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Dissertations / Theses on the topic 'AARS2'

Author: Grafiati

Published: 9 March 2023

Last updated: 31 July 2025

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1

DIODATO, DARIA. "Identification and functional validation of new mtDNA and nuclear gene variants responsible for mitochondrial disorders." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50549.

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My project has been focused on the identification and validation of new mitochondrial gene variants and new mitochondria-related genes. The first report is about a woman presenting with a stroke-like episode and an history of severe hearing loss, frequent migraines, exercise intolerance, myalgias and limb-girdle muscle weakness indicating a slowly progressive myopathy and secondary amenorrhea with low gonadotropin levels. A muscle biopsy showed ragged-red, cytochrome c oxidase-negative fibers, and an isolated defect of cytochrome c oxidase activity in muscle mitochondria and sequence analysi

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2

Hausmann, Corinne D. "Multi-Aminoacyl-Trna Synthetase Complexes In Archaeal Translation." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1213641006.

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3

Guth, Ethan. "tRNA Identity Mediated Control of the Catalytic mechanism in E. coli Histidyl-tRNA Synthetase." ScholarWorks @ UVM, 2008. http://scholarworks.uvm.edu/graddis/98.

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The aminoacyl-tRNA synthetases (aaRSs) are the universal set of enzymes responsible for attaching amino acids to tRNA to be used as substrates in the process of protein translation. As these enzymes act at the transition between nucleic acids and proteins, their specificity of action is critical for maintaining the fidelity of the genetic code. From a mechanistic standpoint, aaRS specificity is enforced by a complex series of tRNA structural and chemical elements that collectively make up its identity set and serve to distinguish one tRNA from another. Based on sequence, structure, and

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4

Sanders, Michael. "THE EFFECT OF IMMEDIATE FEEDBACK AND AFTER ACTION REVIEWS (AARS) ON LEARNING, RETENTION AND TRANSFER." Master's thesis, University of Central Florida, 2005. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3657.

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An After Action Review (AAR) is the Army training system's performance feedback mechanism. The purpose of the AAR is to improve team (unit) and individual performance in order to increase organizational readiness. While a large body of knowledge exists that discusses instructional strategies, feedback and training systems, neither the AAR process nor the AAR systems have been examined in terms of learning effectiveness and efficiency for embedded trainers as part of a holistic training system. In this thesis, different feedback methods for embedded training are evaluated based on the timing an

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5

Schwerdtner, Annegret [Verfasser], and Florian [Akademischer Betreuer] Baumann. "Atlanto-axiale Rotationssubluxation (AARS) im Kindesalter - Diagnostik, Therapie und Langzeitergebnisse aus manualmedizinischer Sicht / Annegret Schwerdtner ; Betreuer: Florian Baumann." Regensburg : Universitätsbibliothek Regensburg, 2020. http://d-nb.info/1204635889/34.

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6

Aarse, Janna Maria [Verfasser], Denise [Gutachter] Manahan-Vaughan, and Stefan [Gutachter] Herlitze. "Investigations of the functional mechanisms underlying communication between the cerebellum and the hippocampus / Janna Maria Aarse ; Gutachter: Denise Manahan-Vaughan, Stefan Herlitze." Bochum : Ruhr-Universität Bochum, 2017. http://d-nb.info/1125106026/34.

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7

Kuzmishin, Nagy Alexandra Burden. "Maintaining Fidelity of Translation by Bacterial Trans-Editing Proteins:Caulobacter crescentus ProXp-ala and Rhodopseudomonas palustris ProXp-x." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1563478757446243.

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8

Holmborn, Towe. "Zooplankton growth and trophic linkages : Implications for fish feeding conditions in the Baltic Sea." Doctoral thesis, Stockholms universitet, Systemekologiska institutionen, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-29485.

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The aim of this Thesis was to improve our understanding and assessment of feeding conditions for zooplanktivorous fish in the Baltic Sea. We investigated (papers I, II) the usefulness of biochemical proxies for assessments of growth and metabolic rates in the dominant Baltic copepod Acartia bifilosa. A predictive model (paper I) for egg production rate (EPR), based on body size, RNA content, and water temperature, was established using females of different geographical origin. This model demonstrates the usefulness of RNA content as a proxy for growth in zooplankton and, together with abundanc

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9

Gonzalez, Serrano Ligia Elena. "Caractérisation de l'ArgRS mitochondriale humaine et contribution à la compréhension des pathologies liées aux mutations des aminoacyl-ARNt synthétases mitochondriales." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ074/document.

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Les aminoacyl-ARNt synthétases mitochondriales humaines (aaRS mt) sont des enzymes clés de la traduction mitochondriale. Elles catalysent l'aminoacylation des ARNt par les acides aminés correspondent. Des mutations dans leurs gènes sont corrélées à des pathologies avec un large spectre de phénotypes cliniques, mais aux mécanismes moléculaires sous-jacents encore incompris. L'objectif de ce travail de thèse s'intègre dans les axes scientifiques du laboratoire, mais élargit l'intérêt et les connaissance à un système encore peu exploré: l'arginyl-ARNt synthétase mitochondriale (ArgRS mt). Des mut

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10

Galatolo, Daniele. "An integrated, next-generation approach to identify new genes and new pathways in hereditary ataxias." Doctoral thesis, 2020. http://hdl.handle.net/2158/1188709.

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The Hereditary ataxias (HAs) are a group of heterogenous neurological disorders associated with multiple genetic etiologies and encompassing a wide spectrum of phenotypes, where ataxia is the prominent feature. HAs are characterized by degeneration of Purkinje cell and/or spinocerebellar connections, often associated with defects in additional brain structures, and all patterns of inheritance may occur. Similar to other fields of medical genetics, Next Generation Sequencing (NGS) has entered the HA scenario widening our genetic and clinical knowledge of this condition, but routine NGS applicat

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11

Chang, Chih-Yao, and 張至堯. "Involvement of Arc1p biotinylation and a WHEP domain on aaRS activity." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/c3dx8m.

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博士<br>國立中央大學<br>生命科學系<br>104<br>Previous studies showed that cytoplasmic methionyl-tRNA synthetase (MetRS) and glutamyl-tRNA synthetase (GluRSc) form a ternary complex with an aaRS cofactor, Arc1p, thereby enhancing their aminoacylation activities. In addition, Arc1p also regulates the subcellular distribution of these two associated enzymes. Upon dissociation from the ternary complex, GluRSc and MetRS are targeted into the mitochondria and nucleus for functioning. The structure of Arc1p can be divided into three domains, N, M, and C domains. The N domain interacts with GluRSc and MetRS, while

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12

Oliveira, João Pedro Ferreira. "Identification of transcription factors involved in Candida albicans mistranslation." Master's thesis, 2018. http://hdl.handle.net/10773/25178.

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Candida albicans is the main human fungal pathogen. It is usually commensal yet when immunocompromised individuals are exposed to it infections normally develop from mild rashes to systemic disease. Candida albicans is characterized by the reassignment of the CUG codon from Leucine to Serine by a hybrid serine tRNA (tRNACAGSer) which decodes the leucine-CUG as leucine (3 to 5 %) and as serine (95 to 97 %) under normal growth conditions. The tRNACAGSer is aminoacylated by two aminoacyl tRNA synthetases, the leucyl-tRNA synthetase (LeuRS) and the seryl-tRNA synthetase (SerRS). Previous studies s

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13

Hirsch, Shawn Lowell. "Utility of the YSR and AARS in discriminating aggressive versus non-aggressive adolescents in an inpatient sample." 2005. http://digital.library.okstate.edu/etd/umi-okstate-1397.pdf.

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14

Cheng, Hsiu-Jung, and 鄭绣蓉. "The intervention model, causal model and application of After Action Reviews(AARs): action research of a business case." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/21022494706734521455.

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碩士<br>東吳大學<br>企業管理學系<br>91<br>For the more and more severe competition in world’s business environment, Corporations pay much attention to their learning abilities. AARs(After Action Reviews) which was mentioned many times in Peter Senge et al’s book “The Dance of Change” has been one of the new growing developments. Though the AARs infrastructure has high potential for facilitating the creation and management of knowledge, it’s lack of strong evidences and basis of practice and theories, in particular the experiences of business who used this tool are rarely seen in bibliographies until now.

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15

Hansia, Priti. "Structure Function Relationship In Tryptophanyl tRNA Synthetase Through MD Simulations & Quantum Chemical Studies On Unusual Bonds In Biomolecules." Thesis, 2009. https://etd.iisc.ac.in/handle/2005/923.

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Biological processes are so complicated that to understand the mechanisms underlying the functioning of biomolecules it is inevitable to study them from various perspectives and with a wide range of tools. Understanding the function at the molecular level obviously requires the knowledge of the three dimensional structure of the biomolecules. Experimentally this can be obtained by techniques such as X‐ray crystallography and NMR studies. Computational biology has also played an important role in elucidating the structure function relationship in biomolecules. Computationally one can obtain the

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16

Hansia, Priti. "Structure Function Relationship In Tryptophanyl tRNA Synthetase Through MD Simulations & Quantum Chemical Studies On Unusual Bonds In Biomolecules." Thesis, 2009. http://hdl.handle.net/2005/923.

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Biological processes are so complicated that to understand the mechanisms underlying the functioning of biomolecules it is inevitable to study them from various perspectives and with a wide range of tools. Understanding the function at the molecular level obviously requires the knowledge of the three dimensional structure of the biomolecules. Experimentally this can be obtained by techniques such as X‐ray crystallography and NMR studies. Computational biology has also played an important role in elucidating the structure function relationship in biomolecules. Computationally one can obtain the

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17

Ghosh, Amit. "Structure-Function Correlations In Aminoacyl tRNA Synthetases Through The Dynamics Of Structure Network." Thesis, 2008. https://etd.iisc.ac.in/handle/2005/822.

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Aminoacyl-tRNA synthetases (aaRSs) are at the center of the question of the origin of life and are essential proteins found in all living organisms. AARSs arose early in evolution to interpret genetic code and are believed to be a group of ancient proteins. They constitute a family of enzymes integrating the two levels of cellular organization: nucleic acids and proteins. These enzymes ensure the fidelity of transfer of genetic information from the DNA to the protein. They are responsible for attaching amino acid residues to their cognate tRNA molecules by virtue of matching the nucleotide tri

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18

Ghosh, Amit. "Structure-Function Correlations In Aminoacyl tRNA Synthetases Through The Dynamics Of Structure Network." Thesis, 2008. http://hdl.handle.net/2005/822.

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Aminoacyl-tRNA synthetases (aaRSs) are at the center of the question of the origin of life and are essential proteins found in all living organisms. AARSs arose early in evolution to interpret genetic code and are believed to be a group of ancient proteins. They constitute a family of enzymes integrating the two levels of cellular organization: nucleic acids and proteins. These enzymes ensure the fidelity of transfer of genetic information from the DNA to the protein. They are responsible for attaching amino acid residues to their cognate tRNA molecules by virtue of matching the nucleotide tri

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19

Odoi, Keturah. "Orthogonality and Codon Preference of the Pyrrolysyl-tRNA Synthetase-tRNAPyl pair in Escherichia coli for the Genetic Code Expansion." Thesis, 2012. http://hdl.handle.net/1969.1/ETD-TAMU-2012-05-11037.

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Systematic studies of basal nonsense suppression, orthogonality of tRNAPyl variants, and cross recognition between codons and tRNA anticodons are reported. E. coli displays detectable basal amber and opal suppression but shows a negligible ochre suppression. Although detectable, basal amber suppression is fully inhibited when a pyrrolysyl-tRNA synthetase (PylRS)-tRNAPyl_CUA pair is genetically encoded. trnaPyl_CUA is aminoacylated by an E. coli aminoacyl-tRNA synthetase at a low level, however, this misaminoacylation is fully inhibited when both PylRS and its substrate are present. Besides th

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