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Dissertations / Theses on the topic 'A2a'

Author: Grafiati
Published: 4 June 2021
Last updated: 27 April 2022

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1

Larner, Carrie Jayne Byrom. "Selective targeting of the adenosine A2A receptor." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608592.

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2

Bolteau, Raphaël. "Conception, synthèse et évaluation pharmacologique d’antagonistes des récepteurs A2A et de ligands duaux ciblant les récepteurs A2A et mGlu5." Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S006.

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Ces cinquante dernières années ont été marquées par la percée des maladies neurodégénératives comme la maladie d’Alzheimer. À ce jour, il existe uniquement des traitements symptomatiques. De plus, face à cette maladie multifactorielle, il apparaît donc nécessaire d’identifier et d’étudier de nouvelles cibles thérapeutiques. Parmi elles, le récepteur à l’adénosine A2A (A2AR) a fait l’objet de nombreuses études ces dernières années. En effet, ses antagonistes tels que la caféine ont montré de nombreux effets bénéfiques en permettant d’améliorer les performances cognitives par une diminution des
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3

Woollard, Astrid Alexandra Diana. "RAB-A2a dependent membrane traffic in Arabidopsis thaliana." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:448ed7f3-ee8e-4d1c-9784-ad4bed383fc6.

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Rab GTPases are major regulatory proteins of vesicle traffic and thus responsible for membrane identity, vesicle targeting and vesicle fusion. The angiosperm Rab GTPase family is grouped into eight clades (Rab-A to Rab-H) that are broadly conserved in animals and yeasts. It has been proposed that the Rab-A clade has diversified in land plants giving rise to six plant- specific structural subclasses, Rab-A1 to Rab-A6. Previous work suggests that the Arabidopsis Rab-A2 and Rab-A3 proteins define a novel endosomal compartment that lies on a pathway between the Golgi and the plasma membrane. In di
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4

Duroux, Romain. "Conception, synthèse et évaluation d'antagonistes des récepteurs A2A." Thesis, Lille 2, 2017. http://www.theses.fr/2017LIL2S015/document.

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La maladie d’Alzheimer (MA) est la maladie neurodégénérative touchant le plus de personnes dans le monde. Jusqu’à présent, aucun traitement curatif n’existe pour soigner cette maladie, d’où la nécessité d’identifier et d’étudier de nouvelles cibles thérapeutiques.La découverte des effets bénéfiques de la caféine, antagoniste du récepteur à adénosine A2A (A2AR), conjuguée à une surexpression de ce dernier chez les patients atteints de la MA, font de ce récepteur une cible d’intérêt. En effet, des antagonistes des A2ARs ont montré leur capacité à améliorer les performances cognitives de par une
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5

Matsumoto, João Paulo de Pontes. "Efeito modulatório da nicotina sobre o receptor de adenosina A2a em cultura de células do bulbo de ratos geneticamente hipertensos e normotensos." Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-19022009-104148/.

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A hipertensão arterial é um problema de saúde pública no Brasil, pois aproximadamente 20 % da população adulta desenvolve hipertensão essencial, cujas causas ainda não são conhecidas. No entanto, sua gênese pode estar relacionada com disfunção nas áreas do sistema nervoso central (SNC) que regulam o sistema cardiovascular. O núcleo do trato solitário (NTS) e o bulbo ventrolateral são áreas importantes no controle neural da pressão arterial. Os receptores de adenosina A2a (rA2a) são encontrados em todo o SNC e estão relacionados com estudos terapêuticos de diversas doenças. No NTS a estimulação
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6

Gandía, Sánchez Jorge. "Oligomerización del receptor A2A de adenosina: interpretando el receptorsoma." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/134352.

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Los receptores acoplados a proteína G (GPCR) conforman la familia de receptores de membrana más grande. El numeroso y variado tipo de señales que detectan han otorgado a estos receptores un alto interés farmacológico. Además, las interacciones entre diferentes tipos de GPCR formando complejos oligoméricos dan lugar a complejos con características bioquímicas diferenciadas de los protómeros que los forman. En esta Tesis Doctoral se han estudiado diferentes aspectos derivados este tipo de interacciones, centrando estos experimentos alrededor del receptor A2A de adenosina (A2AR), un importante ne
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7

Carvalho, Kévin. "Rôle des récepteurs adénosinergiques A2A dans la maladie d'Alzheimer." Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S030.

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L'accumulation neuronale de protéines tau hyperphosphorylées et agrégées (« pathologie tau ») est corrélée au déclin cognitif dans la maladie d'Alzheimer. Les mécanismes liant tau à la perte de mémoire demeurent néanmoins mal connus. Différentes données épidémiologiques et expérimentales suggèrent que la consommation régulière de caféine réduit le risque de développer la maladie d'Alzheimer ainsi que les lésions et déficits cognitifs associés. Les effets protecteurs de la caféine ont été attribués au blocage des récepteurs à l'adénosine A2A (A2ARs), qui sont retrouvés augmentés dans le cerveau
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8

Bawa, Zharain. "Improving recombinant human adenosine A2A receptor production in yeast." Thesis, Aston University, 2014. http://publications.aston.ac.uk/23176/.

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Over 50% of clinically-marketed drugs target membrane proteins; in particular G protein-coupled receptors (GPCRs). GPCRs are vital to living cells, performing an active role in many processes, making them integral to drug development. In nature, GPCRs are not sufficiently abundant for research and their structural integrity is often lost during extraction from cell membranes. The objectives of this thesis were to increase recombinant yield of the GPCR, human adenosine A2A receptor (hA2AR) by investigating bioprocess conditions in large-scale Pichia pastoris and small-scale Saccharomyces cerevi
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9

Johansson, Fredrik. "Genetisk variation av betydelse för adenosinsignalering vid nydebuterad reumatoid artrit." Thesis, Linköping University, Linköping University, The Department of Physics, Chemistry and Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-16375.

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<p><!-- @page { margin: 2cm } P { margin-bottom: 0.21cm; background: transparent; page-break-before: auto } P.western { font-size: 14pt } --></p><p>Rheumatoid arthritis is an autoimmune disease, where joints are attacked by the own immune system, leading to chronic inflammation and destruction of bone and cartilage. Inflammation is a complex process, controlled by many different substances. One of them is adenosine, which has anti-inflammatory properties. In this project, three polymorphisms in different genes, involved in synthesis and signaling of adenosine, were genotyped for 188 pat
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10

Halldner, Henriksson Linda. "Physiology and pathophysiology of central adenosine A1 and A2A receptors /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-628-5732-0/.

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11

Wells, Lisa Anne. "The role of the adenosine A2A receptor in addictive processes." Thesis, University of Surrey, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492974.

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To investigate adenosine-opioid-dopamine interactions in addictive processes, in vivo microdialysis and quantitative autoradiography were carried out using mice deficient in the adenosine A2A receptor (A2aR-/-).
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12

Stockenhuber, Alexander. "The role of adenosine A2A receptor signalling in cardiac fibrosis." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:cfacf0d7-33c2-455f-97fe-4d5d6255a0a2.

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Myocardial fibrosis contributes to the pathogenesis of diverse forms of cardiac hypertrophy. Recent evidence suggests a crucial role for purinergic signalling in the formation of tissue fibrosis. In particular, inhibition of adenosine A2A receptors (A2AR) in animal models for hepatic and skin fibrosis resulted in a reduction of fibrosis formation. The specific hypothesis of this investigation was that myocardial stress results in increased interstitial levels of adenosine, which activate cardiac fibroblasts via adenosine A2AR. Accordingly, the specific objective of this investigation was to de
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13

Moscoso, Castro Maria 1988. "Study of the involvement of adenosine A2A receptors in the pathophysiology of schizophrenia." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/565401.

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The adenosinergic system is a neuromodulatory complex acting on four receptor subtypes with varying distributions throughout the central nervous system. This system contributes to homeostasis and regulates several physiological functions including sleep, motor function, synaptic plasticity or cognition. Adenosine can exert an upstream modulation of several neurotransmitter systems, including dopamine and glutamate, both implicated in the pathophysiology of neuropsychiatric diseases and particularly in psychosis. Schizophrenia is considered a psychotic disease characterized by a chronic and deb
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14

Costa, Maísa Aparecida. "Efeito modulatório dos receptores A1 e A2A sobre a neurotransmissão nitrérgica em culturas de células da região dorsomedial do bulbo de ratos normotensos e geneticamente hipertensos." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-16042014-152527/.

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Adenosina e óxido nítrico, importantes neuromoduladores endógenos, atuam modulando finamente o controle neural cardiovascular no núcleo de trato solitário (NTS). Embora se tenha conhecimento sobre a relação entre adenosina e NO periférica e centralmente, em particular, no bulbo, os mecanismos pelos quais a adenosina interfere na dinâmica da neurotransmissão nitrérgica, ainda não são totalmente conhecidos. Logo, alterações na interação entre esses sistemas podem ser especialmente relevantes para indivíduos predispostos à hipertensão. Dessa forma, os objetivos do presente estudo foram estudar a
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15

Hedley, Diana. "Investigating agonist induced receptor conformational changes on the adenosine A2a receptor." Thesis, University of Reading, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.553235.

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G-protein coupled receptors (GPCRs) are one of the main targets for drug design. GPCR pharmaceutical research has bottlenecked on drug research, and the current assay systems are not creating therapeutic drugs from drug hits. The principal aim of this project was to establish a relationship between drug affinity (PKi) and drug intrinsic efficacy (Emax) using receptor conformational change parameters (measurements defined by fluorescence resonance energy transfer (FRET) experiments) to provide a new way of screening for the intrinsic efficacy of a drug. This project aimed to develop a drug scre
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16

Al-Hasani, Ream. "The involvement of adenosine A2a receptors in morphine and cocaine addiction." Thesis, University of Surrey, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.510572.

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17

Moas, Heloire Valeria. "Conception, synthèse et évaluation de nouveaux ligands antagonistes de récepteurs A2a." Thesis, Lille 2, 2015. http://www.theses.fr/2015LIL2S007/document.

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L’adénosine est un neuromodulateur ubiquitaire impliqué dans différents processus physiologiques et neuroprotecteurs du système nerveux central. Elle agit via quatre sous-types de récepteurs couplés à protéine G (A1, A2a, A2b et A3). Le récepteur A2a (A2aR) est fortement exprimé dans des régions riches en dopamine, avec de fortes concentrations dans la zone du caudate-putamen du cerveau, où elle a un rôle important dans la transmission neuronale et dans le processus dégénératif d’origine extrapyramidale. Ainsi, le blocage du récepteur A2a s’est révélé être une cible prometteuse pour le traitem
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18

Marlinge, Marion. "Profil du récepteur de l’adénosine A2A dans les pathologies cardio-vasculaires." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0670.

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L’athérosclérose est responsable de la diminution du diamètre des vaisseaux par formation d’une « plaque » constituée notamment de lipides limitant la circulation sanguine (ischémie) et l’oxygénation des tissus. L’adénosine est capable de réguler la fonction cardiovasculaire notamment par le biais de son récepteur A2A qui induit une vasodilatation permettant d’augmenter les apports sanguins. Une faible présence des A2AR semble marquer l’ischémie (sans spécificité de territoire) tandis que la présence de récepteurs de réserve (réponse biologique maximale malgré un faible nombre de sites occupés
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19

Akkuzu, Selin. "The Functional Assessment Of Fluorecently Tagged Adenosine A2a And Dopamine D2 Receptors And Qualitative Analysis Of Dimerization Of Adenosine A2a And Dopamine D2 Receptor By Using Fret." Master's thesis, METU, 2013. http://etd.lib.metu.edu.tr/upload/12615474/index.pdf.

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Recently, several studies have demonstrated that G protein coupled receptors exist as homo/heterodimers or oligomers. Adenosine A2A receptors and dopamine D2 receptors are present as both homo- and heterodimer. In the GABAergic striatopallidal neurons A2AR are co- localized with D2 receptors (D2R), and establish functional A2AR-D2R heteromers, which modulates dopaminergic activity. Due to be involved in physiological processes, these receptors bear critical roles. Dopamine receptors play critical role in dopaminergic pathways in regulation of memory, food intake and psychomotor activity, etc.
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20

Rodríguez, Gretel Rodríguez. "A sinalização via receptor A2A contribui para suscetibilidade ao carcinoma mamário experimental." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-27072016-154619/.

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O câncer de mama é um dos tumores malignos mais comuns e que afeta um grande número de mulheres da população mundial. O processo inflamatório gerado juntamente com o crescimento descontrolado das células tumorais promove um estresse metabólico no microambiente tumoral levando ao acúmulo de adenosina extracelular decorrente da hipóxia tecidual. A adenosina gerada e seus efeitos mediados via receptor A2A (A2AR) interfere em vários subtipos celulares. Neste trabalho, avaliamos o papel do receptor A2A na indução de uma resposta de células Th17 durante o carcinoma mamário experimental, visto que es
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21

Niebauer, Ronald Thomas. "Engineering yeast cells for optimal expression of the human adenosine (A2a) receptor." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file 4.52 Mb., 175 p, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3181857.

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22

Wright, Sherie Rose. "The role of A2A receptors in drug addiction: interaction with mGIu5 receptors." Thesis, University of Surrey, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.583347.

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The mechanism by which the adenosine A2A receptor mediates the actions of multiple drugs of abuse is thought to be partly attributable to interactions with dopamine D2 receptors in the striatum; a key structure in drug-related reward, reinforcement and motor responses. Evidence now suggests that this interaction could be further influenced by actions of the metabotropic glutamate receptor, mGlu5, which is co- expressed with striatal A2A and D2 receptors. This work aimed to identify the role of A2A receptors in mediating the locomotor and stereotypic responses to chronic administration of cocai
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23

Bertheleme, Nicolas. "Functional characterisation of A2A receptor thermostable mutants using a yeast signalling assay." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24701.

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G-protein-coupled receptors (GPCR) are transmembrane proteins that play a crucial role in the communication of cells with their external environment. In the last few years, several GPCR crystal structures have been solved using genetically engineered protein. The turkey β1-adrenergic receptor, the human neutrotensin 1 receptor and the adenosine A2A receptor (A2AR) structures involved the introduction of stabilizing mutations. The engineered mutant can be stabilized in an agonist or an antagonist bound conformation making the GPCR less flexible and therefore easier to crystallize. The aim of th
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24

Robinson, Sarel Johannes. "Syntheses of chalcones and 2-aminopyrimidines and their evaluation as monoamine oxidase inhibitors and as adenosine receptor antagonists / Sarel Johannes Robinson." Thesis, North-West University, 2013. http://hdl.handle.net/10394/9534.

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Background and rationale - Parkinson’s disease is a neurodegenerative disorder characterised by reduced levels of dopamine in the brain. The cause of Parkinson's disease is still unknown; however several theories pertaining to the etiology exist. Current treatment mainly aims at dopamine replacement, with agents such as levodopa and dopamine agonists that provide patients with symptomatic relief. This relief is unfortunately only temporary as the progression of the disease is not halted. Furthermore, these therapies are associated with a range of side effects and novel approaches to the treat
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25

Hoelzl, Alwin. "Modulation von polymorphkernigen Leukozyten durch das Adenosin A2A-Rezeptorsystem bei Patienten mit Sepsis." Diss., lmu, 2007. http://nbn-resolving.de/urn:nbn:de:bvb:19-64447.

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26

Deharo, Pierre. "Implication de l’homocystéine, de l’adénosine et de ses récepteurs A2A dans la coronaropathie." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0473.

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L'adénosine est un dérivé de l’ATP, dont le métabolisme est étroitement lié à celui de l’homocystéine (HCy) via le cycle de la methionine. L’adénosine augmente en concentration au cours de processus ischémiques ou inflammatoires. Dans un premier travail nous avons observé des concentrations élevées d’adénosine, d’HCy et d’acide urique chez le coronarien par rapport aux sujets sains, ainsi qu’une corrélation entre concentration en adénosine plasmatique (APL) et HCy d’une part et entre APL et concentration en HCy d’autre part. Notre étude in vitro montre que l’ajout d’adénosine dans le milieu de
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27

Breidenbach, Marc. "Trägerarm markierte 6-Aminopurinderivate als potentielle Adenosin-A2A-Rezeptorliganden für die Positronen-Emissions-Tomographie." [S.l.] : [s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=970157649.

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28

Thevenin, Damien. "Roles of transmembrane domains in the folding and assembly of the adenosine A2A receptor." Access to citation, abstract and download form provided by ProQuest Information and Learning Company; downloadable PDF file, 170 p, 2007. http://proquest.umi.com/pqdweb?did=1260822171&sid=2&Fmt=2&clientId=8331&RQT=309&VName=PQD.

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29

Aguiar, Lissiana Magna Vasconcelos. "Antagonismo do receptor da adenosina A2a: Nova perspectiva para o tratamento da doenÃa de Parkinson." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=3047.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>A doenÃa de Parkinson (DP) à uma desordem neurodegenerativa, caracterizada pela destruiÃÃo dos neurÃnios nigroestriatais dopaminÃrgicos. O tratamento atual para esta doenÃa està restrito ao alÃvio sintomÃtico, porque atà o presente momento nÃo existem agentes capazes de inibir a degeneraÃÃo neuronal. Existem evidÃncias experimentais de que antagonistas de receptores A2A da adenosina poderiam ser Ãteis no tratamento de DP. Com a finalidade de investigar essa possibilidade, o presente trabalho demonstrou os efeitos da cafeÃna e do
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30

Matsumoto, João Paulo de Pontes. "Receptor A2a de adenosina: estudo da modulação da liberação de neurotransmissores em modelo in vitro." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-03042013-115748/.

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A transmissão sináptica é essencial para o funcionamento do sistema nervoso. A neuromodulação permite regular esse processo de forma precisa. Um desses mecanismos modulatórios é a regulação da liberação de neurotransmissores. A adenosina é um importante modulador da transmissão sináptica. Além disso, a ativação do subtipo A2a dos receptores para adenosina está envolvida com a facilitação da liberação de neurotransmissores no sistema nervoso central. O presente trabalho teve como objetivo avaliar os efeitos modulatórios da ativação do receptor A2a de adenosina sobre a liberação de neurotransm
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31

Carriba, Domínguez Paulina. "Heteromerización de receptores de adenosina A2A, dopamina D2 y cannabinoides CB1. Implicaciones farmacológicas y funcionales." Doctoral thesis, Universitat de Barcelona, 2007. http://hdl.handle.net/10803/1019.

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La visión de los receptores acoplados a proteína G ha evolucionado en los últimos años. Clásicamente se consideraban unidades individuales capaces de producir una señal intracelular; actualmente, está aceptado que estas proteínas de membrana pueden interaccionar con otros receptores de siete dominios transmembrana y que estas interacciones pueden dar lugar a nuevas propiedades farmacológicas de los receptores involucrados.<br/>En el sistema nervioso central este escenario es muy atractivo porque las interacciones receptor-receptor pueden estar implicadas en la neurotransmisión y la neuromodula
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Morató, Arús Xavier. "GPR37-ADENOSINE A2A receptor-receptor interaction as a new pharmacological target for Parkinson’s disease treatment." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/457874.

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GPR37 is an orphan GPCR that belongs to the Rodhopsin family. GPR37 is highly expressed in the Central Nervous System (CNS), while little peripheral expression has been found in humans and rodents. GPR37 is highly distributed in the brain, particularly at the cerebellum, corpus callosum, substantia nigra, striatum and hippocampus with a predominantly neuronal distribution. However, the function of this receptor in the CNS remains unknown. The interest on GPR37 biology was bolstered when it was described as a Parkin substrate. GPR37 was isolated from a human brain library in a yeast 2-hybrid sc
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Milne, Gillian R. "The A2A adenosine receptor : its role in suppressing vascular inflammation and its regulation by phosphorylation." Thesis, University of Glasgow, 2009. http://theses.gla.ac.uk/537/.

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Endothelial inflammation leading to vascular dysfunction is a major contributor to the development of atherosclerosis. The release of adenosine at sites of inflammation represents an endogenous mechanism for limiting excessive inflammation and tissue damage. The majority of the anti-inflammatory effects of adenosine are mediated by signalling through the A2AAR and activation of the A2AAR has been shown to be protective in numerous models of inflammatory disease. Little is known about the molecular mechanisms behind these effects. However, in vitro studies using cultured endothelial cells indic
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Pagnussat, Natália. "O envolvimento dos receptores de adenosina A1 e A2A na memória em camundongos machos adultos." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/131897.

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A cafeína é o psicoestimulante mais consumido mundialmente. Sua ação farmacológica consiste em bloquear os receptores de adenosina A1 e A2A. A administração crônica de cafeína previne déficits cognitivos decorrentes da idade e em modelos experimentais da doença de Alzheimer. Esses efeitos preventivos são também observados pela administração do antagonista seletivo do receptor de adenosina A2A. Nesse trabalho investigou-se a participação dos receptores de adenosina A1 e A2A na prevenção dos déficits cognitivos induzidos por escopolamina. Também foi investigado se a manipulação dos receptores A2
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Aguiar, Lissiana Magna Vasconcelos. "Antagonismo do receptor da adenosina A2a : nova perspectiva para o tratamento da doença de Parkinson." reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/2744.

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AGUIAR, Lissiana Magna Vasconcelos. Antagonismo do receptor da adenosina A2a : nova perspectiva para o tratamento da doença de Parkinson. 2009. 215 f. Tese (Doutorado em Farmacologia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2009.<br>Submitted by denise santos (denise.santos@ufc.br) on 2012-06-14T12:05:44Z No. of bitstreams: 1 2009_tese_lmvaguiar.pdf: 4247715 bytes, checksum: 824a44fc5b2266d47deaa9a03cb884de (MD5)<br>Approved for entry into archive by Eliene Nascimento(elienegvn@hotmail.com) on 2012-06-14T12:52:54Z (GMT) No. of bitstreams: 1 2009_tese_lmvaguiar.pdf: 4
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Świrski, Mateusz. "Synteza innowacyjnych małocząsteczkowych modulatorów immunosupresyjnego szlaku adenozyny." Praca doktorska, 2022. https://ruj.uj.edu.pl/xmlui/handle/item/289708.

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Svobodová, Magdaléna. "Mikroglie kontrolují astrogliózu zprostředkovanou adenosinovými A2A-receptory." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-370979.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Magdaléna Svobodová Supervisor: Assoc. Prof. Přemysl Mladěnka, Ph.D. Assoc. Prof. Maria da Glória Correia da Silva Queiroz, Ph.D. Title of diploma thesis: Microglia control adenosine A2A-receptor mediated astrogliosis In the central nervous system, astrocytes and microglia are the main cells coordinating the inflammatory response. During inflammation, dying or temporarily damaged cells release ATP, as a danger-associated signal molecule, that contributes to the induction of astrogliosi
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Chien, Chen-li, and 簡禎利. "Characterization of the Rat A2A Adenosine Receptor Gene." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/86892298259924920964.

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碩士<br>國立陽明大學<br>神經科學研究所<br>89<br>The rat A2A adenosine receptor (A2A-R) is heavily enriched in the striatum and is also expressed at relatively low levels in other areas of the brain. Gene of A2A-R contains two independent promoters (P1 and P2). Transcripts produced from these two promoters differ in the length of their 5'-untranslated regions (5'-UTR), but encode the same protein. To further characterize the transcriptional regulation of the A2A-R gene in vivo, a fusion gene consisting the 4.8 kb 5'-flanking region / full length 5'UTR of the A2A-R gene and the coding region of the N-lacZ (n-β
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"Cholesterol Dependent Signaling of the Adenosine A2a Receptor." Tulane University, 2018.

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acase@tulane.edu<br>G-protein coupled receptors (GPCRs) represent the largest family of receptor proteins in the living world, having approximately 800 human genes predicted. GPCRs are therapeutically relevant, as approximately 35% of all drugs on the market target them. However, these drugs can be associated with unwanted side effects, due to ubiquitous GPCR expression throughout the body, as well as GPCRs within the same family having common ligands, but varying or contradictory responses. Although there are approximately 800 human GPCRs predicted, the high-resolution crystal structure of on
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Reis, Sara Cristina Lourenço dos. "CONTROL OF FEAR MEMORY BY ADENOSINE RECEPTORS: role in the physiology of the related brain circuitry and implications for fear extinction and post-traumatic stress disorder." Master's thesis, 2017. http://hdl.handle.net/10316/82884.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Anxiety- and trauma-related disorders such as post-traumatic stress disorder (PTSD) are characterized by pathological fear responses and impaired extinction of aversive memories. In both humans and rodents, caffeine intake in moderate doses correlates negatively with anxiety behavior, depression and cognitive dysfunction. These effects of caffeine are now known to be mediated mainly through the antagonism of adenosine A2A receptors (A2AR) in regions of the forebrain. In addition, A2AR in
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Domingues, Marlene Santos. "Impact of astrocytes in memory: role of astrocytic adenosine A2A receptors." Master's thesis, 2019. http://hdl.handle.net/10316/87836.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>Os astrócitos são células gliais com um papel chave no cérebro, exercendo várias funções essenciais. Além de funções de suporte, os astrócitos são capazes de comunicar com os neurónios, constituindo o terceiro elemento ativo da sinapse (sinapse tripartida). Assim, os astrócitos têm um papel importante na regulação da função sináptica e memória, modulando a plasticidade sináptica através da captação de glutamato e GABA e da libertação de gliotransmissores como glutamato, ATP e D-serina. O
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Cagnina, Rebecca Elaine. "Cellular targets and immune modulatory function of adenosine A₂[A] and A₂[B] receptors in murine lung /." 2008. http://wwwlib.umi.com/dissertations/fullcit/3322525.

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Thesis (Ph. D.)--University of Virginia, 2008.<br>In title: [A] is subscript upper case A; [B] is subscript upper case B. Includes bibliographical references. Also available online through Digital Dissertations.
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Tseng, Hua-an, and 曾華安. "Functions of the C-terminus of A2A adenosine receptor." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/28772286222296603126.

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碩士<br>國立陽明大學<br>神經科學研究所<br>91<br>Abstract The A2A Adenosine receptor (A2A-R) is a G-protein coupled receptor (GPCR) with molecular weight of 45kDa. Stimulation of A2A-R can activate adenylyl cyclase via Gs, and subsequently leads to an elevation of the cellular cyclic AMP (cAMP) content. Among the members of adenosine receptor family, A2A-R carries the longest C-terminus with functions largely uncharacterized. Using the yeast-two hybrid system, our laboratory previously found that A2A-R directly interacted with a novel protein, Translin-associated factor X (TraX) by its C-terminus
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Woodard, Robin Leigh. "Purification and characterization of the human A2A adenosine receptor /." 1997. http://wwwlib.umi.com/dissertations/fullcit/9708643.

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Liu, Chao-Ning, and 劉兆寧. "A2A: Attention to Attention Reasoning for Movie Question Answering." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/vwu6sd.

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碩士<br>國立清華大學<br>資訊工程學系所<br>106<br>This thesis presents the Attention to Attention (A2A) reasoning mecha-nism to address the challenging task of movie question answering (MQA). By focusing on the various aspects of attention cues, we establish the tech-nique of attention propagation to uncover latent but useful information to solving the underlying QA task. In addition, the proposed A2A reasoning seamlessly leads to effective fusion of different representation modalities about the data, and also can be conveniently constructed with popular neural network architectures. To tackle the out-of-voca
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Rodrigues, Joana Grácio. "Hematopoiesis in transgenic rats overexpressing neuronal adenosine A2A receptors." Master's thesis, 2015. http://hdl.handle.net/10451/22640.

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Tese de mestrado em Biologia Humana e Ambiente, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2015<br>A hematopoiese é um processo contínuo pelo qual são geradas as células do sangue, a partir das células estaminais hematopoiéticas. Nos adultos, ocorre na medula óssea e a sua regulação envolve vários factores e múltiplas vias de sinalização. Duas grandes linhagens derivam das células estaminais hematopoiéticas: a linhagem mielóide, onde se inserem os monócitos/macrófagos, plaquetas, glóbulos vermelhos e granulócitos (eosinófilos, basófilos e neutrófilos), e a linhagem
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Carvalho, Sara Alexandra Fernandes. "Subcellular localization of adenosine A2a receptors in hippocampal synapses." Master's thesis, 2013. http://hdl.handle.net/10451/10272.

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Tese de mestrado em Bioquímica (Bioquímica Médica), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2013<br>A adenosina é um metabolito existente em todas as células e, tem um papel importante na função neuronal. Actualmente crê-se que este metabolito tem não só um papel como neuromodulador, mas também como regulador homeostático. O conceito de neuromodulador está relacionado com a capacidade de uma substância endógena, libertada na fenda sináptica, influenciar a libertação (modulação pré-sináptica) ou a acção (modulação pós-sináptica) do neurotransmissor. A adenosina é
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Sá, Ana Teresa Capitão Moreira de. "Targeting adenosine A2A receptors to manage Angelman syndrome symptoms." Master's thesis, 2019. http://hdl.handle.net/10316/87879.

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Dissertação de Mestrado em Biologia Celular e Molecular apresentada à Faculdade de Ciências e Tecnologia<br>A síndrome de Angelman (SA) é um distúrbio neuro-genético raro caracterizado por atrasos no desenvolvimento cognitivo, défices motores (ataxia e movimentos desconexos), crises epiléticas e um comportamento peculiar, com os pacientes a manifestar um sorriso fácil e frequente. Esta patologia está associada a uma variedade de mecanismos genéticos e epigenéticos que envolvem a região cromossómica 15q11.2-q13, os quais resultam na perda de função da proteína Ube3A nos neurónios – codificada p
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Dias, Rafael Mendes. "Astrocytic cAMP Signaling and Metabolism: Adenosine A2A Receptors Modulation." Master's thesis, 2020. http://hdl.handle.net/10316/93942.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>Astrócitos, células do Sistema Nervoso Central, não geram potenciais de ação, mas, em resposta a estímulos, os seus níveis intracelulares de cAMP e Ca2+ podem oscilar. Os astrócitos são importantes para os processos metabólicos das células cerebrais devido à sua capacidade de acumular glicogénio no citoplasma e glucose no retículo endoplasmático, graças à ação da glucose-6-fosfatase-β (G6Pase-β). O consumo de glucose e glicogénio pelos astrócitos origina lactato, que é transportado para neurónios. Compree
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Henriques, Vanessa Jorge. "Astrocytic A2A receptors : novel targets to manage brain disorders." Master's thesis, 2016. http://hdl.handle.net/10316/41013.

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Dissertação de mestrado em Investigação Biomédica, apresentada à Faculdade de Medicina da Universidade de Coimbra<br>Adenosine is a prototypic modulator of synaptic transmission in the CNS; it mainly controls excitatory transmission through a coordinated action of inhibitory A1 receptors and facilitatory adenosine A2A receptors (A1R, A2AR) and, albeit their physiological and pathological role have mainly been assumed to result from their direct action on neurons, they are also present in astrocytes where they control astrogliosis, proliferation, cell death, and the release of neurotrophic
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