Academic literature on the topic 'A2KS'

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Journal articles on the topic "A2KS"

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Liu, Ning, Yinghua Jiang, Joon Yong Chung, et al. "Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice." International Journal of Molecular Sciences 20, no. 24 (2019): 6125. http://dx.doi.org/10.3390/ijms20246125.

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Our laboratory and others previously showed that Annexin A2 knockout (A2KO) mice had impaired blood–brain barrier (BBB) development and elevated pro-inflammatory response in macrophages, implying that Annexin A2 (AnxA2) might be one of the key endogenous factors for maintaining homeostasis of the neurovascular unit in the brain. Traumatic brain injury (TBI) is an important cause of disability and mortality worldwide, and neurovascular inflammation plays an important role in the TBI pathophysiology. In the present study, we aimed to test the hypothesis that A2KO promotes pro-inflammatory response in the brain and worsens neurobehavioral outcomes after TBI. TBI was conducted by a controlled cortical impact (CCI) device in mice. Our experimental results showed AnxA2 expression was significantly up-regulated in response to TBI at day three post-TBI. We also found more production of pro-inflammatory cytokines in the A2KO mouse brain, while there was a significant increase of inflammatory adhesion molecules mRNA expression in isolated cerebral micro-vessels of A2KO mice compared with wild-type (WT) mice. Consistently, the A2KO mice brains had a significant increase in leukocyte brain infiltration at two days after TBI. Importantly, A2KO mice had significantly worse sensorimotor and cognitive function deficits up to 28 days after TBI and significantly larger brain tissue loss. Therefore, these results suggested that AnxA2 deficiency results in exacerbated early neurovascular pro-inflammation, which leads to a worse long-term neurologic outcome after TBI.
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Tomaszewski, Waldemar, Vladimir Gun’ko, Roman Leboda, and Jadwiga Skubiszewska-Zięba. "Interaction of methoxy- and methylenedioxyamphetamines with carbon and polymeric adsorbents in polar liquids." Open Chemistry 8, no. 4 (2010): 750–57. http://dx.doi.org/10.2478/s11532-010-0042-y.

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AbstractSolid phase extraction (SPE) of methoxy- and methylenedioxyamphetamines from diluted aqueous solutions was investigated on carbon and polymeric adsorbents of different textures and chemical compositions. Those adsorbents were applied cartridges packed with three chemically modified carbons prepared from plum stones (initial A2PS, oxidized A2PS-O, and reduced A2PS-H) and commercially available adsorbents (polymeric LiChrolut EN, graphitized Hypercarb and Carboprep). Several factors influence the recovery rates of amphetamine derivatives such as the polarity of adsorbates (free energy of salvation), the specific surface area and surface composition of adsorbents, and the solvent characteristics. Different combinations of these factors affect the recovery rate (R1) for high- and low-surface area adsorbents. The minimal R1 values are observed for an amphetamine derivative at a maximal solvation effect and for a set of amphetamines adsorbed on graphitized carbons.
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Yates, P. J., R. Hazen, M. St. Clair, L. Boone, M. Tisdale, and R. C. Elston. "In Vitro Development of Resistance to Human Immunodeficiency Virus Protease Inhibitor GW640385." Antimicrobial Agents and Chemotherapy 50, no. 3 (2006): 1092–95. http://dx.doi.org/10.1128/aac.50.3.1092-1095.2006.

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ABSTRACT Development of in vitro resistance to GW640385, a new human immunodeficiency virus type 1 protease inhibitor, was studied. Variants characterized included one with <4-fold resistance and amino acid substitutions Q58E/A71V (protease) and P452K (Gag) and one with >50-fold resistance and amino acid substitutions L10F/G16E/E21K/A28S/M46I/F53L/A71V (protease) and L449F/P453T (Gag). The A28S substitution substantially reduced replication capacity.
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de Almeida, Pedro. "Generating APL printouts with a2ps." ACM SIGAPL APL Quote Quad 35, no. 3 (2007): 18–23. http://dx.doi.org/10.1145/1286361.1286363.

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Knopf, Alison. "Stimulants for preschool ADHD down, A2As up." Alcoholism & Drug Abuse Weekly 32, no. 37 (2020): 4–5. http://dx.doi.org/10.1002/adaw.32841.

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Xie, Jingli, Zhiguo Luo, and Guoping Chen. "Homoclinic Solutions for a Class of the Second-Order Impulsive Hamiltonian Systems." Abstract and Applied Analysis 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/583107.

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This paper is concerned with the existence of homoclinic solutions for a class of the second order impulsive Hamiltonian systems. By employing the Mountain Pass Theorem, we demonstrate that the limit of a2kT-periodic approximation solution is a homoclinic solution of our problem.
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Nigam, Santosh, and Tankred Schewe. "Phospholipase A2s and lipid peroxidation." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1488, no. 1-2 (2000): 167–81. http://dx.doi.org/10.1016/s1388-1981(00)00119-0.

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Paisansathan, Chanannait, Haoliang Xu, Francesco Vetri, Moises Hernandez, and Dale A. Pelligrino. "Interactions between adenosine and K+ channel-related pathways in the coupling of somatosensory activation and pial arteriolar dilation." American Journal of Physiology-Heart and Circulatory Physiology 299, no. 6 (2010): H2009—H2017. http://dx.doi.org/10.1152/ajpheart.00702.2010.

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Multiple, perhaps interactive, mechanisms participate in the linkage between increased neural activity and cerebral vasodilation. In the present study, we assessed whether neural activation-related pial arteriolar dilation (PAD) involved interactions among adenosine (Ado) A2 receptors (A2Rs), large-conductance Ca2+-operated K+ (BKCa) channels, and inward rectifier K+ (Kir) channels. In rats with closed cranial windows, we monitored sciatic nerve stimulation (SNS)-induced PAD in the absence or presence of pharmacological blockade of A2Rs (ZM-241385), ecto-5′-nucleotidase (α,β-methylene-adenosine diphosphate), BKCa channels (paxilline), and Kir channels (BaCl2). Individually, these interventions led to 53–66% reductions in SNS-induced PADs. Combined applications of these blockers led to little or no further repression of SNS-induced PADs, suggesting interactions among A2Rs and K+ channels. In the absence of SNS, BaCl2 blockade of Kir channels produced 52–80% reductions in Ado and NS-1619 (BKCa channel activator)-induced PADs. In contrast, paxilline blockade of BKCa channels was without effect on dilations elicited by KCl (Kir channel activator) and Ado suffusions, indicating that Ado- and NS-1619-associated PADs involved Kir channels. In addition, targeted ablation of the superficial glia limitans was associated with a selective 60–80% loss of NS-1619 responses, suggesting that the BKCa channel participation (and paxilline sensitivity) derived largely from channels within the glia limitans. Additionally, blockade of either PKA or adenylyl cyclase caused markedly attenuated pial arteriolar responses to SNS and, in the absence of SNS, responses to Ado, KCl, and NS-1619. These findings suggested a key, possibly permissive, role for A2R-linked cAMP generation and PKA-induced K+ channel phosphorylation in somatosensory activation-evoked PAD.
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Gonzalez-Buritica, H., M. A. Khamashita, and G. R. Hughes. "Synovial fluid phospholipase A2s and inflammation." Annals of the Rheumatic Diseases 48, no. 4 (1989): 267–69. http://dx.doi.org/10.1136/ard.48.4.267.

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Murakami, Makoto. "Novel functions of phospholipase A2s: Overview." Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864, no. 6 (2019): 763–65. http://dx.doi.org/10.1016/j.bbalip.2019.02.005.

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Dissertations / Theses on the topic "A2KS"

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Rottleb, René. "Das Paradigma des homogenen Enterprise Access Managements sowie ein Vorschlag zur unternehmensweit konsistenten Zugriffssteuerung." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2003. http://nbn-resolving.de/urn:nbn:de:swb:14-1071583567796-84449.

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Bei der Umsetzung moderner Managementkonzepte wie bspw. Supply Chain Management, Customer Relationship Management und Partner Relationship Management werden Anwendungssysteme wertschöpfungskettenübergreifend eingesetzt. Das bedeutet, dass sowohl interne als auch externe Benutzer auf verschiedene Anwendungssysteme eines Unternehmens zugreifen. Die daraus resultierenden Anforderungen werden als Paradigma des homogenen Enterprise Access Managements (hEAM) beschrieben. Zur Umsetzung dieser Anforderungen wird ein Referenzmodell zur anwendungssystemübergreifend konsistenten Zugriffssteuerung (MAKS) entwickelt. Eine entsprechende Realisierungsmöglichkeit in Form eines zentralen Rollen- und Rechtemanagementsystems (ZR2MS) ergibt sich aus der Referenzarchitektur zur anwendungssystemübergreifend konsistenten Zugriffssteuerung (A2KS).
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Rottleb, René. "Das Paradigma des homogenen Enterprise Access Managements sowie ein Vorschlag zur unternehmensweit konsistenten Zugriffssteuerung." Doctoral thesis, Technische Universität Dresden, 2002. https://tud.qucosa.de/id/qucosa%3A24282.

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Bei der Umsetzung moderner Managementkonzepte wie bspw. Supply Chain Management, Customer Relationship Management und Partner Relationship Management werden Anwendungssysteme wertschöpfungskettenübergreifend eingesetzt. Das bedeutet, dass sowohl interne als auch externe Benutzer auf verschiedene Anwendungssysteme eines Unternehmens zugreifen. Die daraus resultierenden Anforderungen werden als Paradigma des homogenen Enterprise Access Managements (hEAM) beschrieben. Zur Umsetzung dieser Anforderungen wird ein Referenzmodell zur anwendungssystemübergreifend konsistenten Zugriffssteuerung (MAKS) entwickelt. Eine entsprechende Realisierungsmöglichkeit in Form eines zentralen Rollen- und Rechtemanagementsystems (ZR2MS) ergibt sich aus der Referenzarchitektur zur anwendungssystemübergreifend konsistenten Zugriffssteuerung (A2KS).
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Jhan, Jyun-Siang, and 詹竣翔. "Novel Non-Steroidal Anti-Inflammatory Drugs Design Based on Quantitative-Structure Activity Relationship for Inhibitions of Naja mossambica mossambica, Bee Venom, and Porcine Pancreatic Phospholipase A2s by 3-Acyloxy-1-N-n-Octylcarbanyl Benzenes." Thesis, 2010. http://ndltd.ncl.edu.tw/handle/28133819181975801434.

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Books on the topic "A2KS"

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Morrison, G. W. Power of the A2s (Power Series). OPC Railprint, 2004.

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Reichen, Jürgen. Lesen durch Schreiben A2K. Hannah hat Kino im Kopf. Heinevetter Lehrmittel, 2004.

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Access to Knowledge in the Age of Intellectual Property. MIT Press, 2010.

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Deere Birkbeck, Carolyn. Intellectual Property, Development, and Access to Knowledge. Edited by Rochelle Dreyfuss and Justine Pila. Oxford University Press, 2018. http://dx.doi.org/10.1093/oxfordhb/9780198758457.013.36.

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This chapter examines debates on intellectual property (IP) and development in the wider context of issues relating to IP and the public interest. It also considers how calls for greater attention to development in the global IP system relate to campaigns for “access to knowledge” (A2K). After reviewing the longstanding debates on IP and public policy issues as well as the substance of debates on IP, development, and A2K, the article discusses the engagement of developing countries in the international IP system up until the end of the World Trade Organization’s Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS) negotiations. It proceeds with a review of post-TRIPS debates on the Agreement itself, before concluding with an analysis of the continuing challenges of addressing public interest and development concerns in the increasingly complex global IP system.
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Book chapters on the topic "A2KS"

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Dennis, Edward A. "Potential Phospholipase A2s Involved in Inflammatory Diseases." In Novel Molecular Approaches to Anti-Inflammatory Therapy. Birkhäuser Basel, 1995. http://dx.doi.org/10.1007/978-3-0348-7276-8_4.

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Murakami, Makoto, and Ichiro Kudo. "Cellular Arachidonate-Releasing Functions of Various Phospholipase A2s." In Advances in Experimental Medicine and Biology. Springer US, 2003. http://dx.doi.org/10.1007/978-1-4419-9194-2_17.

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Lin, Z. J., L. Tang, K. H. Zhao, et al. "Structures and Pharmacological Activities of Phospholipase A2s fromAgkistrodon halysPallas." In ACS Symposium Series. American Chemical Society, 1999. http://dx.doi.org/10.1021/bk-2000-0745.ch017.

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Li-Stiles, Bangyan, Herng-Hsiang Lo, and Susan M. Fischer. "Differential Activation of Keratinocyte Phospholipase A2S by Tumor Promoters and other Irritants." In Advances in Experimental Medicine and Biology. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4899-1813-0_18.

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Murakami, Makoto, Terumi Kambe-Ohkura, and Ichiro Kudo. "Functional coupling between Phospholipase a2s and cyclooxygenases in immediate and delayed prostanoid biosynthetic pathways." In Advances in Experimental Medicine and Biology. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0193-0_3.

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Coronado, M. A., F. R. de Moraes, A. Ullah, et al. "Three-Dimensional Structures and Mechanisms of Snake Venom Serine Proteinases, Metalloproteinases, and Phospholipase A2s." In Venom Genomics and Proteomics. Springer Netherlands, 2016. http://dx.doi.org/10.1007/978-94-007-6416-3_17.

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Shimbara, Satoko, Makoto Murakami, Terumi Kambe, and Ichiro Kudo. "Comparison Of Recombinant Types IIA, V And IIC Phospholipase A2S, the Three Related Mammalian Secretory Phospholipase A2 Isozymes." In Advances in Experimental Medicine and Biology. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4793-8_31.

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Steiner, Marion R., John S. Bomalaski, and Mike A. Clark. "The Purification of Two Intracellular Phospholipase A2s and the Effects of Phospholipase A2 Activating Protein and Mellitin on Their Activities." In Prostaglandins, Leukotrienes, Lipoxins, and PAF. Springer US, 1991. http://dx.doi.org/10.1007/978-1-4899-0727-1_18.

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Lattke, H., and C. Schönberger. "α2-HS-Glycoprotein ( A2HS): Improved Phenotyping by Focusing in an Immobilized pH-Gradient. Allele Frequencies in a South German Population Sample and Linkage Data from a Large Pedigree." In Advances in Forensic Haemogenetics. Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73330-7_45.

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"A2HS." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_300041.

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Conference papers on the topic "A2KS"

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Gupta, Aditi, Divyansh Jaiswal, Kartikeya Sinha, and Aman Duggal. "A2KD string pattern Matching Algorithm." In 2015 1st International Conference on Next Generation Computing Technologies (NGCT). IEEE, 2015. http://dx.doi.org/10.1109/ngct.2015.7375141.

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Rajesh, M., and D. Muruganandam. "On proposing automobile accident prevention system (A2PS) using wireless sensors and zigbee technology." In 2012 Third International Conference on Computing, Communication and Networking Technologies (ICCCNT 2012). IEEE, 2012. http://dx.doi.org/10.1109/icccnt.2012.6396066.

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Prameswari, Yunita, FNU Djenal, and FNU Damanhuri. "Respon Pemberian Aspirin dan Kinetin Terhadap Pembentukan Umbi Mikro Kentang (Solanum tuberosum L.) Secara In Vitro." In Seminar, Expo dan Diskusi (SEEDs) Perbenihan Nasional 2017. AGROPROSS, National Conference Proceedings of Agriculture, 2017. http://dx.doi.org/10.25047/agropross.2017.15.

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Kebutuhan kentang yang semakin tinggi menyebabkan permintaan semakin meningkat. Rendahnya produksi kentang mengakibatkan berbagai upaya untuk peningkatan produksi terus dilakukan. Penggunaan metode kultur jaringan yaitu metode untuk mengisolasi bagian tanaman seperti protoplasma, sel, sekelompok sel, jaringan dan organ dalam kondisi aseptik, sehingga dapat diperbanyak dan beregenerasi menjadi tanaman utuh dapat dijadikan alternatif pemenuhan kebutuhan. Penelitian ini bertujuan untuk mengetahui kecepatan pembentukan umbi mikro kentang (Solanum Tuberosum L.) varietas granola kembang secarain vitro dengan menggunakan dua faktor dan 3 kali ulangan. Faktor pertama yaitu aspirin dengan tiga taraf (5,10,15) ppm. Faktor kedua yaitu kinetin dalam tiga taraf (8,10,12) ppm. Penelitian menggunakan seluruh propagul kentang yang berumur 30 hari setelah subkultur dan data yang didapat dianalisis menggunakan ANOVA. Hasil penelitian menunjukan bahwa interaksi aspirin dan kinetin tidak berpengaruh terhadap jumlah akar, kedinian umbi, dan bobot umbi. Interaksi perlakuan terbaik bagi pembentukan tunas yaitu A2K1 aspirin 10 ppm dan kinetin 8 ppm sedangkan Interaksi perlakuan terbaik pada parameter jumlah umbi yaituA3K2 aspirin 15 ppm dan kinetin 10.
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Reports on the topic "A2KS"

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Suthersanen, Uma. A2K and the WIPO Development Agenda. International Centre for Trade and Sustainable Development, 2008. http://dx.doi.org/10.7215/ip_pb_20081222.

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