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Journal articles on the topic 'A transdermal therapeutic system'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Sahu, Mithlesh, Mithun Bhowmick, and Jagdish Rathi. "Design and evaluation of Matrix Transdermal therapeutic system of Repaglinide." International Journal of Research and Development in Pharmacy & Life Sciences 06, no. 04 (2017): 2697–705. http://dx.doi.org/10.21276/ijrdpl.2278-0238.2017.6(4).2697-2705.

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Sidorov, Aleksander V. "TRANSDERMAL FENTANYL: PHARMACOLOGICAL ASPECTS OF THERAPY IN CANCER PATIENTS. PART 1. FROM THE DEVELOPMENT OF TRANSDERMAL FENTANYL FORMULATIONS TILL META-ANALYSES OF CLINICAL TRIALS." Russian Journal of Oncology 22, no. 3 (2017): 122–30. http://dx.doi.org/10.18821/1028-9984-2017-22-3-122-130.

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There was given a review of data on pharmacology of fentanyl with focus on transdermal formulation. In the first part of the article improvements in technology of fentanyl transdermal patches were reviewed and advantages of the membrane-matrix system that are of practical use were highlighted. The results obtained from bioequivalence and therapeutic equivalence studies of traditional and improved transdermal fentanyl systems were given. Clinical trials with fentanyl transdermal patches as well as systematic reviews and meta-analyses on the efficacy and safety of transdermal fentanyl were summa

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3

ONO, HIDENORI, YUKA KIDA, HIROMI ONOMICHI, KENICHI MURAOKA, and KAKUJI TOJO. "Temporal Control of Transdermal Therapeutic System." KAGAKU KOGAKU RONBUNSHU 25, no. 2 (1999): 233–36. http://dx.doi.org/10.1252/kakoronbunshu.25.233.

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4

Sachin, Pawar* Nitin Sawle Dr. Gajanan Sanap. "Review On Transdermal Drug Delivery System." International Journal of Pharmaceutical Sciences 3, no. 1 (2025): 671–81. https://doi.org/10.5281/zenodo.14628391.

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Polymeric patches with dissolved or dispersed medication that continuously release therapeutic agents via the skin are known as transdermal drug delivery systems. Although transdermal administration has significantly advanced medical practice, it has not yet reached its full potential as a substitute for hypodermic injections and oral delivery. The idea behind TDDS is that they can deliver drugs continuously over an extended length of time, which will maintain the drug's concentration in plasma. To maintain plasma-drug levels for therapeutic efficacy, TDDS can be made to input drugs at the rig

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5

Kuznetsova, E. G., V. A. Ryzhikova, L. A. Salomatina, O. M. Kuryleva, and V. I. Sevastianov. "Percutaneous delivery system for nicotinamide transdermal therapeutic system." Perspektivnye Materialy 7 (2023): 46–56. http://dx.doi.org/10.30791/1028-978x-2023-7-46-56.

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Recently, antioxidants, one of which is nicotinamide, have often been used in the treatment of a number of chronic cardiovascular, autoimmune, skin diseases, and diabetes mellitus. Taking into account the frequent and long-term use of nicotinamide, it seems appropriate to the authors to create a new dosage form of a transdermal therapeutic system (TTS) capable of maintaining the required level of the drug concentration in the blood for a long time. The aim of the work was to develop and to study the functional properties of a system for percutaneous delivery of nicotinamide in vitro. Four comp

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Manthal, Aishwarya, Dr Sunayana Ghodgaonkar, Akash S. Nalawade, and Shivani B.Masal. "Recent Advancement in Transdermal Drug Delivery System." International Journal of Pharmaceutical Research and Applications 09, no. 06 (2024): 1320–29. https://doi.org/10.35629/4494-090613201329.

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The transdermal route offers several advantages over traditional drug delivery methods. These include high bioavailability, avoidance of first-pass liver metabolism, consistent drug levels in the bloodstream, and a non-invasive approach to treatment. Furthermore, transdermal drug delivery systems (TDDS) offer prolonged therapeutic effects, fewer side effects, enhanced bioavailability, improved patient adherence, and easy discontinuation of therapy. TDDS is used not only in pharmaceuticals but also in skincare and cosmetics. Research has shown that the transdermal route causes minimal skin irri

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7

Samiksha B. Rotake, Pooja R. Hatwar, Ravindra L. Bakal, and Nitin B. Kohale. "Transdermal drug delivery system recent advancements: A comprehensive review." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 059–72. http://dx.doi.org/10.30574/gscbps.2024.28.2.0269.

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"The transdermal route offers numerous benefits when compared to traditional drug delivery methods. These advantages encompass high bioavailability, the absence of first-pass hepatic metabolism, maintaining consistent drug plasma levels, and the non-invasive nature of therapy. Additionally, transdermal drug delivery systems [TDDS] provide prolonged therapeutic effects, reduced side effects, enhanced bioavailability, improved patient compliance, and easy termination of drug therapy. TDDS finds applications not only in pharmaceuticals but also in the skincare and cosmetics industries. Studies ha

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8

Samiksha, B. Rotake, R. Hatwar Pooja, L. Bakal Ravindra, and B. Kohale Nitin. "Transdermal drug delivery system recent advancements: A comprehensive review." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 059–72. https://doi.org/10.5281/zenodo.14676299.

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"The transdermal route offers numerous benefits when compared to traditional drug delivery methods. These advantages encompass high bioavailability, the absence of first-pass hepatic metabolism, maintaining consistent drug plasma levels, and the non-invasive nature of therapy. Additionally, transdermal drug delivery systems [TDDS] provide prolonged therapeutic effects, reduced side effects, enhanced bioavailability, improved patient compliance, and easy termination of drug therapy. TDDS finds applications not only in pharmaceuticals but also in the skincare and cosmetics industries. Studies ha

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Plezia, P. M., J. LinforrI, T. H. Kramer, R. P. lacono, and S. R. Hamcroff. "TRANSDERMAL THERAPEUTIC SYSTEM (FENTANYL) FOR POSTOPERATIVE PAIN." Anesthesiology 65, Supplement 3A (1986): A211. http://dx.doi.org/10.1097/00000542-198609001-00210.

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10

COMFORT, A. "Enhanced transport in a therapeutic transdermal system." Biomaterials 11, no. 9 (1990): 729–33. http://dx.doi.org/10.1016/0142-9612(90)90036-p.

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11

Tipre, Dnyanesh N., and Pradeep R. Vavia. "Acrylate-Based Transdermal Therapeutic System of Nitrendipine." Drug Development and Industrial Pharmacy 29, no. 1 (2003): 71–78. http://dx.doi.org/10.1081/ddc-120016685.

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12

Qi, Guorong, Yunsong Yang, Shilin Yang, Guolin Zhang, and Qingdi Zhang. "Study on the Niclosamide Transdermal Therapeutic System." Chinese Journal of Applied Chemistry 14, no. 4 (1997): 25–28. http://dx.doi.org/10.3724/j.issn.1000-0518.1997.4.25.

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13

Pranay, Sanjay Bafana, Javesh K. Patil Dr., and S. Hasni Hamid. "Breaking Barriers: Advancements in Transdermal Drug Delivery for Enhanced Therapeutic Efficacy." Journal of Advancement in Immunology 1, no. 2 (2024): 60–71. https://doi.org/10.5281/zenodo.12156679.

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<em>The use of transdermal drug delivery has significantly improved medical procedures. The transdermal drug delivery system (TDDS) is a method of delivering a drug's active ingredient through the skin, improving the drug's therapeutic efficacy and safety while also reducing size and dose.  As a cutting-edge tool for controlled release, TDDS attracted a lot of interest. Drugs enter the body through the skin in this type of TDDS, bypassing the first pass metabolism and entering the systemic circulation instead. The dosage form for TDDS is made up of patches. Transdermal patches penetrate t

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Niranjan D. Waghmare, Kanchan A. Hiwe, Kanchan A. Hiwe, Pooja R. Hatwar, Supriya S. Barewar, and Purva P. Bhoyar. "Transdermal drug delivery system: A tool for NDDS." GSC Biological and Pharmaceutical Sciences 30, no. 2 (2025): 179–94. https://doi.org/10.30574/gscbps.2025.30.2.0039.

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Transdermal drug delivery system (TDDS) specializes to explore new methods that can efficiently and painlessly transmit better molecules in therapeutic quantity to overcome the difficulties allied with oral route, namely poor bioavailability due to first pass metabolism and receptiveness to produce rapid blood level. Transdermal drug delivery gets improved the therapeutic effectiveness and security of drugs by more site-specific way but spatial and temporal placement within body is necessary to reduce both the size and number of doses essential to achieve the objective of systemic medication t

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15

Drasti, Pandya*1 Taufik Mulla2. "Advancements In Transdermal Drug Delivery System: A Comprehensive Overview." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 147–75. https://doi.org/10.5281/zenodo.11453521.

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Transdermal drug delivery system (TDDS) is a novel strategy in pharmaceutical research that provides a patient-friendly, non-invasive way to deliver therapeutic drugs. This abstract offers a summary of the most important developments in transdermal drug delivery technology, emphasizing their possible effects on healthcare. Nanotechnology has played a pivotal role, enabling the development of novel drug carriers that enhance permeation through the skin barrier. These nanocarriers, such as liposomes and polymeric nanoparticles, facilitate the controlled release of drugs, improving therapeutic ef

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16

Samata, Korgaonkar* Gauri Bhivshet Vijay Jagtap. "An Overview of Transdermal Drug Delivery System (TDDS)." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2132–42. https://doi.org/10.5281/zenodo.14482112.

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Oral medications often fall short of desired efficacy. To address this limitation, transdermal drug delivery systems (TDDS) have emerged as a viable alternative. TDDS involve delivering drugs through the skin to achieve systemic effects, differing from traditional topical applications. These systems transport drugs to viable skin tissues, producing local therapeutic effects while also releasing a significant fraction into systemic circulation. The adhesive used in TDDS plays a crucial role in ensuring product safety, efficacy, and quality. Transdermal delivery offers several advantages over tr

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17

Swapnil, More *. Akash Inde Abhishek Jadhav Ashishkumar Jadhav. "RECENT ADVANCES IN TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS): AN OVERVIEW." Journal of Pharma Research 8, no. 5 (2019): 346–53. https://doi.org/10.5281/zenodo.3236719.

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<strong><em>ABSTRACT</em></strong> <strong><em>C</em></strong><em>onventional dosage form has significant setbacks of poor bioavailability and frequent dosing due to hepatic first pass metabolism</em><em>.</em><em> Transdermal drug delivery systems (TDDS), dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. It is (TDDS) also known as “patches,” are. In order to deliver therapeutic agents through the human skin for systemic effects, the comprehensive morphological, biophysical and physicochemical properties of the skin are to be

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18

Uzdenova, Indira, and Camila Musaeva. "Use of transdermal therapeutic systems for endocrine diseases." Vrač skoroj pomoŝi (Emergency Doctor), no. 6 (June 1, 2020): 24–32. http://dx.doi.org/10.33920/med-02-2006-01.

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Transdermal therapeutic system (TTS) is a new generation of dosage forms when a drug substance enters the body through the skin, and then gets into the bloodstream. The advantages and disadvantages of this dosage form are known. Transdermal drug delivery has great prospects, is easy to prescribe, convenient for elderly patients. TTSs came out on top among highly effective systems of drug delivery through the skin. To date, this dosage form is not widespread in Russia.

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19

Kuznetsova, E. G., V. A. Ryzhikova, L. A. Salomatina, O. M. Kuryleva, and V. I. Sevastianov. "A Percutaneous Delivery System for a Nicotinamide Transdermal Therapeutic System." Inorganic Materials: Applied Research 15, no. 2 (2024): 336–43. http://dx.doi.org/10.1134/s2075113324020291.

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20

Sayali, shankhapal* Vaishnavi pandav Rutuja jaiswal Sonali kalam. "Transdermal Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 8 (2024): 3570–80. https://doi.org/10.5281/zenodo.13354827.

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Transdermal drug delivery systems, or TDDSs, are adhesive patches applied to the skin with a precise dosage that are then absorbed into the bloodstream. It is important to take into account the entire morphological, biophysical, and physicochemical aspects of the skin when delivering medicinal substances through the human skin for systemic effects. A transdermal patch offers a regulated release and continuous drug administration, which is advantageous over other forms of pharmaceutical delivery. It also avoids pulsed entry into the systemic circulation, which frequently results in undesirable

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21

Dharmeh, Trivedi, and Goyal Anju. "Pros and Cons of Transdermal Drug Delivery System." Pharmaceutical and Chemical Journal 7, no. 4 (2020): 53–60. https://doi.org/10.5281/zenodo.13955283.

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Transdermal drug delivery is having variety of benefits over traditional drug delivery systems and has increased patient compliance. Transdermal patches are easy application on skin and removal as and when required. TDDS deliver drugs for systemic effects at a predetermined and controlled rate over an extended period of time in order to enhance the therapeutic effectiveness and reduce adverse effect of the drug. TDDS helps in maintaining the concentration of drug within the therapeutic window range for extended time period ensuring that drug levels should not fall below the minimum effective c

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22

Madhuri, D. Sahane*1 Maya Y. Gaikwad2 Divya S. Gaikar3. "Spray: Film Forming System Promising As Transdermal Drug Delivery System." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 294–309. https://doi.org/10.5281/zenodo.10931631.

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Transdermal drug delivery systems offer numerous advantages over conventional routes, including improved patient compliance and reduced systemic side effects. Spray-on film forming systems (SFFS) have emerged as a novel and versatile approach for delivering drugs through the skin. This abstract presents an overview of SFFS technology, highlighting its potential in transdermal drug delivery. SFFS formulations consist of a solution or suspension of drug molecules and polymers, which upon spraying onto the skin, form a thin, uniform film that adheres to the application site. This film acts as a r

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23

Bajpai, Sharad, Kanchan Butola, and Vijaylaxmi Bisht. "Recent Advancement on TDDS (Transdermal Drug Delivery System)." Journal for Research in Applied Sciences and Biotechnology 1, no. 5 (2022): 59–67. http://dx.doi.org/10.55544/jrasb.1.5.6.

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The creation of a transdermal drug delivery system (TDDS) has been one of the most sophisticated and innovative approaches to drug delivery. The transdermal drug delivery system has attracted considerable attention because of its many potential advantages, including better patient compliance, avoidance of gastrointestinal disturbances, hepatic first-pass metabolism, and sustained delivery of drugs to provide steady plasma profiles, particularly for drugs with short half-lives, reduction in systemic side effects and enhanced therapeutic efficacy. This review article covers a brief outline of th

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Prof., Madhuri T. Deshmukh Harshada A. Lawale *. Prof. R.V. Shete Prof. R.S. Solunke. "A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM." Journal of Pharma Research 7, no. 12 (2018): 279–82. https://doi.org/10.5281/zenodo.2085047.

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<strong><em>ABSTRACT</em></strong> <strong><em>R</em></strong><em>ecently delivery of drugs through the skin is being a challenging area for research because of barrier properties exhibit    by the outermost layer of skin stratum corneum. The transdermal drug delivery system has offers significant clinical benefits over other dosage forms. Because transdermal drug delivery offers controlled and predetermined rate of release of the drug into the patient, it able to maintain steady state blood concentration in blood stream. It is essential form of drug delivery due to absolute adv

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25

Prakash Raj K, Rajakarthikeyan U, Saranraj L, Sivakumar L, R. Yuvhraj, and Buvaneshvaran K. "A small review on recent advances in transdermal drug delivery system." Indian Journal of Pharmacy and Pharmacology 11, no. 1 (2024): 10–16. http://dx.doi.org/10.18231/j.ijpp.2024.003.

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Transdermal drug delivery devices (TDDS), often known as "patches," are dosage forms designed to transfer a therapeutically effective amount of medicine over a patient's skin. Transdermal distribution establishes one of the most important channels for a revolutionary medication delivery method. Transdermal drug delivery has various advantages over traditional delivery methods, such as oral and injection; however, its efficacy is restricted. Transdermal administration traditionally entails pushing a patch containing a medicinal substance onto the skin, which is both convenient and painless, as

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Gamón, ER, JDlC Oyanguren, AP Ferriols, and JMF Baixauli. "Contact Dermatitis from Nitroglycerin in a Transdermal Therapeutic System." Acta Dermato-Venereologica 86, no. 6 (2006): 544–45. http://dx.doi.org/10.2340/00015555-0146.

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27

Chiang, Chiao-Hsi, Jiin-Long Chen, Yu-Tien Liu, and Da-Peng Wang. "Therapeutic Effect and Pharmacokinetics of Ketotifen Transdermal Delivery System." Drug Development and Industrial Pharmacy 24, no. 3 (1998): 213–17. http://dx.doi.org/10.3109/03639049809085612.

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28

Burris, J. F. "The USA experience with the clonidine transdermal therapeutic system." Clinical Autonomic Research 3, no. 6 (1993): 391–96. http://dx.doi.org/10.1007/bf01829459.

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29

Bo¨hme, K. "Buprenorphine in a Transdermal Therapeutic System – A New Option." Clinical Rheumatology 21, S1 (2002): S13—S16. http://dx.doi.org/10.1007/s100670200031.

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30

Vishnupriya, Nagam, Yerikala Ramesh, Venugopalaiah Penabaka, and Yadala Prapurna Chandra. "Microneedles in transdermal drug delivery system." International Journal of Clinical Pharmacokinetics and Medical Sciences 5, no. 1 (2025): 20–35. https://doi.org/10.26452/ijcpms.v5i1.706.

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One such review paper focuses on Minnesota's advanced technologies, highlighting the latest updates on drug delivery methods, challenges, and innovations. Intravenous therapy, a non-invasive and pain-free approach, is often used for drug delivery. This method offers a complete bioactivity with minimal intrusion, enabling the administration of medication through the skin. The effectiveness of this treatment is influenced not only by the transdermal delivery system but also by profiling, which helps optimize the release of active ingredients.The paper discusses various components of intravenous

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Kuznetsova, E. G., V. A. Ryzhikova, L. A. Salomatina, V. A. Tukmachev, and V. I. Sevastianov. "MICRONEEDLES AS A WAY TO INCREASE THE TRANSDERMAL INSULIN DELIVERY." Russian Journal of Transplantology and Artificial Organs 18, no. 4 (2017): 87–92. http://dx.doi.org/10.15825/1995-1191-2016-4-87-92.

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Aim: to prove the possibility of increasing the diffusion of insulin through the skin in vitro with pre-applying microneedles.Materials and methods. Microemulsion for transdermal therapeutic system of insulin has been used in vitro studies. Genetically engineered human insulin has been used in this research. Applicators with silicon microneedles (40 and 150 microns long) have been used to enhance the diffusion fl ux of drug substance. The dynamics of insulin release from the transdermal therapeutic systems through the rabbit skin has been studied in glass Franz diffusion cells in analyzer diff

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Yarmolinskaya, M. I., L. Yu Karakhalis, and S. A. Cherkashina. "Results of the Russian observational study EFFECTICARE on transdermal contraception." Voprosy ginekologii, akušerstva i perinatologii 23, no. 5 (2024): 98–110. https://doi.org/10.20953/1726-1678-2024-5-98-110.

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Modern contraceptive methods provide effective prevention of abortion and contribute significantly to women’s reproductive health. Combined oral contraceptives are the most popular form of reversible hormonal contraception. However, they have several disadvantages, which necessitates the search for new, more convenient and controllable methods. One such method is the transdermal therapeutic system. Objective. To study the short- and long-term risks of using a transdermal contraceptive patch (norelgestromin 6 mg + ethinyl estradiol 0.6 mg) in reproductive-aged women who have a need for birth co

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Musel, Andrea L., and Erin M. Warshaw. "Cutaneous Reactions to Transdermal Therapeutic Systems." Dermatitis 17, no. 3 (2006): 109–22. http://dx.doi.org/10.2310/6620.2006.05051.

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Bershow, Andrea, and Erin Warshaw. "Cutaneous Reactions to Transdermal Therapeutic Systems." Dermatitis 22, no. 4 (2011): 193–203. http://dx.doi.org/10.2310/6620.2011.10135.

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Hikima, T., K. Tojo, and H. I. Maibach. "Skin Metabolism in Transdermal Therapeutic Systems." Skin Pharmacology and Physiology 18, no. 4 (2005): 153–59. http://dx.doi.org/10.1159/000085860.

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36

Cunningham, Glenn R. "Testosterone Replacement With Transdermal Therapeutic Systems." JAMA 261, no. 17 (1989): 2525. http://dx.doi.org/10.1001/jama.1989.03420170069032.

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Rutik, Kachare Ulka Mote. "A Review Article on Novel Transdermal Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1316–28. https://doi.org/10.5281/zenodo.14220788.

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Transdermal Drug Delivery System is controlled medicated that is set on the skin to deliver a particular Portion of medicine through the skin and into the circulatory system. It is likewise significant because of its Interesting benefit such as less absorption, more uniform plasma levels, improved bioavailability, decrease Side effect, efficacy and quality of the product. Transdermal dose structures may give clinicians a chance to Offer more therapeutic alternatives to their patients to upgrade their consideration. For thousands of years, human civilizations have applied substances to the skin

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Bhumi, Patel* Dr. Chainesh Shah. "FABRICATION AND IN-VITRO CHARACTERIZATION OF TRANSDERMAL MATRIX PATCH OF KETOPROFEN FOR TRANSDERMAL THERAPEUTIC SYSTEM." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 960–73. https://doi.org/10.5281/zenodo.153859.

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Objective: The objective of research work was to improve the permeability of Ketoprofen and to provide controlled release of drug to provide maximum effective concentration. Experimental work: Transdermal drug delivery systems are polymeric patches containing dissolved or dispersed drugs that deliver therapeutic agents at a constant rate to the human skin. Matrix type transdermal patches containing Ketoprofen were prepared by solvent casting method employing aluminium foil method. Polyethylene glycol (PEG) 400 was used as plasticizer and Dimethyl sulfoxide (DMSO) was used as penetration enhanc

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Cada, Dennis J., Terri L. Levien, and Danial E. Baker. "Granisetron Transdermal System." Hospital Pharmacy 44, no. 4 (2009): 332–39. http://dx.doi.org/10.1310/hpj4404-332.

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Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing inservices. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent in print and are also available online. Monographs can be customized to meet the needs of a facility. S

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Yee, Lisa Y., and Julio R. Lopez. "Transdermal Fentanyl." Annals of Pharmacotherapy 26, no. 11 (1992): 1393–99. http://dx.doi.org/10.1177/106002809202601113.

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OBJECTIVE: To review the use of transdermal fentanyl for the treatment of moderate to severe chronic pain. The article provides background on the pharmacology and pharmacokinetics of the drug, as well as the properties of the transdermal system. In addition, clinical trials, adverse effects, and therapeutic considerations and recommendations are presented. DATA SOURCES: Clinical trials, review articles, and reference texts. STUDY SELECTION: Comparative clinical trials involving the use of transdermal fentanyl on postoperative and chronic pain patients. DATA EXTRACTION: Data from clinical human

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Cada, Dennis J., Terri Levien, and Danial E. Baker. "Rotigotine Transdermal System." Hospital Pharmacy 42, no. 10 (2007): 939–50. http://dx.doi.org/10.1310/hpj4210-939.

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Each month, subscribers to The Formulary Monograph Service receive five to six well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to your Pharmacy and Therapeutics Committee. Subscribers also receive monthly one-page summary monographs on the agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation (DUE) is also provided each month. With a subscription, the monographs are sent to you in print and CD-ROM forms and are available online. Monographs can be customized t

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Paarth Saini, Raj Kumar Mandal, Anshita Dubey, and Rahul Pal. "Recent Advances in Transdermal Drug Delivery Systems." Journal of Pharma Insights and Research 2, no. 6 (2024): 087–97. https://doi.org/10.69613/p3cspw10.

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Transdermal drug delivery systems (TDDS), particularly transdermal patches, represent a significant advancement in pharmaceutical technology, offering non-invasive drug administration through the skin. These systems provide controlled release mechanisms and improved therapeutic outcomes. The evolution of TDDS has effectively addressed various limitations of conventional drug delivery methods, by escaping first-pass metabolism and maintaining steady plasma drug concentrations. Technological innovations have introduced sophisticated materials and formulation strategies, including advanced polyme

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Dr., D. Rama Brahma Reddy* D. Tejaswi K. Hima Sankar K. Venkatesh G. Trinath Babu V. Suresh B. Upendra Naik. "An Overview on Preparation Methods and Evaluation of Transdermal Patches." International Journal of Pharmaceutical Sciences 2, no. 12 (2024): 2337–49. https://doi.org/10.5281/zenodo.14505870.

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Transdermal drug delivery systems (TDDS), also known as “patches,” are dosage forms designed to deliver a therapeutically effective amount of drug across a patient’s skin. In order to deliver therapeutic agents through the human skin for systemic effects, Transdermal delivery provides a leading edge over injectables and oral routes by increasing patient compliance and avoiding first pass metabolism respectively. With the advancement in technology Pharma industries have trendified all its resources. Earlier we use convectional dosage form but now we use novel drug delivery sys

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S, Subramanian, and Senith SK. "Formulation and evaluation of Clopidogrel bisulfate loaded transdermal patches for anti-platelet activity." International Journal of Research in Pharmaceutical Sciences 9, no. 1 (2018): 25. http://dx.doi.org/10.26452/ijrps.v9i1.1153.

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Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Orally clopidogrel bisulfate has a short elimination half-life (7-8 h), low oral bioavailability (50 %) undergoes extensive first pass metabolism (85 %) and frequent high doses (75 mg) are required to maintain the therapeutic level as a result. The purpose of this research was formulation and evaluation of transdermal drug delivery system of clopidogrel bisulfate using various polymers such as HPMC and EC by solvent casting technique for improvement of

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Kuznetsova, E. G., O. M. Kuryleva, L. A. Salomatina, et al. "On the possibility of therapeutic action after transdermal patch application." Russian Journal of Transplantology and Artificial Organs 24, no. 2 (2022): 119–24. http://dx.doi.org/10.15825/1995-1191-2022-2-119-124.

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Background. As scientific knowledge about the peculiarities of the structure and functional properties of the skin increased, it became clearer that during transdermal administration, drug may accumulate in the deep layers of the dermis and subsequently get diffused into the bloodstream even after the transdermal therapeutic system (TTS), also called transdermal patch, had been removed. Objective: to quantify active drug substances remaining in an animal skin after TTS application. Materials and methods. Two previously developed transdermal patches containing Russian-made drug substances were

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Gaurav, P. Aswar, R. Hatwar Pooja, L. Bakal Ravindra, S. Kalamb Vaishnavi, and K. Thak Ishar. "Microneedles: An efficient technique to enhance Transdermal Drug Delivery System." GSC Biological and Pharmaceutical Sciences 29, no. 3 (2024): 256–66. https://doi.org/10.5281/zenodo.14915541.

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Microneedle technology has emerged as a promising tool for enhancing transdermal drug delivery. This technology involves the use of micron-sized needles to create microchannels in the skin, allowing for the delivery of drugs, vaccines, and other therapeutic agents. The skin's outermost layer, the stratum corneum, is the primary barrier to drug penetration, and microneedles have been shown to effectively bypass this barrier. Various types of microneedles have been developed, including solid, coated, dissolving, and hollow microneedles, each with its own advantages and disadvantages. Microneedle

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Aasim, Shaikh Jameel1* Majaz A. Qazi2 Shaikh Aatif Jameel3. "A Review On Preparation And Evaluation Of Targeted Transdermal Drug Delivery System In The Treatment Of Migraine." International Journal in Pharmaceutical Sciences 2, no. 4 (2024): 915–24. https://doi.org/10.5281/zenodo.11046325.

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Transdermal patches distribute the medication through the skin in a precise and controlled manner, hence enhancing the medication's therapeutic efficacy. Triptan is a second-generation triptan with a good tolerance profile and higher patient satisfaction. The aim of the present work was to formulate and evaluate transdermal patches of Triptan. For the current study, the transdermal patch containing drug with different ratios of polymeric combinations and varying plasticizer concentration were prepared. The patch was fabricated by solvent evaporation method. An array of biological, physiologica

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Kharia, A., R. Gilhotra, and A. K. Singhai. "Overview of Transdermal Medicated Patches with its research updates in preceding years." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 1094–102. http://dx.doi.org/10.22270/jddt.v9i3-s.2962.

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Innovations in transdermal drug delivery systems (TDDS) is an important influence to medical practice by providing advances in the delivery of treatment with existing conventional drugs and novel drugs. Transdermal drug delivery is one of the most promising methods for drug application. It has several benefits over conventional system to offer sustained drug release, avoidance of first pass effect, patient compliance, ease of application and removal in case of toxicity as well as decrease in the side effects as compared with conventional therapy. Transdermal patches are dosage forms which tran

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Isowaki, Akiharu, Akira Ohtori, Yumi Matsuo, and Kakuji Tojo. "Drug Delivery to the Eye with a Transdermal Therapeutic System." Biological & Pharmaceutical Bulletin 26, no. 1 (2003): 69–72. http://dx.doi.org/10.1248/bpb.26.69.

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Quirce, S., A. Garde, G. Baz, P. Gonzalez Dra María, and Dolores Alonso Díaz de Durana. "Allergic contact dermatitis from estradiol in a transdermal therapeutic system." Allergy 51, no. 1 (1996): 62–63. http://dx.doi.org/10.1111/j.1398-9995.1996.tb04554.x.

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