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Relevant bibliographies by topics / A-site finger

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Academic literature on the topic 'A-site finger'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "A-site finger"

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Du, Jian, Dharmesh Vyas, Qing Xi, and Steven J. Ackerman. "Functional Differences in GATA-1 Affinity for Double Versus Single GATA-1 Binding Sites Dictate Synergistic Versus Antagonistic Interactions of PU.1 and GATA-1 in Myeloid Gene Transcription." Blood 104, no. 11 (2004): 1608. http://dx.doi.org/10.1182/blood.v104.11.1608.1608.

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Abstract Instructive roles for both GATA-1 and PU.1 have been demonstrated in hematopoiesis, and recent studies have identified both antagonistic and synergistic interactions between them in myeloid gene transcription and lineage development. In prior studies, we reported that PU.1 synergizes with rather than antagonizes GATA-1 for transactivation of a hallmark eosinophil gene, the major basic protein P2 promoter (MBP-P2), which possesses a novel dual (double) GATA-binding site, similar to the palindromic double site in the murine GATA-1 control locus that may specify eosinophil lineage-specif

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Thukral, S. K., M. L. Morrison, and E. T. Young. "Mutations in the zinc fingers of ADR1 that change the specificity of DNA binding and transactivation." Molecular and Cellular Biology 12, no. 6 (1992): 2784–92. http://dx.doi.org/10.1128/mcb.12.6.2784.

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ADR1 is a yeast transcription factor that contains two zinc fingers of the Cys-2-His-2 (C2H2) class. Mutations that change the specificity of DNA binding of ADR1 to its target site, upstream activation sequence 1 (UAS1), have been identified at three positions in the first zinc finger. Mutations Arg-115 to Gln, His-118 to Thr, and Arg-121 to Asn led to new specificities of DNA binding at adjacent positions 10, 9, and 8 (3'-GAG-5') in UAS1. Arg-115 is at the finger tip, and His-118 and Arg-121 are at positions 3 and 6, respectively, in the alpha helix of finger 1. One double mutant displayed th

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Thukral, S. K., M. L. Morrison, and E. T. Young. "Mutations in the zinc fingers of ADR1 that change the specificity of DNA binding and transactivation." Molecular and Cellular Biology 12, no. 6 (1992): 2784–92. http://dx.doi.org/10.1128/mcb.12.6.2784-2792.1992.

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ADR1 is a yeast transcription factor that contains two zinc fingers of the Cys-2-His-2 (C2H2) class. Mutations that change the specificity of DNA binding of ADR1 to its target site, upstream activation sequence 1 (UAS1), have been identified at three positions in the first zinc finger. Mutations Arg-115 to Gln, His-118 to Thr, and Arg-121 to Asn led to new specificities of DNA binding at adjacent positions 10, 9, and 8 (3'-GAG-5') in UAS1. Arg-115 is at the finger tip, and His-118 and Arg-121 are at positions 3 and 6, respectively, in the alpha helix of finger 1. One double mutant displayed th

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Hasegawa, Atsushi, Hiroshi Kaneko, Daishi Ishihara, et al. "GATA1 Changes DNA-Binding Fashion in a Binding-Site-Specific Manner and Alters Transcriptional Activity during Erythropoiesis." Blood 126, no. 23 (2015): 3584. http://dx.doi.org/10.1182/blood.v126.23.3584.3584.

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Abstract GATA1 is a transcription factor that coordinately regulates multiple target genes during the development and differentiation of erythroid and megakaryocytic lineages through binding to GATA motif (A/T)GATA(A/G). GATA1 has four functional domains, i.e., two transactivation domains reside in amino- and carboxyl- terminus, which transactivate GATA1 target genes redundantly and/or cooperatively, and two zinc-finger domains in the middle of the protein. The two zinc finger domains of GATA1 have been characterized extensively and their links to human diseases have also been identified. Carb

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Morris, J. F., R. Hromas, and F. J. Rauscher. "Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core." Molecular and Cellular Biology 14, no. 3 (1994): 1786–95. http://dx.doi.org/10.1128/mcb.14.3.1786.

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The myeloid zinc finger gene 1, MZF1, encodes a transcription factor which is expressed in hematopoietic progenitor cells that are committed to myeloid lineage differentiation. MZF1 contains 13 C2H2 zinc fingers arranged in two domains which are separated by a short glycine- and proline-rich sequence. The first domain consists of zinc fingers 1 to 4, and the second domain is formed by zinc fingers 5 to 13. We have determined that both sets of zinc finger domains bind DNA. Purified, recombinant MZF1 proteins containing either the first set of zinc fingers or the second set were prepared and use

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Morris, J. F., R. Hromas, and F. J. Rauscher. "Characterization of the DNA-binding properties of the myeloid zinc finger protein MZF1: two independent DNA-binding domains recognize two DNA consensus sequences with a common G-rich core." Molecular and Cellular Biology 14, no. 3 (1994): 1786–95. http://dx.doi.org/10.1128/mcb.14.3.1786-1795.1994.

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The myeloid zinc finger gene 1, MZF1, encodes a transcription factor which is expressed in hematopoietic progenitor cells that are committed to myeloid lineage differentiation. MZF1 contains 13 C2H2 zinc fingers arranged in two domains which are separated by a short glycine- and proline-rich sequence. The first domain consists of zinc fingers 1 to 4, and the second domain is formed by zinc fingers 5 to 13. We have determined that both sets of zinc finger domains bind DNA. Purified, recombinant MZF1 proteins containing either the first set of zinc fingers or the second set were prepared and use

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Drummond, I. A., H. D. Rupprecht, P. Rohwer-Nutter, et al. "DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1." Molecular and Cellular Biology 14, no. 6 (1994): 3800–3809. http://dx.doi.org/10.1128/mcb.14.6.3800.

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The Wilms' tumor suppressor, WT1, is a zinc finger transcriptional regulator which exists as multiple forms owing to alternative mRNA splicing. The most abundant splicing variants contain a nine-nucleotide insertion encoding lysine, threonine, and serine (KTS) in the H-C link region between the third and fourth WT1 zinc fingers which disrupts binding to a previously defined WT1-EGR1 binding site. We have identified WT1[+KTS] binding sites in the insulin-like growth factor II gene and show that WT1[+KTS] represses transcription from the insulin-like growth factor II P3 promoter. The highest aff

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Drummond, I. A., H. D. Rupprecht, P. Rohwer-Nutter, et al. "DNA recognition by splicing variants of the Wilms' tumor suppressor, WT1." Molecular and Cellular Biology 14, no. 6 (1994): 3800–3809. http://dx.doi.org/10.1128/mcb.14.6.3800-3809.1994.

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The Wilms' tumor suppressor, WT1, is a zinc finger transcriptional regulator which exists as multiple forms owing to alternative mRNA splicing. The most abundant splicing variants contain a nine-nucleotide insertion encoding lysine, threonine, and serine (KTS) in the H-C link region between the third and fourth WT1 zinc fingers which disrupts binding to a previously defined WT1-EGR1 binding site. We have identified WT1[+KTS] binding sites in the insulin-like growth factor II gene and show that WT1[+KTS] represses transcription from the insulin-like growth factor II P3 promoter. The highest aff

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Gebelein, Brian, and Raul Urrutia. "Sequence-Specific Transcriptional Repression by KS1, a Multiple-Zinc-Finger–Krüppel-Associated Box Protein." Molecular and Cellular Biology 21, no. 3 (2001): 928–39. http://dx.doi.org/10.1128/mcb.21.3.928-939.2001.

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ABSTRACT The vertebrate genome contains a large number of Krüppel-associated box–zinc finger genes that encode 10 or more C2-H2 zinc finger motifs. Members of this gene family have been proposed to function as transcription factors by binding DNA through their zinc finger region and repressing gene expression via the KRAB domain. To date, however, no Krüppel-associated box–zinc finger protein (KRAB-ZFP) and few proteins with 10 or more zinc finger motifs have been shown to bind DNA in a sequence-specific manner. Our laboratory has recently identified KS1, a member of the KRAB-ZFP family that

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Tsai, Robert Y. L., and Randall R. Reed. "Identification of DNA Recognition Sequences and Protein Interaction Domains of the Multiple-Zn-Finger Protein Roaz." Molecular and Cellular Biology 18, no. 11 (1998): 6447–56. http://dx.doi.org/10.1128/mcb.18.11.6447.

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ABSTRACT Roaz, a rat C2H2 zinc finger protein, plays a role in the regulation of olfactory neuronal differentiation through its interaction with the Olf-1/EBF transcription factor family. An additional role for the Roaz/Olf-1/EBF heterodimeric protein is suggested by its ability to regulate gene activation at a distinct promoter lacking Olf-1/EBF-binding sites. Using an in vitro binding-site selection assay (Selex), we demonstrate that Roaz protein binds to novel inverted perfect or imperfect repeats of GCACCC separated by 2 bp. We show that Roaz is capable of binding to a canonical consensus

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Dissertations / Theses on the topic "A-site finger"

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Crandall, Jacob N. "Ribosomal RNA Mutations that Inhibit the Activity of Transfer-Messenger RNA of Stalled Ribosomes." Diss., CLICK HERE for online access, 2010. http://contentdm.lib.byu.edu/ETD/image/etd3535.pdf.

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Abdelrahman, Akmal H. H. "Compositional structures in mural design : towards a site-specific deconstructive mural methodology." Thesis, University of Bedfordshire, 2009. http://hdl.handle.net/10547/133549.

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Murals have been the formal visual interpretation of the cultural, social and political life of all ages. Throughout they have been consistently combined with their architectural setting, for example, in ancient Egyptian tombs, in Renaissance churches and on the external walls of buildings in Mexico in the twentieth century. This is a central feature of mural painting. However many contemporary murals do not integrate with their architectural settings, in other words, do not fulfil the site-specificity of the architectural spaces for which they were made. This means that the most important asp

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Dillenschneider, Raoul. "Effects of a strict site-occupation constraint in the description of quantum spin systems at finite temperature." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. https://publication-theses.unistra.fr/public/theses_doctorat/2006/DILLENSCHNEIDER_Raoul_2006.pdf.

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Roig, Rodelas Roger. "Chemical characterization, sources and origins of secondary inorganic aerosols measured at a suburban site in Northern France." Thesis, Lille 1, 2018. http://www.theses.fr/2018LIL1R017/document.

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Les particules fines troposphériques de diamètre aérodynamique inférieur à 2,5 µm (PM2.5) peuvent impacter la santé et les écosystèmes. Les aérosols inorganiques secondaires (AIS) et organiques (AO) contribuent fortement aux PM2.5. Pour comprendre leur formation et leur origine, une campagne d’1 an (août 2015 - juillet 2016) de mesures horaires de gaz précurseurs inorganiques et d’ions hydrosolubles particulaires a été menée sur un site urbain du nord de la France avec un MARGA 1S, complétées par les concentrations massiques en PM2.5, carbone suie, oxydes d’azote et éléments traces. Des niveau

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Alexander, Amanda S. "Collaboratively Developing a Web site with Artists in Cajamarca, Peru: A Participatory Action Research Study." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1276529007.

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Cohen, Annette. "In Situ Vision: The Student Experience of Collaborative Learning in a Virtual Drawing Class." Antioch University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1363112768.

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Williams, Cornelia C. "Satyrica signa: A Campana relief from the Via Gabina Villa at Site 10 (Italy)." Thesis, 1989. http://hdl.handle.net/1911/13410.

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This thesis considers one Campana relief fragment, depicting two satyrs looking into a basin with a lion's head above and between them, found at the Site 10 Roman villa, and explores its form, meaning and context. Comparisons with other Campana reliefs depicting the same scene indicate that stylistic criteria are not always sufficient for dating the reliefs. Archaeological evidence (brickstamps and wine-making press) from Phase IIa of the villa would indicate a structural and functional expansion of the villa c.40 A.D. On the basis of this archaeological evidence and comparison of the fragment

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Tsai, Yi Pei, and 蔡宜霈. "A Study of On-chip In-Situ Chamber Recorders for Plasma Induced Damage Effect in Advanced FinFET Technologies." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/n39e43.

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Růžičková, Anna. "Studium druhové bohatosti a složení společenstev mechorostů na velmi malé prostorové škále v souvislosti s in situ měřeným mikroklimatem." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-445969.

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The life of bryophytes is closely connected with their surrounding environment. Changes in atmospheric conditions on the microscale directly affect the physiological functions of bryophytes, which in turn determine their distribution. The current development of technologies allows us to measure the microclimate affecting bryophytes directly in the field. Nevertheless, there have not been many studies published examining the response of bryophytes to in situ measured microclimate. This diploma thesis is one of the first in Europe to provide data from continuous field microclimatic measurement p

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Books on the topic "A-site finger"

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Thomas, Richard, Sarah Thomas, David Andrew, and Alan McBride. Complete Guide to Finding the Birds of Australia. CSIRO Publishing, 2011. http://dx.doi.org/10.1071/9780643097865.

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First published in 1994, The Complete Guide to Finding the Birds of Australia was the first ever book of its type in Australia – a complete guide to locating every resident bird species in Australia, plus supplementary information on where to find rarities, migratory species and logistical information. This fully revised second edition expands on the best-selling appeal of the first, describing the best-known sites for all of Australia’s endemic birds, plus vagrants and regular migrants such as seabirds and shorebirds. It covers all states and territories, and is the first guide to inclu

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Pluckhahn, Thomas J., and Victor D. Thompson. New Histories of Village Life at Crystal River. University Press of Florida, 2018. http://dx.doi.org/10.5744/florida/9781683400356.001.0001.

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The tension between competition and cooperation has emerged as a major topic of concern in the understanding of human societies. The dynamic is epitomized by societies undergoing the transition to larger and more permanent villages, referred to as “early village” societies. This study describes archaeological research directed toward the understanding of early village formation at the Crystal River and Roberts Island sites in west-central Florida. Crystal River has long recognized as one of the preeminent sites of the Woodland period (ca. 1000 B.C. to A.D. 1000) in the American Southeast; Robe

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Salillas, Elena, and Carlo Semenza. Mapping the Brain for Math. Edited by Roi Cohen Kadosh and Ann Dowker. Oxford University Press, 2014. http://dx.doi.org/10.1093/oxfordhb/9780199642342.013.046.

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Brain stimulation techniques allow for the search of crucial areas for a given function. Not always convergent with neuroimaging, TMS studies have targeted parietal areas critical for quantity representation, spatio-numerical links, numerical and non-numerical quantity, finger gnosis and calculation. TMS data indicate the intraparietal sulcus and surrounding areas in the left and right hemisphere as crucial for quantity processing, although left hemisphere might be dominant. Bilateral parietal loci are essential for calculation and bilateral parietal areas are behind the spatio-numerical link,

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Doepke, Laura. Fine, Linear/Branching Calcifications. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0041.

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Of all of the calcifications identified on mammography, fine, linear/branching calcifications are the most suspicious for malignancy, most commonly ductal carcinoma in situ (DCIS). The risk of malignancy associated with fine, linear/branching calcifications is approximately 70%. A recent study evaluating the positive predictive value of suspicious calcifications based on the fifth edition of BI-RADS found the positive predictive value of fine pleomorphic/linear or segmental calcifications was 93.8%. This chapter, which appears in the section on calcifications, reviews the key imaging features,

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Poplack, Shana. Confirmation through replication. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190256388.003.0007.

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This chapter reviews a series of replications of the studies reported in previous chapters on eight typologically distinct language pairs, making use of a wide array of phonological, morphological, and syntactic diagnostics (e.g., vowel harmony, word order, case-marking, adjectival expression, nominal determination patterns, verb incorporation strategies). Wherever a conflict site between donor and recipient languages could be determined, lone items were systematically shown to behave like the latter, often to the point of assuming the fine details of its variable quantitative conditioning. Re

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Lee-Felker, Stephanie A., and Colin J. Wells. Pleomorphic Calcifications. Edited by Christoph I. Lee, Constance D. Lehman, and Lawrence W. Bassett. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190270261.003.0042.

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Pleomorphic calcifications are categorized among calcifications with suspicious morphology: amorphous, coarse heterogeneous, fine linear or fine-linear branching, and fine pleomorphic calcifications. Unlike amorphous calcifications, pleomorphic calcifications are more conspicuous, with discernible shapes that appear predominantly irregular, and are variable in size and configuration. A segmental distribution, seen as a triangular shape with its apex centered at the nipple, is especially suspicious for ductal carcinoma in situ (DCIS) or multifocal breast cancer, as its pattern of calcium deposi

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Wilson, Emily Herring. Val-Kill Industries. University of North Carolina Press, 2018. http://dx.doi.org/10.5149/northcarolina/9781469635835.003.0011.

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In 1927 with Nancy Cook at the helm, the three friends (plus Caroline O'Day as a partner) opened a small furniture factory on site, and hired several skilled wood workmen (NYC immigrants) to produce fine American reproduction furniture. Eleanor Roosevelt bought many pieces, encouraged purchases by her friends, and Val-Kill had sales exhibits in NYC. Although they never were able to employ a large number of local workers, as Nancy and Eleanor and FDR had hoped would be a precursor of later New Deal employment projects, for about a decade they kept the business going during the most difficult ye

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Baron, Alan, John Hassard, Fiona Cheetham, and Sudi Sharifi. Touring the Hospice. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780198813958.003.0007.

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This chapter continues the analysis of organizational culture at the host Hospice under ethnographic investigation. Having discussed the cultural make-up of the ‘old’ Hospice, and then glimpsed something of the ‘new’, the study now focuses on the latter to illuminate the nature of the organization as the authors interpreted it at the time the research was carried out. In so doing, the study once again returns to Schein’s three-level culture model and primarily his analytical level of organizational ‘artefacts’, as the focus for a ‘tour’ of the case study site. This sees staff and volunteers de

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Ledger-Lomas, Michael. Ministers and Ministerial Training. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780199683710.003.0021.

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Protestant Dissent was assailed by Anglo-Catholics in England and by the Mercersburg Theologians in the United States for its fissiparous tendencies, sectarian nature, and privileging of emotional conversionism over apostolic order and objective, sacramental religion. Yet this chapter argues that personal conversion was essential to the faith of Dissent and the key to its spirituality, worship, and congregational life. Whether conversion was gradual or instantaneous, it remained the point of entry into the Christian life and the full privileges of church membership. Spurred by the preaching of

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Book chapters on the topic "A-site finger"

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Boye, S., A. Opp, and H. Gehring. "Standardization of Controlled Vasoconstriction at the Finger Site for Pulse Oximeter Performance Assessment with Respect to a Perfusion Index." In IFMBE Proceedings. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-03885-3_183.

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Sadun, Amirul Syafiq, and Jamaludin Jalani. "Model Identification of a 3 Finger Adaptive Robot Gripper by Using MATLAB SIT." In Towards Autonomous Robotic Systems. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64107-2_30.

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Greenbaum, Nancy L. "Role of a conserved pseudouridine in U2 snRNA on the structural and electrostatic features of the spliceosomal pre-mRNA branch site." In Fine-Tuning of RNA Functions by Modification and Editing. Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/b106846.

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Frers, Lars. "Conclusions: Touching and Being Touched – Experience and Ethical Relations." In IMISCOE Research Series. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67608-7_5.

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AbstractSometimes, research can hit you in the stomach, making you angry and upset, possibly sick. With a bit of luck, this can be fine, as discontentment can be a force that propels you to become active and engage yourself. Sometimes, research can resonate in your heart, making you aware and empathetic. Not much luck is needed in these cases, as this will hopefully also stimulate you to get new ideas, a better understanding or hopefully even give you a better foothold for whatever you do in practice. Most of the time, research just passes you by, not leaving much of an impression. We do know that words can make a difference, that words can touch you. They evoke many different thoughts and emotions. It is not a single word alone that does this, it is the flow and rhythm of a text, how it takes the reader along, cognitively but also in space and time and in an embodied manner. To achieve different effects, we place words differently, we craft sentences that appeal to different senses and sensibilities, we use terms or jargon, we write complex sentences that juxtapose hosts of different qualities, as Michel Serres does in in The Five Senses (2008). We present a clear definition, we unfold arguments or put something to the point. Most of the word work we do, we do on our keyboards, sitting at a desk, in a train carriage or lying on a sofa. Thus, this word work happens remote from the site where our study took place, it is definitely not the same as the field work that we do, it is not the same as the numbers and algorithms that make up our data. But done well, it can still evoke the sense of what happens or happened “out there” in the field, the phenomena that the numbers point to, be they the numbers of people crossing a border or the feeling of someone who is lost or maybe even hunted (Guttorm, 2016).

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Sood, Rajiv, Joshua M. Adkinson, and Brett C. Hartman. "Trigger Finger." In Operative Plastic Surgery, edited by Gregory R. D. Evans. Oxford University Press, 2019. http://dx.doi.org/10.1093/med/9780190499075.003.0095.

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Stenosing flexor tenosynovitis of the digits, commonly known as trigger finger, is one of the most common conditions affecting the hand. It is characterized by a painful locking or clicking of the finger during flexion or extension. This can lead to significant pain or eventual flexion deformity. Treatment varies based on the duration, severity, and etiology and can be either conservative or operative. The complication rate of surgical intervention remains low, with the most common being pain at the operative site. Treatment of trigger finger in the patient with rheumatoid disease should be approached with caution. Overall management of trigger finger, whether conservative or operative, is routinely successful with the final result of a satisfied patient.

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Warrell, David A. "Orf." In Oxford Textbook of Medicine. Oxford University Press, 2010. http://dx.doi.org/10.1093/med/9780199204854.003.070527_update_001.

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Orf (‘ecthyma contagiosum’) is caused by an epitheliotropic parapox DNA virus of sheep and goats that is able to subdue the host’s immune response. It is an occupational zoonosis of people working with these animals. A painful papule/pustule develops, usually on a finger, the site of contact with lesions on the animal’s muzzle. Systemic effects are unusual, but include local lymphadenopathy, fever, erythema multiforme, and other generalized rashes. Spontaneous resolution within 6 weeks is usual. Multiple, giant lesions may develop in the immunosuppressed. Topical cidofovir is effective in severe cases....

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Gabelmann, Olga U., and Lawrence S. Owens. "Good, Bad, or Indifferent?" In The Odd, the Unusual, and the Strange. University Press of Florida, 2020. http://dx.doi.org/10.5744/florida/9781683401032.003.0007.

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Non-normative burials are comparatively understudied for the Andean area as a whole and are almost completely unknown for the Bolivian Formative period (1300 BC–AD 200). The current research discusses a unique case from the site of Aranjuez-Santa Lucía, where an adolescent was recovered with their finger inserted anally/vaginally, in a highly ambiguous archaeological context comprised of industrial waste, yet also containing other, conventional burials and pars pro toto offerings of considerable value. It is therefore impossible to assume the burial’s somewhat unorthodox position to be purely a sign of social censure for the deceased’s modus vivendi or moriendi. Various hypotheses and comparatives are offered, with particular emphasis on demographic factors. This case study complements others in the current volume in emphasizing the depth and complexity of lifeways and deathways, and further underscores the fact that a solely negative sense of “deviant” burial must necessarily be a simplistic one.

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Mastergeorge, Ann M., and Jacky Au. "Fragile X: A Family of Disorders." In Cognitive and Behavioral Abnormalities of Pediatric Diseases. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195342680.003.0024.

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Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability known, and it is the most common single gene disorder associated with autism (Belmonte and Bourgeron 2006; Reddy 2005). It is caused by the lack or deficiency of the FMR1 protein, FMRP (Loesch et al. 2004b). The typical physical features of FXS include prominent ears, hyperextensible finger joints, flat feet, soft skin, and in adolescence and adulthood large testicles (macroorchidism) and a long face (Hagerman 2002b). The behavioral features include poor eye contact, hyperarousal to stimuli, anxiety, hyperactivity, attention deficit, impulsivity, hand stereotypies (such as hand biting and hand flapping), and social deficits including autism and autism spectrum disorder (ASD) (Budimirovic et al. 2006; Clifford et al. 2007; Hall et al. 2008b; Hatton et al. 2006b; Sullivan et al. 2007b). Fragile-X syndrome was first reported by Lubs (1969) in two brothers who had intellectual disability and the appearance of a marker X chromosome, which is a fragile site on their X chromosome. It was later detected that this fragile site on the X chromosome only occurred when the chromosomes were studied in a folate-deficient tissue culture media (Sutherland 1977). Therefore cytogenetic studies were utilized to document cases of FXS throughout the 1980s until the Fragile X Mental Retardation 1 gene (FMR1) was discovered in 1991 (Verkerk et al. 1991). The FMR1 gene was found to have a trinucleotide (CGG) repeat sequence at the 5’ untranslated region, with the normal range later determined to be up to 44 repeats, a gray zone of 45–54 repeats, a premutation of 55–200 repeats, and a full mutation range of more than 200 repeats (Maddalena et al. 2001). Those individuals with the full mutation have a deficit or absence of the FMR1 protein (FMRP) that causes the physical, behavioral, and cognitive features of FXS (Loesch et al. 2004b). Females with the full mutation have another X chromosome that is producing FMRP, depending on the activation ratio (AR) or the percentage of cells that have the normal X chromosome as the active X chromosome.

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Jones, Richard J. "Washington as a Site of Muslim-Christian Encounter." In Fine Differences. International Institute of Islamic Thought, 2020. http://dx.doi.org/10.2307/j.ctv19prr4t.6.

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Magee, Patrick, and Mark Tooley. "Pulse Oximetry." In The Physics, Clinical Measurement and Equipment of Anaesthetic Practice for the FRCA. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199595150.003.0019.

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The pulse oximeter is a device for non-invasive, continuous measurement of oxygen saturation. As such it is arguably one of the most important intraoperative monitors at the disposal of anaesthetists, and efforts are being made to make pulse oximeters available at all operating locations throughout the world [Walker et al. 2009]. Although the device measures oxygen saturation of arterial blood, which is the physiological end point of interest, it is not a replacement for monitoring all the events which may lead to hypoxaemia; in other words it does not replace an oxygen analyser at the common gas outlet of the anaesthetic machine. Depending on the site of the probe, usually ear lobe or finger, there is a variable delay between the onset of a causative hypoxaemic event and detection of hypoxaemia by the pulse oximeter, the delay being longer the more peripherally placed is the probe. Appropriate size and design of the probe for accuracy and safety in children is important [Howell et al. 1993] and finger probes are more accurate but slower to respond than ear probes [Webb et al. 1991]. Forehead reflectance probes have been used with good results [Casati et al. 2007]. It is also true that the human eye is notoriously bad at detecting cyanosis in the range of saturations 81–85%. For additional information on Monitoring Principles see Chapter 11. It is clear, however, that in a hierarchy of monitors for anaesthesia, the pulse oximeter is indispensable. A pulse oximeter uses two separate technologies: one is plethysmography, where reproduction of the pulsatile waveform takes place; the other is spectroscopy, where absorption of light of specific wavelengths by body tissues occurs and is analysed. The spectroscopic aspects depend on the laws of Beer and Lambert, which can be combined to state that the amount of light absorbed by a substance is proportional to the thickness of the substance sample (the path length of the light) and the concentration of the substance.

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Conference papers on the topic "A-site finger"

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de la Torre, Roger A., and Jaya Ghosh. "Device for Safely Closing Trocar Sites in Minimally Invasive Abdominal Surgery." In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3399.

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Laparoscopic and robotic surgeries of the abdomen require a trocar to facilitate entry and removal of instrumentation. Some of these trocars are 5mm or less, but some trocars for these surgeries are larger, with 8mm to 15mm trocars commonly used. One of the well-known problems seen in minimally invasive surgery to the abdomen is the resulting defect left in the abdominal wall following removal of the trocars. Occasionally, especially after removal of larger trocars, a defect is left that is large enough to allow omentum or segments of small intestine to become entrapped within the resulting sp

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Higgins, Deborah L., and William E. Holmes. "CHARACTERIZATION OF RECOMBINANT HUMAN TISSUE-TYPE PLASMINOGEN ACTIVATOR MISSING THE FINGER DOMAIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643842.

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Site-specific mutagenesis was used to produce a mutant form of tissue-type plasminogen activator (t-PA) which was missing the first 44 amino acids. This domain has sequence homology with the type 1 regions in proteins such as fibronectin and is commonly called the finger domain. The mutant protein (des 1-44 t-PA) was expressed in Chinese Hampster Ovary cells, and was purified using chromatography on Zn-chelate sepharose and lysine-sepharose. Sequence analysis indicated that the resulting protein was homogeneous and started at amino acid 45 in the sequence of the normal protein. The two-chain f

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Larsen, Glenn R., Kim Henson, and Yitzak Blue. "BIOLOGICAL CHARACTERIZATION OF AMINO-TERMINAL EXON DELETIONS OF T-PA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643840.

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The secreted form of t-pa is proposed to be a mosaic protein which contains 4 different domain elements based on amino acid homologies with fibronectin finger elements, epidermal growth factor, kringle structures, and the active site of serine proteases. Of the 12 exons which encode these domains only the finger and epidermal growth factor are encoded separately by single exons. To investigate whether a single exon can encode a functional element or domain within a protein, the following precise exon alterations were made by loop-out mutagenesis techniques which deleted either the fibronectin

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Meusburger, S., R. Beckmann, J. Wojta, and B. R. Binder. "RELATION OP FIBRIN STIMULATION OF tPA MEDIATED PLASMINOGEN ACTIVATION AND FIBRIN BINDING TOWARDS FIBRONEKTIN AS REVEALED BY A MONOCLONAL ANTIBODY (MAB) AGAINST FCB-2 FIBRINOGEN FRAGMENTS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644403.

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Fibrin binds to the finger domain of fibronektin via the C-terminal end of the chain and it was reported previously by us that in a fluid phase assay fibronektin inhibits fibrin enhancement of plasminogen activation by tPA. However, other have shown that tPA binds to fibronectin thereby possibly mediating enhanced matrix bound plasmin formation. In the present study we tried to further characterize the interaction between fibronectin and fibrin in regard to fibrin dependent enhancement of plasminogen activation by tPA. For fibrin binding to fibronectin we have developed an ELISA system using f

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Verheijen, J. M., M. P. M. Caspers, G. A. W. de Munk, B. E. Enger-Valk, G. T. G. Chang, and P. H. Pouwels. "SITES IN TISSUE-TYPE PLASMINOGEN ACTIVATOR INVOLVED IN THE INTERACTION WITH FIBRIN, PLASMINOGEN AND LOW MOLECULAR WEIGHT LIGANDS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644613.

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Tissue-type plasminogen activator (t-PA) activates the proenzyme plasminogen to the active protease plasmin which degrades fibrin. The unique properties of t-PA, fibrin binding and stimulation of activity by fibrin make it an interesting molecule for specific thrombolysis. t-PA is thought to consist of five structural regions designated finger (F), growth factor (G), kringle 1 (Kl), kringle 2 (K2) and protease (P). Previous studies have shown that the interaction of t-PA with fibrin is mediated by the F and K2 regions.Mutated t-PA cDNA molecules were expressed in Chinese hamster ovary cells an

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Petrioli, Nello, and Brandon Eastwood. "London Expanding - Adding Value Through Fine Engineering." In IABSE Congress, New York, New York 2019: The Evolving Metropolis. International Association for Bridge and Structural Engineering (IABSE), 2019. http://dx.doi.org/10.2749/newyork.2019.2699.

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<p>London combines a rapidly expanding population with ever-decreasing land availability. This equation continues to attract property investors and allows developers to deliver high quality buildings.</p><p>Typically, developments must respect local site constraints. London’s rich construction archaeology – from Roman times to the post-war period – and the need to future-proof new infrastructure, create a unique blend of challenging constraints.</p><p>Unlocking such highly constrained sites by devising finely-engineered, sustainable and cost-efficient solutions ha

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Abe, Masamitsu, Joichi Murakami, and Naoto Shinmura. "Ultrasonic Testing and Photographic Imaging System for Tube to Tubesheet Weld of Heat Exchanger." In ASME 2017 Pressure Vessels and Piping Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/pvp2017-65569.

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This paper describes non-destructive testing systems that were constructed to inspect tube-to-tubesheet welds of a heat exchanger operating in a chemical plant such as urea products. A phased array ultrasonic testing system inserts a testing device into the tube, rotates it and scans the tube-to-tubesheet welds, thereby detecting any weld defects that are not only parallel to a tube axis but also in any direction, and displaying the size and location of the defects on a computer screen using system software. These welds have conventionally been inspected by liquid penetrant testing and visual

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Luntovskyy, Andriy, Stefan Uhlig, and Alexander Schill. "Candy site finder, a planning tool for wireless networks." In 2008 18th International Crimean Conference "Microwave & Telecommunication Technology" (CriMiCo 2008). IEEE, 2008. http://dx.doi.org/10.1109/crmico.2008.4676412.

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Oh, Jung S., Dean Q. Lewis, Daeyong Lee, and Gary A. Gabriele. "JAVA™-Based Design Calculator for Integral Snap-Fits." In ASME 1999 Design Engineering Technical Conferences. American Society of Mechanical Engineers, 1999. http://dx.doi.org/10.1115/detc99/cie-9075.

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Abstract Many different types of snap-fits have been developed to replace conventional fasteners, and research efforts have been made to characterize their performance. It is often tedious to look for design equations for unique types of snap-fits to calculate the insertion and retention forces. If found, these equations tend to be long, complex, and difficult to use. For this reason, a snap-fit calculator has been created to help in designing integral attachment features. Studies of seven most commonly used snap-fits (annular snap, bayonet-and-finger, cantilever hook, cantilever-hole, compres

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Song, Zhigang, Pat McGinnis, Dave Albert, et al. "Electrical Probing Role in 14nm SOI Microprocessor Failure Analysis." In ISTFA 2020. ASM International, 2020. http://dx.doi.org/10.31399/asm.cp.istfa2020p0061.

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Abstract Failure analysis plays a very important role in semiconductor industry. Photon Emission Microscopy (PEM) has been extensively used in localization of fails in microelectronic devices. However, PEM emission site is not necessarily at the location of the defect. Thus, it has limitation for the success rate of the follow-up physical failure analysis focusing on the emission site. As semiconductor technology advanced in the 3D FinFET realm and feature size further shrank down, the invisible defects during SEM inspection are tremendously increased. It leads to the success rate further decr

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Reports on the topic "A-site finger"

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Pelletier, Austin, Amanda Hohner, Idil Deniz Akin, et al. Bench-scale Electrochemical Treatment of Co-contaminated Clayey Soil. Illinois Center for Transportation, 2021. http://dx.doi.org/10.36501/0197-9191/21-018.

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Industrial soil contamination is frequently unearthed by transportation agencies during construction within the right-of-way. As a result, transportation agencies may experience construction delays. Soils co-contaminated with high-molecular-weight polycyclic aromatic hydrocarbons (HMW-PAHs) and metals are commonly encountered in Illinois and exhibit recalcitrance towards conventional treatment technologies. This issue is exacerbated in the fine-grained soils common to Illinois, where low-permeability and immense sorption capacity increase treatment complexity, cost, and duration. Contaminated

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Akinleye, Taiwo, Idil Deniz Akin, Amanda Hohner, et al. Evaluation of Electrochemical Treatment for Removal of Arsenic and Manganese from Field Soil. Illinois Center for Transportation, 2021. http://dx.doi.org/10.36501/0197-9191/21-019.

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Soils containing inorganic compounds are frequently encountered by transportation agencies during construction within the right-of-way, and they pose a threat to human health and the environment. As a result, construction activities may experience project delays and increased costs associated with management of inorganic compounds containing soils required to meet environmental regulations. Recalcitrance of metal-contaminated soils toward conventional treatment technologies is exacerbated in clay or organic content-rich fine-grained soils with low permeability and high sorption capacity becaus

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Last, G. V., M. A. Glennon, M. A. Young, and G. W. Gee. Protective barrier materials analysis: Fine soil site characterization: A research report for Westinghouse Hanford Company. Office of Scientific and Technical Information (OSTI), 1987. http://dx.doi.org/10.2172/5598007.

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Brophy, Kenny, and Alison Sheridan, eds. Neolithic Scotland: ScARF Panel Report. Society of Antiquaries of Scotland, 2012. http://dx.doi.org/10.9750/scarf.06.2012.196.

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The main recommendations of the Panel report can be summarised as follows: The Overall Picture: more needs to be understood about the process of acculturation of indigenous communities; about the Atlantic, Breton strand of Neolithisation; about the ‘how and why’ of the spread of Grooved Ware use and its associated practices and traditions; and about reactions to Continental Beaker novelties which appeared from the 25th century. The Detailed Picture: Our understanding of developments in different parts of Scotland is very uneven, with Shetland and the north-west mainland being in particular nee

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