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Dissertations / Theses on the topic 'A transdermal therapeutic system'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Jalal, Ahmed Hasnain. "Multivariate Analysis for the Quantification of Transdermal Volatile Organic Compounds in Humans by Proton Exchange Membrane Fuel Cell System." FIU Digital Commons, 2018. https://digitalcommons.fiu.edu/etd/3886.

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In this research, a proton exchange membrane fuel cell (PEMFC) sensor was investigated for specific detection of volatile organic compounds (VOCs) for point-of-care (POC) diagnosis of the physiological conditions of humans. A PEMFC is an electrochemical transducer that converts chemical energy into electrical energy. A Redox reaction takes place at its electrodes whereas the volatile biomolecules (e.g. ethanol) are oxidized at the anode and ambient oxygen is reduced at the cathode. The compounds which were the focus of this investigation were ethanol (C2H5OH) and isoflurane (C3H2ClF5O), but th

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2

Membrino, Michael A. "Transdermal delivery of therapeutic compounds by iontophoresis." [Gainesville, Fla.] : University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE1000142.

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Thesis (Ph. D.)--University of Florida, 2002.<br>Title from title page of source document. Document formatted into pages; contains xvii, 283 p.; also contains graphics. Includes vita. Includes bibliographical references.

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3

Roxhed, Niclas. "A Fully Integrated Microneedle-based Transdermal Drug Delivery System." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4484.

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4

Magnus, Ashley Denis. "Aspects of the bioavailability of topical corticosteroid formulations." Thesis, Rhodes University, 2013. http://hdl.handle.net/10962/d1009516.

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Two possible variables of the McKenzie/Stoughton blanching assay, namely amount applied to the test site and occlusion time have been investigated. Subsequently, two topical steroid preparations, Synalar cream (0,025% fluocinolone acetonide) and Betnovate cream (0,1% betamethasone 17-valer ate) were extemporaneously diluted with five and six placebo bases respectively. Taking cognizance of the two possible variables, these diluted preparations were assessed in vivo using a modified version of the McKenzie/Stoughton blanching assay for blanching activity over a 14 month period. It was found tha

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5

Zeng, Jianming. "Constrained crystallization and depletion in the polymer medium for transdermal drug delivery system." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5102.

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Transdermal drug delivery systems (TDS) are pharmaceutical devices that are designed to deliver specific drugs to the human body by diffusion through skin. The TDS effectiveness suffers from crystallization in the patch when they are kept in storage for more than two years. It has been reported that there are two types of crystals in the patch: needle and aggregate, and growth of drug crystals in TDS generally occurs only in the middle third of the polymer layer. In our study, fluorescence microscopy, EDS (SEM) and Raman microspectroscopy were used to further characterize the crystals. The res

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6

Coetzee, Hanneri. "The transdermal delivery of arginine vasopressin with pheroid technology / H. Coetzee." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1491.

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7

Busquets, Garcia Arnau 1985. "Targeting the endocannabinoid system for therapeutic purposes." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/119617.

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The endocannabinoid system is an endogenous neuromodulatory system that regulates a plethora of physiological functions, including the modulation of memory, anxiety, pain, synaptic plasticity and neuronal excitability, among others. The activation of this system through exogenous or endogenous cannabinoid agonists has been proposed as a therapeutic strategy in different pathological states, although an important caveat to their use is the possible central adverse effects, such as memory impairment, anxiety and tolerance. The activity of the endocannabinoid system has been recently found involv

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8

Van, Dyk Christina Petronella. "Transdermal delivery of 5-Fluorouracil with PheroidTM technology / C.P. van Dyk." Thesis, North-West University, 2008. http://hdl.handle.net/10394/1905.

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9

Van, der Walt Magdalena Elizabeth. "Transdermal delivery of Acyclovir and Ketoconazole by PheroidTM technology / Magdalena Elizabeth van der Walt." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1937.

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10

Vettorato, Elisa. "Development of transdermal delivery systems for innovative clinical applications of cannabinoids." Doctoral thesis, Università degli studi di Padova, 2019. http://hdl.handle.net/11577/3422356.

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The use of cannabis for medicinal purposes is deeply rooted in history, dating back to ancient times. While there has been a strong push for legalizing medicinal cannabis and research, conclusive evidence regarding the short- and long-term health effects (harms and benefits) of cannabis use remains elusive because of a high variability when cannabinoids are administered orally or by inhalation. Transdermal delivery of cannabinoids could allow a constant, defined release of these active ingredients. The main goal of this project was to develop innovative pharmaceutical forms in order to ensure

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11

Heffner, Ned Thomas. "Development of a Robotic System for Quantitative Therapeutic Massage." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1276266128.

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12

Houston, David. "Towards a nanomedicine-based broad-spectrum topical virucidal therapeutic system." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/15524/.

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The health benefits of the fruit of Punica granatum (pomegranate) have been recognised for many centuries. This thesis tested the hypothesis that a potent novel antimicrobial system could be developed based upon the activity of pomegranate rind extract (PRE), particularly when combined with a potentiating agent, and focussed on studying activity against Herpes simplex virus, types 1 and 2 (HSV-1 and HSV-2). High potentiated virucidal action of PRE against HSV-1 was observed when ferrous sulphate (FeSO4) was added; however, this activity diminished rapidly and also gave rise to an unsightly bla

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13

Sokka, Shunmugavelu D. (Shunmugavelu Doraivelu) 1975. "Cavitation methods in therapeutic ultrasound : techniques, mechanisms, and system design." Thesis, Massachusetts Institute of Technology, 2003. http://hdl.handle.net/1721.1/28597.

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Thesis (Ph. D.)--Harvard-MIT Division of Health Sciences and Technology, February 2004.<br>Includes bibliographical references (leaves 134-151).<br>Focused ultrasound is currently being developed as a non-invasive thermal ablation technique for benign and cancerous tumors in several organ systems. Although these therapies are designed to ablate tissue purely by thermal means, cavitation, the formation and collapse of gas bubbles, can occur. These bubbles can be unpredictable in their timing and location and often interfere with thermal therapies. Therefore, focused ultrasound techniques have t

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14

Udosen, Inyang Udofia. "Development of assays for therapeutic screening in myotonic dystrophy." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/14282/.

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Myotonic dystrophy (DM) is an autosomal dominant inherited multisystemic neuromuscular disease. The molecular mechanism for DM is mediated by toxic RNAs containing expanded repeat units. DMI is caused by a CTG repeat expansion in 3'-UTR of the DMPK gene while DM2 is caused by CCTG repeat in intronl of the ZNF9 gene. The molecular features of DM are formation of RNA foci, co-localisation of MBNL proteins with ribonuclear foci, splicing defects of a subset of pre-mRNAs with elevation ofCUGBPI in DMl. In order to develop therapy for DM, assays were designed based on the molecular characteristics

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15

Coll, Miró Marina. "Therapeutic role of IL-‐37 after injury to the nervous system." Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/317960.

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La lesió de medul·la espinal és una de les principals causes de mortalitat entre pacients menors de 50 anys. Es dona en una taxa d’entre 20-‐40 persones per milió d’habitants i amb una major prevalença en homes que en dones (amb una ratio de 4:1). A diferència del sistema nerviós perifèric (SNP), el sistema nerviós central (SNC) de mamífers adults presenta una limitada capacitat de regeneració espontània fet que porta a una pèrdua de dèficits funcionals permanents. Això és degut en part a: la escassa capacita

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16

Vase, Hollie Francesca. "Interrogating therapeutic manipulation of the endocannabinoid system in the human colon." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=203798.

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The endocannabinoid system (ECS) is known to be involved in key aspects of cell maintenance within the human colon, as well as being dysregulated in pathophysiological conditions, including colon inflammation and cancer. However, the contribution of the ECS within each of these conditions has not been fully elucidated. This indicates that the current identification of key targets within the ECS that are involved in gut pathology could be used as potential novel therapeutics. Two experimental approaches were designed and optimised to give an insight into ECS signal regulation within the human c

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17

Nair, Amit. "Development of a targeted diagnostic and therapeutic delivery system for cholangiocarcinoma." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16791/.

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The current outcomes of peri-hilar cholangiocarcinoma (PH-CCA) are in general poor with no proven roles for any treatment modalities in improving survival apart from complete surgical extirpation. The dismal prognosis observed is contributed to by both delays in diagnosis and aggressive tumour biology. The advent of molecular targeting of solid cancers allows harnessing this property on microbubble and nanotechnology based platforms. Such a system provides for concurrent diagnosis and therapeutic effect (theragnosis), the feasibility of which is explored in this work. The expression of two can

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18

Bittner, Olin J. "Designing a Data-Tracking System for a Private Therapeutic Day School." Antioch University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1448896028.

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19

Neupane, Rabin. "Percutaneous absorption and Skin accumulation of ABH Carbopol gel in Porcine Ear Skin." University of Toledo Health Science Campus / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=mco1556641636092785.

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20

Sewell, William Arthur Carrock. "Intracellular cytokines and their therapeutic modulation in immunological disorders." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325461.

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21

Stewart, Simon. "Optimising therapeutic efficacy in acute and chronic cardiac disease states /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phs851.pdf.

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22

Anglin, Lewis Leon. "A cognitive behavioral therapeutic approach to a Christian African American family system." Theological Research Exchange Network (TREN), 2006. http://www.tren.com/search.cfm?p068-0584.

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23

Hyatt, Alexander James Thompson. "Fibrin gel as a delivery system for drugs, therapeutic proteins, and cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609541.

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24

Yant, Stephen Russell. "Sleeping beauty : a DNA transposon system for therapeutic gene transfer in vertebrates /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5068.

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25

BARISON, Erika. "Pichia pastoris: an eukariotic system for the expression of recombinant therapeutic molecules." Doctoral thesis, Università degli Studi di Verona, 2010. http://hdl.handle.net/11562/343912.

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L’ideazione di farmaci antitumorali che riconoscono recettori o antigeni della superficie cellulare, come le Immunotossine, rappresentano un approccio promettente per il trattamento di pazienti affetti da cancro. La capacità di indurre l’apoptosi dell’Immunotossina IL4PE40 deriva dal frammento di 40 kDa della tossina PE (Pseudomonas esotossina A) e la sua specificità dalla forma permutata dell’interleuchina-4. IL4PE40 prodotta da E. coli è estratta dai corpi d’inclusione e purificata nella sua forma attiva tramite cromatografia di affinità. Comunque, la translazione clinica di molecole terapeu

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26

Fang, Zhi You. "Mechanisms and therapeutic implications of diabetic heart disease /." [St. Lucia, Qld], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18240.pdf.

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27

Sherret, John, and Joshua Coleman. "Small Cell Medullary Thyroid Cancer: A Therapeutic Dilemma." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/57.

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Small cell variant of medullary thyroid carcinoma is an extremely rare histologic entity with a paucity of data. As such, there is a lack of clinical experience regarding this disease. In this case, a 52-year-old patient with small cell variant medullary thyroid carcinoma was experiencing intractable nausea, vomiting, and diarrhea. The initial workup was extensive yet unrevealing. He was refractory to all treatments. On further laboratory analysis, the calcitonin was substantially high and the thyroid stimulating hormone level was mildly elevated. This case is presented to highlight a possible

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28

Silverman, Sanford, Robert B. Raffa, Marc Cataldo, Monica Kwarcinski, and Steven R. Ripa. "Use of immediate-release opioids as supplemental analgesia during management of moderate-to-severe chronic pain with buprenorphine transdermal system." DOVE MEDICAL PRESS LTD, 2017. http://hdl.handle.net/10150/624646.

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Background: The buprenorphine transdermal system (BTDS) is approved in the US for the management of chronic pain. Due to its high affinity for mu-opioid receptors with a slow dissociation profile, buprenorphine may potentially displace or prevent the binding of competing mu-opioid-receptor agonists, including immediate-release (IR) opioids, in a dose-dependent manner. Health care professionals may assume that the use of IR opioids for supplemental analgesia during BTDS therapy is not acceptable. Materials and methods: This post hoc analysis evaluated the use of IR opioids as supplemental analg

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29

Poirier, Denise Marie. "Nutrient absorption from liquid therapeutic diets in an animal model." Thesis, McGill University, 1988. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61694.

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30

Yang, Xiaojuan. "Development of Nanoparticle Systems for Therapeutic Drug Delivery." The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1248972068.

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31

Policastro, Megan A. "Therapeutic jurisprudence and the importance of drug courts in the juvenile justice system." Honors in the Major Thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1129.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Health and Public Affairs<br>Legal Studies

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32

Gerrard, Stephen Edmund. "A novel infant therapeutic delivery system for drugs, nutrients and anti-viral agents." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648462.

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33

Naik, Sweta. "Design of control release drug delivery system (DDS) for imaging and therapeutic applications." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2606.

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The main challenge in disease treatment is no more the discovery of new therapeutic drugs, but to provide targeted delivery of therapeutic drugs to specific sites without incurring systemic toxicity effects. An efficient way of reducing the toxicity is by encapsulating the drug with a biodegradable matrix that can provide controlled release of the drug along with local heating of the drug. Local heating can be obtained by incorporating magnetic iron oxide particles that heat upon exposure to AC electromagnetic fields. The magnetic iron oxide nanoparticles are also gaining much attention as M

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34

Philp, Christopher J. "The potential therapeutic effect of manipulating the extracellular matrix in idiopathic pulmonary fibrosis." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/35802/.

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Background: Idiopathic Pulmonary Fibrosis (IPF) is a physiologically devastating disease. The debilitating nature and high mortality rates make this one of the most lethal conditions, usually associated with median time to mortality of around 3 years. Increased deposition of extracellular matrix (ECM) and fibroblast accumulation are hallmarks of idiopathic pulmonary fibrosis (IPF). We hypothesise that the ECM in IPF is structurally abnormal by virtue of aberrant cross linking and promotes fibroblast accumulation. This study examined the structure and biological activity of IPF derived ECM and

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35

Riaz, Muhammad Kashif. "Peptide functionalized drug delivery system for an efficient lung cancer therapy." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/609.

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Lung cancer has a high incidence rate globally and the leading cause of cancer related mortalities. In 2018, lung cancer has been estimated to cause 1.76 million deaths worldwide (18.33% of total cancer mortalities). In Hong Kong lung cancer has been a leading cause of cancer related deaths, and in 2016 caused 3780 deaths (26.6% of total cancer mortalities). Non-small cell lung cancer (NSCLC) is the major (~85%) lung cancer type, and five-year survival rate for lung cancer has estimated to be 18%. Thus, an efficient lung cancer treatment with lesser adverse effects is need of the hour. In this

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36

Au, Wai Ling. "Investigations of the bioavailability/bioequivalence of topical corticosteroid formulations containing clobetasol propionate using the human skin blanching assay, tape stripping and microdialysis." Thesis, Rhodes University, 2010. http://hdl.handle.net/10962/d1003221.

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Currently, clinical trials in patients are required by most regulatory authorities for the assessment of bioequivalence of topical products where the drug is not intended for systemic absorption. Hence there is a dire need for suitable methods for the assessment of bioavailability and bioequivalence of such products since clinical safety and efficacy studies are expensive, time-consuming and require very large numbers of patients. Except for topical corticosteroid products where the human skin blanching assay/vasoconstrictor assay has been approved by the US FDA for bioequivalence assessment o

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37

Schielke, Hugo Josef. "Systemic Alliance and Progress in Individual Therapy: The Influence of Indirect Client System Alliance on Process and Progress in Individual Therapy." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1385655060.

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38

Lansdell, Casey. "Characterization of Surgery-Induced Vaccine Dysfunction in a Therapeutic Murine Melanoma Model." Thesis, Université d'Ottawa / University of Ottawa, 2016. http://hdl.handle.net/10393/34269.

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Surgical resection is the leading treatment of most solid tumours, however surgical stress creates an immunosuppressive environment that promotes metastases. A global decrease in T cell numbers and function post-surgery has been documented. However, the effect on tumour associated antigen (TAA)-specific T cells remains unclear. The objective is therefore to evaluate the impact of surgical stress on TAA-specific adaptive T cell immunity. Melanoma tumour-bearing C57BL/6 mice were vaccinated using AdhDCT, an adenovirus expressing dopochrome totaumerase (DCT), a melanoma TAA, and underwent abdomin

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39

Wilkin, Linda Diane. "Rehabilitative influence of therapeutic ultrasound treatment on cellular markers of skeletal muscle regeneration following blunt contusion injury /." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486463321624146.

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40

Gray, Warren Dale. "Development of therapeutic systems to treat the infarcted heart." Diss., Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/53429.

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Cardiovascular disease is the leading cause of morbidity and mortality in developed nations, and heart disease is predicted to remain the leading killer for the foreseeable future. Acute myocardial infarctions—nearly 1.1 million annually occurring in the U.S. alone—are the major cardiovascular disease subgroup. Current treatments for myocardial infarction are limited to interventions that serve to mitigate the initial insult, but clinical applications to protect or regenerate damaged myocardium are lacking. This dissertation examines three therapeutic systems to treat the infarcted heart. Firs

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41

Navarro, Romero Alba 1990. "Role and therapeutic potential of the endocannabinoid system in animal models of intellectual disability." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665798.

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Intellectual disability encompasses several neurodevelopmental disorders characterized by impairments in cognitive and adaptive functioning with onset during the developmental period. Currently, treatment of intellectual disability is restricted to early intervention programs and individualized education, which have limited efficacy. Several preclinical studies indicate that intellectual disability may be improved by pharmacological interventions. This thesis is focused on the role and therapeutic potential of the endocannabinoid system in intellectual disability disorders. The relevance of th

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42

Tam, Pui-see Patricia, and 談沛詩. "Developing an in vivo reporter system for the monitoring of therapeutic effects on neuroblastoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B42905230.

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43

Webber, Daniel. "Therapeutic potential of transplanted neural progenitor cells following injury to the central nervous system." Thesis, King's College London (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439085.

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44

Peron, Jean-Marie. "Quantitative structure activity relationship analysis of anti-oxidants with central nervous system therapeutic potential." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271327.

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Jevans, B. S. "Biology and therapeutic potential of enteric nervous system stem cells for spinal cord injury." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10039531/.

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Spinal cord injury (SCI) is one of the leading and most crippling causes of acquired neurological impairment. It affects around 40,000 individuals in the UK, causing paralysis, multisystem impairment and a reduced life expectancy. This has a devastating impact on quality of life and places stress upon both individuals and healthcare systems. Despite extensive characterization of SCI pathology, there remains no cure. Stem cells offer a potential therapy since they can replace lost neurons, promote axonal regeneration and limit scar formation, but an optimal stem cell source has yet to be found.

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Morris, Stacy J. 1974. "A shoe-integrated sensor system for wireless gait analysis and real-time therapeutic feedback." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/28601.

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Thesis (Sc. D.)--Harvard-MIT Division of Health Sciences and Technology, 2004.<br>Includes bibliographical references (p. 307-314).<br>Clinical gait analysis currently involves either an expensive analysis in a motion laboratory, using highly accurate, if cumbersome, kinematic systems, or a qualitative analysis with a physician or physical therapist making visual observations. There is a need for a low cost device that falls in between these two methods, and can provide quantitative and repeatable results. In addition, continuous monitoring of gait would be useful for real-time physical rehabi

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Powis, Rachael Anita. "Targeting the ubiquitin proteasome system to develop novel therapeutic approaches for spinal muscular atrophy." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25854.

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Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disorder characterised by lower motor neuron degeneration and paralysis. Although it is a leading genetic cause of childhood death no approved treatment options currently exist. As SMA is caused by low levels of the survival motor neuron (SMN) protein the majority of therapeutic strategies under development are therefore aimed at trying to elevate SMN levels. However, a number of limitations with these approaches exist demonstrating a need for the investigation of SMN-independent therapeutics. Of these non-classical pathways, the

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48

Hernandez, Joseph. "A PRELIMINARY STUDY ON EXTERNAL COUNTERPULSATION SYSTEM: AN ALTERNATIVE THERAPEUTIC OPTION FOR FONTAN PATIENTS." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3825.

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In order to address the long-term complications that arise from poor venous return, a hallmark of the Fontan physiology, we assessed the feasibility of a non-invasive, home therapy that will improve the health of the patient during the heart transplant waiting period and ameliorate the quality of life. In order to achieve this goal we tested a device that applies pressure to the lower extremities of the body (legs and abdomen) in a pulsating fashion with the goal of augmenting systemic blood flow to the pulmonary arteries. This treatment will enhance flow from the great veins and through the l

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49

Tam, Pui-see Patricia. "Developing an in vivo reporter system for the monitoring of therapeutic effects on neuroblastoma." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B42905230.

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50

Valdez, Glenn R. "Restoration of homeostasis within the stress system : a novel therapeutic approach for alcohol dependence /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC IP addresses, 2003. http://wwwlib.umi.com/cr/ucsd/fullcit?p3112199.

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