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1

Percival, Benita C., Martin Grootveld, Miles Gibson, et al. "Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models." High-Throughput 8, no. 1 (2018): 2. http://dx.doi.org/10.3390/ht8010002.

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Novel sensing technologies for liquid biopsies offer promising prospects for the early detection of metabolic conditions through omics techniques. Indeed, high-field nuclear magnetic resonance (NMR) facilities are routinely used for metabolomics investigations on a range of biofluids in order to rapidly recognise unusual metabolic patterns in patients suffering from a range of diseases. However, these techniques are restricted by the prohibitively large size and cost of such facilities, suggesting a possible role for smaller, low-field NMR instruments in biofluid analysis. Herein we describe s
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Dr., K. Pazhanivel Dr. Priya Ramani Dr. Illakhiya V.* Dr. K. Jelin Lilly Dr. A. Joshua. "Saliva – A Diagnostic Tool for Oral Cancer and Oral Diseases- A Review." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1334–43. https://doi.org/10.5281/zenodo.14221670.

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Saliva, a readily accessible biofluid, has emerged as a promising diagnostic tool for various oral diseases and systemic conditions. Its non-invasive nature and the presence of numerous biomarkers make it ideal for early detection, monitoring disease progression, and informing treatment decisions. This review gives an overview into the potential of salivary diagnostics in oral cancer, dental caries, periodontal diseases, Sjogren's syndrome, oral lichen planus, oral leukoplakia, and systemic diseases like cardiovascular diseases, diabetes, and viral infections. The article discusses the factors
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Han, HL, CY Lee, Y. Shoji, and HT Chin. "Detection of Metabolomic Profile of Saliva in Healthy Malaysian Adults." Compendium of Oral Science 2, no. 1 (2015): 40–46. http://dx.doi.org/10.24191/cos.v2i0.17525.

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Background: Saliva is a readily accessible biofluid that is important for the overall quality of life, functionally essential in the chewing, swallowing, tasting, regulation mouth flora and prevention of caries. The aim of this study is to assess the global metabolomic profile of saliva in healthy Malaysian adults. Methods: As a first step to determining and understanding the metabolomic profile of saliva in healthy Malaysian adults, we have collected saliva samples of 50 adults and measured the salivary metabolite to establish a profiling metabolite data, Human Metabolome Database (HMDB). Met
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Gómez, Cristina, Carolina Gonzalez-Riano, Coral Barbas, et al. "Quantitative metabolic profiling of urinary eicosanoids for clinical phenotyping." Journal of Lipid Research 60, no. 6 (2019): 1164–73. http://dx.doi.org/10.1194/jlr.d090571.

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The eicosanoids are a family of lipid mediators of pain and inflammation involved in multiple pathologies, including asthma, hypertension, cancer, atherosclerosis, and neurodegenerative diseases. These signaling mediators act locally, but are rapidly metabolized and transported to the systemic circulation as a mixture of primary and secondary metabolites. Accordingly, urine has become a useful readily accessible biofluid for monitoring the endogenous synthesis of these molecules. Herein, we present the validation of a rapid, repeatable, and precise method for the extraction and quantification
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Calixto, Patricia Sthefani, Fernanda Cereda Ferraz, Gabriela Carolina Dutra, et al. "Exploring Saliva as a Sample for Non-Invasive Glycemic Monitoring in Diabetes: A Scoping Review." Biomedicines 13, no. 3 (2025): 713. https://doi.org/10.3390/biomedicines13030713.

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Background/Objectives: Diabetes mellitus is characterized by a dysregulated glucose metabolism, necessitating frequent and often invasive monitoring techniques for its effective management. Saliva, a non-invasive and readily accessible biofluid, has been proposed as a potential alternative for glycemic monitoring due to its biochemical correlation with blood glucose levels. This scoping review aims to evaluate the evidence regarding the use of salivary glucose as a biomarker to track glycemic changes in diabetic populations. Methods: This study adhered to the Joanna Briggs Institute guidelines
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Bhawal, Ruchika, Ann L. Oberg, Sheng Zhang, and Manish Kohli. "Challenges and Opportunities in Clinical Applications of Blood-Based Proteomics in Cancer." Cancers 12, no. 9 (2020): 2428. http://dx.doi.org/10.3390/cancers12092428.

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Blood is a readily accessible biofluid containing a plethora of important proteins, nucleic acids, and metabolites that can be used as clinical diagnostic tools in diseases, including cancer. Like the on-going efforts for cancer biomarker discovery using the liquid biopsy detection of circulating cell-free and cell-based tumor nucleic acids, the circulatory proteome has been underexplored for clinical cancer biomarker applications. A comprehensive proteome analysis of human serum/plasma with high-quality data and compelling interpretation can potentially provide opportunities for understanding
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7

Mauriz, Elba. "Low-Fouling Substrates for Plasmonic Sensing of Circulating Biomarkers in Biological Fluids." Biosensors 10, no. 6 (2020): 63. http://dx.doi.org/10.3390/bios10060063.

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The monitoring of biomarkers in body fluids provides valuable prognostic information regarding disease onset and progression. Most biosensing approaches use noninvasive screening tools and are conducted in order to improve early clinical diagnosis. However, biofouling of the sensing surface may disturb the quantification of circulating biomarkers in complex biological fluids. Thus, there is a great need for antifouling interfaces to be designed in order to reduce nonspecific adsorption and prevent inactivation of biological receptors and loss of sensitivity. To address these limitations and en
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Li, Peiyao, Zihao Xu, Tao Liu, et al. "Circular RNA Sequencing Reveals Serum Exosome Circular RNA Panel for High-Grade Astrocytoma Diagnosis." Clinical Chemistry 68, no. 2 (2022): 332–43. http://dx.doi.org/10.1093/clinchem/hvab254.

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Abstract Background Although major advances have been made in the histopathological diagnosis of high-grade astrocytoma (HGA), methods for effective and noninvasive diagnosis remain largely unknown. Exosomes can cross the blood–brain barrier and are readily accessible in human biofluids, making them promising biomarkers for HGA. Circular RNAs (circRNAs) have potential as tumor biomarkers owing to their stability, conservation, and tissue specificity. However, the landscape and characteristics of exosome circRNAs in HGA remain to be studied. Methods CircRNA deep sequencing and bioinformatics ap
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Wong, DTW. "Salivary Diagnostics." Operative Dentistry 37, no. 6 (2012): 562–70. http://dx.doi.org/10.2341/12-143-bl.

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SUMMARY Saliva is a noninvasive and accessible biofluid that permits early detection of oral and systemic diseases. Recent scientific and technologic advances have uncovered specific salivary biomarkers for a number of clinical conditions, including cancers, autoimmune diseases, and cardiovascular disorders. The availability of highly sensitive and high-throughput assays such as microarray, mass spectrometry, reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) and nano-scale sensors that can measure proteins and nucleic acids are poising saliva as an emerging biofluid for tr
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10

Harvey, Peter, and Graham Farebrother. "Making data readily accessible." Leading Edge 15, no. 12 (1996): 1357–58. http://dx.doi.org/10.1190/1.1437261.

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11

Dearden, Michael J., Catherine R. Firkin, Jean-Paul R. Hermet, and Peter O'Brien. "A Readily-Accessible (+)-Sparteine Surrogate." Journal of the American Chemical Society 124, no. 40 (2002): 11870–71. http://dx.doi.org/10.1021/ja027774v.

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12

Sletten, Ellen M., and Timothy M. Swager. "Readily accessible multifunctional fluorous emulsions." Chemical Science 7, no. 8 (2016): 5091–97. http://dx.doi.org/10.1039/c6sc00341a.

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Mixtures of perfluorocarbon and water containing functionalized polymer surfactants and fluorous-tagged small molecules yield multifunctional emulsions with defined functionality on the inside and outside of the droplets.
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13

Kendarini, Ni Putu Yenny, Tjokorda Gde Bagus Mahadewa, and Ni Putu Tesi Maratni. "Role of Circulating microRNA as a Potential Biomarker in Metastatic Breast Cancer." International Journal of Health Sciences and Research 13, no. 7 (2023): 122–35. http://dx.doi.org/10.52403/ijhsr.20230719.

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Background: Breast cancer is the highest incidence among cancers in women, which diagnosed by tissue biopsy. These disadvantages, such as the invasive technique itself and the suffer from surgical procedure, make liquid or biofluid biopsies are further studied. The extracellualar or circulating microRNAs (miRNAs), has opened up new opportunities for early cancer diagnosis, because the method is non-invasive and simpler than tissue biopsies. Their presence in the circulation can be either cell-free or wrapped in vesicle membranes such as exosomes, microparticles, and apoptotic bodies, making mi
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14

Benni, Deepa, KM Pallavi, Tejaswi Maddukuri, et al. "Salivary diagnostics: Bridging dentistry and medicine: A systematic review." Bioinformation 20, no. 12 (2024): 1754–59. https://doi.org/10.6026/9732063002001754.

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Saliva has emerged as a non-invasive, easily accessible biofluid for diagnostic purposes in dentistry and medicine. Biomarkers in saliva, such as proteins, enzymes, nucleic acids, and metabolites, reflect both systemic and oral health. Advances in molecular science, nanotechnology, and bioinformatics have enabled highly accurate assays for early disease detection, monitoring, and treatment guidance. Salivary diagnostics are promising for identifying conditions like diabetes, HIV, COVID-19, autoimmune disorders, cardiovascular diseases, and oral diseases such as periodontal disease and oral can
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15

Levandowski, Brian J., Raymond F. Gamache, Jennifer M. Murphy, and K. N. Houk. "Readily Accessible Ambiphilic Cyclopentadienes for Bioorthogonal Labeling." Journal of the American Chemical Society 140, no. 20 (2018): 6426–31. http://dx.doi.org/10.1021/jacs.8b02978.

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16

Godfrey, K. R., A. H. Tan, and H. A. Barker. "A Survey of Readily Accessible Perturbation Signals." IFAC Proceedings Volumes 36, no. 16 (2003): 633–38. http://dx.doi.org/10.1016/s1474-6670(17)34832-2.

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17

Rowley, Julian H., Sze Chak Yau, Benson M. Kariuki, Alan R. Kennedy, and Nicholas C. O. Tomkinson. "Readily accessible chiral at nitrogen cage structures." Organic & Biomolecular Chemistry 11, no. 13 (2013): 2198. http://dx.doi.org/10.1039/c3ob27458f.

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18

Li, Kai, Yu Xiang, AiJun Tong, and Ben Zhong Tang. "Readily accessible rhodamine B-based photoresponsive material." Science China Chemistry 57, no. 2 (2013): 248–51. http://dx.doi.org/10.1007/s11426-013-5033-3.

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19

Long, Jintao, Genhua Pan, Emmanuel Ifeachor, Robert Belshaw, and Xinzhong Li. "Discovery of Novel Biomarkers for Alzheimer’s Disease from Blood." Disease Markers 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/4250480.

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Blood-based biomarkers for Alzheimer’s disease would be very valuable because blood is a more accessible biofluid and is suitable for repeated sampling. However, currently there are no robust and reliable blood-based biomarkers for practical diagnosis. In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection methods to find panels consisting of two and three biomarkers. We validated these biomarker sets using another serum cohort and an RNA profile cohort from the brain. Our panels included the proteins ECH1, NHLRC2, HOXB7, FN
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20

Habli, Zeina, Firas Kobeissy, and Massoud L. Khraiche. "Advances in point-of-care platforms for traumatic brain injury: recent developments in diagnostics." Reviews in the Neurosciences 33, no. 3 (2022): 327–45. http://dx.doi.org/10.1515/revneuro-2021-0103.

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Abstract Traumatic brain injury (TBI) is a major cause of mortality and morbidity, affecting 2 million people annually in the US alone, with direct and indirect costs of $76.3 billion per year. TBI is a progressive disease with no FDA-approved drug for treating patients. Early, accurate and rapid diagnosis can have significant implications for successful triaging and intervention. Unfortunately, current clinical tests for TBI rely on CT scans and MRIs, both of which are expensive, time-consuming, and not accessible to everyone. Recent evidence of biofluid-based biomarkers being released right
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21

Loi, Samantha M., Dhamidhu Eratne, Alexander F. Santillo, and Dennis Velakoulis. "Biofluid biomarkers in distinguishing young-onset dementia from primary psychiatric disorders." Current Opinion in Psychiatry 38, no. 2 (2025): 134–43. https://doi.org/10.1097/yco.0000000000000979.

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Purpose of review There has been growing interest in the role of biofluid biomarkers to aid the diagnosis of dementia in older people. However, less attention has been given to younger people who have dementia (young-onset dementia), who frequently experience misdiagnoses of primary psychiatric disorders diagnostic delay and challenges accessing appropriate care. Recent findings We describe 12 studies from the previous 2 years of which the majority have investigated the role of neurofilament light chain protein (NfL) in blood and cerebrospinal fluid in distinguishing young-onset dementia from
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22

Gutierrez, Danielle B., Jessica L. Moore, Jaison Arivalagan, Tiffany Louie, Leslie Wilkinson, and Ray Clemens. "Abstract 7092: Cancer biomarker discovery with scalable biofluid proteomics." Cancer Research 84, no. 6_Supplement (2024): 7092. http://dx.doi.org/10.1158/1538-7445.am2024-7092.

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Abstract Biofluid proteomics opens opportunities for the discovery of early detection, diagnostic, and prognostic cancer biomarkers through non-invasive or minimally invasive screening. Plasma and serum are accessible sample types, however, the high dynamic range of proteins creates analytical challenges for the sensitive detection of potential biomarkers. In this work, we compare two proteomic approaches for large-scale cancer biomarker discovery: the Olink Proximity Extension Assay and the Seer Proteograph Product Suite. Olink Explore 3072 is an immunoassay that gains specificity by using du
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23

Scheller, Judith S., Gordon W. Irvine, and Martin J. Stillman. "Unravelling the mechanistic details of metal binding to mammalian metallothioneins from stoichiometric, kinetic, and binding affinity data." Dalton Transactions 47, no. 11 (2018): 3613–37. http://dx.doi.org/10.1039/c7dt03319b.

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24

Pannkuk, Evan L., Igor Shuryak, Anika Kot, Lorreta Yun-Tien Lin, Heng-Hong Li, and Albert J. Fornace. "Host microbiome depletion attenuates biofluid metabolite responses following radiation exposure." PLOS ONE 19, no. 5 (2024): e0300883. http://dx.doi.org/10.1371/journal.pone.0300883.

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Development of novel biodosimetry assays and medical countermeasures is needed to obtain a level of radiation preparedness in the event of malicious or accidental mass exposures to ionizing radiation (IR). For biodosimetry, metabolic profiling with mass spectrometry (MS) platforms has identified several small molecules in easily accessible biofluids that are promising for dose reconstruction. As our microbiome has profound effects on biofluid metabolite composition, it is of interest how variation in the host microbiome may affect metabolomics based biodosimetry. Here, we ‘knocked out’ the mic
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Ilin, Egor A., Vladimir O. Smirnov, Alexander D. Volodin, Alexander A. Korlyukov, and Alexander D. Dilman. "ortho-Dialkylamino arylboranes as efficient reagents for difluorocarbene trapping." Chemical Communications 56, no. 52 (2020): 7140–42. http://dx.doi.org/10.1039/d0cc02567d.

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Pascal, Simon, Céline Besnard, Francesco Zinna, et al. "Zwitterionic [4]helicene: a water-soluble and reversible pH-triggered ECD/CPL chiroptical switch in the UV and red spectral regions." Organic & Biomolecular Chemistry 14, no. 20 (2016): 4590–94. http://dx.doi.org/10.1039/c6ob00752j.

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Shamsabadi, André, Jack Ren, and Vijay Chudasama. "Enabling the facile conversion of acyl hydrazides into N-acyl carbamates via metal-free ionic-based rupture of the N–N linkage." RSC Advances 7, no. 44 (2017): 27608–11. http://dx.doi.org/10.1039/c7ra04178k.

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Yadagiri, Dongari, та Pazhamalai Anbarasan. "Tandem 1,2-sulfur migration and (aza)-Diels–Alder reaction of β-thio-α-diazoimines: rhodium catalyzed synthesis of (fused)-polyhydropyridines, and cyclohexenes". Chemical Science 6, № 10 (2015): 5847–52. http://dx.doi.org/10.1039/c5sc02379c.

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Syed, Mohammed S., Janardhana R. Punuru, Kerry M. Dooley, and F. Carl Knopf. "A Readily Accessible Platform for Detailed Combustion Emissions Calculations." International Journal of Mechanical Engineering Education 40, no. 4 (2012): 289–304. http://dx.doi.org/10.7227/ijmee.40.4.3.

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Zhang, Xuehai, Meenakshi N. Rao, Stephen R. Jones, et al. "Synthesis of Squalamine Utilizing a Readily Accessible Spermidine Equivalent." Journal of Organic Chemistry 63, no. 23 (1998): 8599–603. http://dx.doi.org/10.1021/jo981344z.

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31

Murakami, Nobutoshi, Motoyuki Kawanishi, Sawako Itagaki, Toshihiro Horii, and Motomasa Kobayashi. "New readily accessible peroxides with High Anti-malarial Potency." Bioorganic & Medicinal Chemistry Letters 12, no. 1 (2002): 69–72. http://dx.doi.org/10.1016/s0960-894x(01)00673-4.

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32

Grygorenko, Oleksandr O., Dmytro S. Radchenko, Igor Dziuba, Alexander Chuprina, Kateryna E. Gubina, and Yurii S. Moroz. "Generating Multibillion Chemical Space of Readily Accessible Screening Compounds." iScience 23, no. 11 (2020): 101681. http://dx.doi.org/10.1016/j.isci.2020.101681.

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Grygorenko, Oleksandr O., Dmytro S. Radchenko, Igor Dziuba, Alexander Chuprina, Kateryna E. Gubina, and Yurii S. Moroz. "Generating Multibillion Chemical Space of Readily Accessible Screening Compounds." iScience 23, no. 12 (2020): 101873. http://dx.doi.org/10.1016/j.isci.2020.101873.

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34

Despax, Laurie, Juliette Fitremann, Mathias Destarac, and Simon Harrisson. "Low concentration thermoresponsive hydrogels from readily accessible triblock copolymers." Polymer Chemistry 7, no. 20 (2016): 3375–77. http://dx.doi.org/10.1039/c6py00499g.

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Dilute (&lt;1 wt%) aqueous solutions of ultrahigh molecular weight triblock copolymers (with M<sub>n</sub> up to 500 000 g mol<sup>−1</sup>) comprising a long central hydrophilic block of polydimethylacrylamide and shorter terminal blocks of poly(N-isopropylacrylamide) form gels on heating.
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Schwesinger, Reinhard. "Tricyclic 2,4-Diaminovinamidines– Readily Accessible, Very Strong CHN Bases." Angewandte Chemie International Edition in English 26, no. 11 (1987): 1164–65. http://dx.doi.org/10.1002/anie.198711641.

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36

Malpani, Anand, Colin Lea, Chi Chiung Grace Chen, and Gregory D. Hager. "System events: readily accessible features for surgical phase detection." International Journal of Computer Assisted Radiology and Surgery 11, no. 6 (2016): 1201–9. http://dx.doi.org/10.1007/s11548-016-1409-0.

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37

Guthrie, Quibria A. E., Hailey A. Young, and Caroline Proulx. "Ketoxime peptide ligations: oxidative couplings of alkoxyamines to N-aryl peptides." Chemical Science 10, no. 41 (2019): 9506–12. http://dx.doi.org/10.1039/c9sc04028e.

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Chaitanya, Manthena, and Pazhamalai Anbarasan. "Recent developments and applications of cyanamides in electrophilic cyanation." Organic & Biomolecular Chemistry 16, no. 39 (2018): 7084–103. http://dx.doi.org/10.1039/c8ob01770k.

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Martínez-Ferraté, Oriol, Basujit Chatterjee, Christophe Werlé, and Walter Leitner. "Hydrosilylation of carbonyl and carboxyl groups catalysed by Mn(i) complexes bearing triazole ligands." Catalysis Science & Technology 9, no. 22 (2019): 6370–78. http://dx.doi.org/10.1039/c9cy01738k.

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40

Do, Jean-Louis, Hatem M. Titi, Louis A. Cuccia, and Tomislav Friščić. "A new class of anionic metallohelicates based on salicylic and terephthalic acid units, accessible in solution and by mechanochemistry." Chemical Communications 57, no. 42 (2021): 5143–46. http://dx.doi.org/10.1039/d0cc08180a.

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41

Tran, F., C. S. Lancefield, P. C. J. Kamer, T. Lebl та N. J. Westwood. "Selective modification of the β–β linkage in DDQ-treated Kraft lignin analysed by 2D NMR spectroscopy". Green Chemistry 17, № 1 (2015): 244–49. http://dx.doi.org/10.1039/c4gc01012d.

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Zahorska, Eva, Sakonwan Kuhaudomlarp, Saverio Minervini, et al. "A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate." Chemical Communications 56, no. 62 (2020): 8822–25. http://dx.doi.org/10.1039/d0cc03490h.

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Fuse, Shinichiro, Tsukasa Oishi, Keisuke Matsumura, Yoshihiro Hayashi, Susumu Kawauchi та Hiroyuki Nakamura. "Design, synthesis, and evaluation of azo D–π-A dyes as photothermal agents". Organic & Biomolecular Chemistry 18, № 1 (2020): 93–101. http://dx.doi.org/10.1039/c9ob02066g.

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Karnakanti, Shuklachary, Zhong-Lin Zang, Sheng Zhao, Pan-Lin Shao, Ping Hu, and Yun He. "Palladium-catalyzed oxidative arylacetoxylation of alkenes: synthesis of indole and indoline derivatives." Chem. Commun. 53, no. 81 (2017): 11205–8. http://dx.doi.org/10.1039/c7cc06448a.

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Wang, Jinjin, Ping Lu, and Yanguang Wang. "Copper-catalyzed multi-component synthesis of acrylamidines and benzoimidazoles." Organic Chemistry Frontiers 2, no. 10 (2015): 1346–51. http://dx.doi.org/10.1039/c5qo00196j.

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Borisov, Sergey M., Abraham Alemayehu, and Abhik Ghosh. "Osmium-nitrido corroles as NIR indicators for oxygen sensors and triplet sensitizers for organic upconversion and singlet oxygen generation." Journal of Materials Chemistry C 4, no. 24 (2016): 5822–28. http://dx.doi.org/10.1039/c6tc01126h.

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Dong, Xu, Li Chen, Zhitong Zheng, Xu Ma, Zaigang Luo, and Liming Zhang. "Silver-catalyzed stereoselective formation of glycosides using glycosyl ynenoates as donors." Chemical Communications 54, no. 62 (2018): 8626–29. http://dx.doi.org/10.1039/c8cc02494d.

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48

Ivanoff, Thomas A., and Jonathan D. Madison. "Using 3D Characterization and Serial Sectioning to Improve Materials Analysis." AM&P Technical Articles 178, no. 1 (2020): 16–21. http://dx.doi.org/10.31399/asm.amp.2020-01.p016.

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Vodak, M. "Hot Tips: Fire Information at Your Fingertips." Journal of Forestry 99, no. 11 (2001): 48. http://dx.doi.org/10.1093/jof/99.11.48.

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Ivanchenko, Oleksandr, Ugo Authesserre, Guilhem Coste, Stéphane Mazières, Mathias Destarac та Simon Harrisson. "ε-Thionocaprolactone: an accessible monomer for preparation of degradable poly(vinyl esters) by radical ring-opening polymerization". Polymer Chemistry 12, № 13 (2021): 1931–38. http://dx.doi.org/10.1039/d1py00080b.

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