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Relevant bibliographies by topics / A375 Melanoma cells, Onconase, PARP inhibitors, BRAF inhibitors

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Journal articles
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Academic literature on the topic 'A375 Melanoma cells, Onconase, PARP inhibitors, BRAF inhibitors'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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Journal articles on the topic "A375 Melanoma cells, Onconase, PARP inhibitors, BRAF inhibitors"

1

Raineri, Alice, Sara Prodomini, Sabrina Fasoli, Giovanni Gotte, and Marta Menegazzi. "Influence of onconase in the therapeutic potential of PARP inhibitors in A375 malignant melanoma cells." Biochemical Pharmacology 167 (September 2019): 173–81. http://dx.doi.org/10.1016/j.bcp.2019.06.006.

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De Tomi, Elisa, Rachele Campagnari, Elisa Orlandi, et al. "Upregulation of miR-34a-5p, miR-20a-3p and miR-29a-3p by Onconase in A375 Melanoma Cells Correlates with the Downregulation of Specific Onco-Proteins." International Journal of Molecular Sciences 23, no. 3 (2022): 1647. http://dx.doi.org/10.3390/ijms23031647.

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Onconase (ONC) is an amphibian secretory ribonuclease displaying cytostatic and cytotoxic activities against many mammalian tumors, including melanoma. ONC principally damages tRNA species, but also other non-coding RNAs, although its precise targets are not known. We investigated the ONC ability to modulate the expression of 16 onco-suppressor microRNAs (miRNAs) in the A375 BRAF-mutated melanoma cell line. RT-PCR and immunoblots were used to measure the expression levels of miRNAs and their regulated proteins, respectively. In silico study was carried out to verify the relations between miRNA

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3

Raineri, Fasoli, Campagnari, Gotte, and Menegazzi. "Onconase Restores Cytotoxicity in Dabrafenib-Resistant A375 Human Melanoma Cells and Affects Cell Migration, Invasion and Colony Formation Capability." International Journal of Molecular Sciences 20, no. 23 (2019): 5980. http://dx.doi.org/10.3390/ijms20235980.

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Melanoma is a lethal tumor because of its severe metastatic potential, and serine/threonine-protein kinase B-raf inhibitors (BRAFi) are used in patients harboring BRAF-mutation. Unfortunately, BRAFi induce resistance. Therefore, we tested the activity of onconase (ONC), a cytotoxic RNase variant, against BRAFi-resistant cells to re-establish the efficacy of the chemotherapy. To do so, an A375 dabrafenib-resistant (A375DR) melanoma cell subpopulation was selected and its behavior compared with that of parental (A375P) cells by crystal violet, 5-Bromo-2’-deoxyuridine incorporation, and cleaved p

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4

Hseu, You-Cheng, Yu-Chi Chiang, Yugandhar Vudhya Gowrisankar, et al. "The In Vitro and In Vivo Anticancer Properties of Chalcone Flavokawain B through Induction of ROS-Mediated Apoptotic and Autophagic Cell Death in Human Melanoma Cells." Cancers 12, no. 10 (2020): 2936. http://dx.doi.org/10.3390/cancers12102936.

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Melanoma is the most prevalent type of skin cancer with high mortality rates. This study demonstrates the in vitro and in vivo anticancer properties of chalcone flavokawain B (FKB) induced ROS-mediated apoptosis and autophagy in human melanoma (human epithelial melanoma cell line A375 and/or human skin lymph node derived melanoma cell line A2058) cells. Cell viability was calculated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and the expression patterns of various apoptosis, autophagy-associated proteins were determined by Western blot methods. Annexin V was det

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5

Johnson, Hannah, Amandeep Singh, Asif Raza, Satya Narayan, and Arun K. Sharma. "Abstract 5605: Development of a novel protein phosphatase 2A (PP2A) activator, PPA27, as a potential therapeutic for melanoma." Cancer Research 85, no. 8_Supplement_1 (2025): 5605. https://doi.org/10.1158/1538-7445.am2025-5605.

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Abstract Protein phosphatase 2A (PP2A) is a vital serine/threonine phosphatase acting as a tumor suppressor, often inactivated in melanoma and other cancers. This study builds upon our initial findings on the PP2A activators PPA24 and PPA27, focusing on extended in vitro and in vivo evaluations to assess PPA27's therapeutic potential against melanoma. In our previous work, both compounds demonstrated selective cytotoxicity in melanoma cell lines. Here, we further characterize PPA27’s efficacy across five melanoma cell lines (SK-MEL-2, SK-MEL-28, A375, Mel1241, and 451Lu), showing IC50 values r

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Dissertations / Theses on the topic "A375 Melanoma cells, Onconase, PARP inhibitors, BRAF inhibitors"

1

raineri, alice. "Influence of ONCONASE in the therapeutic potential of PARP and BRAF inhibitors in human A375 melanoma cells." Doctoral thesis, 2019. http://hdl.handle.net/11562/1016949.

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Melanoma is one of the most aggressive form of skin cancer, characterized by high mortality rate due to the metastatic potential of its cells. Several therapies have been approved during last few years. Recently, the melanoma molecular characterization led to development of drugs acting against specific targets. For instance, BRAF inhibitors (BRAFi) have been tested against BRAF-mutated melanoma. Unfortunately, all chemotherapy strategies failed for the resistance acquired by tumor cells. Poly (ADP-ribose) polymerase (PARP) enzymes are crucial in the DNA damage response and the PARP inhibitio

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