Relevant bibliographies by topics / A2780 cells

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  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'A2780 cells'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "A2780 cells"

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Oliveira, Carolina G., Isolda Romero-Canelón, Monize M. Silva, et al. "Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors." Dalton Transactions 48, no. 44 (2019): 16509–17. http://dx.doi.org/10.1039/c9dt02570g.

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Tang, Hao, Ping Gong, Ling Tao, and Yurong Hua. "miR-194 Inhibits Ovarian Cancer Cell Proliferation and Reduces Cisplatin Resistance by Targeting Yes-Associated Protein." Journal of Biomaterials and Tissue Engineering 10, no. 8 (2020): 1170–75. http://dx.doi.org/10.1166/jbt.2020.2379.

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Elevated expression of Yes-associated protein (YAP1) is associated with ovarian cancer. Bioinformatics analysis showed a relationship between miR-194 and YAP1. Our study intends to assess whether miR-194 regulates YAP1 expression and affects the proliferation of ovarian cancer cells and CDDP resistance. CDDP-resistant cell line A2780/CDDP was established and the expression of miR-194 and YAP1 in parental A2780 cells and normal ovarian epithelial IOSE80 cells were compared. A2780/CDDP cells were separated into miR-NC group and miR-194 mimic group followed by analysis of miR-194 and YAP1 express
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I-Ju, Lin, and Tian YongJie. "MiR-624-5p enhances cell resistance against cisplatin via PDGFRA/Stat3/PI3K axis in ovarian cancer." Tropical Journal of Pharmaceutical Research 19, no. 4 (2020): 691–98. http://dx.doi.org/10.4314/tjpr.v19i4.3.

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Purpose: The purpose of this study was to evaluate the role of miR-624-5p in ovarian cancer.Methods: MiR-624-5p expression in ovarian cancer {OC) cell lines and normal cells (NCs) was evaluated and compared the differential miR-624-5p in OC A2780 cells and cisplatin-resistant OC cell line (A2780/DDP). CCK-8 was used to evaluate changes in cell viability of the A2780 and A2780/DDP cell lines as well as silenced miR-624-5p. Western Blot examined the Stat3 and phosphorylated Pi3k. The binding between PDGFRA and miR-624-5p was predicted on Targetscan and verified through Luciferase Reporter Assay.
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Fahrenholtz, Cale D., Jessica Swanner, Maria Ramirez-Perez, and Ravi N. Singh. "Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin." Journal of Nanomaterials 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5107485.

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We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell lines (A2780, SKOV3, and OVCAR3). We found that AgNPs were highly cytotoxic toward A2780 and SKOV3 cells but OVCAR3 cells were less sensitive to AgNPs. In agreement with the cytotoxicity data, AgNPs caused DNA damage in A2780 and SKOV3 cells, but not in OVCAR3 cells. A2780 and SKOV3 showed higher levels of basal reactive oxygen species (ROS) relative to OVCAR3 cells. AgNP exposure increased ROS levels in both A2780 and SKOV3 cells, but not in OVCAR3 cells. We found that the heterogeneous cytotoxicit
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Lee, Heejin, Oh-Bin Kwon, Jae-Eon Lee, et al. "Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells." Cells 10, no. 4 (2021): 918. http://dx.doi.org/10.3390/cells10040918.

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The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies targeting ovarian CSCs are needed to overcome the limitations of present treatments. This study evaluated the effect of trimebutine maleate (TM) targeting ovarian CSCs, using A2780-SP cells acquired by a sphere culture of A2780 epithelial ovarian cancer cells. TM is indicated as a gastrointestinal motility modulator and is known to as a periphe
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Ruibin, Jiang, Cheng Guoping, Zheng Zhiguo, et al. "Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line." BioMed Research International 2018 (June 25, 2018): 1–9. http://dx.doi.org/10.1155/2018/3972534.

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Ovarian cancer leads the worst prognosis among all types of gynecologic malignancies, and patients are often diagnosed at an advanced stage. Ovarian cancer also has a high rate of metastasis; however, the detailed mechanisms for ovarian cancer prone to metastasis remain unclear. In this study, we used continuous in vitro screening of the human ovarian cancer A2780 cell line to establish a cell line (A2780-M) which shows high invasiveness and motility. Compared to the parental cells, A2780-M cells express elevated protein levels of CD44, CD133, CD34, andβ-catenin. A2780-M cells are also more re
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Ahn, Ji-Hye, Jeong-Hwa Woo, Jung-Rae Rho, and Jung-Hye Choi. "Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo." Marine Drugs 17, no. 2 (2019): 126. http://dx.doi.org/10.3390/md17020126.

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Gukulenin A is a bis-tropolone tetraterpenoid isolated from the marine sponge Phorbas gukhulensis. In this study, we examined the anticancer activities of gukulenin A in ovarian cancer cell lines (A2780, SKOV3, OVCAR-3, and TOV-21G) and in an ovarian cancer mouse model generated by injecting A2780 cells. We found that gukulenin A suppressed tumor growth in A2780-bearing mice. Gukulenin A markedly inhibited cell viability in four ovarian cancer cell lines, including the A2780 cell line. Gukulenin A treatment increased the fraction of cells accumulated at the sub G1 phase in a dose-dependent man
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Zheng, Lei, Li Li, Yun Lu, Fangfang Jiang, and Xiu-An Yang. "SREBP2 contributes to cisplatin resistance in ovarian cancer cells." Experimental Biology and Medicine 243, no. 7 (2018): 655–62. http://dx.doi.org/10.1177/1535370218760283.

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This study is to investigate transcription factors involved in cisplatin resistance in ovarian cancer cells. The transcriptome of cisplatin resistant and sensitive A2780 epithelial ovarian cancer cells was obtained from GSE15372. Ovarian transcriptome data GSE62944 was downloaded from TCGA and applied for transcription regulatory network analysis. The analysis results were confirmed using quantitative polymerase chain reaction. The roles of SREBP2 in cisplatin-resistant cells were investigated by RNA inference and cell viability analysis. Transcription regulatory network analysis found that 12
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Ruibin, Jiang, Jin Bo, Wan Danying, Zhu Chihong, Feng Jianguo, and Gu Linhui. "Therapy Effects of Wogonin on Ovarian Cancer Cells." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/9381513.

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Background. Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells and show inhibitory effect on cancer cell growth. However, the detailed and underlying molecular mechanisms are not elucidated. In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. Materials and Methods. We determined the effects of wogonin on the changes of cell cycling and apoptotic responses of cells. Western blot analysis was used to measure the effects of wogonin on protein expressions. Results. Our results showed that treatm
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Abdalla, Ashraf N., Usama Shaheen, Qasem M. A. Abdallah, et al. "Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells." Molecules 25, no. 7 (2020): 1582. http://dx.doi.org/10.3390/molecules25071582.

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Among the hundreds of reported Achillea species, A. membranacea (Labill.) DC. is one of the six that grow in Jordan. Many species of this genus are used in folk medicine to treat a variety of ailments and several biological and pharmacological activities have been ascribed to their essential oil (EO). For this study, the EO obtained from a specimen of A. membranacea grown in Jordan was analyzed by GC-MS. Ninety-six compounds were detected, of which oxygenated monoterpenes was the predominant class (47.9%), followed by non-terpene derivatives (27.9%), while sesquiterpenes represented 14.2% of t
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Dissertations / Theses on the topic "A2780 cells"

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English, Michael Joseph. "The role of Glutathione in Cisplatin and 60Co c-radiation resistance in A2780 and A2780 cp cells /." Thesis, McGill University, 1998. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21549.

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A Cisplatin-resistant subline of a Human Ovarian cancer cell line, A2780 CP also exhibits cross resistance to 60Co gamma-radiation. Cellular Glutathione (GSH) levels were measured by the Tietze Spectrophotometric method. GSH levels in A2780 CP cells were approximately three time that of the parental A2780 cells. In cells depleted of GSH by L-Buthionine Sulfoximine (BSO), Cisplatin-resistance was significantly decreased in both cell lines. BSO had no effect on the radiation resistance of either cell lines. However treatment of cells with a combination of BSO and Dimethyl Fumarate (DMF) signific
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English, Michael Joseph. "The role of Glutathione in Cisplatin and §6§0 Co ã-radiation resistance in A2780 and A2780 [superscript] C [superscript] P cells." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0026/MQ50764.pdf.

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Saker, Lina. "Modifications de la structure des télomères des cellules cancéreuses par le cis-platine." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05P623.

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Les télomères sont des structures nucléoprotéiques localisées aux extrémités des chromosomes. Ils jouent un rôle important dans le maintien de l’information génétique, la stabilité et la protection des extrémités chromosomiques. Les télomères sont composés de séquences d’ADN répétées riches en guanines (TTAGGG) et des protéines télomériques qui les protègent. Parmi celles-ci, TRF1 et TRF2 se fixent directement sur le double brin. Toute modification de la structure des télomères (composition en protéines télomériques, raccourcissement de leur longueur, dommages) peut entrainer la mort des cellu
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Ng, Siaw Wei. "Calcium signalling in immune cells." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b3843e43-9503-4855-a280-35c0d28f65e6.

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Inappropriate stimulation of mast cells can trigger allergies including asthma, allergic rhinitis and eczema which, combined, affect almost 30% of the population in western societies. Mast cell activation begins with aggregation of IgE receptors in response to antigen. This then triggers a series of reactions resulting in the tyrosine phosphorylation of Syk kinase, PKC activation and ultimately both degranulation and secretion of leukotrienes and cytokines. CRAC channels are expressed on mast cells, and are essential for IgE-mediated mast cell activation. Previous work in our laboratory has sh
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Startzman, Ashley N. "Inhibition of stat3 protein as an approach to sensitizing ovarian cancer cells to cisplatin." Honors in the Major Thesis, University of Central Florida, 2008. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/1143.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Medicine<br>Molecular Biology and Microbiology
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Thornton, Kate. "Enzyme triggered self-assembled peptide derivative hydrogels for embryonic stem cell culture." Thesis, University of Manchester, 2010. https://www.research.manchester.ac.uk/portal/en/theses/enzyme-triggered-selfassembled-peptide-derivative-hydrogels-for-embryonic-stem-cell-culture(0e60f1f1-2638-4a01-a280-10263d2b8703).html.

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Aromatic peptide amphiphiles that self-assemble in response to a trigger, such as pH or enzymes, have the ability to support the culture of somatic cell types, in both two-dimensional (2D) and three-dimensional (3D) culture. Although a fully defined synthetic substrata is required for the successful clinical applications of Embryonic Stem (ES) cells hydrogels of SA aromatic peptide amphiphiles have not been investigated for this purpose. The aim of this investigation is to produce alkaline phosphatase (AP) triggered hydrogels as a substratum for ES cell culture. This SA trigger was chosen as i
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LIN, JUN-MAO, and 林俊茂. "Isolation and characterization of human ovarian carcinoma A2780 cell resistant to VM-26, a topoisomerase II-targeting drug." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/65550258170309238664.

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Conference papers on the topic "A2780 cells"

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Amable, Lauren, Kenji Kudo, Elaine Gavin, Jason Fain, and Eddie Reed. "Abstract LB-223: A specific Isoform of Gli1 binds the promoter region of c-fos in A2780-CP70 human ovarian cancer cells." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-lb-223.

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Kudo, Kenji, Elaine Gavin, Shamik Das, et al. "Abstract LB-281: Inhibition of Hedgehog results in altered regulation of c-jun and of ERCC1 in cisplatin-resistant A2780-CP70 human ovarian cancer cells." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-lb-281.

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Fredenburgh, J. C., D. Collen, and M. E. Nesheim. "Enhancement by Activated Protein C of tPA-induced Lysis in a Cell-free System." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644379.

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The profibrinolytic activity of human activated protein C (APC) was studied in a cell-free system using human plasma. Normal and Ba+* citrate adsorbed human plasmas were dialyzed against 150mM NaCl, 20mM Hepes, pH 7.4 and diluted to an A280 of 16. Reactions were initiated by the addition of aliquots of plasma to cuvettes containing human melanoma tPA and human thrombin at final concentrations of 1 and 30nM, respectively. The effects of Ca+* and varying concentrations of APC on clotlysis times were examined by monitoring turbidity at 600nM while maintaining the temperature at 37°C. The lysis ti
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