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Journal articles on the topic 'A2780 cells'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Oliveira, Carolina G., Isolda Romero-Canelón, Monize M. Silva, et al. "Palladium(ii) complexes with thiosemicarbazones derived from pyrene as topoisomerase IB inhibitors." Dalton Transactions 48, no. 44 (2019): 16509–17. http://dx.doi.org/10.1039/c9dt02570g.

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Tang, Hao, Ping Gong, Ling Tao, and Yurong Hua. "miR-194 Inhibits Ovarian Cancer Cell Proliferation and Reduces Cisplatin Resistance by Targeting Yes-Associated Protein." Journal of Biomaterials and Tissue Engineering 10, no. 8 (2020): 1170–75. http://dx.doi.org/10.1166/jbt.2020.2379.

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Elevated expression of Yes-associated protein (YAP1) is associated with ovarian cancer. Bioinformatics analysis showed a relationship between miR-194 and YAP1. Our study intends to assess whether miR-194 regulates YAP1 expression and affects the proliferation of ovarian cancer cells and CDDP resistance. CDDP-resistant cell line A2780/CDDP was established and the expression of miR-194 and YAP1 in parental A2780 cells and normal ovarian epithelial IOSE80 cells were compared. A2780/CDDP cells were separated into miR-NC group and miR-194 mimic group followed by analysis of miR-194 and YAP1 express

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I-Ju, Lin, and Tian YongJie. "MiR-624-5p enhances cell resistance against cisplatin via PDGFRA/Stat3/PI3K axis in ovarian cancer." Tropical Journal of Pharmaceutical Research 19, no. 4 (2020): 691–98. http://dx.doi.org/10.4314/tjpr.v19i4.3.

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Purpose: The purpose of this study was to evaluate the role of miR-624-5p in ovarian cancer.Methods: MiR-624-5p expression in ovarian cancer {OC) cell lines and normal cells (NCs) was evaluated and compared the differential miR-624-5p in OC A2780 cells and cisplatin-resistant OC cell line (A2780/DDP). CCK-8 was used to evaluate changes in cell viability of the A2780 and A2780/DDP cell lines as well as silenced miR-624-5p. Western Blot examined the Stat3 and phosphorylated Pi3k. The binding between PDGFRA and miR-624-5p was predicted on Targetscan and verified through Luciferase Reporter Assay.

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Fahrenholtz, Cale D., Jessica Swanner, Maria Ramirez-Perez, and Ravi N. Singh. "Heterogeneous Responses of Ovarian Cancer Cells to Silver Nanoparticles as a Single Agent and in Combination with Cisplatin." Journal of Nanomaterials 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/5107485.

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We investigated the effects of silver nanoparticle (AgNP) exposure in three ovarian cancer cell lines (A2780, SKOV3, and OVCAR3). We found that AgNPs were highly cytotoxic toward A2780 and SKOV3 cells but OVCAR3 cells were less sensitive to AgNPs. In agreement with the cytotoxicity data, AgNPs caused DNA damage in A2780 and SKOV3 cells, but not in OVCAR3 cells. A2780 and SKOV3 showed higher levels of basal reactive oxygen species (ROS) relative to OVCAR3 cells. AgNP exposure increased ROS levels in both A2780 and SKOV3 cells, but not in OVCAR3 cells. We found that the heterogeneous cytotoxicit

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Lee, Heejin, Oh-Bin Kwon, Jae-Eon Lee, et al. "Repositioning Trimebutine Maleate as a Cancer Treatment Targeting Ovarian Cancer Stem Cells." Cells 10, no. 4 (2021): 918. http://dx.doi.org/10.3390/cells10040918.

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The overall five-year survival rate for late-stage patients of ovarian cancer is below 29% due to disease recurrence and drug resistance. Cancer stem cells (CSCs) are known as a major contributor to drug resistance and recurrence. Accordingly, therapies targeting ovarian CSCs are needed to overcome the limitations of present treatments. This study evaluated the effect of trimebutine maleate (TM) targeting ovarian CSCs, using A2780-SP cells acquired by a sphere culture of A2780 epithelial ovarian cancer cells. TM is indicated as a gastrointestinal motility modulator and is known to as a periphe

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6

Ruibin, Jiang, Cheng Guoping, Zheng Zhiguo, et al. "Establishment and Characterization of a Highly Metastatic Ovarian Cancer Cell Line." BioMed Research International 2018 (June 25, 2018): 1–9. http://dx.doi.org/10.1155/2018/3972534.

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Ovarian cancer leads the worst prognosis among all types of gynecologic malignancies, and patients are often diagnosed at an advanced stage. Ovarian cancer also has a high rate of metastasis; however, the detailed mechanisms for ovarian cancer prone to metastasis remain unclear. In this study, we used continuous in vitro screening of the human ovarian cancer A2780 cell line to establish a cell line (A2780-M) which shows high invasiveness and motility. Compared to the parental cells, A2780-M cells express elevated protein levels of CD44, CD133, CD34, andβ-catenin. A2780-M cells are also more re

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Ahn, Ji-Hye, Jeong-Hwa Woo, Jung-Rae Rho, and Jung-Hye Choi. "Anticancer Activity of Gukulenin A Isolated from the Marine Sponge Phorbas gukhulensis In Vitro and In Vivo." Marine Drugs 17, no. 2 (2019): 126. http://dx.doi.org/10.3390/md17020126.

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Gukulenin A is a bis-tropolone tetraterpenoid isolated from the marine sponge Phorbas gukhulensis. In this study, we examined the anticancer activities of gukulenin A in ovarian cancer cell lines (A2780, SKOV3, OVCAR-3, and TOV-21G) and in an ovarian cancer mouse model generated by injecting A2780 cells. We found that gukulenin A suppressed tumor growth in A2780-bearing mice. Gukulenin A markedly inhibited cell viability in four ovarian cancer cell lines, including the A2780 cell line. Gukulenin A treatment increased the fraction of cells accumulated at the sub G1 phase in a dose-dependent man

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Zheng, Lei, Li Li, Yun Lu, Fangfang Jiang, and Xiu-An Yang. "SREBP2 contributes to cisplatin resistance in ovarian cancer cells." Experimental Biology and Medicine 243, no. 7 (2018): 655–62. http://dx.doi.org/10.1177/1535370218760283.

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This study is to investigate transcription factors involved in cisplatin resistance in ovarian cancer cells. The transcriptome of cisplatin resistant and sensitive A2780 epithelial ovarian cancer cells was obtained from GSE15372. Ovarian transcriptome data GSE62944 was downloaded from TCGA and applied for transcription regulatory network analysis. The analysis results were confirmed using quantitative polymerase chain reaction. The roles of SREBP2 in cisplatin-resistant cells were investigated by RNA inference and cell viability analysis. Transcription regulatory network analysis found that 12

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Ruibin, Jiang, Jin Bo, Wan Danying, Zhu Chihong, Feng Jianguo, and Gu Linhui. "Therapy Effects of Wogonin on Ovarian Cancer Cells." BioMed Research International 2017 (2017): 1–8. http://dx.doi.org/10.1155/2017/9381513.

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Background. Wogonin is a plant monoflavonoid and has been reported to induce apoptosis of cancer cells and show inhibitory effect on cancer cell growth. However, the detailed and underlying molecular mechanisms are not elucidated. In this study, we investigated the molecular and biological effects of wogonin in human ovarian A2780 cancer cells. Materials and Methods. We determined the effects of wogonin on the changes of cell cycling and apoptotic responses of cells. Western blot analysis was used to measure the effects of wogonin on protein expressions. Results. Our results showed that treatm

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10

Abdalla, Ashraf N., Usama Shaheen, Qasem M. A. Abdallah, et al. "Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells." Molecules 25, no. 7 (2020): 1582. http://dx.doi.org/10.3390/molecules25071582.

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Among the hundreds of reported Achillea species, A. membranacea (Labill.) DC. is one of the six that grow in Jordan. Many species of this genus are used in folk medicine to treat a variety of ailments and several biological and pharmacological activities have been ascribed to their essential oil (EO). For this study, the EO obtained from a specimen of A. membranacea grown in Jordan was analyzed by GC-MS. Ninety-six compounds were detected, of which oxygenated monoterpenes was the predominant class (47.9%), followed by non-terpene derivatives (27.9%), while sesquiterpenes represented 14.2% of t

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11

Li, Fang, Sumei Niu, Jing Sun, et al. "EfficientIn VitroTRAIL-Gene Delivery in Drug-Resistant A2780/DDP Ovarian Cancer Cell Line via Magnetofection." Journal of Nanomaterials 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/484589.

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Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) presents great promise as an anticancer agent for human cancer therapy. In this study, a magnetofection agent (polyMAG-l000) was evaluated forin vitrodelivery of TRAIL gene towards drug-resistant A2780/DDP ovarian cancer cells. Transfection experiments showed that polyMAG-l000 was able to transfect A2780/DDP cellsin vitro, leading to a higher level of TRAIL gene expression in the presence of a static magnetic field as compared to other transfection agent, such as Lipofectamine 2000. TRAIL gene expression in the A2780/DDP cells was

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12

Sørensen, Belinda Halling, Unnur Arna Thorsteinsdottir, and Ian Henry Lambert. "Acquired cisplatin resistance in human ovarian A2780 cancer cells correlates with shift in taurine homeostasis and ability to volume regulate." American Journal of Physiology-Cell Physiology 307, no. 12 (2014): C1071—C1080. http://dx.doi.org/10.1152/ajpcell.00274.2014.

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Cisplatin resistance is a major challenge in the treatment of cancer and develops through reduced drug accumulation and an increased ability to avoid drug-induced cell damage, cell shrinkage, and hence initiation of apoptosis. Uptake and release of the semiessential amino acid taurine contribute to cell volume homeostasis, and taurine has been reported to have antiapoptotic effects. Here we find that volume-sensitive taurine release in cisplatin-sensitive [wild-type (WT)] human ovarian cancer A2780 cells is reduced in the presence of the phospholipase A2 inhibitor bromenol lactone, the 5-lipox

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13

Jiang, Ying, Jing Jiang, Haiqing Jia, Zhiwei Qiao, and Jingru Zhang. "Recovery of miR-139-5p in Ovarian Cancer Reverses Cisplatin Resistance by Targeting C-Jun." Cellular Physiology and Biochemistry 51, no. 1 (2018): 129–41. http://dx.doi.org/10.1159/000495169.

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Background/Aims: In platinum-based chemotherapy for ovarian cancer, acquired drug resistance is a frequent occurrence. Because recent studies have demonstrated that dysregulation of microRNAs (miRNAs) is partly responsible for the induction of acquired drug resistance in cancers, we hypothesized that correcting the dysregulation of key miRNAs would reverse the acquired resistance to platinum-based drugs in ovarian cancer. Methods: Cisplatin-resistant SKOV3 and A2780 ovarian cancer cell lines (SKOV3-R and A2780-R, respectively) were established by long-term exposure to cisplatin. MTT assays wer

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14

Zhiwei, Rao, Xia Songbai, and Han Qi. "5, 7-Dihalo-8-quinolinol complex inhibits growth of ovarian cancer cells via the downregulation of expression of Wip1." Tropical Journal of Pharmaceutical Research 19, no. 7 (2020): 1417–22. http://dx.doi.org/10.4314/tjpr.v19i7.12.

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Purpose: To assess the cytotoxic effect of 5, 7-dihalo-8-quinolinol complex (DHQ) on ovarian cancer cells, and the mechanism of action involved.Methods: DHQ-mediated changes in cell viability were determined using MTT assay, while apoptosis was analyzed with flow cytometry. The effect of DHQ on cell migration was determined using inverted microscopy, while its effect on invasiveness was assessed with Giemsa dyeing. FACS Caliburinstrumentation was employed for analyzing the effect of DHQ on the cell cycle. The protein expressions of Wip1 and P53 were assayed by western blotting.Results: DHQ ind

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15

Chen, Qiaoyun, Rong Qin, Yue Fang, and Hao Li. "Berberine Sensitizes Human Ovarian Cancer Cells to Cisplatin Through miR-93/PTEN/Akt Signaling Pathway." Cellular Physiology and Biochemistry 36, no. 3 (2015): 956–65. http://dx.doi.org/10.1159/000430270.

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Background: Berberine, a well-known component of the Chinese herbal medicine Huanglian, has wide range of biochemical and pharmacological effects, including antineoplastic effect, but the exact mechanisms remain unclear. The aim of the present study was to evaluate the potential chemo-sensitization effect of berberine in ovarian cancer cell line A2780. Methods: The expression of miR-93 was measure by RT-PCR. The target of miR-93 was confirmed by luciferase activity assay. Hoechst 33258 staining, Annexin V and PI double staining were used for apoptosis analysis. Results: In this study, we found

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Wang, Wenyu, Jihye Im, Soochi Kim, et al. "ROS-Induced SIRT2 Upregulation Contributes to Cisplatin Sensitivity in Ovarian Cancer." Antioxidants 9, no. 11 (2020): 1137. http://dx.doi.org/10.3390/antiox9111137.

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Cisplatin resistance remains a significant obstacle for improving the clinical outcome of ovarian cancer patients. Recent studies have demonstrated that cisplatin is an important inducer of intracellullar reactive oxygen species (ROS), triggering cancer cell death. Sirtuin 2 (SIRT2), a member of class III NAD+ dependent histone deacetylases (HDACs), has been reported to be involved in regulating cancer hallmarks including drug response. In this study, we aimed to identify the role of SIRT2 in oxidative stress and cisplatin response in cancer. Two ovarian cancer cell lines featuring different s

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Horiuchi, Akiko, Cuiju Wang, Norihiko Kikuchi, Ryosuke Osada, Toshio Nikaido, and Ikuo Konishi. "BRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 during Cisplatin Treatment in Ovarian Cancer Cells." Biomarker Insights 1 (January 2006): 117727190600100. http://dx.doi.org/10.1177/117727190600100007.

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BRCA1 is a tumor suppressor which plays a crucial role in the repair of DNA double-strand breaks, and its abnormality is responsible for hereditary ovarian cancer syndrome. It has recently been reported that reduced expression of BRCA1 is also common in sporadic ovarian carcinoma via its promoter hypermethylation, and that ovarian carcinoma patients negative for BRCA1 expression showed favorable prognosis. To address if BRCA1 expression plays a role in the chemotherapeutic response, we analyzed the effect of BRCA1 suppression on the sensitivity to cisplatin and paclitaxel in ovarian cancer cel

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18

Chen, Pingping, Huibing Wang, Meng Li, et al. "6,12-Diphenyl-3, 9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate Inhibits Proliferation, Migration and Promotes Apoptosis in Ovarian Cancer Cells." Disease Markers 2020 (September 3, 2020): 1–9. http://dx.doi.org/10.1155/2020/5068067.

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6,12-Diphenyl-3,9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate (DDTC) has been synthesized by the photodimerization of 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate. The potential of theercvantitumor activity and mechanism were investigated in vitro using MTT assay in human lung cancer cell line A549, ovarian cancer cell lines SKOV3 and A2780, breast cancer cell line MCF-7, gastric cancer cell line BGC-823, colon cancer cell line HT29, prostate cancer cell line DU145, and liver cancer cell line SMMC7721. The results show that DDTC can inhibit the growth of ovarian cancer SKOV3 and A2780 ce

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Garrido, Maritza P., Carolina Vera, Margarita Vega, Andrew F. G. Quest, and Carmen Romero. "Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ovarian cancer cells and endothelial cells." Therapeutic Advances in Medical Oncology 10 (January 1, 2018): 175883591877098. http://dx.doi.org/10.1177/1758835918770984.

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Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it promotes proliferation as well as survival and is considered a proangiogenic factor. Metformin, a drug commonly used in the treatment of diabetes, is attributed to antineoplastic effects, but the underlying mechanisms remain unknown. Given that current therapies yield modest results in EOC patients, the aim of this study was to determine the effects of metformin on NGF-enhanced proliferation of EOC cel

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Liu, Xinfeng, Ying Yu, Jinna Zhang, et al. "HDAC1 Silencing in Ovarian Cancer Enhances the Chemotherapy Response." Cellular Physiology and Biochemistry 48, no. 4 (2018): 1505–18. http://dx.doi.org/10.1159/000492260.

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Background/Aims: Cisplatin-based treatment is first-line chemotherapy for several cancers including ovarian cancer. The development of cisplatin resistance results in treatment failure, but the underlying mechanisms are not fully understood. Histone deacetylases (HDACs) are a large family of enzymes that deacetylate lysine residues on histones and non-histone proteins. High expression of HDAC1 is associated with poor outcomes in ovarian cancer. Furthermore, resistance to chemotherapeutic agents is associated with HDAC1 overexpression in ovarian cancer cells. The goals of this study were to det

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Lee, Dahae, Seoung Rak Lee, Ki Sung Kang, et al. "Betulinic Acid Suppresses Ovarian Cancer Cell Proliferation through Induction of Apoptosis." Biomolecules 9, no. 7 (2019): 257. http://dx.doi.org/10.3390/biom9070257.

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Ovarian cancer is one of the leading causes of cancer deaths worldwide in women, and the most malignant cancer among the different gynecological cancers. In this study, we explored potentially anticancer compounds from Cornus walteri (Cornaceae), the MeOH extract of which has been reported to show considerable cytotoxicity against several cancer cell lines. Phytochemical investigations of the MeOH extract of the stem and stem bark of C. walteri by extensive application of chromatographic techniques resulted in the isolation of 14 compounds (1–14). The isolated compounds were evaluated for inhi

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Tang, Jian-ming, Jie Min, Bing-shu Li та ін. "Therapeutic Effects of Punicalagin Against Ovarian Carcinoma Cells in Association With β-Catenin Signaling Inhibition". International Journal of Gynecologic Cancer 26, № 9 (2016): 1557–63. http://dx.doi.org/10.1097/igc.0000000000000805.

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AimThe aim of this study was to investigate the effects of punicalagin, a polyphenol isolated from Punica granatum, on human A2780 ovarian cancer cells in vitro.MethodsThe viability of human A2780 ovarian cells was evaluated using Cell Counting Kit-8 assay. Cell cycle was detected with flow cytometry analysis. The protein expression levels of Bcl-2, Bax, β-catenin, cyclin D1, survivin, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-3 were measured using Western blot analysis. Matrix metalloproteinase (MMP)-2 and MMP-9 activity was determined with gelatin zymography. Wound healing ass

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Fan, Lixia, Ningze Zheng, Fuhua Peng, et al. "Nitric oxide affects cisplatin cytotoxicity oppositely in A2780 and A2780‐CDDP cells via the connexin32/gap junction." Cancer Science 111, no. 8 (2020): 2779–88. http://dx.doi.org/10.1111/cas.14436.

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24

Uruski, Paweł, Justyna Mikuła-Pietrasik, Martyna Pakuła, et al. "Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts." International Journal of Molecular Sciences 22, no. 8 (2021): 4222. http://dx.doi.org/10.3390/ijms22084222.

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Although malignant ascites (MAs) are known to contribute to various aspects of ovarian cancer progression, knowledge regarding their role in the adhesion of cancer cells to normal peritoneal cells is incomplete. Here, we compared the effect of MAs and benign ascites (BAs) on the adhesion of A2780 and OVCAR-3 cancer cells to omentum-derived peritoneal mesothelial cells (PMCs) and peritoneal fibroblasts (PFBs). The results showed that MAs stimulated the adhesion of A2780 and OVCAR-3 cells to PMCs and PFBs more efficiently than did BAs, and the strongest binding occurred when both cancer and norm

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Chen, Huiqin, Georgios Daletos, Festus Okoye, Daowan Lai, Haofu Dai, and Peter Proksch. "A New Cytotoxic Cytochalasin from the Endophytic Fungus Trichoderma harzianum." Natural Product Communications 10, no. 4 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000412.

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The new natural product 4′-hydroxy-deacetyl-18-deoxycytochalasin H (1), together with the known deacetyl-18-deoxycytochalasin H (2) and 18-deoxycytochalasin H (3) were obtained from the endophytic fungus Trichoderma harzianum isolated from leaves of Cola nitida. The structure of the new compound was unambiguously determined by 1D and 2D NMR spectroscopy, and by HRESIMS measurements, as well as by comparison with the literature. Compounds 1-3 showed potent cytotoxic activity against the murine lymphoma (L5178Y) cell line and against human ovarian cancer (A2780 sens and A2780 CisR) cell lines (I

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Niu, Ting, Wei Liu, Hua Gao, Wentong Meng, and Ting Liu. "Effect of Liposome Encapsulated Vesicular Stomatitis Virus Matrix Protein in Hematological Malignancy." Blood 112, no. 11 (2008): 4634. http://dx.doi.org/10.1182/blood.v112.11.4634.4634.

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Abstract Objective: Vesicular Stomatitis Virus (VSV) has shown antitumor effects in many studies, however as an active virus,it has biosafety problems when being used in human body. Matrix protein (M protein) of VSV also has antitumor effects without the existence of other portions of VSV.Recently liposome is widely used as a gene delivery vector. So the present study was to investigate the effect of liposome as a gene delivery vector in hematological malignant cell lines and to investigate the effect of liposome encapsulated Vesicular Stomatitis Virus Matrix protein in hematological malignanc

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Hashemi-Sheikhshabani, Somayeh, Zeinab Amini-Farsani, Mehdi Shamsara, Zahra Sajadpoor, Mohammad Hossein Sangtarash, and Hossein Teimori. "Effect of valproic acid on cisplatin-resistant ovarian cancer cell lines." Journal of Shahrekord University of Medical Sciences 21, no. 1 (2019): 39–44. http://dx.doi.org/10.34172/jsums.2019.07.

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Background and aims: Platinum resistance has been one of the most important problems in the management of ovarian cancer. The effects of various chemotherapeutic agents are limited in patients with platinum resistance. Therefore, developing new anticancer drugs that can improve the effect of currently used cytostatics is critical. The current study investigated the effects of valproic acid (VPA) alone and in combination with cisplatin on ovarian cancer cells. Methods: In this experimental study, the human ovarian cancer cell lines (A2780-S and A2780-CP) were grown in RPMI-1640 medium in approp

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Solárová, Zuzana, Martin Kello, and Peter Solár. "Apoptotic Effect of Homobrassinin and Thiazino[6,5-b]indol is Associated with Downregulation of Heat Shock Proteins in Human Ovarian Adenocarcinoma Cells." Acta Chimica Slovenica 68, no. 1 (2021): 151–58. http://dx.doi.org/10.17344/acsi.2020.6281.

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Phytoalexins are substances with antimicrobial properties produced by plants after being attacked by microorganisms, especially phytopathogenic fungi and viruses. They are also currently being studied for their antitumor effect. We aimed to study the apoptosis-stimulating effect of homobrassinin and thiazino[6,5-b]indol in human ovarian adenocarcinoma A2780 and A2780cis cells via flow cytometric analysis of annexin V/PI, caspase 3 and 9 activity, cytochrome C release, and smac-diablo accumulation. Using the western blot technique, we also monitored the effect of both indoles on the response of

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He, Zhiping, Xingquan Liu, Fenghua Wu, et al. "Gallic Acid Induces S and G2 Phase Arrest and Apoptosis in Human Ovarian Cancer Cells In Vitro." Applied Sciences 11, no. 9 (2021): 3807. http://dx.doi.org/10.3390/app11093807.

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Ovarian cancer (OC) is among the top gynecologic cancers in the US with a death tally of 13,940 in the past year alone. Gallic acid (GA) is a natural compound with pharmacological benefits. In this research, the role of GA on cell proliferation, cell apoptosis, cell cycle-related protein expression was explored in OC cell lines OVCAR-3 and A2780/CP70. After 24, 48 and 72 h of GA treatment, the IC50 values in OVCAR-3 cells were 22.14 ± 0.45, 20.36 ± 0.18, 15.13 ± 0.53 μM, respectively and in A2780/CP70 cells IC50 values were 33.53 ± 2.64, 27.18 ± 0.22, 22.81 ± 0.56, respectively. Hoechst 33,342

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Facchetti, Giorgio, Michael S. Christodoulou, Lina Barragán Mendoza, Federico Cusinato, Lisa Dalla Via, and Isabella Rimoldi. "Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds." Molecules 25, no. 23 (2020): 5561. http://dx.doi.org/10.3390/molecules25235561.

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The synthesis of a small library of 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: human T-lymphocyte cells (CEM), human cervix carcinoma cells (HeLa), human dermal microvascular endothelial cells (HMEC-1), colorectal adenocarcinoma (HT-29), ovarian carcinoma (A2780), and biphasic mesothelioma (MSTO-211H). Compounds 3a, 5a, and 2b, showing significant IC50 values against the whole panel of the selected cells, were

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Vančo, Ján, Zdeněk Trávníček, Jan Hošek, Tomáš Malina, and Zdeněk Dvořák. "Copper(II) Complexes Containing Natural Flavonoid Pomiferin Show Considerable In Vitro Cytotoxicity and Anti-inflammatory Effects." International Journal of Molecular Sciences 22, no. 14 (2021): 7626. http://dx.doi.org/10.3390/ijms22147626.

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A series of new heteroleptic copper(II) complexes of the composition [Cu(L)(bpy)]NO3·2MeOH (1), [Cu(L)(dimebpy)]NO3·2H2O (2), [Cu(L)(phen)]NO3·2MeOH (3), [Cu(L)(bphen)]NO3·MeOH (4), [Cu(L)(dppz)]NO3·MeOH (5) was prepared, where HL = 3-(3,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-6-(3-methylbut-2-ene-1-yl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one, (pomiferin) and bpy = 2,2′-bipyridine, dimebpy = 4,4′-dimethyl-2,2′-bipyridine, phen = 1,10-phenanthroline, bphen = 4,7-diphenyl-1,10-phenanthroline, and dppz = dipyrido[3,2-a:2′,3′-c]phenazine. The complexes were characterized using elemental analysis,

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Jeong, Jee-Yeong, Laurie Feldman, Peter Solar, and Arthur J. Sytkowski. "Biological Significance of Erythropoietin and Erythropoietin Receptor Expression by Human Ovarian Cancer Cells." Blood 110, no. 11 (2007): 2214. http://dx.doi.org/10.1182/blood.v110.11.2214.2214.

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Abstract Erythropoietin (Epo) is the primary regulator of erythroid cell proliferation and differentiation mediated through its specific binding to the Epo receptor (EpoR). Epo also is known to have non-hematopoietic actions, including the promotion of wound healing, tissue protection and others. Accumulating evidence demonstrating both Epo and EpoR expression in many types of human cancers has raised concern about the clinical use of Epo and other erythropoiesis stimulating agents (ESAs) in cancer-related anemia, since the presence of functional EpoR on the tumor cells suggests the potential

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Li, Zhao-dong, Xiao-wen Hu, Yu-tian Wang, and Jing Fang. "Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1." FEBS Letters 583, no. 12 (2009): 1999–2003. http://dx.doi.org/10.1016/j.febslet.2009.05.013.

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Selin, Roman O., Insa Klemt, Viktor Ya Chernii, et al. "Synthesis and spectral characterization of the first fluorescein-tagged iron(ii) clathrochelates, their supramolecular interactions with globular proteins, and cellular uptake." RSC Advances 11, no. 14 (2021): 8163–77. http://dx.doi.org/10.1039/d0ra10502c.

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Deng, Xinyue, Nan Lin, Jiaying Fu та ін. "The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer". Oxidative Medicine and Cellular Longevity 2020 (26 листопада 2020): 1–15. http://dx.doi.org/10.1155/2020/4830418.

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Drug resistance remains a barrier in the clinical treatment of ovarian cancer. Proteasomal and antioxidant activities play important roles in tumor drug resistance, and increasing evidence suggests the existence of an interaction between antioxidant and proteasomal activities. However, the mechanism of the synergistic effects of proteasomal activity and antioxidation on tumor drug resistance is not completely clear. In this study, we compared two ovarian cancer cells, A2780 and SKOV3 cells. Among them, SKOV3 cell is a human clear cell carcinoma cell line that is resistant to platinum. We found

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Modarresi, Masoud, Marziyeh Hajialyani, Narges Moasefi, Farahnaz Ahmadi, and Leila Hosseinzadeh. "Evaluation of the Cytotoxic and Apoptogenic Effects of Glabridin and Its Effect on Cytotoxicity and Apoptosis Induced by Doxorubicin Toward Cancerous Cells." Advanced Pharmaceutical Bulletin 9, no. 3 (2019): 481–89. http://dx.doi.org/10.15171/apb.2019.057.

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Purposes: In the present study, we tried for the first time to examine the anti-proliferative and anti-apoptogenic effect of Glabridin (Glab) toward three groups of cancer cells (SKNMC, H1299, and A2780). Furthermore, the possibility of co-administration of Glab with doxorubicin (DOX) to these cells was also examined to find out whether Glab can potentiate the cytotoxic effect of this chemotherapy agent. Methods: Different cellular assays (MTT, caspase-3 activity, MMP, RT-PCR analysis) were carried out on the cancer cells treated with Glab. Results: Cellular toxicity assay revealed that Glab c

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Han, Xi, Shuai Zhen, Zhongxue Ye, et al. "A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells." Cellular Physiology and Biochemistry 41, no. 3 (2017): 973–86. http://dx.doi.org/10.1159/000460618.

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Background: Many microRNAs (miRs) are dysregulated in cancers, and aberrant miR expression patterns have been suggested to correlate with chemo-resistance of cancer cells. We aim to study the role of miR-30 family members in cisplatin-resistance of ovarian cancer cells. Methods: qRT-PCR was used to compare differential expression levels of miR-30 family members in ovarian cancer cell line A2780 and its cisplatin-resistant derivative CP70. Changes of cisplatin-sensitivity in miR-30a-5p- and miR-30c-5p-overexpressed-CP70 cells and miR-30a-5p- and miR-30c-5p-inhibited-A2780 cells were examined by

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Michalak, Marcin, Michał Stefan Lach, Michał Antoszczak, Adam Huczyński, and Wiktoria Maria Suchorska. "Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives—An In Vitro Study." Molecules 25, no. 3 (2020): 537. http://dx.doi.org/10.3390/molecules25030537.

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Polyether ionophore salinomycin (SAL) and its semi-synthetic derivatives are recognized as very promising anticancer drug candidates due to their activity against various types of cancer cells, including multidrug-resistant populations. Ovarian cancer is the deadliest among gynecologic malignancies, which is connected with the development of chemoresistant forms of the disease in over 70% of patients after initial treatment regimen. Thus, we decided to examine the anticancer properties of SAL and selected SAL derivatives against a series of drug-sensitive (A2780, SK-OV-3) and derived drug-resi

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Vascellari, Sarah, Elisa Valletta, Daniela Perra, et al. "Cisplatin, glutathione and the third wheel: a copper-(1,10-phenanthroline) complex modulates cisplatin–GSH interactions from antagonism to synergism in cancer cells resistant to cisplatin." RSC Advances 9, no. 10 (2019): 5362–76. http://dx.doi.org/10.1039/c8ra09652j.

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Ghini, Veronica, Tommaso Senzacqua, Lara Massai, Tania Gamberi, Luigi Messori, and Paola Turano. "NMR reveals the metabolic changes induced by auranofin in A2780 cancer cells: evidence for glutathione dysregulation." Dalton Transactions 50, no. 18 (2021): 6349–55. http://dx.doi.org/10.1039/d1dt00750e.

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NMR-based metabolomics is used to characterize the metabolic phenotype of auranofin treatment in A2780 ovarian cancer cells. The most distinctive trait is an early and evident increase of intracellular GSH, a key molecule in cell redox metabolism.

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Choroba, Katarzyna, Barbara Machura, Luis R. Raposo, et al. "Platinum(ii) complexes showing high cytotoxicity toward A2780 ovarian carcinoma cells." Dalton Transactions 48, no. 34 (2019): 13081–93. http://dx.doi.org/10.1039/c9dt02894c.

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2,6-Bis(thiazol-2-yl)pyridines functionalized with 9-anthryl (L1), 9-phenanthryl (L2), and 1-pyrenyl (L3) groups were used for the preparation of [Pt(L<sup>n</sup>)Cl]CF<sub>3</sub>SO<sub>3</sub> (1–3) with high cytotoxic activity against ovarian cancer cells.

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Valsecchi, Manuela, Massimo Aureli, Laura Mauri, et al. "Sphingolipidomics of A2780 human ovarian carcinoma cells treated with synthetic retinoids." Journal of Lipid Research 51, no. 7 (2010): 1832–40. http://dx.doi.org/10.1194/jlr.m004010.

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Bensing, Christian, Marija Mojić, Santiago Gómez-Ruiz, et al. "Evaluation of functionalized mesoporous silica SBA-15 as a carrier system for Ph3Sn(CH2)3OH against the A2780 ovarian carcinoma cell line." Dalton Transactions 45, no. 47 (2016): 18984–93. http://dx.doi.org/10.1039/c6dt03519a.

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Lee, Da-Hye, Jun-Hyeok Park, Jihye Choi, Kyung-Ju Lee, Bo-Seong Yun, and Kwang-Hyun Baek. "Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate." International Journal of Molecular Sciences 21, no. 5 (2020): 1755. http://dx.doi.org/10.3390/ijms21051755.

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Premature ovarian failure (POF) is defined as loss of ovarian function in women less than 40 years of age. The causes of POF are diverse and include environmental factors. Di-2-ethylhexyl phthalate (DEHP) is one factor that may cause POF. The ubiquitin-proteasome system maintains intracellular balance by promoting or inhibiting protein degradation. To investigate the differential expressions of deubiquitinating enzyme (DUB) genes in patients with POF, we developed two in vitro POF models by treating A2780 or OVCAR5 with DEHP. Using these models, a multiplex RT-PCR system for DUB genes was appl

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Harper, Benjamin W. J., and Janice R. Aldrich-Wright. "The synthesis, characterisation and cytotoxicity of bisintercalating (2,2′:6′,2′′-terpyridine)platinum(ii) complexes." Dalton Transactions 44, no. 1 (2015): 87–96. http://dx.doi.org/10.1039/c4dt02773f.

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Dinuclear (2,2′:6′,2′′-terpyridine)platinum(ii) complexes were synthesised by tethering either thiol or pyridine based linkers. The cytotoxicity of the complexes was determined against human ovarian carcinoma cells (A2780) and its cisplatin-resistant sub-line A2780cis, as well as L1210 murine leukemia cells.

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El-kott, Attalla Farag, Ali A. Shati, Mohammed Ali Al-kahtani, and Sultan Alqahtani. "Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway." Analytical Cellular Pathology 2019 (July 8, 2019): 1–12. http://dx.doi.org/10.1155/2019/9627810.

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This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF-κB survival pathways. Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. In some cases, cisplatin+AG-treated cells were pre-incubated either with [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, or with LY294002, a PI3K inhibitor. mRNA of ghrelin receptors(GHS-R1a and GHS-R1b)

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Feith, Marek, Tomáš Vičar, Jaromír Gumulec, et al. "Quantitative Phase Dynamics of Cancer Cell Populations Affected by Blue Light." Applied Sciences 10, no. 7 (2020): 2597. http://dx.doi.org/10.3390/app10072597.

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Increased exposition to blue light may induce many changes in cell behavior and significantly affect the critical characteristics of cells. Here we show that multimodal holographic microscopy (MHM) within advanced image analysis is capable of correctly distinguishing between changes in cell motility, cell dry mass, cell density, and cell death induced by blue light. We focused on the effect of blue light with a wavelength of 485 nm on morphological and dynamical parameters of four cell lines, malignant PC-3, A2780, G361 cell lines, and the benign PNT1A cell line. We used MHM with blue light do

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Giannini, Federico, Marco Bartoloni, Lydia E. H. Paul, Georg Süss-Fink, Jean-Louis Reymond, and Julien Furrer. "Cytotoxic peptide conjugates of dinuclear arene ruthenium trithiolato complexes." MedChemComm 6, no. 2 (2015): 347–50. http://dx.doi.org/10.1039/c4md00433g.

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Novel dinuclear arene ruthenium trithiolato complexes containing a water-soluble peptide moiety in one of the three thiolato bridges were designed and evaluated against A2780 human ovarian cancer cells and against their cisplatin-resistant mutant A2780cisR.

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Wang, Haiwei, Yuxing Zhang, and Yanzhi Du. "Ovarian and Breast Cancer Spheres Are Similar in Transcriptomic Features and Sensitive to Fenretinide." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/510905.

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Cancer stem cells (CSCs) are resistant to chemotherapy and are ability to regenerate cancer cell populations, thus attracting much attention in cancer research. In this report, we first demonstrated that sphere cells from ovarian cancer cell line A2780 shared many features of CSCs, such as resistance to cisplatin and able to initiate tumors in an efficient manner. Then, we conducted cDNA microarray analysis on spheres from ovarian A2780 cells, and from breast MCF7 and SUM159 cells, and found that molecular pathways underlying spheres from these cancer cell lines were similar to a large extent,

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Ghods, Azadeh, Jayne Gilbert, Jennifer R. Baker, Cecilia C. Russell, Jennette A. Sakoff, and Adam McCluskey. "A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone." Royal Society Open Science 5, no. 4 (2018): 171189. http://dx.doi.org/10.1098/rsos.171189.

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Bolinaquinone is a natural product that is a structurally complex, cytotoxic sesquiterpene quinone. A scaffold simplification and focused library approach using a microwave-assisted Suzuki coupling gave 32 bolinaquinone analogues with good-to-excellent cytotoxicity profiles. Mono-arylbenzoquinones, Library A , were preferentially toxic towards BE2-C (neuroblastoma) cells with growth inhibition (GI 50 ) values of 4–12 µM; only the 3,4-dimethoxyphenyl 23 and 3-biphenyl 28 variants were broad-spectrum active—HT29 (colon carcinoma), U87 and SJ-G2 (glioblastoma), MCF-7 (breast carcinoma), A2780 (ov

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