Relevant bibliographies by topics / AAC LC

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  2. Dissertations / Theses
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  4. Conference papers

Academic literature on the topic 'AAC LC'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "AAC LC"

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Lu, Ming-ying, Li-li Zhang, Guo-yu Wang, Hong-sheng Zhang, and Liang-wei Li. "AAC LC Decoder Design Optimization for Low-power Portable DAB Radio." Journal of Electronics & Information Technology 33, no. 5 (2011): 1229–33. http://dx.doi.org/10.3724/sp.j.1146.2010.01028.

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Shikano, Hiroaki, Masaki Ito, Masafumi Onouchi, et al. "Heterogeneous Multi-Core Architecture That Enables 54x AAC-LC Stereo Encoding." IEEE Journal of Solid-State Circuits 43, no. 4 (2008): 902–10. http://dx.doi.org/10.1109/jssc.2008.917531.

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Engler, Michael, Guido Rüsing, Fritz Sörgel, and Ulrike Holzgrabe. "Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry." Antimicrobial Agents and Chemotherapy 42, no. 5 (1998): 1151–59. http://dx.doi.org/10.1128/aac.42.5.1151.

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ABSTRACT Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the structure of one product which is believed to be 8-desfluorosparfloxacin. The second product is likely to be formed by the splitting off of a fluorine and a cyclopropyl ring. Thus, photodefluorination of quinolone antibacterial agents is found and proved for the first time by LC-MS/MS.
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Novotna, G., and J. Janata. "A New Evolutionary Variant of the Streptogramin A Resistance Protein, Vga(A)LC, from Staphylococcus haemolyticus with Shifted Substrate Specificity towards Lincosamides." Antimicrobial Agents and Chemotherapy 50, no. 12 (2006): 4070–76. http://dx.doi.org/10.1128/aac.00799-06.

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ABSTRACT We found a new variant of the streptogramin A resistance gene, vga(A)LC, in clinical isolates of Staphylococcus haemolyticus resistant to lincomycin and clindamycin but susceptible to erythromycin and in which no relevant lincosamide resistance gene was detected. The gene vga(A)LC, differing from the gene vga(A) at the protein level by seven amino acid substitutions, was present exclusively in S. haemolyticus strains resistant to both lincosamides and streptogramin A (LSA phenotype). Antibiotic resistance profiles of the ATP-binding cassette (ABC) proteins Vga(A)LC and Vga(A) in the antibiotic-susceptible host S. aureus RN4220 were compared. It was shown that Vga(A)LC conferred resistance to both lincosamides and streptogramin A, while Vga(A) conferred significant resistance to streptogramin A only. Detailed analysis of the seven amino acid substitutions, distinguishing the two related ABC proteins with different substrate specificities, identified the substrate-recognizing site: four clustered substitutions (L212S, G219V, A220T, and G226S) in the spacer between the two ATP-binding cassettes altered the substrate specificity and constituted the lincosamide-streptogramin A resistance phenotype. A transport experiment with radiolabeled lincomycin demonstrated that the mechanism of lincosamide resistance in S. haemolyticus was identical to that of the reported macrolide-streptogramin B resistance conferred by Msr(A).
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Dijkstra, J. A., A. J. Voerman, B. Greijdanus, D. J. Touw, and J. W. C. Alffenaar. "Immunoassay Analysis of Kanamycin in Serum Using the Tobramycin Kit." Antimicrobial Agents and Chemotherapy 60, no. 8 (2016): 4646–51. http://dx.doi.org/10.1128/aac.03025-15.

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ABSTRACTKanamycin is one of the aminoglycosides used in the treatment of multidrug-resistant tuberculosis. Blood concentrations of kanamycin are predictive for the treatment efficacy and the occurrence of side effects, and dose adjustments can be needed to optimize therapy. However, an immunoassay method for the quantification of kanamycin is not commercially available. We modified the existing tobramycin immunoassay to analyze kanamycin. This modified method was tested in a concentration range of 0.3 to 80.0 mg/liter for inaccuracy and imprecision. In addition, the analytical results of the immunoassay method were compared to those obtained by a liquid chromatography-tandem mass spectrometry (LC-MS/MS) analytical method using Passing and Bablok regression. Within-day imprecision varied from 2.3 to 13.3%, and between-day imprecision ranged from 0.0 to 11.3%. The inaccuracy ranged from −5.2 to 7.6%. No significant cross-reactivity with other antimicrobials and antiviral agents was observed. The results of the modified immunoassay method were comparable with the LC-MS/MS analytical outcome. This new immunoassay method enables laboratories to perform therapeutic drug monitoring of kanamycin without the need for complex and expensive LC-MS/MS equipment.
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Zhu, Xin, Anshan Shan, Zhi Ma, et al. "Bactericidal Efficiency and Modes of Action of the Novel Antimicrobial Peptide T9W against Pseudomonas aeruginosa." Antimicrobial Agents and Chemotherapy 59, no. 6 (2015): 3008–17. http://dx.doi.org/10.1128/aac.04830-14.

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ABSTRACTThe antipseudomonal efficiency and mechanism of action of a novel engineered antimicrobial peptide, T9W, were evaluated in this study. T9W displayed high activity, with a lethal concentration (LC) of 1 to 4 μM againstPseudomonas aeruginosa, including against ciprofloxacin-, gentamicin-, and ceftazidime-resistant strains, even in the presence of 50 to 300 mM NaCl, 1 to 5 mM Ca2+, or 0.5 to 2 mM Mg2+. The time-kill curve (TKC) analysis demonstrated concentration-dependent activity, with T9W achieving complete killing in less than 30 min at 1× LC and in less than 5 min at 4× LC. Combination TKC analyses additionally demonstrated a synergistic effect with ciprofloxacin and gentamicin. The selectivity of T9W was further supported by its ability to specifically eliminateP. aeruginosain a coculture with macrophages without toxicity to the mammalian cells. The results from fluorescent measurement indicated that T9W bound to lipopolysaccharide (LPS) and inducedP. aeruginosamembrane depolarization, and microscopic observations and flow cytometry further indicated that T9W targeted theP. aeruginosacell membrane and disrupted cytoplasmic membrane integrity, thereby causing cellular content release leading to cell death. This study revealed the potential usefulness of T9W as a novel antimicrobial agent againstP. aeruginosa.
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Roxas-Duncan, Virginia, Istvan Enyedy, Vicki A. Montgomery, et al. "Identification and Biochemical Characterization of Small-Molecule Inhibitors of Clostridium botulinum Neurotoxin Serotype A." Antimicrobial Agents and Chemotherapy 53, no. 8 (2009): 3478–86. http://dx.doi.org/10.1128/aac.00141-09.

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ABSTRACT An integrated strategy that combined in silico screening and tiered biochemical assays (enzymatic, in vitro, and ex vivo) was used to identify and characterize effective small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A (BoNT/A). Virtual screening was initially performed by computationally docking compounds of the National Cancer Institute (NCI) database into the active site of BoNT/A light chain (LC). A total of 100 high-scoring compounds were evaluated in a high-performance liquid chromatography (HPLC)-based protease assay using recombinant full-length BoNT/A LC. Seven compounds that significantly inhibited the BoNT/A protease activity were selected. Database search queries of the best candidate hit [7-((4-nitro-anilino)(phenyl)methyl)-8-quinolinol (NSC 1010)] were performed to mine its nontoxic analogs. Fifty-five analogs of NSC 1010 were synthesized and examined by the HPLC-based assay. Of these, five quinolinol derivatives that potently inhibited both full-length BoNT/A LC and truncated BoNT/A LC (residues 1 to 425) were selected for further inhibition studies in neuroblastoma (N2a) cell-based and tissue-based mouse phrenic nerve hemidiaphragm assays. Consistent with enzymatic assays, in vitro and ex vivo studies revealed that these five quinolinol-based analogs effectively neutralized BoNT/A toxicity, with CB 7969312 exhibiting ex vivo protection at 0.5 μM. To date, this is the most potent BoNT/A small-molecule inhibitor that showed activity in an ex vivo assay. The reduced toxicity and high potency demonstrated by these five compounds at the biochemical, cellular, and tissue levels are distinctive among the BoNT/A small-molecule inhibitors reported thus far. This study demonstrates the utility of a multidisciplinary approach (in silico screening coupled with biochemical testing) for identifying promising small-molecule BoNT/A inhibitors.
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Klomchit, Anthikan, Jorge Daniel Calderin, Wuttichai Jaidee, Kanchana Watla-iad, and Siraprapa Brooks. "Napthoquinones from Neocosmospora sp.—Antibiotic Activity against Acidovorax citrulli, the Causative Agent of Bacterial Fruit Blotch in Watermelon and Melon." Journal of Fungi 7, no. 5 (2021): 370. http://dx.doi.org/10.3390/jof7050370.

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Bacterial fruit blotch (BFB) is a bacterial disease that devastates Cucurbitaceae crops worldwide, causing significant economic losses. Currently, there is no means to treat or control the disease. This study focused on exploring the antibacterial properties of endophytic fungi against Acidovorax citrulli (Aac), the causative agent of BFB. Based on disc diffusion, time kill and MIC microdilution broth assays, four endophytes showed promise in controlling Aac. Nonetheless, only one strain, Neocosmospora sp. MFLUCC 17-0253, reduced the severity of disease on watermelon and melon seedlings up to 80%. Structure analysis revealed production of several compounds by the fungus. Three of these secondary metabolites, including mixture of 2-methoxy-6-methyl-7-acetonyl-8-hydroxy-1,4-maphthalenedione and 5,8-dihydroxy-7-acetonyl-1,4-naphthalenedione, anhydrojavanicin, and fusarnaphthoquinones B exhibited antagonistic activity against Aac. The chemical profile data in planta experiment analyzed by LC-Q/TOF-MS suggested successful colonization of endophytic fungi in their host plant and different metabolic profiles between treated and untreated seedling. Biofilm assay also demonstrated that secondary metabolites of Neocosmospora sp. MFLUCC 17-0253 significantly inhibited biofilm development of Aac. To the best of our knowledge, secondary metabolites that provide significant growth inhibition of Aac are reported for the first time. Thus, Neocosmospora sp. MFLUCC 17-0253 possesses high potential as a biocontrol agent for BFB disease.
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van Rijn, S. P., A. M. A. Wessels, B. Greijdanus, D. J. Touw, and J. W. C. Alffenaar. "Quantification and Validation of Ertapenem Using a Liquid Chromatography-Tandem Mass Spectrometry Method." Antimicrobial Agents and Chemotherapy 58, no. 6 (2014): 3481–84. http://dx.doi.org/10.1128/aac.00025-14.

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ABSTRACTErtapenem, a carbapenem, relies on time-dependent killing. Therapeutic drug monitoring (TDM) should be considered, when ertapenem is used in specific populations, to achieve optimal bactericidal activity and optimize drug-dosing regimens. No validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been reported using deuterated ertapenem as the internal standard. A new simple and robust LC-MS/MS method using a quadrupole mass spectrometer was developed for analysis of ertapenem in human plasma, using deuterated ertapenem as the internal standard. The calibration curve was linear over a range of 0.1 (lower limit of quantification [LLOQ]) to 125 mg/liter. The calculated accuracy ranged from −2.4% to 10.3%. Within-run coefficients of variation (CV) ranged from 2.7% to 11.8%, and between-run CV ranged from 0% to 8.4%. Freeze-thaw stability had a bias of −3.3% and 0.1%. Storage of QC samples for 96 h at 4°C had a bias of −4.3 to 5.6%, storage at room temperature for 24 h had a bias of −10.7% to −14.8%, and storage in the autosampler had a bias between −2.9% and −10.0%. A simple LC-MS/MS method to quantify ertapenem in human plasma using deuterated ertapenem as the internal standard has been validated. This method can be used in pharmacokinetic studies and in clinical studies by performing TDM.
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Lee, Jae Kyung, Young-Jin Kim, and Choon Sik Cho. "Multiband multistandard frequency synthesizer for mobile TV tuner with LC-VCO by digital AAC." Microwave and Optical Technology Letters 58, no. 8 (2016): 1838–41. http://dx.doi.org/10.1002/mop.29918.

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Dissertations / Theses on the topic "AAC LC"

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Sampaio, Renato Coral. "Coprojeto de um decodificador de áudio AAC-LC em FPGA." reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/15175.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Exatas, Departamento de Ciência da Computação, 2013.
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A Codificação de áudio está presente hoje nos mais diversos aparelhos eletrônicos desde o rádio, a televisão, o computador, os tocadores de música portáteis e nos celulares. Em 2007, o governo do Brasil definiu o padrão do Sistema Brasileiro de TV Digital (SBTVD) que adotou o AAC Advanced Audio Coding para codificação de áudio. Neste trabalho, utilizamos a abordagem de coprojeto combinando software e hardware para implementar uma solução de alto desempenho e baixo consumo de energia em um FPGA, capaz de decodificar até 6 canais de áudio em tempo real. Apresentamos os detalhes da solução bem como os testes de desempenho e qualidade. Por fim, apresentamos os resultados de utilização de hardware e performance juntamente com uma comparação com as demais soluções encontradas na literatura. _______________________________________________________________________________________ ABSTRACT
Audio Coding is present today in many electronic devices. It can be found in radio, tv, computers, portable audio players and mobile phones. In 2007 the Brazilian Government defined the brazilian Digital TV System standard (SBTVD) and adopted the AAC - Advanced Audio Coding as the audio codec. In this work we use the co-design of hardware and software approach to implement a high performance and low energy solution on an FPGA, able to decode up to 6 channels of audio in real-time. The solution architecture and details are presented along with performance and quality tests. Finally, hardware usage and performance results are presented and compared to other solutions found in literature.
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Renner, Adriano. "Arquitetura de um decodificador de áudio para o Sistema Brasileiro de Televisão Digital e sua implementação em FPGA." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/49363.

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O Sistema Brasileiro de Televisão Digital estabeleceu como padrão de codificação de áudio o algoritmo MPEG-4 Advanced Audio Coding, mais precisamente nos perfis Low Complexity, High Efficiency versão 1 e High Efficiency versão 2. O trabalho apresenta um estudo detalhado sobre o padrão, contendo desde alguns conceitos da psicoacústica como o mascaramento até a metodologia de decodificação do stream codificado, sempre voltado para o mercado do SBTVD. É proposta uma arquitetura em hardware para um decodificador compatível com o padrão MPEG-4 AAC LC. O decodificador é separado em dois grandes blocos mantendo em um deles o banco de filtros, considerado a parte mais custosa em termos de processamento. No bloco restante é realizada a decodificação do espectro, onde ocorre a decodificação dos códigos de Huffman, o segundo ponto crítico do algoritmo em termos de demandas computacionais. Por fim é descrita a implementação da arquitetura proposta em VHDL para prototipação em um FPGA da família Cyclone II da Altera.
MPEG-4 Advanced Audio Coding is the chosen algorithm for the Brazilian Digital Television System (SBTVD), supporting the Low Complexity, High Efficiency version 1 and High Efficiency version 2 profiles. A detailed study of the algorithm is presented, ranging from psychoacoustics concepts like masking to a review of the AAC bitstream decoding process, always keeping in mind the SBTVD. A digital hardware architecture is proposed, in which the algorithm is split in two separate blocks, one of them containing the Filter Bank, considered the most demanding task. The other block is responsible for decoding the coded spectrum, which contains the second most demanding task of the system: the Huffman decoding. In the final part of this work the conversion of the proposed architecture into VHDL modules meant to be prototyped with an Altera Cyclone II FPGA is described.
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Brewster, Stephanie Joyce. "Asymmetries of power and competence and implications for AAC : interaction between adults with severe learning disabilities and their care staff." Thesis, University of Birmingham, 2007. http://etheses.bham.ac.uk//id/eprint/63/.

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This study investigates the interaction between adults with learning disabilities and their care staff. Many people with severe learning disabilities have little or no speech; for these individuals, augmentative and alternative communication (AAC) may enhance their communication. However, AAC non-use is a widely reported phenomenon. The study explores power and communicative competence within such interaction, as possible factors in AAC non-use. An ethnographic approach was adopted; data collection was carried out in five community homes, focusing on four residents. Field notes were accompanied by video and audio recordings of natural interaction between participants. Aspects of Critical Discourse Analysis were applied to the data within the themes of turn taking, topic control, exclusion from conversation, activity exchanges, test questions and politeness; the theme of AAC was also critically scrutinized. Findings regarding interaction between residents and staff were set in the context of the institution and of wider society. Substantial asymmetries in both communicative competence and power were evident. Staff tended to constrain interaction such that immediate participation of residents was facilitated; however, in the longer term, AAC use is likely to be thereby inhibited. Further application of critical approaches to AAC research is warranted.
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Firrman, Jenni Ann. "ENHANCEMENT OF hFVIII ACTIVITY THROUGH LC MODIFICATIONS FOR GENE THERAPY OF HEMOPHILIA A." Diss., Temple University Libraries, 2015. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/335863.

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Microbiology and Immunology
Ph.D.
Gene therapy for Hemophilia A (HA) using the recombinant Adeno-associated virus (rAAV) offers an alternative to classic treatment, which consists of FVIII protein infusions. However, due to limitations associated with rAAV and the FVIII protein itself, the end result is a transgene expression below therapeutic limits. One approach to improving the therapeutic value of rAAV gene therapy for HA is to engineer a more active FVIII protein through genetic modifications. Preliminary testing revealed that canine FVIII Light Chain (kLC) enhances coagulation activity, and that it would be possible to improve FVIII activity through modifications of the light chain. Through the process of engineering, evaluation, and negative selection of kLC, a final construct was engineered. The hLC-K12 is a human Light Chain (hLC) construct containing 12 amino acid changes that work together to enhance coagulation activity. A comparison of the FVIII clotting activity to the amount of protein produced determined that hLC-K12 produced a 3.28 fold increase in specific activity over hLC in vitro. Similar in vitro results were observed when hLC-k12 was tested with the X5 heavy chain (X5HC), a heavy chain that has been genetically modified to enhance production. CD4KO/HA mice were injected with a rAAV vector carrying the hLC-K12 gene in conjugation with a rAAV vector carrying the X5HC gene. Replacing the hLC vector with the hLC-K12 vector produced an average 7.43 fold increase in FVIII clotting activity. An ELISA assay revealed no significant difference between productions of the heavy or light chains at any time point. By comparing the clotting activity to the amount of protein produced, it was determined that the increase in coagulation activity was due to an increase in specific activity. In fact, replacing the hLC vector with the hLC-K12 vector resulted in an average 5.8 fold increase in FVIII specific activity. The K12 modifications were evaluated using a single chain FVIII conformation. In vitro, the addition of the K12 mutations to the human heavy chain, hHCK12BDD, resulted in a 4.3 fold increase in clotting activity, but no increase in protein production. There was however, a 3.3 fold increase in specific activity of the protein. Adding the K12 mutations to the X5 heavy chain, X5K12BDD, in vitro, resulted in a 2.7 fold increase in clotting activity and a 1.42 fold increase in specific activity of the protein. Single chain rAAV vectors were packaged and delivered to CD4KO/HA mice. Compared to mice injected with hFVIIIBDD, the hHCK12BDD produced an average 4.6 fold increase in clotting activity. An ELISA revealed no significant difference in production between these two groups. However, mice injected with hHCK12BDD produced FVIII with an average of 4.13 fold increase in specific activity. Similarly, when compared to mice injected with X5FVIIIBDD, the X5K12BDD produced an average 2.14 fold increase in clotting activity. An ELISA assay demonstrated no significant increase in protein production between these two groups. However, when compared to X5BDD, mice injected with the X5K12BDD vector produced FVIII with an average 1.98 fold increase in specific activity. Results demonstrate that the K12 light chain modifications are able to enhance clotting activity of hFVIII both in vitro and in vivo, using either a dual chain or single chain delivery method. In order to determine the mechanism of enhancement, hFVIIIBDD and hHCK12BDD protein was partially purified and tested for activity. Results demonstrated that the hHCK12BDD protein produced a specific activity of 39,153.69 Units/mg, which is a 6.28 fold increase over hFVIIIBDD specific activity, which was 6,237.92 Units/mg. Measurement of conversion from FX to FXa revealed that the hHCK12BDD protein generated a higher amount of FXa at a quicker rate. In conclusion, these results provide evidence that the K12 modifications enhance specific activity through an increase in FXa generation.
Temple University--Theses
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Luchessi, André Ducati. "Análise farmacogenômica de pacientes submetidos à dupla antiagregação plaquetária." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-29092011-143838/.

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O presente estudo avaliou o perfil farmacogenômico de 338 pacientes, sob terapia antiagregante. Os pacientes foram submetidos a tratamento prévio com AAS (100mg/dia) e clopidogrel (75mg/dia) por no mínimo cinco dias antes da angioplastia coronária. Os indivíduos com resposta considerada indesejada <30% de inibição de PRU (do inglês, P2RY12 Reaction Unit) para clopidogrel e >550 ARU (do inglês, Aspirin Reaction Unit), foram considerados como não respondedores. As concentrações plasmáticas dos antiagregantes foram determinadas por cromatografia líquida acoplada à espectrometria de massa do tipo triploquadrupolo (LC-MS/MS). A taxa da inibição da agregação plaquetária foi medida utilizando-se o sistema VerifyNow®. A expressão gênica global das células totais do sangue periférico foi avaliada pela tecnologia de microarranjos de DNA Human Exon ST 1.0 Array. Características genotípicas dos pacientes também foram avaliadas pelo sistema Sequenom®. Assim, foi possível obter como resultados a identificação de 64% e 10% para pacientes não respondedores ao clopidogrel e AAS respectivamente, sendo que para o primeiro foi possível identificar a associação desta não resposta a variáveis clínicas como diabetes (p = 0,003), hipertensão (p = 0,011) e hábito de fumar (p = 0,041) e sexo (p = 0,022) e idade dos pacientes (p = 0,004) em relação à resposta ao AAS. O método de quantificação simultânea do clopidogrel, seu metabólito majoritário e do AS (metabólito do AAS), apresentou limites de quantificação entre de 2 a 500 ng/mL, 2 a 2000 ng/mL e de 20 a 2000 ng/mL, respectivamente. O estudo de associação encontrou uma relação significante da presença dos SNPs presentes nos genes CYP5A1 (rs2299890) e CYP2C19 (rs4244285 e rs3758580), com a variação na resposta ao clopidogrel, obtendo um valor de p corrigido pelo teste de permutação inferior a 0,001. Como também, uma fraca associação da variação na resposta do AAS com o SNP rs9605030 do gene COMT (p = 0,009). Os resultados do microarranjos relacionaram a resposta terapêutica ao clopidogrel com os genes CA2, MKRN1, ABCC3 e MBP seguido dos genes NFIA e IGF1R para a resposta ao AAS. Concluindo que o estudo farmacogenômico apresentou todo o seu potencial para relacionar variáveis como resposta, concentração farmacológica plasmática, SNPs e expressão global de RNAm, possibilitando assim compreender melhor a variação no tratamento antiagregante.
This study investigated the pharmacogenomics profile of 338 patients under antiplatelet therapy. Patients undergoing pretreatment with ASA (100 mg/day) and clopidogrel (75mg/day) for at least five days prior to coronary angioplasty. Individuals with response <30% of PRU (P2RY12 reaction unit) were considering non responder for clopidogrel and >550 of ARU (aspirin reaction unit), were considered as non responders for ASA. Plasma concentrations of the antiagregation drugs were determined by liquid chromatography followed mass spectrometry of triple quadrupole detection (LC-MS/MS). The rate of inhibition of platelet aggregation was measured using the VerifyNow® system. The global gene expression of total cells in blood was assessed by DNA microarray technology Human Exon 1.0 ST Array. Genotypic characteristics of the patients were also evaluated by the Sequenom® system. Thus it was possible to obtain results such as identification of 64% and 10% for patients non responders to clopidogrel and aspirin respectively, and for the first could identify the association of this response to variables such as diabetes (p = 0.003), hypertension (p = 0.011) and smoking (p = 0.041) for clopidogrel and sex and age in relation to response to ASA (p = 0.022 and p = 0.004, respectively). The method of simultaneous quantification of clopidogrel and its major metabolite of AS (metabolite of ASA), had quantification limits between 200 to 500 ng/mL 2000-2000 ng/mL and 20 to 2000 ng/mL, respectively. The association study found a significant grating presence of SNPs present in genes CYP5A1 (rs2299890) and CYP2C19 (rs4244285 and rs3758580), with the variation in the response to clopidogrel, obtaining a corrected p value by permutation test below 0.001. As well, a weak association of variation in the response of ASA with the SNP rs9605030 of the gene COMT (p = 0.009). The results of microarray related therapeutic response to clopidogrel with genes CA2, MKRN1, ABCC3 and MBP followed by NFIA and IGF1R genes for response to ASA. Concluding that the pharmacogenomics study showed its potential to relate variables such as response, plasma drug concentration, SNPs and global expression of mRNA, thus enabling better understand the variation in antiplatelet treatment.
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Jamin, Emilien. "Développement de méthodes de spectrométrie de masse pour la caractérisation des Amines Aromatiques Hétérocycliques (AAH) générées lors de la cuisson des aliments et l'étude de leur réactivité vis-à-vis des bases de l'ADN." Phd thesis, Toulouse, INPT, 2007. http://oatao.univ-toulouse.fr/7629/1/jamin.pdf.

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Les AAH sont des substances génotoxiques formées dans la plupart des viandes cuites et pouvant se fixer aux bases de l'ADN. Le premier axe de recherche de cette thèse a concerné le développement d'un protocole simple et rapide de quantification des AAH par l'utilisation d'un spectromètre de masse prototype Py-MAB-ToF, qui a permis la détection directe des AAH dans des extraits de poulet cuit, diminuant ainsi le temps d'analyse. Ces résultats ont été validés à l'aide d'un protocole de dosage par LC-APCI- S/MS d'extraits purifiés utilisé comme méthode de référence. Le deuxième volet de ces travaux a concerné l'étude de la formation des adduits covalents AAH-ADN par spectrométrie de masse. Dans un premier temps, l'étude des adduits AAH-nucléosides a permis de caractériser deux nouveaux adduits. Dans un deuxième temps, la formation des adduits avec des oligonucléotides modèles a été étudiée afin de caractériser l'influence des bases voisines de la modification sur la formation des adduits.
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Kristina, Tešanović. "Биолошка активност и хемијски састав аутохтоних врста гљива Coprinus comatus (O.F. Müll.) Pers. Gray, 1797 и Coprinellus truncorum (Scop.) Redhead, Vilgalys & Monclavo, 2001". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104928&source=NDLTD&language=en.

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У оквиру ове докторске дисертације испитана је биолошка активност екстраката плодних тела и потопљених култура (мицелије и филтрата) аутохтоних врста гљива Coprinus comatus и Coprinellus truncorum. Такође, испитан је  метаболизам фосфата мицелија обе врсте употребом нуклеарно магнетне резонантне спректроскопије (31Р NMR), утицај ванадијума на метаболизам фосфата као и идентификација облика ванадата присутних у ћелији мицелије (51V NMR). Утврђена је антирадикалска и антиоксидативна активност  етанолних,метанолних и водених екстраката гљива при чему су се екстракти потопљених култура издвојили по антирадикалској, а екстракти плодних тела по антиоксидативној активности. Екстракти потопљених култура истакли су се и у погледу антибактеријске активности, где се као најпотентнији показао  хлороформски екстракт филтрата потопљене културе C. comatus. Такође, етанолни екстракт филтрата потопљене културе C. comatus показао се као најпотентнији у анти-ацетилхолинестеразној активности у односу на  конвенционални лек донепезил. Испитан је и утицај екстраката на вијабилност ћелијских линија HepG2 (хумане хепатома ћелије) и Rin-5F (ß ћелије панкреаса пацова).Спектрофотометријским методама одређен је укупан садржај фенола и флавоноида у већини анализираних екстраката.LC/MS идентификацијом и квантификацијом фенолних киселина уочена је разлика између фенолних једињења присутних у плодном телу, мицелији и филтрату потопљене културе. Екстракти потопљених култура бележе већи број и већи садржај једињења. Укупан садржај протеина одређен само у воденим екстрактима, а укупан садржај угљених хидрата у полисахаридним екстрактима.Употребом Фуријеве инфрацрвене спектроскопске методе (FTIR) детектоване су везе између угљених хидрата  присутних у полисахаридним екстрактима, а планарном  хроматографијом показано је да екстракти плодног тела и филтрата врсте С. truncorum, као и екстракт плодног тела врсте C. comatus, садрже велику  количину D-глукозе, док екстракт мицелије C. truncorum, баш као и екстракти филтрата и мицелије C. comatus, садрже највише галактозе. Квалитативном и квантитативном елементарном анализом (ААS) утврђен је виши садржај  калијума и гвожђа у анализираним узорцима. GC-МS идентификацијом и квантификацијом масних киселина указано је на значајно присуство линолне киселине код обе врсте. Како за аутохтону врсту  C.truncorum постоји мало података у литератури, подаци о њеном хемијском саставу могу се сматрати иновативним.Компаративним прегледом биолошке активности и хемијског састава екстраката плодног тела и мицелије и филтрата (потопљених култура) указано је да су анализирани екстракти извори биоактивних супстанци са медицинским потенцијалом, а потопљене културе датих гљива представљају атрактивне кандидате за даља биотехнолошка истраживања.
U okviru ove doktorske disertacije ispitana je biološka aktivnost ekstrakata plodnih tela i potopljenih kultura (micelije i filtrata) autohtonih vrsta gljiva Coprinus comatus i Coprinellus truncorum. Takođe, ispitan je  metabolizam fosfata micelija obe vrste upotrebom nuklearno magnetne rezonantne sprektroskopije (31R NMR), uticaj vanadijuma na metabolizam fosfata kao i identifikacija oblika vanadata prisutnih u ćeliji micelije (51V NMR). Utvrđena je antiradikalska i antioksidativna aktivnost  etanolnih,metanolnih i vodenih ekstrakata gljiva pri čemu su se ekstrakti potopljenih kultura izdvojili po antiradikalskoj, a ekstrakti plodnih tela po antioksidativnoj aktivnosti. Ekstrakti potopljenih kultura istakli su se i u pogledu antibakterijske aktivnosti, gde se kao najpotentniji pokazao  hloroformski ekstrakt filtrata potopljene kulture C. comatus. Takođe, etanolni ekstrakt filtrata potopljene kulture C. comatus pokazao se kao najpotentniji u anti-acetilholinesteraznoj aktivnosti u odnosu na  konvencionalni lek donepezil. Ispitan je i uticaj ekstrakata na vijabilnost ćelijskih linija HepG2 (humane hepatoma ćelije) i Rin-5F (ß ćelije pankreasa pacova).Spektrofotometrijskim metodama određen je ukupan sadržaj fenola i flavonoida u većini analiziranih ekstrakata.LC/MS identifikacijom i kvantifikacijom fenolnih kiselina uočena je razlika između fenolnih jedinjenja prisutnih u plodnom telu, miceliji i filtratu potopljene kulture. Ekstrakti potopljenih kultura beleže veći broj i veći sadržaj jedinjenja. Ukupan sadržaj proteina određen samo u vodenim ekstraktima, a ukupan sadržaj ugljenih hidrata u polisaharidnim ekstraktima.Upotrebom Furijeve infracrvene spektroskopske metode (FTIR) detektovane su veze između ugljenih hidrata  prisutnih u polisaharidnim ekstraktima, a planarnom  hromatografijom pokazano je da ekstrakti plodnog tela i filtrata vrste S. truncorum, kao i ekstrakt plodnog tela vrste C. comatus, sadrže veliku  količinu D-glukoze, dok ekstrakt micelije C. truncorum, baš kao i ekstrakti filtrata i micelije C. comatus, sadrže najviše galaktoze. Kvalitativnom i kvantitativnom elementarnom analizom (AAS) utvrđen je viši sadržaj  kalijuma i gvožđa u analiziranim uzorcima. GC-MS identifikacijom i kvantifikacijom masnih kiselina ukazano je na značajno prisustvo linolne kiseline kod obe vrste. Kako za autohtonu vrstu  C.truncorum postoji malo podataka u literaturi, podaci o njenom hemijskom sastavu mogu se smatrati inovativnim.Komparativnim pregledom biološke aktivnosti i hemijskog sastava ekstrakata plodnog tela i micelije i filtrata (potopljenih kultura) ukazano je da su analizirani ekstrakti izvori bioaktivnih supstanci sa medicinskim potencijalom, a potopljene kulture datih gljiva predstavljaju atraktivne kandidate za dalja biotehnološka istraživanja.
The biological activity of extracts of basidiocarps (fruiting bodies)  and submerged cultures (mycelium and filtrate) of autochthonous mushroom species  Coprinus comatus and  Coprinellus truncorum  was examined. Furthermore, the metabolism of phosphate  of mycelia  of both types was studied using nuclear magnetic  resonance spectros-copy ( 31 R NMR), the influence of vanadium on phosphate metabolism and the identification of vanadate oxidation states present in the mycelia cell ( 51 V NMR). The antiradical and antioxidant activity of methanolic, ethanolic and water fungal extracts was determined. Extracts of submerged cultures achieved the best anti- radical activity while fruit body extracts showed the best antioxidant activity. Extracts of submerged cultures also highlighted in terms of antibacterial activity, where the chloroform extract of the submerged culture  C. comatus  showed as the most potent. Also, the ethanolic extract of the submerged culture of  C. comatus  was found to be most relevant in anti-acetylcholinesterase activity  compared with  the conventional donepezil drug. The influence of extracts on the viability of cell lines HepG2 (human hepatocytes cells) and Rin-5F (ß pancreatic cells of the rat) was also examined.Spectrophotometric methods determined the total con-tent of phenol and flavonoids in most of the analyzed extracts.The LC/MS identification and quantification of phenolic acids revealed the difference between the phenolic compounds present in the fruiting body, mycelium, and the submerged culture filtrate. Extracts of submerged cultures record a greater number and higher content of compounds.The total content of proteins determined only in water extracts  and the total content of  carbohydrates in poly-saccharide extracts. Using the Fourier infrared spectro-scopic method (FTIR), the links between the sugar pre-sent in the  polysaccharide extracts were detected, and planar chromatography showed that the extracts  of the fruiting body and the filtrate of type  C. truncorum, as well as the extract of the fruiting body of the species  C. comatus, contain a large amount of D-glucose, while the extract of the  C. truncorum  mycelia  and  mycelia  of  C. comatus, contain the most galactose. GC-MS identification and quantification of fatty acids indicated a significant presence of linoleic acid in both species, while qualitative and quantitative elemental analysis (AAS) has determined a higher content of potas-sium and iron in the analyzed samples. Since there is no data in the literature for the autochtho-nous species  C. truncorum, the studies on its chemical composition can be considered advanced аs innovative. A comparative review of the biological activity and the chemical composition of the extracts of the fruiting body and  mycelia  and filtrates  of  medium of  submerged cultures  indicated that the extracts were analyzed by sources of bioactive substances with medical potential, and the submerged cultures of these mushrooms are attractive candidates for biotechnological research.
В рамках данной работы была исследованна биологическая активность экстракта плодородных тел и погружонных видов култур (мицелии и филтрата) автотоных видов грибов Coprinus comatus и Coprinellus truncorum. Также, исследованн метаболизм фосфата обеих видов  мицелий с помощью ядерного магнитного резонанса спектроскопии (31Р ЯМР), влияние на содержание ванадия в метаболизме фосфата, а также идентификация формы ванадата присущего в клеток мицеллий (51V ЯМР). Установленная антирадикальная и антиоксидантная активность метанольных, этанольных и водных экстрактов гриб, причём выделяются экстракты погружённых культур по антирадикальной активности и  экстракты плодородных тел по антиоксидантной активности.Экстракты погружённых культур выделялись и в плане антибактериальной активности, причем,  наиболее мощным из филтратов показался экстракт хлороформа погруженной культуры C. comatus. А также этанольный экстракт филтрата погружённой культуры C. comatus оказался найболее мощным в анти-ацетихолинестеразной активностипо сравнению с традиционным лекарством донепезилом. Было исследовано и влияние экстрактов на виябильность клеток линий   HepG2 (гуманые хепатома клетки) и Rin-5F (ß клетки поджелудочной железы крыс).Методом спектрофотометрии определена совокупность фенола и флавоноида в большинстве проанализированных экстрактах.С помощью ЛС ̸МС идентификации и квантификации фенолных кислот была замечена разница между соединениями фенола, присущих в плодородном теле, и мицелии, и филтрата погружённой культуры. Экстракты погружённых культур отражают больше количество и более высокое содержание соединений.Общее содержание белков выделен только в водяных экстрактах, и общее содержание углеводов в полисахаридных экстрактах. Используя инфракрасный метод спектроскопии Фурия (ИКМСФ) были обнаружены связи между сахарами, присущими в полисахаридных экстрактах, а планарной хромотографиой было показано, что экстракты плодородного тела и филтратов вида С. truncorum,  а  также и экстракты плодородного тела вида C. comatus содержат большое количество D-глюкозы, в то время как экстракт мицелии C. truncorum, именно как и экстракт фильтрата и мицелии C. comatus, содержат больше всего галактозы.GC-МS идентификацией и квантификацией жирных кислот показано значительное наличие линолевой кислоты у обоих видах. А качественным и квантитативным элементарным анализом установленно большее содержание калиума и железа в анализированых шаблонах.Из-за того, что для автохтонного вида C. truncorum практически не было данных в литературе, данные о её химическом составе можно считать прогрессивным и инновационным.Сравнительный анализ биологической активности и химического состава экстрактов плодородного тела и мицелии и фильтрат (погружённых культур) показаывает, что проанализированные экстракты — источники биологически активных веществ с медицинским потенциалом, и погружённые культуры данных гриб являются привлекательными кандидатами для биотехнологических исследований.
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8

Milena, Rašeta. "Детекција биоактивних супстанци одабраних врста гљива рода Ganoderma (Basidiomycota) и њихова биолошка активност". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2016. https://www.cris.uns.ac.rs/record.jsf?recordId=101530&source=NDLTD&language=en.

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 У оквиру ове докторске дисертације испитан је хемијски састав и биолошке активности ЕtOH, H2Oи CHCl3  екстраката четири врсте гљива рода Ganoderma  (Basidiomycota):  G. applanatum,  G. lucidum,G. pfeifferi,  G. resinaceum  са територије Војводине.Хемијски састав анализираних врста је одређенприменом: ААЅ методе (састав макро-  имикроелемената у сувим остацима гљива) и LC-MS/MS технике (квантитативни састав фенолних једињења и флавоноида) при чему је детектовано 12 једињења. Спектрофотометријским методама је одређен садржај протеина, шећера, укупних фенола и флавоноида, код којих је највећи садржај протеина утврђен за ЕtOH екстракте  G. applanatum  и  G. pfeifferi. Испитивања биолошких активности екстраката обухватила су: одређивање   in vitro   и  in vivo антиоксидантне, антимикробне, антиинфламаторне, антипролиферативне и антијабето гене   aктивности.      Антиоксидантна активност (способност неутрализације слободних радикала и редукциони потенцијал) је одређена спектрофотометријским методама, при којој су најбољу активност остварили Н2О екстракти  G. applanatum. Антимикробнa активност  анализираних екстраката одређена је испитивањем антибактеријског, антифунгалног и антивиралног потенцијала где се издвојила G. pfeifferi врста. Антиинфламаторни потенцијал EtOH и  CHCl3 екстраката одређен је  ex vivo  методом мерењем способности инхибиције продукције медијатора инфламације  (продукти  метаболизма арахидонске киселине) при којој су бољу активност испољили CHCl3 екстракти.Ефекат EtOH и H2O екстраката врста рода Ganoderma   на раст MCF ћелијске линије испитан је MTT тестом, а посебно су се издвојили  EtOH  екстракти врста после 72h.Остварена антидијабетогена активност EtOH и Н2О екстраката врста   G. pfeifferi   и  G. resinaceum  код алоксан-индукованог  D. mell itus-a  на  експерименталним  животињама  праћена je регенерацијом  ß- ћелија  Лангерхансових острваца панкреаса. Као потенцијални нефро-  и  хепатопротективни агенси се издвајају екстракти  G. resinaceum.Сумарно, укупни биопотенцијал анализираних врста рода  Ganoderma  на основу спроведених анализа хемијске   kарактеризације и биолошке активности упућује  на  могућност њихове потенцијалне примене као нутрацеутика и додатака исхрани, у будућности уз неопходност додатних микохемијских истраживања ових врста, посебно терпеноида и полисахарида, као и других биолошких активности као што је неуропротективна.
 U okviru ove doktorske disertacije ispitan je hemijski sastav i biološke aktivnosti EtOH, H2Oi CHCl3  ekstrakata četiri vrste gljiva roda Ganoderma  (Basidiomycota):  G. applanatum,  G. lucidum,G. pfeifferi,  G. resinaceum  sa teritorije Vojvodine.Hemijski sastav analiziranih vrsta je određenprimenom: AAЅ metode (sastav makro-  imikroelemenata u suvim ostacima gljiva) i LC-MS/MS tehnike (kvantitativni sastav fenolnih jedinjenja i flavonoida) pri čemu je detektovano 12 jedinjenja. Spektrofotometrijskim metodama je određen sadržaj proteina, šećera, ukupnih fenola i flavonoida, kod kojih je najveći sadržaj proteina utvrđen za EtOH ekstrakte  G. applanatum  i  G. pfeifferi. Ispitivanja bioloških aktivnosti ekstrakata obuhvatila su: određivanje   in vitro   i  in vivo antioksidantne, antimikrobne, antiinflamatorne, antiproliferativne i antijabeto gene   aktivnosti.      Antioksidantna aktivnost (sposobnost neutralizacije slobodnih radikala i redukcioni potencijal) je određena spektrofotometrijskim metodama, pri kojoj su najbolju aktivnost ostvarili N2O ekstrakti  G. applanatum. Antimikrobna aktivnost  analiziranih ekstrakata određena je ispitivanjem antibakterijskog, antifungalnog i antiviralnog potencijala gde se izdvojila G. pfeifferi vrsta. Antiinflamatorni potencijal EtOH i  CHCl3 ekstrakata određen je  ex vivo  metodom merenjem sposobnosti inhibicije produkcije medijatora inflamacije  (produkti  metabolizma arahidonske kiseline) pri kojoj su bolju aktivnost ispoljili CHCl3 ekstrakti.Efekat EtOH i H2O ekstrakata vrsta roda Ganoderma   na rast MCF ćelijske linije ispitan je MTT testom, a posebno su se izdvojili  EtOH  ekstrakti vrsta posle 72h.Ostvarena antidijabetogena aktivnost EtOH i N2O ekstrakata vrsta   G. pfeifferi   i  G. resinaceum  kod aloksan-indukovanog  D. mell itus-a  na  eksperimentalnim  životinjama  praćena je regeneracijom  ß- ćelija  Langerhansovih ostrvaca pankreasa. Kao potencijalni nefro-  i  hepatoprotektivni agensi se izdvajaju ekstrakti  G. resinaceum.Sumarno, ukupni biopotencijal analiziranih vrsta roda  Ganoderma  na osnovu sprovedenih analiza hemijske   karakterizacije i biološke aktivnosti upućuje  na  mogućnost njihove potencijalne primene kao nutraceutika i dodataka ishrani, u budućnosti uz neophodnost dodatnih mikohemijskih istraživanja ovih vrsta, posebno terpenoida i polisaharida, kao i drugih bioloških aktivnosti kao što je neuroprotektivna.
Whitin this doctoral thesis the chemical composition and biological activity of EtOH, H 2 O and CHCl3 extracts of four fungal species which belong to genus Ganoderma  (phylum Basidiomycota) :  G. applanatum,  G. lucidum,  G. pfeifferi,  G. resinaceum  were determinated. The samples were collected from different localities in Vojvodina. Chemical characterization included: AAS methods (compositon of macro- and  microelements in d.w. of fungi) and LC-MS/MS technique (quantitative analysis of phenolic compounds and flavonoids) wherein the 12 selected phenolic compounds were detected. The total proteins, sugars, phenolics and flavonoids content were    determined using spectrophotometric methods. The highest protein content was determined in EtOH extracts of  G. applanatum   and G. pfeifferi  species. In order to assess the biological potential, the in vitro  and in vivo antioxidant, antimicrobial, anti-inflammatory, antiproliferative and antidiabetic activities of the extracts were investigated.    The antioxidant activity (the ability of neutralizing free radicals and reduction potential) estimated byspectrophotometric methods. The highest   antioxidant potential was noticed in H2O extracts of  G. applanatum. Evaluation of antimicrobial activity included the estimation of antibacterial, antifungal and antiviral activity, whereby the  species  G. pfeifferi  showed the highest potential The anti-inflammatory activity of EtOH and  CHCl3  extracts was determined by  ex vivo  method measuring the ability of production inhibition of inflammation mediators  (products of arachidonic acid metabolism), where the CHCl3  extracts were exhibited better activity.   The effect of EtOH and H2O extracts of  Ganoderma species on the growth of the cell line MCF-7, has been examined using MTT assay (stand out ethanolic extracts of analyzed species after 72h incubation period).   Achieved antidiabetic activity of EtOH and H2O extracts of  G. pfeifferi   and G. resinaceum  at alloxan-i nduced D. mellitus in experimental animals was followed by regeneration of  cells of Langerhans pancreatic islets. Extracts of  G.   resinaceum  were allocated as a potential nephro- and  hepatoprotective agents.In summary, the overall biological potential of the analyzed species of the genus  Ganoderma  based on results for chemical and biological characterization indicate that they could be used  as a nutraceuticals and food supplements in the future, with further the necessity of additional mycochemical investigation (especially terpenoids and polysaccharides) and other biological activity such as neuroprotective.
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Kroová, Michaela. "Molekulární analýza rezistenčního genu vga(A)LC - identifikace klíčových aminokyselinových zbytků." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-312700.

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Protein Vga(A) gives staphylococci resistance to streptogramins A. The recently discovered protein Vga(A)LC differs from Vga(A) only by 7 amino acid residues, but this difference is sufficient for shift of its substrate specificity towards lincosamides. The group of four amino acids in the central part of protein (LGAG in Vga(A) and SVTS in Vga(A)LC) was detected to be crucial for the substrate specificity. In this diploma thesis 5 alternativesets of vga(A)LC gene point mutations were prepared in order to determine the impact of individual amino acids of the aforementioned group on the resistance phenotype. Mutations were prepared in vector pGEM® -T and cloned into shuttle vector pRB374. The prepared constructs were transformed by electroporation into the sensitive strain of Staphylococcus aureus RN4220 and values of minimum inhibitory concentration (MIC) were measured for lincomycin, clindamycin and pristinamycin IIA by the agar dilution method. The transformation was not successful in one of the mutations. Results of setting MIC for the remaining four mutations do not make it possible to specify uniquely the ratio of individual amino acids for determining substrate specificity. Two of the amino acids were found to be important. We anticipate preparation of more mutations.
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Nguyen, Thi Ngoc Bich. "Buněčná lokalizace rezistentních proteinů Vga(A)LC a Msr(A) prostřednictvím fluorescenční mikroskopie." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388649.

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Vga(A)LC and Msr(A) are clinically significant resistant proteins in staphylococci that confer resistance to translational inhibitors. They belong to ARE ABC-F protein subfamily, which is part of ABC transporters. Unlike typical ABC transporters, ABC-F proteins do not have transmembrane domains that are responsible for the transport of substances through the membrane. Therefore, they do not have characteristic transport function but regulatory or resistance function. Their mechanism of action on the ribosome has been described only recently, where these proteins displace the antibiotic from the ribosome. However, some aspects of their function are still unclear. For example, what is the function of the Vga(A) location on a membrane that has been detected in the membrane fraction but not in the ribosomal. In this work, using fluorescence microscopy, I observed subcellular localization of the Vga(A)LC-mEos2, Vga(A)LC-GFP and Msr(A)-eqFP650 resistant fusion proteins in live cells of S. aureus under different culture conditions . It has been shown that Vga(A)LC-GFP and Msr(A)-eqFP650 occur in a foci near the membrane. Depending on ATPase activity or the presence of an antibiotic, the localization of Msr(A)-eqFP650 in the cell changes from focal to diffuse, presumably on ribosomes, suggesting a...
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Book chapters on the topic "AAC LC"

1

"Introduction to Electric Drives with LC Filters." In Variable Speed AC Drives with Inverter Output Filters. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118782989.ch1.

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"Control of Induction Motor Drives with LC Filters." In Variable Speed AC Drives with Inverter Output Filters. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118782989.ch6.

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"Multiphase Drive with Induction Motor and an LC Filter." In Variable Speed AC Drives with Inverter Output Filters. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118782989.ch9.

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"Estimation of the State Variables in the Drive with LC Filter." In Variable Speed AC Drives with Inverter Output Filters. John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118782989.ch5.

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Conference papers on the topic "AAC LC"

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Chivukula, Ravi K., Yuriy A. Reznik, and Venkat Devarajan. "Efficient algorithms for MPEG-4 AAC-ELD, AAC-LD and AAC-LC filterbanks." In 2008 International Conference on Audio, Language and Image Processing (ICALIP). IEEE, 2008. http://dx.doi.org/10.1109/icalip.2008.4590245.

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Lai, Te-Hsueh, Chung-Neng Wang, and Tihao Chiang. "A NMR Optimized Bitrate Transcoder for MPEG-2/4 LC-AAC." In 2007 IEEE International Symposium on Circuits and Systems. IEEE, 2007. http://dx.doi.org/10.1109/iscas.2007.378661.

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Ito, Masaki, Takashi Todaka, Takanobu Tsunoda, et al. "Heterogeneous Multiprocessor on a Chip Which Enables 54x AAC-LC Stereo Encoding." In 2007 IEEE Symposium on VLSI Circuits. IEEE, 2007. http://dx.doi.org/10.1109/vlsic.2007.4342719.

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Mohebbi, Mohammad, Joseph Latham, Michael L. McIntyre, and Pablo Rivera. "Filter-based control of an H-Bridge inverter with output LC filter." In 2017 American Control Conference (ACC). IEEE, 2017. http://dx.doi.org/10.23919/acc.2017.7963580.

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Jian, Jiang, and Fan Xiangning. "A fully integrated LC VCO with 1V voltage supply for wireless sensor network applications." In 2013 International Conference on Advanced Technologies for Communications (ATC 2013). IEEE, 2013. http://dx.doi.org/10.1109/atc.2013.6698159.

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Srinivasan, Mohan, Lourdes Thevanayagam, Indrani Chakraborty, et al. "Abstract 2446: Biodistribution of antibody drug conjugates by LC-MS." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-2446.

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Mak, Tytus, John B. Tyburski, John F. Kalinich, and Albert J. Fornace. "Abstract 116: A novel methodology for analyzing post-processed LC/MS metabolomics data." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-116.

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Zeng, Xuemei, Brian L. Hood, Ting Zhao, et al. "Abstract 4564: Lung cancer serum biomarker discovery using label free LC-MS/MS." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-4564.

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Zhu, Jiangjiang, Danijel Djukovic, Lingli Deng, et al. "Abstract B52: Targeted LC-MS/MS metabolic profiling for colon cancer progression monitoring." In Abstracts: AACR Special Conference: Metabolism and Cancer; June 7-10, 2015; Bellevue, WA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1557-3125.metca15-b52.

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Walden, Chad A., Joel M. Reid, Renee M. McGovern, Joseh M. Covey, and Matthew M. Ames. "Abstract 4557: LC/MS/MS assay and mouse pharmacokinetics of the phenylurea thiocarbamate NSC 161128." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-4557.

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