Dissertations / Theses: 'A3J'

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Jaguva, Vasudevan Ananda Ayyappan [Verfasser]. "APOBEC3 DNA deaminases: A mechanistic study of A3A, A3C, and A3G action on retroviruses and counteraction by viral proteins / Ananda Ayyappan Jaguva Vasudevan." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2017. http://d-nb.info/1148720936/34.

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Domingues, Alexandre Enéas. "Estudo das alterações moleculares do gene ABO em doadores de sangue fenotipados como A3 e A3B." Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/5/5136/tde-01082007-141215/.

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O sistema sanguíneo ABO é o mais importante grupo sanguíneo na medicina transfusional. Atualmente, a determinação do tipo sanguíneo dos doadores de sangue é feita através de testes sorológicos rotineiros de laboratório, porém outros testes realizados com o DNA humano obtido de amostra de sangue, tornam-se complementos valiosos para a determinação correta do grupo sanguíneo do doador e do receptor, aumentando a segurança transfusional. Estudos realizados com o grupo sanguíneo A3 e A3B demonstraram que este subgrupo possui um alto grau de heterogeneidade, uma vez que diversos eventos moleculares foram associados a ele, embora apenas um pequeno número de amostras tenha sido testado até hoje. Nesse trabalho, foi investigada a frequência e os tipos de eventos moleculares do grupo sanguíneo A3 e A3B em um grupo de 100 doadores de sangue. Para seleção desse grupo foram analisadas 12.283 amostras de doadores de sangue saudáveis de ambos os sexos do grupo sanguíneo A e AB obtidas na Fundação Pró-Sangue/Hemocentro de São Paulo, pelos métodos teste em tubo e gel teste. Obtiveram-se 13 amostras A3 e 87 amostras A3B. Após extração e quantificação do DNA genômico das amostras utilizou-se amplificação do DNA pela técnica de reação da polimerase em cadeia alelo específico (PCR-ASP) para as regiões 467C>T, 829G>A, 871G>A e 1060C>A (del C) do exon 7 do gene ABO. Os resultados de amplificação das regiões estudadas apontam para um novo genótipo, aqui denominado A30*/ , presente em 30,7% das amostras A3 e em 58,6% das amostras A3B (A30*/B10*) (necessária a confirmação por sequenciamento); detectou-se também o genótipo A302/A301 em 30,7% das amostras A3 e o genótipo A302/B104 em 17,1% das amostras A3B; outros genótipos já descritos para subgrupo A3 (A301/A301, A302/A302, uma amostra de cada) foram também verificados bem como presença da mutação na região 871G>A em 9 amostras A3 ; verificou-se também que mutações nas regiões 467 C>T e 1060 C>A (del C), anteriormente descritas somente em indivíduos A2 e A2B, são muito frequentes em indivíduos A3 e A3B. ABO blood system is the most important blood group in transfusional medicine. Actualy, the blood group type in blood donors and receptors is determined by serological laboratorial tests, complemented by human DNA blood tests that assure the correct blood group determination for the blood donor and receptor, optimizing transfusional safety. Studies on blood subgroup A3 e A3B demonstrated a large subgroup heterogenity, with various associated molecular changes in small sample groups tested. At present study, it was proposed investigation about the frequency and the types of molecular alterations occuring among 100 blood donors samples phenotyped as A3 e A3B. These samples are selected after tub and gel tests analysis of 12.283 A and AB samples of healthy blood donors of both sex from Fundação Pró-Sangue/Hemocentro de São Paulo. Thirteen A3 and 87 A3B samples were selected, each sample genomic DNA was extracted and quantified and it was performed DNA amplification by alellic specific polimerase chain reaction (PCR-ASP). It was studied exon 7 ABO gene mutations 467C>T, 829G>A, 871G>A and 1060C>A (del C). Amplification results pointed that a new genotipe is present at these A3 and A3B subgroup, named in this study as the A30*/ genotipe (sequencing confirmation needed); these genotipe is present in 30.7% A3 samples and in 58.6% A3B samples (A30*/B10*). However, it was detected the ulterior decrived genotipes: A302 present in 30.7% A3 samples (A302/A301) and in 17.1% A3B samples (A302/B104); for subgroup A3 it was observed the genotipes A301/A301, A302/A302 (one sample each) and the presence of 871G>A mutation at 9 A3 samples; 467 C>T and 1060 C>A (del C) exon 7 ABO gene mutations descrived at A2 e A2B samples, are very frequents at these A3 e A3B samples tested.

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Macaluso, Nicholas-Jacomo Maximilian. "Studies on the apelin/APJ system." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609383.

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Nishihara, Anderson. "Montagem assistida por realidade aumentada (A3R)." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/3/3152/tde-28092016-105248/.

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Processos de montagem em geral necessitam de instruções para serem executados, desde a montagem de simples brinquedos até máquinas complexas. Tradicionalmente, essas instruções vem na forma de manuais em papel ou meio digital. Seja qual for o modo, os manuais de instruções utilizam desenhos, diagramas ou fotos, além de instruções textuais para indicar a sequência de montagem do início até o estado final. Procurando mudar esse paradigma, esse trabalho propõe um sistema para auxílio à montagem que utiliza realidade aumentada para guiar o usuário no processo. Através de processamento de imagens capturadas por uma câmera o sistema reconhece cada peça e por meio de sinais gráficos é indicado ao usuário qual a peça a ser manipulada e onde deve ser posicionada. Em seguida é feito a verificação do posicionamento das peças e o usuário é alertado quando a tarefa de montagem atinge o estado final. Muitos trabalhos na área utilizam algum tipo de dispositivo customizado como \"head mounted display\" (HMD) e marcadores para auxiliar o rastreamento da câmera e identificação das peças, limitando a popularização dessa tecnologia. Tendo esse último ponto em vista, propõe-se um sistema que não utiliza qualquer dispositivo customizado ou marcadores para rastreamento. Além disso, todos os processos do sistema são executados em software embarcado, não necessitando de comunicação com outros computadores para o processamento de imagens. Como o sistema não faz uso de marcadores para a identificação das peças, inicialmente é proposto a implementação do sistema para guiar o usuário na resolução de um quebra-cabeças plano. O sistema proposto é denominado como MARA (Montagem Assistida por Realidade Aumentada). Assembly processes for simple toys or complex machines usually requires instructions to be executed. Traditionally, these instructions are written in the form of paper or digital manuals. These manuals contains descriptive text, photos or diagrams to guide the assembly sequence from the beginning to the final state. To change this paradigm, it is proposed in this work an augmented reality system to guide assembly tasks. The system recognizes each assembly piece through image processing techniques and guides the piece placement with graphic signals. Later, the system checks if the pieces are properly assembled and warns the user when the assembly have been finished. In the field of assembly assisted by augmented reality systems, many works use some kind of customized device, like head mounted displays (HMD). Furthermore, markers have been used to track camera position and identify assembly parts. These two features restrict the spread of the technology, thus in the proposed work customized devices and markers to track and identify parts shall not be used. Besides, all the processing are executed on embedded software without the need of communication with other computers to help image processing. The first implementation of the proposed system assists the user on the assembly of a planar puzzle, as the proposed system do not use markers to recognize assembly pieces. This system is being called A3R (Assembly Assisted by Augmented Reality).

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Lafrance, Mylène. "Relation structure-activité, distribution et fonctions des récepteurs couplés aux protéines G : NTS2 et APJ." Thèse, Université de Sherbrooke, 2014. http://hdl.handle.net/11143/5396.

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Les récepteurs couplés aux protéines G (RCPG) de classe A sont les cibles de plus de 25% des médicaments sur le marché et nombreux sont ceux impliqués dans le traitement de la douleur. Les enjeux dans les traitements de la douleur chronique est énorme puisque nombreux sont ceux qui ne répondent pas à la médication usuelle. La recherche de nouvelles avenues thérapeutiques est indispensable afin d’aider les patients dont le soulagement est limité. Le récepteur de la neurotensine de type 2 (NTS2) et le récepteur APJ de l’apéline sont deux RCPG qui pourraient être des cibles pour deux éventuels traitements contre la douleur. Les objectifs de cette thèse étaient de caractériser des analogues synthétiques ciblant les récepteurs NTS2 ou APJ, examiner la distribution de ces récepteurs dans le cerveau, la moelle épinière et les ganglions spinaux pour ensuite déterminer leur implication dans la régulation du contrôle descendant au niveau spinal et supraspinal dans la région bulbaire rostro-ventrale (RVM) en conditions de douleurs aiguë et tonique. Nous avons observé que l’immunoréactivité du récepteur NTS2 était distribuée dans l’axe rostrocaudal de la substance grise périaqueductal (SGPA) et dans tous les noyaux de la RVM. Les résultats sont similaires avec l’anticorps anti-APJ démontrant que ces deux récepteurs sont impliqués dans le contrôle de la douleur. Aussi, les résultats en immunohistochimie dans la moelle épinière ont illustré la présence du récepteur APJ dans les laminae superficielles. Dans les ganglions spinaux, APJ colocalise dans les neurones substance P. Les résultats aux tests comportementaux avec administration intra-RVM d’analogues modifiés neurotensinergiques ont montré une analgésie impliquée par l’activation de NTS2 dans la RVM. L’analgésie provoquée par le récepteur NTS2 serait médiée via la relâche de sérotonine au niveau de la moelle épinière en conditions de douleurs aiguë et tonique. Les résultats en douleur tonique avec les analogues Apeline-13 modifiés en position carboxy-terminale illustrent que les modifications comportant les groupements 2-naphtalenalanine (2 Nal) et de l’acide aminoisobutyrique (Aib) permettent une plus forte analgésie générale, cependant nos expériences à ce jour ne nous permettent pas de statuer sur les différentes voies de signalisation activées dans ces conditions. La modélisation moléculaire pourrait nous aider davantage afin d’explorer les différentes caractéristiques des ligands biaisés. Ces études sur la relation structure-activité, distribution et fonctions des récepteurs NTS2 et APJ dans la modulation de douleur ne sont qu’un début vers des nouveaux traitements contre la douleur.

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Vignola, Alex. "Abrasive water jet (AWJ): tecnologia, impianto e ruolo dell’abrasivo." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2018.

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La tecnologia water jet è una tecnologia piuttosto recente che però, negli ultimi decenni, ha avuto uno sviluppo davvero elevato; uno sviluppo continuo, a partire dagli anni 50, che non accenna ad arrestarsi, e che ha progressivamente migliorata la tecnologia, portandola ad essere una delle più versatili presenti sul mercato odierno. All’inizio fu utilizzata su materiali morbidi e con spessori limitati, come carta o plastica. La successiva introduzione dell’abrasivo, in aggiunta al getto d’acqua pressurizzato, ha portato alla possibilità di lavorare materiali e spessori di interesse ingegneristico.

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Steyn, Abraham Jacobus. "Karakterisering en evaluering van 'n hidrouliese enjinmonteerstuk / Steyn A.J." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7571.

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The engine mount system is an important aspect to achieve vibration isolation, and has a very important effect on the ride standards and noise in a vehicle's compartment. In this study a hydraulic engine mount was designed and built and two mathematical models were developed. The first mathematical model was used to determane the dynamic properties of the hydraulic engine mount as well as the rubber engine mountings for various frequencies and amplitudes. The dynamic properties were determined in a test assembly that was designed and build for this application. These dynamic properties were used to evaluate the vibration isolation. The second mathematical model was a two degree of freedom model that was developed and implemented in a computer programme in a Matlab environment. This programme was used to predict the natural frequencies for the vertical bounce and rotational mode by using the dynamic properties of the engine mountings. This second model was also used to predict the engine response and dynamic forces transmitted to the vehicle structure with the help of a computer program. The engine unbalance forces and fluctuating moments were determined with the use of certain parameters. The engine mass and the moment of inertia, as well as the coordinates and dynamic properties of the three engine mountings, were also determined and used as input in the computer programme. The predicted engine response was compared with corresponding measured values for the same conditions. The engine mountings must also be able to support the static weight of the engine, with allowable displacement at each mount. The static and dynamic displacement was determined for various operating conditions. Two engine mounting systems were evaluated in the test vehicle. The standard engine mounting system consists of three rubber engine mountings. The modified mounting system has two rubber mounts that were replaced with hydraulic engine mounts. Response measurements were taken on each of the engine mounting systems in the vertical direction respectively. The dynamic forces transmitted to the vehicle structure were determined and compared for the two mounting systems, by using this measured values as well as the mounting dynamic properties for different operational conditions. Sound measurements inside the vehicle cabin were also measured separately for the two mounting systems and compared with each other. This study shows that the hydraulic engine mount has a big improvement on the isolation system, and that the biggest benefit was at road inputs as operational conditions. Thesis (M.Ing. (Mechanical Engineering))--North-West University, Potchefstroom Campus, 2012.

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Robla, Sánchez Ignacio. "Wheel Wear Simulation of the Light Rail Vehicle A32." Thesis, KTH, Spårfordon, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-261228.

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During the last decade, a novel methodology for wheel wear simulation has been developed in Sweden. The practical objective of this simulation procedure is to provide an integratedengineering tool to support rail vehicle design with respect to wheel wear performance and detailed understanding of wheel-rail interaction. The tool is integrated in a vehicle dynamicssimulation environment.The wear calculation is based on a set of dynamic simulations, representing the vehicle, the network, and the operating conditions. The wheel profile evolution is simulated in an iterativeprocess by adding the contribution from each simulation case and updating the profile geometry.The method is being validated against measurements by selected pilot applications. To strengthen the confidence in simulation results the scope of application should be as wide aspossible in terms of vehicle classes. The purpose of this thesis work has been to try to extend the scope of validation of this method into the light rail area, simulating the light rail vehicleA32 operating in Stockholm commuter service on the line Tvärbanan.An exhaustive study of the wear theory and previous work on wear prediction has been necessary to understand the wear prediction method proposed by KTH. The dynamicbehaviour of rail vehicles has also been deeply studied in order to understand the factors affecting wear in the wheel-rail contact.The vehicle model has been validated against previous studies of this vehicle. Furthermore new elements have been included in the model in order to better simulate the real conditionsof the vehicle.Numerous tests have been carried out in order to calibrate the wear tool and find the settings which better match the real conditions of the vehicle.Wheel and rail wear as well as profile evolution measurements were available before this work and they are compared with those results obtained from the simulations carried out.The simulated wear at the tread and flange parts of the wheel match quite well the measurements. However, the results are not so good for the middle part, since themeasurements show quite evenly distributed wear along the profile while the results from simulations show higher difference between extremes and middle part. More tests would benecessary to obtain an optimal solution.

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Hubinger, Adriaan Johannes. "An appropriate leadership model for the banking industry / Hubinger A.J." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7362.

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This study aims to measure the managerial skills of managers working in the banking industry. To do so, the newly developed managerial skills measuring instrument of Thekiso (2011) was used by to determine skills for managerial competence in the banking industry. The seven managerial skills that are covered in the questionnaire are: Self awareness skills; Self directed career planning; Integrative skills; Planning and controlling skills; Organizing skills; Leading skills; and Managing change skills. Even though some skills may appear on a less frequent basis, six of the seven skills were rated to be of a high importance, with their means ranging between 4.008 and 4.480 on the 5–point Likert scale. Training in the form of mentoring and stewardship programs, to transfer knowledge and introduce existing relationships to up and coming leaders, would be of great value for companies in the banking industry to foster these seven managerial competency skills. By implementing training and mentoring programs on a much broader scale, organisations can train and use their leaders’ abilities to gain competitive advantage in the market. Thesis (M.B.A.)--North-West University, Potchefstroom Campus, 2012.

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Laranjeira, Hugo Miguel Marque. "Alternativa à transfusão homóloga, nas cirurgias ortopédicas ATJ e ATA." Master's thesis, Universidade de Aveiro, 2012. http://hdl.handle.net/10773/9660.

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Mestrado em Bioquímica As cirurgias ortopédicas, como a artroplastia total do joelho (ATJ) e a artroplastia total da anca (ATA) são responsáveis por grande perda de sangue, sendo necessário recorrer frequentemente a transfusões homólogas para a compensar. No entanto, para além das transfusões homólogas não serem isentas de riscos, são um recurso limitado e caro. Assim, como forma de reduzir as necessidades de transfusões homólogas, tem-se desenvolvido várias estratégias alternativas. A utilização de dispositivos que permitem a recuperação do sangue drenado do local cirúrgico e a sua reinfusão depois de filtrado está na base de uma dessas estratégias. No Centro Hospitalar do Baixo Vouga, E.P.E. – Aveiro recorre-se a esta abordagem usando os dispositivos Cell Trans™. O presente trabalho teve por objetivo verificar a eficácia do Cell Trans™ na ATJ e na ATA. Foram realizados dois estudos: A. Eficácia dos Cell Trans™ na ATJ e na ATA – um estudo retrospetivo e B. Eficácia da utilização do Cell Trans™ em pacientes submetidos a ATJ – um estudo prospetivo randomizado. No estudo A, com a implementação do Cell Trans™ 29% dos pacientes submetidos a ATJ e 38% dos pacientes submetidos a ATA receberam transfusão homóloga de concentrado de eritrócitos (CE), um número significativamente menor ao observado antes da sua implementação, 68% e 59%, respetivamente. Concomitantemente, verificou-se uma redução no tempo de internamento e um aumento nas unidades de CE pedidas e posteriormente devolvidas com a utilização destes dispositivos. No estudo B verificou-se que a utilização destes dispositivos mantém os pacientes com níveis de hemoglobina acima do limiar de transfusão, não exercendo efeitos significativos nas contagens de leucócitos e plaquetas. No entanto, aumentou o volume médio de sangue drenado de 1038mL para 1572mL em 48 horas, sendo reinfundidos em média 1089mL de sangue. Este estudo sugere que a utilização do Cell Trans™ no Centro Hospitalar Baixo Vouga, E.P.E. – Aveiro é uma prática positiva, reduzindo significativamente a necessidade de transfusão de CE e o tempo de internamento dos pacientes, sendo que a reinfusão de sangue recuperado do local cirúrgico com Cell Trans™ apresenta efeitos semelhantes à transfusão de CE. Estudos futuros envolvendo a análise de parâmetros bioquímicos indicativos de processos como ativação da coagulação, ativação da fibrinólise, ativação de leucócitos e ativação de plaquetas serão importantes para suportar a utilização com segurança deste dispositivo na prática clínica. As cirurgias ortopédicas, como a artroplastia total do joelho (ATJ) e a artroplastia total da anca (ATA) são responsáveis por grande perda de sangue, sendo necessário recorrer frequentemente a transfusões homólogas para a compensar. No entanto, para além das transfusões homólogas não serem isentas de riscos, são um recurso limitado e caro. Assim, como forma de reduzir as necessidades de transfusões homólogas, tem-se desenvolvido várias estratégias alternativas. A utilização de dispositivos que permitem a recuperação do sangue drenado do local cirúrgico e a sua reinfusão depois de filtrado está na base de uma dessas estratégias. No Centro Hospitalar do Baixo Vouga, E.P.E. – Aveiro recorre-se a esta abordagem usando os dispositivos Cell Trans™. O presente trabalho teve por objetivo verificar a eficácia do Cell Trans™ na ATJ e na ATA. Foram realizados dois estudos: A. Eficácia dos Cell Trans™ na ATJ e na ATA – um estudo retrospetivo e B. Eficácia da utilização do Cell Trans™ em pacientes submetidos a ATJ – um estudo prospetivo randomizado. No estudo A, com a implementação do Cell Trans™ 29% dos pacientes submetidos a ATJ e 38% dos pacientes submetidos a ATA receberam transfusão homóloga de concentrado de eritrócitos (CE), um número significativamente menor ao observado antes da sua implementação, 68% e 59%, respetivamente. Concomitantemente, verificou-se uma redução no tempo de internamento e um aumento nas unidades de CE pedidas e posteriormente devolvidas com a utilização destes dispositivos. No estudo B verificou-se que a utilização destes dispositivos mantém os pacientes com níveis de hemoglobina acima do limiar de transfusão, não exercendo efeitos significativos nas contagens de leucócitos e plaquetas. No entanto, aumentou o volume médio de sangue drenado de 1038mL para 1572mL em 48 horas, sendo reinfundidos em média 1089mL de sangue. Este estudo sugere que a utilização do Cell Trans™ no Centro Hospitalar Baixo Vouga, E.P.E. – Aveiro é uma prática positiva, reduzindo significativamente a necessidade de transfusão de CE e o tempo de internamento dos pacientes, sendo que a reinfusão de sangue recuperado do local cirúrgico com Cell Trans™ apresenta efeitos semelhantes à transfusão de CE. Estudos futuros envolvendo a análise de parâmetros bioquímicos indicativos de processos como ativação da coagulação, ativação da fibrinólise, ativação de leucócitos e ativação de plaquetas serão importantes para suportar a utilização com segurança deste dispositivo na prática clínica.

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Pecháček, Martin. "Hodnocení kvality povrchu při řezání u technologie AWJ a WJM." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2010. http://www.nusl.cz/ntk/nusl-228934.

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This study deals with technology of abrasive water jet material cutting and influence of cutting head feed rate on surface topography of cut walls with regards to roughness. Eight parameters were chosen based on the CSN EN ISO 4288 standard representing quality of surface after AWJ cutting. When AWJ cutting the chosen material – commercially pure ASTM B265 grade 2 titanium – feed rate was being changed and in order to obtain information about each parameter´s distribution in various depths of the cut, surface composition was evaluated. It was found out that feed rate has significant influence on surface and that the profile elements´ width grows when increasing the feed rate and cut depth. Furthermore, two selected feed rate results were compared to laser beam technology and conclusion for the selected material was made that AWJ cutting is more preferable due to final roughness and no heat affect on the material.

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Wagner, Marcia Fortes. "Evidências psicométricas do Cuestionário de Ansiedad Social para Adultos (CASO-A30)." Pontifícia Universidade Católica do Rio Grande do Sul, 2011. http://hdl.handle.net/10923/4979.

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Made available in DSpace on 2013-08-07T19:09:07Z (GMT). No. of bitstreams: 1 000431229-Texto+Completo-0.pdf: 2039560 bytes, checksum: b23755be5fd43c56c64c7985d290654e (MD5) Previous issue date: 2011 This thesis describes the process of adaptation process to Brazilian reality of the Social Anxiety Questionnaire for Adults (SAQ-A30) instrument for assessing the Social Anxiety Disorder (SAD) / Social Phobia. It is characterized by being part of a cultural study developed in the Ibero-American countries Argentina, Austrália, Bolívia, Brasil, Chile, Colômbia, Costa Rica, Espanha, Estados Unidos, Equador, Guatemala, México, Paraguai, Peru, Portugal, República Dominicana, Uruguai, e Venezuela, through a partnership with the University of Granada, Spain, with the coordinator Vicente Caballo PhD. . This is a project that integrates research line PROINSTRU: Development, Adaptation, Validation and Standardization of Psychological instruments to the Brazilian reality developed by the Research Group of Evaluation and Treatment in Cognitive Psychotherapy from the Post graduation Program in Psychology at the Pontifícia Universidade Católica do Rio Grande do Sul, coordinated by Margareth da Silva Oliveira PhD. The thesis consists in three sections, being the first theoretical, the second with empirical studies of psychometric properties and validity of the instrument, and the third section, with the application of the instrument before and after a brief group intervention. The first section presents the literature review entitled "Social skills in the context of Social Anxiety Disorder and Alcoholism," in which the SAD is conceptualized and are exploited association studies between SAD and alcohol dependence. The study investigated the main ideas discussed in the scientific field related to social skills deficits as a risk factor for development of clinical condition and concluded that one of the interventions that demonstrate efficacy may be the Social Skills Training.This intervention aims to equip the individual to develop social skills and interpersonal relationships more satisfying, stimulating coping strategies, problem solving, how to resist offers of alcohol and to say no. Section 2 presents an empirical study titled "Social Anxiety Questionnaire for Adults (SAQ-A30)", which aims to study the psychometric properties and describe the evidence of validity studies of the SAQ-A30, enabling it as a new instrument for assessment of social anxiety disorder. The sample consisted of 951 subjects, of whom 537 were women and 414 men, corresponding to 183 people in the clinical group and 768 in the general population. The average age of people was 28. 58 years (SD = 11. 39). The clinic population was organized into two groups: 82 subjects with SAD and 101 alcoholics. The SAQ-A30 had a Cronbach Alpha coefficient of 0. 93, demonstrating a highly satisfactory internal consistency. Factor analysis indicated the presence of five factors, as in the original studies of their authors, each one with six items and good internal consistency. Section 3 describes the study "Social skills training to use the SAQ-A30: intervention study group", which presents the results of a brief intervention group of Social Skills Training (SST) with students who have SAD. Through the application of SAQ-A30 before and after SST, we sought to determine whether the instrument is able to monitor behavioral changes in individuals, assessing the improvement in symptoms of SAD in subjects undergoing intervention. This thesis revealed that the SAQ-A30 in its Brazilian version presented the necessary requirements in terms of internal consistency and factorial validity to be widely used as a choice for the assessment of SAD both within the scientific research and in clinical practice. Esta tese de doutorado descreve o processo de adaptação para a realidade brasileira do Cuestionário de Ansiedad Social para Adultos (CASO-A30), instrumento de avaliação do Transtorno de Ansiedade Social (TAS)/Fobia Social(FS). Caracteriza-se por fazer parte de um estudo transcultural desenvolvido nos países iberoamericanos Argentina, Austrália, Bolívia, Brasil, Chile, Colômbia, Costa Rica, Espanha, Estados Unidos, Equador, Guatemala, México, Paraguai, Peru, Portugal, República Dominicana, Uruguai e Venezuela, por meio de uma parceria com a Universidade de Granada, na Espanha, tendo como coordenador o Professor Dr. Vicente Caballo. Trata-se de um projeto que integra a linha de pesquisa PROINSTRU: Desenvolvimento, Adaptação, Validação e Padronização de Instrumentos psicológicos à realidade brasileira desenvolvida pelo Grupo de Pesquisa Avaliação e Atendimento em Psicoterapia Cognitiva do Programa de Pós-Graduação em Psicologia da Pontifícia Universidade Católica do Rio Grande do Sul, coordenado pela professora Dra. Margareth da Silva Oliveira. A tese consta de três seções, sendo a primeira teórica, a segunda empírica com os estudos das propriedades psicométricas do instrumento e a terceira uma pesquisa com aplicação do instrumento antes e depois de uma intervenção grupal breve. A seção 1 apresenta a revisão de literatura intitulada “Habilidades sociais no contexto do Transtorno de Ansiedade Social e Dependência de Álcool”, na qual o TAS é conceitualizado e são explorados estudos de associação entre o TAS e a Dependência do Álcool. O estudo investigou as principais proposições discutidas no meio científico relacionadas ao déficit de habilidades sociais enquanto fator de risco ao desenvolvimento destes quadros clínicos e concluiu que uma das intervenções que demonstram eficácia pode ser o Treinamento de Habilidades Sociais.Tal intervenção visa instrumentalizar o indivíduo a desenvolver habilidades sociais e relações interpessoais mais satisfatórias, estimulando estratégias de enfrentamento, resolução de problemas, como resistir ao oferecimento de bebida alcoólica e conseguir dizer não. A Seção 2 apresenta um estudo empírico intitulado “Estudos de Adaptação do Cuestionário de Ansiedad Social para Adultos (CASO–A30)”, o qual tem o objetivo de estudar as propriedades psicométricas e descrever os estudos de evidência de validade do CASO-A30, viabilizando-o como um novo instrumento de avaliação do transtorno de ansiedade social. A amostra foi constituída de 951 sujeitos, dos quais 537 eram mulheres e 414 homens, correspondendo a 183 pessoas do grupo clínico e 768 de população geral. A média de idade das pessoas foi de 28,58 anos (DP= 11,39). A população clínica foi organizada em dois grupos: 82 sujeitos com TAS e 101 alcoolistas. O CASO-A30 obteve um coeficiente de Alfa de Cronbach de 0,93, demonstrando uma consistência interna altamente satisfatória. A análise fatorial indicou a presença de cinco fatores, tal como nos estudos originais de seus autores, cada um com seis itens e boa consistência interna. A Seção 3 descreve o estudo “Treinamento em habilidades sociais com uso do CASO-A30: estudo de intervenção grupal”, no qual são apresentados os resultados de uma intervenção breve grupal de Treinamento de Habilidades Sociais (THS) com universitários que possuem TAS. Através da aplicação do CASO-A30 antes e depois do THS, buscou-se verificar se o instrumento consegue monitorar mudanças de comportamento nos indivíduos, avaliando a melhora dos sintomas do TAS nos sujeitos submetidos à intervenção.Essa tese revelou que o CASO-A30 em sua versão brasileira apresentou os requisitos necessários em termos de consistência interna e validade fatorial para ser amplamente utilizado como escolha para a avaliação do TAS tanto no âmbito da pesquisa científica quanto na prática clínica.

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Formiga, Ângela Martins. "Estudo de novo conceito de haste intramedular para revisão da ATJ." Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13638.

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Mestrado em Materiais e Dispositivos Biomédicos Esta dissertação teve por objetivo estudar um novo conceito de haste intramedular para a cirurgia de revisão da artroplastia total do joelho, de modo a minimizar os efeitos negativos da sua utilização, como o efeito de stress-shielding e a dor sentida por alguns pacientes na zona da extremidade da haste, devido a sobrecarga localizada. Estes efeitos podem comprometer o sucesso da cirurgia de revisão e levar à necessidade de re-revisão. Na primeira fase deste estudo procedeu-se ao desenvolvimento de modelos numéricos de elementos finitos simples, com o intuito de avaliar como os diferentes parâmetros das hastes press-fit (comprimento, rigidez e geometria) influenciam os diferentes fatores biomecânicos associados, traduzidos pelo efeito de concentração de carga no osso adjacente à extremidade da haste, pela estabilidade e transferência de carga induzida pelo prato tibial. Em função dos resultados obtidos, foram desenvolvidos modelos de diferentes propostas de haste, sendo estas uma combinação de diferentes geometrias e materiais. Após a análise com modelos simples, foram selecionadas as melhores propostas de haste e, em conjunto com uma haste press-fit disponível comercialmente para a cirurgia de revisão, procedeu-se à avaliação experimental, através de cirurgias in-vitro, com recurso a uma tíbia em material compósito. Os resultados das extensões principais permitiram avaliar como os novos conceitos de haste press-fit podem modificar o comportamento estrutural do córtex tibial na região da extremidade da haste, assim como analisar o potencial efeito de stress-shielding, quando comparados com uma haste press-fit comercial. Estes resultados também serviram para validar os modelos numéricos da tíbia desenvolvidos na última etapa. Os modelos numéricos replicaram os modelos avaliados nos ensaios experimentais e permitiram analisar comparativamente as novas propostas de haste, em relação a parâmetros biomecânicos complementares não passíveis de análise com ensaios in-vitro. Com base nos resultados numéricos e experimentais, foi selecionado o novo conceito de haste que melhor parece assegurar um compromisso entre os diferentes parâmetros biomecânicos, referentes à redução do efeito de fulcro produzido pela extremidade da haste no osso (podendo este efeito ser associado à dor sentida pelos pacientes), à redução do efeito de stress-shielding (já que o mesmo pode estar relacionado com o problema de reabsorção óssea a termo) e à estabilidade adicional fornecida ao prato tibial (podendo este efeito estar associado à osteólise). Este modelo é a haste com núcleo em crómio-cobalto e periferia de polietileno. The main goal of this thesis is to study a new concept of intramedullary stem to apply in revision total knee arthroplasty, in order to minimize the negative effects of its use, like stress-shielding and the end-of-stem pain felt by some patients, due to fatigue bone damage. These effects can compromise the success of the surgical revision and lead to a re-revision. In the first step of this study, numerical finite-element models were developed to evaluate how the different press-fit stem parameters (length, stiffness and geometry) could influence different biomechanical factors, such as the load concentration effect in the stem tip adjacent bone, the stability and the load transfer given by the tibial tray. According to the obtained results, different stem models were developed, which are a combination of different geometries and materials. After models analysis, the best stems were selected and, together with a press-fit stem available for revision surgeries, its experimental evaluation was carried out through in-vitro surgeries using a synthetic tibia. The principal strains results allow us to evaluate how the new press-fit stem concepts can modify the structural behavior of the cortex at the end-of-stem, as well as analyze the stress-shielding effect, when compared with a commercial press-fit stem. These results are also useful to validate tibia numerical finite-element models which were developed in the last step. The numeric models replicated the experimental ones and allow the comparative analysis of the new stem proposals, when related to complementary biomechanical parameters, which are difficult to analyze through in-vitro tests. Based on experimental and numeric results, it was selected the new stem concept which seems to ensure a compromise between the different biomechanical parameters, regarding the reduction of the fulcrum effect produced by the stem in the bone (being this effect related to end-of-stem pain), the minimization of the stress-shielding effect (which can be related to bone reabsorption) and the additional stability given to the tibial tray (which may be associated to osteolysis). This model is the stem with the chrome-cobalt main body with a polyethylene coating.

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Aires, André Filipe Parreira. "Plano de marketing para a empresa A.J. Aires e Filhos Lda." Master's thesis, Instituto Superior de Economia e Gestão, 2017. http://hdl.handle.net/10400.5/15012.

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Mestrado em Marketing O trabalho aqui apresentado tem como finalidade a elaboração de um plano de marketing para a empresa A. J. Aires e Filhos Lda., uma empresa dedicada ao comércio de produtos para construção, agricultura e ferragens que opera no concelho de Ferreira do Alentejo há mais de 40 anos. Os objetivos principais deste trabalho passam por aumentar a qualidade do serviço prestado aos clientes B2B e B2C de forma a aumentar as vendas em 35% e 20% respetivamente, até final de 2018. A metodologia utilizada para neste projeto intitula-se de action research pois possibilitou desenvolver o trabalho de pesquisa enquanto em contacto com a empresa em atividade e simultaneamente a recolha de dados primários e secundários. Foram feitas entrevistas semiestruturadas aos sócios da empresa e a um responsável pelo departamento de compras de uma das empresas do concelho. Entre os dias 4 de Setembro de 2017 e 30 de Setembro de 2017 foi pedido aos clientes que preenchessem um questionário, de forma a aferir a qualidade do serviço baseado do modelo SERVQUAL de Parasuraman, Zeithaml e Berry (1988). Os resultados deste permitiram observar que existem algumas diferenças na avaliação de clientes empresariais e particulares, sendo que de modo geral os clientes mostram-se satisfeito com a qualidade do serviço, tendo a empresa de melhorar os aspetos tangíveis e de empatia. Desta forma, as ações de marketing elaboradas têm maior incidência no crescimento da empresa e no melhoramento da qualidade do serviço, dentro dos recursos disponíveis da empresa. The work hereby presented has the goal to achieve a marketing plan for the retail company A. J. Aires e Filhos Lda. a company founded more than 40 years ago in the county of Ferreira do Alentejo which sells mainly construction materials, agricultural materials and hardware products. The main objectives of this work are to increase the service quality and increase sales in B2B transactions in 35% and 20% in B2C transaction until the end of 2018. The methodology used in this project is action research in order to develop the research while simultaneously in contact with the company and being able to collect primary and secondary data. A couple of semi structured interviews were made to both partners of the company and to a customer's buying agent. Between the 4th of September 2017 and 30th of September of 2017 customers were asked to fill in a questionnaire based on the SERVQUAL model from Parasuraman, Zeithaml and Berry (1988). The results concluded that there are a few perception evaluation differences between B2B and B2C customers but generally both types of customers are satisfied with the quality of service although there is need to improve in tangible and empathy dimensions. Therefore, the produced marketing tactics are more focused in the company's growth and service quality improvement in the means of the company. info:eu-repo/semantics/publishedVersion

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Ahn, Seungki. "Some unsteady features of turbulent boundary layers." Thesis, Virginia Polytechnic Institute and State University, 1986. http://hdl.handle.net/10919/53090.

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For steady free-stream, zero and favorable pressure gradient turbulent boundary layers, the unsteadiness in the form of turbulent fluetuations was investigated. Phase ensemble-averaged flow characteristics of a large amplitude periodic unsteady turbulent boundary layer was also investigated at a redueed frequency k = 0.61 based on the length of the eonverging and diverging test section with amplitude to mean velocity ratio of 0.8. ln steady flow cases, both zero and favorable pressure gradient flows show good two—dimensional flow characteristics and mean flow characteristics are compared with other researchers’ data. Measured power spectral data show good agreement with those of Klebanoff, Ueda and Hinze, Perry, Lim and Henbest for the zero pressure gradient flows and Jones and Launder for the favorable pressure gradient flow. The power spectral data measured in the turbulent wall region of the zero pressure gradient flow closely follow the model equation proposed by Perry, Lim and Henbest. Convective wave speed also show good agreement with those of Favre, Gaviglio and Dumas and Sternberg within the experimental uncertainties. ln the inner region of the boundary layer where y+ < 40, convective wave speed is higher than local mean velocity at all eddy scales as observed by Kline, Reynolds, Schraub and Runstadler. In the unsteady flow case, in the absence of flow reversal, the flow behaves in a quasi-steady manner and can be described by the steady flow structure as in the case of moderate amplitude flows. The Ludwieg·Tillmann skin friction equation and the Perry-Schofield universal velocity defect law hold at these phases. Except the laminariscent velocity profile observed during the acceleration phases, the large amplitude unsteady flow shows basically the same flow characteristics as the moderate amplitude flows. Master of Science

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Clark, Seth. "A Framework of Design Tools Integration for Robotic Mechanisms." University of Akron / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=akron1133899346.

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Japp, Alan Gordon. "Cardiovascular effects of apelin in vivo in man." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8181.

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Background The apelin system is a novel peptidic pathway widely expressed in the heart and vasculature. In preclinical studies, apelin receptor agonism mediates nitric oxide-dependent vasodilatation, reduces ventricular preload and afterload and potently increases myocardial contractility. In preclinical models of heart failure, expression of the apelin pathway is down regulated but the haemodynamic effects of apelin receptor agonism are preserved. These changes in expression appear to be paralleled in patients with chronic heart failure but the cardiovascular actions of apelin in vivo in man are, to date, unknown. Detailed clinical investigation is therefore required to establish the role of apelin in human cardiovascular physiology and pathophysiology and to explore the therapeutic potential of apelin receptor agonism in patients with heart failure. Objectives Through a series of in vivo clinical studies: 1) to establish the direct vascular actions of apelin in the peripheral venous, peripheral arterial and coronary arterial circulations; 2) to determine the contribution of the endothelium-derived vasodilators, nitric oxide and prostacyclin, to the vascular actions of apelin; 3) to establish the effects of apelin on cardiac contractility and systemic haemodynamics; 4) to compare the direct vascular and systemic haemodynamic effects of the fulllength mature apelin peptide, apelin-36, with a shorter, biologically active carboxyl (C)-terminal fragment, (Pyr1)apelin-13); and 5) to establish whether the local vascular and systemic haemodynamic effects of apelin are altered in patients with chronic heart failure. Methods The cardiovascular effects of apelin were assessed in 32 healthy volunteers, 6 patients undergoing elective diagnostic coronary angiography, 18 patients with stable New York Heart Association (NYHA) class II-III chronic heart failure and 18 age- and sex-matched healthy controls. Dorsal hand vein tone was assessed by the Aellig hand vein technique during local intravenous infusions (0.1-3 nmol/min) of apelin-36, (Pyr1)apelin-13, and sodium nitroprusside (SNP; 0.6 nmol/min). Forearm blood flow was measured by venous occlusion plethysmography during intrabrachial infusions of apelin-36 and (Pyr1)apelin-13 (0.01-30 nmol/min) and subsequently in the presence or absence of a ‘nitric oxide clamp’ (nitric oxide synthase inhibitor, L-NG-monomethylarginine (L-NMMA; 8 μmol/min), co-infused with SNP (90-900 ng/min)), or a single oral dose of aspirin (600 mg) or matched placebo. Coronary blood flow was evaluated by quantitative coronary angiography (QCA) and Doppler flow wire, and left ventricular pressures measured by pressure wire before and after intracoronary injection of apelin-36 (20 and 200 nM), 0.9% saline and glyceryl trinitrate (GTN) (100 μg). Blood pressure, heart rate, cardiac output and peripheral vascular resistance were assessed by sphygmomanometry and thoracic electrical bioimpedance (TEB) during systemic intravenous infusion of apelin-36 and (Pyr1)apelin-13 (30-300 nmol/min). Forearm blood flow and systemic haemodynamic responses to (Pyr1)apelin-13 in patients with chronic heart failure were then compared with age- and sex-matched healthy controls. Results Although SNP caused venodilatation (P<0.0001), apelin-36 and (Pyr1)apelin-13 had no effect on dorsal hand vein diameter (P=0.2). Both apelin isoforms caused vasodilatation in forearm resistance vessels (P<0.0001) but the offset was slower with apelin-36. (Pyr1)apelin-13-mediated vasodilatation was attenuated by the nitric oxide clamp (P=0.004) but unaffected by aspirin (P=0.7). Intracoronary bolus of apelin-36 increased coronary blood flow and the maximum rate of rise in left ventricular pressure, and reduced peak and end-diastolic left ventricular pressures (all P<0.05). Both (Pyr1)apelin-13 and apelin-36 increased heart rate and cardiac output whilst reducing peripheral vascular resistance (P<0.01 for all) with no overall effect on blood pressure. Intrabrachial infusions of (Pyr1)apelin-13, acetylcholine and SNP caused forearm vasodilatation in patients and controls (P<0.0001 for all). Vasodilatation to acetylcholine (P=0.01) but not apelin (P=0.3) or SNP (p=0.9) was attenuated in patients with heart failure. Systemic infusions of (Pyr1)apelin-13 increased cardiac index and lowered mean arterial pressure and peripheral vascular resistance index in patients and matched controls (all P<0.01) but increased heart rate only in controls (P<0.01). Conclusions Although having no apparent effect on venous tone, acute apelin receptor agonism causes peripheral and coronary vasodilatation and increases cardiac contractility and output. Local vascular and systemic haemodynamic responses to apelin are preserved in patients with stable symptomatic chronic heart failure. The apelin system merits further clinical investigation to determine its role in cardiovascular homeostasis and represents a novel potential therapeutic target for patients with heart failure.

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Geldenhuys, Andries Johannes. "Water treatment technologies for removal of acid, sulphate and metals / A.J. Geldenhuys." Thesis, North-West University, 2004. http://hdl.handle.net/10394/666.

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Montgomery, Amanda Jane. "Burnout of primary school teachers in the North West Province / A.J. Montgomery." Thesis, North-West University, 2004. http://hdl.handle.net/10394/509.

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The foundation of the education of our country lies in the hands of the primary school teachers. Unfortunately, teachers have to juggle many roles - not only are they expected to teach diverse classes and be a role model, but they also have to deal with social problems - all for very little remuneration. Our teachers are becoming less motivated, frustrated and very despondent and as a result, an increasing number of teachers are suffering from burnout. The objective of this research was to investigate the job characteristics associated with burnout as well as the burnout-strain relationship among primary school teachers in the North-West Province. A stratified random sample of 646 primary school teachers in the North West Province was taken. The Maslach Burnout Inventory - General Survey (MBEGS), Job Characteristics Scale and Your Health Questionnaire (third questionnaire of the ASSET) were used as measuring instruments. Cronbach alpha coefficients, inter-item correlation coefficients, Pearsonproduct correlation coefficients and canonical correlation coefficients were used to analyse the data. Structural equation modelling (SEM) methods were used to construct job characteristic models of burnout. The results showed that overload leads to exhaustion, which leads to cynicism and in turn to lack of professional efficacy. Job resources was found to be related to all three dimensions of burnout, while rewards played a moderating effect between both overload and exhaustion, and job resources and burnout. Exhaustion and lack of professional efficacy lead to physical and psychological strain. Recommendations were made for further research. Thesis (M.Com. (Industrial Psychology))--North-West University, Potchefstroom Campus, 2004.

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Krüger, Andries Johannes. "Properties and use of SO2 for the hybrid sulfur process / Krüger A.J." Thesis, North-West University, 2011. http://hdl.handle.net/10394/7615.

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Thematic interrelation is an underdeveloped field of inquiry in Lukan studies. The design and elegance of Lukan theology begs for guided investigation into a possible system of organisation that governs history and theology, that is, narrative and theme. Based on the Greimasian Actantial Model, morpho–syntactical structural–critical analysis of Luke and Acts reveals that the covenant concept in its operative aspect of service functions as an organising principle, structuring the narratives and facilitating thematic interrelation. A survey of representative Lukan research consisting of five methodologically determined approaches shows a commonality regarding Lukan purpose. These all share the “plan of God” as a fundamental concept, thus intimating its plausibility as a common organisational principle in the text. This observation encourages further analysis of Lukan narrative and meta–narrative as relevant subject matter. Investigation into the purpose and goals of Ancient Jewish and Ancient Greek literature suggests that the concepts of piety/holiness and justness combined with a notion of divine order and expectation demonstrates organisational capacity. Under the terms and conditions of the Old Covenant three non–exclusive themes/concepts hold organisational functionality and ability to facilitate thematic interrelation: Exodus typology, the covenant concept and the eschaton idea. Exodus typology connects narrative with theme, developing Israel’s story. The covenant idea frames stories using parallelism and gives the meta–story progression. The eschaton idea presents the Day of YHWH as an organisational principle guiding the story of judgment to restoration. It is observed that the covenant concept is the most prevalent of these themes/ideas. Assuming the conceptual unity of Luke and Acts and adopting a morpho–syntactical structuralist approach, it was observed that the covenant concept in its operative aspect of service occurred as Helper at ten places, determining the development and structure of the meta–narrative. According to the Greimasian Actantial Model, Israel failed to fulfil its covenant–based mandate to serve God and shine God’s light of mercy to the nations. Jesus, Israel’s new Helper, becomes the Subject and by his covenant–based ministry, characterised as the greatest service, resolves the problem that prevents Israel from carrying out its divine mandate and sets the stage for its fulfilment. In Jesus Israel is given new leaders, an ethical platform of discipleship and the Holy Spirit. The apostle Paul as the epitomised and exemplary witness and servant of Jesus fulfils what Israel could not. He is vindicated in righteousness and shares in the Isaianic ministry of Jesus, to bear witness to leaders and to shine God’s light to the nations. Paul is unhindered in this ministry. Additionally, in thematic–critical terms, the key placement of the covenant concept in its operative aspect of service at plot–defining junctures features its catalytic dynamic as a “template” concept advancing the re–conceptualising of themes and providing a platform for meaningful relation. The evidence thus suggests that the covenant concept in its operative aspect structures the conjoined narratives of Luke and Acts. It also provides a basis for relation between the divine and humans in the context of the history of God’s salvation, linking history and theology, and makes possible a discernible means to thematic interrelation. The SO2 electrolysis was performed by supplying the anode of the cell with SO2 gas, while the water was fed to the cathode using graphite plates as flow fields. Initial experimental work was done at ambient pressures on the anode (SO2 gas–fed) and cathode (water–fed) after which the water pressure was increased from ambient to 1 bar. Various parameters were evaluated for SO2 electrolysis at ambient conditions, including operating temperature, membrane thickness and catalyst loading. The operating temperature was increased from 50oC to 80oC which resulted in a significant voltage improvement from 0.78V to 0.64V at 300mA/cm2. Operating the cell with thinner membranes (86 vs 170um) also resulted in an improved overall cell performance, while the catalyst loading (1 vs 0.5mgPt/cm2) had a negligible effect on the operating voltage. SEM images and EDX analysis were performed on the best performing MEA (N1135) which showed that no degradation of the MEA had occurred. Thesis (M.Sc. (Chemistry))--North-West University, Potchefstroom Campus, 2011.

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Dias, Andreia Le. "Gestão Ambiental na UFBA sob a perspectiva dos eixos temáticos da a3p." Instituto de Humanidades, Artes e Ciências Professor Milton Santos, 2014. http://repositorio.ufba.br/ri/handle/ri/16634.

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Submitted by ANDREIA DIAS (andreialedias@gmail.com) on 2014-11-13T14:20:47Z No. of bitstreams: 1 Dias_A_L_Dissertacao_versao final.pdf: 3055587 bytes, checksum: 3cee0813572bedef393727dd292b1cd1 (MD5) Approved for entry into archive by Alda Lima da Silva (sivalda@ufba.br) on 2014-11-18T21:55:52Z (GMT) No. of bitstreams: 1 Dias_A_L_Dissertacao_versao final.pdf: 3055587 bytes, checksum: 3cee0813572bedef393727dd292b1cd1 (MD5) Made available in DSpace on 2014-11-18T21:55:52Z (GMT). No. of bitstreams: 1 Dias_A_L_Dissertacao_versao final.pdf: 3055587 bytes, checksum: 3cee0813572bedef393727dd292b1cd1 (MD5) Essa dissertação tem como objetivo propor melhorias para o enfrentamento das questões ambientais no âmbito das Instituições de Ensino Superior (IES) cujos programas e projetos vêm sendo desenvolvidos de modo descentralizado e isolado. Trata-se de uma pesquisa exploratória, realizada através de um estudo de caso que teve como objeto a Universidade Federal da Bahia (UFBA), IES que vem praticando, de forma fragmentada, ações ambientais nos seus campi. Tendo em vista que a UFBA constitui um ente federal e, portanto, deve se submeter às orientações da Administração Pública Federal, neste trabalho buscou-se identificar as suas práticas ambientais sob a ótica das diretrizes da Agenda Ambiental na Administração Pública (A3P). Em tal contexto, verificou-se que a Universidade vem desenvolvendo ações que estão em consonância com os cinco eixos temáticos da A3P, porém algumas delas precisam ampliar o seu campo de atuação a fim de atender a complexidade que envolve a gestão ambiental em uma IES. A trajetória metodológica adotada nesse trabalho iniciou-se com a pesquisa bibliográfica envolvendo a temática dos eixos propostos pela A3P e da gestão ambiental, no panorama internacional e nacional. Em seguida, identificou-se as ações ambientais desenvolvidas na UFBA e realizou-se análises documentais e entrevistas com os atores responsáveis pela implantação de tais iniciativas, no intuito de verificar quais as principais atividades realizadas, bem como as dificuldades enfrentadas e os resultados alcançados e, por fim, procedeu-se a análise dos resultados. A partir das informações coletadas, foi possível perceber que as ações ambientais desenvolvidas na UFBA, além de proporcionarem benefícios ambientais, se traduzem em retornos econômicos significantes para a instituição. O programa “AGUAPURA”, por exemplo, através das ações de minimização de perdas e desperdícios da água, contribuiu para a redução de consumo de água em 36%, o que representou uma economia mensal na ordem de R$ 200.000,00. As ações do projeto “Consumo Consciente e Gestão de Resíduos Sólidos na EAUFBA” proporcionaram uma redução de aproximadamente 75% no consumo de papel e copo descartável em uma unidade da UFBA. Através do programa “POUPELUZ” foi possível o cumprimento da meta estabelecida pelo governo federal para a redução de energia no período da crise energética ocorrida no país em 2001. A “Usina Experimental de Compostagem da UFBA”, o “Recicle UFBA” e a “Campanha E-lixo: doando e ajudando” aplicaram esforços no sentido de contribuir para a gestão adequada dos resíduos gerados e o “Bem Viver” vem direcionando suas ações no intuito de proporcionar uma melhor qualidade de vida no trabalho do servidor da UFBA. Não obstante os resultados positivos alcançados, a maioria dessas iniciativas vem enfrentando dificuldades de sustentar suas atividades, principalmente pela falta de institucionalização dos projetos e programas implantados. Diante dessa constatação, verifica-se a necessidade premente de a UFBA incorporar em sua estrutura organizacional essas ações já iniciadas e, principalmente, inserir no rol das suas prioridades a questão ambiental, destinando, inclusive, cota do seu orçamento para essa finalidade. Faz-se mister, ainda, articular os esforços isolados em prol de uma postura mais integrada em relação à gestão socioambiental. This dissertation aims to propose improvements for dealing with environmental issues within Higher Education Institutions (HEI) whose programs and projects are being developed in a decentralized and isolated way. This is an exploratory research, carried out through a case study at Universidade Federal da Bahia (UFBA), who has been practicing scattered and piecemeal environmental actions in their campuses. Given that UFBA is a Brazilian federal entity and must therefore undergo the guidelines of the Brazilian Federal Public Administration, this study sought to identify their environmental practices from the perspective of the guidelines of the environmental agenda in Brazilian public administration (A3P). In such a context, it was noted that UFBA has been developing actions that are in line with the five themes of A3P, but some of them need to be reinforced and expand their field of action in order to cope with the complexity involved in environmental management in a HEI. The methodology adopted in this research began with a literature survey of the thematic axes proposed by A3P and environmental management at the international and national university scene. Then, environmental actions developed in UFBA were identified and documentary analysis and interviews with the actors responsible for the implementation of such initiatives were carried out in order to identify main activities, as well as the difficulties faced and the results achieved, and finally the results were analyzed. From the information collected, it was revealed that environmental actions developed in UFBA, in addition to providing environmental benefits, translate into significant economic returns for the institution. The “AGUAPURA” (PUREWATER) program, for example, through the actions of minimization of losses and waste of water, contributed to the reduction of water consumption by 36%, representing a monthly savings of R$ 200,000.00. The actions of the “Consumo Consciente e Gestão de Resíduos Sólidos na EAUFBA” (Conscious Consumption and Solid Waste Management in UFBA Business and Administration School) project provided an approximately 75% reduction in paper and disposable cup consumptions in an academic unit of UFBA. Through the “POUPELUZ” (SAVENERGY) program it was possible to achieve the target set by the Brazilian federal government to reduce energy during the energy crisis in the country in 2001. The “Usina Experimental de Compostagem da UFBA” (UFBA Experimental Composting Plant), the “Recicle UFBA” (UFBA, Recycle ) and the “Campanha E-lixo: doando e ajudando” (E-waste campaign: donating and helping) applied efforts to contribute to the proper management of waste generated at UFBA, and the “Bem Viver” (Well Living) has been directing their actions in order to provide a better quality of working life for UFBA workers and employees. Despite the positive results achieved, most of these initiatives has been facing difficulties to sustain their activities, especially due to the lack of institutionalization and UFBA support for the projects and programs implemented. Considering this fact, there is a pressing need that UFBA incorporates into your organizational structure these actions already initiated and mainly give priority to environmental issues, also allocating a part of its budget for this purpose. It is critical also to articulate the isolated efforts towards a more integrated approach regarding the environmental management.

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Resende, Carlos Alberto Pinho. "Estudo da substituição óssea com cunhas e enxertos no fémur na ATJ." Master's thesis, Universidade de Aveiro, 2013. http://hdl.handle.net/10773/11669.

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Mestrado em Engenharia Mecânica Nesta tese foi objetivo estudar os aspetos biomecânicos das diferentes técnicas de colmatação de perda óssea no fémur distal aquando da revisão da artroplastia total do joelho. Procurou-se avaliar como cada uma das diferentes técnicas altera a transferência de carga ao osso de suporte, aferindo assim potencias riscos de reabsorção óssea ou mesmo falha por fadiga do osso de suporte ou do material associado à técnica utilizada. Avaliou-se também o efeito da utilização da haste intramedular quando associada às diferentes técnicas. Para o efeito, numa primeira fase, realizou-se uma análise detalhada à articulação do joelho na vertente anatómica, biomecânica e artroplástica em especial no processo de revisão. Foi selecionada a prótese do joelho e respetivos aumentos protésicos do modelo comercial P.F.C. Sigma para a realização do estudo comparativo. Em complemento dos aumentos metálicos foram também avaliadas mais duas técnicas de colmatação óssea; uma com recurso ao cimento ósseo e outra com a utilização de um enxerto de osso. Para este processo desenvolveram-se modelos experimentais com recurso ao fémur em material compósito, onde os defeitos ósseos foram gerados de uma forma sequencial no côndilo medial e as diferentes técnicas de colmatação aplicadas através da realização de cirurgias "in-vitro". A fim de aferir as alterações de transferência de carga foram colocados extensómetros na região medial anexa ao defeito e lateral permitindo a avaliação das deformações principais no córtex sob ação de um severo caso de carga. Numa fase posterior desenvolveram-se modelos numéricos de elementos finitos que replicaram os modelos experimentais. Estes modelos numéricos permitiram a avaliação de parâmetros biomecânicos não passíveis de avaliação com recurso aos modelos experimentais anteriores, tais como as deformações no osso esponjoso de suporte e os níveis de tensão no cimento ósseo. Estes mesmos modelos foram comparados com os resultados obtidos nos modelos experimentais, evidenciando-se uma boa correlação entre estes. Os resultados obtidos nos modelos experimentais e numéricos demonstram alterações de transferência de carga para o osso de suporte entre os diferentes tipos de técnicas. As técnicas associadas ao aumento metálico distal de 4mm e cimento ósseo, para o defeito tipo F1, não alteram significativamente a transferência de carga para o osso suporte ao contrário das técnicas de aumento distal de 12mm e enxerto ósseo, para defeito tipo F2, estes apresentado riscos de reabsorção óssea e sobrecarga localizada respetivamente. O uso de haste femoral parece apenas ser útil associada à técnica com enxerto ósseo, sendo o seu efeito menos positivo quando associada as restantes técnicas. The main goal of this thesis, was studying the biomechanical behaviour of different techniques to replace bone loss in the distal femur at the revision total knee arthroplasty. The biomechanical behaviour of each technique was done by the evaluation of load transfer changes to the host bone, relating this changes with potential risk effects in host bone like bone resorption, due to stress-shielding effect, or bone fatigue damage due to localized overloading. Also was evaluated the use of an intramedullary press-fit stem in the load transfer effect to host bone, for each replacement technique. For this effect, in a first step, was done an anatomical and biomechanical review of the knee joint, as well as of the revision knee arthroplasty. For the study, P.F.C. Sigma knee prosthesis and femoral distal metal augments were selected, to carry the comparative study. In complement of the two distal metal augments, were also analyzed two more bone replacement techniques; bone cement filling and structural bone graft. For this comparative study were developed experimental models with composite femur, where of an incremental way bone defects type F1 and F2 were done at the medial condyle, and the different bone replacement techniques applied through in vitro surgeries'. The load transfer changes were analyzed in the experimental models with tri-axial strain gages positioned at the medial, next of the bone defect, and lateral cortex. The measured strains were used to calculate the maximal and minimal principal strain at the cortex surface under a severe load case. Later, were developed finite element models that replicate the experimental ones. These numerical models were used to evaluate the biomechanical parameters, which not possible to evaluate with the experimental models, as the principal strains in host cancellous bone and von Mises bone cement stress. These numerical models were correlated with the results of the experimental models, providing a good correlation between them. The experimental and numerical results showed load transfer changes at the host bone between the different replacement techniques. The metal 4mm augment and bone cement filling techniques, at the defect type F1, did not changes significantly the load transfer to the host bone, contrary to the techniques with metal 12mm augment and structural bone graft, applied at the bone defect F2, the latter presenting bone resorption and fatigue bone damage risks respectively. The femoral press-fit stem use appears only be beneficial associated at the structural bone graft technique, the stress-shielding effect generated by the stem limits their use with the others bone replacement techniques.

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Malát, Jan. "Technicko-ekonomické porovnání nekonvenčních technologií AWJ a LBM z hlediska potřeb firmy." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2011. http://www.nusl.cz/ntk/nusl-229944.

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This study deals with unconventional materials cutting technology with a fo-cus on abrasive water jet cutting and CO2 laser. The thesis is divided into theoretical and experimental section. The theoretical part describes principles and functions of nonconventional technologies, the basic division and practical applications. The practical part is focused on choosing the best technology with the production of samples and their subsequent comparison. The thesis recommends producer and type of the machine which best meets requirements on basis of the test results.

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Cortesi, Daniele. "Reinforcement Learning in Rogue." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/16138/.

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In this work we use Reinforcement Learning to play the famous Rogue, a dungeon-crawler videogame father of the rogue-like genre. By employing different algorithms we substantially improve on the results obtained in previous work, addressing and solving the problems that were arisen. We then devise and perform new experiments to test the limits of our own solution and encounter additional and unexpected issues in the process. In one of the investigated scenario we clearly see that our approach is not yet enough to even perform better than a random agent and propose ideas for future works.

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Ake, Timothy Nelson. "The evaluation of metham sodium and dichlobenil impacts on activated sludge nitrification." Thesis, This resource online, 1995. http://scholar.lib.vt.edu/theses/available/etd-06112009-063736/.

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Bonifácio, Wagner da Silva [UNESP]. "Sustentabilidade no campus: análise da relevância dos eixos temáticos da A3P – método brasileiro de práticas mais sustentáveis em instituições de ensino superior." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143763.

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Submitted by WAGNER DA SILVA BONIFACIO null (silva_wa@hotmail.com) on 2016-09-01T03:47:25Z No. of bitstreams: 1 DISS_MES_PEP_2016_07_06_WAGNER_DA_SILVA_BONIFACIO.pdf: 2999428 bytes, checksum: 2ccb63ff7e69729ee7df73e6cbf890ee (MD5) Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-09-01T19:57:53Z (GMT) No. of bitstreams: 1 bonifacio_ws_me_bauru.pdf: 2999428 bytes, checksum: 2ccb63ff7e69729ee7df73e6cbf890ee (MD5) Made available in DSpace on 2016-09-01T19:57:53Z (GMT). No. of bitstreams: 1 bonifacio_ws_me_bauru.pdf: 2999428 bytes, checksum: 2ccb63ff7e69729ee7df73e6cbf890ee (MD5) Previous issue date: 2016-07-06 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Este trabalho tem como objetivo sugerir melhorias no processo de implementação da A3P (Agenda Ambiental para Administração Pública). A proposta é analisar o seu composto, verificando-se, em sua adesão por Instituições de Ensino Superior (IES), se há alguma diferença nas contribuições das ações, sugeridas em seus Eixos e Variáveis, na promoção às práticas mais sustentáveis. Para responder a essa questão, adotou-se um framework que definiu etapas de condução dos trabalhos e desenvolvimento de pesquisa junto à Instituições de Ensino, campo da pesquisa. Realizou-se a revisão de literatura para indicar obtenção das publicações sobre o tema sustentabilidade e as suas métricas na Educação Superior bem como a caracterização da A3P. Através de um levantamento de campo buscou-se parâmetros definidos por especialistas no assunto, que ajustou o formato do Modelo de Referência da ferramenta ANP (Analytical Network Process), utilizada para tratar os dados coletados e chegar às conclusões, utilizando-se o software SUPERDECISION, específico para estudos de multicritério para modelagem do problema. Na consulta às IES que já adotaram a A3P, por meio de um instrumento de coleta de dados padronizado pelo formato ANP, os dados, à partir do software, foram analisados pelo modelo matemático proposto pela ferramenta. Como resultados, escalas numéricas para Eixos e Variáveis posicionam os mesmos entre si, definindo diferentes pesos para suas contribuições relativas às práticas mais sustentáveis com a adesão à Agenda. Como contribuição, foi sugerida melhoria no processo de implementação da A3P, definindo etapas para adesão em consonância com os resultados deste trabalho, através de um framework e um check-list de conduta. This paper aims to suggest improvements in the implementation process of A3P (Environmental Agenda for Public Administration). The proposal is to analyze your compound, checking up on its accession by Higher Education Institutions (HEIs), if there is any difference in the contributions of actions suggested in their axes and variables, to promote the most sustainable practices. To answer this question, we adopted a framework that defined driving stages of the work and research development with the education institutions, research field. We conducted a literature review to indicate obtaining publications on the subject of sustainability and its metrics in higher education as well as the characterization of A3P. Through a field survey sought to parameters defined by subject matter experts, who set the format of the ANP Tool Reference Model (Analytical Network Process), used to treat the collected data and reach conclusions using the SUPERDECISION software specific to multi-criteria studies for modeling the problem. In consultation with the HEIs that have adopted the A3P through an instrument of collecting standardized data by the ANP format, the data, from the software, were analyzed by the mathematical model proposed by the tool. As a result, numerical scales for axes and Variable position the same with each other by setting different weights for their relative contributions to more sustainable practices in the implementation of Agenda. As a contribution, it was suggested improvement in the implementation of A3P process, defining steps for membership in line with the results of this work through a framework and a checklist of conduct. CNPq: 134375/2014-9

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Sarmento, Neto José Ferreira. "Síntese de complexos de Mn(III) à base de porfirinas tricatiônicas do Tipo A3B (A = 2-N-metilpiridinio; B = 3-metoxi-4-hidroxifenil ou 3,4-dimetoxifenil) como potenciais mímicos das enzimas superóxido dismutases (SOD)." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/8985.

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Submitted by Maike Costa (maiksebas@gmail.com) on 2017-06-06T14:46:41Z No. of bitstreams: 1 arquivototal.pdf: 3774616 bytes, checksum: 0876fb49507ce01bcd8d4756cb29ba71 (MD5) Made available in DSpace on 2017-06-06T14:46:41Z (GMT). No. of bitstreams: 1 arquivototal.pdf: 3774616 bytes, checksum: 0876fb49507ce01bcd8d4756cb29ba71 (MD5) Previous issue date: 2016-09-15 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES The superoxide anion is among the reactive oxygen species closely related to physiopathological states associated with oxidative stress. The physiological superoxide levels are controlled in vivo by the superoxide dismutase enzymes (SOD). Pentacationic Mn porphyrins derived from 2-N-alkylpyridylporphyrins have been explored as potent SOD mimics and efficient redox modulators of oxidative stress. The in vivo efficiency of these compounds is related with their intrinsic catalytic activity, lipophilicity, bioavailability, and toxicity. The present study describes the synthesis of two A3B-type neutral porphyrins of low symmetry (A = 2-pyridyl, B = 3-methoxy-4-hydroxyphenyl or 3,4-dimethoxyphenyl), the methylation of these compounds to yield tricationic porphyrins and the preparation of the corresponding tetracationic Mn(III) porphyrins; overall, 8 new compounds are described: 5-(3-methoxy-4-hydroxyphenyl)-10,15,20-tris(2-pyridyl)porphyrin (H2VanTri-2-PyP), 5-(3,4-dimethoxyphenyl)-10,15,20-tris(2-pyridyl)porphyrin (H2MVanTri-2-PyP), 5-(3-methoxy-4-hydroxyphenyl)-10,15,20-tris(N-methylpiridinium-2-yl)porphyrin chloride (H2VanTriM-2-PyPCl3), 5-(3,4-dimethoxyphenyl)-10,15,20-tris(N-methylpiridinium-2-yl)porphyrin chloride (H2MVanTriM-2-PyPCl3), 5-(3-methoxy-4-hydroxyphenyl)-10,15,20-tris(2-pyridyl)porphinatomanganese(III) (MnVanTri-2-PyPCl), 5-(3,4-dimethoxyphenyl)-10,15,20-tris(2-pyridyl)porphinatomanganese(III) chloride (MnMVanTri-2-PyPCl), 5-(3-methoxy-4-hydroxyphenyl)-10,15,20-tris(N-methylpiridinium-2-yl)porphinatomanganese(III) chloride (MnVanTriM-2-PyPCl4) and 5-(3,4-dimethoxyphenyl)-10,15,20-tris(N-methylpiridinium-2-yl)porphinatomanganese(III) chloride (MnMVanTriM-2-PyPCl4). The spectroscopic, electrochemical properties and lipophilicity of all compounds were compared with A4-type 2-N-pyridyl porphyrin analogues. The monocationic compounds MnVanTri-2-PyP+ and MnMVanTri-2-PyP+ showed too low Mn(III)/Mn(II) reduction potential incompatible with superoxide dismuting activity, whereas the tetracationic complexes MnVanTriM-2-PyP4+ and MnMVanTriM-2-PyP4+ showed potential values suitable for the development these compounds as SOD mimics based on structure-activity relationships reported for analogous systems. The lipophilicity of MnVanTriM-2-PyP4+ and da MnMVanTriM-2-PyP4+ suggests promising bioavailability for in vitro and in vivo testing. O ânion radical superóxido constitui uma das espécies reativas de oxigênio intimamente relacionada a estados fisiopatológicos associados ao estresse oxidativo. Os níveis fisiológicos do superóxido são controlados in vivo pelas enzimas Superóxido Dismutases (SOD). Mn-porfirinas pentacatiônicas derivadas das 2-N-alquilpiridilporfirinas têm se destacado como mímicos potentes das enzimas SOD e, por sua vez, potentes moduladores redox de estresse oxidativo. A eficiência in vivo destes compostos está relacionada à atividade catalítica intrínseca, à lipofilicidade, à biodisponibilidade e à toxicidade. No presente estudo, descreve-se a síntese de 2 porfirinas neutras de baixa simetria do tipo A3B (A = 2-piridil, B = 3-metoxi-4-hidroxifenil ou 3,4-dimetoxifenil), a metilação destes compostos para obtenção de porfirinas tricatiônicas e a preparação das Mn(III) porfirinas tetracatiônicos correspondentes; ao todo são descritos 8 compostos inéditos: 5-(3-metoxi-4-hidroxifenil)-10,15,20-tris(2-piridil)porfirina (H2VanTri-2-PyP), 5-(3,4-dimetoxifenil)-10,15,20-tris(2-piridil)porfirina (H2MVanTri-2-PyP), cloreto de 5-(3-metoxi-4-hidroxifenil)-10,15,20-tris(N-metilpiridinio-2-il)porfirina (H2VanTriM-2-PyPCl3), cloreto de 5-(3,4-dimetoxifenil)-10,15,20-tris(N-metilpiridinio-2-il)porfirina (H2MVanTriM-2-PyPCl3), cloreto de 5-(3-metoxi-4-hidroxifenil)-10,15,20-tris(2-piridil)porfirinatomanganês(III) (MnVanTri-2-PyPCl), cloreto de 5-(3,4-dimetoxifenil)-10,15,20-tris(2-piridil)porfirinatomanganês(III) (MnMVanTri-2-PyPCl), cloreto de 5-(3-metoxi-4-hidroxifenil)-10,15,20-tris(N-metilpiridinio-2-il)porfirinatomanganês(III) (MnVanTriM-2-PyPCl4) e cloreto de 5-(3,4-dimetoxifenil)-10,15,20-tris(N-metilpiridinio-2-il)porfirinatomanganês(III) (MnMVanTriM-2-PyPCl4). As propriedades espectroscópicas, eletroquímicas e de lipofilicidade de todos os compostos foram comparadas com os derivados das 2-N-piridilporfirinas análogas do tipo A4. Os complexos monocatiônicos MnVanTri-2-PyP+ e MnMVanTri-2-PyP+ apresentam potenciais de redução Mn(III)/Mn(II) muito baixos para catalisarem a dismutação do superóxido, enquanto os complexos tetracatiônicos MnVanTriM-2-PyP4+ e MnMVanTriM-2-PyP4+ apresentaram potenciais apropriados para o desenvolvimento de mímicos SOD com base nas relações estrutura-atividade reportadas para sistemas correlatos. A lipofilicidade da MnVanTriM-2-PyP4+ e da MnMVanTriM-2-PyP4+ sugere que os compostos têm biodisponibilidade promissora para testes in vitro e in vivo.

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Walker, Simon Valentin. "Characterization of fatigue damage in A36 steel specimens using nonlinear Rayleigh surface waves." Thesis, Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/42753.

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A36 steel is a commonly used material in civil engineering structures where fatigue damage can lead to catastrophic failure. In this research, nonlinear Rayleigh surface waves are used to characterize damage in A36 steel specimens caused by monotonic tension and low cycle fatigue. Fatigue damage produces the increased acoustic nonlinearity that leads to the generation of measurable higher harmonics in an initially monochromatic Rayleigh wave signal. One specimen is subjected to static tension and four specimens are used for low cycle fatigue tests in the tension-tension mode with a constant stress amplitude. The fatigue tests are interrupted at different numbers of cycles for the nonlinear ultrasonic measurements. Tone burst Rayleigh wave signals are generated and detected using a pair of oil coupled wedge transducers. The amplitudes of the first and second harmonic are measured at varying propagation distances to obtain the nonlinearity parameter for a given damage state. The experimental results show an increase of acoustic nonlinearity in the early stages of fatigue life. Furthermore, a close relationship between plastic deformation and the acoustic nonlinearity is found, which indicates that the acoustic nonlinearity is indeed a measure of microplasticity in this material.

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Rehm, Kristina Roper Rachel. "The Poxvirus A35 Protein Promotes Virulence by Regulating the Host Adaptive Immune Response." [Greenville, N.C.] : East Carolina University, 2010. http://hdl.handle.net/10342/2696.

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Schutte, Abraham Jacobus. "Demand-side energy management of a cascade mine surface refrigeration system / A.J. Schutte." Thesis, North-West University, 2007. http://hdl.handle.net/10394/1843.

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The investigations focus on load shifting, load clipping and energy efficiency through control strategies. Load shifting is achieved by increasing the amount of work done in the Eskom non-peak period. This then results in a decrease in the Eskom peak time work load. The mine refrigeration system is modelled and verified with the data. A simulation is made from the model and the simulation is used to develop the new control strategy and new operational parameters. Predicted results are verified to be within production operational constraints. A case study was carried out to prove the effectiveness of the newly developed control strategy and operational parameters. Firstly the cascade mine surface refrigeration system is automated to allow remote viewing and control of the system from a central point. The control strategy is tested through implementation on automated mine refrigeration systems. The real-time energy management system (REMS) is set up and the communication with the SCADA is tested through observing dam level temperatures and stopping and starting refrigeration machines. The decisions the controllers make are monitored until the system is fully automated. The results of the new control system on the flows, temperatures, dam levels, thermal energy and electrical energy are validated and verified. An assessment of the case study proved that DSM can be done on cascade mine refrigeration systems. A 4.2 MW load shift was predicted and research found an over performance of 0.3 MW. It is clear from the results that utilising the thermal storage in cascade mine surface refrigeration systems, will allow DSM load shifting. In general, this dissertation proved DSM can be done on refrigeration systems and it is recommended that further studies be done on underground mine refrigeration systems. Thesis (M.Ing. (Mechanical Engineering))--North-West University, Potchefstroom Campus, 2008.

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Grenon, Marco. "Étude de la langue imagée québécoise générée par la structure comparative adj + comme /." Thèse, Chicoutimi : Université du Québec à Chicoutimi, 1993. http://theses.uqac.ca.

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Guilló, Recuerda Ana. "Relaciones filogenéticas del género Sarcocornia A.J. Scott (Amaranthaceae): implicaciones taxonómicas, evolutivas y biogeográficas." Doctoral thesis, Universidad de Alicante, 2013. http://hdl.handle.net/10045/28461.

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Tomes, J. H. "A.J. Balfour & British foreign policy : the international thought of a Conservative statesman." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334901.

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Adnan, Raja Abdul Aziz bin Raja. "Responses of mouse femoral bone marrow granulocyte-macrophage colony-forming cells (CM-CFC) to X-rays and restriction endonucleases." Thesis, University of St Andrews, 1987. http://hdl.handle.net/10023/13904.

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The effect of X-rays on mouse normal femoral bone marrow GM-CFC was compared using two different in vitro cell culture techniques - the agar colony assay and the radioisotope uptake assay (125IUdR or 3HTdR). The values obtained with the agar colony assay was 1.00 +/- 0.09 Gy and 2.10 +/- 0.10 Gy as measured by the radioisotope assay. Similar values were observed when the bone marrow cells were irradiated to vitro or to vivo. It was observed that the concentration of WEHI-3B conditioned medium (CSA) used in the agar colony assay would affect GM-CFC content of irradiated or normal bone marrow cells. But when optimum or greater levels of CSA were used the survival parameters plateaus. Pre-trypsinisation of bone marrow cells was not demonstrated to have modified the radiation survival characteristics of GM-CFC to X-rays and Do were not significantly different from GM-CFC from untreated bone marrow cells. Two distinct subpopulations of GM-CPC were observed based on their sensitivity to trypsin. One was survival-dose dependent and the other totally unaffected by increasing trypsin concentrations. Their ratio was approximately 1:1. Trypsin permeabilised murine bone marrow cells were treated with restriction endonucleases Pvu II and Bam HI. It was postulated that these endonucleases generated blunt-ended and cohesive-erided double-strand breaks (dsb), respectively. The cells were then assayed for their clonogenic ability to simulate GM-CFC death following X-ray exposure and to test the hypothesis that cell death arises from the induction of dsb in DNA via the formation of chromosomal aberrations. The results reported here show that Pvu II simulates X-ray exposure in causing a dose-dependent loss of the reproductive integrity of mouse femoral bone narrow GM-CPC, whilst Bam HI was found not to reduce cell survival even when concentrations greater than Pvu II were employed. These results support the idea that X-irradiated mammalian cells undergo a mode of death in which dsb in the DNA are lethal resulting in the loss of clonogenic ability. In contrast to previous experiments using inactivated Sendai virus, 0.001% trypsin was used to permeabilise the cells before treatment with the restriction endonucleases. However, when 0.05% trypsin was used Pvu II was shown not to further reduce the survival fraction of GM-CFC. The storage buffer containing the restriction endonucleases were found to be toxic but a region of tolerance was observed when the lower trypsin concentration was used. This had enabled the study of the effect of the restriction endonucleases on GM-CFC without the complicating presence of other forms of damage. From the D37 values, a dose of 142 +/- 4 units of Pvu II was equivalent to 1.20 Gy of X-rays (ie. 100 units = 0.85 Gy).

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Adkins, Treana. "The influence of sustaining feedback on the oral reading performance of low ability readers." Diss., Virginia Polytechnic Institute and State University, 1985. http://hdl.handle.net/10919/54176.

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The effects of teacher feedback on the reader's performance during oral reading have not been clearly delineated. This study was designed to investigate how two features of sustaining teacher feedback, type (graphophonemic and semantic) and timing (immediate and delayed) influence word recognition and comprehension for low ability second-grade readers. A sample of 9 low ability second-grade readers were selected and randomly assigned to one of 3 treatment sequence conditions. Each group received graphophonemic immediate prompts (The teacher immediately calls the readers attention to the deviation by pointing to the word and prompting, "Look closely at the letters in the word."); graphophonemic delayed prompts (The teacher prompts as above but after the reader has completed reading the sentence or a complete thought within a complex sentence.); and semantic delayed prompts (The teacher prompts the reader by asking, "Does that make sense?" after the reader has completed reading the sentence). A single—subject format (eg. A B A C A D A) was incorporated by using a Latin Square design for presenting the three treatment conditions to all three groups. On each of the twenty-three days the students orally read a different passage. Each treatment condition was conducted for approximately five fifteen minute reading sessions over a three week period. The four baselines had two sessions each. The dependent measures were literal comprehension and qualitative dimensions of word recognition, graphic similarity, semantic acceptability, and self-corrections. Results indicated that the treatments did not differentially affect the graphic similarity of the readers' responses, although the semantic delayed condition did encourage responses which were higher in semantic acceptability. In addition, the semantic delayed conditions influenced comprehension more positively than did the other conditions. Ed. D.

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Murza, Alexandre. "Synthèse et relations structure-fonction de nouveaux analogues de l'apéline-13." Thèse, Université de Sherbrooke, 2015. http://hdl.handle.net/11143/6857.

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L'apéline est le ligand endogène du récepteur APJ, un membre de la superfamille des récepteurs couplés aux protéines G. Le système apélinergique est apparu comme une cible prometteuse associée à plusieurs processus physiologiques. Notre intérêt s'est porté particulièrement sur les rôles liés au système cardiovasculaire et à la modulation de la douleur. Nous posons l'hypothèse que la synthèse d'analogues de l'apéline-13 nous permettrait d'identifier d'une part des composés plus stables et d'autre part les voies de signalisation impliquées dans la modulation de la douleur, les effets hypotenseurs et cardioprotecteurs de notre cible. Ces outils pharmacologiques contribueront ultimement à concevoir un agent thérapeutique pour le traitement de la douleur chronique et des maladies cardiovasculaires. Les données de relations structure-fonction de l'apéline-13 révèlent la présence de deux pharmacophores distants importants. Le fragment N-terminal Arg[indice supérieur 2]-Pro[indice supérieur 3]-Arg[indice supérieur 4]-Leu[indice supérieur 5] semble primordial pour l'affinité, alors que la Phe[indice supérieur 13] C-terminale serait cruciale pour l'internalisation du récepteur et les effets hypotenseurs. Afin de mieux comprendre les relations structure-fonction de l'apéline-13, nous avons synthétisé près d'une centaine d'analogues linéaires et macrocycliques. Les composés ont été évalués pour leurs capacités à lier APJ, à inhiber la formation d'AMPc, à recruter les β-arrestines et à activer les protéines Gα[indice inférieur i/o]. Une variété de modifications chimiques a été introduite en C-terminal, nous conduisant à la découverte de composés de haute affinité et puissance. Deux analogues, 1Nal[indice supérieur 13] et 2Nal[indice supérieur 13], se sont distingués pour leurs différences d'effets analgésiques dans un modèle in vivo de douleur tonique. Ces derniers présentent une intéressante divergence de sélectivité fonctionnelle suggérant que l'effet analgésique serait associé à un biais favorisant le recrutement des β-arrestines par rapport à l'inhibition de l'accumulation d'AMPc. Un autre volet du projet dédié à l'investigation de la stabilité plasmatique de l'apéline-13 nous a permis d'identifier son profil de dégradation protéolytique in vitro et in vivo. L'évaluation des demi-vies plasmatiques des analogues de l'apéline-13, modifiés à des positions clés, a révélé l'importance de l'acide aminé C-terminal dans la stabilité plasmatique. Enfin, une étude préliminaire de SAR par une approche macrocyclique novatrice du ligand endogène nous a conduit à un composé induisant un effet hypotenseur deux fois supérieur à celui de l'apéline-13. Un autre macrocycle a, quant à lui, démontré une sélectivité fonctionnelle inédite, n'activant pas la voie AMPc mais provoquant le recrutement de la β-arrestine2. Cette classe de molécules, potentiellement plus stables, a un grand potentiel pour nous aider à identifier les voies de signalisation liées aux effets physiologiques d'intérêts, et représente surtout un premier pas vers un futur agent thérapeutique.

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37

Strohbach, Anne [Verfasser]. "Die Bedeutung der endothelialen Mechanotransduktion für vaskuläre Implantate : das Apelin/APJ-System / Anne Strohbach." Greifswald : Universitätsbibliothek Greifswald, 2014. http://d-nb.info/1060136732/34.

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Strahl, Audra Lynne. "Characterization of temperature sensitive vaccinia virus mutants in the a3l and e6r complementation groups." [Gainesville, Fla.] : University of Florida, 2004. http://purl.fcla.edu/fcla/etd/UFE0005203.

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Thesis (M.S.)--University of Florida, 2004. Typescript. Title from title page of source document. Document formatted into pages; contains 59 pages. Includes Vita. Includes bibliographical references.

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39

Grosvenor, Peter Christopher. "A Medieval future : the social, economic and aesthetic thought of A.J. Penty (1875-1937)." Thesis, London School of Economics and Political Science (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.285151.

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This thesis is a comprehensive account and analysis of the contribution of architect and author A. J. Penty to British social criticism and aesthetic theory. The central argument is that Penty has been neglected in scholarship as the result of an historical misclassification. In the existing literature he is presented as a marginal figure in the history of English guild socialism, a movement his first book did much to inspire. He was, in fact, in conflict with fundamental aspects of the guild socialist movement as it developed. Considered in totality, Penty's views were those of a reactionary conservative, and his significance in early twentieth-century political thought can best be understood by locating him within the essentially Victorian tradition of medievalism, which sought to use the social and economic arrangements of the Middle Ages as a perspective from which to criticise industrial society. The thesis therefore investigates the complex nature of Penty's intellectual debts to earlier thinkers, such as Ruskin, Carlyle, Morris, Carpenter, and Matthew Arnold. A subsidiary contention is that the continuing relevance of medievalism in Edwardian and later intellectual life has been underestimated. Some of its central themes can be discerned in the several political currents with which Penty was in varying degrees associated, such as guild socialism, distributism, Christian social action, agrarian revivalism and fascism. Support for this view has been found by examining Penty's personal and intellectual links with likeminded contemporaries, including Belloc, Chesterton, de Maeztu, Saunders Lewis, T. S. Eliot, Berdyaev and A. K. Coomaraswamy.The thesis aims to highlight the continuities between Penty and his nineteenth-century antecedents and also to identify his original contributions to the development of medievalist thinking, particularly in the sphere of international relations theory. 3 2

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Hanekom, Albertus Johannes. "Die ontwerp en aanwending van 'n selfkonsep as praktykteorie vir pastorale berading / Hanekom, A.J." Thesis, North-West University, 2005. http://hdl.handle.net/10394/902.

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This study introduces a self concept that can serve as practice theory for pastoral counselling. The practical theological model of Zerfass is used to develop a basis, meta and practice theory. The basis theoretical perspectives indicate that the self may be viewed as the culmination of al the dimensions of perception of man. Three dimensions of the self may be distinguished, after the analogy of man as creation of God. -lmago Dei as structure/condition before God - man as the image of God - this emphasizes man's worth as creation of God. -lmago Dei as relational concept - man as a relationship being -this is essentially about experiencing love (security) in relationship with God, fellow man and nature. -lmago Dei as functional concept - man as representative of God -this essentially deals with the position in which man is appointed as representative of God. As a result of the fall of man the image of God in man is scarred and he exists in a condition of: -Shame (as the opposite of worth); -Fear (as the opposite of love); and -Guilt (as the opposite of position). Through the process of regeneration God creates a new person and in so doing restores man's worth in Christ. Through reconciliation in Christ God restores the love (security) within relationships as He had in mind before the fall. God acquits the person in Christ Jesus and restores the saved person's position as representative of God. Although man possesses love (security) and position in Christ, a bipolar tension exist between: -Worth and shame; -Love (security) and fear; and -Position and guilt. According to the meta theoretical perspectives man is a social creature and his/her self comes to fulfilment (with)in relationships. Man finds himself in a certain environment and circumstances and as such is subject to external influences. Man's need for security must be heeded in order for the self to realize its full potential. A safe place for genuineness, respect, and empathy must be created to actualise the self. Seeing that children learn through imitation, it is the responsibility of adults to be admirable role models for children. These perspectives raise an appeal to the human intellect. Man's intellectual/cognitive dimension therefore plays an important role in man's self. Finally, guidelines for the design and application of a practice theory for the application of a self-concept for pastoral counselling are suggested. Thesis (M.A. (Practical Theology))--North-West University, Potchefstroom Campus, 2006.

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Theunissen, Abraham Jacobus. "Die onderskeid tussen seerowery en terrorisme as versekerde risiko's in die seeversekeringreg / A.J. Theunissen." Thesis, North-West University, 2009. http://hdl.handle.net/10394/6394.

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Wagner, Marcia Fortes. "Evid?ncias psicom?tricas do Cuestion?rio de Ansiedad Social para Adultos (CASO-A30)." Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2011. http://tede2.pucrs.br/tede2/handle/tede/757.

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Made available in DSpace on 2015-04-14T13:21:54Z (GMT). No. of bitstreams: 1 431229.pdf: 2039560 bytes, checksum: b23755be5fd43c56c64c7985d290654e (MD5) Previous issue date: 2011-02-28 Esta tese de doutorado descreve o processo de adapta??o para a realidade brasileira do Cuestion?rio de Ansiedad Social para Adultos (CASO-A30), instrumento de avalia??o do Transtorno de Ansiedade Social (TAS)/Fobia Social(FS). Caracteriza-se por fazer parte de um estudo transcultural desenvolvido nos pa?ses iberoamericanos Argentina, Austr?lia, Bol?via, Brasil, Chile, Col?mbia, Costa Rica, Espanha, Estados Unidos, Equador, Guatemala, M?xico, Paraguai, Peru, Portugal, Rep?blica Dominicana, Uruguai e Venezuela, por meio de uma parceria com a Universidade de Granada, na Espanha, tendo como coordenador o Professor Dr. Vicente Caballo. Trata-se de um projeto que integra a linha de pesquisa PROINSTRU: Desenvolvimento, Adapta??o, Valida??o e Padroniza??o de Instrumentos psicol?gicos ? realidade brasileira desenvolvida pelo Grupo de Pesquisa Avalia??o e Atendimento em Psicoterapia Cognitiva do Programa de P?s-Gradua??o em Psicologia da Pontif?cia Universidade Cat?lica do Rio Grande do Sul, coordenado pela professora Dra. Margareth da Silva Oliveira. A tese consta de tr?s se??es, sendo a primeira te?rica, a segunda emp?rica com os estudos das propriedades psicom?tricas do instrumento e a terceira uma pesquisa com aplica??o do instrumento antes e depois de uma interven??o grupal breve. A se??o 1 apresenta a revis?o de literatura intitulada Habilidades sociais no contexto do Transtorno de Ansiedade Social e Depend?ncia de ?lcool, na qual o TAS ? conceitualizado e s?o explorados estudos de associa??o entre o TAS e a Depend?ncia do ?lcool. O estudo investigou as principais proposi??es discutidas no meio cient?fico relacionadas ao d?ficit de habilidades sociais enquanto fator de risco ao desenvolvimento destes quadros cl?nicos e concluiu que uma das interven??es que demonstram efic?cia pode ser o Treinamento de Habilidades Sociais. Tal interven??o visa instrumentalizar o indiv?duo a desenvolver habilidades sociais e rela??es interpessoais mais satisfat?rias, estimulando estrat?gias de enfrentamento, resolu??o de problemas, como resistir ao oferecimento de bebida alco?lica e conseguir dizer n?o. A Se??o 2 apresenta um estudo emp?rico intitulado Estudos de Adapta??o do Cuestion?rio de Ansiedad Social para Adultos (CASO A30), o qual tem o objetivo de estudar as propriedades psicom?tricas e descrever os estudos de evid?ncia de validade do CASO-A30, viabilizando-o como um novo instrumento de avalia??o do transtorno de ansiedade social. A amostra foi constitu?da de 951 sujeitos, dos quais 537 eram mulheres e 414 homens, correspondendo a 183 pessoas do grupo cl?nico e 768 de popula??o geral. A m?dia de idade das pessoas foi de 28,58 anos (DP= 11,39). A popula??o cl?nica foi organizada em dois grupos: 82 sujeitos com TAS e 101 alcoolistas. O CASO-A30 obteve um coeficiente de Alfa de Cronbach de 0,93, demonstrando uma consist?ncia interna altamente satisfat?ria. A an?lise fatorial indicou a presen?a de cinco fatores, tal como nos estudos originais de seus autores, cada um com seis itens e boa consist?ncia interna. A Se??o 3 descreve o estudo Treinamento em habilidades sociais com uso do CASO-A30: estudo de interven??o grupal, no qual s?o apresentados os resultados de uma interven??o breve grupal de Treinamento de Habilidades Sociais (THS) com universit?rios que possuem TAS. Atrav?s da aplica??o do CASO-A30 antes e depois do THS, buscou-se verificar se o instrumento consegue monitorar mudan?as de comportamento nos indiv?duos, avaliando a melhora dos sintomas do TAS nos sujeitos submetidos ? interven??o. Essa tese revelou que o CASO-A30 em sua vers?o brasileira apresentou os requisitos necess?rios em termos de consist?ncia interna e validade fatorial para ser amplamente utilizado como escolha para a avalia??o do TAS tanto no ?mbito da pesquisa cient?fica quanto na pr?tica cl?nica.

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Lima, Sidarta Ruthes de. "Análise prospectiva de políticas públicas (A3P): o caso do setor de software do Paraná." Universidade Tecnológica Federal do Paraná, 2016. http://repositorio.utfpr.edu.br/jspui/handle/1/2030.

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Existem muitas evidências da efetividade dos estudos prospectivos na iniciativa privada, no entanto, esta afirmação não pode ser extrapolada para a realidade do setor público. Atualmente, pesquisadores da área prospectiva buscam compreender como os estudos de futuro são utilizados na análise de políticas públicas, e qual sua efetividade em todo o processo. Hipóteses relacionadas aos ciclos políticos não explicam totalmente os resultados não alcançados com a prospectiva, pois alguns governos que perduraram no poder também não obtiveram resultados satisfatórios. Evidencia-se que os estudos prospectivos são utilizados na etapa inicial da análise de políticas públicas, ou seja, na formação de agenda, não avançando de forma mais veemente para as demais etapas do processo. Diante deste contexto, o problema que norteou esta tese pode ser assim caracterizado: como a abordagem prospectiva poderia ser mais efetiva no desenvolvimento de políticas públicas? Nesse sentido, esta tese tem como objetivo propor uma abordagem prospectiva que seja mais efetiva no desenvolvimento de políticas públicas. Trata-se de um estudo exploratório-descritivo, na forma de um estudo de caso (Setor de Software da Região Metropolitana de Curitiba). Ao todo foram entrevistados 68 atores, sendo 34 empresários e empreendedores do setor de software e 34 atores relacionados à política setorial (policy makers). Como resultado, destaca-se a necessidade de uma abordagem mais concreta, baseada no conceito da Proatividade Realista, ou seja, uma prospectiva factível e alinhada ao contexto político-institucional. O estudo evidencia que há a necessidade de aproximação entre os grupos de interesse (policy makers e policy users), reduzindo as divergências de entendimento do processo de desenvolvimento de políticas públicas setoriais. A falta de conhecimento das questões institucionais que envolvem as políticas públicas cria uma prospectiva idealista, baseada em anseios e lamentações. Finalmente, sugere-se uma alteração no modelo prospectivo, com a inserção de uma etapa de validação do estudo junto aos policy makers e o estabelecimento de um processo de governança. There is much evidence of the effectiveness of prospective studies (Foresight) in the private sector. However, this statement may not be extrapolated to the reality of the public sector. Currently, researchers from prospective area want to understand how future studies are used in the policy analysis, and what is its effectiveness in the whole process. Hypothesis related to political cycles do not fully explain the not achieved results with Foresight because some governments that remained in power also did not obtain satisfactory results. Prospective studies are used in the initial stage of policy analysis, in other words, on the agenda setting, not advancing consistently to the remaining steps of the process. Given this context, the issue that guided this thesis can be characterized as: how the prospective approach could be more effective in developing public policies? In this sense, this thesis aims to propose a prospective approach more effective in the development of public policies. This is an exploratory-descriptive study, in the form of a case study (Software Sector of the Metropolitan Region of Curitiba). Sixty-eight actors were interviewed: 34 business owners and entrepreneurs of the software sector and 34 actors related to sectoral policy (policy makers). The results indicated the need for a more concrete approach based on the Realistic Proactivity concept, in other words, a foresight approach feasible and aligned with the political and institutional context. The study also shows that there is a need of approach stakeholders (policy makers and policy users), reducing differences in understanding the development process of sectoral public policies. Lack of knowledge of institutional issues involving public policies creates an Idealistic Foresight approach, based on wishes and lamentations. Finally, a change in the prospective model is suggested, with the insertion of a study validation stage by the policy makers and the establishment of a governance process.

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44

Mughal, Amreen. "Regulation of Vascular Tone in Cerebral and Coronary Arteries by Apelin/APJ Receptor Mechanisms." Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/27847.

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The peptide, apelin, is expressed in fat cells, endothelial cells, and CNS neurons. Increasing evidence (e.g. inotropic and vasomotor effects) supports a role for apelin in the regulation of the cardiovascular system. This research aimed to understand vascular effects of apelin and bridge gaps in the knowledge about apelin-induced effects on different vascular beds i.e. cerebral and coronary arteries. My first objective was to assess apelin-induced vascular effects in cerebral arteries. Based on current data, one could conclude that apelin by itself has no effects on vasomotor tone of cerebral arteries, but it does impair nitric oxide dependent relaxations of cerebral arteries, possibly by inhibiting functions of large conductance calcium activated potassium (BKCa) channels. Apelin increases coronary blood flow; however, the involved mechanism(s) has not yet been elucidated. Hence, my next aim was to determine the mechanism(s) involved in apelin-induced vascular effects. The results suggest that apelin causes endothelium APJ receptor dependent relaxation of coronary arteries, which is possibly mediated by nitric oxide dependent direct activation of BKCa channels. Interestingly, my results also suggest that pathways involved in apelin-induced coronary arteries relaxation are markedly different from another endothelium dependent vasodilator, acetylcholine. This research is the first to report that nitric oxide, generated in response to different stimuli, can likely activate more than one signaling pathways in coronary arteries. In my final aim, I determined effects of apelin on smooth muscle BKCa channel functions in coronary arteries. My data suggest that functionally active apelin-APJ signaling has no inhibitory effects on BKCa channel functions and does not inhibit nitric oxide-induced relaxations of coronary arteries. Possible reasons for difference in apelin response between cerebral and coronary arteries could be associated with differences in activation of G-proteins and PI3K signaling pathways between these two vascular beds. Altogether, this research provides an improved understanding about apelin-induced vascular effects in cerebral and coronary arteries, and highlights some key mechanistic differences in apelin-induced vascular effects between these two blood vessels. Moreover, this knowledge may have important therapeutic implications in future design and development of apelin analogs for treatment of cardiovascular diseases. NIH National Heart, Lung and Blood Institute (HL124338)

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Pingili, Ajeeth Kumar. "Augmented Expression of Apelin/APJ in the Paraventricular Nuclei of Rats after Myocardial Infarction." Diss., North Dakota State University, 2012. https://hdl.handle.net/10365/26749.

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Heart failure (HF) is a disease condition in which insufficient blood is pumped through the body. The pathophysiology of HF is multisystematic and includes a collection of different responses to compensate for the inability of the heart to pump the blood with the most important outcome being increased sympathetic nervous system (SNS) activity. Increased SNS activity leads to reclaim the reserved cardiac function. However, this adaptive response is short term and deleterious. The central mechanisms that lead to increased SNS activity during conditions of HF remain enigmatic. APJ, a G-protein-coupled receptor and its endogenous ligand, is a novel neuroendocrine system. Previous studies from us and others indicated that central administration or over expression of apelin in brain cardiovascular regulatory areas resulted in an increase in blood pressure, sympathetic nerve activity and cardiac hypertrophy. The main objective of this study is to determine whether the Apelin/APJ system is involved in increased SNS activation during HF. We created HF rat models by left coronary artery ligation. Apelin and APJ receptor mRNA levels were measured in cardiovascular regions of the brain of sham and myocardial infarction (MI) rats. Results showed a significant increase in the levels of Apelin/APJ mRNA levels in paraventricular nuclei (PVN) and rostral ventrolateral medulla (RVLM) in MI rats as compared to sham rats. To determine the functional role of elevated APJ receptor in these cardiovascular regulatory regions of the brain during HF, we constructed a lentiviral vector carrying an APJ shRNA (Lenti-APJ-shRNA) to knockdown the APJ receptor. Efficiency of the lentiviral vector to knockdown the APJ receptor was confirmed in vitro by transducing a Cath.a cell line and a primary neuronal cell culture with Lenti-APJ-shRNA. In order to determine the effect of silencing of the APJ receptor in vivo, Lenti-APJ-shRNA virus was injected into the PVN of the MI and sham rats. Results showed knockdown of APJ receptor improved left ventricular function and decreased myocardial fibrosis and hypertrophy in MI rats. Thus, this study shows that PVN plays an important role in sympatho excitation and pathophysiology of HF and these findings may help in developing effective therapies for HF.

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46

Cortinez, Camila. "A3 acondicionamiento por aspersión de aire." Tesis, Universidad de Chile, 2010. http://repositorio.uchile.cl/handle/2250/100161.

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Chile es un país principalmente productor y exportador del área silvoagropecuaria. Debido al cambio climático que afecta al mundo, las temperaturas ideales que ofrecía nuestro país para el desarrollo de esta área se han visto afectadas, aumentando en verano y disminuyendo en invierno. Esto provoca que la calidad de cada cepa varíe; cambiando su acidez, su grado de madurez y las temperaturas que afectan de mayor manera a la vid son las bajas, ya que no sólo dañan su calidad, sino que también, pueden llegar a quemar un cultivo completo. La manera de controlar las heladas, es a través de numerosos sistemas pasivos o activos que utilizan agua, energía eléctrica o combustibles fósiles para su funcionamiento, estos sistemas son muy costosos y emiten gases invernadero u otros tipos de contaminantes, que no contribuyen al mejoramiento del medio ambiente. Debido a las necesidades de ahorro de energía y descontaminación, se han desarrollado tecnologías para optimizar el acondicionamiento de hogares y edificios, utilizando combinaciones de energías renovables y eléctrica, (basándose en el intercambio de temperatura) de tal forma que se optimiza el rendimiento de los equipos y disminuye su costo de utilización. Gracias a este desarrollo, han surgido sistemas de acondicionamiento eficientes y limpios que están siendo utilizados en construcciones tanto particulares como industriales. Se ha evaluado la posibilidad de extrapolar estos sistemas de acondicionamiento de hogares para que puedan ser implementados en la agricultura, y así, disminuir el costo económico asociado al daño de los cultivos. vitivinícolas en un porcentaje considerable. Al determinar esta posibilidad, se abre una brecha de oportunidades para el control de la temperatura de cosechas, ampliando no sólo para el control de heladas, si no para el acondicionamiento durante periodos de altas temperaturas.

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Penven, Jean-François. "Hémochromatoses secondaires et l'alléle Hla A3." Montpellier 1, 1988. http://www.theses.fr/1988MON11239.

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48

Maclean, Linda MacArthur. "The role of executive attention in healthy older adults' concurrent walking and counting." Thesis, University of St Andrews, 2013. http://hdl.handle.net/10023/4435.

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Completing activities of daily life relies on using both cognitive and physical resources efficiently, but these are affected by age. This may be due either to an age-related reduction in the resources we have available for carrying out tasks or to a reduction in our ability to use these resources efficiently. These resources comprise a set of processes called executive functions (EF), which collectively allow us to plan, initiate and monitor our performance of activities. Control and allocation of these resources is attributed to a central mechanism, sometimes called the central executive or executive attention, but the parameters that determine how resources are allocated are not well understood. Even simple or apparently automatic activities, such as walking, require attention, meaning that when task demands increase, for example when walking and speaking on the phone, there is a loss of efficiency in both tasks. The dual-task (DT) paradigm is an empirical means of examining the way attentional resources are allocated between two tasks by comparing their performance together in relation to how well they are carried out singly. Asking people to perform a cognitive task, such as counting backwards or spelling, while walking provides a reasonably naturalistic way to examine how flexibly older adults can divide their attention between the two tasks. Manipulating the demands of the task, either by increasing the difficulty of the cognitive task or instructing the participants to focus on one task or the other (prioritisation) should illuminate the strategies they use to allocate their available attention between the two tasks ask task demands vary. To explore this hypothesis a cohort of physically and cognitively healthy community-dwelling older adults (mean age = 72.3 years) took part in three studies. In the first experiment, 72 participants completed 8 single and dual-task conditions with varying cognitive load (counting back in 3s and 7s) and attention prioritisation (no prioritisation, prioritising walking and prioritising counting). Instructing the participants to prioritise walking in the DT when counting back in 7s produced the best walking and counting performance and this was predicted their score on a standardised measure of cognitive flexibility. In second part of the study, 68 of the participants were tested 12 months later when there was improvement in both their single and dual-task performances. There was also decline in concurrent walking and counting performance, but only when attention was allocated to walking in preference to the cognitive task. Both the improvements and the decline in performance after the 12-month period were predicted by a standardised test for EF at T1. In the third study a separate group of older adults (73.2 years) was trained to walk rhythmically to music, to further investigate the external manipulation of resource-allocation during concurrent walking and counting. Their performances were compared to 2 control groups who did not receive the same intervention procedures. Overall findings from this doctoral research demonstrate that explicitly manipulating attention-allocation during concurrent walking and cognitive activity improved healthy older adults' walking and counting performance and this was strongly associated with better cognitive flexibility. After 12 months, subtle decline in ability to allocate attention to walking during the DT, when attentional-demands were high, was also predicted by cognitive flexibility in an EF task. Together, these findings illuminated the role of executive attention in a rapidly-changing complex task when the ‘wrong' prioritisation could result in a fall. Observing healthy older adults' cognitive flexibility in allocating attention to walking, when required, revealed that executive attention was key to the future maintenance of their current functional well-being.

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49

Ahn, Taejin. "Optimal design of municipal and irrigation water distribution systems." Diss., Virginia Tech, 1993. http://hdl.handle.net/10919/38649.

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In two-dimensional flow, the point of flow separation from the surface coincides with the point at which the skin friction vanishes. However, in three-dimensional flow, the situation is much more complex and the flow separation is rarely associated with the vanishing of the wall shear stress except in a few special cases. Though the effects of cross-plane separation are substantial and have been recognized for some time, the phenomenon of flow separation over three-dimensional bodies is still far from being completely understood. The flow is so complex that no completely satisfactory analytical tools are available at the moment. In an attempt to logically identify the various effects and parametric dependence while simultaneously minimizing configuration dependent issue, the flow over a 6 to 1 prolate spheroid, which is a generic three-dimensional body, is investigated. For the identification of the general flow pattern and better understanding of the flow field, surface-oil-flow visualization tests and force and moment tests were performed. The angle of attack effect and Reynolds number effect on the separation location are studied with natural transition. Forces and moments tests, surface pressure distribution measurements as well as the surface pressure fluctuations, and mini-tuft flow visualization tests were made to document the flow characteristics on the surface of the body with an artificial boundary layer trip. Ph. D.

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Atuobi, Ampadu Christiana. "Pathogen Reduction on Selected Vegetables Using Hydrogen Peroxide." Bowling Green State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1182285352.

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Dissertations / Theses on the topic 'A3J'

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