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Journal articles on the topic 'A. K. Gopalan'

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Published: 18 May 2024

Last updated: 19 July 2025

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1

Larson, Helen K., Arumugam Murugan, Sivakumar Ragul, and Gopalan Mahadevan. "Resolution of the identity of the goby Glossogobius mas Hora, 1923 (Perciformes: Gobiidae) described from Chilka Lake, Odisha, India." Zootaxa 5213, no. 5 (2022): 596–600. https://doi.org/10.11646/zootaxa.5213.5.9.

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Larson, Helen K., Murugan, Arumugam, Ragul, Sivakumar, Mahadevan, Gopalan (2022): Resolution of the identity of the goby Glossogobius mas Hora, 1923 (Perciformes: Gobiidae) described from Chilka Lake, Odisha, India. Zootaxa 5213 (5): 596-600, DOI: 10.11646/zootaxa.5213.5.9

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Gopalan, K.R., and Vezhaventhan Dr.D. "Public Opinion onThe New Education Policy 2020." Journal for Educators, Teachers and Trainers 13, no. 1 (2022): 183–92. https://doi.org/10.47750/jett.2022.13.01.021.

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This study identifies education as a factor which manipulates the rural to urban migration observed in the particular areas of the city of Chennai, Madurai and Bangalore and need for the enactment of new education policy. The research was conceded in the same cities because the influence of education from rural-urban in some selected areas can be observed. It was carried out in Madurai, Chennai and Bangalore. Data was gathered by using online interview techniques so that correct and authentic information from the concerned people should be collected. The study reveals that education is the maj

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Jull, A. J. Timothy. "Principles of radiometric dating, by K. Gopalan. Cambridge, UK: Cambridge University Press, 2017, 224 p. $74.99. Hardback. Electronic copy will be available in future. $60.00. (ISBN 978-1-107-19873-9)." Meteoritics & Planetary Science 53, no. 5 (2018): 1108–9. http://dx.doi.org/10.1111/maps.13047.

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Li, Xuan C., Yuelin Liu, Farid Rashidi Mehrabadi, et al. "Abstract 127: Single-cell methylation sequencing data reveals succinct metastatic migration histories and tumor progression models." Cancer Research 83, no. 7_Supplement (2023): 127. http://dx.doi.org/10.1158/1538-7445.am2023-127.

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Abstract Recent studies exploring the impact of methylation in tumor evolution suggest that while the methylation status of many of the CpG sites are preserved across distinct lineages, others are altered as the cancer progresses. Since changes in methylation status of a CpG site may be retained in mitosis, they could be used to infer the progression history of a tumor via single-cell lineage tree reconstruction. In this work, we introduce the first principled distance-based computational method, Sgootr, for inferring a tumor's single-cell methylation lineage tree and jointly identifying linea

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Pfleiderer, Lisa-Maria, Christian Raschner, and Linda Rausch. "De-tabooing the menstrual cycle in sports – A qualitative approach." Current Issues in Sport Science (CISS) 9, no. 4 (2024): 048. http://dx.doi.org/10.36950/2024.4ciss048.

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Introduction Embarrassed and afraid to discomfort their – predominantly male – coach when talking about the menstrual cycle (MC), in elite sports populations 73-89% of female athletes avoided doing so, despite noticing an impact on training and performance (Solli et al., 2020; von Rosen et al., 2022). The aim of this study was to identify whether the topic of the MC in the context of sports is a persistent taboo and which measures could contribute to de-stigmatization. Methods The World Café method developed by Brown and Isaacs (2005), a qualitative research technique characterized by a creati

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Glen, David. "Integrated Pest Management in the Tropics: Current Status and Future Prospects. Edited by A. N. Mangech, K. N. Saxena and H. N. B. Gopalan. Chichester and New York: John Wiley (1995), pp. 171, £35.00. ISBN 0-1471-96076-4." Experimental Agriculture 33, no. 2 (1997): 247–52. http://dx.doi.org/10.1017/s0014479797220119.

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Khaled, Annette R., James Velazquez, Lam Truong, et al. "Abstract 2463: Protein folding chaperonin as biological indicator for cancer progression and metastasis." Cancer Research 83, no. 7_Supplement (2023): 2463. http://dx.doi.org/10.1158/1538-7445.am2023-2463.

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Abstract Protein folding complexes are a vital link between the expression of tumor-promoting oncogenes and oncogenic cancer behavior known as the hallmarks of cancer. Of these, the eukaryotic type II chaperonin, Chaperonin-Containing TCP-1 (CCT or TRiC) folds many of the oncoproteins (e.g., KRAS, MYC, CDKs, STAT3, etc.) that drive cancer growth and invasion. CCT is a complex machine composed of eight subunits, each encoded by a unique gene (cct1-8), which folds proteins in an ATP-dependent fashion within an inner chamber. Previous work in breast cancer revealed that the CCT2 subunit was highl

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Gudimalla, Prashanthi Kuntamalla Sujatha Akula Sampath Kaneez Fatima. "Phyto Essential Oils from Cymbopogon flexuosus and Lavendula officinales – Antibacterial Activity and Effect on Nutritional and Economic Traits of Mulberry Silkworm, B. Mori." Biolife 11, no. 2 (2023): 56–61. https://doi.org/10.5281/zenodo.7796017.

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<strong>Abstract</strong> The experiment evaluates the effect of two essential oils isolated from aromatic plants <em>Lavendula officinales </em>and<em> Cymbopogon flexuosus</em> against larval instars of silkworms by using fortification method. The tested essential oils had no adverse effect on larval growth or commercial characters of the silkworm except at higher concentrations. This experiment is part of doctoral work carried out during 2011 to 2014 and is one of the first attempt to understand the effect of the phyto essential oils at different concentrations on larval characters, nutriti

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Liu, Po-Tsun, Chih-Chieh Hsu, Shu-Wei Chang, and Yu Chuan Chiu. "(Invited) Study on Rram Properties Using Resistive Switching Layer with ZnO Nanostructure." ECS Meeting Abstracts MA2024-02, no. 34 (2024): 2419. https://doi.org/10.1149/ma2024-02342419mtgabs.

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Zinc oxide (ZnO) is an amorphous oxide semiconductor (AOS) material valued for its high carrier mobility, transparency to visible light, and low-temperature manufacturing process compared to silicon-based semiconductors. These desired features make ZnO-based AOSs widely popular as the channel layer in TFTs and as key dielectric layers in electronic devices like light sensors, gas detectors, resistive random-access memory (RRAM), and more. Among them, Conductive Bridge Random Access Memory (CBRAM) with a dielectric switching layer sandwiched between the electrochemically active metal (Ag, Cu) t

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Rahman, MA, R. Abka, MS Rahman, and PK Sarma. "Poverty and food security analysis: A study of fishermen households in a selected area of Bangladesh." Journal of the Bangladesh Agricultural University 11, no. 2 (2014): 293–300. http://dx.doi.org/10.3329/jbau.v11i2.19928.

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This study examines the poverty and food security analysis of fishermen households in a selected area of Gopalganj Sadar Upazila in Gopalganj District in Bangladesh. A sample size of 60 households was selected purposively from four villages. Data was collected through field survey by using pre-designed and pre-tested questionnaire. Calorie intake levels were calculated and statistical comparisons were done. Multiple regression analysis was carried out to determine the factor influencing calorie intake in individual levels. Food consumption scores were used to determine calorie intake levels. T

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Patel, Uma Devi, Vineeta Chandra, Milica Savatović, and Stojan Radenović. "On k-fuzzy metric spaces with applications." Nonlinear Analysis: Modelling and Control 30 (January 2, 2025): 1–22. https://doi.org/10.15388/namc.2025.30.38313.

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With application point of view, Gopal et al. [D. Gopal, W. Sintunavarat, A.S. Ranadive, S. Shukla, The investigation of k-fuzzy metric spaces with the first contraction principle in such spaces, Soft Comput., 27:11081–11089, 2023] generalized the conceptions of a fuzzy metric space and introduced the definition of k-fuzzy metric space. Here a fuzzy set defined in k-fuzzy metric space is a membership function FY : X × X × (0, +∞)k -> [0; 1], that is, the fuzzy distance between two points of the set depends on more than one parameter, and then also introduced first contraction principle in th

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Ng, Peter K. L., Hasko F. Nesemann, and Gopal Sharma. "A new freshwater species of Neorhynchoplax Sakai, 1938 (Crustacea: Decapoda: Hymenosomatidae) from Patna, Bihar, India." Zootaxa 3063 (December 31, 2011): 53–63. https://doi.org/10.5281/zenodo.204808.

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Ng, Peter K. L., Nesemann, Hasko F., Sharma, Gopal (2011): A new freshwater species of Neorhynchoplax Sakai, 1938 (Crustacea: Decapoda: Hymenosomatidae) from Patna, Bihar, India. Zootaxa 3063: 53-63, DOI: 10.5281/zenodo.204808

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J, Sudarvizhi. "Ethnographic Datas of Karisal Land in Gopalla Gramam Novel." International Research Journal of Tamil 4, S-4 (2022): 7–15. http://dx.doi.org/10.34256/irjt22s42.

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The intellectual anthropology that studies human beings examines human beings and human society at three levels: biological anthropology, social anthropology, and cultural anthropology. It is ethnography to trace the culture of a particular group of people in Tamilnadu, where different cultures and customs prevail. In that respect, the purpose of this study is to find ethnographic data in the novel Gopalla Gramam by the author K. Rajanarayanan, based on the biographies of the people of the Karisal area. In this study, the concepts like "what is ethnography? What are the cultural researchers' r

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Krishna, Gopal, K. Karthigeyan, W. Arisdason, and T. Chakrabarty. "A new species of Drypetes (Putranjivaceae/Euphorbiaceae s.l.) from West Bengal, India." Phytotaxa 319, no. 3 (2017): 271–76. https://doi.org/10.11646/phytotaxa.319.3.6.

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Krishna, Gopal, Karthigeyan, K., Arisdason, W., Chakrabarty, T. (2017): A new species of Drypetes (Putranjivaceae/Euphorbiaceae s.l.) from West Bengal, India. Phytotaxa 319 (3): 271-276, DOI: 10.11646/phytotaxa.319.3.6, URL: http://dx.doi.org/10.11646/phytotaxa.319.3.6

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Sharma, V., and N. Thakur. "Microwave Dielectric Study of Tetramethylurea andN, N-Dimethylacetamide Binary Mixture in Benzene." E-Journal of Chemistry 8, no. 3 (2011): 1378–86. http://dx.doi.org/10.1155/2011/329637.

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Dielectric relaxation of the binary mixture of tetramethylurea andN, N-dimethylacetamide has been studied at fixed frequency and temperature (9.88 GHz & 298 K respectively) in benzene solution. Different dielectric parameters like the dielectric constant (ε') and the dielectric loss (ε") at microwave frequency, static dielectric constant (ε0) and dielectric constant (ε∞) at optical frequency were determined. The values of relaxation time (τ(1), τ(2), τ(0)& τGK) have been calculated using higasi’s single frequency method and Gopala Krishna’s method. Using Eyring’s rate theory, the activ

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Mia, Sawrab, Mohammad Tanvir Ahmed Bulbul, Tamim Hasan, Mehedi Hasan Sheikh, and Md Tamjidul Haque. "MAXIMIZING CARROT PRODUCTIVITY: THE ROLE OF POTASSIUM AND BORON IN CROP PERFORMANCE." Tropical Agroecosystems 5, no. 1 (2024): 47–50. https://doi.org/10.26480/taec.01.2024.47.50.

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An experiment was conducted at the Bangabandhu Sheikh Mujibur Rahman Science and Technology University crop field, Gopalganj, to evaluate the effects of potassium and boron on the growth and yield of carrot (Daucus carota L.) from December 2022 to March 2023. The experiment included four doses of potassium (K): K0 (0 kg/ha, control), K1 (45 kg/ha), K2 (60 kg/ha), and K3 (75 kg/ha), and four doses of boron (B): B0 (0 kg/ha, control), B1 (0.5 kg/ha), B2 (1 kg/ha), and B3 (1.5 kg/ha). The two-factor experiment was arranged in a Randomized Complete Block Design (RCBD) with three replications. The

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Stallings, W. M. "Book Reviews : 100 Statistical Tests, by Gopal K. Kanji. Newbury Park, CA: Sage Publications, 1993, 216 pp." American Journal of Evaluation 16, no. 1 (1995): 81–83. http://dx.doi.org/10.1177/109821409501600112.

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Lis, Andrzej. "BOOK REVIEW: IN A TRIBUTE TO PROFESSOR GOPAL K. KANJI: THE EDITED COLLECTION "QUALITY, EXCELLENCE AND MEASUREMENT"." Journal of Positive Management 6, no. 1 (2015): 71. http://dx.doi.org/10.12775/jpm.2015.006.

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Colton, D. "100 Methods for Total Quality Management Gopal K. Kanji and Mike Asher. Newbury Park, CA: Sage, 1996,237 pp." American Journal of Evaluation 19, no. 2 (1998): 273–75. http://dx.doi.org/10.1016/s1098-2140(99)80210-0.

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Akshata., B. Kichadi, and Uma B. Gopal Dr. "A Review on Genetic Dominant Disorder Polydactyly." International Journal of Trend in Scientific Research and Development 3, no. 2 (2019): 258–60. https://doi.org/10.31142/ijtsrd20232.

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Polydactyly is genetic disorder in which there is mutation of gene that is located on short arm of chromosome 7. One gene that can cause polydactyly is GLI3 and it is one among number of genes that are known to be involved in the patterning of tissues and organs during development of the embryo. Mutations of GLI3 gene during development will cause two types of polydactyly. Those are postaxial ulnar and preaxial radial polydactyly. The treatment plan is based on the outcome of analysis of patient's medical history, social history, motivation, social and psychological disturbance. Akshata. B

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Gopal, K. Shyam, and Abdul Samim Ansari Mir. "Security Concerns in Cloud Computing." International Journal of Trend in Scientific Research and Development 2, no. 5 (2018): 2296–301. https://doi.org/10.31142/ijtsrd18306.

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Cloud computing is a revolutionary way of storing and accessing data with five essential characteristics, three service models, and four deployment models. Businesses have realized the tremendous potentiality and benefits of cloud computing and have accepted the technology, but still a small amount of scepticism hovers around. In defiance of its potential characteristics, the organizations risk their sensitive data by storing it in the cloud. In this paper, we have identified various privacy and security challenges associated with the novelty of cloud computing. The security and privacy challe

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Padmanand, V. "Book Reviews : Gopal K. Kanji and Mike Asher, 100 Methodsfor Total Quality Manage ment, New Delhi: Response Books, 1996, pp. 237." Journal of Entrepreneurship 6, no. 2 (1997): 260–62. http://dx.doi.org/10.1177/097135579700600212.

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Tango, Toshiro. "100 Statistical Tests. Gopal K. Kanji, Sage Publications, London, 1999. No. of pages: 215. Price: £49.50. ISBN 0-7619-6151-8." Statistics in Medicine 19, no. 21 (2000): 3018. http://dx.doi.org/10.1002/1097-0258(20001115)19:21<3018::aid-sim594>3.0.co;2-u.

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Manu, Krishnan. K., and B. Gopal Uma. "Bifid Xiphoid Process A Case Report." International Journal of Trend in Scientific Research and Development 3, no. 2 (2019): 444–45. https://doi.org/10.31142/ijtsrd21397.

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The sternum is a flat bone forming the anterior median part of the thoracic skeleton. Xiphoid process is the smallest part of the sternum. It is at first cartilaginous, but in adult it becomes ossified near its upper end. It varies greatly in its morphology and lies in the floor of epigastric fossa. A bifid xiphoid process was observed during routine cadaveric dissection of the pectoral region, which was seen as an everted bulging mass in the epigastric pit between the two costal margins. There is a need for awareness of these findings as they may determine the accuracy of clinical and other p

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Sridhara, R. "Book reviews : Gopal K Kanji 1993: 100 Statistical tests. Newbury Park, CA: Sage Publications. 216pp. $21.95 (PB). ISBN 0 8039 8705 6." Statistical Methods in Medical Research 4, no. 3 (1995): 269. http://dx.doi.org/10.1177/096228029500400311.

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Shahrin, F., P. Roy, M. S. Raihan, M. M. Haque, and M. G. Rasul. "GENETIC VARIABILITY FOR GRAIN NUTRIENTS CONTENT IN COASTAL RICE COLLECTIONS OF BANGLADESH." International Journal of Research -GRANTHAALAYAH 9, no. 11 (2021): 182–201. http://dx.doi.org/10.29121/granthaalayah.v9.i11.2021.4400.

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Overcoming malnutrition through biofortification breeding in rice is aimed to assist nutritional food security in Bangladesh. So to select parents for nutritional improvement, estimation and exploitation of mineral nutrients reserves of rice grain and their variability assessment in different genotypes is essential. Eighty-five (85) T. aman rice genotypes collected from different coastal regions of Bangladesh were evaluated at the Advanced Plant Breeding laboratory, GPB of BSMRAU to estimate the grain nutrients content and to elucidate their genetic variability among the genotypes. Considerabl

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Yamuna, P., and K. Venu Gopal B. "FPGA Based Hybrid LMS Algorithm Design on Distributed Arithmetic." International Journal of Trend in Scientific Research and Development 3, no. 1 (2018): 558–63. https://doi.org/10.31142/ijtsrd19018.

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Filter plays a major role for removal of unwanted signal noise from the original signal, especially Adaptive FIR filter is easy to attract for many applications, where it is need to minimize computational requirement. This paper shows a novel pipelined design for low power, high throughput, and low area implementation of adaptive lter based on distributed arithmetic DA . The DA formulation utilized for two separate blocks weight update block and filtering operations requires larger area and is n't suited for higher order filters therefore causes reduction in the throughput. These issues ha

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Edgeman, Rick L. "Fundamentals of Total Quality Management3Jens J. Dahlgaard, Kai Kristensen, Gopal K. Kanji. Fundamentals of Total Quality Management. London, UK: Chapman & Hall Publishers 1998. 372 pp." TQM Magazine 10, no. 4 (1998): 312. http://dx.doi.org/10.1108/tqmm.1998.10.4.312.3.

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Parveen, S., MA Ali, and MA Ali. "Screening Rice Germplasm against Sheath Blight Disease of Rice and its Integrated Management in Bangladesh." Bangladesh Rice Journal 22, no. 2 (2019): 1–12. http://dx.doi.org/10.3329/brj.v22i2.44047.

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Fifty-seven rice germplasm collected from BRRI Genebank were screened against sheath blight (ShB) by artificial inoculation in field and laboratory conditions in T. Aman 2012. Significant differences on relation to lesion height (RLH) among the germplasm were observed, where the highest (83%) was recorded in susceptible check, BR11 and the lowest (8.33%) was in Orgoja. Severity score of ShB was recorded maximum (9) in Dudhsail, Basi, Chaula mari, Holdemota, Calendamota, Semmua, Kotijira, Halisail, Horakani, Kalisura, Ashfuli, Huglapata and BR11 as highly susceptible to ShB, whereas it was mini

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Rao, MS Rama, Vinod Agrawal, Kanupriya Dhingra, V. Rajesh Gopal, and Abhijita Mohapatra. "An in vitro comparison of Antimicrobial Efficacy of Three Root Canal Irrigants—BioPure MTAD, 2% Chlorhexidine Gluconate and 5.25% Sodium Hypochlorite as a Final Rinse against E. faecalis." Journal of Contemporary Dental Practice 14, no. 5 (2013): 842–47. http://dx.doi.org/10.5005/jp-journals-10024-1413.

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ABSTRACT Aim This study was conducted to evaluate the antimicrobial activity of 5.25% sodium hypochlorite (NaOCl), 2% chlorhexidine (CHX) and BioPure MTAD when used as a final rinse against Enterococcus faecalis. Materials and methods Sixty single-rooted premolars were biomechanically prepared, inoculated with E. faecalis and divided into various groups. These were then irrigated with the test irrigants and tested microbiologically for growth of E. faecalis immediately after irrigation and after 48 hours. Results Statistical analysis showed that there was a significant difference between the a

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Larson, Karl, Basila Kattouf, Delina Damatov, Assaf Y. Anderson, and Paul Albertus. "Defining an Ontology for All Solid-State Battery Cells for Database Implementation." ECS Meeting Abstracts MA2023-02, no. 4 (2023): 563. http://dx.doi.org/10.1149/ma2023-024563mtgabs.

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New developments and publications on in alkali metal solid-state batteries appear regularly, with the number of publications now numbering in the hundreds to low thousands, but the search and analysis of the data contained in these publications is still largely done by manually reading through each article. Such challenges are also present in other fields, such as perovskite solar cells, for which successful efforts to create a database have been pursued. Review articles can provide valuable summaries and insights on groupings of these publications, but the rapid rate of development and the “s

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Aparna, G. S., K. Gopal, K. Venkata Subbaiah, M. N. Reddy, and M. Sreenivasulu. "First Report of Herbacious Hosts for Citrus yellow mosaic badna virus from India." Plant Disease 86, no. 8 (2002): 920. http://dx.doi.org/10.1094/pdis.2002.86.8.920a.

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Citrus mosaic disease, a potential threat to citrus production throughout India, is currently an important disease in the southern and northeastern states (2). The reported incidence of the disease ranges from 10 to 77% (K. Gopal, G. S. Aparna, M. Sreenivasuluk, K. V. Subbaiah, and A. R. K. Rao, unpublished data). This yellow mosaic disease of citrus is caused by Citrus yellow mosaic badna virus (CMBV), formerly citrus yellow mosaic disease, (CYMD) (1). Host range studies were done to find herbaceous noncitrus host plant species for virus maintenance. The following are the noncitrus plants tes

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Smith, Kandler. "(Invited) Accelerating Battery R&D from Materials-to-Device Using AI and Data." ECS Meeting Abstracts MA2024-02, no. 3 (2024): 347. https://doi.org/10.1149/ma2024-023347mtgabs.

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Data-driven research promises to accelerate the development of novel electrochemical energy storage technologies. Atomistic- to materials-scale efforts include discovery and synthesis through autonomous “self-driving” laboratories [1,2]. Here, we present several continuum-scale efforts where a complete electrochemical couple is tested at length scales ranging from coin cell (laboratory) to complete system (field) and linked with physics-based AI algorithms to compress development time. We highlight successes and challenges transferring learning across chemistries, designs [3], and operating co

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Amarnath., K., Gopal. P. Dr., M. Sridharan., and T. Senthil Kumar Dr. "Performance Improvement Analysis and Simulation of Solar PV T Water Collector." International Journal of Trend in Scientific Research and Development 2, no. 4 (2018): 960–65. https://doi.org/10.31142/ijtsrd14201.

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The objective of this paper is to review the collection of literature available on the Photo Voltaic and Thermal Solar Collector. The review paper is presented to show the comparison of findings obtained by various research works. In solar collector, the solar energy from the sun is converted in to electrical energy by means of Photo Voltaic panel and thermal energy by converting cold water into hot water. Nowadays, solar collector is preferred in many industries and house hold applications to reduce the demand of electricity by increasing the effective utilization of solar energy coming from

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Pratap, Uday, Khaled Mohamed Nassar, Xue Yang, et al. "Abstract 3172: Significance of PELP1 signaling in liver cancer progression." Cancer Research 84, no. 6_Supplement (2024): 3172. http://dx.doi.org/10.1158/1538-7445.am2024-3172.

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Abstract Background: Hepatocellular carcinoma (HCC) is the fastest-rising cause of cancer-related mortality in the United States. Furthermore, advanced HCC has a very poor prognosis, with a median survival time of only about ten months. Effective new targeted therapies are urgently needed for the treatment of HCC. Proline, glutamic acid-, and leucine-rich protein 1 (PELP1) is a protooncogene. PELP1 signaling has been implicated in the development of several cancers, however, its role in the progression of HCC remains unclear. The goal of this project is to investigate the significance and ther

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Fuentes, Zenaida, Rahul Gopalam, Bianca A. Romo, et al. "Abstract 2100: Novel LIPA targeted therapy for treating inflammatory breast cancer." Cancer Research 84, no. 6_Supplement (2024): 2100. http://dx.doi.org/10.1158/1538-7445.am2024-2100.

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Abstract Background: Inflammatory breast cancer (IBC) is a rare but incredibly aggressive subtype of breast cancer (BC). IBC accounts for 2-4% of all occurrences of breast cancer and results in 7-10% of breast cancer-related deaths. IBC is only partially treatable with current therapies such as chemotherapy, surgery, and radiotherapy. Identification of novel therapeutic targets is urgently required. The main organelle for the synthesis, folding, and modification of proteins is called the endoplasmic reticulum (ER). Since elevated basal ER stress (ERS) is usually found in many cancers including

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Viswanadhapalli, Suryavathi, Tae-Kyung Lee, Scott Elmore, et al. "Abstract 394: Preclinical evaluation of ERX-208, a potent inducer of ER stress for the treatment of ovarian cancer." Cancer Research 84, no. 6_Supplement (2024): 394. http://dx.doi.org/10.1158/1538-7445.am2024-394.

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Abstract Background: Ovarian cancer (OCa) is the deadliest kind of gynecologic cancer in the United States. The long-term survival rate for OCa is less than 20% after five years. Intra-tumoral and inter-tumoral heterogeneity is implicated in tumor resistance to conventional therapies and the unsatisfactory clinical outcomes. Addressing these issues necessitates innovative therapies that target intrinsic common vulnerabilities within OCa. Recent studies have highlighted that high basal level of endoplasmic reticulum stress (ERS) in OCa as a critical vulnerability. We have identified a promising

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Gopal, Ajay K., Ted Gooley, Joseph Rajendran, et al. "A Phase I Study of Myeloablative I-131-Anti CD-20 (Tositumomab) Radioimmunotherapy with Escalating Doses of Fludarabine Followed by Autologous Hematopoietic Stem Cell Transplantation (ASCT) for Adults ≥ 60 Years of Age with High-Risk or Relapsed/Refractory B-Cell Lymphoma." Blood 118, no. 21 (2011): 663. http://dx.doi.org/10.1182/blood.v118.21.663.663.

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Abstract Abstract 663 Background: The majority of patients with relapsed or refractory B-cell, non-Hodgkin's lymphoma (NHL) are over 60 years of age, yet many are denied potentially curative high-dose regimens due to concerns of excessive toxicity. We have shown that myeloablative anti-CD20 radioimmunotherapy (RIT) can safely deliver effective radiation doses to tumor sites while limiting exposure to normal organs in older adults requiring high-dose therapy, however, not all patients in this series remained progression-free (Gopal, JCO 2007). Preclinical data suggest that improved anti-tumor a

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V., Pushpa Rani, and Amila Meera K. "Phytochemical analysis & in-vitro cytogenetics assay of chromosomal aberration on peripheral human blood lymphocytes by the leaf crude extract- Passiflora foetida L." Biolife 3, no. 1 (2022): 154–63. https://doi.org/10.5281/zenodo.7252025.

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<strong>ABSTRACT</strong> The present investigation is to evaluate the analysis preliminary photochemical screening and <em>In-vitro</em> cytogenetic assay measuring chromosomal aberration frequencies induced by the leaf crude extract <em>Passiflora  foetida L.</em> as an active ingredient in peripheral human blood lymphocyte. Whole blood lymphocytes were cultured <em>in-vitro</em> using a standard protocol and the treatment with the leaf crude extract. The plant extract and fractions revealed preliminary phytochemical compounds with no toxicity. The present investigation revealed that no

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Runa, Rashmi, and M.P.Trivedi Dr. "Fast In-Vitro Regeneration of an Important Medicinal Plant Karaveera (Nerium odorum L.)." Biolife 4, no. 2 (2022): 275–84. https://doi.org/10.5281/zenodo.7317740.

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  <strong>ABSTRACT</strong> <em>Nerium odorum</em>, <em>Linn</em>. (Apocynaceae) an important evergreen shrub which is heat, salinity, and drought tolerant.  Plants with milky sap has medicinal value, mainly cardenolides, flavonoids, and terpenes. It comprises of total 01 species. Explants of an alkaloid producing plant cultured <em>in vitro</em> and has been found to retain the capacity to synthesis alkaloids identical to that in the intact plant. It is used for wastewater purification and for restoration of riparian woodlands. In view of these facts the study was conducted for micr

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Ebrahimi, Behnam, Suryavathi Viswanadhapalli, Uday P. Pratap, et al. "Abstract 5998: Pharmacological inhibition of the LIF-LIFR autocrine loop reveals vulnerability of ovarian cancer to ferroptosis." Cancer Research 84, no. 6_Supplement (2024): 5998. http://dx.doi.org/10.1158/1538-7445.am2024-5998.

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Abstract Introduction: Of all gynecologic cancers, epithelial ovarian cancer (OCa) stands out with the highest mortality rates. Despite all efforts, 90% of individuals who receive standard surgical and cytotoxic therapy experience disease recurrence. The potential involvement of leukemia inhibitory factor (LIF) and its receptor (LIFR) in the progression of OCa is still obscure. In this study, we examined the mechanisms by which disruption of LIF/LIFR autocrine loops contributes to the cell death of ovarian cancer cells. Methods: The expression profiles of LIF and LIFR were obtained using 24 di

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Ebrahimi, Behnam, Suryavathi Viswanadhapalli, Uday P. Pratap, et al. "Abstract 4966: Targeting LIF/LIFR autocrine loops with EC359 in ovarian cancer: A novel LIFR targeted therapy." Cancer Research 83, no. 7_Supplement (2023): 4966. http://dx.doi.org/10.1158/1538-7445.am2023-4966.

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Abstract Background: Of all gynecologic cancers, ovarian cancer (OCa) has the highest mortality rates. Nearly 90% of patients who receive standard surgical and cytotoxic treatment experience disease recurrence. Leukemia inhibitory factor (LIF) and its receptor LIFR are implicated in the progression of several cancers. A knowledge gap exists on whether LIF/LIFR plays a role in the evolution of OCa. We recently developed EC359, a first-in-class LIFR inhibitor. Here, we examined whether autocrine loops of LIF/LIFR contribute to OCa progression and tested the utility of EC359 as a potential target

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Gilden, Julia K., Christopher Eggers, Yitong Li, et al. "Abstract 5486: Bioluminescent assays for antibody-drug conjugate development: internalization and Fc-mediated functions." Cancer Research 85, no. 8_Supplement_1 (2025): 5486. https://doi.org/10.1158/1538-7445.am2025-5486.

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Abstract Antibody-drug conjugates (ADCs) combine targeted delivery with potent cytotoxic payloads, utilizing multiple mechanisms of action (MoA). These include direct cytotoxicity following internalization of the ADC by antigen-expressing cells, killing of bystander cells through cleaved payloads, antigen function blockade, and immune-mediated cytotoxicity (e.g. Antibody-Dependent Cellular Cytotoxicity and Antibody-Dependent Cellular Phagocytosis) driven by the antibody Fc region. Comprehensive characterization and potency testing of ADCs require assays that capture each MoA. To address this n

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Sateesh, Pujari, and Mamidala Estari. "Anti-diabetic activity of Physagulin-F isolated from Physalis angulata fruits." AMERICAL JOURNAL OF SCIENCE AND MEDICAL RESEARCH 1, no. 2 (2015): 53–60. https://doi.org/10.5281/zenodo.7352308.

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<strong>Abstract</strong> Type 2 diabetes is a chronic medical condition that requires regular monitoring and treatment throughout your life. Natural compounds from plant sources have been extensively used as traditional medicines from centuries.  The present study was carried out to isolate and identify the putative antidiabetic compound from the Physalis angulata (PA) fruit. A compound, Physagulin-F was isolated from PA fruit extract. The isolated compound Physagulin-F (100, 300 and 500 mg/kg) of Physalis angulata fruit was undertaken to evaluate the anti-diabetic activity against strep

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Collier, Alexia B., Suryavathi Viswanadhapalli, Tae-Kyung Lee, et al. "Abstract 3986: Novel LIPA targeted therapy for treating ovarian cancer." Cancer Research 83, no. 7_Supplement (2023): 3986. http://dx.doi.org/10.1158/1538-7445.am2023-3986.

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Abstract BACKGROUND: Ovarian cancer (OCa) is the deadliest of all gynecologic cancers in the United States. Currently approved therapies have improved OCa survival for clinically localized disease, however, the majority (~90%) of patients with high-grade serous OCa (HGSOC) experience relapse with incurable metastases. There is a dire need for new therapeutic approaches. We hypothesized that the high basal endoplasmic reticulum stress (ERS) in OCa represents a critical and targetable vulnerability and may overcome the tumor heterogeneity. The objective of this project is to exploit increased ER

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Viswanadhapalli, Suryavathi, Tae-Kyung Lee, Kara Kassees, et al. "Abstract 4813: ERX-208 as a novel therapeutic for treating ovarian cancer by enhancing endoplasmic reticulum stress." Cancer Research 83, no. 7_Supplement (2023): 4813. http://dx.doi.org/10.1158/1538-7445.am2023-4813.

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Abstract Background: Ovarian cancer (OCa) is the deadliest of all gynecologic cancers in the United States. Despite initial response to chemotherapy, most OCa patients become chemo resistant and progress to metastatic disease. Here, we tested the hypothesis that the high basal level of endoplasmic reticulum stress (ERS) in OCa represents a critical vulnerability and drugs that further aggravate this already engaged system in OCa may exhaust its protective features and contribute to apoptosis induction. The objective of this proposal is to identify a hit compound that enhances ERS in OCa and to

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Viswanadhapalli, Suryavathi, Tae-Kyung Lee, Kara Kassees, et al. "Abstract 3756: Optimization of the LIPA targeting agent for the treatment of ovarian cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 3756. https://doi.org/10.1158/1538-7445.am2025-3756.

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Abstract Background: Ovarian cancer (OCa) is the most lethal form of gynecologic cancer in the United States, with a five-year survival rate below 20%. Tumor resistance to chemotherapy and poor clinical outcomes are driven by intratumoral and intertumoral heterogeneity. There is a critical need for novel therapies to overcome these challenges. Recent findings indicate that elevated basal levels of endoplasmic reticulum stress (ERS) in OCa represent a significant vulnerability and identified LIPA as a novel target for inducing ERS in cancer cells with the oligobenzamide ERX-41. In this study, w

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Wee, Yinshen, Junhua Wang, Emily C. Wilson, et al. "Abstract 3926: ARF6-dependent endocytic trafficking of the interferon-gamma receptor drives adaptive immune resistance and response to immune checkpoint blockade." Cancer Research 84, no. 6_Supplement (2024): 3926. http://dx.doi.org/10.1158/1538-7445.am2024-3926.

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Abstract Interferon-gamma (IFNγ)-driven adaptive immune resistance (AIR) in cancer begins at the plasma membrane where cytokine signaling is initiated. Cytotoxic CD8+ T cells secrete IFNγ, eliciting tumor-intrinsic IFNγ signaling and expression of immunosuppressive genes, which are critical for effective therapeutic response to anti-PD-1 and anti-CTLA-4 immune checkpoint blockade (ICB). Although the IFNγ receptor (IFNγR) is expressed in all cell types, its surface density can determine a cell’s responsiveness to ligand. Mechanistic control over this process remains a mystery. Herein we report

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Odelu, G. "PRESENT STATUS OF AQUATIC MACROPHYTES OF FOUR FRESH WATER ECOSYSTEMS OF ELLANDHAKUTA AND ITS SURROUDING VILLAGES, KARIM NAGAR DISTRICT, TELANGANA. INDIA." Biolife 2, no. 3 (2022): 956–65. https://doi.org/10.5281/zenodo.7224935.

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<strong>ABSTRACT</strong> Present study was conducted on four fresh water ecosystems to analyses,the importance of fresh ecosystems biological components, species diversity, alienspecies, aquatic macrophytes distribution in four  villages around study area was studied during 2012-2014. One hundred and ten different species of were recorded in 41 families in these 24 from Dicotyledons, 14, Monocots, two from Pteridophyta, one from Algae total Genera 84. Poaceae was the most dominant families with 14 species followed by Cyperaceae (10species), Asteraceae(9), Euphorbhiaceae (7), an

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Lee, Hyunjung, Gopal K. Singh, Ahmedin Jemal, and Farhad Islami. "Abstract 1927: Differential effects of social isolation on cancer mortality by race/ethnicity and socioeconomic status among working age adults in the United States." Cancer Research 83, no. 7_Supplement (2023): 1927. http://dx.doi.org/10.1158/1538-7445.am2023-1927.

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Abstract Background Social isolation or living alone can negatively affect mental health, sleep quality, eating behavior, immunity, proinflammatory response to stress, and receipt of care in cancer patients (e.g., assistance with nutrition and mobility, emotional and informational support), which may increase the risk of death from cancer. Previous studies, however, have shown inconsistent findings on the association between social isolation and cancer mortality. To address the literature gap, we examined this association among working-age adults stratified by sociodemographic characteristics

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