passage des médicaments au travers de la barrière intestinale.Dans un premier temps (article 1), nous avons induit l’augmentation de la couche mucus au niveau du colon de rat après un prétraitement pendant une semaine avec le métronidazole. Puis nous avions confirmé (article 2) que l’administration par voie orale de deux antibiotiques le Cotrimoxazole (CTX) et le métronidazole (MTZ) pendant une semaine augmente la couche de mucus au niveau du côlon ; aussi nous avons montré qu’il existe une relation entre l’augmentation de la couche de mucus et la diminution de la conductance qui est l’index de transport passif des ions, des électrolytes et de certaines molécules à faibles poids moléculaires.De plus l’augmentation de la couche de mucus au niveau de l’intestin est responsable de la diminution du passage transépithélial des deux antirétroviraux dont l’utilisation est recommandée en première ligne par l’OMS (le.Ritonavir et l’Atazanavir) surles sujets porteurs du VIH (virus de l’immunodéficience humain). Après les traitements auMTZ et au CTX la sécrétion de l’Atazanavir augmente respectivement dans le côlon proximal de 2 et 4 fois et dans le côlon distal de 3 et 5 fois. On obtient également une sécrétion du Ritonavir de 5 et 10 fois dans le proximal et de 2 et 5 fois plus dans le distal.Le travail se poursuit par l’étude de l’effet de notre promoteur d’absorption des médicaments sur la couche de mucus intestinal.En conclusion, ce travail montre que l’on peut augmenter la biodisponibilité in vitroen utilisant les promoteurs de l’absorption des xénobiotiques qui agissent à la fois au niveau du transport passif et actif
Oral dosing is still seen as the silver bullet of drug administration, as it is cheaper andbetter adapted to patient comfort. However, oral route is still inaccessible to many drugssuch as biologics and biosimilars respectively certain anticancer drugs and antiretrovirals(ARV).The aim of this present study was to find new drugs enhancers that improve the oralbioavailability of drugs and xenobiotics. All the studies were realized in vitro using Ussingchambers technic. To achieve the set objective we used the strategy to develop drugenhancer which can modulate at the same time transcellular and paracellular pathways.In the first part of this study (patent) we have shown that the use of a pharmaceutical and /or a dietetic formulation containing a plant extract (Hibiscus sabdariffa) could increase thebioavailability in vitro in rats not only of cisplatin (21 fold), oxaliplatin (11 fold) andFluorescein Isothiocyanate-Dextran 4000 (FD4, 3 fold). All that drugs were transportedthrough intestinal barrier using paracellular pathway. In addition the study showed thatthis formulated enhancer can increased the bioavailability of Efavirenz (7 fold) andAtazanavir (4 fold) which are active transported.In order to assess the effect of new drugs enhancer on mucus thickness that limits thetransport of xenobiotic through intestinal barrier, we decide to evaluate his effect on passiveand active transport of drugs.In the second part of this study we have shown that after a week of pre-treatment of ratswith Metronidazole (MTZ, publication 1) and Cotrimoxazole (CTX, publication 2), the twomost commonly used antibiotics in the prophylaxis against opportunistic infections in HIV /AIDS, both increase colonic mucus thickness that affect directly passive intestinalpermeability by reducing conductance an index of passive transport through intestinalepithelium. In addition those antibiotics also entail a change in the transepithelialconductance and ARV fluxes. After MTZ and CTX treatment the secretion of Atazanavir(ATZ) increases respectively in the proximal colon by 2 to 4 fold and in the distal colon by 3to 5 fold respectively. Ritonavir (RTV) is poorly absorbed in control, after a week of pretreatmentwith MTZ and CTX one rather notices a secretion of RTV 5 to 10 fold higher in theproximal and 2 to 5 fold higher in the distal colon. The next study will be conducted toevaluate the effect of new drugs enhancer on mucus thickness layer.In conclusion, oral bioavailability of drugs and xenobiotics can be enhanced bypharmaceutical composition that contains herbal extract which increase passive and activetransport of drugs through intestinal barrier
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Rosenbaum, Erik. "Optical characterization of potential drugs and drug delivery systems." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-40177.

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This Thesis is a characterization study on substances having potency as drugs as well as on a lipid based drug-delivery matrix. The optical properties of newly synthesized molecules with proven pilicide properties have been characterized with several spectroscopic methods. These methods include optical absorption and fluorescence as well as time-resolved fluorescence. Upon covalently linking compounds with high quantum yields of fluorescence to specific parts of the pilicide, the biological impact was found to increase for some of the derivatives. Furthermore, by expanding the aromatic part of the pilicide molecule, a significant increase in the inherent fluorescence was obtained. The S0-S1 absorption band for these molecules was found to originate from an impure electronic transition, vibronically promoted by intensity borrowing from higher electronic states. Included in this Thesis is the measurement of how deeply some in this class of newly synthesized molecules become situated when placed inside ganglioside GM1 micelles, and how the molecules’ reorientation is affected. By means of radiation-less energy transfer, it was shown that the molecules place themselves close to the hydrophobic-hydrophilic interface inside the GM1 micelles. As a consequence they are exposed to a densely packed environment, which inhibits the free tumbling of the molecule. This restricted tumbling could be measured by means of time-resolved depolarization experiments. The release of drug-like fluorescent molecules is investigated from a lipid mixture, which upon equilibrium with water forms a mixture of inverted hexagonal and cubic phases. The lipid matrix displayed an extended release over the course of weeks, in vitro, for molecules having a large variation in hydrophobicity.
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Attardo, Giorgio G. (Giorgio Giovanni). "Drug design and synthesis of novel heteroanthracycline antitumor drugs." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=74641.

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Novel heteroanthracycline antitumor drugs were designed based on structure activity relationship studies and known mechanisms of drug action. Their preparation required the development of a general synthetic approach.
After extensive studies, three methodologies were developed for the general synthetic plan. The first method involved photoenolisation of 2,5-dimethoxybenzaldehyde and SO$ sb2$ entrapment of the o-quinodimethane to give 4,7-dimethoxy-1-hydroxy-1,3-dihydrobenzo(2,3-c) thiophene-2,2-dioxide. This compound served as a general intermediate towards the synthesis of several heteroanthracyclinones. It could be reduced to the oxathiin-2-oxide derivative which thermally extruded SO$ sb2$ to yield the o-quinodimethane. Reentrapment of this latter intermediate with various glyoxalates gave key isochroman derivatives. The second method is an improvement over the first. Isochromandiones with a C-1 hydroxyl functionality were prepared from oxidative demethylation of 1-hydroxyisochromans. These were obtained after acid hydrolysis of the coupling products between epoxides and the cuprate of 2,5-dimethoxy-6-methylbenzaldehydedioxane acetal. The third method involved a sequential cycloaddition routine with two o-quinodimethanes.
By combining newly developed techniques with known methods, a general synthetic plan was developed. Consequently, the total synthesis of six tetracyclic structural hybrids of the naphthoquinone(2,3-c) pyranyl class of antibiotics was accomplished; along with the total synthesis of (R) and (S) 1-(4$ sp prime$-O-p-nitrobenzoyl-N-trifluoroacetyldaunosamine)-$ 1,3$-dihydrothioxantho(2,3-c) thiophene-2,2-dioxide, p-nitrobenzyl(5,12-dihydroxy-3,4-dihydrothioxantho(2,3-c) and (3,2-c) pyran-3-yl)formate, and eight novel heteroanthracyclines with the 5,12-dioxo-2,3,5,12-tetrahydroanthraceno(2,3-c) pyranyl backbone. The diastereomeric mixture of (1$ sp prime$S, 1R, 3S) and (1$ sp prime$S, 1S, 3R) methyl(11-hydroxy-1-$(2 sp prime,3 sp prime,6 sp prime $-trideoxy-3-trifluoroacetamido-L-lyxohexopyranose)-$5,12 $-dioxo-3,4,5,12-tetrahydroanthraceno(2,3-c) pyran-3-yl) formate was found to possess equipotent antileukemic activity to doxorubicin with no cross resistance.
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Hill, John C. "DRUMMING AWAY DRUGS: AN INNOVATIVE ALTERNATIVE TOWARDS DRUG REHABILITATION." UKnowledge, 2014. http://uknowledge.uky.edu/cld_etds/14.

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Drug use poses a serious threat to the quality of life for many Kentuckians and their families. Recent statistics indicate drug offenders account for a significant portion (in one year, 52,597 arrests were made for drug violations statewide) of individuals within thecriminal justice system, directly affecting the economic vitality within our state (Bunn & Slavova, 2012; Federal Bureau of Investigation, 2012). These statistics signify an overwhelming need for effective prevention efforts and innovative treatment alternatives. This study provides an innovative alternative treatment for drug offenders that infuses social and emotional coping strategies using percussion as a context. During the innovative program participants were able to express, recognize, articulate and evaluate themselves and their peers’ emotional coping strategies while developing peer camaraderie. They did so while being introduced to rudimentary drumming skills, fusing emotional intelligence with the art of drumming. The hypothesis is that this innovative program will enhance participant emotional intelligence to express, learn an effective coping skill, and establish camaraderie with their peers.
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Hemingway, Judith Frances Mary. "Spatializing drugs discourses : cultural geographies of illicit drug-using." Thesis, University College London (University of London), 2003. http://discovery.ucl.ac.uk/10020432/.

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Mohiddin, Syed Basha. "Development of novel unsupervised and supervised informatics methods for drug discovery applications." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1138385657.

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Nissen, Lisa Monique. "Quality use of medicines : from drug use evaluation to rural community pharmacy practice /." St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16549.pdf.

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Books on the topic "A Drugs"

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Ward, Brian. Drugs and drug abuse. London: Watts, 1987.

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Ward, Brian R. Drugs and drug abuse. London: F. Watts, 1987.

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Drugs, drug testing, and you. New York: Rosen Pub. Group, 1997.

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Ottenbrite, Raphael M., ed. Polymeric Drugs and Drug Administration. Washington, DC: American Chemical Society, 1994. http://dx.doi.org/10.1021/bk-1994-0545.

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Police, Illinois State. Drugs. Springfield, Ill.]: Illinois State Troopers, Dept. of State Police, 1986.

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Owen, Claire. Drugs. Cambridge: Independence, 2009.

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Levete, Sarah. Drugs. North Mankato, Minn: Stargazer Books, 2006.

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Drugs. Chicago, Ill: Heinemann Library, 2007.

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Joseph, Jennifer. Drugs. San Francisco, CA: Manic D Press, 1990.

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Dudley, William. Drugs. San Diego, Calif: Greenhaven Press, 2002.

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Book chapters on the topic "A Drugs"

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Harris, Howard A., and Henry C. Lee. "Drugs and drug analysis." In Introduction to Forensic Science and Criminalistics, 327–56. Second edition. | Boca Raton, FL : CRC Press, [2019] | Revised edition of : Introduction to forensics & criminalistics / Howard A. Harris, Henry Lee, c2008.: CRC Press, 2019. http://dx.doi.org/10.4324/9781315119175-13.

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Folkers, Gerd, Elvan Kut, and Martin Boyer. "Drug Design: Designer Drugs." In X.media.publishing, 53–63. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-69002-3_5.

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Barber, James G. "Drugs and Drug Addiction." In Social Work with Addictions, 1–25. London: Macmillan Education UK, 1995. http://dx.doi.org/10.1007/978-1-349-23805-7_1.

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De Castro, J., J. Meynadier, and M. Zenz. "Drugs." In Regional Opioid Analgesia, 131–209. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-009-2321-8_8.

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Szepietowski, Jacek C., and Adam Reich. "Drugs." In Pruritus, 195–204. London: Springer London, 2009. http://dx.doi.org/10.1007/978-1-84882-322-8_31.

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Law, Simon K. "Drugs." In Risk Prevention in Ophthalmology, 131–47. New York, NY: Springer New York, 2008. http://dx.doi.org/10.1007/978-0-387-73341-8_13.

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Broad, John. "Drugs." In Science and Criminal Detection, 15–32. London: Macmillan Education UK, 1988. http://dx.doi.org/10.1007/978-1-349-10604-2_2.

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Reith, Gerda. "Drugs." In Addictive Consumption, 79–102. Abingdon, Oxon ; New York, NY : Routledge, 2018.: Routledge, 2018. http://dx.doi.org/10.4324/9780429464447-7.

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Ksir, Charles. "Drugs." In Encyclopedia of Psychology, Vol. 3., 98–101. Washington: American Psychological Association, 2000. http://dx.doi.org/10.1037/10518-035.

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Stebbins, Michael. "Drugs." In Sex, Drugs and DNA, 240–73. New York: Palgrave Macmillan US, 2007. http://dx.doi.org/10.1007/978-0-230-55226-5_8.

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Conference papers on the topic "A Drugs"

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Suryakrishna, S. S., K. Praveen, S. Tamilselvan, and S. Srinath. "IoT Based Automation and Blockchain for Medical Drug Storage and Smart Drug Store." In Intelligent Computing and Technologies Conference. AIJR Publisher, 2021. http://dx.doi.org/10.21467/proceedings.115.8.

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The increase in the work stress and decrease in the time for oneself has led to the rise in the dependency on the medicines and drugs. The drugs and medicines are the key sources for saving the human life when the patient is in the danger. In order to maintain regular and quality supply of the drugs and medicines has to monitor on the regular basis. There are numerous medicines and drugs brought in the store but usually drugs and medicines are stolen to satisfy one’s greed, get expired or placed at unknown locations in the store. So to prevent such situation and saving the life of the patient Drug and Medicine Monitoring Model can be used. The model uses the RFID and IoT technology in order to monitor the drugs and medicines in the store. In medical and drug using systems which are increasing work stress and decreasing the time for oneself that has risen in dependency. The danger situation drugs and medicine is the main source for saving human life when the people are in danger. A daily regular basis to maintain a quality supply of the drug and medicine has been monitored. While traveling and transportation time is numerous medicines and drugs brought from the store but usually it is stolen to one’s greed and the medicines and drugs or placed at unknown locations. To prevent and save a patent life and monitoring model can be used to check the medicine and drug. In our model RFID tag and IoT technology can be used to monitor medicine and drug storage with the help of hospitals and how having a knowledge of the system and chemist of the medical and drugs available, the medicines and drugs quality of location and their safety.
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KOMARAGIRI, RAJESH. "Recycling of Drugs from Expired Drug Products." In 1st International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecmc-1-a003.

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KOMARAGIRI, RAJESH. "Recycling of Drugs from Expired Drug Products." In 1st International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a005.

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Kathawate, Jyoti, and Sumanta Acharya. "Computational Modeling of Intravitrael Drug Delivery in the Vitreous Chamber With Vitreous Substitutes." In ASME 2005 Summer Heat Transfer Conference collocated with the ASME 2005 Pacific Rim Technical Conference and Exhibition on Integration and Packaging of MEMS, NEMS, and Electronic Systems. ASMEDC, 2005. http://dx.doi.org/10.1115/ht2005-72783.

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Effective treatment of posterior segment diseases depends on the ability to deliver appropriate doses of drugs to target tissues in the posterior chamber of the eye. Intravitreal injection of drug is commonly used to treat vitreoretinal diseases. In order to assess the effectiveness of the injected drug, it is critical to know the drug distribution within the eye following injection. This is particularly important when the vitreous has been replaced by substitutes since there is little understanding of the transport of drugs in vitreous substitutes. The main objective of this research is therefore to characterize the drug distribution following intravitreal injection in the vitreous chamber of the human eye with different vitreous substitutes. In the present study, different intravitreal substitutes like silicone oil, fluorosilicone oil and perfluorocarbon liquids are considered. Both direct injection of drugs and injection of a time released drug distribution are studied. The results show that the concentration distribution is highly dependent on the vitreous substitute and the diffusion coefficient of the drug. For drugs with high diffusion coefficients, convection plays a small role. For drugs with low diffusion coefficients and for vitreous fluids with low viscosity, convection is seen to play a more important role.
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Celebi, Remzi, Vahab Mostafapour, Erkan Yasar, Ozgur Gumus, and Oguz Dikenelli. "Prediction of Drug-Drug Interactions Using Pharmacological Similarities of Drugs." In 2015 26th International Workshop on Database and Expert Systems Applications (DEXA). IEEE, 2015. http://dx.doi.org/10.1109/dexa.2015.23.

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Moshetova, L. K., M. M. Soshina, D. A. Sychev, and K. I. Turkina. "INTERACTION OF DRUGS IN OPHTHALMIC PRACTICE. ANTIGLAUCOMATOUS DRUGS." In XVII ВСЕРОССИЙСКАЯ ШКОЛА ОФТАЛЬМОЛОГА. ООО Бегемот-М, 2018. http://dx.doi.org/10.30808/978-5-6040782-2018-1-1-30-35.

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Khamenehfar, Avid, Ji Liu, Jia Cai, Michael Wong, Paul C. H. Li, Patrick Ling, and Pamela Russell. "Drug Accumulation Into Single Drug-Sensitive and Drug-Resistant Prostate Cancer Cells Conducted on the Single Cell Bioanalyzer." In ASME 2014 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2014. http://dx.doi.org/10.1115/imece2014-36166.

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Multidrug resistance (MDR) occurs in prostate cancer, and this happens when the cancer cells resist chemotherapeutic drugs by pumping them out of the cells. MDR inhibitors such as cyclosporin A (CsA) can stop the pumping and enhance the drugs accumulated in the cells. The cellular drug accumulation is monitored using a microfluidic chip mounted on a single cell bioanalyzer. This equipment has been developed to measure accumulation of drugs such as doxorubicin (DOX) and fluorescently labeled paclitaxel (PTX) in single prostate cancer cells. The inhibition of drug efflux on the same prostate cell was examined in drug-sensitive and drug-resistant cells. Accumulation of these drug molecules was not found in the MDR cells, PC-3 RX-DT2R cells. Enhanced drug accumulation was observed only after treating the MDR cell in the presence of 5 μM of CsA as the MDR inhibitor. We envision this monitoring of the accumulation of fluorescent molecules (drug or fluorescent molecules), if conducted on single patient cancer cells, can provide information for clinical monitoring of patients undergoing chemotherapy in the future.
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Choi, Jae Bong, Jamie Rogers, and Erick C. Jones. "The impact of a shared pharmaceutical supply chain model on counterfeit drugs, diverted drugs, and drug shortages." In 2015 Portland International Conference on Management of Engineering and Technology (PICMET). IEEE, 2015. http://dx.doi.org/10.1109/picmet.2015.7273165.

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Divetia, Asheesh, Nolan Yoshimura, Guann-Pynn Li, Baruch D. Kuppermann, and Mark Bachman. "Controlled and Programmable Drug Delivery Using a Self-Powered MEMS Device." In ASME 2007 2nd Frontiers in Biomedical Devices Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/biomed2007-38054.

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Controlled and targeted drug delivery systems have gained a lot of interest as they offer numerous benefits such as precise dosing, reduced side-effects and increased patient compliance. We have designed a microelectromechanical systems (MEMS) drug delivery device that is capable of releasing drugs in a controlled and programmable manner. This self-powered device does not require any external stimulation or control to achieve pulsatile release of drugs. The device consists of multiple reservoirs containing the drug embedded together with a water-swellable polymer. The swelling of the polymer upon contact with water and the resulting pressure generated is used as an actuation mechanism to release drugs from each reservoir. The programmable release of the drug from the device is achieved by controlling the diffusion rate of water from the surrounding environment into each reservoir. The drug is released from the reservoir when the swellable polymer absorbs water from the environment and generates enough pressure to break an overlying rupturable membrane. We have demonstrated that controlled and pulsatile drug delivery can be achieved using this delivery device, without any external power or control.
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Unterecker, S., M. Scherf-Clavel, S. Treiber, J. Deckert, and L. Hommers. "Drug-drug interactions between lithium and antihypertensive and anti-inflammatory drugs." In Abstracts of the 2nd Symposium of the Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) and Deutsche Gesellschaft für Biologische Psychiatrie (DGBP). Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3403006.

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Reports on the topic "A Drugs"

1

Lim, Peter. Analytical and Characterization Studies of Organic Chemicals, Drugs, and Drug Formulation. Fort Belvoir, VA: Defense Technical Information Center, November 2010. http://dx.doi.org/10.21236/ada536829.

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Lim, Peter. Analytical and Characteristics Studies of Organic Chemicals, Drugs, and Drug Formulations. Fort Belvoir, VA: Defense Technical Information Center, November 2012. http://dx.doi.org/10.21236/ada567567.

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Lim, Peter. Analytical and Characterization Studies of Organic Chemicals, Drugs and Drug Formulations. Fort Belvoir, VA: Defense Technical Information Center, October 2006. http://dx.doi.org/10.21236/ada466154.

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Lim, Peter. Analytical and Characterization Studies of Organic Chemicals, Drugs and Drug Formulations. Fort Belvoir, VA: Defense Technical Information Center, October 2005. http://dx.doi.org/10.21236/ada466189.

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Lim, Peter, and Lori Olson. Analytical and Characterization Studies of Organic Chemicals, Drugs and Drug Formulation. Fort Belvoir, VA: Defense Technical Information Center, July 1998. http://dx.doi.org/10.21236/ada352491.

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Lim, Peter. Analytical and Characterization Studies of Organic Chemicals, Drugs and Drug Formulation. Fort Belvoir, VA: Defense Technical Information Center, February 2004. http://dx.doi.org/10.21236/ada421361.

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Lim, Peter. Analytical and Characterization Studies of Organic Chemicals, Drugs, and Drug Formulation. Fort Belvoir, VA: Defense Technical Information Center, November 2011. http://dx.doi.org/10.21236/ada554000.

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Lim, Peter. Analytical, Characterization, and Stability Studies of Organic Chemical, Drugs, and Drug Formulation. Fort Belvoir, VA: Defense Technical Information Center, May 2014. http://dx.doi.org/10.21236/ada601351.

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Lim, Peter. Analytical, Characterization and Stability Studies of Chemicals, Bulk Drugs and Drug Formulations. Fort Belvoir, VA: Defense Technical Information Center, October 1997. http://dx.doi.org/10.21236/adb233658.

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Mehegan, Laura, and Laura Skufca. 2015 Survey on Prescription Drugs. AARP Research, April 2016. http://dx.doi.org/10.26419/res.00122.001.

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